An
adaptive radiotherapy system (100) with biophysical real-time monitoring of the tissue response, wherein the
system (100) comprises: a module (1) for real-time biophysical tissue response monitoring, configured to acquire live data on the physiological response and tissue response from a treatment area of a patient during
irradiation; a module (2) for localizing patient
anatomy and
motion detection, configured to detect position changes, organ movements and target shifts in real time; an engine (3) for adaptive treatment planning and
dose recalculation, configured to dynamically update a
radiotherapy treatment plan based on data received from the module (1) for real-time biophysical monitoring of tissue response and from the module (2) for localizing patient
anatomy and
motion detection; an engine for predictive modeling of tissue response (4) configured to estimate short-term tissue response,
tumor response and
normal tissue tolerance using
patient data from current and previous sessions; an interface for controlling and modulating the beam (5) which is functionally coupled to a
radiation delivery device and configured to modify one or more beam parameters in real time; a safety check and treatment lock control (6) configured to compare current treatment conditions with one or more allowable thresholds and selectively interrupt, stop, or release
radiation delivery; and a module (7) for clinical review, data
logging and
treatment evaluation, configured to store
treatment response data, generate session-related adjustment protocols and provide one or more recommendations for subsequent fractions, wherein the
system (100) adaptively modifies the
radiation output in response to continuously monitored biophysical tissue conditions of the patient.