23 results about "Bone substitute" patented technology

The invention discloses a body temperature responsive wet adhesive as well as a preparation method and application thereof in bone defect repair, and belongs to the technical field of preparation of bone defect repair materials. Carbon-carbon double bonds in methoxyethyl acrylate (MEA), N-isopropylacrylamide (NIP) and acrylic acid (AA) are subjected to a free radical polymerization reaction to generate a polymer chain, and a cross-linking agent containing metal cations is added for cross-linking. The body temperature responsive wet adhesive has a good wet adhesion effect and the ability of improving the stability of bone meal, and can solve the technical problem of bone substitute displacement caused by unstable fixation of a barrier membrane.

A bone substitute composition includes a bone substitute matrix and a conditioning solution. The bone substitute matrix includes 85% to 98% by weight of alkaline calcium phosphate powder, 1% to 10% by weight of a polymer, and 1% to 5% by weight of a crosslinker. The conditioning solution includes 90% to 97% by weight of water, 1% to 5% by weight of a phosphate, and 1% to 5% by weight of a water-soluble acidic compound.

A system for performing interbody fusion surgery including an expandable intervertebral spacer and specialized instruments for choosing the correct size of implant, implanting the device within the intervertebral space, and for delivery of bone graft or bone substitute to the interior of the implant.

The present invention relates to composite particles for 3D printing, which are made into pellets by hot melt extrusion of: 50 to 90 wt% of at least one polymer based on polycaprolactone; 10% to 50% by weight of at least one filler; and optionally up to 5% by weight of at least one additive, the total weight of the components being 100% by weight, and subsequently grinding the pellets to obtain the composite particles. Furthermore, the invention relates to a composition for 3D printing, comprising a) 94 to 99 wt% of at least one composite particle according to the invention; b) 1% to 6% by weight of at least one filler; and c) optionally up to 5% by weight of at least one additive, wherein the total weight of a) to c) is 100% by weight. Furthermore, the invention relates to a 3D printing process comprising the composite particles or composition according to the invention, an article obtained by said 3D printing process, and the use of the article as a bone substitute or a scaffold for fracture repair.

This utility model discloses a skull base defect repair device with adjustable function, including a card body. The front side of the card body is convex, and the rear side is concave. A clamping part is provided at the center of the front side of the convex side. The clamping part is arranged in an "I" shape. With the card body and clamping part provided, compared with other rigid reconstruction materials, this invention uses β-tricalcium phosphate material that can absorb human bone. It is made by mechanical processing or 3D printing technology. It has good biodegradability, biocompatibility, and non-toxicity. It can be used as an ideal bone substitute material for rigid reconstruction. In addition, this application also has the advantages of being ultra-thin, having stable clamping and good sealing effect, which can greatly reduce the occurrence of complications such as rejection reaction, postoperative cerebrospinal fluid leakage, postoperative brain tissue protrusion, and intracranial infection.

The invention relates to a biphase calcium phosphate / hydroxyapatite bone substitute material and a preparation method thereof. The bone substitute material comprises a degradable calcium phosphate core layer, a porous hydroxyapatite precursor layer and a hydroxyapatite gradient layer, wherein the porous hydroxyapatite precursor layer is formed on the surface of the degradable calcium phosphate core layer in situ through a sol-gel method, and the hydroxyapatite gradient layer is formed through electro-deposition treatment and covers the porous hydroxyapatite precursor layer. According to the technical scheme, a layered mineralization structure with a porous hydroxyapatite precursor layer as a template is constructed, and a hydroxyapatite layer with a continuous gradient in the thickness direction is formed through segmented electro-deposition treatment, so that the obtained composite material realizes continuous transition from outside to inside in the aspects of porosity, grain size, crystallinity and Ca / P ratio. The structure of the biphase calcium phosphate / hydroxyapatite bone substitute material can remarkably improve the interface bonding strength, the ion exchange capacity and the biological activity, so that the osteoblast adhesion, proliferation and osteogenic differentiation capacities are improved, and the overall osteogenic performance is obviously superior to that of an existing material.

