5results about How to "Promote ingrowth" patented technology

The present application belongs to the field of foot and ankle surgical implant devices and biomedical material surface engineering technology, and discloses a tibial component of ankle prosthesis with a composite coating, which comprises: a metal substrate which is a bionic trabecular three-dimensional interconnected porous titanium alloy structure, the porosity is 50-80%, the average pore size is 400-900 mu m, and the connected porosity is greater than or equal to 85%, so that the elastic modulus is controlled in the range of 5-20 GPa, and is matched with the cancellous bone of the tibia; a composite functional coating is in situ grown on the surface of the metal substrate, and the composite functional coating comprises a bioactive layer and a functional ion doped layer. The tibial component of the present application comprises a porous titanium alloy metal substrate and a composite functional coating constructed in situ on the surface thereof, the porous titanium alloy substrate is designed in a bionic trabecular structure to form a three-dimensional interconnected porous structure, so as to provide an elastic modulus matched with the cancellous bone of the tibia and promote the growth of bone tissue.

The application relates to the technical field of biomedical materials, and specifically discloses a preparation method of a double-crosslinked 3D-printed bone repair scaffold. The scaffold is made of a biphasic calcium phosphate matrix and a gelatin methacrylate hydrogel outer layer. The preparation method comprises the following steps: firstly, preparing biphasic calcium phosphate ink, and constructing a porous scaffold blank through 3D printing; then, carrying out double-crosslinking treatment of calcium chloride solution and glutaraldehyde solution in sequence to obtain a scaffold matrix with enhanced mechanical properties; then, preparing gelatin methacrylate hydrogel loaded with modified teriparatide, and compounding the gelatin methacrylate hydrogel with the scaffold matrix; and finally, obtaining the final product after blue light crosslinking and solidification. The bone repair scaffold has good biocompatibility and osteogenic activity, and can effectively promote bone defect repair. In addition, the preparation method is controllable and has good repeatability, the structure of the scaffold is accurately controlled through the 3D printing technology, and a new approach is provided for the preparation of personalized bone repair materials.

The application relates to the technical field of biology, and particularly discloses an artificial synthetic dermis loaded with subacromial synovial mesenchymal stem cell composite patch as well as a preparation method and application thereof. The artificial synthetic dermis loaded with subacromial synovial mesenchymal stem cell composite patch has the advantages of convenient raw material source, no immune rejection, no supply area complications, no disease transmission risk and the like. Moreover, the composite patch provides initial mechanical support, and improves the tendon-bone interface microenvironment through the paracrine effect (including pro-angiogenic related factors) of the subacromial synovial mesenchymal stem cells, promotes host cell infiltration and blood vessel ingrowth, and enhances tissue integration and rotator cuff healing.

The application relates to the field of medical devices, in particular to a polyethylene acetabular prosthesis. The polyethylene acetabular prosthesis comprises an acetabular body capable of replacing a hip bone lesion resection site and an acetabular liner; the acetabular body is provided with an ilium connecting part, a pubis connecting part and a liner connecting part; the ilium connecting part is provided with an ilium screw hole for fixing the acetabular body on the hip bone, and the pubis connecting part is provided with a pubis screw hole for fixing the acetabular body on the hip bone; the liner connecting part is used for fixing the acetabular liner; the inner wall of the acetabular liner is matched with the acetabular structure and is used for being matched with the femoral head, and the outer wall of the acetabular liner is provided with a plurality of clamping pieces used for being connected with the liner connecting part; and the liner connecting part is matched with the outer wall of the acetabular liner. The application can realize accurate replacement of the resected acetabulum of a patient while retaining the acetabular bone and the femoral head of the patient, thereby shortening the operation time and reducing the operation risk.

This invention discloses a method for parametric design of biomimetic scaffolds based on three-period minimal curved surfaces, relating to the field of biomimetic bone scaffold technology. The specific method involves selecting Gyroid(G) units in the TPMS structure within a three-period minimal curved surface structure. A bias function is designed to cause the porosity of the novel porous structure to increase incrementally along the radial direction from both the edge and center. Subsequently, the novel porous structure is imported into mechanical simulation software for mechanical performance testing, and the compression deformation behavior of each model is observed. This invention improves upon the use of general uniform porous structures as biomimetic bone scaffolds, considering the actual stress conditions of the femur during daily human activities, including not only compressive loads but also shear forces, and is applicable to all types of TPMS structures.