414 results about "Injury brain" patented technology

The invention provides an hemorrhagic brain injury intracranial pressure prediction and early warning system based on a CT image, and the system comprises a data collection module which is used for collecting the original data of a target data source of a target patient; the hybrid model comprises a 3DCNN model used for extracting hematoma spatial features of the head CT image sequence; the LSTM model is used for extracting hematoma time sequence characteristics of the physiological signals; the multi-modal fusion module is used for fusing the hematoma space features and the hematoma time sequence features and outputting hematoma fusion features; the prediction module is used for predicting an ICP sequence of the target patient in a future preset time period based on the hematoma fusion features; the self-adaptive early warning module is used for outputting a visual result based on the predicted ICP sequence in the future preset time period; and through a dynamic threshold adjustment mechanism, adjusting an early warning threshold of the target patient in combination with the case information, and triggering graded early warning in real time. Through personalized data processing and dynamic early warning, accurate, efficient and real-time patient risk management is realized.

The invention discloses a rehabilitation assisting method and device suitable for cognitive disorder treatment and a medium, and relates to medical rehabilitation. A tablet personal computer, a millimeter wave radar and the like are included, artificial intelligence technologies such as signal processing and deep learning are utilized, and rehabilitation training of patients with mild cognitive impairment caused by brain injury and cerebral apoplexy is assisted. Basic information, medical history and current cognitive conditions of the patient are recorded and collected through the tablet computer, and a rehabilitation file is generated; based on the cognitive disorder type and severity of the patient, a rehabilitation training plan is intelligently made; a patient performs rehabilitation training through a gamified training interface, and the physiological state in the training process is monitored in real time in a non-contact mode based on millimeter wave radar; a deep learning model is used for analyzing training data of the patient, and rehabilitation progress is evaluated; training and evaluation data are summarized, and a subsequent rehabilitation scheme is optimized. Full-process automatic management from patient information collection, training plan making, training implementation, rehabilitation evaluation to data analysis report generation can be rapidly and accurately achieved, and the cognitive rehabilitation efficiency and effect are improved.

The invention relates to the technical field of medical treatment, and particularly discloses a minimally invasive implantable brain-computer interface intracranial multi-mode signal monitoring system, which comprises a flexible probe, a data acquisition module, a data return module and a data analysis module, the flexible probe is embedded into the high-precision microarray electrode and the sensor to collect neural signals in real time; the data acquisition module is used for synchronously acquiring electroencephalogram signals and intracranial pressure of specific parts of the brain; the data return module manages the collected data; and the data analysis module analyzes the electroencephalogram signal and the intracranial pressure data. According to the minimally invasive implantable brain-computer interface intracranial multi-mode signal monitoring system provided by the invention, lumbar puncture enters a cerebrospinal fluid space and is sent to a target spot, so that the infection risk can be effectively reduced, the limitation on the action of a patient is reduced, and the system has the characteristics of real-time performance, directness and accuracy; the method has very important significance and value for evaluating brain injury and brain functional lesion of a patient, prognosis judgment and the like.

The invention relates to hydrogel for treating ischemic brain injury and a preparation method thereof. The hydrogel is prepared from the following raw materials: methylacryloylated hyaluronic acid, methylacryloylated gelatin, curcumin loaded HA-PPS (Hydroxypropyl-Polyphenylene Sulfite) nano-micelles and dendrobium polysaccharide loaded sodium alginate microspheres. Through combination of a nanotechnology and an intelligent response material, HA-PPS is adopted to load curcumin and sodium alginate microspheres are adopted to encapsulate dendrobium polysaccharide, so that the drug activity can be more effectively protected, the drug is protected to penetrate through a blood brain barrier and be accurately delivered to a brain injury area, and targeted release of the drug is realized; the anti-oxidation and anti-inflammatory effects are better under the combined action of the curcumin and the dendrobium polysaccharides, and meanwhile, a slow release function is also achieved.

