95 results about "Bioadhesive" patented technology

The invention relates to the technical field of biological adhesives, in particular to a pH response type chitosan medical biological adhesive and a preparation and application method thereof.The preparation method includes the steps that phenylboronic acid modified chitosan, polyphenol compounds, cross-linking agents with different functional groups and polyethylene glycol with different molecular weights are evenly mixed in a PBS buffer solution with the pH equal to 7-8; and adjusting the pH value of the system to 7.5-8 by using a KOH aqueous solution, and standing at room temperature until the pH-responsive chitosan medical biological adhesive is formed. The chitosan biological adhesive disclosed by the invention still keeps excellent adhesive power in a moist environment, is rapid in adhesion, is non-toxic and biodegradable in material, has good biocompatibility, and effectively avoids secondary stitch removal pain caused by non-degradable materials. Due to the charge characteristic of the chitosan, the chitosan has good affinity with human tissues, is suitable for adhesion of various tissues, and has wide clinical application potential.

The invention belongs to the technical field of biological materials and ultrasonic printing, and particularly discloses a biological adhesive for ultrasonic printing and preparation and application thereof. The biological adhesive comprises a heat-sensitive main body material and a chemical adhesion component, the heat-sensitive main body material comprises hydroxybutyl chitosan, and the chemical adhesion component comprises polyacrylic acid-N-hydroxysuccinimide ester. The bioadhesive has excellent ultrasonic responsiveness, formability and bioadhesion performance, directional deposition, in-situ solidification and tissue surface adhesion can be achieved in a non-contact and accurately-controlled ultrasonic printing system, and the bioadhesive is suitable for various biomedical scenes such as tissue repair, minimally invasive medicine, biological device construction and drug delivery interface printing.

The preparation method specifically comprises the following steps: sequentially adding arginine and lipoic acid into a gelatin solution to obtain a hydrogel pre-polymerized solution; heating the hydrogel prepolymerization liquid to initiate a lipoic acid ring-opening polymerization cross-linking reaction, and adding a poly (3, 4-ethylenedioxythiophene) dispersion liquid modified by polydopamine to obtain gelatin / polylipoic acid conductive hydrogel; the preparation method comprises the following steps: heating and melting a lipoic acid monomer, then adding a cross-linking agent for reaction, then adding metal salt for stirring, and pouring the obtained yellow transparent liquid on the surface of the gelatin / polylipoic acid conductive hydrogel to obtain the double-layer heterogeneous biological adhesive. The invention also discloses an application of the double-layer heterogeneous biological adhesive in a biomedical adhesive. According to the method, strong interface connection between the two layers is achieved through the similar compatibility principle and the hot melting pouring technology, and layering is avoided during use; and the prepared adhesive has good tissue adhesion, self-repairing performance and biocompatibility.

The invention discloses a hydrogel for gastric perforation repair, which belongs to the field of bioadhesives. The technical scheme is as follows: a hydrogel for gastric perforation repair is generated by chemical reaction of compound A and compound B; compound A is a polyethylene glycol derivative A with a terminal active group α; the terminal active group α is succinimidyl succinate; compound B is a polyethylene glycol derivative B with a terminal active group β; the terminal active group β is an amino group; when compound A reacts with compound B, the terminal active group α and the terminal active group β chemically react to form an amide bond. The beneficial effects of the invention are as follows: the hydrogel for gastric perforation repair provided by the invention has a fast gelation speed, can be gelled in situ, is easy to use, has strong adhesion to gastric tissue, has a low swelling rate in simulated gastric fluid and PBS solution, has a strong ability to resist simulated gastric fluid corrosion, has good compression resistance and anti-peristalsis performance, has good biocompatibility, and can be safely degraded.

The invention belongs to the technical field of biomedical materials, and particularly relates to a biological adhesive with stable performance and a preparation method and application thereof. Specifically, by regulating and controlling the mixing mode of the active ester and the amino cross-linking agent, an acidic polylysine hydrochloride aqueous solution is adopted as the amino cross-linking agent, the active ester is directly dissolved in the polylysine hydrochloride aqueous solution, and the formed solution mixing system is stable in performance, can be stably stored for 6 hours at room temperature, can be prepared by an operator before an operation, and is free of secondary pollution. And the device can be immediately used at any time in the operation, has good batch stability, and avoids individual difference, so that the device has important application value and market prospect.

