82 results about "Bioadhesive" patented technology

The invention belongs to the technical field of biological materials and ultrasonic printing, and particularly discloses a biological adhesive for ultrasonic printing and preparation and application thereof. The biological adhesive comprises a heat-sensitive main body material and a chemical adhesion component, the heat-sensitive main body material comprises hydroxybutyl chitosan, and the chemical adhesion component comprises polyacrylic acid-N-hydroxysuccinimide ester. The bioadhesive has excellent ultrasonic responsiveness, formability and bioadhesion performance, directional deposition, in-situ solidification and tissue surface adhesion can be achieved in a non-contact and accurately-controlled ultrasonic printing system, and the bioadhesive is suitable for various biomedical scenes such as tissue repair, minimally invasive medicine, biological device construction and drug delivery interface printing.

The preparation method specifically comprises the following steps: sequentially adding arginine and lipoic acid into a gelatin solution to obtain a hydrogel pre-polymerized solution; heating the hydrogel prepolymerization liquid to initiate a lipoic acid ring-opening polymerization cross-linking reaction, and adding a poly (3, 4-ethylenedioxythiophene) dispersion liquid modified by polydopamine to obtain gelatin / polylipoic acid conductive hydrogel; the preparation method comprises the following steps: heating and melting a lipoic acid monomer, then adding a cross-linking agent for reaction, then adding metal salt for stirring, and pouring the obtained yellow transparent liquid on the surface of the gelatin / polylipoic acid conductive hydrogel to obtain the double-layer heterogeneous biological adhesive. The invention also discloses an application of the double-layer heterogeneous biological adhesive in a biomedical adhesive. According to the method, strong interface connection between the two layers is achieved through the similar compatibility principle and the hot melting pouring technology, and layering is avoided during use; and the prepared adhesive has good tissue adhesion, self-repairing performance and biocompatibility.

The invention belongs to the technical field of biomedical materials, and particularly relates to a biological adhesive with stable performance and a preparation method and application thereof. Specifically, by regulating and controlling the mixing mode of the active ester and the amino cross-linking agent, an acidic polylysine hydrochloride aqueous solution is adopted as the amino cross-linking agent, the active ester is directly dissolved in the polylysine hydrochloride aqueous solution, and the formed solution mixing system is stable in performance, can be stably stored for 6 hours at room temperature, can be prepared by an operator before an operation, and is free of secondary pollution. And the device can be immediately used at any time in the operation, has good batch stability, and avoids individual difference, so that the device has important application value and market prospect.

A patch to be placed over an injury or defect in tissue in a biological structure having a lumen and preventing migration of contents of the biological structure through the injury or the defect. The patch includes an adhesive layer configured to adhere to the biological tissue via formation of hydrogen or covalent bonds with chemical groups present in the biological tissue and a backing layer coupled to and coextensive with the adhesive layer, the backing layer configured to be impervious to the contents.

There is provided a hemostatic bioadhesive including from 0.5 to 5 w / v % of chitosan or alginate measured as a weight percent of chitosan or alginate with respect to a total dry volume of the hemostatic bioadhesive, the chitosan or alginate being crosslinked and forming a first polymer network; from 0.5 to 13 w / v % of polyacrylamide or polyethylene glycol measured as a weight percent of polyacrylamide or polyethylene glycol with respect to the total dry volume of the hemostatic bioadhesive, the polyacrylamide or polyethylene glycol being crosslinked and forming a second polymer network, wherein the first polymer network and the second polymer network form a dissipative polymer matrix; and from 0 to 100 v / v % of an adhesive liquid infused in the dissipative polymer network. The hemostatic bioadhesives comprise interconnected pores in the dissipative polymer matrix having a size of 20 to 400 μm.

An antithrombotic surface-modified biomaterial is provided comprising a biomaterial substrate coated with a polymerizable dopamine-containing bioadhesive to which is attached one or more antithrombotic agents. A method of preparing the surface-modified biomaterial is also provided. The surface-modified biomaterial is beneficial for use in blood-contacting medical devices such as catheters, dialyzers and blood oxygenators to prevent or minimize the occurrence of thrombosis on the surface thereof.