The invention discloses application and a preparation method of exosome EGF-FGF-EXO containing double growth factors, the exosome EGF-FGF-EXO is uniform in particle size, high in loading efficiency and good in biological activity, the double growth factors comprise an epidermal growth factor EGF and a fibroblast growth factor FGF, and the epidermal growth factor EGF and the fibroblast growth factor FGF are added into the exosome EGF-FGF. The preparation method of the exosome EGF-FGF-EXO comprises preparation of an induced pluripotent stem cell (iPSC) exosome and loading of EGF-FGF, a recombinant epidermal growth factor (EGF) and a fibroblast growth factor (FGF) are loaded on the exosome from iPS-clone 12c, and the exosome product which has high biological activity and is used for treating nervous system diseases of neuroinflammation is prepared. The invention develops a brand new technical path for treatment of nervous system diseases, and in the fields of epilepsy, neurodegenerative diseases, brain injury and the like, the life quality of patients can be improved and important theoretical basis and technical support can be provided for precise medical treatment of nervous system diseases by precisely regulating and controlling neuroinflammation.

The invention provides a benzofuranone compound as well as a pharmaceutical composition and application thereof, and relates to the technical field of medicines. The benzofuranone compound is a compound as shown in a formula I, a stereoisomer thereof, a tautomer thereof, a crystalline hydrate thereof, a solvate thereof, a prodrug thereof or a pharmaceutically acceptable salt thereof. The benzofuranone compound and the pharmaceutical composition and the pharmaceutical preparation prepared from the benzofuranone compound can prevent or treat organ injury diseases, and have good treatment effects in kidney injury, liver injury, lung injury, brain injury and heart injury.

The invention discloses a traditional Chinese medicine composition for promoting blood circulation to remove meridian obstruction and application of the traditional Chinese medicine composition in preparation of a medicine for treating cerebral apoplexy. The traditional Chinese medicine composition is prepared from radix astragali, radix angelicae sinensis, lumbricus, caulis spatholobi, radix salviae miltiorrhizae, flos carthami, ramulus mori, ground beeltle, radix polygoni multiflori preparata, fructus corni, radix morindae officinalis and cortex eucommiae. A novel traditional Chinese medicine formula is obtained by optimizing compatibility on the basis of a traditional old formula, has the effects of tonifying qi, activating blood circulation, tonifying liver and kidney, dispersing blood stasis and dredging collaterals, repairs brain injury caused by cerebral apoplexy and relieves neurological function defect and brain tissue inflammation, is safe and free of drug liver injury toxicity, and is matched with precise medical treatment of western medicine, the treatment effect on cerebral apoplexy is remarkably improved, and the clinical application prospect is wide. Clinical symptoms of patients are improved, neurological function recovery is promoted, and a new Chinese and western medicine combined treatment strategy is provided for clinic.

The invention provides an ergosterol-loaded brain-targeted nano preparation and a preparation method and application thereof, and relates to the field of nano materials and nano biological medicine.The active ingredient ergosterol of the nano preparation is entrapped in a DSPE-PEG-pinacol borate nano material, and the nano material has the ROS response characteristic and can be used for preparing a brain-targeted nano preparation. The ergosterol-loaded nano preparation is in the shape of a regular sphere, is uniform in particle size, has good dispersibility and stability, has good ability of targeted therapy of cerebral arterial thrombosis diseases, effectively solves the problems of poor targeting property, low bioavailability and the like of common drugs, enhances the therapeutic effect of ergosterol on cerebral arterial thrombosis, and has good application prospects. The ergosterol can effectively improve brain injury caused by the cerebral arterial thrombosis and has a good treatment effect, meanwhile, the ergosterol serving as the active ingredient plays a role in treating the cerebral arterial thrombosis by activating a PI3K / AKT / mTOR pathway, and a new direction is provided for treatment of the cerebral arterial thrombosis.

