41 results about "Bioabsorbable polymer" patented technology

Embodiments described herein relate to a support device configured to provide tissue support, during implant-based breast surgery. Embodiments described herein include a matrix sheet disposed in a foldable sheet including one or more templates including at least one of a partial support template and a full support template. The partial support template is configured for use in shaping the matrix sheet into a support device for partial coverage for a breast prosthesis. The full support template is configured for use in shaping the matrix sheet into a support device for full coverage for a breast prosthesis. In some embodiments, the support device is a bioabsorbable mesh substrate, a bioabsorbable polymer coating, and one or more active pharmaceutical agents for delivery at the surgical site. The support device may be provided in various shapes for coverage of the breast prosthesis or provided with templates for various coverage of the breast prosthesis. The support device forms a macroporous scaffold, and the macroporous scaffold may act as a lattice for new tissue ingrowth.

Embodiments described herein relate to a support device configured to provide tissue support, during implant-based breast surgery. Embodiments described herein include a matrix sheet disposed in a foldable sheet including one or more templates including at least one of a partial support template and a full support template. The partial support template is configured for use in shaping the matrix sheet into a support device for partial coverage for a breast prosthesis. The full support template is configured for use in shaping the matrix sheet into a support device for full coverage for a breast prosthesis. In some embodiments, the support device is a bioabsorbable mesh substrate, a bioabsorbable polymer coating, and one or more active pharmaceutical agents for delivery at the surgical site. The support device may be provided in various shapes for coverage of the breast prosthesis or provided with templates for various coverage of the breast prosthesis. The support device forms a macroporous scaffold, and the macroporous scaffold may act as a lattice for new tissue ingrowth.

A biodegradable, fiber-reinforced orthopedic staple for use in fixation of tissue and bone to restore anatomical relationships. The staple comprises a biocomposite composition including a bioabsorbable polymer and reinforcing mineral fibers. The staple further comprises a bridge portion attached to two or more shoulders, each of which is attached to a leg. The mineral fibers have at least two different lengths.

Embodiments described herein relate to a support device configured to provide tissue support, during implant-based breast surgery. Embodiments described herein include a matrix sheet (1002) disposed in a foldable sheet (1104) including one or more templates including at least one of a partial support template (1110a, 1110b) and a full support template (1120). The partial support template is configured for use in shaping the matrix sheet into a support device for partial coverage for a breast prosthesis. The full support template is configured for use in shaping the matrix sheet into a support device for full coverage for a breast prosthesis. In some embodiments, the support device is a bioabsorbable mesh substrate, a bioabsorbable polymer coating, and one or more active pharmaceutical agents for delivery at the surgical site. The support device may be provided in various shapes for coverage of the breast prosthesis or provided with templates for various coverage of the breast prosthesis. The support device forms a macroporous scaffold, and the macroporous scaffold may act as a lattice for new tissue ingrowth.

Embodiments described herein relate to a support device configured to provide tissue support, during implant-based breast surgery. Embodiments described herein include a matrix sheet disposed in a foldable sheet including one or more templates including at least one of a partial support template and a full support template. The partial support template is configured for use in shaping the matrix sheet into a support device for partial coverage for a breast prosthesis. The full support template is configured for use in shaping the matrix sheet into a support device for full coverage for a breast prosthesis. In some embodiments, the support device is a bioabsorbable mesh substrate, a bioabsorbable polymer coating, and one or more active pharmaceutical agents for delivery at the surgical site. The support device may be provided in various shapes for coverage of the breast prosthesis or provided with templates for various coverage of the breast prosthesis. The support device forms a macroporous scaffold, and the macroporous scaffold may act as a lattice for new tissue ingrowth.

A stent is disclosed that has an elongated body composed of a bioabsorbable polymer having a proximal end, a distal end, two open spiral channels formed on the exterior surface of the body to provide fluid communication between the proximal end and the distal end. The stent also has a central lumen open at the proximal and distal ends of the stent for the passage of a guide wire. A method for using the stent and a kit containing the stent are also disclosed.

