76 results about "Middle ear" patented technology

Techniques and apparatuses are described that perform active acoustic sensing. Provided according to one or more preferred embodiments is a hearable, such as an earbud, that is capable of performing a novel physiological monitoring process termed herein audioplethysmography, an active acoustic method capable of sensing subtle physiologically-related changes observable at a user's outer and middle ear. Instead of relying on other auxiliary sensors, such as optical or electrical sensors, audioplethysmography involves transmitting and receiving acoustic signals to monitor a user's biometrics, recognize facial behaviors, and / or sense an environment. In addition to being relatively unobtrusive, some hearables can be configured to support audioplethysmography without the need for additional hardware. As such, the size, cost, and power usage of the hearable can help make health monitoring accessible to a larger group of people and improve the user experience with hearables.

Embodiments herein relate to ear-wearable devices having acoustic port guards. In an embodiment, an ear-wearable device is included having a receiver, an acoustic channel wall defining an acoustic channel between the receiver and an acoustic channel opening, an acoustic port guard disposed at a device opening. The acoustic port guard is included having a first ring structure including a first ring portion and an insertion portion, wherein the insertion portion is configured to be inserted into the device opening. The acoustic port guard can include a plurality of ribs connected to the first ring structure with each of the plurality of ribs defining an outer portion extending beyond an outer radius of the first ring structure. Other embodiments are also included herein.

The invention provides a mouse middle ear epithelium 3D organoid and a construction method thereof, and is characterized in that the method comprises the following steps: a, taking a bubble structure of a mouse middle ear tissue, cleaning, digesting, filtering, centrifuging filtrate, collecting precipitate, and separating primary cells of the mouse middle ear; and b, inoculating the digested single cells and cell agglomerates into a 24-pore plate, wrapping with matrigel, and carrying out 3D culture, wherein a medium is a middle ear epithelium amplification medium. And culturing for about 3-5 days to obtain the mouse 3D middle ear proliferation type organoid. And performing differentiation culture by using a middle ear epithelium differentiation medium to obtain the mouse middle ear epithelium organ. According to the method, the 3D mouse middle ear epithelium organ is successfully constructed, the physiological and pathological processes of the middle ear are conveniently analyzed and researched, the interaction between the middle ear microenvironment and cells can be more accurately simulated, and the application range is wide as a model.

The present disclosure provides an endoscopic apparatus and associated methods. The apparatus may include a steerable tool having a first flexible tube concentrically nested within a second flexible tube. The apparatus may include an end cap disposed on the steerable tool, an image sensor disposed on the end cap, and one or more light sources disposed on the end cap. The apparatus may be configured for accessing a region within a middle ear cavity of a patient. As such, the apparatus may further include a flexible tube, through which the steerable tool may extend, as well as a pre-curved rigid tube, through which the flexible tube may extend, thus allowing the apparatus to be deployed for middle ear access.

Techniques and apparatuses are described that perform heart rate variability detection using a hearable. A hearable, such as an earbud, is capable of performing a novel physiological monitoring process termed herein audioplethysmography, which is an active acoustic method capable of sensing subtle physiologically-related changes observable at a user's outer and middle ear. Instead of relying on other auxiliary sensors, such as optical or electrical sensors, audioplethysmography involves transmitting and receiving acoustic signals to monitor a user's biometrics, including heart rate variability and / or blood pressure. In addition to being relatively unobtrusive, some hearables can be configured to support audioplethysmography without the need for additional hardware. As such, the size, cost, and power usage of the hearable can help make health monitoring accessible to a larger group of people and improve the user experience with hearables.

The invention relates to the technical field of crossing of medical instruments and artificial intelligence, and provides a hearing threshold detection method based on multi-mode hearing electrophysiological signal fusion. Comprising stimulation frequency otoacoustic emission and auditory brainstem response induced by sweep frequency stimulation sound, distortion product otoacoustic emission induced by dual-tone stimulation and middle ear sound immittance / reflection signals, and a multi-task deep learning model is constructed to perform fusion analysis on the signals. According to the method, accurate quantitative regression prediction of hearing thresholds with any frequency resolution and automatic classification and discrimination of hearing loss properties are synchronously realized, the problems of single evaluation dimension and insufficient complex hearing loss analysis ability in the prior art are effectively solved, the comprehensiveness, accuracy and clinical operation efficiency of objective hearing evaluation are remarkably improved, and the method is suitable for popularization and application. And an innovative system solution is provided for fine diagnosis of the auditory function.

