188 results about "Injury brain" patented technology

The invention provides a benzofuranone compound as well as a pharmaceutical composition and application thereof, and relates to the technical field of medicines. The benzofuranone compound is a compound as shown in a formula I, a stereoisomer thereof, a tautomer thereof, a crystalline hydrate thereof, a solvate thereof, a prodrug thereof or a pharmaceutically acceptable salt thereof. The benzofuranone compound and the pharmaceutical composition and the pharmaceutical preparation prepared from the benzofuranone compound can prevent or treat organ injury diseases, and have good treatment effects in kidney injury, liver injury, lung injury, brain injury and heart injury.

The invention relates to the technical field of intracranial pressure monitoring, in particular to a craniocerebral injury patient secondary brain injury early warning method based on multi-modal fusion, which comprises the following steps: acquiring intracranial pressure, cerebral blood flow, electroencephalogram signals and brain tissue oxygen partial pressure signals, carrying out denoising and normalization processing, constructing a multi-modal normalized time sequence data set, and carrying out multi-modal fusion on the basis of the multi-modal normalized time sequence data set; and inputting a linear discriminant analysis model to generate a time sequence difference vector, constructing a difference driving map based on a Bayesian dynamic network model, identifying abrupt change nodes, outputting a risk early warning section set, and carrying out trend stability analysis and reconstruction optimization. According to the method, the abnormal state recognition sensitivity is improved through normalized processing of multi-modal signals, enhancement of signal fusion capability, quantitative capture of direction change, reconstruction of spatial relationship between signals, modeling of dynamic transition probability, recognition of abrupt change nodes, combination of time difference vector change, evaluation of signal linkage trend, positioning of risk sections and extraction of parameter features; and the early warning and intervention precision is improved.

The invention relates to a bionic nano CO generator as well as preparation and application thereof, belongs to the technical field of medicines, and solves the problem that a CO delivery system which can synergistically promote neuroprotection and neurogenesis and has brain targeting and controlled release capabilities is urgently required to be developed at present. According to the technical scheme, the bionic nano CO generator comprises a drug-loaded particle inner core and a covering film, the drug-loaded particle inner core comprises hollow mesoporous CeO2 nano particles and MnCO loaded on the hollow mesoporous CeO2 nano particles, and the covering film is a macrophage membrane and wraps the drug-loaded particle inner core. The compound is used for apoplexy treatment administration by integrating neuroprotection and enhancing innovative dual channels of endogenous nerve growth, and is expected to significantly reduce brain injury after cerebral apoplexy and restore neurological functions so as to relieve the worry about high death rate and long-term disability after cerebral ischemia-reperfusion injury.

Methods of identifying and assays designed to identify at least one biomolecule from a patient are disclosed that comprise: collecting at least one biofluid from a patient, isolating at least one exosome from the biofluid, and identifying at least one biomolecule from the at least one exosome, wherein the at least one biomolecule is bound to the at least one exosome and is locally released from the patient. In some embodiments, the at least one biomolecule comprises a secretory protein, a neurotrophic factor, a growth factor, a cytokine, a chemokine, a pre-toxic molecule, a toxic molecule, or a combination thereof.

The present invention relates to a compound of formula (I) wherein R1 is a hydrogen atom, halogen or -(C1-C2)alkyl, R2 is -halo(C1-C2)alkoxy, and R3 and R4 form together with N to which they are attached an optionally substituted 5-7 membered monocyclic heterocycloalkyl ring or an optionally substituted 8-11 membered bicyclic heterocycloalkyl ring. The present invention also relates to a medicament and a pharmaceutical composition comprising said compound of formula (I), as well as their therapeutic uses, in particular as inhibitor of NOD-like receptor protein 3 inflammasome for preventing and / or treating Parkinson's disease, frontotemporal Dementia, Multiple System Atrophy, Alzheimer's disease, Multiple Sclerosis, Amyotrophic Lateral Sclerosis or brain injury.

