33 results about "Bioadhesive" patented technology

The invention discloses an adhesive compound with an adhesive property optimized based on metal hydroxides as well as a preparation method and application of the adhesive compound, and belongs to the technical field of biological adhesives. The present invention relates to an adhesive composition comprising an adhesive precursor consisting of a protein-polyphenol composite hydrogel and a hydrogen bond destructive small molecule compound capable of network reconstitution comprising beta-folding formation in aqueous phase grafting comprising a metal hydroxide having the characteristics of: (a) a hydration enthalpy value of from-1000 kJ / mol to-4000 kJ / mol; (b) a dissociation constant of from 6 pKa to 13.5 pKa; (c) a water exchange rate of 105 S <-1 > to 10 < 10 > S <-1 >. The adhesion compound can be networked to form an advanced structure when encountering water, not only can generate underwater lap joint shear strength of more than 1MPa, but also can tolerate underwater long-term soaking and temperature change from-196 DEG C to 100 DEG C, and meanwhile, the adhesion compound also has good biocompatibility, can meet the requirement of the environment in a human body on tissue adhesion safety, and has good application prospects. Stability suitable for in vivo tissue repair and industrial applications is exhibited.

A film and a method for use thereof such as for the administration of a biologically active agent or for therapy are provided. Specifically, a film, composed of a biodegradable material having a mucoadhesive surface comprising a plurality of mushroom-type structures is provided.

The invention discloses a stem cell microcapsule-entrapped tissue adhesive, a preparation method and application, the tissue adhesive is composed of stem cell microcapsule-entrapped hydrogel and a biological adhesive, and live stem cells are entrapped in the tissue adhesive; the stem cells are selected from at least one of umbilical cord mesenchymal stem cells, bone marrow mesenchymal stem cells, adipose-derived stem cells, embryonic stem cells and induced pluripotent stem cells; the biological adhesive is formed by compounding a hydrophilic polymer and a block polymer, wherein the mass ratio of the hydrophilic polymer to the block polymer is (1: 5)-(5: 1); the transmittance of the tissue adhesive is 60-100%, the tissue adhesive strength is 20-200 kPa, and the volume swelling ratio is smaller than or equal to 50%. According to the scheme, the stem cell entrapped microcapsule and the biological adhesive are mixed to prepare the tissue adhesive, and the adhesive can be used as bio-ink to be assembled into a bionic scaffold through 3D printing or directly injected to an injured part, so that the tissue adhesive has a wide application prospect.

The invention discloses a dry and wet dual-purpose biological adhesive and a preparation method thereof.The preparation method comprises the steps that a polypeptide aqueous solution and a polyethylene glycol dimaleimide aqueous solution are mixed, the pH is adjusted to 7-8, and R-liquid is obtained; and mixing the R-liquid with a chelating agent, and drying to obtain the dry and wet dual-purpose biological adhesive. The designed Switch polypeptide can be complexed with Zn ions, after the Zn ions are introduced into R-liquid, the Switch polypeptide is subjected to conformation transformation from a random coil mode to a spiral coil coiling mode, and the change caused by the conformation transformation is mainly reflected in that hydrophilic and hydrophobic amino acids of the polypeptide can be spatially rearranged according to the spiral coil coiling rule; hydrophilic amino acids are completely exposed on the outer side, hydrophobic amino acids are orderly arranged on the inner side, hydrophobic side chains are also completely stretched, the hydrophobic amino acid side chains complete high-strength adhesion of polypeptide and an interface, and the biological adhesive achieves the adhesion effect according to the principle.

The invention provides multifunctional bioadhesive hydrogel as well as a preparation method and application thereof, and relates to the technical field of biomedical materials. The preparation method comprises the following steps: dissolving dopamine modified gelatin (DA-Gel), sulphobetaine methacrylate (SBMA), acrylic acid (AA) and perfluoroalkyl ethyl methacrylate (PFEMA) in a dimethyl sulfoxide (DMSO) solution, uniformly stirring, injecting into a mold, carrying out cross-linking polymerization by adopting electron beam radiation without adding a chemical cross-linking agent, and preparing a hydrophobic film by adjusting the radiation absorption dose (0-50 kGy) and the hydrophobic monomer content. The mechanical property, the adhesion strength and the swelling behavior of the hydrogel can be accurately regulated and controlled, and the hydrogel with a three-dimensional interpenetrating network structure is obtained. The hydrogel prepared by the process can form rapid and tough adhesion on the surface of a moist tissue, effectively seal a wound, resist swelling in a body fluid environment and promote tissue regeneration, and has a wide clinical application prospect in the fields of wound hemostasis, surgical incision closure, viscera perforation repair and the like.