This invention relates to drug conjugates useful for localized treatment of diseases or disorders of the middle ear and / or inner ear. Methods of treating diseases or disorders of the middle ear and / or inner ear, pharmaceutical compositions comprising the conjugates, and methods of inhibiting a Tropomyosin receptor kinase are also provided.

The utility model relates to the field of disposable hygienic products, in particular to a paper diaper lug sticker, which mainly solves the problem of poor fitness of lug stickers in the prior art, and comprises lug sticker bodies arranged on two transverse sides of a rear waistline of a paper diaper, and each lug sticker body is provided with an inner end close to one end of the paper diaper and an outer end transversely opposite to the inner end. The ear sticker body comprises a connecting piece and a sticking piece, the sticking piece is compounded at the outer end of the connecting piece, a sticking area is arranged on the surface of the sticking piece, the connecting piece comprises a connecting area, an extending area and a fitting area which are sequentially distributed from the inner end to the outer end, and the ratio of the transverse length size of the extending area to the transverse length size of the fitting area is 1: 1.2-6. The longitudinal width size of the connecting area is equal to that of the extending area, the longitudinal width size of the attaching area is smaller than that of the extending area, the attaching area is provided with a first inclined edge and a second inclined edge, and the slope of the first inclined edge is larger than that of the second inclined edge.

The invention discloses an optical fully-implanted artificial cochlea, which comprises a laser transceiving unit, a sound signal processing unit, an electrode array unit, a dual-mode coil unit and a built-in battery, and is characterized in that the laser transceiving unit is implanted into a middle ear cavity, is used for transmitting and receiving laser signals and comprises a transmitting end and a receiving end, the transmitting end continuously transmits laser to a tympanic membrane, and the receiving end is used for receiving the laser signals; the tympanic membrane vibrates to modulate the optical signal; the receiving end carries out demodulation and signal extraction on the reflected light; the sound signal processing unit is implanted under the skin behind the ear and is used for extracting and coding the characteristics of sound signals; the electrode array unit is implanted into the cochlea, and sound signals are transmitted by electrically stimulating auditory nerve elements in the cochlea; the dual-mode coil unit is implanted under the skin behind the ear and is used for wireless transmission of external signals and wireless charging energy complementation. According to the invention, efficient and fidelity transmission and processing of sound are realized, so that the existing artificial cochlea technology is thoroughly innovated, and more natural and comfortable auditory experience is provided for hearing impairment patients.

This invention relates to the field of neuroscience research and biomedical engineering experimental equipment, and discloses a stereotaxic brain localization device suitable for turtles and its usage method. The device includes an original base plate, an extended base plate assembly connected by splicing, a turtle shell limiting assembly mounted on the base plate, a curved platform, a modified semi-circular ear rod, a mouth clamp with an endotracheal intubation port, and a magnetic skull leveler. This invention expands the operating space through the extended plate and uses an arc-shaped limiting baffle to fix the turtle's position; the specially designed semi-circular ear rod adapts to the shallow concave middle ear structure of turtles, avoiding damage; the mouth clamp integrates height and length adjustment functions and has a reserved endotracheal intubation channel to maintain the experimental animal's respiration; the magnetic skull leveler can precisely adjust the head level using four corner nuts. This device enables precise localization of turtle brain regions and electrode implantation, providing stable and accurate hardware support for turtle movement regulation and neuroscience research.

The application discloses a kind of middle ear organoids culture medium and culture method, belong to organoids technical field.The middle ear organoids culture medium includes: basic culture medium, specific additive factor, CHIR99021 and TTNPB;Specific additive factor includes the following end concentration components: SB203580, 1-20 mmol / L;SB431542, 50-1000 nmol / L;Y-27632, 1-20 mmol / L;FGF-10, 10-30 μg / L;RS-246204, 1-20 nmol / mL and the like.Culture method includes: middle ear tissue is handled to obtain middle ear cell, after middle ear cell is resuspended, with matrigel is mixed, then inoculation, after it coagulates, the above-mentioned middle ear organoids culture medium is added and is cultivated, obtains middle ear organoids.The culture medium of the application can simultaneously improve the quantity and survival rate of middle ear organoids, conducive to industrialized production.

