5 results about "Antibiotic Agents" patented technology

Compounds and methods for combinatorial drug discovery in nanoliter droplets are described herein. More particularly, novel synergistic agents that increase efficacy of antibiotic agents to treat bacterial infections are described.

An orally administrable composition for maintaining oral health comprising as active ingredients an antibiotic agent, an anti-inflammatory agent and optionally a remineralizing agent is disclosed. Methods of using the composition for maintaining or improving oral health and for treating oral diseases or conditions by self-administration or by administration by a health care professional are also provided.

This disclosure relates to pentagalloyl glucose compositions and uses in managing microbial infections and compositions related thereto. In certain embodiments, this disclosure relates to compositions of pentagalloyl glucose. In certain embodiments, this disclosure relates to methods of treating or preventing a microbial infection, e.g., an antimicrobial resistant microbial infection, comprising administering to a subject in need thereof an effective amount of pentagalloyl glucose or salt thereof. In certain embodiments, the microbe is bacteria or fungi resistant to one or more antibiotic agents or antifungal agents.

Abstract Radiolabelled liposomes are provided for treating cancer. The radiolabelled liposomes comprise of a radionuclide such as 99mTc, 186Re, 188Re, or a combination thereof. The liposome may comprise a nanoliposome, a lipid, a phospholipid, cholesterol or a cholesterol analogue, and may further comprise a drug, chemotherapeutic agent, antibiotic agent or treatment molecule. In an embodiment, radiolabelled liposomes comprising (186Re) obisbemeda are administered to the patients. The radiolabelled liposomes may be administered as an infusate by intraventricular administration, including through an Ommaya reservoir, or by convection-enhanced delivery using one or more catheters. The therapies may further include imaging the radiolabelled liposome during or after administration. Abstract

Provided herein are methods for preventing or treating an infection caused by a Nontuberculous mycobacterium (NTM) species in a subject comprising administering to the subject an effective amount of an antibody or an antigen-binding fragment thereof that binds to a tip region of a DNABII peptide. Also provided in are methods for sensitizing a biofilm to an antibiotic agent, wherein the biofilm comprises a Nontuberculous mycobacterium (NTM) species, the method comprising contacting the biofilm with an antibody or an antigen-binding fragment thereof that binds to a tip region of a DNABII peptide.