22results about How to "Promote ingrowth" patented technology

The invention discloses an adhesive hydrogel for oral periodontal tissue regeneration and a preparation method thereof, gelatin and polyacrylic acid are used as main raw materials, and a photo-crosslinking method is used as a basis to prepare the adhesive hydrogel; the adhesive hydrogel has good tissue adhesion, can be tightly adhered to wet soft and hard tissue surfaces, and overcomes the defect that the oral periodontal filling material is difficult to fix clinically at present. The adhesive hydrogel has high porosity after completely absorbing water and swelling, and pores in the surface and inside of the adhesive hydrogel are communicated with each other, so that the adhesive hydrogel can provide more space for growth of oral periodontal tissues, and is suitable for ingrowth of cells and regeneration of the oral periodontal tissues.

The present invention provides a method for preparing a keratinized gingival repair scaffold, wherein the active powder of biological microspheres is dispersed in a protein slurry to obtain a loose surface stock solution, which is freeze-dried together with a cell-free matrix material, and after two cross-linkings, a keratinized gingival repair scaffold with a loose surface and a dense surface is obtained. When in use, the loose surface of the porous sponge structure contacts the wound surface, which is conducive to the attachment and growth of tissue cells, and the dense surface can seal and protect the wound to a certain extent in an open healing environment. The obtained keratinized gingival repair scaffold can effectively maintain and regulate the pH environment in the oral cavity, inhibit bacteria and resist bacteria, and inhibit the growth of acid-producing bacteria such as Streptococcus mutans and bacteria with strong caries-causing properties, and at the same time has the ability to stop bleeding, promote bone growth and periodontal ligament regeneration, and inhibit periodontal epithelial regression.

The utility model belongs to the technical field of medical instruments, and particularly relates to a 3D printing lateral anterior approach interbody fusion cage which comprises an interbody fusion cage body and an insertion rod assembly arranged on the interbody fusion cage body, the insertion rod assembly comprises an insertion rod and a fixing block connected with one end of the insertion rod, and the insertion rod is arranged in an arc shape; the stability of the interbody fusion cage during initial implantation can be effectively improved through the insertion rod assembly, the interbody fusion cage is convenient to install, the fusion cage can be effectively prevented from falling off, the immediate stabilization effect is achieved, and the operation safety is improved; and the arc-shaped insertion rod facilitates installation of the insertion rod, the stability of the insertion rod can be improved, the fixing block connected with one end of the insertion rod can play a role in positioning, and the insertion rod is prevented from being hit too deep.

This invention discloses a hip joint prosthesis for bone defects, comprising a crescent-shaped acetabular rim filler assembly, a bone-metal defect block, an acetabular wall defect support block, a cylindrical support block, an angle pad, a locking screw, a locking nut, an assembly screw, an acetabular sealing screw, and an acetabular support block. The crescent-shaped acetabular rim filler assembly includes two sets of crescent-shaped acetabular rim fillers, which are assembled by engaging pins through pin holes. The outer circumference of the bone-metal defect block of the acetabular support block is connected to the crescent-shaped acetabular rim filler assembly via bone cement. This hip joint prosthesis for bone defects effectively fills irregular defect areas of the acetabular rim. The various screw holes and Kirschner wire holes on its surface provide multi-dimensional fixation options. The overall structure, through the synergistic action of multiple components, achieves precise reconstruction while ensuring biomechanical performance, significantly reducing the risk of postoperative prosthesis loosening and wear.

The application discloses a 3D printing ocular prosthesis platform, which is prepared through the following steps: S1, designing the shape of the ocular prosthesis platform and dividing the shape into regions; S2, selecting a porous structure for the ocular prosthesis platform in each region and determining the voxel size according to the connecting point parameters of the selected porous structure; S3, voxelizing and fitting each region to form a voxelized interface; S4, filling the porous structure selected in step S2 into each corresponding region to complete the modeling of the porous structure in each region; S5, connecting the connecting points on adjacent voxelized interfaces to each other and converting the connecting lines into solid rod models to complete the modeling of the interfaces; S6, merging the models obtained in steps S4 and S5 to obtain a final model of the ocular prosthesis platform; S7, 3D printing to obtain a bioceramic blank; and S8, high-temperature sintering of the blank to obtain a 3D printed ocular prosthesis platform after porcelain forming. The application can obtain a new 3D printed ocular prosthesis platform, which provides technical support for ocular prosthesis repair.

