57 results about "Bioadhesive" patented technology

The invention belongs to the technical field of biological materials and ultrasonic printing, and particularly discloses a biological adhesive for ultrasonic printing and preparation and application thereof. The biological adhesive comprises a heat-sensitive main body material and a chemical adhesion component, the heat-sensitive main body material comprises hydroxybutyl chitosan, and the chemical adhesion component comprises polyacrylic acid-N-hydroxysuccinimide ester. The bioadhesive has excellent ultrasonic responsiveness, formability and bioadhesion performance, directional deposition, in-situ solidification and tissue surface adhesion can be achieved in a non-contact and accurately-controlled ultrasonic printing system, and the bioadhesive is suitable for various biomedical scenes such as tissue repair, minimally invasive medicine, biological device construction and drug delivery interface printing.

There is provided a hemostatic bioadhesive including from 0.5 to 5 w / v % of chitosan or alginate measured as a weight percent of chitosan or alginate with respect to a total dry volume of the hemostatic bioadhesive, the chitosan or alginate being crosslinked and forming a first polymer network; from 0.5 to 13 w / v % of polyacrylamide or polyethylene glycol measured as a weight percent of polyacrylamide or polyethylene glycol with respect to the total dry volume of the hemostatic bioadhesive, the polyacrylamide or polyethylene glycol being crosslinked and forming a second polymer network, wherein the first polymer network and the second polymer network form a dissipative polymer matrix; and from 0 to 100 v / v % of an adhesive liquid infused in the dissipative polymer network. The hemostatic bioadhesives comprise interconnected pores in the dissipative polymer matrix having a size of 20 to 400 μm.

An antithrombotic surface-modified biomaterial is provided comprising a biomaterial substrate coated with a polymerizable dopamine-containing bioadhesive to which is attached one or more antithrombotic agents. A method of preparing the surface-modified biomaterial is also provided. The surface-modified biomaterial is beneficial for use in blood-contacting medical devices such as catheters, dialyzers and blood oxygenators to prevent or minimize the occurrence of thrombosis on the surface thereof.

The invention discloses an adhesive compound with an adhesive property optimized based on metal hydroxides as well as a preparation method and application of the adhesive compound, and belongs to the technical field of biological adhesives. The present invention relates to an adhesive composition comprising an adhesive precursor consisting of a protein-polyphenol composite hydrogel and a hydrogen bond destructive small molecule compound capable of network reconstitution comprising beta-folding formation in aqueous phase grafting comprising a metal hydroxide having the characteristics of: (a) a hydration enthalpy value of from-1000 kJ / mol to-4000 kJ / mol; (b) a dissociation constant of from 6 pKa to 13.5 pKa; (c) a water exchange rate of 105 S <-1 > to 10 < 10 > S <-1 >. The adhesion compound can be networked to form an advanced structure when encountering water, not only can generate underwater lap joint shear strength of more than 1MPa, but also can tolerate underwater long-term soaking and temperature change from-196 DEG C to 100 DEG C, and meanwhile, the adhesion compound also has good biocompatibility, can meet the requirement of the environment in a human body on tissue adhesion safety, and has good application prospects. Stability suitable for in vivo tissue repair and industrial applications is exhibited.

The invention belongs to the technical field of organic-inorganic compounding, and aims to solve the problem of treatment of temporomandibular joint osteoarthritis (TMJOA). Magnesium-gallic acid metal organic framework (Mg-GA MOF) particles are synthesized through a hydrothermal method, hyaluronic acid is subjected to hydroformylation and double-bond modification to obtain OHAMA, and the magnesium-gallic acid metal organic framework (Mg-GA MOF) particles and the OHAMA particles are compounded to prepare the MOF-Gel composite hydrogel. The hydrogel is injectable and high in tissue retention rate, has dual effects of inhibiting pyroptosis and promoting regeneration on condylar cartilage cells, can effectively promote cartilage repair, shows a good effect in TMJOA treatment, and has a wide application prospect.

A film and a method for use thereof such as for the administration of a biologically active agent or for therapy are provided. Specifically, a film, composed of a biodegradable material having a mucoadhesive surface comprising a plurality of mushroom-type structures is provided.