The present disclosure provides a method for preventing blood coagulation, comprising administering an effective amount of ginsenoside compound K (CK) to a subject in need thereof. The present disclosure also provides a use of ginsenoside compound K (CK) in the manufacture of a medicament for preventing blood coagulation. The present disclosure further provides a drug-eluting percutaneous coronary intervention (PCI) device comprising a vascular implant, the surface of which is coated with a first layer comprising ginsenoside compound K (CK) and a first bioabsorbable polymer, the first bioabsorbable polymer comprising poly-L-lactic acid (PLLA) and poly(L-lactide-co-ε-caprolactone) (PLCL) in a mass ratio of 60%-80%:20%-40%.

Compressible adjuncts for use with a staple cartridge are provided. In one exemplary embodiment, the compressible adjunct includes a non-fibrous adjunct material formed of at least one fused bioabsorbable polymer. The adjunct material is configured to be releasably retained on a staple cartridge and is configured to be delivered to tissue by deployment of staples in the cartridge The adjunct material includes a lattice macrostructure having at least one drug contained therein. The lattice macrostructure is formed of a plurality of unit cells, in which each unit cell is configured to eject a predetermined amount of drug from the adjunct material and the predetermined amount of the drug being a function of a compression profile of the respective unit cell.

Disclosed herein are compositions comprising a polymer and a metabolic inhibitor, as well as a method of using the composition to modulate an immune response. The composition may be produced in the form of a synthetic tissue for provision in a subject. The composition or synthetic tissue may further comprise additional therapeutic agents.

Provided is an adhesion prevention film that sufficiently swells upon contact with moisture and is less prone to breaking. This adhesion prevention film contains a bioabsorbable polymer compound. The adhesion prevention film has a thickness of 10-500 µm, and a swelling ratio of 200-500 vol% after 15-minute immersion in phosphate buffer at pH 6.0. In the case where 1H-NMR measurement of the film is performed, using a sample solution prepared by adding the film and 1.2 mg of pyrazine to 1.1 mL of deuterated trifluoroacetic acid, with the resonance peak of pyrazine as a standard substance referenced to 9.45 ppm, when the integral value of the maximum resonance peak measured in the range of 9.4-9.5 ppm is defined as A and the integral value of the maximum resonance peak measured in the range of 5.0-5.2 ppm is defined as B, B / A is 0.10 or less.

A method of applying a buttress to a surgical stapler end effector comprises positioning a buttress assembly between an anvil and a staple cartridge of the end effector. The buttress assembly comprises a buttress body and an adhesive material. The adhesive material faces either an underside of the anvil or a deck of the staple cartridge. The anvil is in an open position relative to the staple cartridge during the act of positioning the buttress assembly between the anvil and the staple cartridge. The method further comprises moving the anvil toward the staple cartridge then moving the anvil back to the open position. The buttress assembly is adhered to the underside of the anvil or the deck of the staple cartridge via the adhesive material with the anvil moved back to the open position. The adhesive material comprises a bioabsorbable polymer.

Stapling assemblies for use with surgical staplers are provided. In one exemplary embodiment, the stapling assembly includes a cartridge having a plurality of staples disposed therein and a non-fibrous adjunct formed from at least one fused bioabsorbable polymer and configured to be releasably retained on the cartridge. Adjunct systems for use with surgical staplers are also provided. Surgical end effectors for use with the stapling assemblies are also provided. Methods for manufacturing and using the stapling assemblies are also provided.

The present invention provides a pharmaceutical composition which contains a population of cells, wherein the cells comprise cells that accumulate in an inflamed site and particles that are introduced into the cells and contain a bioabsorbable polymer and a drug, and the drug is cyclosporin or minoxidil.

To provide a depot for treating post-operative pain via sustained controlled release of a therapeutic agent.SOLUTION: In some embodiments, the depot may comprise a therapeutic region comprising an analgesic agent and a control region comprising a bioabsorbable polymer and a release agent admixed with the polymer. The release agent may be configured to dissolve when the depot is placed invivo to form a diffusion aperture in the control region. The depot may be configured to be implanted at a treatment site invivo and release the therapeutic agent at the treatment site for 3 days or more while implanted.SELECTED DRAWING: None

The present disclosure provides bioabsorbable particles with a nucleic acid. The bioabsorbable particles also include a bioabsorbable polymer matrix and a lipid salt. both of which can be altered to affect the particle properties. The bioabsorbable particles may be administered to a patient for the treatment of diseases. Methods for making and using the bioabsorbable particles are also provided.

