12results about How to "Promote ingrowth" patented technology

This invention discloses a hip joint prosthesis for bone defects, comprising a crescent-shaped acetabular rim filler assembly, a bone-metal defect block, an acetabular wall defect support block, a cylindrical support block, an angle pad, a locking screw, a locking nut, an assembly screw, an acetabular sealing screw, and an acetabular support block. The crescent-shaped acetabular rim filler assembly includes two sets of crescent-shaped acetabular rim fillers, which are assembled by engaging pins through pin holes. The outer circumference of the bone-metal defect block of the acetabular support block is connected to the crescent-shaped acetabular rim filler assembly via bone cement. This hip joint prosthesis for bone defects effectively fills irregular defect areas of the acetabular rim. The various screw holes and Kirschner wire holes on its surface provide multi-dimensional fixation options. The overall structure, through the synergistic action of multiple components, achieves precise reconstruction while ensuring biomechanical performance, significantly reducing the risk of postoperative prosthesis loosening and wear.

The application discloses a 3D printing ocular prosthesis platform, which is prepared through the following steps: S1, designing the shape of the ocular prosthesis platform and dividing the shape into regions; S2, selecting a porous structure for the ocular prosthesis platform in each region and determining the voxel size according to the connecting point parameters of the selected porous structure; S3, voxelizing and fitting each region to form a voxelized interface; S4, filling the porous structure selected in step S2 into each corresponding region to complete the modeling of the porous structure in each region; S5, connecting the connecting points on adjacent voxelized interfaces to each other and converting the connecting lines into solid rod models to complete the modeling of the interfaces; S6, merging the models obtained in steps S4 and S5 to obtain a final model of the ocular prosthesis platform; S7, 3D printing to obtain a bioceramic blank; and S8, high-temperature sintering of the blank to obtain a 3D printed ocular prosthesis platform after porcelain forming. The application can obtain a new 3D printed ocular prosthesis platform, which provides technical support for ocular prosthesis repair.

The present application belongs to the field of foot and ankle surgical implant devices and biomedical material surface engineering technology, and discloses a tibial component of ankle prosthesis with a composite coating, which comprises: a metal substrate which is a bionic trabecular three-dimensional interconnected porous titanium alloy structure, the porosity is 50-80%, the average pore size is 400-900 mu m, and the connected porosity is greater than or equal to 85%, so that the elastic modulus is controlled in the range of 5-20 GPa, and is matched with the cancellous bone of the tibia; a composite functional coating is in situ grown on the surface of the metal substrate, and the composite functional coating comprises a bioactive layer and a functional ion doped layer. The tibial component of the present application comprises a porous titanium alloy metal substrate and a composite functional coating constructed in situ on the surface thereof, the porous titanium alloy substrate is designed in a bionic trabecular structure to form a three-dimensional interconnected porous structure, so as to provide an elastic modulus matched with the cancellous bone of the tibia and promote the growth of bone tissue.

The present application relates to the technical field of cardiac pacing electrode, in particular to a telescopic cardiac pacing electrode, which comprises a pulse pacemaker and an electrode lead, the electrode lead comprises an insertion end, a connecting sleeve, a conductive core wire and an electrode end, the insertion end, the connecting sleeve and the electrode end are sequentially fixedly connected, the insertion end is insertedly matched with the pulse pacemaker, the connecting sleeve is internally provided with the conductive core wire, the two ends of the conductive core wire are respectively connected with the insertion end and the electrode end, and the pulse pacemaker generates a pulse electric signal which is transmitted to the inside of an organ through the electrode end; in the present application, the telescopic members and the fixing members are staggered in the subcutaneous section, the initial length is the shortest, the spacing of the fixing members anchored in the subcutaneous tissue is increased with the growth of the patient's trunk, the telescopic members are axially stretched, the length adjustment range covers the entire growth period from childhood to adulthood, the risk of electrode lead tightness, electrode displacement or breakage is fundamentally eliminated, and secondary surgery is avoided.

The application relates to the technical field of biomedical materials, and specifically discloses a preparation method of a double-crosslinked 3D-printed bone repair scaffold. The scaffold is made of a biphasic calcium phosphate matrix and a gelatin methacrylate hydrogel outer layer. The preparation method comprises the following steps: firstly, preparing biphasic calcium phosphate ink, and constructing a porous scaffold blank through 3D printing; then, carrying out double-crosslinking treatment of calcium chloride solution and glutaraldehyde solution in sequence to obtain a scaffold matrix with enhanced mechanical properties; then, preparing gelatin methacrylate hydrogel loaded with modified teriparatide, and compounding the gelatin methacrylate hydrogel with the scaffold matrix; and finally, obtaining the final product after blue light crosslinking and solidification. The bone repair scaffold has good biocompatibility and osteogenic activity, and can effectively promote bone defect repair. In addition, the preparation method is controllable and has good repeatability, the structure of the scaffold is accurately controlled through the 3D printing technology, and a new approach is provided for the preparation of personalized bone repair materials.

The application belongs to the field of biomedical materials and biomedical engineering technology, and discloses a DFO@GMs-pDA / PN composite scaffold for promoting vascularization and osteogenesis, and a preparation method and application thereof. The DFO@GMs-pDA / PN composite scaffold for promoting vascularization and osteogenesis is constructed by using electrospinning, pDA modification and emulsification-extraction technology, and by wrapping DFO into GMs and loading the DFO into a pDA surface modified PN electrospinning film. The most superficial DFO@GMs begin to disintegrate and release DFO after implantation, and the maximum drug release rate is reached after 48 hours, so as to promote the ingrowth of new blood vessels, the recruitment of stem cells and the secretion and presentation of related factors in the early stage of bone regeneration, and to provide an important blood supply basis for bone regeneration.