The invention discloses a rapidly cross-linked recombinant mussel adhesive protein adhesive as well as preparation and application thereof, and relates to the technical field of biological adhesives. According to the preparation method of the rapidly cross-linked recombinant mussel mucin adhesive, by changing the cross-linking mode of the recombinant mussel mucin, the dosage of the catalyst can be reduced, rapid cross-linking can be realized, and the mechanical property and viscoelasticity of the adhesive can be regulated and controlled according to requirements in the preparation process.

According to the present invention, there is provided a method for the production of an adhesive, said method comprising the following steps: a) providing lignin rich carbohydrate complexes (LCC) by pressurized hot water extraction of softwood biomass, preferably biomass of Norway spruce or Scots pine, or of hardwood biomass, preferably biomass of Birch or Beech, providing bark lignin rich carbohydrate complexes (BLCC) by pressurized hot water extraction of softwood bark, preferably bark of Norway spruce or Scots pine, or providing liquefied biomass by acid-catalyzed liquefaction of biomass including wood saw dust, agricultural residues, plant stalks, recycle carton boards, recycle paper, recycle wood, wood panels, and wood bark side streams, in polyhydric alcohols and phenols; b) reacting the LCCs, BLCCs, or liquefied biomass obtained in step a) with a crosslinking or catalytic agent selected from the group consisting of: carboxylic agents including citric acid, dicarboxylic acids including adipic acid, organic acid anhydrides, tannin, tannic acid, plant derived fatty acids including suberin, and hexamethylenediamine, in order to produce said adhesive. The present invention is also directed to an adhesive produced by the method of the invention and to the use thereof as a bonding agent in wood products or as a coating agent in wood products or mineral wool.

A patch to be placed over an injury or defect in tissue in a biological structure having a lumen and preventing migration of contents of the biological structure through the injury or the defect. The patch includes an adhesive layer configured to adhere to the biological tissue via formation of hydrogen or covalent bonds with chemical groups present in the biological tissue and a backing layer coupled to and coextensive with the adhesive layer, the backing layer configured to be impervious to the contents.

There is provided a hemostatic bioadhesive including from 0.5 to 5 w / v % of chitosan or alginate measured as a weight percent of chitosan or alginate with respect to a total dry volume of the hemostatic bioadhesive, the chitosan or alginate being crosslinked and forming a first polymer network; from 0.5 to 13 w / v % of polyacrylamide or polyethylene glycol measured as a weight percent of polyacrylamide or polyethylene glycol with respect to the total dry volume of the hemostatic bioadhesive, the polyacrylamide or polyethylene glycol being crosslinked and forming a second polymer network, wherein the first polymer network and the second polymer network form a dissipative polymer matrix; and from 0 to 100 v / v % of an adhesive liquid infused in the dissipative polymer network. The hemostatic bioadhesives comprise interconnected pores in the dissipative polymer matrix having a size of 20 to 400 μm.

The invention relates to an asymmetric bioadhesive patch with controllable modulus adhesion as well as a preparation method and application of the asymmetric bioadhesive patch. The asymmetric bioadhesive patch is of a double-layer composite gel structure and comprises an elastomer layer used for being adhered to a medical instrument and a hydrogel layer used for being adhered to soft tissue. The elastomer layer is prepared from the following raw material components: hexadecyl acrylate, a long-chain cross-linking agent and a photoinitiator; the raw materials of the hydrogel layer comprise any one of the following two groups of raw material components: acrylic acid, gelatin, acrylic acid N-hydroxysuccinimide ester, methacrylated gelatin, alpha-ketoglutaric acid and the balance of water; or acrylic acid, acrylic acid N-hydroxysuccinimide ester, N, N '-methylene bisacrylamide, alpha-ketoglutaric acid and the balance of water. Compared with the prior art, the two sides of the asymmetric bioadhesive patch can be adhered to medical equipment and soft tissue respectively, so that the medical equipment can be effectively fixed in the soft tissue.

An antithrombotic surface-modified biomaterial is provided comprising a biomaterial substrate coated with a polymerizable dopamine-containing bioadhesive to which is attached one or more antithrombotic agents. A method of preparing the surface-modified biomaterial is also provided. The surface-modified biomaterial is beneficial for use in blood-contacting medical devices such as catheters, dialyzers and blood oxygenators to prevent or minimize the occurrence of thrombosis on the surface thereof.