A patch to be placed over an injury or defect in tissue in a biological structure having a lumen and preventing migration of contents of the biological structure through the injury or the defect. The patch includes an adhesive layer configured to adhere to the biological tissue via formation of hydrogen or covalent bonds with chemical groups present in the biological tissue and a backing layer coupled to and coextensive with the adhesive layer, the backing layer configured to be impervious to the contents.

The present application relates to the technical field of biological adhesives, and particularly relates to a human tissue adhesive and a preparation method thereof, which comprises the following raw materials: modified polydopamine nanoparticles, sulfonated carbon nanotubes, selenium-calcium phosphate composite nanoparticles (Se-HAp NPs), growth factors, curcumin, quercetin, poly (N-isopropyl acrylamide) and polylactic acid. In the present application, the modified polydopamine nanoparticles significantly improve the wet-state adhesive strength of the adhesive, and the flexible nano-supporting effect of the sulfonated carbon nanotubes synergistically enhances the adhesion and flexibility thereof, and the two form a stable nano-network structure to support the uniform distribution of the Se-HAp NPs, the sulfonated carbon nanotubes ensure the functional integrity of the Se-HAp NPs in a dynamic environment, and the Se-HAp NPs together with the modified polydopamine nanoparticles improve the biological activity and stability of the adhesive, and promote tissue repair, so that the adhesive can adapt to a dynamic tissue environment.

The invention relates to a composite material element (20), in particular for the manufacture of a glider as well as other boats and boat components. The composite material element (20) is characterized in that it has at least one inherently flame-retardant layer (22) of a cork material (24) and a biogenic binder (26). Furthermore, the invention relates to a method for manufacturing such a composite material element (20) and a slider (34) comprising composite material elements (20).

The present invention provides a hemostatic composite sponge comprising oxidized cellulose and an essentially gelatin-free bioadhesive material stably associated with said sponge and present in an organized pattern on said sponge.

The invention discloses a stem cell microcapsule-entrapped tissue adhesive, a preparation method and application, the tissue adhesive is composed of stem cell microcapsule-entrapped hydrogel and a biological adhesive, and live stem cells are entrapped in the tissue adhesive; the stem cells are selected from at least one of umbilical cord mesenchymal stem cells, bone marrow mesenchymal stem cells, adipose-derived stem cells, embryonic stem cells and induced pluripotent stem cells; the biological adhesive is formed by compounding a hydrophilic polymer and a block polymer, wherein the mass ratio of the hydrophilic polymer to the block polymer is (1: 5)-(5: 1); the transmittance of the tissue adhesive is 60-100%, the tissue adhesive strength is 20-200 kPa, and the volume swelling ratio is smaller than or equal to 50%. According to the scheme, the stem cell entrapped microcapsule and the biological adhesive are mixed to prepare the tissue adhesive, and the adhesive can be used as bio-ink to be assembled into a bionic scaffold through 3D printing or directly injected to an injured part, so that the tissue adhesive has a wide application prospect.

The invention discloses a dry and wet dual-purpose biological adhesive and a preparation method thereof.The preparation method comprises the steps that a polypeptide aqueous solution and a polyethylene glycol dimaleimide aqueous solution are mixed, the pH is adjusted to 7-8, and R-liquid is obtained; and mixing the R-liquid with a chelating agent, and drying to obtain the dry and wet dual-purpose biological adhesive. The designed Switch polypeptide can be complexed with Zn ions, after the Zn ions are introduced into R-liquid, the Switch polypeptide is subjected to conformation transformation from a random coil mode to a spiral coil coiling mode, and the change caused by the conformation transformation is mainly reflected in that hydrophilic and hydrophobic amino acids of the polypeptide can be spatially rearranged according to the spiral coil coiling rule; hydrophilic amino acids are completely exposed on the outer side, hydrophobic amino acids are orderly arranged on the inner side, hydrophobic side chains are also completely stretched, the hydrophobic amino acid side chains complete high-strength adhesion of polypeptide and an interface, and the biological adhesive achieves the adhesion effect according to the principle.

