92 results about "Bone tissue engineering" patented technology

The invention provides an interface-enhanced regenerated bone scaffold for sustained-release medicines as well as a preparation method and application of the interface-enhanced regenerated bone scaffold, and belongs to the technical field of bone tissue engineering. According to the invention, polycaprolactone and hydroxyapatite are taken as matrix components of the regenerated bone scaffold, so that the regenerated bone scaffold has mechanical strength matched with a host bone and good biocompatibility; the polydopamine coating is loaded on the surface and internal pores of the regenerated bone scaffold matrix, surface functional modification is easy to perform, and a catechol structure in the polydopamine coating can perform coordination binding with metal ions in MOFs, so that the falling rate of MOFs particles is reduced, and the MOFs particles are uniformly and stably distributed; the MOFs particles are used for loading the eucommia ulmoides extract, safety and non-toxicity are achieved, the eucommia ulmoides extract is encapsulated in the MOFs particles, the stability of the eucommia ulmoides extract can be improved, and a better drug release effect and a better bone regeneration promoting effect are achieved.

The invention provides porous biological ceramic as well as a preparation method and application thereof. The preparation method comprises the following steps: mixing aluminum oxide slurry with a pore forming agent to obtain mixed slurry; carrying out light curing reaction on the mixed slurry in a layer-by-layer projection manner by adopting DLP 3D printing, and carrying out layer-by-layer printing, accumulation and forming to obtain a ceramic body; according to the preparation method, through the aluminum oxide slurry composite pore-forming agent and the DLP 3D printing technology, it is guaranteed that no through hole exists in the material, high density and mechanical strength are maintained, and the problem that in the prior art, surface performance and mechanical performance are difficult to consider at the same time is solved; a discrete porous structure is constructed on the surface of the high-solid-content aluminum oxide ceramic, so that accurate regulation and control of the surface roughness are realized, surface discrete holes are directly formed, and a complex post-treatment process is omitted; through the sintering process, the overall sintering shrinkage rate is controlled, the forming precision of a complex structure is improved, the large-scale production requirement is met, and the material can be applied to bone tissue engineering scaffolds and tooth restoration materials.

The invention relates to the technical field of bone tissue engineering and regenerative medicine, and discloses a stem cell-loaded bionic bone scaffold material, which comprises a bone scaffold main body, the bone scaffold main body is formed by compounding hydroxyapatite and a biodegradable high-molecular polymer and has a porous structure, the porosity is 70%-90%, the aperture range is 100-500 microns, and pores are communicated with one another; a vascularization induction factor slow release system is arranged in the porous structure of the bone scaffold main body, the stem cell-loaded bionic bone scaffold material does not need to take the autologous bone of a patient, and the problems of donor injury and limited sources are avoided; the composite scaffold is matched with low-immunogenicity stem cells, so that the risks of immunological rejection and disease transmission are avoided; the material has the advantages of good biocompatibility, mechanical matching with human bones, degradability, no secondary operation, promotion of vascular regeneration and stem cell osteogenesis, and realization of bone regeneration integration.

The invention provides a developmental growth plate layered stent as well as a preparation method and application thereof, and belongs to the technical field of bone tissue engineering materials. The developmental growth plate layered stent provided by the invention is divided into three layers, the upper layer is a cartilage cell layer, the middle layer is a blood vessel barrier layer, and the lower layer is an ossification layer. The blood vessel barrier layer can be used as biological glue to bond the upper layer and the lower layer, so that the composite stent is stable in structure and not easy to break; the upper layer contains bone marrow mesenchymal stem cells (BMSCs), and the middle layer and the lower layer are free of cells. Under the condition of in-vitro chondrogenesis induction culture, the BMSCs on the upper layer can penetrate through the middle layer and be colonized on the lower layer, and in the process, part of the BMSCs can be differentiated into cartilage cells. The middle layer containing the platelet reaction protein 1 (TSP1) has a specific intervention effect on cell migration, which is expressed by inhibiting the migration of vascular endothelial cells, but has no influence on the migration of the BMSCs.

The invention discloses a high-biological-activity human-derived I-type collagen variant, a composite material based on the high-biological-activity human-derived I-type collagen variant and a preparation method. According to the invention, the COL109 fragment which can be efficiently secreted and expressed in pichia pastoris and has a triple helix structure is obtained through screening; an adhesion domain (GPP) 10 is further fused to improve the mechanical strength, and a variant COL109 (GPP) 10 is obtained; and finally, compounding with polycaprolactone (PCL) according to an optimized ratio (1: 1) to obtain the composite material with high biological activity (promoting osteogenic differentiation and wound healing) and excellent mechanical properties. The material is suitable for bone tissue engineering scaffolds, skin regeneration dressings and the like.