The invention relates to the technical field of medical instruments, in particular to a sleep monitoring system based on a non-invasive brain oxygen saturation monitor, which comprises a monitoring system and is used for synchronously and dynamically monitoring local brain oxygen in real time, and the monitoring system comprises a non-invasive brain oxygen dynamic monitoring unit used for monitoring the brain blood oxygen saturation of a patient in real time by adopting a near infrared spectrum technology; the multi-parameter synchronous analysis unit is used for integrating the brain oxygen data, the electroencephalogram signals, the cerebral blood flow data and the respiratory event indexes; the intelligent risk assessment engine analyzes a brain oxygen change rule based on a deep learning algorithm, and predicts a brain function impairment risk caused by sleep breathing disorder; in the intelligent risk assessment engine, on the basis of a space-time convolutional neural network, brain oxygen time sequence data and spatial distribution characteristics are combined, and a brain hypoxia mode of the OSA patient is recognized; the method has the characteristic of realizing early warning of the brain injury related to sleep breathing disorder through noninvasive brain oxygen monitoring, multi-parameter fusion analysis and intelligent risk assessment.

The present invention relates to methods of treating a human patient suffering from brain injury. These method may comprise (starting) administering to a selected patient within a time period of ≤12 hours or within a time period of >12 hours after the occurrence of the brain injury a therapeutically effective amount of a biopterin compound such as 4-Amino-(6R,S)-5,6,7,8-tetrahydro-L-biopterin. The invention also relates to methods of increasing the value of the extended Glasgow Outcome Scale (eGOS) of patients suffering from brain injury, thereby improving the condition of the patient.

The invention provides an individualized TMS target positioning method and system for spastic cerebral palsy children, and aims to realize TMS precise nerve regulation and control for different types of SCP children. According to the method, the structural features of the healthy child are obtained, and after image processing, accurate division of the SCP child brain region is achieved, the defects of a current brain injury child brain region spectrogram are overcome, and a basis is provided for seed point selection of different SCP symptoms; multi-modal image parameter features are further scanned, whole-brain voxel correlation analysis is performed based on seed points to construct functional connection diagrams, the crossed and overlapped functional connection diagrams are searched to serve as a liability focus network of different symptoms, a voxel set close to the scalp surface serves as a TMS target, and SCP child treatment targets of different clinical symptoms are accurately positioned. Based on a focus network mapping technology, functional connection characteristics related to different symptoms or symptom complexes are better positioned, a specific brain network is identified, and an accurate intervention target is provided for TMS treatment.

The invention belongs to the technical field of damage assessment, and particularly relates to a construction method of a rat traumatic brain injury model caused by explosive shock waves. By protecting other important visceral organs except the brain, interference of damage of visceral organs such as the lung to brain injury is avoided, the overall function stability of the body is maintained, the caused brain injury can more truly reflect the characteristics of explosive traumatic brain injury, and the credibility and repeatability of experimental data are improved. The construction method simulates loading of explosion shock wave parameters in a real environment, constructs an animal traumatic brain injury model through live ammunition explosion, is closer to an actual combat environment, and can truly reflect physical parameters related to explosion and a complex action process generated by interaction of the physical parameters. And a support is provided for developing molecular mechanisms of explosive traumatic brain injury, clinical diagnosis, screening of therapeutic drugs and the like.

The invention provides an application of a TRPML1 specific small-molecule inhibitor ML-SI3 in preparation of a drug for treating or preventing brain injury. The TRPML1 specific small-molecule inhibitor ML-SI3 has the beneficial effects that the TRPML1 specific small-molecule inhibitor ML-SI3 disclosed by the invention can be used for remarkably reducing the injury degree of neurons of rats with brain injury; the learning and memory ability of rats with brain injury is improved; the dyskinesia of rats suffering from brain injury is improved, and the brain function of the rats suffering from sudden cardiac arrest and cardiopulmonary resuscitation is comprehensively protected; the TRPML1 specific small-molecule inhibitor ML-SI3 provided by the invention provides a new medicine for protecting the brain function of a patient with sudden cardiac arrest, and has good market value and clinical application prospect.

The present invention belongs to the field of rehabilitation therapy technology and discloses a longitudinal analysis method and system for magnetic resonance imaging data of mild brain injury. The method extracts BOLD signals from the magnetic resonance imaging data of subjects; constructs a symmetric positive definite sparse brain functional connectivity network set of subjects based on sparse inverse covariance matrix estimation; determines the brain functional connectivity network dictionary and sparse coefficient matrix in kernel space based on Riemannian manifold sparse coding; performs spatial distribution analysis of brain functional connectivity atomic networks; and performs longitudinal analysis of magnetic resonance imaging data of mild brain injury. By analyzing the differences in the spatial distribution of these highly present brain functional connectivity atomic networks in the brain, the present invention digs out brain functional connectivity imaging markers for distinguishing the three mild brain injury rehabilitation treatment stages: acute phase, subacute phase, and complete recovery, thereby realizing longitudinal analysis of the mild brain injury rehabilitation process.