This invention discloses a device for attaching an optical element, such as an otoscope, to a smartphone for diagnosing and / or identifying problems in the outer ear, middle ear, and / or ear canal of a patient. The device may include a body. The body may include a hole and a first engagement member configured to engage with a second engagement structure belonging to the optical element. A first surface may be attached to the body and configured to contact a first smartphone surface. A piston may be provided, which may include a second surface parallel to the first surface and configured to contact a second smartphone surface. A threaded knob may be provided, connected to the piston through the hole.

The utility model relates to the field of middle ear analyser, more specifically, relate to a novel middle ear analyser positive and negative air pressure mechanical device, including air nozzle and gas supply device, the air nozzle is connected with gas supply device through the micro -adjusting air pipe, the micro -adjusting air pipe is equipped with fixed magnetic ring one side close to the air nozzle, is equipped with the sliding magnetic ring on the micro -adjusting air pipe one side close to gas supply device, the utility model discloses a novel middle ear analyser positive and negative air pressure mechanical device, relative to traditional technology, because air nozzle and gas supply device no longer directly connect, but adopt the micro -adjusting air pipe and connect, because the diameter of micro -adjusting air pipe is determined when producing, therefore only need to determine the total length of micro -adjusting air pipe and the distance of sliding magnetic ring and fixed magnetic ring, can adjust the accurate volume, because the volume is determined through the pipe length x radius square x pi, and such structural error is less, and the adjustment is convenient.

An apparatus includes a first portion configured to attach to a target middle ear portion of a recipient's body. The apparatus also includes an elongated second portion that is rigidly fixed to and extends from the first portion. The second portion has an end portion configured to be rigidly secured to a transducer assembly having a longitudinal axis. The second portion extends from the transducer assembly at an angle greater than 30 degrees relative to the longitudinal axis. The first portion and the second portion are configured to respond to a first vibration displacement of the target middle ear portion by providing a second vibration displacement to the transducer assembly. The second vibration displacement is greater than the first vibration displacement.

This invention discloses a wearable ultrasound delivery device for treating otitis media, comprising a wearable main body with a flexible structure adapted to the shape of the patient's ear canal, and a through-hole central channel; an ultrasound drug delivery device, detachably disposed within the central channel, comprising a drug carrier for carrying the therapeutic drug to be delivered, an ultrasound transducer assembly for providing an ultrasound-guided drug delivery mode, and a handheld controller for adjusting the millimeter-level displacement of the drug carrier into the middle ear cavity; wherein, the ultrasound transducer assembly comprises a flexible substrate and multiple piezoelectric transducer units integrated on the flexible substrate, the multiple piezoelectric transducer units constituting a phased array transducer array. This device solves the technical problems of inaccurate drug delivery, low drug delivery efficiency, inability to adapt to the ear canal structure, and complex operation in the prior art.

A device and method for treating a middle ear disorder in a patient includes providing to the patient an intraoral vibration device having a mouthpiece for contacting an oral cavity of the patient, wherein the intraoral vibration device has a frequency tuned to treat the middle ear disorder, and providing instructions for using the intraoral vibration device. The instructions provided for using the intraoral vibration device include placing the mouthpiece over at least one portion of the oral cavity, and applying a vibratory force at the frequency to treat the middle ear disorder.

The ear tag pliers comprise a first pliers body, a second pliers body, an elastic piece, a marking assembly and a controller, the first pliers body and the second pliers body are rotationally connected through the elastic piece, and the sides, located on the rotating portion, of the first pliers body and the second pliers body form control ends. Clamping ends and marking parts which are sequentially arranged along the direction far away from the rotating part are formed on the other sides, located on the rotating part, of the first clamp body and the second clamp body, and the marking assembly is installed on the two control ends; the animal ear is located between the two clamping parts, under the action of the elastic piece, the two clamping parts move relatively till the animal ear is clamped, at the moment, the position of the ear tag pliers is adjusted, the marking assembly is made to directly face the marking position of the animal ear, and finally the marking assembly is controlled to be started through the switch to conduct marking operation. In the process, the ear tag pliers do not need to be held by hands, so that no external force is applied to the ear tag pliers after the animal is stimulated, and the ear of the animal is prevented from being torn.