The present disclosure relates to an adhesive elastin and suckerin-based multiblock copolypeptide with stimulus responsiveness and surface adhesion, a self-assembled structure thereof, and application of an injectable hydrogel as a bioadhesive.

The present invention relates to a biocompatible, tissue adhesive, chitosan flowable dressing, optionally modified with catechol, and suitable for treating bleeding in a physiological environment, e.g., gastrointestinal tract, bladder (in particular in connection with the TURP procedure). The characteristics and structures of the chitosan dressing are provided. Methods of making and using the chitosan dressing are also provided.

The invention discloses a lipoic acid eutectic adhesive which is prepared by the following steps: preparing small molecules of a lipoic acid hydroxyl derivative; the invention further discloses a preparation method of the lipoic acid eutectic adhesive. The preparation method is used for preparing the lipoic acid eutectic adhesive. According to the eutectic adhesive disclosed by the invention, the derivative small molecules and the lipoic acid are mixed according to a certain proportion, and a eutectic system is constructed under a solvent-free condition, so that the eutectic adhesive is in a molten state at room temperature, and meanwhile, the use of an organic solvent is also avoided, and the safety of a product is greatly improved; the eutecticevaporate adhesive provided by the invention has very remarkable responsiveness to ultraviolet light; the dithiolane ring-opening polymerization reaction can be effectively triggered through short irradiation of ultraviolet light so as to cure the adhesive, high and reliable adhesive strength and eutectic adhesive are achieved, the production process is simple, timely and effective, the service life is long, and the dithiolane ring-opening polymerization adhesive has a good application prospect in the fields of biological adhesives and industrial adhesives.

The invention relates to the technical field of hydrogel biological adhesives, in particular to a fluorinated polypropyleneimine graft modified hydrogel biological adhesive and a preparation method thereof. The problems existing in the prior art are as follows: a conventional hydrogel biological adhesive is easily influenced by a hydration layer on the surface of a biological tissue, so that close contact and interaction between adhesive molecules and the tissue are weak, and the wet adhesion strength is poor. Aiming at the technical problems, the invention provides the fluorinated polypropylene imine grafted modified hydrogel biological adhesive which is a hydrogel biological adhesive formed by carrying out physical cross-linking reaction and covalent cross-linking reaction on lipoic acid, polyethyleneimine and fluorinated polypropylene imine in an alkaline aqueous solution, and the structure of the hydrogel biological adhesive is formed by introducing a fluorinated group into F-PPI. The introduction of fluorinated groups can effectively repel a hydration layer on the surface of a biological tissue and promote close contact between adhesive molecules and a tissue interface, so that the problem of weak adhesive force of conventional hydrogel in a humid environment is solved.

The application belongs to the technical field of biomedical materials, and particularly relates to a biological adhesive with stable performance and a preparation method and application thereof. Specifically, by regulating a mixing mode of active ester and amino cross-linking agent, using an acidic polylysine hydrochloride aqueous solution as the amino cross-linking agent, directly dissolving the active ester in the polylysine hydrochloride aqueous solution, the solution mixing system formed has stable performance, can be stored at room temperature for 6 hours, an operator can prepare before operation, and can be used at any time during operation, and has good batch stability, avoids individual differences, and therefore has important application value and market prospect.

Disclosed herein are citrate-based mussel-inspired bioadhesives and methods of making and using the same. Also disclosed herein are methods of treating wounds.

The invention discloses an acid-resistant anti-swelling hydrogel biological adhesive as well as a preparation method and application thereof. The preparation method comprises the following steps: forming a uniform mixed solution from a carboxyl monomer, polymerizable cyclic lactam, zwitter-ions, a cross-linking agent and an initiator under magnetic stirring; adding the mixed solution into a polytetrafluoroethylene mold, isolating oxygen by using a glass sheet, and irradiating and curing under an ultraviolet lamp to obtain hydrogel; the hydrogel is placed in deionized water to be soaked for 24 hours, then constant-weight treatment is conducted, and the hydrogel is obtained after the constant-weight treatment is finished. The biological tissue adhesive prepared by a one-step method can effectively resist strong acidity and acid corrosion, has good adhesion stability in a water environment, and has strong adhesion, good tissue compliance and matched mechanical properties and biological safety on a wet interface. Meanwhile, the hydrogel has excellent mechanical property and self-repairing property, and particularly has wide biological application prospect in biological tissue repair in extreme environments such as gastric perforation repair.

