24 results about "Bone replacement" patented technology

Disclosed are platelet-derived extracellular vesicles (EVs), and composite materials comprising them, for use as bone replacement material and / or as bone rebuilding material. Also, methods of production, medical uses and kits are disclosed.

The invention of the gradient porous structured sacral prosthesis and the manufacturing process aims to create an alternative replacement for bone loss in patients who require bone replacement. The gradient porous structured sacral prosthesis consists of an artificial bone fragment, a metal rod, and a set of screws for fixing the fragments. The manufacturing process consists of seven steps: Identifying the position and boundaries of the bone, First-step topology optimization, Second-step topology optimization, Defining the structural pattern and unit cell size, Designing the artificial bone implant, Mechanical performance testing of the implant, and Fabrication of the sacral implant. The devices and processes according to the present invention are clearly sequenced and characterized. Modification or change in the manufacturing sequence or use may reduce the capabilities of the present invention or make it unusable for the purposes of the present invention.

Disclosed are platelet-derived extracellular vesicles (EVs), and composite materials comprising them, for use as bone replacement material and / or as bone rebuilding material. Also, methods of production, medical uses and kits are disclosed.

Provided is a total talar replacement prosthesis that has a metallic body shell and a metallic or biologic core, where the metallic body shell includes one or both of a removable calcaneus attachment and a removable navicular attachment. The attachments, when removed, exposes a respective calcaneus-facing surface or a navicular-facing surface that can enhance fusion to the respective bones, calcaneus and / or navicular.

The invention discloses beta-tricalcium phosphate-based photocuring formed ceramic slurry and a preparation method thereof, and the beta-tricalcium phosphate-based photocuring formed ceramic slurry comprises the following components in parts by volume: 66-75 parts of modified ceramic powder, 25-30 parts of a resin premixed solution, and a dispersant accounting for 10-20% of the mass fraction of the modified ceramic powder, the modified ceramic powder is a KH560 or KH570 modified ceramic powder body; the mass ratio of the beta-tricalcium phosphate to the hydroxyapatite to the 3Y-TZP is (4-10): (2-6): 1, and the average particle size of the beta-tricalcium phosphate is 6-12 [mu] m and / or 1-4 m; the average particle size of the HA particles is 1-4 m and / or 300-500 nm; the average particle size of the 3Y-TZP particles is 300 to 500 nm and / or 80 to 120 nm. The high solid content, the high dispersion stability and the good rheological property are guaranteed, meanwhile, degreasing sintering densification is considered, the mechanical stability of a green body is effectively improved, the density and the mechanical property of a sintered body are optimized, meanwhile, the good biocompatibility and the biological activity of beta-TCP are reserved, and therefore the requirements of high-standard medical application such as bone repair and bone replacement are met.

Graft for a bone defect, in particular a tibial head graft for a knee-joint endoprosthesis. It comprises a sleeve-like inner body (2) for implantation at one end of a long bone (99). An outer face of the inner body (2) is designed as a bone contact face (20) for bearing on the surrounding bone margin (97). According to the invention, an outer shell piece (3) is provided which, as a bone replacement piece, is doubled onto the outside of the inner body (2) for filling a defect at the cortical bone margin (97) and is not dimensioned peripherally, such that, in the circumferential direction, it covers only a part of the outer circumference of the inner body (2). The doubled outer shell piece (3) forms a filler piece for a bone defect (bone window 96) at the bone end. Closure of the bone window (96) is achieved, and unwanted contact between the graft and surrounding soft-tissue parts is avoided. Moreover, the graft is thus also supported in the region of the bone window (96). Parts of the bone margin (97) that are still present can thus remain intact, allowing the greatest possible preservation of naturally present bone substance.

Disclosed herein are systems and methods for planning a knee arthroplasty procedure. A method may include registration of patient anatomy, including specific registration of the patella; anatomy modelling based on the registration; automated generation of anatomical landmarks; morphological characterization; risk classification; and a planning optimization process based on the morphological characterization and the risk classification. The risk classification may include a determination of potential patellar complications based on patient characteristics, such as patient demographic information and / or patient anatomical information compared with historical information of patient outcomes. The planning optimization process may determine knee implant components and / or the configuration thereof within the patient based on the patient risk classification.