The present invention discloses a method for preparing an antibacterial porous titanium-nickel alloy and its products, comprising the following steps: 1) batching: titanium powder, nickel powder, copper agent, selenium agent and pore-forming agent are weighed according to the designed ratio; 2) mixing: the weighed raw materials are mixed in two steps to obtain a uniform mixed powder; 3) green compacting: the uniform mixed powder is pressed to obtain a green compact; 4) sintering: the green compact is placed in a high-temperature sintering furnace and sintered in a hydrogen + argon mixed atmosphere. After sintering, the green compact is cooled to room temperature with the furnace to obtain an antibacterial porous titanium-nickel alloy. The present invention gives full play to the synergistic antibacterial effect of copper and selenium, combines the pore-forming agent and the sintering process to regulate the pore structure, and prepares a porous titanium-nickel alloy with excellent and long-term antibacterial properties and an elastic modulus that matches human bone. The production process of the present invention is simple and easy to implement, has low production cost, is suitable for mass production, and has good prospects for application in various medical bone substitute materials.

The utility model discloses a kind of morphology detection devices of calcium phosphate bone material in the technical field of bone substitute material detection, including rack, scanning electron microscope, holder, control unit and the flexible detection platform for fixedly placing calcium phosphate bone material, flexible detection platform includes the upper clamping piece and lower clamping piece of vertical spacing adjustable, upper clamping piece includes several longitudinal pressure ropes, lower clamping piece includes several horizontal pressure ropes, longitudinal pressure rope and horizontal pressure rope are used to adapt to the outer contour of different morphologies of calcium phosphate bone material by tensile deformation to hold calcium phosphate bone material.The utility model provides the morphology detection device of calcium phosphate bone material, through the cooperation of longitudinal pressure rope and horizontal pressure rope, the effect of stably clamping different sizes and different outer contour structures of calcium phosphate bone material is realized, and the convenience and detection effect of morphology detection to calcium phosphate bone material are improved.

The present disclosure relates to a porous composite material, and more specifically to a porous composite material that is capable of manufacturing a porous composite material having a pore size that exhibits excellent bone regeneration ability, 5 while also having excellent compressive strength, clastic modulus and shape recovery properties, a manufacturing method thereof and a bone graft material using the same.

The invention provides an antibacterial nickel-titanium alloy bone tissue engineering scaffold as well as a preparation method and application thereof. The preparation method comprises the following steps: polishing a nickel-titanium alloy sheet; carrying out acid etching treatment on the nickel-titanium alloy sheet subjected to the polishing treatment; then adopting glutaraldehyde crosslinking to introduce a chitosan coating; and introducing a sodium alginate coating and a chitosan quaternary ammonium salt coating to prepare the antibacterial nickel-titanium alloy bone tissue engineering scaffold. According to the antibacterial nickel-titanium alloy bone tissue engineering scaffold, the chitosan quaternary ammonium salt coating is formed on the surface of the nickel-titanium alloy in a layer-by-layer self-assembly mode, the tissue compatibility of the nickel-titanium alloy can be effectively improved, the antibacterial activity is good, the osteogenic activity of osteoblasts can be enhanced, proliferation of the osteoblasts is facilitated, and the bone tissue engineering scaffold has a good application prospect. And the material can be widely applied to bone substitute materials.

In the present invention, stem cells are induced to differentiate into osteoblasts by three-dimensional culturing and cell masses are formed to produce a bone substitute. By employing lyophilization, it is possible to reduce the risk of tumor formation and, additionally, to control immunogenicity and local inflammation. By optimizing the temperature and time of an initial freezing step, a primary drying step, and a secondary drying step, it is possible to provide a bone substitute achieving good performance and having reduced cost. It is possible to provide a bone substitute having high safety and higher osteoconductivity and osteoinductivity.