The application provides a craniocerebral injury simulation man teaching model, which comprises a simulation man body provided with a head, a body and limbs; the head is internally provided with a craniocerebral simulation unit for simulating brain edema, brain hematoma, brain fracture, brain hernia and cerebrospinal fluid leakage; the body is internally provided with a urinary system simulation unit, a blood circulation system simulation unit and a respiratory system simulation unit; the controller is prearranged with control programs of reactions of the urinary system simulation unit, the blood circulation system simulation unit and the respiratory system simulation unit corresponding to different brain injuries; an operator selects different brain injuries and carries out nursing on the brain injuries and the complications of the urinary system simulation unit, the blood circulation system simulation unit and the respiratory system simulation unit. The application can not only nurse the brain injuries through the craniocerebral simulation unit, but also nurse the complications of the brain injuries through the urinary system simulation unit, the blood circulation system simulation unit and the respiratory system simulation unit, so that the application is more consistent with the actual situation and is beneficial to teaching.

The application discloses a wearable brain injury local temperature control treatment device and belongs to the technical field of brain injury treatment. The device is provided with a mounting bottom plate, a rotating frame, a waste glue storage box, a moving strip, a glue coating scraper and an adjusting screw sleeve. The connecting top strip is tightly arranged on the top of the adjusting screw sleeve. The minimum distance between the glue coating scraper and the mounting bottom plate is limited. An appropriate amount of gel is applied on the edge of the temperature control sheet. The moving strip is pushed to drive the glue coating scraper to move on the top of the mounting bottom plate. The glue coating scraper pushes the gel to be applied on the top of the temperature control sheet. The gel can be uniformly applied on the surface of the temperature control sheet. The gel on the surface of the temperature control sheet is not uniformly applied. The contact between the temperature control sheet and the skin is not uniform. The heat transfer and distribution are affected. When the glue coating scraper passes through the temperature control sheet, the excess gel is pushed to flow from the top of the trapezoidal inclined block to the waste glue storage box. The excess gel is prevented from being left on the mounting bottom plate, so that the surface of the mounting bottom plate is not sticky.

The invention discloses application of selazinomethyl ether and a pharmaceutical composition thereof in preparation of a medicine for preventing or treating brain injury. The invention provides the application of selazine methyl ether in preparing the medicine for preventing or treating the brain injury for the first time, and selazine methyl ether has a remarkable effect in preventing or treating the brain injury, especially cerebral arterial thrombosis and the brain injury caused by hemorrhagic transformation of the cerebral arterial thrombosis. And cerebral injury caused by cerebral arterial thrombosis and hemorrhagic transformation can be obviously relieved. According to the application disclosed by the invention, the sefoazinomethyl ether has the effects of remarkably reducing the cerebral infarction area and behavioral scoring under the condition of middle cerebral artery occlusion; the selobezine methyl ether has the effects of remarkably reducing the hemorrhage area, hemorrhage score and behavioral score under acute high glucose and middle cerebral artery occlusion; the pharmaceutical composition containing selazine methyl ether can become a novel drug for preventing or treating brain injury, and can be used for treating various cerebrovascular diseases including cerebral arterial thrombosis and hemorrhagic transformation of cerebral arterial thrombosis.

The application discloses a new use of Leonurine or a pharmaceutically acceptable salt thereof in the preparation of a medicament for treating radiation-induced brain injury, specifically, providing a safe and effective therapeutic drug for iron death, neuroinflammation, neuron damage and lipid metabolism disorder accompanying the radiation-induced brain injury, solving the technical problem of lack of specific treatment means in the prior art, and having a wide clinical application prospect. Experiments adopt a C57BL / c mouse 30 Gy whole brain X-ray radiation model, and results show that Leonurine can significantly improve the body weight decrease and survival rate of the model mice, reduce the serum IL-6 and IFN-alpha levels, inhibit the activation of microglial cells in the cerebral cortex and hippocampus, protect and repair damaged neurons, and improve the ultrastructure of mitochondria and synapses; meanwhile, the expression of GPX4 and SLC7A11 proteins in the brain tissue is up-regulated, the GSH content is increased to inhibit iron death, and the levels of GPE, GPS and GPC related to lipid metabolism are restored.

The invention discloses an application of abscisic acid in preparation of a medicine for improving secondary brain injury after cerebral hemorrhage, the abscisic acid can relieve neuroinflammation and improve neurological function recovery by repairing microglial cell lysosome functions, enhancing phagocytic ability and promoting hematoma removal, and a new medicine strategy is provided for cerebral hemorrhage treatment.