The invention discloses an adhesive compound with an adhesive property optimized based on metal hydroxides as well as a preparation method and application of the adhesive compound, and belongs to the technical field of biological adhesives. The present invention relates to an adhesive composition comprising an adhesive precursor consisting of a protein-polyphenol composite hydrogel and a hydrogen bond destructive small molecule compound capable of network reconstitution comprising beta-folding formation in aqueous phase grafting comprising a metal hydroxide having the characteristics of: (a) a hydration enthalpy value of from-1000 kJ / mol to-4000 kJ / mol; (b) a dissociation constant of from 6 pKa to 13.5 pKa; (c) a water exchange rate of 105 S <-1 > to 10 < 10 > S <-1 >. The adhesion compound can be networked to form an advanced structure when encountering water, not only can generate underwater lap joint shear strength of more than 1MPa, but also can tolerate underwater long-term soaking and temperature change from-196 DEG C to 100 DEG C, and meanwhile, the adhesion compound also has good biocompatibility, can meet the requirement of the environment in a human body on tissue adhesion safety, and has good application prospects. Stability suitable for in vivo tissue repair and industrial applications is exhibited.

The invention belongs to the technical field of organic-inorganic compounding, and aims to solve the problem of treatment of temporomandibular joint osteoarthritis (TMJOA). Magnesium-gallic acid metal organic framework (Mg-GA MOF) particles are synthesized through a hydrothermal method, hyaluronic acid is subjected to hydroformylation and double-bond modification to obtain OHAMA, and the magnesium-gallic acid metal organic framework (Mg-GA MOF) particles and the OHAMA particles are compounded to prepare the MOF-Gel composite hydrogel. The hydrogel is injectable and high in tissue retention rate, has dual effects of inhibiting pyroptosis and promoting regeneration on condylar cartilage cells, can effectively promote cartilage repair, shows a good effect in TMJOA treatment, and has a wide application prospect.

The present invention relates to an extracellular matrix-based adhesive composition and, particularly, provides a bioadhesive, a preparation method therefor, a use thereof, etc., in which the bioadhesive comprises an extracellular matrix-containing hydrogel, methacryloyl-substituted gelatin, and a gelatin curing agent, and has excellent bioadhesion and elasticity.

A film and a method for use thereof such as for the administration of a biologically active agent or for therapy are provided. Specifically, a film, composed of a biodegradable material having a mucoadhesive surface comprising a plurality of mushroom-type structures is provided.

A patch to be placed over an injury or defect in tissue in a biological structure having a lumen and preventing migration of contents of the biological structure through the injury or the defect. The patch includes an adhesive layer configured to adhere to the biological tissue via formation of hydrogen or covalent bonds with chemical groups present in the biological tissue and a backing layer coupled to and coextensive with the adhesive layer, the backing layer configured to be impervious to the contents.

The present application relates to the technical field of biological adhesives, and particularly relates to a human tissue adhesive and a preparation method thereof, which comprises the following raw materials: modified polydopamine nanoparticles, sulfonated carbon nanotubes, selenium-calcium phosphate composite nanoparticles (Se-HAp NPs), growth factors, curcumin, quercetin, poly (N-isopropyl acrylamide) and polylactic acid. In the present application, the modified polydopamine nanoparticles significantly improve the wet-state adhesive strength of the adhesive, and the flexible nano-supporting effect of the sulfonated carbon nanotubes synergistically enhances the adhesion and flexibility thereof, and the two form a stable nano-network structure to support the uniform distribution of the Se-HAp NPs, the sulfonated carbon nanotubes ensure the functional integrity of the Se-HAp NPs in a dynamic environment, and the Se-HAp NPs together with the modified polydopamine nanoparticles improve the biological activity and stability of the adhesive, and promote tissue repair, so that the adhesive can adapt to a dynamic tissue environment.

The present invention discloses a degradable stent suitable for end-to-end anastomosis of bile ducts during liver transplantation, comprising a transverse stent assembly, a longitudinal stent assembly and a periodically degradable connecting assembly, a transverse tube body, a retaining net, a connecting sleeve, an end sleeve, an air-avoiding hole, a longitudinal tube body, a periodically degradable sleeve, and a periodically degradable filling block. Firstly, the transverse stent can achieve docking of donor bile ducts and recipient bile ducts of different diameters, thereby improving matching and applicability. The longitudinal stent can facilitate in vitro communication in the early stage of catheterization, thereby facilitating drainage and perfusion. Secondly, the periodically degradable sleeve and the periodically degradable filling block can be continuously degraded by the patient's body secretions and decompose after a certain period of time, thereby eliminating the docking between the transverse stent assembly and the longitudinal stent assembly, separating them, and facilitating the disassembly and removal of the longitudinal stent assembly. Finally, the grid structure of the retaining net can facilitate the accumulation of bioadhesives, thereby achieving the blocking of the retaining net. After the longitudinal stent assembly is separated from the transverse stent assembly, the transverse tube body in the transverse stent assembly is in a sealed state.