The invention discloses an adhesive compound with an adhesive property optimized based on metal hydroxides as well as a preparation method and application of the adhesive compound, and belongs to the technical field of biological adhesives. The present invention relates to an adhesive composition comprising an adhesive precursor consisting of a protein-polyphenol composite hydrogel and a hydrogen bond destructive small molecule compound capable of network reconstitution comprising beta-folding formation in aqueous phase grafting comprising a metal hydroxide having the characteristics of: (a) a hydration enthalpy value of from-1000 kJ / mol to-4000 kJ / mol; (b) a dissociation constant of from 6 pKa to 13.5 pKa; (c) a water exchange rate of 105 S <-1 > to 10 < 10 > S <-1 >. The adhesion compound can be networked to form an advanced structure when encountering water, not only can generate underwater lap joint shear strength of more than 1MPa, but also can tolerate underwater long-term soaking and temperature change from-196 DEG C to 100 DEG C, and meanwhile, the adhesion compound also has good biocompatibility, can meet the requirement of the environment in a human body on tissue adhesion safety, and has good application prospects. Stability suitable for in vivo tissue repair and industrial applications is exhibited.

The invention belongs to the technical field of organic-inorganic compounding, and aims to solve the problem of treatment of temporomandibular joint osteoarthritis (TMJOA). Magnesium-gallic acid metal organic framework (Mg-GA MOF) particles are synthesized through a hydrothermal method, hyaluronic acid is subjected to hydroformylation and double-bond modification to obtain OHAMA, and the magnesium-gallic acid metal organic framework (Mg-GA MOF) particles and the OHAMA particles are compounded to prepare the MOF-Gel composite hydrogel. The hydrogel is injectable and high in tissue retention rate, has dual effects of inhibiting pyroptosis and promoting regeneration on condylar cartilage cells, can effectively promote cartilage repair, shows a good effect in TMJOA treatment, and has a wide application prospect.

A film and a method for use thereof such as for the administration of a biologically active agent or for therapy are provided. Specifically, a film, composed of a biodegradable material having a mucoadhesive surface comprising a plurality of mushroom-type structures is provided.

A patch to be placed over an injury or defect in tissue in a biological structure having a lumen and preventing migration of contents of the biological structure through the injury or the defect. The patch includes an adhesive layer configured to adhere to the biological tissue via formation of hydrogen or covalent bonds with chemical groups present in the biological tissue and a backing layer coupled to and coextensive with the adhesive layer, the backing layer configured to be impervious to the contents.

The present application relates to the technical field of biological adhesives, and particularly relates to a human tissue adhesive and a preparation method thereof, which comprises the following raw materials: modified polydopamine nanoparticles, sulfonated carbon nanotubes, selenium-calcium phosphate composite nanoparticles (Se-HAp NPs), growth factors, curcumin, quercetin, poly (N-isopropyl acrylamide) and polylactic acid. In the present application, the modified polydopamine nanoparticles significantly improve the wet-state adhesive strength of the adhesive, and the flexible nano-supporting effect of the sulfonated carbon nanotubes synergistically enhances the adhesion and flexibility thereof, and the two form a stable nano-network structure to support the uniform distribution of the Se-HAp NPs, the sulfonated carbon nanotubes ensure the functional integrity of the Se-HAp NPs in a dynamic environment, and the Se-HAp NPs together with the modified polydopamine nanoparticles improve the biological activity and stability of the adhesive, and promote tissue repair, so that the adhesive can adapt to a dynamic tissue environment.

The present invention discloses a degradable stent suitable for end-to-end anastomosis of bile ducts during liver transplantation, comprising a transverse stent assembly, a longitudinal stent assembly and a periodically degradable connecting assembly, a transverse tube body, a retaining net, a connecting sleeve, an end sleeve, an air-avoiding hole, a longitudinal tube body, a periodically degradable sleeve, and a periodically degradable filling block. Firstly, the transverse stent can achieve docking of donor bile ducts and recipient bile ducts of different diameters, thereby improving matching and applicability. The longitudinal stent can facilitate in vitro communication in the early stage of catheterization, thereby facilitating drainage and perfusion. Secondly, the periodically degradable sleeve and the periodically degradable filling block can be continuously degraded by the patient's body secretions and decompose after a certain period of time, thereby eliminating the docking between the transverse stent assembly and the longitudinal stent assembly, separating them, and facilitating the disassembly and removal of the longitudinal stent assembly. Finally, the grid structure of the retaining net can facilitate the accumulation of bioadhesives, thereby achieving the blocking of the retaining net. After the longitudinal stent assembly is separated from the transverse stent assembly, the transverse tube body in the transverse stent assembly is in a sealed state.