The invention provides a porous biological ceramic hard tissue slice as well as a preparation method and application thereof. The preparation method of the porous biological ceramic hard tissue slice comprises the following steps: preparing a hydroxyl phospholime bone restoration specimen; dehydrating and transparentizing the hydroxyapatite bone restoration specimen; carrying out permeation and embedding on the hydroxyl phospholime bone restoration specimen; carrying out block trimming and slicing on the hydroxyl phospholime bone restoration specimen; mounting the hydroxyl phospholime bone restoration specimen; through the five steps, the porous biological ceramic hard tissue slice is obtained. According to the method, the defect that a tissue-material structure is easy to damage when a biological ceramic material is treated by a traditional hard tissue slicing technology is overcome; the improved hard tissue slicing technology is suitable for research of biological ceramic materials in bone tissue engineering application.

A scaffold for bone-tissue engineering includes a mesh and a coating on the mesh. The mesh includes a plurality of offset layers of filaments of polyester. The coating covers the mesh and includes magnesium hydroxide / copper oxide nanoparticles suspended in gelatin. A method of constructing the scaffold comprises combining magnesium hydroxide / copper oxide nanoparticles with a gelatin solution and coating a polyester mesh with the combined magnesium hydroxide / copper oxide nanoparticle and gelatin solution.

The utility model relates to the technical field of medical instruments, and discloses a composite support for bone tissue engineering, which comprises a shell, a plurality of fixing rings are equidistantly mounted on the outer wall of a supporting layer, a filter screen is mounted in the middle of the outer wall of each fixing ring, and a fixing block is fixedly connected to the bottom end of each fixing ring. A bottom plate is fixedly connected to the bottom end of the fixing block, a connecting pipe is fixedly connected to the middle of the top end of the bottom plate, a plurality of second medicine outlet holes are formed in the top wall of the bottom plate at equal intervals, a second cavity is formed in the middle of the fixing block and the middle of the connecting pipe, and a first cavity is formed in the middle of the shielding layer and the middle of the supporting layer. According to the utility model, the cavity I can be filled with medicines for diminishing inflammation, relieving pain, resisting infection and promoting cartilage growth, the medicines enter the connecting tube and then flow into the adjacent cavity II from the groove, and then the medicines are guided to a fracture area through the medicine outlet II, so that smooth and rapid growth of bone tissue cells can be effectively promoted, and damaged bone tissue can be repaired.

The invention belongs to the technical field of biological materials, and particularly relates to a nano composite material for bone repair as well as a preparation method and application thereof. One of the purposes of the present invention is to provide a nano composite material for bone repair, the nano composite material comprising anthraquinone derivative molecules and metal ions forming a nano network structure, the nano network structure being formed by a carbonyl group and an alpha-phenolic hydroxyl group structure in the anthraquinone derivative molecules on the basis of the coordination of adjacent oxygen atoms to the metal ions. The nanocomposite not only shows good biocompatibility, but also can effectively promote proliferation of rat bone marrow mesenchymal stem cells (rBMSCs) and accelerate the osteogenic differentiation process, thereby having important application value in bone tissue engineering and repair medicine.

The invention belongs to the technical field of biomedical materials and bone tissue engineering, and discloses preparation and application of a self-piezoelectric aluminum nitride film / cavity assembly structure for promoting large-section critical bone defect repair. The thin film is based on the piezoelectric property of AlN, the self-power-generation capacity in the physiological vibration environment is achieved by optimizing the cavity structure, and the surface current density of AlN is remarkably improved. The film provided by the invention can continuously provide stable bio-electricity signals under the conditions of no polarization treatment and no external physical stimulation, so that the adhesion, proliferation and differentiation of osteoblasts are promoted. In-vivo experiments show that the film / cavity assembly structure can effectively repair the critical bone defect of the rabbit femur without a stent, and is superior to an existing piezoelectric material. The limitation that a traditional piezoelectric bone repair material depends on external stimulation and a stent is broken through, and an innovative strategy with high clinical transformation potential is provided for bone tissue repair.

