13 results about "Hydroxyapatite nanoparticles" patented technology

The invention provides a composite sun-screening agent based on an encapsulation technology as well as a preparation method and application of the composite sun-screening agent. The preparation method of the composite sun-screening agent comprises the following steps: fully dispersing hydroxyapatite nanoparticles in an alkaline solvent, adding a dopamine monomer, and carrying out oxidative polymerization reaction, centrifugal washing and drying to obtain HAP-PDA composite nanoparticles; and fully dispersing the HAP-PDA composite nanoparticles in a solvent, adding a mixed solution of a chemical sun-screening agent and an antioxidant and a surfactant, and performing encapsulation reaction and centrifugation to obtain the product. According to the invention, a polydopamine and hydroxyapatite composite encapsulation technology is innovatively adopted, so that the stability and biocompatibility of the sun-screening agent and the antioxidant are remarkably improved, the sun-screening effect is enhanced, and the product is endowed with a lasting sun-screening effect and excellent oxidation resistance. According to the invention, the limitation of a traditional sunscreen product is broken through, and safer, more efficient and more comfortable sunscreen experience can be provided for consumers.

The invention discloses a gradient degradation type personalized absorbable sternum fracture fixing plate and a preparation process, and belongs to the technical field of medical implant materials. Comprising an anatomical adaptive plate body and an integrated locking assembly, the plate body is of a partitioned structure of a middle supporting area and an edge buffering area, a gradient pore array penetrating through the thickness direction is formed in the surface of the plate body, and a hydroxyapatite-collagen composite coating is loaded on the inner wall of a pore; the plate body is made of a composite absorbable material through 3D printing forming and hot pressing post-treatment, and the composite absorbable material comprises, by weight, 60%-70% of polylactic acid-glycolic acid copolymer (PLGA, LA / GA = 75 / 25), 15%-20% of silanized magnesium alloy microwires, 5%-10% of hydroxyapatite nano-particles and 5%-10% of polycaprolactone (PCL). Space-time matching of the degradation rate and the bone healing process is achieved through the partition gradient structure, the magnesium alloy microwires enhance the mechanical property and release active ions to promote osteogenesis, and the method has the advantages of personalized adaptation, gradient degradation, bone regeneration promotion and the like.

This invention belongs to the field of biomedical materials technology, specifically disclosing a composite material for promoting the repair of soft tissue defects in the maxillofacial region and its preparation method. The composite material comprises the following raw materials: oxidized hyaluronic acid, carboxymethyl chitosan, dopamine-functionalized hydroxyapatite nanoparticles, strontium salt, copper salt, glycerol, and deionized water. The preparation method includes: firstly, strontium salt and copper salt are hierarchically loaded onto the surface of dopamine-functionalized hydroxyapatite nanoparticles via a dual mechanism of "lattice substitution-surface coordination," and then, together with oxidized hyaluronic acid and carboxymethyl chitosan, construct a "dynamic covalent-hydrogen bond-coordination bond" triple synergistic network through Schiff base reaction, hydrogen bonding, and coordination bonds. This invention solves the technical problems of poor wet surface adhesion, low mechanical strength, single function, and easy burst release of ions in existing repair materials, exhibiting excellent effects such as sequential antibacterial and repair-promoting properties, high adhesion strength, and long-lasting sustained release.

The invention discloses a rapid-absorption collagen repair membrane and a preparation method thereof, and relates to the technical field of biological materials. The repairing membrane is of a double-layer structure and comprises a purified collagen layer and an absorbable polymer spinning layer loaded with inorganic nanoparticles. The preparation method comprises the following steps: purifying animal skin to obtain a purified collagen layer; the preparation method comprises the following steps: respectively dispersing akermanite and hydroxyapatite nanoparticles, and mixing; adding the mixed dispersion liquid into the absorbable polymer solution to obtain a composite spinning solution; spinning the composite spinning solution on the surface of the collagen layer by adopting an electrostatic spinning method to form a spinning layer; and drying to obtain the repairing film. According to the invention, by regulating and controlling the variety, proportion, crystallinity and spatial distribution of the inorganic particles, the synergistic enhancement of mechanical properties and biological activity is realized, so that the repair film has pH-responsive graded release ability, can automatically adjust degradation behavior according to inflammation intensity, actively adapts to microenvironment, and has good application prospects. The method can be widely applied to the fields of oral soft tissue repair, periodontal wound covering and the like.