The invention discloses a dual crosslinking mechanical self-adaptive biological adhesion hydrogel. The mechanical self-adaptive biological adhesion hydrogel is prepared from dopamine modified sodium alginate, bovine serum albumin and multi-arm polyethylene glycol-phthalic dicarboxaldehyde through dual covalent crosslinking. The hydrogel is endowed with the mechanical self-adaptive characteristic through the combined action of dopa and protein. Under the stress action and physiological oxidation environment, protein conformation in the hydrogel is expanded and cooperates with gradual oxidation of dopa, so that stress dissipation and adhesion strength self-enhancement along with time are realized while the material keeps flexibility, and long-term effective sealing of tissues can still be maintained under the condition of dynamic deformation. The hydrogel has the characteristics of active oxygen removal, antibiosis and enzyme response degradability, the whole system is composed of biomacromolecules and medical macromolecules, and the hydrogel has good biocompatibility and in-vivo degradability. And a new technical approach is provided for the sealed repair of airway fistula, gastrointestinal fistula and other tissue defects and the development of implantable bioadhesive materials.

The invention belongs to the technical field of biomedical materials, and particularly relates to a composite hydrogel system for reducing blood sugar of diabetic wounds and removing blood sugar reducing byproducts and a preparation method of the composite hydrogel system. The composite hydrogel system comprises calcium carbonate, horse radish peroxidase and glucose oxidase which are encapsulated in a sodium alginate-hyaluronic acid dopamine matrix, and the composite hydrogel system is obtained. According to the composite hydrogel system, in a hyperglycemia wound microenvironment, gluconic acid and hydrogen peroxide which are generated by catalyzing decomposition of glucose are respectively used as substrates to drive a double-stage cross-linking reaction, and finally, the double-network hydrogel is formed. The in-situ formation of the hydrogel is driven by utilizing the by-product derived from the wound microenvironment, the biological adhesive can be obtained without adding an exogenous cross-linking agent while efficient local blood glucose reduction is realized, the potential toxicity of a traditional cross-linking agent can be avoided, and the biological adhesive has a good application prospect. A safe, efficient and self-regulation new scheme is provided for local treatment of diabetes wounds.

The invention belongs to the technical field of biological adhesives, and provides a ball brush-aggregate composite biological adhesive as well as a preparation method and application of the ball brush-aggregate composite biological adhesive. A certain amount of nano spherical polyelectrolyte brush is added in the preparation process of a natural high-molecular polymer electrolyte composite coacervate to prepare the ball brush-coacervate composite biological adhesive. The natural high-molecular polymer electrolyte composite coacervate comprises a cationic natural high-molecular polymer and an anionic natural high-molecular polymer. Compared with a polyelectrolyte aggregate adhesive without ball brush doping, the ball brush-aggregate composite adhesive prepared by the invention shows higher adhesion strength and stability, and has a wide application prospect as a biological adhesive.

The application discloses a dry-wet type biological adhesive and a preparation method thereof, and the preparation method comprises the following steps: mixing a polypeptide aqueous solution and a polyethylene glycol dimaleimide aqueous solution, adjusting the pH to 7-8 to obtain R-liquid; and mixing the R-liquid with a chelating agent and drying to obtain the dry-wet type biological adhesive. The Switcch polypeptide designed in the application can complex Zn ions, and after the introduction of Zn ions into the R-liquid, the Switcch polypeptide performs a conformational transition from a random coil mode to a helical coil mode, and the change brought by the conformational transition is mainly reflected in that the hydrophilic and hydrophobic amino acids of the polypeptide are rearranged in space according to the rules of the helical coil winding; the hydrophilic amino acids are completely exposed on the outside, the hydrophobic amino acids are orderly arranged on the inside, the hydrophobic side chains are completely stretched, the hydrophobic amino acid side chains complete the high-strength adhesion of the polypeptide and the interface, and the biological adhesive realizes the adhesion effect according to the principle.