The invention provides composite hydrogel, photo-thermal response drug release composite hydrogel as well as a preparation method and application of the photo-thermal response drug release composite hydrogel, and belongs to the technical field of biomedical materials. The hydrogel is constructed by taking methylacryloyl gelatin as a matrix and combining lauric acid microspheres carrying an osteogenesis promoting drug baicalin, a reduced graphene oxide photothermal agent and a photoinitiator LAP. Under the irradiation of near-infrared light, the hydrogel can realize local mild temperature rise, induce the lauric acid microspheres to generate solid-liquid phase change, release the entrapped osteogenesis promoting drug as required, realize the synergistic effect of photothermal therapy and controlled release of the drug, and have a good osteogenesis repair effect. The hydrogel has good mechanical properties, biocompatibility and degradability, can be used for local treatment of bone defect parts, and effectively promotes regeneration and repair of oral and maxillofacial bone tissues. The invention provides a novel controllable and efficient treatment thought for bone tissue engineering and regenerative medicine.

This invention discloses a biodegradable, highly bioactive magnesium bone particle, its preparation method, and its applications, belonging to the field of biomedical materials technology. Using magnesium bone particles as a matrix, an active composite coating layer comprising biodegradable polymer components and inorganic phase components is formed on its surface to construct biodegradable, highly bioactive magnesium bone particles. The biodegradable polymer components are one or more selected from polycaprolactone, polylactic acid, polylactic-co-glycolic acid copolymer, polyhydroxyalkanoates, chitosan, and their derivatives; the inorganic phase is one or more selected from hydroxyapatite, titanium dioxide, calcium phosphate materials, and combinations thereof. The preparation method includes magnesium bone particle matrix preparation, active composite layer slurry preparation, magnesium bone particle coating, and post-treatment. The prepared biodegradable, highly bioactive magnesium bone particles exhibit good degradation regulation performance and excellent bioactivity, and can be used in bone tissue engineering, bone defect repair, and scaffold filling fields.

The invention relates to the field of bone tissue engineering and regenerative medicine, in particular to non-denatured bone protein calcium superfine powder with bone tissue oriented growth and rapid repair effects and a preparation method and application of the non-denatured bone protein calcium superfine powder, and the non-denatured bone protein calcium superfine powder comprises the following components in percentage by weight: 25%-45% of non-denatured type I collagen, 0.005%-0.05% of bone morphogenetic protein-2, 0.001%-0.02% of transforming growth factor-beta1, 0.01%-0.02% of calcium sulfate, 0.01%-0.02% of calcium sulfate, 0.01%-0.02% of calcium The bone tissue repairing agent is prepared from, by weight, 0.001%-0.02% of basic fibroblast growth factors, 20%-40% of ultramicro hydroxyapatite nanoparticles, 5%-15% of chitosan oligosaccharide, 3%-10% of mannitol calcium complex, 2%-8% of sodium hyaluronate, 0.01%-0.1% of vitamin D3, 0.01%-0.1% of vitamin K2, 5%-15% of chondroitin sulfate, 1%-4% of casein phosphopeptides and the balance auxiliary materials, and directional growth and rapid repairing of bone tissue are promoted.

The application belongs to the technical field of bone tissue engineering, and particularly relates to a recombinant collagen-chitosan-PEG-hydroxyapatite bone repair scaffold material, a preparation method and application. The bone repair scaffold material is formed into a one-way ordered three-dimensional scaffold by a directional freezing method through recombinant collagen, chitosan and PEG. Nano-hydroxyapatite is uniformly deposited in the inside and surface through a special mineralization process. The prepared material has a very good bionic natural bone structure and composition, a good reticular structure and mechanical strength, good biocompatibility and cell activity, a significant repair effect on critical size bone defects, a good osteogenic induction effect and bone conductivity. The bone repair scaffold material provides a new potential treatment method for severe bone defects, and has a wide application in the fields of artificial bone, artificial cartilage, biological scaffolds and the like.

The application belongs to the field of biomedical materials and bone tissue engineering technology, and discloses a preparation and application of a self-piezoelectric aluminum nitride film / cavity assembly structure for promoting repair of large segment critical bone defects. The film is based on the piezoelectric properties of AlN, and through optimization of the cavity structure, self-power generation capability under a physiological vibration environment is realized, and the surface current density of AlN is significantly improved. The film can continuously provide stable bioelectric signals without polarization treatment and external physical stimulation, thereby promoting adhesion, proliferation and differentiation of osteoblasts. In vivo experiments show that the film / cavity assembly structure can effectively repair rabbit femoral critical bone defects without a scaffold, and is superior to existing piezoelectric materials. The application breaks through the limitations of traditional piezoelectric bone repair materials which depend on external stimulation and scaffolds, and provides an innovative strategy with high clinical conversion potential for bone tissue repair.