The invention discloses injectable hydrogel for treating periodontitis as well as a preparation method and application of the injectable hydrogel. The injectable hydrogel is prepared from the following raw materials: chitosan and derivatives thereof, oxidative modified natural polysaccharide and modified hydroxyapatite, the modified hydroxyapatite comprises hydroxyapatite, and the surface of the hydroxyapatite is modified with a metal polyphenol network. The modified hydroxyapatite has multiple functions of oxidation resistance, immunoregulation, osteogenesis promotion, migration promotion, tube formation promotion, antibiosis and the like, and can be combined with the injectable hydrogel with biological adhesion and self-healing performance to realize better in-vivo tissue healing. The injectable hydrogel of the composite functional hydroxyapatite nanoparticles synthesized by the invention has biocompatibility, oxidation resistance, immunoregulation performance, osteogenesis promotion performance and antibacterial performance, and can realize better alveolar bone regeneration and repair in a rat periodontitis model, and the effect of the injectable hydrogel is superior to that of clinically common minocycline.

The application discloses a kind of based on HAP nano-modified composite fiber filter membrane and its preparation method and application, it is related to the field of insulating oil filtration processing.Preparation method is in hydroxyapatite nanoparticle join alkali solution, 3-glycidyloxypropyl trimethoxysilane reaction preparation surface-modified hydroxyapatite nanoparticle, subsequently with PTFE powder, dispersant is mixed and dispersed to obtain spinning solution, composite fiber filter membrane is prepared using electrostatic spinning machine.The composite fiber filter membrane prepared in the application is doped with surface-modified hydroxyapatite nanoparticle, can efficiently adsorb aging acidic substances in vegetable insulating oil, meanwhile, the filter membrane is intercepted and captured to other micro-impurities, effectively reduces the impurity content in vegetable insulating oil to realize purification, so as to reduce the dielectric loss factor and viscosity of vegetable insulating oil, improve aging life and insulation performance.

The invention discloses iron tailing powder-slag powder co-doped concrete and a preparation method thereof, and belongs to the technical field of concrete materials. The invention aims to solve the problem that concrete for an intertidal zone bank protection structure is difficult to adapt to composite working conditions of high-salt soaking, tidal scouring, wave impact and silt abrasion. The concrete is prepared from the following components in parts by mass: 30 to 40 parts of P.O 42.5 ordinary Portland cement, 35 to 50 parts of modified iron tailing powder, 15 to 28 parts of superfine slag powder, 2 to 6 parts of steel slag-based nano calcium-lignosulfonate grafted composite powder, 2.0 to 4.0 parts of desulfurized gypsum, 1.0 to 3.0 parts of lithium slag powder, 0.5 to 1.5 parts of hydrated calcium aluminate, 0.8 to 2 parts of modified hydroxyapatite nano powder and 105 to 130 parts of modified iron tailing aggregate, 0.4-1.2 parts of basalt fibers, 0.7-1.5 parts of a polycarboxylic acid type high-efficiency water reducing agent, 0.1-0.5 part of a modified konjac glucomannan-polyether amine copolymer and the like. Through the synergistic effect of multiple components, intertidal zone composite working condition erosion can be effectively resisted, the long-term service requirement of a revetment structure is met, and meanwhile the resource utilization rate of solid waste such as iron tailings is increased.

The invention relates to the technical field of dental and orthopedic implants, in particular to a zirconia osseointegration implant material and a preparation method thereof. Aiming at the problems of strong biological inertness and slow early-stage osseointegration of the zirconium oxide ceramic surface, the preparation method comprises the following steps: cleaning a zirconium oxide matrix and carrying out alkaline activation; forming a polydopamine adhesion bottom layer; branched polyethyleneimine is fixed to enhance the amino density; constructing a network layer through alternate coordination of phytic acid and calcium / strontium ions; strontium doped hydroxyapatite nano particles are immobilized; finally, biomimetic mineralization is carried out in simulated body fluid. According to the method, a micro-nano composite active interface is formed, the biological activity, ion release controllability and osseointegration capability of the material are remarkably improved, and osteoblast response is promoted.

