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Dicalcium silicate coating layer-titanium alloy loading bone replacement material and its preparation method

A replacement material, dicalcium silicate technology, applied in medical science, prosthesis, etc., can solve the problems of unsatisfactory comprehensive mechanical properties, limited application, low fracture toughness, etc.

Inactive Publication Date: 2002-11-20
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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Problems solved by technology

The reason may be the same as other ceramic materials, because of its unsatisfactory comprehensive mechanical properties, especially low fracture toughness, which limits its application in bearing bone replacement materials
D. Lamy et al. only used dicalcium silicate as the binding layer of plasma sprayed hydroxyapatite coating to improve the bonding strength of plasma sprayed hydroxyapatite coating, but did not conduct research on the biological activity and compatibility of the material and characterization (D. Lamy, A.C. Pierrc and R.B. Heimann. Hydroxyapatite coatings with a bond coat of biomedical implants by plasma projection. J. Mater. Res. 1996; 11: 680-686.)

Method used

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  • Dicalcium silicate coating layer-titanium alloy loading bone replacement material and its preparation method
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  • Dicalcium silicate coating layer-titanium alloy loading bone replacement material and its preparation method

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Embodiment

[0020] Chemically pure CaCO 3 and SiO 2 According to the molar ratio of 2:1 ingredients, ball milling and mixing in water medium for 12 hours, after drying, put it into a corundum crucible, keep it at 1440°C for 2 hours, and use solid phase synthesis reaction to prepare γ-Ca 2 SiO 4 Particles, whose particle size ranges from 5 to 30 μm. Using atmospheric plasma spraying technology, using the spraying parameters in Table 2, the γ-Ca 2 SiO 4 Powders were deposited on cleaned and blasted Ti-6Al-4V substrates. After spraying, the main crystal phase of dicalcium silicate coating is β-Ca 2 SiO 4 , while a glassy phase exists (see figure 1 ). The bonding strength of the coating measured by ASTM 633-79 method is about 39MPa. Simulated body fluid immersion experiments show that hydroxyapatite containing carbonate groups can be formed on the surface of dicalcium silicate coating within one day (see figure 2 and image 3 ). Mouse embryonic osteoblast culture experiments show...

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Abstract

The present invention relates to a bone substituted material. Said bone substitute material is dicalcium silicate coating layer deposited on the surface of titanium alloy of Ti-6Al-4V, said coating layer is formed from beta-Ca2SiO4 and glass phase, and its thickness if 50-400 micrometers. Its preparation method incldues the following steps: firstly, synthesizing gamma-Ca2SiO4, then using atmospheric plasma spraying process to deposit the dicalcium silicate coating layer on the titanium alloy base body, and the combination strength of said coating layer and base body is greater than 34-40 MPa.The tests show that the bone apatite can be formed on the surface of dicalcium silicate, and cell can quickly grow and proliferate on the beta-Ca2SiO4 coating layer surface, so that said substitute material possesses good biological activity and compatibility.

Description

technical field [0001] The invention relates to a new bone replacement material and a preparation method thereof, more precisely, relates to the preparation of a dicalcium silicate bioactive coating—a titanium alloy bearing bone replacement material—by a plasma spraying method, and belongs to the field of medical bioceramic coatings. Background technique [0002] The use of plasma spraying technology to spray bioactive ceramics on titanium alloy substrates is one of the most commonly used methods to prepare bone-bearing bone replacement materials with excellent mechanical properties, good bioactivity and biocompatibility. However, the application of commonly used bioactive ceramics (such as hydroxyapatite and bioglass) coatings is weakly bonded to the titanium alloy substrate, which limits their application. Although people use various measures to improve it, such as composite coating and gradient coating techniques and methods, they have not achieved satisfactory results. ...

Claims

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Application Information

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IPC IPC(8): A61L27/02A61L27/04
Inventor 刘宣勇郑学斌陶顺衍丁传贤
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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