The invention relates to the technical field of biomedical tissue engineering, and particularly discloses a multi-modal response bone tissue engineering material as well as a preparation method and application thereof. The multi-mode response bone tissue engineering material is prepared by mixing methylacryloylated gelatin, sodium hyaluronate subjected to methacrylic acid esterification, 2, 4, 6-trimethylbenzoyl lithium phosphate, Michaene and nano-hydroxyapatite and then carrying out ultraviolet light cross-linking curing on the mixture. In the multi-mode response bone tissue engineering material provided by the invention, MXene has near-infrared light thermal response capability, nHAP provides release of multiple ions such as calcium, phosphorus, magnesium, strontium and the like, vascularization and osteogenic differentiation are synergistically promoted, and GelMA, HAMA and LAP provide mechanical support. Diabetes fracture animal model verification shows that the bone tissue engineering material with multi-mode response provided by the invention can significantly accelerate bone regeneration.

The invention provides a porous tissue engineering scaffold with a drug controlled release function as well as preparation and application of the porous tissue engineering scaffold. The preparation method of the porous tissue engineering scaffold comprises the following steps: S1) preparing double-layer nanoparticles by PLGA-PEG; and S2) preparing a composite scaffold by a low-temperature 3D printing technology. The stent prepared by the method has efficient drug controlled release capability, excellent mechanical properties, good biocompatibility and controllable degradation. The optimized porous structure promotes cell proliferation and tissue regeneration, meanwhile, low-temperature printing keeps the stability and activity of materials and drugs, and the material is widely applied to the fields of bone tissue engineering, local drug delivery and the like and shows remarkable clinical application value and market potential.

This invention belongs to the field of bone tissue engineering, specifically relating to a 3D printing bio-ink for bone defect repair, its preparation method, and its application. The bio-ink comprises an organic phase and an inorganic phase. The inorganic phase includes osteoinducible calcium phosphate modified with at least one of tannic acid, gelatin, chitosan, and silk fibroin. The organic phase is selected from at least one of sodium alginate, polylactic acid, polyvinyl alcohol, polycaprolactone, and polyetheretherketone. The bio-ink of this invention can better promote bone repair by eliminating foreign body reactions.

This invention relates to the field of biomedical materials technology, and more particularly to a method for preparing a hydroxyapatite bone tissue engineering scaffold, comprising the following steps: preparing acetylated or alkylated modified cellulose nanocrystals; using the modified cellulose nanocrystals as a biodispersant to synthesize hydroxyapatite; and using the synthesized hydroxyapatite to prepare a bone tissue engineering scaffold. The preparation method of this invention is simple, requires minimal experimental conditions, and does not require expensive equipment; it also does not introduce organic surfactants, and the dispersant used is essentially harmless to the environment and organisms; the prepared HA exhibits good dispersibility; and the hydroxyapatite bone tissue engineering scaffold has good biocompatibility, which is beneficial for osteoblast proliferation and differentiation, and for the structural remodeling and construction of bone defect tissue.

The application provides a polyester resin containing photoreactive dopamine and a preparation method and application thereof.The polyester resin containing photoreactive dopamine provided by the application is prepared from raw materials including dopamine methacrylamide (DMA), polypropylene fumarate (PPF), diethyl fumarate (DEF) and a photoinitiator.The dopamine molecules are integrated into the PPF crosslinking network structure through DMA, and the hydrophilicity of the material surface is significantly improved.The unsaturated polyester resin provided by the application can be applied to 3D printing technology based on face projection microstereolithography (PmuSL), the solidification forming process is simple, the three-dimensional structure is not limited, the application range is wide, and the final formed product can be used for further loading of bioactive substances, and has a wide application prospect in bone tissue engineering.The application further provides a preparation method and application of the polyester resin containing photoreactive dopamine.