This invention provides a method, apparatus, storage medium, and device for real-time debugging of animation skeletons, comprising: acquiring an animation skeleton sent by a first terminal and a first bone replacement file sent by a second terminal; extracting a first interface marker from the first bone replacement file; traversing all interface markers contained in the animation skeleton to determine a second interface marker that matches the first interface marker; overwriting the bone code portion corresponding to the second interface marker with the first bone replacement file to obtain a debugged animation skeleton; sending the debugged animation skeleton to the first terminal; and publishing the debugged animation skeleton after receiving debugging confirmation information from the first terminal. By receiving debugging of local bones of the animation skeleton from different functional terminals at the engine end, the debugging efficiency of different functional terminals for the same animation skeleton is improved.

The invention discloses a preparation method and application of a bionic ceramic material based on a bacterial cellulose template. The preparation method comprises four steps of template culture, template purification, mineralization treatment and drying forming. The method comprises the following steps: firstly, accurately constructing a bacterial cellulose hydrogel template with a layered porous structure in a normal-temperature and normal-pressure liquid environment by adopting a biosynthesis method; and secondly, purifying the template to serve as a biomimetic mineralization substrate, regulating and controlling the crystallization process (including crystal form, size and orientation) of inorganic minerals by virtue of the layered confinement space of the template at normal temperature and normal pressure, and finally drying to obtain the high-toughness ceramic material with the biomimetic multilevel structure. High temperature and high pressure are not needed in the whole process, and energy consumption is remarkably reduced. The obtained bionic ceramic material has high strength (700-1700 MPa) and high modulus (21-55 GPa), and can be applied to the fields of dental restoration, bone replacement, energy-saving building materials and the like.

The invention relates to the technical field of turning devices, and provides a turning device for a blank bar material for bone replacement part production, which comprises a machine tool rack, a machine tool body fixedly mounted on the machine tool rack, a lathe body mounted on the machine tool body, a feeding assembly, a chuck, an upper sliding frame, a turnover clamping assembly, a mounting groove, an auxiliary centering assembly and a feeding rack, the feeding assembly is installed on the lathe body, the chuck is detachably installed at the output end of the lathe body, the upper sliding frame is fixedly installed on the inner top wall of the machine tool rack, the overturning clamping assembly is installed on the upper sliding frame, an installation groove is formed in the lathe body, the auxiliary centering assembly is installed in the installation groove, and the feeding rack is detachably installed at the tail of the machine tool rack. According to the technical scheme, the problems that in the prior art, due to the fact that the clamping position of the blank bar is inconvenient to determine during feeding, the blank bar vibrates in the machining process, and the blank bar is difficult to stably clamp rapidly are solved.

1. Name of the designed product: femoral prosthesis. 2. Use of the designed product: the designed product is used for hip joint femoral replacement. 3. Design points of the designed product: in shape. 4. Picture or photo best indicating the design points: perspective view 1.

The utility model belongs to the technical field of medical apparatus and instruments, and particularly relates to a positioning measuring scale for an ossicular replacement prosthesis, which is mainly used in an ossicular replacement prosthesis operation and mainly comprises a base with a top end face; the measuring rod is arranged on the top end face of the base, the axis of the measuring rod is perpendicular to the top end face, and the measuring rod is provided with an identification structure; the method mainly solves the problem that the length of the ossicular is improperly selected due to the fact that the selected ossicular prosthesis depends on experience and naked eyes when the artificial ossicular is selected in the middle ear microsurgery. The device has the effects of measuring the distance between the tympanic membrane and the hammer bone of a patient and the stapes base plate / the distance between the tympanic membrane and the stapes so as to select an ossicular prosthesis with a proper length for implantation in an operation, ensuring the stability of the ossicular prosthesis after being placed, improving the sound transmission effect and reducing complications.

[Problem] To provide a wet apatite porous body and a wet apatite curable composition exhibiting excellent bone conduction and bone replacement properties, and wet apatite and related materials for regenerating cartilage. Another problem is to provide an apatite-based curable composition, a calcium phosphate composition, a calcium carbonate composition, supporting bodies, and the like necessary to provide the abovementioned, and related manufacturing methods. [Solution] This problem has been solved by discovering a wet apatite porous body, a wet apatite curable composition, a wet apatite composition and related materials for regenerating cartilage, and manufacturing methods for these.