The invention belongs to the technical field of biological medicine, discloses application of a natural protein molecule in preparation of a medicine for resisting Parkinson's syndrome, and particularly discloses a protein molecule which comprises A-B, A comprises A-chain polypeptide or functional variants of the A-chain polypeptide, and B comprises A-chain polypeptide or functional variants of the A-chain polypeptide. B comprises a B-chain polypeptide or a functional variant thereof; the A is in disulfide bridging with the B; the amino acid sequence of the A-chain polypeptide is as shown in SEQ ID NO: 1; the amino acid sequence of the B-chain polypeptide is as shown in SEQ ID NO: 2. The invention discloses a natural protein molecule and application thereof in treatment and / or prevention of Parkinson's syndrome for the first time, the protein molecule can show antioxidant capacity by activating GSH in cells and inhibiting ROS formation, and meanwhile, the protein molecule can also show antioxidant capacity by activating mitochondrial activity and anti-GFAP activity in an MPP-induced brain injury environment, so that the protein molecule can be used for treating and / or preventing Parkinson's syndrome. The natural protein molecule has the medical effect of relieving and treating Parkinson's syndrome.

The invention provides an automatic segmentation method for a focus of brain injury of a premature infant. The method comprises the following steps: preprocessing a data set; the data set is a brain MRI image of the premature brain injury patient; dividing the preprocessed data set into a training set, a test set and a verification set according to a preset proportion; building an automatic lesion segmentation network model of the brain injury of the premature infant; the network model comprises a network architecture composed of a PAFM module group, a CMSC module group and a 3D-UXNET; inputting the training set into the network model for training, and adjusting hyper-parameters based on the verification set; and inputting the test set into the trained network model to obtain an automatic lesion segmentation result of the brain injury of the premature infant corresponding to the test set. According to the method, features are extracted through multi-scale convolution of the CMSC module, and the capability of segmenting small focuses is enhanced. According to the method, multiple modal data are utilized at the same time, and modal information is fused in parallel through a hierarchical fusion strategy and a PAFM module formed by inter-modal attention and cross-modal attention, so that the segmentation performance of the model is effectively improved.

The present disclosure describes methods of administering N-acetylcysteine (NAC) via intranasal nose-to-brain administration. The effect of intranasal NAC nose-to-brain administration can be monitored using an analytical technique, for example, magnetic resonance spectroscopy (MRS). In some embodiments, intranasal nose-to-brain NAC can be used to treat a condition, for example, a brain injury.

The invention provides a brain injury prediction method and prediction system based on a multivariate feature fusion framework, and relates to the technical field of deep learning. In order to solve the problem that dynamic characteristics and static characteristics cannot be effectively fused when multivariate data damage prediction is carried out by adopting a nonlinear regression method in the prior art, dynamic characteristic data, static characteristic data, dynamic mechanical effect parameters, static influence effect parameters and brain damage degree data under various working conditions of a vehicle are obtained. A dynamic mechanical effect parameter is used as output to train a dynamic prediction model, accurate extraction of a dynamic feature time sequence rule can be ensured, a static influence effect parameter is used as output to ensure extraction of a static feature structured rule, and finally a dynamic feature vector and a static feature vector are used as input of a fusion prediction model. Fusion of a dynamic time sequence rule and a static structured rule is achieved, it is ensured that the two types of features are fully fused, and the prediction result is more accurate.