An apparatus for detecting ear structure movements or changes, or changes in pressure in the ear-canal of a user, in order to control or affect the function of an associated device. The apparatus includes a sensor apparatus capable of being worn by the user to be located in or adjacent an ear-canal of the user. The sensor apparatus includes at least one sensor being located and configured to detect and capture sensor data relating to middle ear, ear-drum complex, ear-drum margin, and / or other ear structure movements or changes of characteristics, or changes in pressure in the ear-canal of the user. A device is provided for processing and analysing sensor data from the sensor apparatus. The device analyses sensor data concerning: eye movement or directional auditory attention or focus data, and / or voluntary control data.

The utility model relates to the technical field of scalpels, and discloses a middle ear muscle cutting knife assembly which comprises a knife body and a storage box used for storing the knife body, the knife body comprises a knife handle, a knife rod and a knife head, the knife handle and the knife rod are both of a cylindrical structure, an inclined connecting rod is arranged at the end of the knife handle, the connecting rod is connected with the knife rod, and the knife head is connected with the knife rod. The tool bit is arranged at the end, away from the tool handle, of the tool bar. The whole storage box is of a square structure, the interior of the storage box is hollow, the upper portion of the storage box is open, and a cover body is arranged at the opening in a sliding mode; a plurality of groups of limiting seats are arranged on the side wall of the storage box, and the cutter bars are clamped in the limiting seats; the cutting knife provided by the utility model is used for cutting two small middle ear muscles, and the inclined connecting rod is matched with the knife rod, so that the knife head can be in a middle ear tympanic chamber when the knife handle is held by a hand, and the use is convenient; and the storage box can be used for the cutter body, so that the cutter body can be well stored, and the cutter body is prevented from being influenced by the outside.

The present invention discloses a device and method for measuring middle ear impedance for clinical audiometry research in a wide frequency range of ambient pressure, which is based on MEMS microphone technology and uses a pressure-pressure probe to measure sound pressure waves and corresponding sound velocity waves.

There is presented a hearing device for being placed at least partially in an ear canal. The hearing device includes a rechargeable battery, and at least two charging areas on the surface of the hearing device, the charging areas enabling recharging the rechargeable battery by applying a voltage from one charging area to another charging area. At least one charging area is positioned on the hearing device at the end of the hearing device facing into the middle ear during use and optionally out of contact with the walls of the ear canal during use.

An exemplary system and method are disclosed for the assessment of auditory sound conduction in the outer and middle ears in newborns and infants during the time of standard universal newborn hearing screening (UNHS) (inpatient and outpatient) in the first month of life using absorbance peak template (APT) analysis. Rather than using normative ranges showing the bounds of normal absorbance values at each frequency across frequencies, the exemplary system and method employ analysis of coherent morphological absorbance-frequency features, which are most diagnostically useful and theoretically informative, in the mid-frequency absorbance peak. The analysis can detect mid-frequency absorbance peaks in the absorbance peak template while also providing an overlay of the absorbance vs. frequency plot on the screen of the test instrument to determine key metrics in the parameters for normal absorbance peaks.

The invention relates to the technical field of nano medicines, and discloses an ATP / cerium coordination polymer nano regulator as well as a preparation method and application thereof. The invention relates to an ATP / cerium coordination polymer nano regulator. The invention relates to a self-assembly hydrogel which is prepared from raw materials including cerous nitrate (III), adenosine-5 '-disodium triphosphate, phospholipid polyethylene glycol amino, SS31 peptide and a diselenide cross-linking agent through a self-assembly and cross-linking method, can effectively remove ROS (reactive oxygen species) in an inner ear and protect cells from oxidative stress injury, thereby protecting auditory cells and improving the quality of the inner ear. The traditional Chinese medicine composition has the effect of treating hearing loss caused by oxidative stress induced by noise, can be used for treating hearing loss through middle ear cavity local administration, is simple in preparation method and mild in reaction condition, and can realize large-scale production. Cascade catalysis of cerium (III) and cerium (IV), ATP (adenosine triphosphate) energy supply and a nano system of a selenium biological material are utilized, and a novel method is provided for treating noise-induced hearing loss.