Graft for a bone defect, in particular a tibial head graft for a knee-joint endoprosthesis. It comprises a sleeve-like inner body (2) for implantation at one end of a long bone (99). An outer face of the inner body (2) is designed as a bone contact face (20) for bearing on the surrounding bone margin (97). According to the invention, an outer shell piece (3) is provided which, as a bone replacement piece, is doubled onto the outside of the inner body (2) for filling a defect at the cortical bone margin (97) and is not dimensioned peripherally, such that, in the circumferential direction, it covers only a part of the outer circumference of the inner body (2). The doubled outer shell piece (3) forms a filler piece for a bone defect (bone window 96) at the bone end. Closure of the bone window (96) is achieved, and unwanted contact between the graft and surrounding soft-tissue parts is avoided. Moreover, the graft is thus also supported in the region of the bone window (96). Parts of the bone margin (97) that are still present can thus remain intact, allowing the greatest possible preservation of naturally present bone substance.

This invention discloses a 3D-printed scaffold with improved bioactivity and in vitro mineralization capacity, its preparation method, and its applications. The scaffold is prepared by layer-by-layer extrusion 3D printing using an ink comprising biphasic calcium phosphate (composed of octacalcium phosphate (OCP) and amorphous calcium phosphate (ACP)), sodium alginate, and a dispersant. This invention uses a mixture of OCP and ACP to form biphasic calcium phosphate (BCP) as the inorganic phase component of the 3D composite scaffold, and sodium alginate (SA) as the organic phase component. Simultaneously, the organic substance sodium alginate (SA) can simulate a blood clot as a temporary matrix, providing mechanical stability and traction for cells migrating from adjacent tissues. Furthermore, it provides a stable environment for new bone replacement during the gradual degradation of the scaffold by cells, offering significant advantages for subsequent scaffold implantation, attracting cell migration, and inducing mineralization.

The present application relates to the field of bone tissue engineering materials, and relates to a synthetic bone repair material with a biomimetic structure.The present application prepares a nano wool protein / hydroxyapatite composite biomimetic bone material through an in-situ mineralization process, and the wool material is dissolved, purified, dialyzed and separated and purified to obtain a wool protein solution.The wool protein solution is mixed with a calcium ion solution, and a proper surfactant, a pH value regulator and a performance control substance are added to obtain a precursor solution.On this basis, the in-situ mineralization reaction is carried out by dropping the phosphate to obtain the nano wool protein / hydroxyapatite composite biomimetic bone material.The composite biomimetic bone material obtained by the in-situ mineralization deposition has high rigidity and toughness, can simulate the organic / inorganic components in human bones, and has good bone replacement performance.

This invention discloses a β-tricalcium phosphate-based photocurable ceramic slurry and its preparation method. By volume, it comprises the following components: 66-75 parts modified ceramic powder, 25-30 parts resin premix, and a dispersant comprising 10-20% of the modified ceramic powder by mass. The modified ceramic powder is KH560 or KH570 modified ceramic powder. The mass ratio of β-tricalcium phosphate, hydroxyapatite, and 3Y-TZP is 4-10:2-6:1. The average particle size of β-tricalcium phosphate is 6-12 μm and / or 1-4 µm; the average particle size of HA particles is 1-4 µm and / or 300-500 nm; and the average particle size of 3Y-TZP particles is 300-500 nm and / or 80-120 nm. While ensuring high solids content, high dispersion stability and good rheological properties, it can also achieve degreasing and sintering densification, effectively improve the mechanical stability of green bodies, optimize the density and mechanical properties of sintered bodies, and retain the good biocompatibility and bioactivity of β-TCP, thereby meeting the needs of high-standard medical applications such as bone repair and bone replacement.

