Degradable open porous magnesium and magnesium alloy biomaterial and preparation method thereof

A biomaterial and magnesium alloy technology, applied in the field of degradable open-pore porous magnesium and magnesium alloy biomaterials and its preparation, can solve the problems of inability to establish fusion contact points, inability to ensure pore shape uniformity, pore connectivity, etc., to achieve protection Integrity, excellent biocompatibility, and size-controllable effects

Active Publication Date: 2014-12-24
SHANGHAI INNOVATON MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in the process of powder sintering, due to the inhomogeneous particle morphology of most pore-forming agents, effective fusion contact points cannot be established between particles, so the uniformity of the pore type and the connectivity of the pores cannot be guaranteed (C.E.Wen, et al. al, Processing of biocompatible porous Ti and Mg, Scripta Materilia45(2011)1147-1153)

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  • Degradable open porous magnesium and magnesium alloy biomaterial and preparation method thereof

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Embodiment 1

[0029] This embodiment relates to a degradable open-pore porous magnesium alloy used in the field of bone tissue engineering scaffolds, with a diameter of 55 mm, a height of 50 mm, a spherical pore shape, and a pore diameter of 500-600 μm. The number of interconnected pores contained in the inner wall of a single cavity There are 5 to 10 connected pores, the diameter of the connected pores is 150 μm, and the porosity is 90%. Its structure is as figure 1 As shown, (a) is a three-dimensional schematic diagram of the degradable porous magnesium and magnesium alloy bone tissue engineering scaffold, which accurately reflects the pore characteristics described in the present invention, for example, spherical pore type and interconnected pores The hole type and their distribution characteristics; (b) The picture is the corresponding physical map, from which we can see the spherical hole type and the hole type of the connected holes distributed on the hole wall and their distribution ...

Embodiment 2

[0035]This embodiment relates to a degradable open-pore porous magnesium alloy used for bone tissue engineering scaffolds, with a diameter of 100 mm, a height of 100 mm, a cubic hole shape, and a hole diameter of 900-1000 μm. The number of connected holes contained in the inner wall of a single hole There are 3 to 5 connected pores, the diameter of the connected pores is 400 μm, and the porosity is 85%.

[0036] This embodiment relates to the aforementioned degradable open-pore porous magnesium and magnesium alloy preparation method for bone tissue engineering scaffold, the method includes the following steps:

[0037] Step 1, putting cubic sodium chloride crystal particles with a size of 900-1000 μm into a mold with an inner diameter of 100 mm and a height of 100 mm, sintering at a constant temperature of 790 ° C for 24 hours, and cooling with the furnace to obtain an open-pore porous sodium chloride prefabricated body;

[0038] Step 2, the Mg-3wt.%Nd-0.2wt.%Zn-0.5wt.%Zr-0.5w...

Embodiment 3

[0041] This example relates to a degradable open-pore porous magnesium alloy used for bone tissue engineering scaffolds, with a diameter of 200 mm, a height of 200 mm, a spherical pore shape, and a pore diameter of 700-750 μm. The number of interconnected pores contained in the inner wall of a single cavity is 6. ~10 pieces, the diameter of the connected pores is 250 μm, and the porosity is 75%.

[0042] This embodiment relates to the aforementioned degradable open-pore porous magnesium and magnesium alloy preparation method for bone tissue engineering scaffold, the method includes the following steps:

[0043] Step 1, putting spherical sodium chloride crystal particles with a size of 700-750 μm into a mold with an inner diameter of 200 mm and a height of 200 mm, sintering at a constant temperature of 700 ° C for 10 hours, and cooling with the furnace to obtain an open-pore porous sodium chloride preform;

[0044] Step 2, pouring Mg-1wt.%Y-0.5wt.%Ca alloy melt into the mold ca...

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Abstract

The invention discloses a degradable open porous magnesium and magnesium alloy biomaterial and a preparation method thereof. The magnesium and magnesium alloy biomaterial is in a completely open structure, the hole shape and size are controllable, holes are communicated by virtue of communicating holes, and the number and size of the communicating holes in hole walls are controllable; the holes are uniformly distributed and the porosity is adjustable. The preparation method comprises the following steps: sintering sodium chloride crystal particles to obtain an open porous sodium chloride prefabricated structure; pouring molten magnesium or magnesium alloy into a mould cavity with a sodium chloride prefabricated body, and performing seepage pressure casting; and removing magnesium or magnesium alloy block outer skin with the sodium chloride prefabricated body, washing with alkali, and filtering to remove sodium chloride to obtain the degradable open porous magnesium and magnesium alloy biomaterial. The preparation process is simple, convenient to perform and pollution-free; the prepared open porous structure is provided with the communicated and uniformly distributed holes, is controllable in hole shape and size, relatively high in porosity and strength, free of pore former residues and pore closing phenomenon and adjustable in degradation rate, and can serve as a new-generation degradable bone tissue engineering scaffold.

Description

technical field [0001] The invention belongs to the technical field of preparation of biomedical materials, relates to a method for designing porous materials, and relates to a biodegradable porous magnesium and magnesium alloy biomaterial used for bone tissue engineering scaffolds and a preparation method thereof. Background technique [0002] In biomedical metal materials, magnesium and magnesium alloys are considered to be one of the most attractive biomaterials due to their excellent comprehensive properties, good mechanical properties, biocompatibility and in vivo degradability of biomaterials. First, it is the material of choice for intraosseous implants, vascular stents, and dental orthopedic implants. The porous biomaterial with a three-dimensional penetrating network structure can effectively induce the growth and regeneration of bone tissue and human tissue, so that the bone implant does not loosen and fall off, and also has the characteristics of body fluid transp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C22C1/08C22C23/04C22C23/06C22C23/00A61L27/04A61L27/56A61L27/58
Inventor 袁广银贾高智丁文江
Owner SHANGHAI INNOVATON MEDICAL TECH CO LTD
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