The present invention discloses an orthopedic implant with antibacterial and osteogenic properties and a preparation method thereof, which belongs to the technical field of medical materials. The titanium stent after acid treatment is placed in a NaOH solution, and a sodium titanate coating is formed on the surface of the titanium stent after alkaline heat treatment; after annealing, it is immersed in a mixed solution of EDTA-CaNa2 and NaH2PO4•2H2O, and a hydroxyapatite coating is formed on the surface of the sodium titanate coating after heating reaction; it is immersed in a mixed solution of gluconolactone and sodium alginate, and the pH of the mixed solution is controlled to be 5, and a porous hydrogel coating is formed on the surface of the hydroxyapatite coating after reaction; after immersion and loading of drugs, the orthopedic implant is obtained. The present invention sequentially forms a multilayer structure of a sodium titanate coating, a hydroxyapatite coating, and a porous hydrogel coating on a titanium alloy stent, and finally loads drugs, so that it has multiple properties such as antibacterial and osteogenic properties.

The present application belongs to the field of foot and ankle surgical implant devices and biomedical material surface engineering technology, and discloses a tibial component of ankle prosthesis with a composite coating, which comprises: a metal substrate which is a bionic trabecular three-dimensional interconnected porous titanium alloy structure, the porosity is 50-80%, the average pore size is 400-900 mu m, and the connected porosity is greater than or equal to 85%, so that the elastic modulus is controlled in the range of 5-20 GPa, and is matched with the cancellous bone of the tibia; a composite functional coating is in situ grown on the surface of the metal substrate, and the composite functional coating comprises a bioactive layer and a functional ion doped layer. The tibial component of the present application comprises a porous titanium alloy metal substrate and a composite functional coating constructed in situ on the surface thereof, the porous titanium alloy substrate is designed in a bionic trabecular structure to form a three-dimensional interconnected porous structure, so as to provide an elastic modulus matched with the cancellous bone of the tibia and promote the growth of bone tissue.

The present invention discloses a bone tissue engineering scaffold, including a hollow grid-shaped scaffold and a porous zinc-based metal ball filled therein, the porous zinc-based metal ball can be a solid ball with holes and grooves on the surface or a fluffy ball rolled by metal wire; an internal support column can also be arranged in the scaffold to provide more mechanical properties; β-TCP particles can be filled to enrich bone marrow mesenchymal stem cells. The present invention combines a grid scaffold prepared by titanium or zinc-based metal and its internal support column to prepare a bone tissue engineering scaffold with excellent mechanical properties, wherein the porous zinc-based metal ball can promote osteogenic differentiation and inhibit osteoclast differentiation, while providing support, promote the regeneration and ingrowth of bone tissue, and then gradually be replaced by bone tissue during the degradation process, and β-TCP particles can enrich mesenchymal stem cells and promote bone repair. The present invention can be applied to large bone defects in load-bearing parts, promote bone tissue regeneration on the basis of mechanical support, and achieve the therapeutic effect of repairing large bone defects.

The present application relates to the technical field of cardiac pacing electrode, in particular to a telescopic cardiac pacing electrode, which comprises a pulse pacemaker and an electrode lead, the electrode lead comprises an insertion end, a connecting sleeve, a conductive core wire and an electrode end, the insertion end, the connecting sleeve and the electrode end are sequentially fixedly connected, the insertion end is insertedly matched with the pulse pacemaker, the connecting sleeve is internally provided with the conductive core wire, the two ends of the conductive core wire are respectively connected with the insertion end and the electrode end, and the pulse pacemaker generates a pulse electric signal which is transmitted to the inside of an organ through the electrode end; in the present application, the telescopic members and the fixing members are staggered in the subcutaneous section, the initial length is the shortest, the spacing of the fixing members anchored in the subcutaneous tissue is increased with the growth of the patient's trunk, the telescopic members are axially stretched, the length adjustment range covers the entire growth period from childhood to adulthood, the risk of electrode lead tightness, electrode displacement or breakage is fundamentally eliminated, and secondary surgery is avoided.