The invention relates to a composite material element (20), in particular for the manufacture of a glider as well as other boats and boat components. The composite material element (20) is characterized in that it has at least one inherently flame-retardant layer (22) of a cork material (24) and a biogenic binder (26). Furthermore, the invention relates to a method for manufacturing such a composite material element (20) and a slider (34) comprising composite material elements (20).

The present invention provides a hemostatic composite sponge comprising oxidized cellulose and an essentially gelatin-free bioadhesive material stably associated with said sponge and present in an organized pattern on said sponge.

The invention discloses a stem cell microcapsule-entrapped tissue adhesive, a preparation method and application, the tissue adhesive is composed of stem cell microcapsule-entrapped hydrogel and a biological adhesive, and live stem cells are entrapped in the tissue adhesive; the stem cells are selected from at least one of umbilical cord mesenchymal stem cells, bone marrow mesenchymal stem cells, adipose-derived stem cells, embryonic stem cells and induced pluripotent stem cells; the biological adhesive is formed by compounding a hydrophilic polymer and a block polymer, wherein the mass ratio of the hydrophilic polymer to the block polymer is (1: 5)-(5: 1); the transmittance of the tissue adhesive is 60-100%, the tissue adhesive strength is 20-200 kPa, and the volume swelling ratio is smaller than or equal to 50%. According to the scheme, the stem cell entrapped microcapsule and the biological adhesive are mixed to prepare the tissue adhesive, and the adhesive can be used as bio-ink to be assembled into a bionic scaffold through 3D printing or directly injected to an injured part, so that the tissue adhesive has a wide application prospect.

The invention discloses a dry and wet dual-purpose biological adhesive and a preparation method thereof.The preparation method comprises the steps that a polypeptide aqueous solution and a polyethylene glycol dimaleimide aqueous solution are mixed, the pH is adjusted to 7-8, and R-liquid is obtained; and mixing the R-liquid with a chelating agent, and drying to obtain the dry and wet dual-purpose biological adhesive. The designed Switch polypeptide can be complexed with Zn ions, after the Zn ions are introduced into R-liquid, the Switch polypeptide is subjected to conformation transformation from a random coil mode to a spiral coil coiling mode, and the change caused by the conformation transformation is mainly reflected in that hydrophilic and hydrophobic amino acids of the polypeptide can be spatially rearranged according to the spiral coil coiling rule; hydrophilic amino acids are completely exposed on the outer side, hydrophobic amino acids are orderly arranged on the inner side, hydrophobic side chains are also completely stretched, the hydrophobic amino acid side chains complete high-strength adhesion of polypeptide and an interface, and the biological adhesive achieves the adhesion effect according to the principle.

The present disclosure provides devices and methods for the treatment of ophthalmological conditions such as dry eye. Among the devices provided are punctal plugs and devices for inserting punctal plugs. The punctal plugs may be shaped for insertion in the punctum and / or the canaliculus. They may also be coated with a bioadhesive. Methods for inserting the punctal plugs are provided, as well as methods for preparing bioadhesive-coated punctal plugs. A method is also provided to treat dry-eye using a bioadhesive without use of a punctal plug.