The invention, which belongs to the technical field of the medical equipment, discloses a wake-up therapy system for frequency response through auricular vagus nerve magnetoelectricity stimulation, and the system comprises an acquisition conversion module, an anomaly detection module, a spatial modeling module, an anomaly analysis module, a stimulation application module, a monitoring adjustment module, a dynamic adjustment module and an interactive display module. According to the method, accurate analysis from electroencephalogram signals to the space level can be achieved, quantitative evaluation and visual presentation of abnormal brain functions of the patient are achieved, doctors are assisted in judging the brain function state of the patient, and scientific and accurate decision support is provided for awakening therapy of coma or brain injury patients; meanwhile, the therapeutic effect can be evaluated, stimulation parameters can be dynamically adjusted, individualized awakening intervention of the patient is promoted, the nerve over-stimulation risk of the patient is reduced, the abnormal brain area of the patient is accurately positioned, and a basis is provided for precise stimulation.

A system for component testing for head or brain injury criteria can include a vehicle seat that is substantially stationary. A dummy can be seated in the vehicle seat. The dummy can include a head and a body. An impactor can be substantially aligned with the head. An airbag can be located between the dummy and the impactor. The impactor can be caused to be projected toward a head of a dummy at a target energy, a target position, and / or with a target stroke.

The invention is applicable to the field of brain-computer interfaces and rehabilitation medicine, and provides a brain injury function training device based on a brain-computer interface, which comprises a support frame, an electroencephalogram acquisition module, a signal processing module, a training control module, a feedback module, an evaluation module and a user interaction module, in the first stage, accurate collection and preprocessing of electroencephalogram signals are achieved through a flexible electrode array and a low-noise amplification and self-adaptive noise reduction technology; secondly, through linkage of an evaluation module and a training control module, dynamic optimization of a personalized training scheme is achieved; thirdly, constructing a visual, auditory and tactile multi-mode feedback and quantitative evaluation closed loop; according to the brain injury function training device, the problems that an existing device is low in electroencephalogram signal collection precision, fixed in training scheme and lack of a training-evaluation-adjustment closed loop are solved, the accuracy, adaptability and user participation degree of brain injury function training are improved, and the brain injury function training device is suitable for function recovery training of movement, cognition, language and the like of brain injury patients with cerebral apoplexy, cerebral trauma and the like.

The invention discloses a brain injury prediction method and device based on a newborn craniocerebral ultrasound image, equipment and a medium. The method comprises the following steps: acquiring a newborn craniocerebral ultrasound video; according to the newborn craniocerebral ultrasonic video, determining an anatomical structure prediction result of each newborn craniocerebral ultrasonic video frame in the newborn craniocerebral ultrasonic video through the anatomical structure detection module; according to an anatomical structure prediction result of each newborn craniocerebral ultrasonic video frame, extracting a standard section image from the newborn craniocerebral ultrasonic video through the standard section extraction module; and according to all the extracted standard section images, outputting a predicted brain injury category through the brain injury prediction model. According to the method, standard section image extraction and brain injury category prediction are combined, and brain injury category prediction can be carried out based on the newborn craniocerebral ultrasonic video, so that a doctor does not need to manually select the section image, and the brain injury category prediction efficiency is improved.

The present invention relates to the provision of a scanning system and methods for scanning a discrete location within a body part of a subject. More particularly, the present invention provides a scanning system to scan a suspected injury in a body part of a subject, such as a brain injury. The scanning system provides a diagnostic scanning device that scans the discrete locations within the body part, and a processer configured to carry out calculating the probability of injury in each of the discrete locations; using a statistical map of the probability of injury within the body part; and the diagnostic scanning device scanning each discrete location in order of decreasing probability determined by the processor to obtain results at each discrete location; and displaying the results on a screen as the scanning continues until a clinical assessment of the injury in the body part can be made.

The application discloses a nano guanido drug system and a preparation method and application thereof, and relates to the technical field of medicine, in particular to a GCOF DHM @CAQK platform, can efficiently deliver drugs to a TBI injury site, can accumulate in a TBI brain injury area, can inhibit neuroinflammation, oxidative stress and protect neuron cells after TBI, can precisely intervene in secondary injury of TBI, and provides a new strategy for improving the prognosis of patients.