The invention relates to a composite material element (20), in particular for the manufacture of a glider as well as other boats and boat components. The composite material element (20) is characterized in that it has at least one inherently flame-retardant layer (22) of a cork material (24) and a biogenic binder (26). Furthermore, the invention relates to a method for manufacturing such a composite material element (20) and a slider (34) comprising composite material elements (20).

The present invention provides a hemostatic composite sponge comprising oxidized cellulose and an essentially gelatin-free bioadhesive material stably associated with said sponge and present in an organized pattern on said sponge.

The invention discloses a stem cell microcapsule-entrapped tissue adhesive, a preparation method and application, the tissue adhesive is composed of stem cell microcapsule-entrapped hydrogel and a biological adhesive, and live stem cells are entrapped in the tissue adhesive; the stem cells are selected from at least one of umbilical cord mesenchymal stem cells, bone marrow mesenchymal stem cells, adipose-derived stem cells, embryonic stem cells and induced pluripotent stem cells; the biological adhesive is formed by compounding a hydrophilic polymer and a block polymer, wherein the mass ratio of the hydrophilic polymer to the block polymer is (1: 5)-(5: 1); the transmittance of the tissue adhesive is 60-100%, the tissue adhesive strength is 20-200 kPa, and the volume swelling ratio is smaller than or equal to 50%. According to the scheme, the stem cell entrapped microcapsule and the biological adhesive are mixed to prepare the tissue adhesive, and the adhesive can be used as bio-ink to be assembled into a bionic scaffold through 3D printing or directly injected to an injured part, so that the tissue adhesive has a wide application prospect.

The invention discloses a dry and wet dual-purpose biological adhesive and a preparation method thereof.The preparation method comprises the steps that a polypeptide aqueous solution and a polyethylene glycol dimaleimide aqueous solution are mixed, the pH is adjusted to 7-8, and R-liquid is obtained; and mixing the R-liquid with a chelating agent, and drying to obtain the dry and wet dual-purpose biological adhesive. The designed Switch polypeptide can be complexed with Zn ions, after the Zn ions are introduced into R-liquid, the Switch polypeptide is subjected to conformation transformation from a random coil mode to a spiral coil coiling mode, and the change caused by the conformation transformation is mainly reflected in that hydrophilic and hydrophobic amino acids of the polypeptide can be spatially rearranged according to the spiral coil coiling rule; hydrophilic amino acids are completely exposed on the outer side, hydrophobic amino acids are orderly arranged on the inner side, hydrophobic side chains are also completely stretched, the hydrophobic amino acid side chains complete high-strength adhesion of polypeptide and an interface, and the biological adhesive achieves the adhesion effect according to the principle.

The present disclosure provides devices and methods for the treatment of ophthalmological conditions such as dry eye. Among the devices provided are punctal plugs and devices for inserting punctal plugs. The punctal plugs may be shaped for insertion in the punctum and / or the canaliculus. They may also be coated with a bioadhesive. Methods for inserting the punctal plugs are provided, as well as methods for preparing bioadhesive-coated punctal plugs. A method is also provided to treat dry-eye using a bioadhesive without use of a punctal plug.

The invention provides multifunctional bioadhesive hydrogel as well as a preparation method and application thereof, and relates to the technical field of biomedical materials. The preparation method comprises the following steps: dissolving dopamine modified gelatin (DA-Gel), sulphobetaine methacrylate (SBMA), acrylic acid (AA) and perfluoroalkyl ethyl methacrylate (PFEMA) in a dimethyl sulfoxide (DMSO) solution, uniformly stirring, injecting into a mold, carrying out cross-linking polymerization by adopting electron beam radiation without adding a chemical cross-linking agent, and preparing a hydrophobic film by adjusting the radiation absorption dose (0-50 kGy) and the hydrophobic monomer content. The mechanical property, the adhesion strength and the swelling behavior of the hydrogel can be accurately regulated and controlled, and the hydrogel with a three-dimensional interpenetrating network structure is obtained. The hydrogel prepared by the process can form rapid and tough adhesion on the surface of a moist tissue, effectively seal a wound, resist swelling in a body fluid environment and promote tissue regeneration, and has a wide clinical application prospect in the fields of wound hemostasis, surgical incision closure, viscera perforation repair and the like.