A surgical fastener deployment system may include a plurality of coil fasteners having a head and coil body. In some embodiments, the head is comprised of a bioabsorbable polymer. In one embodiment, the coil body may be comprised of a shell and a core and one of the shell and the core may be comprised of one of a magnesium alloy or a bioabsorbable polymer, and the other of the shell and core is formed of the other of the magnesium alloy and the bioabsorbable polymer. The coil body may also include an internal channel which may have a support coil disposed within.

Long-acting resorbable subcutaneous implant with extended release of pre-concentrated pharmacologically active substance in polymer for treatment of chronic adrenal insufficiency. The implant is inserted subcutaneously and has continuous release of the active ingredient for an extended period of time. The implant may have in its constitution only hydrocortisone but is preferably formed by hydrocortisone particles homogeneously dispersed in a bio erodible and bioabsorbable polymer matrix. Such a polymer matrix may be formed of a polymer or a polymer blend. The release of the drug in this system occurs through diffusion, at a relatively constant rate, and it is possible to change the rate of release of the drug through the thickness or material of this membrane.

The invention relates to the technical field of veterinary medical instruments, and particularly discloses a veterinary absorbable orthopedic implant material and a preparation method thereof. The veterinary absorbable orthopedic implant material disclosed by the invention is prepared by mixing a bio-absorbable polymer and an inorganic substance in a weight ratio of (60-95): (5-40), the bioabsorbable polymer is selected from one or more of polylactic acid, poly-L-lactic acid and polyglycolic acid; the inorganic matter is selected from one or more of hydroxyapatite and calcium phosphate. According to the technical scheme, the absorbable orthopedic implant for livestock with excellent mechanical properties is obtained, the cost is low, and the biocompatibility is good.

Stapling assemblies for use with surgical staplers are provided. In one exemplary embodiment, the stapling assembly includes a cartridge having a plurality of staples disposed therein and a non-fibrous adjunct formed of at least one fused bioabsorbable polymer and configured to be releasably retained on the cartridge. Adjunct systems for use with surgical staplers are also provided. Surgical end effectors using the stapling assemblies are also provided.

The invention relates to a nerve regeneration inducing material. The present invention provides a non-tubular nerve regeneration inducing material for regenerating a nerve injury part, the material comprising: (A) a crosslinked body obtained by covalently crosslinking a bioabsorbable polysaccharide having a carboxyl group in the molecule with a low endotoxin with at least one crosslinking agent selected from the group consisting of compounds represented by general formula (I) and salts thereof; and (B) a bioabsorbable polymer. R1 HN-(CH2) n-NHR2 (I) [In the formula, R1 and R2 each independently represent a hydrogen atom or a group represented by the formula-COCH (NH2)-(CH2) 4-NH2, and n represents an integer of 2-18]. As a result, a medical material capable of inducing regeneration of a nerve injury part is provided.

A bioabsorbable lag screw 8 able to compress two fracture fragments together, comprising a body having a threaded outer section 10 and an axial longitudinal opening 16 extending therethrough. The opening comprises a square internal geometry at an internal position within the screw corresponding to the threaded outer section, the internal geometry extending between 20-100% of the length of the threaded outer section. The remaining length of the screw comprises a circular internal geometry. When rotational force is applied to the screw, it may be applied only to the threaded section via the square internal geometry. The screw may have a circular opening distal from the threaded section to allow an elongated cylindrical part of the driver to extend about 0.2mm from the opening. The screw may be 14-50mm in length. The screw may comprise or consist substantially of a bioabsorbable polymer.

Disclosed herein are compositions comprising a polymer and a metabolic inhibitor, as well as a method of using the composition to modulate an immune response. The composition may be produced in the form of a synthetic tissue for provision in a subject. The composition or synthetic tissue may further comprise additional therapeutic agents.