The application relates to the technical field of biomedical materials, and specifically discloses a preparation method of a double-crosslinked 3D-printed bone repair scaffold. The scaffold is made of a biphasic calcium phosphate matrix and a gelatin methacrylate hydrogel outer layer. The preparation method comprises the following steps: firstly, preparing biphasic calcium phosphate ink, and constructing a porous scaffold blank through 3D printing; then, carrying out double-crosslinking treatment of calcium chloride solution and glutaraldehyde solution in sequence to obtain a scaffold matrix with enhanced mechanical properties; then, preparing gelatin methacrylate hydrogel loaded with modified teriparatide, and compounding the gelatin methacrylate hydrogel with the scaffold matrix; and finally, obtaining the final product after blue light crosslinking and solidification. The bone repair scaffold has good biocompatibility and osteogenic activity, and can effectively promote bone defect repair. In addition, the preparation method is controllable and has good repeatability, the structure of the scaffold is accurately controlled through the 3D printing technology, and a new approach is provided for the preparation of personalized bone repair materials.

The utility model relates to the technical field of knee joint prostheses for knee joint plasty, in particular to a tibia prosthesis for knee joint plasty, which comprises a tibia plate and a connecting part, a threading hole is arranged on the tibia plate, and the tibia prosthesis is firmly bound on a tibia by a suture through the threading hole, so that the initial fixation of the tibia prosthesis is realized; the porous coating is arranged on the connecting part, the porous structure is beneficial to ingrowth of bone tissue, the bone ingrows into the interconnecting pore channel and extends and is interwoven, so that interlocking combination is formed between the bone and the tibia prosthesis, and the long-term biological fixing effect is achieved; therefore, the whole process of implanting the tibial prosthesis into the human body is reliably fixed. In addition, the tibia prosthesis can be suitable for people with different sclerotin, and the requirement for the sclerotin of a patient is low.

The invention discloses a metal bone fracture plate with a stable bone fracture setting function, and relates to the technical field of medical apparatuses and instruments. The bone fracture plate comprises a first bone fracture plate body and a second bone fracture plate body which are symmetrically arranged, the sides, close to each other, of the first bone fracture plate body and the second bone fracture plate body are fixedly provided with an upper butt joint cylinder and a lower butt joint cylinder respectively, the upper butt joint cylinder is located at the top of the lower butt joint cylinder, and the axis of the upper butt joint cylinder and the axis of the lower butt joint cylinder are kept consistent; the sides, close to each other, of the first bone fracture plate and the second bone fracture plate are each fixedly provided with two hanging rotating sleeves. By arranging the upper butt joint cylinder and the lower butt joint cylinder, angle adjustment can be conducted on the first bone fracture plate and the second bone fracture plate firstly, then a bone fracture operation is conducted, the bone fracture plates do not need to be shaped in advance, shaping of the bone fracture plates can be completed through cooperation of the flower-shaped positioning columns, the upper butt joint cylinder and the lower butt joint cylinder, and the bone fracture effect is improved while the enough bone fracture surface is guaranteed. The preparation time before the bone setting operation is greatly shortened, and the treatment process of a patient is accelerated.

The utility model relates to the technical field of medical instruments, and discloses an acetabular prosthesis capable of adjusting the direction of a screw, which comprises an acetabular cup and a filling block connected with the acetabular cup, the acetabular cup comprises an acetabular opening and a cup body connected with the acetabular opening, the acetabular opening is round, the cup body is of a hemispherical structure matched with the acetabular opening, the cup body is of a truss type pore structure, and a sliding groove matched with the filling block is formed in the cup body; the filling block comprises a solid area and a porous area arranged on the inner side of the solid area, the porous area is of a truss type pore structure, screw grooves are formed in the filling block, and screws are movably arranged in the screw grooves. The screw is of a solid structure, and cancellous bone fixing threads are arranged on the screw. And the thickness of the cup body is 5mm. And the width of the filling block is 10mm. And the pore diameter of the truss-type pore structure of the cup body is any even number within 40-82mm. The filling block of the acetabular prosthesis can be secondarily adjusted, the position and the direction of the screw can be determined, and the requirements for the position and the direction during screw placement are met.