The invention relates to the technical field of intracranial pressure monitoring, in particular to a craniocerebral injury patient secondary brain injury early warning method based on multi-modal fusion, which comprises the following steps: acquiring intracranial pressure, cerebral blood flow, electroencephalogram signals and brain tissue oxygen partial pressure signals, carrying out denoising and normalization processing, constructing a multi-modal normalized time sequence data set, and carrying out multi-modal fusion on the basis of the multi-modal normalized time sequence data set; and inputting a linear discriminant analysis model to generate a time sequence difference vector, constructing a difference driving map based on a Bayesian dynamic network model, identifying abrupt change nodes, outputting a risk early warning section set, and carrying out trend stability analysis and reconstruction optimization. According to the method, the abnormal state recognition sensitivity is improved through normalized processing of multi-modal signals, enhancement of signal fusion capability, quantitative capture of direction change, reconstruction of spatial relationship between signals, modeling of dynamic transition probability, recognition of abrupt change nodes, combination of time difference vector change, evaluation of signal linkage trend, positioning of risk sections and extraction of parameter features; and the early warning and intervention precision is improved.

A method and device for reducing the damaging effects of a blast or concussive event includes applying pressure to at least one jugular vein to reduce the egress of blood from the cranial cavity during the incidence of the concussive event. Reducing blood out flow from the cranial cavity increases intracranial pressure of the cerebrospinal fluid to reduce the risk of traumatic brain injury and injuries to the spinal column. Reducing blood out flow further increases the intracranial pressure, and thereby increases the pressure of the cochlear fluid, the vitreous humor and the cerebrospinal fluid to thereby reduce the risk of injury to the inner ear, internal structure of the eye and of the spinal column. In addition, increasing intracranial pressure reduces the likelihood of brain injury and any associated loss of olfactory function.

The invention discloses a monoclonal antibody composition for resisting neurofilament light chain protein and application, the monoclonal antibody composition comprises NfL-Clone 1 and NfL-Clone 2, the amino acid sequence of a heavy chain variable region of the NfL-Clone 1 is as shown in SEQ ID NO.1, and the amino acid sequence of a light chain variable region of the NfL-Clone 1 is as shown in SEQ ID NO.2; the amino acid sequence of a heavy chain variable region of the NfL-Clone 2 is as shown in SEQ ID NO.3, and the amino acid sequence of a light chain variable region of the NfL-Clone 2 is as shown in SEQ ID NO.4. The antibody combination has the characteristics of specificity and high affinity, the NfL can be used as a brain injury biomarker, and meanwhile, the invention also provides a diagnostic detection kit of the antibody for early diagnosis of brain injury of a patient, so that the specificity and sensitivity of a diagnostic reagent are improved.

The present invention relates generally to compositions and methods useful for treating brain injuries such as stroke, optic neuropathy, traumatic brain injury, and cerebral palsy. The methods comprise administering to a subject HMC obtained by in vitro differentiation of pluripotent stem cells and / or extracellular vesicles (EV) derived from these HMCs (HMC-EV).

Systems and methods of a safety helmet for protecting the human head against repetitive impacts, moderate impacts and severe impacts so as to significantly reduce the likelihood of both translational and rotational brain injury and concussions may be provided. The helmet may include an outer shell, an outer liner disposed within and coupled to the outer shell, and an inner liner disposed within and coupled in spaced opposition to the outer liner. A damper array may allow for omnidirectional movement of the inner liner relative to the outer liner and the outer shell.

The invention discloses a silk fibroin-hyaluronic acid temperature-sensitive bioactive hydrogel scaffold, a preparation method thereof and application of the silk fibroin-hyaluronic acid temperature-sensitive bioactive hydrogel scaffold in TBI treatment, hyaluronic acid, silk fibroin and N-isopropylacrylamide are used as raw materials to construct temperature-sensitive hydrogel, and bone marrow mesenchymal stem cells (BMSCs) and paeoniflorin (PF) are loaded to form a treatment unit. Hyaluronic acid is one of components of an extracellular matrix (ECM), has high affinity to cells, and can promote proliferation of stem cells. Silk fibroin has high biocompatibility and biodegradability and good mechanical strength and ductility / toughness, and can promote tissue repair and stem cell attachment and proliferation. N-isopropylacrylamide endows the hydrogel with the characteristic of in-situ temperature-sensitive gelling. Therefore, the bioactive hydrogel stent has the advantages of components, combines the BMSCs and the PF, overcomes the obstacle that the medicine is limited by BBB to be transferred into the brain, and is implanted into a brain injury part after a TBI surgical operation to be used for repairing and treating nerve injury.