This disclosure relates to scaffolds made of a braid of bioabsorbable polymeric fibers for implantation within a lumen of a mammalian body and, in particular, to such scaffolds that are configured to divert blood flow from a pathology associated with a blood vessel.

Stapling assemblies for use with surgical staplers are provided. In one exemplary embodiment, the stapling assembly includes a cartridge having a plurality of staples disposed therein and a non-fibrous adjunct formed from at least one fused bioabsorbable polymer and configured to be releasably retained on the cartridge. Adjunct systems for use with surgical staplers are also provided. Surgical end effectors for use with the stapling assemblies are also provided. Methods for manufacturing and using the stapling assemblies are also provided.

Compressible adjuncts for use with a staple cartridge are provided. In one exemplary embodiment, the compressible adjunct includes a non-fibrous adjunct material formed of at least one fused bioabsorbable polymer. The adjunct material is configured to be releasably retained on a staple cartridge and is configured to be delivered to tissue by deployment of staples in the cartridge The adjunct material includes a lattice macrostructure having at least one drug contained therein. The lattice macrostructure is formed of a plurality of unit cells, in which each unit cell is configured to eject a predetermined amount of drug from the adjunct material and the predetermined amount of the drug being a function of a compression profile of the respective unit cell.

Provided is a non-tubular brain damage recovery material which is used to cover and / or fill a damaged part of the brain, the brain damage recovery material including: (A) a cross-linked body with which a bioabsorbable polysaccharide having a carboxyl group in a low endotoxin molecule is covalently bonded and cross-linked with at least one crosslinking reagent selected from among a compound represented by general formula (I) and salts thereof; and (B) a bioabsorbable polymer. R1HN—(CH2)n—NHR2 (I) [in the formula, R1 and R2 each independently represent a hydrogen atom or a group represented by formula of —COCH(NH2)—CH2]4—NH2, and n represents an integer from 2 to 18]. Accordingly, provided is a medical material which can recover a damaged part of the brain.

A non-tubular material for nerve regeneration induction, which can be used for the regeneration of a damaged part in a nerve, and which comprises: (A) a crosslinked form produced by crosslinking a low-endotoxin bioabsorbable polysaccharide having a carboxyl group in the molecule with at least one crosslinkable reagent selected from a compound represented by general formula (I) and a salt thereof via covalent bonds; and (B) a bioabsorbable polymer. R1HN—(CH2)n—NHR2 (I), wherein R1 and R2 independently represent a hydrogen atom or a group represented by formula: —COCH(NH2)—(CH2)4—NH2, and n represents an integer of 2 to 18. Thus, a medical material that can induce the regeneration of a damaged part in a nerve is provided.

Stapling assemblies for use with surgical staplers are provided. In one exemplary embodiment, the stapling assembly includes a cartridge having a plurality of staples disposed therein and a non-fibrous adjunct formed from at least one fused bioabsorbable polymer and configured to be releasably retained on the cartridge. Adjunct systems for use with surgical staplers are also provided. Surgical end effectors for use with the stapling assemblies are also provided. Methods for manufacturing and using the stapling assemblies are also provided.

A stent is disclosed that has an elongated body composed of a bioabsorbable polymer having a proximal end, a distal end, two open spiral channels formed on the exterior surface of the body to provide fluid communication between the proximal end and the distal end. The stent also has a central lumen open at the proximal and distal ends of the stent for the passage of a guide wire. A method for using the stent and a kit containing the stent are also disclosed.

The invention relates to an absorbable surgical suture and a preparation method thereof, the surgical suture takes a bioabsorbable polymer as a main body material, and the bioabsorbable polymer comprises the following raw materials: a polyglycolide copolymer, a function enhancer and an optional coloring agent, polymeric monomers of the polyglycolide copolymer comprise glycolide and comonomers selected from one or more of lactide, caprolactone, trimethylene carbonate and p-dioxanone, and the function enhancer is selected from at least one of a carbodiimide compound, an oxazoline compound, an isocyanate compound and an epoxy compound. By adding a small amount of function enhancer into the polyglycolide copolymer, the mechanical retentivity of the polymer is enhanced, the degradation time of the polymer is not affected, and compared with the prior art, the surgical suture has better fracture strength retentivity and stability.