The invention provides a self-adaptive antibacterial biological adhesive based on 1, 2-dithiolane as well as a preparation method and application of the self-adaptive antibacterial biological adhesive based on 1, 2-dithiolane, and the molecular structure of the self-adaptive antibacterial biological adhesive based on 1, 2-dithiolane contains 1, 2-dithiolane. The self-adaptive antibacterial biological adhesive containing the molecular structure of 1, 2-dithiolane solves the problems that an existing adhesive for wound protection is insufficient in antibacterial performance, poor in adhesion, unmatched in mechanical performance, poor in biocompatibility, non-degradable, non-recyclable and the like in a complex wound environment.

The application discloses a starch-based bioadhesive and a preparation method and application thereof, and belongs to the technical field of biomedical materials. The adhesive aims to solve the technical problem that the existing bioadhesive cannot simultaneously realize strong wet-state tissue sealing and effective postoperative anti-adhesion. The starch derivative with a spiral cavity structure is used as a host, and a polymer containing a hydrophobic chain segment is used as a guest to pre-construct a "slidable topological entanglement network" through host-guest interaction, and the network is permanently fixed through light-induced covalent cross-linking. The unique structure enables the material to have excellent mechanical properties, strong wet-state adhesion (maintaining high adhesion strength to various tissues under various extreme physiological environments) and inherent anti-adhesion function (realized through a dense physical barrier). The adhesive can be in-situ formed by injection, is simple to operate, and has a wide application prospect in various surgical operations, such as gastrointestinal perforation repair, corneal laceration suture, internal organ hemostasis and the like, which require reliable sealing and anti-adhesion.

The present invention relates to the composition of a long-acting, bioadhesive endoparasiticidal gel based on an isoxazoline, alone or in combination with other antiparasitic agents. This gel exhibits a high level of adhesion to the oral mucosa and is highly palatable, greatly simplifying its dosage and preparation procedures. Ectoparasitosis is a parasitic condition caused by fleas, ticks, and mites that infest the superficial layers of the skin in small animals. Control of this disease is of great importance and readily achievable through the use of suitable antiparasitic agents such as isoxazolines, a chemical compound widely administered orally in tablet form due to the organoleptic and physicochemical characteristics of the compositions known to date.The present invention demonstrates that it is possible to administer isoxazolines in the pharmaceutical form of an oral gel at concentrations of up to 20.0% w / v, overcoming the organoleptic and physicochemical limitations of compositions known to date. These factors, never before included in oral ectoparasiticide compositions based on isoxazolines, represent a significant competitive advantage over existing compositions.

The present invention relates to a method for controlling the length of amyloid fibrils through a pressurized cutting process. Specifically, according to the present invention, long amyloid fibrils having a relatively long length can be uniformly cut into a desired specific length, and thus fibrils having a predetermined length can be produced precisely and reproducibly, thereby enabling cytotoxicity analysis according to the length of amyloid fibrils in neurodegenerative disease research. In addition, amyloid fibrils according to the present invention consistently maintain electrical properties, mechanical properties, and chemical reactivity due to the uniform and consistent length thereof, and thus may be suitable for commercial applications. In addition, since the pressurized cutting process of the present invention is relatively simple and economical, the commercial potential of various products and services using amyloid fibrils can be increased. Therefore, the pressurized cutting process is highly likely to be used in various technical fields such as neurodegenerative disease research, biosensors, filtration systems, nano-electronic devices, nanoparticles for drug screening, and bioadhesives.

A biological adhesive composition contains: a blended composition that contains a compound (A) having a polymerizable unsaturated bond and a polymer (B); and a polymerization initiator composition (C) that contains an organic boron compound. The biological adhesive composition has a glass transition temperature of less than 80°C obtained from measurement results by the method described in a specific "measurement conditions." The glass transition temperature is preferably from 10°C to less than 80°C. The compound (A) is preferably one or both of a compound represented by general formula (A)-1 and a compound having an amide structure and at least one polymerizable double bond.

The preparation method comprises the following steps: adding a cross-linking agent into polylipoic acid to carry out covalent cross-linking reaction, adding a stabilizer and a solvent, mixing to obtain a polymer binding phase solution, finally adding micron-sized flake silver powder, and fully mixing to obtain the conductive silver paste biological binding agent. The prepared conductive silver paste biological binder is suitable for a skin environment and is naturally dried and cured. Meanwhile, high conductivity, excellent skin adhesion, biocompatibility and environmental stability are realized.