The invention relates to the technical field of walnut protein peptide modification, in particular to preparation and application of novel walnut intelligence-improving peptide, which mainly utilizes polyphenol-mediated Maillard covalent modification to weaken the bitter taste of walnut protein peptide, and controls the addition amount, reaction temperature, reaction time, pH and other external conditions of the walnut protein peptide to obtain the novel walnut intelligence-improving peptide. Screening the walnut protein intelligence-improving peptide by using indexes such as sensory evaluation and anti-oxidation characteristics; then, the influence of the modified walnut protein peptide on D-galactose induced brain injury model mice is deeply explored. Finally, the polyphenol-mediated Maillard reaction covalently modified walnut protein peptide powder is prepared by virtue of the technology, and the ingredient greatly increases the application of the walnut protein peptide in brain-strengthening and intelligence-improving products for alleviating brain injury and the like. The bitter taste of the walnut protein peptide obtained by the method is greatly reduced, and the walnut protein peptide has a potential brain protection effect.

This disclosure describes methods and systems for preventing, moderating, and / or treating brain injury. The methods herein may include obtaining a test result reflecting a condition of a brain in the subject, determining a stimulation parameter based on the test result, and stimulating a nerve based on the stimulation parameter, wherein stimulation of the nerve assists or causes contraction of a respiratory muscle in the subject. The systems herein may include a processor configured to: receive a test result reflecting a condition of a brain in a subject, and determine a stimulation parameter based on the test result; and a stimulator configured to stimulate a nerve based on the stimulation parameter, wherein stimulation of the nerve assists or causes contraction of a respiratory muscle in the subject.

The present invention generally relates to compositions and methods useful for treating a brain injury such as stroke, optic neuropathy, traumatic brain injury, and cerebral palsy. The methods include administering HMCs obtained by in vitro differentiation of pluripotent stem cells and / or extracellular vesicles (EVs) derived from such HMCs (HMC-EVs) into a subject.

The invention belongs to the field of biological medicines, and relates to application of a pharmaceutical preparation containing BAY 73-6691 or a derivative thereof in preparation of a medicine for treating brain injury diseases. Wherein the structural formula of the BAY 73-6691 is as follows: # imgabs0 #. The pharmaceutical preparation comprises the BAY 73 to 6691 and / or a pharmaceutically acceptable salt of the BAY 73 to 6691. According to the present invention, the research results show that the BAY 73-6691 can improve the ARCA brain injury through the ubiquitin phosphorylation dual pathway, such that the BAY 73-6691 may become the ARCA treatment candidate drug; the application further explains a new drug mechanism and an action target spot of the BAY 73-6691; meanwhile, a new supplement is expected to be provided in clinical application of new use of old medicines.

The invention relates to a bionic nano CO generator as well as preparation and application thereof, belongs to the technical field of medicines, and solves the problem that a CO delivery system which can synergistically promote neuroprotection and neurogenesis and has brain targeting and controlled release capabilities is urgently required to be developed at present. According to the technical scheme, the bionic nano CO generator comprises a drug-loaded particle inner core and a covering film, the drug-loaded particle inner core comprises hollow mesoporous CeO2 nano particles and MnCO loaded on the hollow mesoporous CeO2 nano particles, and the covering film is a macrophage membrane and wraps the drug-loaded particle inner core. The compound is used for apoplexy treatment administration by integrating neuroprotection and enhancing innovative dual channels of endogenous nerve growth, and is expected to significantly reduce brain injury after cerebral apoplexy and restore neurological functions so as to relieve the worry about high death rate and long-term disability after cerebral ischemia-reperfusion injury.

The invention provides application of edaravone and pharmaceutically acceptable salts thereof in prevention and / or treatment of acute high altitude diseases caused by acute plateau hypobaric hypoxia. The acute high altitude diseases include, for example, acute altitude stress (AMS), plateau acute brain injury (HACE), and plateau acute lung injury (HAPE). In addition, the present disclosure provides the use of edaravone and pharmaceutically acceptable salts thereof for the prevention and / or treatment of inflammatory responses caused by plateau pulmonary arterial hypertension (HAPH) and acute plateau hypobaric hypoxia.