The invention provides multifunctional bioadhesive hydrogel as well as a preparation method and application thereof, and relates to the technical field of biomedical materials. The preparation method comprises the following steps: dissolving dopamine modified gelatin (DA-Gel), sulphobetaine methacrylate (SBMA), acrylic acid (AA) and perfluoroalkyl ethyl methacrylate (PFEMA) in a dimethyl sulfoxide (DMSO) solution, uniformly stirring, injecting into a mold, carrying out cross-linking polymerization by adopting electron beam radiation without adding a chemical cross-linking agent, and preparing a hydrophobic film by adjusting the radiation absorption dose (0-50 kGy) and the hydrophobic monomer content. The mechanical property, the adhesion strength and the swelling behavior of the hydrogel can be accurately regulated and controlled, and the hydrogel with a three-dimensional interpenetrating network structure is obtained. The hydrogel prepared by the process can form rapid and tough adhesion on the surface of a moist tissue, effectively seal a wound, resist swelling in a body fluid environment and promote tissue regeneration, and has a wide clinical application prospect in the fields of wound hemostasis, surgical incision closure, viscera perforation repair and the like.

The present disclosure relates to an adhesive elastin and suckerin-based multiblock copolypeptide with stimulus responsiveness and surface adhesion, a self-assembled structure thereof, and application of an injectable hydrogel as a bioadhesive.

The present invention relates to a biocompatible, tissue adhesive, chitosan flowable dressing, optionally modified with catechol, and suitable for treating bleeding in a physiological environment, e.g., gastrointestinal tract, bladder (in particular in connection with the TURP procedure). The characteristics and structures of the chitosan dressing are provided. Methods of making and using the chitosan dressing are also provided.

The application belongs to the field of medicine and health technology, and particularly relates to preparation and application of a novel bioadhesive with high biological adhesion and high biological compatibility for promoting peripheral nerve injury repair, which comprises the following steps: (1) grafting acetylcysteine and dopamine on chitosan to prepare modified chitosan gel with self-crosslinking performance as an adhesive layer; (2) preparing sodium alginate and polyacrylamide covalent / non-covalent double crosslinked gel with high strength and toughness as a substrate layer; and (3) uniformly coating the adhesive layer on the substrate layer, and cutting the adhesive layer into blocks of different sizes according to the requirements of use, so that the novel bioadhesive with high biological adhesion and high biological compatibility for promoting peripheral nerve injury repair is obtained.

Among the various aspects of the present disclosure is the provision of a biological adhesive and methods of use thereof. A biological adhesive is described that limits complications from anastomotic leaks and provides a faster, simpler, and safer solution over the use of sutures. Methods of using the biological adhesive in single and double-layer tape form are also described.

A composition of matter useful as a bioadhesive including a bistable adhesive polymer. The bistable adhesive polymer includes one or more polymer backbones; side-chains attached to each of the polymer backbones; and one or more transition temperatures between a crystalline state and an amorphous state. The one or more transition temperatures are such that the polymer transitions from the crystalline state to the amorphous state upon physical contact with biological tissue having a temperature higher than the transition temperature. The polymer adheres or attaches to the biological tissue in the amorphous state and can be peeled from the biological tissue when cooled below the transition temperature to the crystalline state.

The invention discloses a lipoic acid eutectic adhesive which is prepared by the following steps: preparing small molecules of a lipoic acid hydroxyl derivative; the invention further discloses a preparation method of the lipoic acid eutectic adhesive. The preparation method is used for preparing the lipoic acid eutectic adhesive. According to the eutectic adhesive disclosed by the invention, the derivative small molecules and the lipoic acid are mixed according to a certain proportion, and a eutectic system is constructed under a solvent-free condition, so that the eutectic adhesive is in a molten state at room temperature, and meanwhile, the use of an organic solvent is also avoided, and the safety of a product is greatly improved; the eutecticevaporate adhesive provided by the invention has very remarkable responsiveness to ultraviolet light; the dithiolane ring-opening polymerization reaction can be effectively triggered through short irradiation of ultraviolet light so as to cure the adhesive, high and reliable adhesive strength and eutectic adhesive are achieved, the production process is simple, timely and effective, the service life is long, and the dithiolane ring-opening polymerization adhesive has a good application prospect in the fields of biological adhesives and industrial adhesives.