In the present invention, stem cells are induced to differentiate into osteoblasts by three-dimensional culturing and cell masses are formed to produce a bone substitute. By employing lyophilization, it is possible to reduce the risk of tumor formation and, additionally, to control immunogenicity and local inflammation. By optimizing the temperature and time of an initial freezing step, a primary drying step, and a secondary drying step, it is possible to provide a bone substitute achieving good performance and having reduced cost. It is possible to provide a bone substitute having high safety and higher osteoconductivity and osteoinductivity.

A bone implant (1), a method for manufacturing a bone implant (1), and a computer program product are described. The bone implant has a cuff (2) that surrounds an interior space (7) at least partially, and an electrode arrangement (3) that is arranged at least partially on an inner surface (10) of the cuff (2) facing the interior space (7), wherein the interior space (7) is suitable for receiving a bone substitute material (6) to establish an electrically conductive connection with the electrode arrangement (3).The described technical solution is characterized by the fact that the cuff (2) is manufactured using an additive manufacturing process based on data containing patient-specific information, can be attached to the bone (9) surrounding the defect (8), and that the electrode arrangement (3) can be supplied with electrical energy to introduce an electric current into the bone substitute material (8) arranged in the interior (7) by means of a stimulation unit (5) and an electrical energy storage device (11) which are at least indirectly attached to the cuff (2).

The invention provides a plasma matrix bone block and a preparation method and application thereof, and belongs to the technical field of biomedical materials. The preparation method comprises the following steps: obtaining a liquid plasma matrix and a buffy coat, placing the liquid plasma matrix and the buffy coat together with bone substitute material particles in a solid plasma matrix blood collection tube, carrying out rotary oscillation, and solidifying to obtain a plasma matrix bone block precursor; the plasma matrix bone block precursor is placed in a mold, a pressurizing gasket is placed at a sample inlet of the mold, the plasma matrix bone block precursor is compressed and shaped through centrifugation, and the plasma matrix bone block is obtained. Compared with a traditional plasma matrix bone block, the plasma matrix bone block provided by the invention is higher in mechanical strength and slower in degradation rate, and has more advantages in the aspect of promoting bone defect repair; and the preparation method is simple and has strong repeatability.

Materials for additive manufacturing. More precisely, a non-breaking filament, preferably for 3D printing bone substitutes. The filament includes 50% to 99% in weight to the total weight of the filament (w / w) of a polymeric matrix and 1% to 50% w / w of tricalcium silicate. Also, a method and composition for preparing the filament. Additionally, the uses of the filament, such as for example in the dental field; especially, for providing suitable bone and dental substitutes.

"POROUS BONE SUBSTITUTION MATERIAL" The present invention relates to a porous bone substitute material intended for bone repair, in particular the repair of a cavity bone defect and / or the repair of a segmental bone defect.

The present invention relates to the field of bone replacement materials and bone scaffolds. In particular, the invention relates to a bone replacement material comprising:-at least one porous calcium silicate-coated particle comprising: a core which is a porous particle having microporosity and macroporosity; and made from at least one calcium phosphate-based compound; and a calcium silicate coating completely or partially embedding the core; the calcium silicate coating comprises 60% to 100% by weight of at least one calcium silicate compound based on the total weight of the calcium silicate coating; and optionally, at least one uncoated porous particle having microporosity and macroporosity and made of at least one calcium phosphate-based compound. The invention also relates to a bone scaffold resulting from hydration of a bone substitute material of the invention; and a method for manufacturing the bone replacement material.

The invention relates to a preparation method of an artificial keel. The preparation method comprises the following steps: S101, treating an animal skeleton to prepare porous ossein; s102, carrying out reaction on the porous ossein and mineralizing liquid to obtain mineralized ossein; s103, further reacting the mineralized ossein with the deposition liquid to obtain calcified ossein; s104, fully and uniformly mixing the calcified ossein and the kaolin / montmorillonite wrapping slurry, and performing compression molding; and S105, the bone collagen obtained after compression molding is put into a muffle furnace to be dried, carbonized and calcined at the high temperature and subjected to damp-heat curing, and finally the artificial keel is prepared. The artificial keel mineral medicinal material which is very similar to natural keel in component, structure and effect and has great advantages is prepared, and a large number of natural keel substitutes which are controllable in quality, safe, effective and relatively low in cost can be continuously provided for the market by utilizing existing rich resources; the scarcity of the medicinal material market is made up.