The invention provides multifunctional bioadhesive hydrogel as well as a preparation method and application thereof, and relates to the technical field of biomedical materials. The preparation method comprises the following steps: dissolving dopamine modified gelatin (DA-Gel), sulphobetaine methacrylate (SBMA), acrylic acid (AA) and perfluoroalkyl ethyl methacrylate (PFEMA) in a dimethyl sulfoxide (DMSO) solution, uniformly stirring, injecting into a mold, carrying out cross-linking polymerization by adopting electron beam radiation without adding a chemical cross-linking agent, and preparing a hydrophobic film by adjusting the radiation absorption dose (0-50 kGy) and the hydrophobic monomer content. The mechanical property, the adhesion strength and the swelling behavior of the hydrogel can be accurately regulated and controlled, and the hydrogel with a three-dimensional interpenetrating network structure is obtained. The hydrogel prepared by the process can form rapid and tough adhesion on the surface of a moist tissue, effectively seal a wound, resist swelling in a body fluid environment and promote tissue regeneration, and has a wide clinical application prospect in the fields of wound hemostasis, surgical incision closure, viscera perforation repair and the like.

The present disclosure relates to an adhesive elastin and suckerin-based multiblock copolypeptide with stimulus responsiveness and surface adhesion, a self-assembled structure thereof, and application of an injectable hydrogel as a bioadhesive.

The invention discloses a preparation method of an asymmetric hydrogel modified membrane and application of the asymmetric hydrogel modified membrane to removal of ammonia nitrogen in landfill leachate, and the preparation method comprises the following steps: soaking a cut polytetrafluoroethylene flat sheet membrane in absolute ethyl alcohol, washing with distilled water, and drying to prepare a flat sheet membrane assembly; preparing bionic biological glue, vertically immersing the dried flat sheet membrane assembly into the bionic biological glue, avoiding bubble attachment, and ensuring complete immersion; preparing hydrogel, cooling the hydrogel, uniformly covering the hydrogel on a flat sheet membrane assembly, and depositing to obtain the asymmetric hydrogel modified membrane. When the asymmetric hydrogel modified membrane is applied to removal of ammonia nitrogen in landfill leachate, the landfill leachate is prevented from being in direct contact with a polytetrafluoroethylene substrate due to the anti-wetting and anti-pollution properties of the asymmetric hydrogel modified membrane, and compared with an original polytetrafluoroethylene membrane, the asymmetric hydrogel modified membrane has the advantages that the cost is reduced; the service life of the asymmetric hydrogel modified membrane is prolonged when the asymmetric hydrogel modified membrane is used for treating ammonia nitrogen of landfill leachate, the treatment capacity of the ammonia nitrogen is improved, and the removal rate of the ammonia nitrogen reaches 90% or above within 4 h.

The present invention relates to a biocompatible, tissue adhesive, chitosan flowable dressing, optionally modified with catechol, and suitable for treating bleeding in a physiological environment, e.g., gastrointestinal tract, bladder (in particular in connection with the TURP procedure). The characteristics and structures of the chitosan dressing are provided. Methods of making and using the chitosan dressing are also provided.

The application belongs to the field of medicine and health technology, and particularly relates to preparation and application of a novel bioadhesive with high biological adhesion and high biological compatibility for promoting peripheral nerve injury repair, which comprises the following steps: (1) grafting acetylcysteine and dopamine on chitosan to prepare modified chitosan gel with self-crosslinking performance as an adhesive layer; (2) preparing sodium alginate and polyacrylamide covalent / non-covalent double crosslinked gel with high strength and toughness as a substrate layer; and (3) uniformly coating the adhesive layer on the substrate layer, and cutting the adhesive layer into blocks of different sizes according to the requirements of use, so that the novel bioadhesive with high biological adhesion and high biological compatibility for promoting peripheral nerve injury repair is obtained.

The present disclosure pertains to bio-composites comprising plant biomass, a bio-binder, and a carbon nanomaterial, and a process for their preparation. The bio-composite materials of the present disclosure offer superior mechanical and thermal properties while being environmentally sustainable.

Among the various aspects of the present disclosure is the provision of a biological adhesive and methods of use thereof. A biological adhesive is described that limits complications from anastomotic leaks and provides a faster, simpler, and safer solution over the use of sutures. Methods of using the biological adhesive in single and double-layer tape form are also described.