The invention belongs to the technical field of agricultural product detection. The invention particularly relates to a method for detecting the peel residue rate of fresh corn. The detection method comprises the following steps: (1) harvesting and obtaining fresh corn ears; (2) screening the fresh corn ears to obtain high-quality test ears; (3) cutting off seeds at the tips and the tails of the high-quality test clusters to obtain middle clusters; (4) stripping the grains of the middle clusters to obtain test grains; (5) mincing the test grains to obtain broken grains, and weighing the broken grains to obtain W1; washing the crushed grains to obtain seed coats, then drying and weighing W2; and (6) calculating according to a formula W2 / W1 * 100% to obtain the peel residue rate of the fresh corn. According to the method disclosed by the invention, the water content of the peel residues is ensured to be constant through a standardized operation process, particularly centrifugal dewatering treatment, the accuracy and repeatability of a detection result are remarkably improved, and a reliable quantitative basis is provided for the fresh corn industry.

The invention relates to the technical field of biomedical engineering. A middle ear fully-implanted artificial cochlea comprises a sensing part and a stimulating electrode part, and the sensing part is directly connected with the stimulating electrode part. The sensing part comprises a supporting layer, and the supporting layer is made of silicon or silicon dioxide; the sensing part further comprises piezoelectric units fixed on the supporting layer, and each piezoelectric unit comprises an upper electrode layer, a piezoelectric sensing layer made of a piezoelectric material and a lower electrode layer which are stacked in the thickness direction; the resonant frequencies of the piezoelectric units are different; the stimulating electrode part comprises platinum electrode contacts which are arranged in one-to-one correspondence with the piezoelectric units, and the platinum electrode contacts are connected with the piezoelectric units through platinum wires; the stimulating electrode part further comprises an insulating sleeve connected with the supporting layer, and the platinum electrode contacts are sequentially arranged in the length direction of the insulating sleeve. A signal processing circuit between a traditional sensing part and a stimulating electrode part is omitted, meanwhile, external power supply and an active circuit are not needed, and sound-electricity conversion is achieved purely depending on the piezoelectric effect.

Embodiments disclosed herein relate to an endoscopic device and a method to provide dynamic visualization of the middle ear. The endoscopic device includes a handle and a shaft extending therefrom. The shaft includes a rigid portion distal the handle and an articulating portion distal the rigid portion. The articulating portion is configured to articulate with respect to the rigid portion. The articulating portion includes an imaging sensor coupled thereto. The handle can include one or more actuators configured to cause the articulating portion to articulate.

Method and system for tracking of acoustic vibrations of a structural element of the middle or inner ear with optical coherence tomography using an acoustic source configured to generate an acoustic stimulus to induce vibrations of the structural element; an OCT device configured to measure a measurement signal comprising vibrographic information representative for the vibrations of the structural element in a measurement direction and an optical tracking system arranged to measure a tracking signal representative for displacements of the structural element in at least a tracking direction perpendicular to the measurement direction.

Systems and methods for detecting the occurrence of middle ear muscle activation (MEMA) events in physiological signals obtained from one or more wearable sensors, e.g., in-ear sensors, worn by an individual, and identifying one or more sleep states of the individual, e.g., REM sleep, based on the detected MEMA events are provided. Additional physiological information measured via one or more additional sensors may be used in conjunction with the signals obtained from one or more wearable sensors to identify and remove non-MEMA events, e.g., artifacts, to more accurately identify MEMA events. The identified sleep states of the individual may be graphically presented to a user via a mobile device operatively coupled to the one or more wearable sensors.

Systems and methods can be employed for access to the middle ear for delivery of a formulation to a targeted site under direct visualization. The formulation, in some cases, can be delivered to a cochlear implant lead insertion site where a lead of a cochlear implant device enters a patient's cochlea.

The utility model discloses a weight reduction type vehicle lower control box which comprises a main frame and a surrounding plate, the main frame comprises a top bearing part and a front side supporting part, the top bearing part comprises two top cross beams which are arranged in parallel, the end corner of each top cross beam is provided with an end lifting lug, and the front side supporting part is provided with a front side supporting part; two middle lifting lugs are arranged in the middle of each top cross beam at intervals; the front side supporting part comprises two vertical beams vertically connected to the front side of the top cross beam and at least one supporting vertical plate perpendicular to the top cross beam. The coaming comprises a top plate covering the top of the main frame, a bottom plate covering the bottom of the main frame, and a front side plate, a rear side plate, a left side plate and a right side plate covering the periphery of the main frame. According to the mode, the main frame is optimized through stress distribution, the bearing capacity is guaranteed, meanwhile, weight reduction is achieved, load distribution is dispersed through eight lifting lugs, stress concentration is avoided, redundant materials are reduced, the weight is further reduced, and light weight is achieved.