The invention discloses an application of N6022 in improving brain injury after cardiac arrest resuscitation, and particularly relates to an application of N6022 or a derivative thereof given through a nose in improving the brain injury after cardiac arrest resuscitation and increasing the survival rate after cardiac arrest resuscitation. Compared with the prior art, the application has the advantages that the increased GSNOR enzyme activity of brain tissues after sudden cardiac arrest resuscitation can be effectively inhibited by nasal injection of N6022 into a sudden cardiac arrest resuscitation rat model; the N6022 can effectively improve the neurological function after cardiac arrest resuscitation and increase the survival rate after cardio-pulmonary resuscitation; n6022 is used for inhibiting the activity of GSNOR, so that the number of survival neurons of brain tissues after sudden cardiac arrest resuscitation can be increased; the delivery mode of the N6022 through the nose can effectively enable the N6022 to enter the brain tissue of the rat. According to the invention, a new application field of N6022 is developed, and a meaningful reference is provided for improving the cerebral function after sudden cardiac arrest resuscitation.

Methods and compositions for diagnosing brain injury, neurodegeneration; or a predisposition thereto, in a subject are provided. Particularly, the present invention relates to specific antigen antibody reactivities useful in diagnosing brain injury, neurodegeneration or a predisposition thereto, in a subject.

The application discloses a brain injury identification method and an identification system. The identification system identifies the injury of a patient according to the identification method. The identification method comprises the following steps: firstly, the electrical impedance tomography (EIT) of the brain of the patient is performed to obtain the EIT image of the brain of the patient; then, the region with abnormal resistivity distribution in the EIT image of the brain is taken as a reference for scanning of a near-infrared spectrometer, and a scanning path of the near-infrared spectrometer is planned; finally, the near-infrared spectrometer is scanned along the scanning path, and the lesion range and the lesion type are determined according to the obtained near-infrared spectral data. The electrodes need not be arranged on the whole head of the patient, and the automatic and rapid identification of the lesion range and the nature of the brain injury is realized.

The present invention relates to a pharmaceutical composition comprising a pharmaceutically acceptable vehicle and non-pungent derivatives of capsaicin, in their tautomeric forms and pharmaceutically acceptable salts, as the sole active ingredient, for use in the stimulation of the sphenopalatine ganglion and the enhancement of cerebral blood flow, to prevent or reduce brain injury resulting from decreased cerebral blood flow. The composition is administered via the oral transmucosal route, preferably in the form of a mucoadhesive tablet, and may be formulated for immediate or prolonged release, ensuring effective and tolerable absorption while avoiding the irritant effects associated with pungent capsaicin.

The invention provides an after-myocardial infarction brain injury risk prediction method and system based on multi-modal data fusion, and relates to the technical field of medical information processing, and the method comprises the steps: firstly obtaining a heart image, a brain image and a brain tissue microwave echo signal of a patient; generating waveform data based on the phase difference and the amplitude difference of the echo signals; taking the heart feature data, the brain feature data and the waveform data as nodes respectively, and establishing connection edges among the nodes according to a preset clinical knowledge base to form a heterogeneous graph; processing the graph by using a graph neural network to obtain associated features; and finally, inputting the associated features into a multi-task learning model, and outputting a future brain injury risk probability and a self-regulation function damage degree result. The accuracy and comprehensiveness of myocardial infarction after-brain injury risk prediction are improved.

The invention provides a traditional Chinese medicine external application composition for treating gastroparesis after brain injury and a preparation method thereof. The traditional Chinese medicine external application composition is prepared from the following components: rhizoma acori graminei, paederia scandens, radix polygoni multiflori preparata, aloe, gastrodia elata, semen aesculi, phyllanthus emblica, stephania tetrandra, turmeric, radix fici simplicissimae, fructus piperis longi, swertia pseudochinensis, rhizoma nardostachyos, lily, ginkgo leaves and cynanchum paniculatum. Dual mechanisms of neuroprotection and gastrointestinal motility regulation are creatively fused, central nervous injury can be improved through components such as rhizoma acori graminei and radix polygoni multiflori preparata, gastrointestinal hormone secretion and slow-wave pace-making functions can be synchronously regulated through components such as paederia scandens and turmeric, and compared with a conventional single-target treatment means, the traditional Chinese medicine composition is more suitable for a complex pathological mechanism of gastric paralysis after brain injury. Meanwhile, the preparation process is simple, the cost is low, external application avoids aggravation of gastrointestinal burdens, common western medicine side effects such as arrhythmia are avoided, clinical operation is convenient, patient tolerance is good, the gastric emptying recovery time is remarkably shortened, and the risk of complications such as aspiration pneumonia is reduced.