The application belongs to the field of biomedical materials and biomedical engineering technology, and discloses a DFO@GMs-pDA / PN composite scaffold for promoting vascularization and osteogenesis, and a preparation method and application thereof. The DFO@GMs-pDA / PN composite scaffold for promoting vascularization and osteogenesis is constructed by using electrospinning, pDA modification and emulsification-extraction technology, and by wrapping DFO into GMs and loading the DFO into a pDA surface modified PN electrospinning film. The most superficial DFO@GMs begin to disintegrate and release DFO after implantation, and the maximum drug release rate is reached after 48 hours, so as to promote the ingrowth of new blood vessels, the recruitment of stem cells and the secretion and presentation of related factors in the early stage of bone regeneration, and to provide an important blood supply basis for bone regeneration.

The utility model discloses a skull repairing mesh plate, and relates to the technical field of medical implants, the skull repairing mesh plate comprises a mesh plate main body, the mesh plate main body has a curved surface shape matched with a skull defect area; the screen plate main body is made of a composite material of polyether-ether-ketone and biphase calcium phosphate; the mesh plate main body comprises a compact area and a loose area, and the porosity of the compact area is smaller than that of the loose area; every two adjacent loose areas are separated through the corresponding dense areas, and the dense areas are staggered to form a net-shaped structure. First micropores are formed in the surface of the loose area; first through holes are formed in the compact area at intervals, and the first through holes are formed in the thickness direction of the screen plate body in a penetrating mode. The skull repairing screen plate has good mechanical properties; the bone integration capability is good; due to the lightweight design, foreign body sensation after implantation is reduced; the occurrence rate of subcutaneous hydrops can be reduced.

The application relates to the technical field of biology, and particularly discloses an artificial synthetic dermis loaded with subacromial synovial mesenchymal stem cell composite patch as well as a preparation method and application thereof. The artificial synthetic dermis loaded with subacromial synovial mesenchymal stem cell composite patch has the advantages of convenient raw material source, no immune rejection, no supply area complications, no disease transmission risk and the like. Moreover, the composite patch provides initial mechanical support, and improves the tendon-bone interface microenvironment through the paracrine effect (including pro-angiogenic related factors) of the subacromial synovial mesenchymal stem cells, promotes host cell infiltration and blood vessel ingrowth, and enhances tissue integration and rotator cuff healing.

The application provides a bone filling net bag with a double-material filling structure, which comprises an inner layer net bag and an outer layer net bag wrapped outside the inner layer net bag; a first filling cavity is formed in the inner layer net bag, and the first filling cavity is used for filling polymethyl methacrylate bone cement; an annular gap between the inner layer net bag and the outer layer net bag forms a second filling cavity, and the second filling cavity is used for filling artificial bone material; a connecting pipe is arranged on the outer surface of the inner layer net bag, the connecting pipe is connected with the first filling cavity and the second filling cavity, and is used for guiding the polymethyl methacrylate bone cement to enter the second filling cavity from the first filling cavity. The synergistic design of the structure and the material enables the implanted body to form a gradient composite interface of 'bone cement-artificial bone-host bone' in microcosm, realizes the unity of immediate stability and long-term fusion in macrocosm, and reduces the risk of postoperative implant loosening and re-fracture.

The utility model discloses an anatomical arc-shaped ankle joint prosthesis, which belongs to the technical field of joint prostheses and comprises a first prosthesis plate, and a first coating plate is arranged on the bottom surface of the first prosthesis plate. A fixing plate is arranged on the top face of the first prosthesis plate, a second prosthesis plate is arranged on the top face of the fixing plate, and a second coating plate is arranged on the top of the second prosthesis plate. According to the arc-shaped ankle joint prosthesis, through the arrangement of the first five-star column and the second five-star column, compared with a traditional arc-shaped ankle joint prosthesis, the installation directions of the first five-star column and the second five-star column are changed through the design, so that the arc-shaped ankle joint prosthesis can be installed from a front approach, the situation that a fibula needs to be broken in a traditional operation is avoided, and operation wounds are reduced; postoperative rehabilitation is promoted, the front-back width of the ankle joint prosthesis is changed, the ankle joint prosthesis better conforms to physiological anatomy of a human body, the contact area of a bone and the prosthesis is increased, pressure borne by the surface of the prosthesis is dispersed, and prosthesis collapse caused by strength concentration is reduced.