The invention provides a pH-responsive slow-release zinc-phosphorus nano-fertilizer as well as a preparation method and application thereof. The pH-responsive slow-release zinc-phosphorus nano-fertilizer is prepared from the following raw materials: zinc ion-loaded hydroxyapatite and chitosan, the chitosan is at least partially coated on the hydroxyapatite loaded with the zinc ions; the pH-responsive slow-release zinc-phosphorus nano-fertilizer slowly releases zinc and phosphorus elements under the condition that the pH is 4-6. According to the invention, the multi-nutrient nano phosphate fertilizer with pH response of chitosan-coated zinc-loaded hydroxyapatite nanoparticles is developed by constructing nano hydroxyapatite as a carrier, and compared with the traditional phosphate fertilizer, the multi-nutrient nano phosphate fertilizer not only can greatly reduce phosphorus loss and negative influence on the environment, but also can be used as a plant modifier to promote the growth of plants.

This invention discloses an antibacterial and bioactive composite film layer on the surface of a zirconium-based amorphous alloy, its preparation method, and its application, belonging to the technical field of biomedical zirconium alloy coating materials. Hydroxyapatite nanoparticles and strontium are introduced into the micro-arc oxidation process. Hydroxyapatite (HA) possesses excellent osteoconductivity, osteointegration capacity, osteoinductive properties, and biocompatibility; strontium plays a unique role as a "bidirectional regulator of bone metabolism" in biomedical materials. Furthermore, the incorporation of Cu endows the micro-arc oxidation film layer with broad-spectrum and long-lasting antibacterial capabilities. This invention generates a composite film layer with both antibacterial and bioactive properties on the surface of a zirconium-based amorphous alloy through a single micro-arc oxidation step, enhancing its overall service performance in physiological environments.

This invention discloses a soil conditioner with water retention, air permeability, and microbial loading functions, and its preparation method. The conditioner comprises a composite water-retaining resin, a composite air-permeable carrier, functional microbial agents, a microbial agent protectant, hydroxyapatite nanoparticles, and humic acid. The composite water-retaining resin is obtained by cross-linking konjac glucomannan with acrylamide and sulfonic acid monomers. The composite air-permeable carrier is a composite calcined mixture of mesoporous silica and diatomaceous earth. The microbial agent protectant is a complex of trehalose and chitosan. In preparation, each component is prepared separately, the microbial agent is loaded onto the composite air-permeable carrier, and finally, all components are mixed and molded. This conditioner synergistically achieves soil water retention and air permeability, prolongs the survival period of microorganisms, adsorbs heavy metals, and increases soil organic matter, solving the problems of single function and poor adaptability of existing conditioners, and is suitable for the field of soil improvement.

The present application relates to the technical field of biomedical materials, and particularly relates to a modified LDH composite material and application thereof in bone regeneration and treatment of bone tumors. The modified LDH composite material is prepared by the following steps: firstly, zinc-calcium-molybdenum hydrotalcite nanosheets are synthesized by a coprecipitation method; then the hydrotalcite nanosheets are subjected to alkali etching; yeast is loaded on the etched zinc-calcium-molybdenum nanosheets to induce intracellular mineralization of hydroxyapatite nanoparticles and promote bone regeneration; meanwhile, the strength of collagen fiber gel is enhanced in situ, and the bone mineralization process is simulated; the yeast can destroy the glycolysis of tumor cells, consume glucose and lactic acid, and combine with efficient SDT to induce ICD, destroy the immunosuppressive microenvironment in the tumor area, and activate T cells; and the yeast has excellent anti-tumor and bone repair performance.

The application relates to a method for preparing hydroxyapatite nanoparticles through high-speed shearing and synergic double reverse-phase fine emulsion, which continuously acts on the emulsification, mixing and homogenization process of a weakly alkaline precursor solution containing a calcium salt and an oil phase system and a precursor solution containing a phosphate and an oil phase system (constituting double reverse-phase fine emulsion droplets), and the collision-mixing reaction process of the calcium salt in the subsequent dispersed phase emulsion droplet (water droplet) and the phosphate in another dispersed phase emulsion droplet (water droplet), realizes the continuous operation of the high-speed shearing effect to intensify the physical emulsification mixing process and the chemical reaction mixing process, and achieves the purpose of preparing nHAP with good dispersity, small size and narrow particle size distribution; the method has simple preparation process, low equipment requirement, low cost, mild reaction condition, easy control in the preparation process, and is easy to enlarge, effectively solves the problems of low yield, high cost, use of a large amount of solvent in the process, easy harm to human body and environment, and difficulty in realizing large-scale production in the prior art.