The invention provides tantalum-doped beta-tricalcium phosphate nanoparticles and a preparation method and application thereof, and belongs to the technical field of biological materials.The preparation method comprises the following steps that tantalum salt is dispersed in a complexing agent solution, the pH is adjusted to be 8-10, and a tantalum complexing solution is obtained; the preparation method comprises the following steps: respectively dispersing calcium salt and phosphate in water to obtain a Ca < 2 + > solution and a PO4 < 3-> solution; dropwise adding the tantalum complexing solution into the Ca < 2 + > solution, and stirring and mixing to obtain a first mixed solution; dropwise adding a PO4 < 3-> solution into the first mixed solution, stirring and mixing to obtain a second mixed solution, carrying out a hydrothermal reaction, separating out a reaction product after the reaction is completed, and carrying out freeze drying and high-temperature calcination to obtain the tantalum-doped beta-tricalcium phosphate nanoparticles. The tantalum-doped beta-tricalcium phosphate nano-particles prepared by the method are good in mechanical property, high in corrosion resistance and excellent in biological performance, and can be widely applied to the biomedical fields of bone tissue engineering, drug loading and the like and the field of functional ceramics.

This invention discloses a method for preparing and applying a 3D-printed strong and tough silk fibroin scaffold material. The method includes: incubating silk fibroin fibers in an aqueous lithium bromide solution; modifying with glycidyl methacrylate followed by freeze-drying; obtaining a bio-ink by dissolving in an aqueous photoinitiator solution; obtaining an intermediate solution by dissolving a calcium salt in a methacryloyl phosphate compound; obtaining a photocurable bio-ink by dissolving the intermediate solution in the bio-ink; and photocuring and printing in a 3D printer to obtain the 3D-printed strong and tough silk fibroin scaffold material. This method offers advantages such as good formability, flowability compatible with 3D printers, suitability for various 3D printing modes, and rapid photocuring performance. The prepared scaffold exhibits good biocompatibility, and the printed gel material shows better mechanical properties and stability compared to SilMA, with a slower degradation rate, enabling the scaffold to be widely used in multiple fields such as bone tissue engineering.

The application discloses a kind of biomimetic composite scaffold with periosteum-cortical bone-cancellous bone structure and its preparation method and application.The scaffold is assembled by independent periosteum biomimetic scaffold module and independent bone trunk biomimetic module.The periosteum biomimetic scaffold module is cylindrical tube structure hydrogel, loaded with zinc silicate particles and periosteum related cells, with the biological functions of promoting cartilage differentiation, secreting nerve and vascular factors and synthesizing periosteum matrix proteins.The bone trunk biomimetic scaffold module is cylindrical bioceramic, with multiple vertical pipes embedded in the dense layer of outer wall to simulate cortical bone, and with staggered structure inside to simulate cancellous bone.Animal experiments show that the biomimetic composite scaffold can effectively promote the integrated regeneration of bone trunk and periosteum in rabbit radial critical size defect model.Therefore, the application provides a new solution for the biomimetic design and regeneration repair of bone tissue engineering.

The application belongs to the technical field of biomaterial ink, and particularly relates to a composite 3D printing biomaterial ink, a preparation method and application thereof. The composite 3D printing biomaterial ink comprises, by weight percentage, 12-18% of polyethylene glycol 400, 28-22% of pluronic F127 solution, and the balance of self-curing artificial bone particles; wherein the self-curing artificial bone particles are one or more of dicalcium silicate, tricalcium silicate and calcium dihydrogen phosphate. The composite biomaterial ink prepared by the application has good printability, physical and chemical properties, in-vitro degradation behavior and in-vitro biocompatibility, and has a good application prospect in the field of bone tissue engineering.

According to the graphene-based stem cell electrical stimulation differentiation device provided by the invention, a flexible graphene electrode array is adopted to release micro-current, an in-vivo bioelectric environment is simulated, and directional differentiation of stem cells to osteoblasts is promoted. The device combines electrical stimulation and impedance monitoring functions, can feed back the cell state in real time, and improves the differentiation efficiency. The graphene electrode has excellent biocompatibility, high conductivity and flexibility, and is suitable for long-term cell culture. By integrating the flexible graphene electrode, micro-current stimulation and impedance monitoring technologies, the invention provides an efficient and controllable stem cell differentiation scheme which can be applied to the fields of bone tissue engineering, regenerative medicine, drug screening and the like.