A two-component composition including a first component A including water or an aqueous solution, and a second component B including a self-setting adhesive powder including at least a multivalent metal salt and phosphoserine, and at least one monocarbonate selected from the group of sodium carbonate, ammonium carbonate and potassium carbonate, wherein the monocarbonate is present in a concentration between 4 and 12% by weight of component B.

The application provides a low-eutectic bio-adhesive based on mixed polypeptides of Periplaneta americana and snake slough and a preparation method. Based on the application status of Periplaneta americana and snake slough in surgical diseases and external use drugs, the bio-adhesive fuses the optimal proportion of two animal polypeptide extracts and a low-eutectic solvent, and the three form a uniform composite system through a low-eutectic effect and a self-assembly process, is solidified at a diseased part through a preheating-cooling mode and plays a role. The low-eutectic solvent plays multiple roles as a cosolvent, a plasticizing excipient, a penetration enhancer, a bacteriostatic agent and an auxiliary functional substance. The preparation process is fast, the conditions are mild, special equipment is not needed and the process is easy to scale. The adhesive formula is simplified to the maximum extent, the raw materials are green, the system is stable, no other components are specially added, the operation is simple during use and the bio-adhesive is friendly and safe as an auxiliary treatment means. The whole system fully utilizes the unique activity and nursing efficacy of various components and can play a synergistic treatment role.

The present invention relates to some novel combinations of water-soluble hydrolyzed silk proteins and hyaluronic acid, or salts thereof, optionally together with bioadhesives, oral compositions comprising these combinations, and pharmaceutical compositions comprising these combinations. And their use in therapy, in particular for the prevention and / or treatment of esophagitis, and broadly for the prevention and / or treatment of esophageal epithelial cell damage.

The invention relates to the technical field of cultivation, and discloses a direct-current screen cabinet capable of efficiently dissipating heat and a three-dimensional breeding device for chamaecidae insects, the three-dimensional breeding device comprises a two-way box body, the two-way box body is provided with openings facing different directions, and a built-in frame part; the temperature adjusting system is arranged at the top of the two-way box body and is provided with a plurality of staggered humidity adjusting pipes and temperature adjusting pipes through a main pipe, and the humidity adjusting pipes and the temperature adjusting pipes are used for controlling the humidity and the temperature of the inner cavity of the two-way box body. The method comprises the following steps: firstly, mixing a compound microorganism bacterium agent, fresh medicine residues and a biological adhesive, compacting, at the moment, placing a fixed number of larvae in each culture hole according to culture requirements, and then stacking a plurality of plate bodies on the survival composite plate, the activity range of larvae can be effectively controlled, the larvae uniformly gnaw a culture medium from all points, and the proper number of larvae can be matched according to the weight of a survival composite board.

Disclosed is a bioadhesive material. The material includes a hydrogel formed from a pre-polymer solution that includes a gelatin species modified with polymerisable groups and a secondary biopolymer, the hydrogel having up to 20wt.% of the secondary biopolymer. The material also includes a membrane embedded in the hydrogel. Embodiments also relate to formation of the bioadhesive material, and uses thereof in soft tissue repair.

The present invention relates to lithiated polyamic acid derivatives and their use as binders in electrodes for lithium ion batteries.

This invention discloses a thrombus filter that is easy to fix and safely remove, relating to the field of medical device technology. The thrombus filter includes a filter screen made of metal wire and a retrieval hook at its proximal end. After the filter screen is released, both the distal and proximal ends have circumferentially evenly distributed petal-shaped mesh openings, the mesh size of which is smaller than that of the middle section mesh opening, and the mesh openings at both ends are staggered circumferentially. Multiple auxiliary positioning structures are provided at the maximum diameter of the filter screen. These structures include a positioning retaining ring and positioning spikes connected by biodegradable bioadhesive. These provide stable anchoring during initial implantation, and after the bioadhesive degrades, allow the positioning spikes and retaining ring to move relative to each other or separate, achieving minimally invasive removal. This invention balances reliable fixation during initial implantation with operational safety during removal, and also has a more significant thrombus-blocking effect.