An apparatus for maxillary sinus mucosa dissection and elevation, in humans or in animals, that lifts said mucosa away from the maxillary bone by injecting a fluid through an osteotomy or a hole in the maxillary bone to create an artificial space between said mucosa and the maxilla, that artificial space is to be subsequently filled with bone substitute or a dental implant or both, this apparatus is used in a new method to determine intra operatively whether the sinus mucosa is successfully lifted, along with the height of the lift, or if it has been perforated.

The utility model discloses a device for preparing a viscous bone, particularly relates to the technical field of medical instruments, and aims to solve the problems of tedious manual operation, long time and the like in the preparation of the viscous bone in the prior art, the device comprises a rod part, the rod part comprises a first rod part and a second rod part, the top of the first rod part is connected with a removing part, and the top of the second rod part is connected with the removing part. The tail part of the removing part is connected with the upper part of the filter, the removing part is used for removing the particle biological material mixed with the platelet aggregate, and the filter is used for filtering red blood cells in the blood while retaining the particle bone substitutes; the top of the second rod part is connected with the lower part of the filter, and the tail of the second rod part is connected with a supporting part which is in contact with the bottom of a test tube for supporting. According to the utility model, the combination of the granular bone substitute material and the platelet concentrate can be generated without manual operation in the mixing step.

This invention belongs to the field of bone replacement material technology, specifically relating to a porous biodegradable bone replacement scaffold and its preparation method. The porous biodegradable scaffold of this invention consists of pillars, each pillar having an outer shell and a core. The outer shell comprises ZnO, and the core comprises Zn. The porous biodegradable bone replacement scaffold of this invention has a nano- to millimeter-level hierarchical pore structure, which is more similar to the structure of human bone. Furthermore, its degradation performance, antibacterial properties, and biocompatibility are superior to existing biodegradable metallic bone implant materials (zinc and its alloys), which helps promote osteogenic differentiation.

The invention discloses a plasma matrix bone block preparation assembly, a mold production method and a plasma matrix bone block preparation method, the plasma matrix bone block preparation assembly comprises a first mold, a first groove is formed in the first mold, the inner surface roughness Rsm of the first groove is larger than or equal to 0.1 mu m and smaller than or equal to 0.2 mu m, and the first mold is a titanium part. The plasma matrix bone block preparation assembly provided by the invention can promote the formation of a fibrous protein network, accelerate the gel formation speed of the plasma matrix, enhance the cross-linking tightness of the plasma matrix and a bone substitute material, shorten the preparation time of the plasma matrix bone block, and improve the preparation efficiency and mechanical strength of the plasma matrix bone block; the clinical application scene of the plasma matrix bone block is expanded.

The present disclosure provides a biocompatible polymer and composition having antibacterial and osteogenic properties to promote periodontal tissue regeneration. The polymer is a polyxylitol succinate (PXS) polymer prepared by esterifying xylitol with succinyl chloride. Adhesive properties were subsequently incorporated into the polymer by combining biocompatible catechol via caffeic acid (CFA) in the presence of citric acid. The final injectable caffeic acid / PXS / citric acid composite polymer (iCPC) hydrogel was fabricated by cross-linking the pre-polymer solution with MgO. PXS and iCPC polymers have anti-bacterial effects and osteogenic properties. The disclosure further provides uses of the polymer such as tissue engineering, drug delivery, as a bioadhesive in wound healing, as bone substitutes or scaffolds, as cements in dental and periodontal applications and as anti-adhesives or protective barriers.