A composition of matter useful as a bioadhesive including a bistable adhesive polymer. The bistable adhesive polymer includes one or more polymer backbones; side-chains attached to each of the polymer backbones; and one or more transition temperatures between a crystalline state and an amorphous state. The one or more transition temperatures are such that the polymer transitions from the crystalline state to the amorphous state upon physical contact with biological tissue having a temperature higher than the transition temperature. The polymer adheres or attaches to the biological tissue in the amorphous state and can be peeled from the biological tissue when cooled below the transition temperature to the crystalline state.

The invention discloses a lipoic acid eutectic adhesive which is prepared by the following steps: preparing small molecules of a lipoic acid hydroxyl derivative; the invention further discloses a preparation method of the lipoic acid eutectic adhesive. The preparation method is used for preparing the lipoic acid eutectic adhesive. According to the eutectic adhesive disclosed by the invention, the derivative small molecules and the lipoic acid are mixed according to a certain proportion, and a eutectic system is constructed under a solvent-free condition, so that the eutectic adhesive is in a molten state at room temperature, and meanwhile, the use of an organic solvent is also avoided, and the safety of a product is greatly improved; the eutecticevaporate adhesive provided by the invention has very remarkable responsiveness to ultraviolet light; the dithiolane ring-opening polymerization reaction can be effectively triggered through short irradiation of ultraviolet light so as to cure the adhesive, high and reliable adhesive strength and eutectic adhesive are achieved, the production process is simple, timely and effective, the service life is long, and the dithiolane ring-opening polymerization adhesive has a good application prospect in the fields of biological adhesives and industrial adhesives.

The invention relates to the technical field of hydrogel biological adhesives, in particular to a fluorinated polypropyleneimine graft modified hydrogel biological adhesive and a preparation method thereof. The problems existing in the prior art are as follows: a conventional hydrogel biological adhesive is easily influenced by a hydration layer on the surface of a biological tissue, so that close contact and interaction between adhesive molecules and the tissue are weak, and the wet adhesion strength is poor. Aiming at the technical problems, the invention provides the fluorinated polypropylene imine grafted modified hydrogel biological adhesive which is a hydrogel biological adhesive formed by carrying out physical cross-linking reaction and covalent cross-linking reaction on lipoic acid, polyethyleneimine and fluorinated polypropylene imine in an alkaline aqueous solution, and the structure of the hydrogel biological adhesive is formed by introducing a fluorinated group into F-PPI. The introduction of fluorinated groups can effectively repel a hydration layer on the surface of a biological tissue and promote close contact between adhesive molecules and a tissue interface, so that the problem of weak adhesive force of conventional hydrogel in a humid environment is solved.

The application belongs to the technical field of biomedical materials, and particularly relates to a biological adhesive with stable performance and a preparation method and application thereof. Specifically, by regulating a mixing mode of active ester and amino cross-linking agent, using an acidic polylysine hydrochloride aqueous solution as the amino cross-linking agent, directly dissolving the active ester in the polylysine hydrochloride aqueous solution, the solution mixing system formed has stable performance, can be stored at room temperature for 6 hours, an operator can prepare before operation, and can be used at any time during operation, and has good batch stability, avoids individual differences, and therefore has important application value and market prospect.

Disclosed herein are citrate-based mussel-inspired bioadhesives and methods of making and using the same. Also disclosed herein are methods of treating wounds.

The invention discloses an acid-resistant anti-swelling hydrogel biological adhesive as well as a preparation method and application thereof. The preparation method comprises the following steps: forming a uniform mixed solution from a carboxyl monomer, polymerizable cyclic lactam, zwitter-ions, a cross-linking agent and an initiator under magnetic stirring; adding the mixed solution into a polytetrafluoroethylene mold, isolating oxygen by using a glass sheet, and irradiating and curing under an ultraviolet lamp to obtain hydrogel; the hydrogel is placed in deionized water to be soaked for 24 hours, then constant-weight treatment is conducted, and the hydrogel is obtained after the constant-weight treatment is finished. The biological tissue adhesive prepared by a one-step method can effectively resist strong acidity and acid corrosion, has good adhesion stability in a water environment, and has strong adhesion, good tissue compliance and matched mechanical properties and biological safety on a wet interface. Meanwhile, the hydrogel has excellent mechanical property and self-repairing property, and particularly has wide biological application prospect in biological tissue repair in extreme environments such as gastric perforation repair.