The invention relates to the technical field of hydrogel biological adhesives, in particular to a fluorinated polypropyleneimine graft modified hydrogel biological adhesive and a preparation method thereof. The problems existing in the prior art are as follows: a conventional hydrogel biological adhesive is easily influenced by a hydration layer on the surface of a biological tissue, so that close contact and interaction between adhesive molecules and the tissue are weak, and the wet adhesion strength is poor. Aiming at the technical problems, the invention provides the fluorinated polypropylene imine grafted modified hydrogel biological adhesive which is a hydrogel biological adhesive formed by carrying out physical cross-linking reaction and covalent cross-linking reaction on lipoic acid, polyethyleneimine and fluorinated polypropylene imine in an alkaline aqueous solution, and the structure of the hydrogel biological adhesive is formed by introducing a fluorinated group into F-PPI. The introduction of fluorinated groups can effectively repel a hydration layer on the surface of a biological tissue and promote close contact between adhesive molecules and a tissue interface, so that the problem of weak adhesive force of conventional hydrogel in a humid environment is solved.

The application belongs to the technical field of biomedical materials, and particularly relates to a biological adhesive with stable performance and a preparation method and application thereof. Specifically, by regulating a mixing mode of active ester and amino cross-linking agent, using an acidic polylysine hydrochloride aqueous solution as the amino cross-linking agent, directly dissolving the active ester in the polylysine hydrochloride aqueous solution, the solution mixing system formed has stable performance, can be stored at room temperature for 6 hours, an operator can prepare before operation, and can be used at any time during operation, and has good batch stability, avoids individual differences, and therefore has important application value and market prospect.

Disclosed herein are citrate-based mussel-inspired bioadhesives and methods of making and using the same. Also disclosed herein are methods of treating wounds.

The invention discloses an acid-resistant anti-swelling hydrogel biological adhesive as well as a preparation method and application thereof. The preparation method comprises the following steps: forming a uniform mixed solution from a carboxyl monomer, polymerizable cyclic lactam, zwitter-ions, a cross-linking agent and an initiator under magnetic stirring; adding the mixed solution into a polytetrafluoroethylene mold, isolating oxygen by using a glass sheet, and irradiating and curing under an ultraviolet lamp to obtain hydrogel; the hydrogel is placed in deionized water to be soaked for 24 hours, then constant-weight treatment is conducted, and the hydrogel is obtained after the constant-weight treatment is finished. The biological tissue adhesive prepared by a one-step method can effectively resist strong acidity and acid corrosion, has good adhesion stability in a water environment, and has strong adhesion, good tissue compliance and matched mechanical properties and biological safety on a wet interface. Meanwhile, the hydrogel has excellent mechanical property and self-repairing property, and particularly has wide biological application prospect in biological tissue repair in extreme environments such as gastric perforation repair.

A class of biodegradable, surface-eroding cyclic poly(methacrylic anhydride) (PMAA) polymer-based biomaterials that are useful as bone cement or bio-adhesives. The synthesis of the biomaterials involves the preparation of linear cyclic PMAA prepolymers. The biomaterials may be further processed to make bone cement for orthopedic applications. Extensive testing of the biomaterials has confirmed that they are biodegradable, have a peak exotherm that is below 45° C., have no or negligible shrinkage, and have good mechanical properties. The biomaterials therefore provide advantages over commercial poly(methyl methacrylate) (PMMA) based bone cements that are currently used in medical applications ranging from dentistry to orthopedics.

Systems and methods are provided for on-person wearable electronic devices configured for extended periods of wear. A couplant may be provided that is made of a soft anti-dehydrating, and hydrogel-elastomer hybrid material. A bioadhesive may connect the couplant the electronic devices and the person. The couplant may serve as a coupling and transmission for information to or from the electronic device.

