The present invention provides methods of preventing, treating, managing or ameliorating
periodontal disease, Gorham-Stout
disease, Wilson's
disease,
chronic otitis media, hypertrophic pulmonary osteoarthropathy or
aseptic loosening of
joint replacement (prostheses), or conditions associated therewith, utilizing antagonists of
integrin alphavbeta3. The present invention encompasses the use of methods of preventing, treating, managing or ameliorating
periodontal disease, Gorham-Stout
disease, Wilson's disease,
chronic otitis media, hypertrophic pulmonary osteoarthropathy, or
aseptic loosening of
joint replacement (prostheses), or conditions associated therewith, utilizing an
integrin alphavbeta3
antagonist in combination with another therapy (e.g., another prophylactic or therapeutic agent). In particular, the present invention provides methods of preventing, treating, managing or ameliorating
periodontal disease, Gorham-Stout disease, Wilson's disease,
chronic otitis media, hypertrophic pulmonary osteoarthropathy or
aseptic loosening of
joint replacement (prostheses), or conditions associated therewith, comprising administering to a subject in need thereof at least one
antagonist of
integrin alphavbeta3 and at least one other therapy. The present invention encompasses compositions and articles of manufacture for use in preventing, treating, managing or ameliorating periodontal disease, or aseptic loosening of joint replacement (prostheses), Gorham-Stout disease, Wilson's disease, chronic
otitis media, hypertrophic pulmonary osteoarthropathy or conditions associated therewith.