The present disclosure relates to an adhesive elastin and suckerin-based multiblock copolypeptide with stimulus responsiveness and surface adhesion, a self-assembled structure thereof, and application of an injectable hydrogel as a bioadhesive.

The invention discloses a preparation method of an asymmetric hydrogel modified membrane and application of the asymmetric hydrogel modified membrane to removal of ammonia nitrogen in landfill leachate, and the preparation method comprises the following steps: soaking a cut polytetrafluoroethylene flat sheet membrane in absolute ethyl alcohol, washing with distilled water, and drying to prepare a flat sheet membrane assembly; preparing bionic biological glue, vertically immersing the dried flat sheet membrane assembly into the bionic biological glue, avoiding bubble attachment, and ensuring complete immersion; preparing hydrogel, cooling the hydrogel, uniformly covering the hydrogel on a flat sheet membrane assembly, and depositing to obtain the asymmetric hydrogel modified membrane. When the asymmetric hydrogel modified membrane is applied to removal of ammonia nitrogen in landfill leachate, the landfill leachate is prevented from being in direct contact with a polytetrafluoroethylene substrate due to the anti-wetting and anti-pollution properties of the asymmetric hydrogel modified membrane, and compared with an original polytetrafluoroethylene membrane, the asymmetric hydrogel modified membrane has the advantages that the cost is reduced; the service life of the asymmetric hydrogel modified membrane is prolonged when the asymmetric hydrogel modified membrane is used for treating ammonia nitrogen of landfill leachate, the treatment capacity of the ammonia nitrogen is improved, and the removal rate of the ammonia nitrogen reaches 90% or above within 4 h.

The present invention relates to a biocompatible, tissue adhesive, chitosan flowable dressing, optionally modified with catechol, and suitable for treating bleeding in a physiological environment, e.g., gastrointestinal tract, bladder (in particular in connection with the TURP procedure). The characteristics and structures of the chitosan dressing are provided. Methods of making and using the chitosan dressing are also provided.

The application belongs to the field of medicine and health technology, and particularly relates to preparation and application of a novel bioadhesive with high biological adhesion and high biological compatibility for promoting peripheral nerve injury repair, which comprises the following steps: (1) grafting acetylcysteine and dopamine on chitosan to prepare modified chitosan gel with self-crosslinking performance as an adhesive layer; (2) preparing sodium alginate and polyacrylamide covalent / non-covalent double crosslinked gel with high strength and toughness as a substrate layer; and (3) uniformly coating the adhesive layer on the substrate layer, and cutting the adhesive layer into blocks of different sizes according to the requirements of use, so that the novel bioadhesive with high biological adhesion and high biological compatibility for promoting peripheral nerve injury repair is obtained.

The present disclosure pertains to bio-composites comprising plant biomass, a bio-binder, and a carbon nanomaterial, and a process for their preparation. The bio-composite materials of the present disclosure offer superior mechanical and thermal properties while being environmentally sustainable.

The invention discloses a degradable stent suitable for bile duct end-to-end anastomosis in liver transplantation, which comprises a transverse stent assembly, a longitudinal stent assembly, a regularly degradable connecting assembly, a transverse tube body, a baffle net, a connecting sleeve, an end sleeve, a clearance hole, a longitudinal tube body, a regularly degradable sleeve and a regularly degradable filling block, firstly, butt joint of donor biliary tracts and recipient biliary tracts with different pipe diameters can be achieved through the transverse support, the matching degree and applicability are improved, in-vitro communication and drainage and perfusion are facilitated through the longitudinal support at the initial stage of catheter indwelling, secondly, the regularly degradable sleeve and the regularly degradable filling block can be continuously degraded by secretion in the body of a patient and decomposed after a certain period of time, and the catheter indwelling effect is improved. Butt joint of the transverse stent assembly and the longitudinal stent assembly is canceled, the transverse stent assembly and the longitudinal stent assembly are separated, the longitudinal stent assembly can be detached and taken out conveniently, finally, by means of the gridding structure of the blocking net, accumulation of the biological adhesive can be facilitated, the blocking net is blocked, and after the longitudinal stent assembly and the transverse stent assembly are separated, a transverse pipe body in the transverse stent assembly is in a sealed state.