The application relates to the field of medical devices, in particular to a polyethylene acetabular prosthesis. The polyethylene acetabular prosthesis comprises an acetabular body capable of replacing a hip bone lesion resection site and an acetabular liner; the acetabular body is provided with an ilium connecting part, a pubis connecting part and a liner connecting part; the ilium connecting part is provided with an ilium screw hole for fixing the acetabular body on the hip bone, and the pubis connecting part is provided with a pubis screw hole for fixing the acetabular body on the hip bone; the liner connecting part is used for fixing the acetabular liner; the inner wall of the acetabular liner is matched with the acetabular structure and is used for being matched with the femoral head, and the outer wall of the acetabular liner is provided with a plurality of clamping pieces used for being connected with the liner connecting part; and the liner connecting part is matched with the outer wall of the acetabular liner. The application can realize accurate replacement of the resected acetabulum of a patient while retaining the acetabular bone and the femoral head of the patient, thereby shortening the operation time and reducing the operation risk.

The invention discloses a method for improving bone induction activity of bio-derived hydroxyapatite, and belongs to the technical field of medical materials. The preparation method aims at the characteristics that bio-derived hydroxyapatite has a natural three-dimensional pore structure, but is lack of bone induction activity and poor in mechanical property; according to the present invention, the biological derived hydroxyapatite is compounded with the icariin solution, and then is subjected to dual compounding with the icariin solution and the bone matrix gelatin solution so as to achieve the purposes of bone induction promotion and mechanical property strengthening. The icariin is derived from a traditional Chinese medicine herba epimedii, is a traditional kidney-tonifying and bone-strengthening traditional Chinese medicine and has the effects of improving osteoblast activity and promoting osteoblast proliferation and differentiation, and after the icariin and the hydroxyapatite composite material are implanted into a body, the bone induction activity of the hydroxyapatite can be enhanced in a short time; the bone matrix gelatin is formed by carrying out mild physical and chemical treatment on bone tissues, is mainly a mixed component of coarsely extracted I-type collagen and non-collagen, has viscosity, contains BMPs, has good bone induction activity and slow release characteristics, plays a slow release role in icariin, and improves the compressive strength of hydroxyapatite at the same time. The prepared bio-derived hydroxyapatite for improving the bone induction activity retains a natural pore structure, is good in biological safety, has the bone induction activity, is high in compressive strength, wide in source, relatively low in production cost and stable in bone induction activity, and provides a better bone repair scheme for clinic.

This invention discloses a method for parametric design of biomimetic scaffolds based on three-period minimal curved surfaces, relating to the field of biomimetic bone scaffold technology. The specific method involves selecting Gyroid(G) units in the TPMS structure within a three-period minimal curved surface structure. A bias function is designed to cause the porosity of the novel porous structure to increase incrementally along the radial direction from both the edge and center. Subsequently, the novel porous structure is imported into mechanical simulation software for mechanical performance testing, and the compression deformation behavior of each model is observed. This invention improves upon the use of general uniform porous structures as biomimetic bone scaffolds, considering the actual stress conditions of the femur during daily human activities, including not only compressive loads but also shear forces, and is applicable to all types of TPMS structures.

The present application relates to a kind of dental implants for repairing alveolar bone defect, the dental implant includes abutment, implant and side wing, three are integrally connected;The lower part of abutment is connected with the upper part of implant and is provided with side wing, the side wing is the integrated composite structure formed by reinforcing layer and porous layer.Two side wings of the dental implant are astride on alveolar bone surface, two side wings effectively disperse stress, and two side wings produce good clamping effect to alveolar bone, avoid making dental implant sink, rotate and loosen in bone alveolar bone, provide better initial stability.And the porous layer of side wing plays the role of bone graft, the shape and size of porous layer can be designed according to the shape and size of alveolar bone bone defect part.The implant of the dental implant and the porous layer of side wing have multi-scale aperture porous structure, promote bone tissue to grow into porous structure, so that implant and alveolar bone form bone integration, realize long-term biological fixation.