The utility model discloses a skull repairing mesh plate, and relates to the technical field of medical implants, the skull repairing mesh plate comprises a mesh plate main body, the mesh plate main body has a curved surface shape matched with a skull defect area; the screen plate main body is made of a composite material of polyether-ether-ketone and biphase calcium phosphate; the mesh plate main body comprises a compact area and a loose area, and the porosity of the compact area is smaller than that of the loose area; every two adjacent loose areas are separated through the corresponding dense areas, and the dense areas are staggered to form a net-shaped structure. First micropores are formed in the surface of the loose area; first through holes are formed in the compact area at intervals, and the first through holes are formed in the thickness direction of the screen plate body in a penetrating mode. The skull repairing screen plate has good mechanical properties; the bone integration capability is good; due to the lightweight design, foreign body sensation after implantation is reduced; the occurrence rate of subcutaneous hydrops can be reduced.

The application relates to the technical field of biology, and particularly discloses an artificial synthetic dermis loaded with subacromial synovial mesenchymal stem cell composite patch as well as a preparation method and application thereof. The artificial synthetic dermis loaded with subacromial synovial mesenchymal stem cell composite patch has the advantages of convenient raw material source, no immune rejection, no supply area complications, no disease transmission risk and the like. Moreover, the composite patch provides initial mechanical support, and improves the tendon-bone interface microenvironment through the paracrine effect (including pro-angiogenic related factors) of the subacromial synovial mesenchymal stem cells, promotes host cell infiltration and blood vessel ingrowth, and enhances tissue integration and rotator cuff healing.

The utility model discloses an anatomical arc-shaped ankle joint prosthesis, which belongs to the technical field of joint prostheses and comprises a first prosthesis plate, and a first coating plate is arranged on the bottom surface of the first prosthesis plate. A fixing plate is arranged on the top face of the first prosthesis plate, a second prosthesis plate is arranged on the top face of the fixing plate, and a second coating plate is arranged on the top of the second prosthesis plate. According to the arc-shaped ankle joint prosthesis, through the arrangement of the first five-star column and the second five-star column, compared with a traditional arc-shaped ankle joint prosthesis, the installation directions of the first five-star column and the second five-star column are changed through the design, so that the arc-shaped ankle joint prosthesis can be installed from a front approach, the situation that a fibula needs to be broken in a traditional operation is avoided, and operation wounds are reduced; postoperative rehabilitation is promoted, the front-back width of the ankle joint prosthesis is changed, the ankle joint prosthesis better conforms to physiological anatomy of a human body, the contact area of a bone and the prosthesis is increased, pressure borne by the surface of the prosthesis is dispersed, and prosthesis collapse caused by strength concentration is reduced.

The application relates to the field of medical devices, in particular to a polyethylene acetabular prosthesis. The polyethylene acetabular prosthesis comprises an acetabular body capable of replacing a hip bone lesion resection site and an acetabular liner; the acetabular body is provided with an ilium connecting part, a pubis connecting part and a liner connecting part; the ilium connecting part is provided with an ilium screw hole for fixing the acetabular body on the hip bone, and the pubis connecting part is provided with a pubis screw hole for fixing the acetabular body on the hip bone; the liner connecting part is used for fixing the acetabular liner; the inner wall of the acetabular liner is matched with the acetabular structure and is used for being matched with the femoral head, and the outer wall of the acetabular liner is provided with a plurality of clamping pieces used for being connected with the liner connecting part; and the liner connecting part is matched with the outer wall of the acetabular liner. The application can realize accurate replacement of the resected acetabulum of a patient while retaining the acetabular bone and the femoral head of the patient, thereby shortening the operation time and reducing the operation risk.

This invention discloses a method for parametric design of biomimetic scaffolds based on three-period minimal curved surfaces, relating to the field of biomimetic bone scaffold technology. The specific method involves selecting Gyroid(G) units in the TPMS structure within a three-period minimal curved surface structure. A bias function is designed to cause the porosity of the novel porous structure to increase incrementally along the radial direction from both the edge and center. Subsequently, the novel porous structure is imported into mechanical simulation software for mechanical performance testing, and the compression deformation behavior of each model is observed. This invention improves upon the use of general uniform porous structures as biomimetic bone scaffolds, considering the actual stress conditions of the femur during daily human activities, including not only compressive loads but also shear forces, and is applicable to all types of TPMS structures.

The present application relates to a kind of dental implants for repairing alveolar bone defect, the dental implant includes abutment, implant and side wing, three are integrally connected;The lower part of abutment is connected with the upper part of implant and is provided with side wing, the side wing is the integrated composite structure formed by reinforcing layer and porous layer.Two side wings of the dental implant are astride on alveolar bone surface, two side wings effectively disperse stress, and two side wings produce good clamping effect to alveolar bone, avoid making dental implant sink, rotate and loosen in bone alveolar bone, provide better initial stability.And the porous layer of side wing plays the role of bone graft, the shape and size of porous layer can be designed according to the shape and size of alveolar bone bone defect part.The implant of the dental implant and the porous layer of side wing have multi-scale aperture porous structure, promote bone tissue to grow into porous structure, so that implant and alveolar bone form bone integration, realize long-term biological fixation.