The present invention relates to the field of bone replacement materials and bone scaffolds. In particular, the invention relates to a bone replacement material comprising:-at least one porous calcium silicate-coated particle comprising: a core which is a porous particle having microporosity and macroporosity; and made from at least one calcium phosphate-based compound; and a calcium silicate coating completely or partially embedding the core; the calcium silicate coating comprises 60% to 100% by weight of at least one calcium silicate compound based on the total weight of the calcium silicate coating; and optionally, at least one uncoated porous particle having microporosity and macroporosity and made of at least one calcium phosphate-based compound. The invention also relates to a bone scaffold resulting from hydration of a bone substitute material of the invention; and a method for manufacturing the bone replacement material.

The invention relates to the technical field of medical bone replacement, and particularly discloses a grinding head guide plate for arthroscopic single condylar arthroplasty, which comprises a base bottom plate, a mechanical arm is rotatably connected to the top of the base bottom plate, a support frame is rotatably connected to one end, far away from the base bottom plate, of the mechanical arm, a grinding head bottom plate is fixedly connected to the top of the support frame, and a grinding head is fixedly connected to the grinding head bottom plate. A grinding head guide plate is slidably connected to the top of the grinding head bottom plate, the grinding head guide plate can adapt to different bone types of different people, it is not needed to find the proper bone type after multiple times of comparison, meanwhile, when a doctor conducts grinding, the doctor can well know the grinding distance to achieve more accurate grinding, and the grinding efficiency is improved. Meanwhile, the grinding angle can be well controlled and adjusted through the grinding head guide plate, so that precise control is achieved. According to the grinding head guide plate for arthroscopic single condylar arthroplasty, the purpose of improving the success rate of an operation and the grinding accuracy is achieved.

This invention belongs to the field of bone replacement material technology, specifically relating to a porous biodegradable bone replacement scaffold and its preparation method. The porous biodegradable scaffold of this invention consists of pillars, each pillar having an outer shell and a core. The outer shell comprises ZnO, and the core comprises Zn. The porous biodegradable bone replacement scaffold of this invention has a nano- to millimeter-level hierarchical pore structure, which is more similar to the structure of human bone. Furthermore, its degradation performance, antibacterial properties, and biocompatibility are superior to existing biodegradable metallic bone implant materials (zinc and its alloys), which helps promote osteogenic differentiation.

This application relates to the field of medical devices, and more particularly to a 3D-printed personalized subtotal femoral replacement prosthesis, comprising a 3D-printed femoral segment. One end of the 3D-printed femoral segment has a short medullary nail integrally formed therein, which is inserted into the remaining femoral medullary cavity after osteotomy. The end of the 3D-printed femoral segment away from the short medullary nail is connected to the proximal femur, which is used to connect to the femoral head prosthesis. A reinforcing screw is inserted within the 3D-printed femoral segment, coaxially arranged with the 3D-printed femoral segment, and is used to sequentially penetrate from the distal end of the remaining femur into the short medullary nail and the 3D-printed femoral segment. This application has the effect of improving the stability of the femoral replacement prosthesis.

The invention relates to the technical field of medical instruments, and discloses an orthopedic joint osteotomy replacement instrument and an auxiliary system thereof. When the adjusting frame and the hoisting binding belt are turned over along the hinged part and the height and the hoisting angle of the hoisting binding belt are further adjusted to be matched with the bending degree of the bone joint of a patient, the adjusting plates on the two sides of the adjusting frame can slide outwards in the positioning plates, the circular guide blocks at the ends of the adjusting plates can slide in the ratchet bars through the connecting blocks, and at the moment, the adjusting frame is fixed; the rotating block can rotate in a reciprocating mode under abutting fit of the elastic clamping hook, so that the circular guide block can jump to a certain position along the ratchet bar to be clamped by the ratchet groove, and a triangular stable structure is formed among the positioning plate, the adjusting plate, the side edge of the adjusting frame and the transverse plate. In this way, fine adjustment of the supporting height and angle of the ribbon hoisted on the adjusting frame is achieved, the ribbon is fixed at the same time, and further bending osteotomy operation adjustment of bone joints is more convenient.

Provided is a total talar replacement prosthesis that has a metallic body shell and a metallic or biologic core, where the metallic body shell includes one or both of a removable calcaneus attachment and a removable navicular attachment. The attachments, when removed, exposes a respective calcaneus-facing surface or a navicular-facing surface that can enhance fusion to the respective bones, calcaneus and / or navicular.