The application discloses a structural brain injury disease intelligent classification and target recommendation system. The system comprises: an individualized brain function network construction module: according to individual resting state function images and structure images, a function connection matrix is obtained and brain function connection is represented in the form of a graph to construct an individualized brain function network; a disease judgment classification model training module: a disease judgment classification model is constructed, and the disease judgment classification model is trained by combining a network topology and a graph neural network; a key brain area identification module: the SHAP value of the K nodes with the highest SHAP value is selected by applying SHAP on the trained disease judgment classification model, and the K nodes are used as key brain areas for classification; and a personalized intervention target recommendation module: the key brain areas are registered to a standard brain space template to match recommended treatment targets. The application can more comprehensively and efficiently identify and recommend treatment targets, and provides more accurate data support for intelligent classification judgment and treatment of mental diseases.

This invention relates to the use of 5α-androsta-3β,5,6β-triol and its derivatives in the prevention or treatment of radiation-induced brain injury, and to methods for preventing or treating radiation-induced brain injury with 5α-androsta-3β,5,6β-triol and its derivatives.

Techniques for detecting embolic information for a patient. The techniques may include obtaining data identifying an ultrasound signal associated with the patient, identifying a set of candidate embolic regions in the data, identifying a set of embolic regions from among the set of candidate embolic regions, and outputting embolic information corresponding to the set of embolic regions.

The invention discloses application of chest protection in improving impact brain injury cognitive function influence, and relates to the technical field of biomedical engineering. Comprises: a rigid protective housing having a shape adapted to cover a main area of a torso of a subject; the energy dissipation inner core is borne by the rigid protective shell, is made of a polyurea polymer and is used for absorbing and dissipating impact energy through material deformation and stress dispersion when being subjected to impact wave load; and the fixing part is connected with the rigid protective shell and is used for stably fixing the chest protective device on the trunk of the object and exposing the head outside. The limitation of traditional brain injury protection is broken through, and experiments prove that under the plateau impact injury condition, non-direct injury target organs (lungs) are efficiently protected, and secondary brain injury and cognitive impairment can be remarkably relieved; the invention discloses a lung-brain interaction mechanism, and provides a brand new thought and target spot for impact injury protection.

The invention provides an electronic medical record feature extraction method based on natural language processing, and the method comprises the steps: obtaining an electronic medical record of a brain injury patient, the electronic medical record comprising preoperative brain map data, medical record text records, and postoperative brain map data; extracting medical record character records by using a natural language processing model, and determining text features; on the basis of the preoperative brain image data and the postoperative brain image data, brain region features are determined; based on data time nodes in the electronic medical record of the brain injury patient, performing feature fusion on the text features by using the preoperative brain map data and the postoperative brain map data; and based on the brain region features and the text features, determining electronic medical record features of the brain injury patient. According to the scheme, an electronic medical record is processed by using a natural language through a multi-modal data processing scheme, and the electronic medical record is further combined with the brain map features of the neural image data, so that organically combined multi-modal data features capable of being applied by an artificial intelligence technology are formed, and a foundation is laid for subsequent application.

A speckle contrast optical spectroscopy techniques for measuring cerebral blood metrics such as cerebral blood flow and / or cerebral blood volume at multiple regions of the brain using one or more light sources and detectors of a plurality of channels disposed on a headset worn by a subject and detecting a brain injury or other brain malfunction by comparing cerebral blood metrics measurement at different regions.

The invention discloses an implantable cerebral apoplexy treatment stimulator, which comprises at least two electrode parts and at least two skull nails, the at least two electrode parts are suitable for being respectively implanted into implantation holes of at least two skull, the electrode parts are connected with wires, the wires are connected with a pulse generator, each skull nail comprises a stud part and a screwing part, and the stud part is connected with the pulse generator. The stud part is suitable for being screwed into the implantation hole, the bottom of the stud part abuts against the top of the electrode part, the screwing part is connected to the top of the stud part, an operation groove is formed in the top of the screwing part, and a screw driver can be inserted into the operation groove to rotate the skull nail. The implantable cerebral apoplexy treatment stimulator is simpler in structure and more convenient to fix on the skull, the stimulation intensity can be improved, small-range lesions can be accurately targeted, stimulation is more accurate, in addition, stimulation parameters and stimulation areas can be adjusted and controlled, the implantable cerebral apoplexy treatment stimulator dynamically adapts to cerebral injury conditions of different patients, and the cerebral apoplexy treatment effect is better.