The invention discloses a porous diamond reinforced polylactic acid composite bone scaffold and a preparation method thereof, and belongs to the technical field of biomedical implants. The stent is integrally formed through a selective laser sintering technology and is composed of a polylactic acid matrix and porous diamonds uniformly dispersed in the polylactic acid matrix, and the mass fraction of the porous diamonds is 2%-16%. The surface of the porous diamond is rich in porous structures and oxygen-containing functional groups, the porous diamond and a polylactic acid matrix form a molecular bonding and mechanical interlocking synergistic enhancement interface, and the mechanical property of the polylactic acid composite bone scaffold is remarkably improved. The preparation method comprises the following steps: (1) weighing polylactic acid powder and porous diamond powder according to a set proportion, and uniformly mixing through vacuum ball milling to obtain composite powder; and (2) performing selective laser sintering on the composite powder in an argon protective atmosphere, and integrally forming to obtain the composite bone scaffold. The problem that traditional diamond particle reinforced phase interface bonding is weak is solved, and the method has wide application prospects in the field of bone tissue engineering.

The invention relates to the technical field of crossing of bone tissue engineering and intelligent antibacterial materials, in particular to a heterojunction nanocomposite and a preparation method thereof, and a heterojunction stent and a preparation method and application thereof. The preparation method comprises the following steps: by taking pCu-BTC and MoS2 as raw materials, carrying out ball milling in a dispersion medium at room temperature, then carrying out intermittent ultrasonic treatment under an ice bath condition to form a type II heterojunction interface so as to obtain a heterojunction nano composite material, compounding the heterojunction nano composite material with poly-L-lactic acid, and then carrying out high-pressure homogenization-3D printing forming, thereby obtaining the ultrasonic response type MoS2 / pCu-BTC / PLLA heterojunction scaffold. The stent has the sonodynamic / chemical dynamic dual-mode antibacterial and osteogenesis promoting functions, is good in biocompatibility and controllable in degradation, can be widely applied to the field of infectious bone defect repair, and provides a novel material solution for antibacterial-bone regeneration synergistic treatment.

The present application relates to the technical field of biomaterials and regenerative medicine, and particularly relates to a preparation method of a whole-fish-scale-based bone repair material, comprising the following steps: S1, fish scale fiber preparation: collected fish scales are washed and subjected to decellularization treatment, and then ground into fibrous form; S2, fish scale collagen adhesive preparation: collagen is extracted from the decellularized fish scales by using at least two different extraction methods, the obtained collagen products are mixed, freeze-dried, and then dissolved in deionized water to prepare collagen adhesives with different concentrations; S3, composite material preparation: the collagen adhesive prepared in step S2 is mixed with the fish scale fibers obtained in step S1, and then extruded into a shape; the whole-fish-scale-based bone tissue engineering material can be prepared by combining fish scale collagen and fish scale fibers, the material is not only safer and more reliable in composition, but also allows accurate regulation of the composition, thereby providing more innovative possibilities for the application of fish scale collagen adhesive.

This invention belongs to the field of bone tissue engineering, and particularly relates to a 3D-printed scaffold with improved bioactivity and high strength, and its preparation method. The method includes the following steps: 3D printing a bio-ink to form a scaffold; the bio-ink comprises an organic phase and an inorganic phase, the inorganic phase comprising osteoinductive calcium phosphate modified with at least one of tannic acid, gelatin, quaternized chitosan, and silk fibroin; the organic phase is selected from at least one of sodium alginate, polylactic acid, polyvinyl alcohol, polycaprolactone, and polyetheretherketone; the mass ratio of the inorganic phase to the organic phase is 1:(0.5-2). The scaffold prepared by this invention exhibits high strength and bioactivity.

The application belongs to the technical field of material chemistry, and discloses a kind of trans-aromatic fumarate copolymer and its preparation method and application, the trans-aromatic fumarate copolymer has the structure general formula shown in formula (I), and the number average molecular weight is greater than 8000 g / mol;Its preparation method is with phthalic anhydride, 1,8-naphthalene dicarboxylic anhydride or glutamic anhydride and maleic anhydride, propylene oxide is raw material, under the catalysis of 2,6-di-tert-butyl-4-methyl phenol magnesium, with benzyl alcohol as initiator, carry out ring-opening copolymerization reaction to form cis-aromatic fumarate copolymer, then isomerization is obtained, because main chain contains aromatic rigid unit, with high molecular weight, stable structure, high photocuring activity, good mechanical property, biodegradable and other advantages, can be prepared suitable for biomedical field biodegradable photocuring 3D printing photosensitive resin, for bone tissue engineering, personalized implant body and other fields, has good application prospect.