4 results about "Hydroxyapatite nanoparticles" patented technology

This invention belongs to the field of biomedical materials technology, specifically disclosing a composite material for promoting the repair of soft tissue defects in the maxillofacial region and its preparation method. The composite material comprises the following raw materials: oxidized hyaluronic acid, carboxymethyl chitosan, dopamine-functionalized hydroxyapatite nanoparticles, strontium salt, copper salt, glycerol, and deionized water. The preparation method includes: firstly, strontium salt and copper salt are hierarchically loaded onto the surface of dopamine-functionalized hydroxyapatite nanoparticles via a dual mechanism of "lattice substitution-surface coordination," and then, together with oxidized hyaluronic acid and carboxymethyl chitosan, construct a "dynamic covalent-hydrogen bond-coordination bond" triple synergistic network through Schiff base reaction, hydrogen bonding, and coordination bonds. This invention solves the technical problems of poor wet surface adhesion, low mechanical strength, single function, and easy burst release of ions in existing repair materials, exhibiting excellent effects such as sequential antibacterial and repair-promoting properties, high adhesion strength, and long-lasting sustained release.

This invention discloses an antibacterial and bioactive composite film layer on the surface of a zirconium-based amorphous alloy, its preparation method, and its application, belonging to the technical field of biomedical zirconium alloy coating materials. Hydroxyapatite nanoparticles and strontium are introduced into the micro-arc oxidation process. Hydroxyapatite (HA) possesses excellent osteoconductivity, osteointegration capacity, osteoinductive properties, and biocompatibility; strontium plays a unique role as a "bidirectional regulator of bone metabolism" in biomedical materials. Furthermore, the incorporation of Cu endows the micro-arc oxidation film layer with broad-spectrum and long-lasting antibacterial capabilities. This invention generates a composite film layer with both antibacterial and bioactive properties on the surface of a zirconium-based amorphous alloy through a single micro-arc oxidation step, enhancing its overall service performance in physiological environments.

The present application relates to the technical field of biomedical materials, and particularly relates to a modified LDH composite material and application thereof in bone regeneration and treatment of bone tumors. The modified LDH composite material is prepared by the following steps: firstly, zinc-calcium-molybdenum hydrotalcite nanosheets are synthesized by a coprecipitation method; then the hydrotalcite nanosheets are subjected to alkali etching; yeast is loaded on the etched zinc-calcium-molybdenum nanosheets to induce intracellular mineralization of hydroxyapatite nanoparticles and promote bone regeneration; meanwhile, the strength of collagen fiber gel is enhanced in situ, and the bone mineralization process is simulated; the yeast can destroy the glycolysis of tumor cells, consume glucose and lactic acid, and combine with efficient SDT to induce ICD, destroy the immunosuppressive microenvironment in the tumor area, and activate T cells; and the yeast has excellent anti-tumor and bone repair performance.

The application relates to a method for preparing hydroxyapatite nanoparticles through high-speed shearing and synergic double reverse-phase fine emulsion, which continuously acts on the emulsification, mixing and homogenization process of a weakly alkaline precursor solution containing a calcium salt and an oil phase system and a precursor solution containing a phosphate and an oil phase system (constituting double reverse-phase fine emulsion droplets), and the collision-mixing reaction process of the calcium salt in the subsequent dispersed phase emulsion droplet (water droplet) and the phosphate in another dispersed phase emulsion droplet (water droplet), realizes the continuous operation of the high-speed shearing effect to intensify the physical emulsification mixing process and the chemical reaction mixing process, and achieves the purpose of preparing nHAP with good dispersity, small size and narrow particle size distribution; the method has simple preparation process, low equipment requirement, low cost, mild reaction condition, easy control in the preparation process, and is easy to enlarge, effectively solves the problems of low yield, high cost, use of a large amount of solvent in the process, easy harm to human body and environment, and difficulty in realizing large-scale production in the prior art.