The invention discloses a dual crosslinking mechanical self-adaptive biological adhesion hydrogel. The mechanical self-adaptive biological adhesion hydrogel is prepared from dopamine modified sodium alginate, bovine serum albumin and multi-arm polyethylene glycol-phthalic dicarboxaldehyde through dual covalent crosslinking. The hydrogel is endowed with the mechanical self-adaptive characteristic through the combined action of dopa and protein. Under the stress action and physiological oxidation environment, protein conformation in the hydrogel is expanded and cooperates with gradual oxidation of dopa, so that stress dissipation and adhesion strength self-enhancement along with time are realized while the material keeps flexibility, and long-term effective sealing of tissues can still be maintained under the condition of dynamic deformation. The hydrogel has the characteristics of active oxygen removal, antibiosis and enzyme response degradability, the whole system is composed of biomacromolecules and medical macromolecules, and the hydrogel has good biocompatibility and in-vivo degradability. And a new technical approach is provided for the sealed repair of airway fistula, gastrointestinal fistula and other tissue defects and the development of implantable bioadhesive materials.

The invention belongs to the technical field of biomedical materials, and particularly relates to a composite hydrogel system for reducing blood sugar of diabetic wounds and removing blood sugar reducing byproducts and a preparation method of the composite hydrogel system. The composite hydrogel system comprises calcium carbonate, horse radish peroxidase and glucose oxidase which are encapsulated in a sodium alginate-hyaluronic acid dopamine matrix, and the composite hydrogel system is obtained. According to the composite hydrogel system, in a hyperglycemia wound microenvironment, gluconic acid and hydrogen peroxide which are generated by catalyzing decomposition of glucose are respectively used as substrates to drive a double-stage cross-linking reaction, and finally, the double-network hydrogel is formed. The in-situ formation of the hydrogel is driven by utilizing the by-product derived from the wound microenvironment, the biological adhesive can be obtained without adding an exogenous cross-linking agent while efficient local blood glucose reduction is realized, the potential toxicity of a traditional cross-linking agent can be avoided, and the biological adhesive has a good application prospect. A safe, efficient and self-regulation new scheme is provided for local treatment of diabetes wounds.

This invention discloses a method for preparing a composite nanofiber bone scaffold, belonging to the field of medical engineering technology. First, a bacterial cellulose (BC) membrane is prepared. BC membrane powder is then prepared by pre-cooling with liquid nitrogen and mechanical grinding, and subsequently dispersed in a polydopamine solution to obtain a BC polydopamine solution. The prepared decellularized submucosal layer (SIS) of the biological matrix membrane is incubated overnight in the BC polydopamine solution, and finally freeze-dried to obtain the composite nanofiber bone scaffold. This invention provides a method for preparing a composite bone scaffold using polydopamine, which has excellent film-forming properties and biocompatibility, does not hinder cell growth and differentiation, and combines BC and SIS in a green synthesis process with simple operation.

The utility model discloses an improved novel hemodialysis catheter which comprises a catheter body, a fixing device, a first blood outlet pipe, a second blood outlet pipe and a fixed connecting base, the first blood outlet pipe and the second blood outlet pipe are arranged on the fixed connecting base and communicated with one end of the catheter body, and the fixing device is arranged on the catheter body. The fixing device is provided with a sealing channel in a penetrating mode from the left end to the right end, the catheter body penetrates through the sealing channel and extends out of the left end and the right end of the fixing device, a sealing ring is arranged on a catheter body of the catheter body, and a biological adhesive binding face is arranged on the side, away from the fixing device, of the sealing ring. According to the hemodialysis catheter, the actual hemodialysis requirement is met, hemodialysis blood transportation is achieved, meanwhile, position deviation of the catheter body is eradicated, the stability of the catheter body is improved, and the situation that bacteria invade due to insertion of a hemodialysis catheter is eradicated.

The invention belongs to the technical field of biological adhesives, and provides a ball brush-aggregate composite biological adhesive as well as a preparation method and application of the ball brush-aggregate composite biological adhesive. A certain amount of nano spherical polyelectrolyte brush is added in the preparation process of a natural high-molecular polymer electrolyte composite coacervate to prepare the ball brush-coacervate composite biological adhesive. The natural high-molecular polymer electrolyte composite coacervate comprises a cationic natural high-molecular polymer and an anionic natural high-molecular polymer. Compared with a polyelectrolyte aggregate adhesive without ball brush doping, the ball brush-aggregate composite adhesive prepared by the invention shows higher adhesion strength and stability, and has a wide application prospect as a biological adhesive.