12 results about "Polyanhydrides" patented technology

The present invention relates to a method for preparing a crosslinked polyester of glycerol and of an aliphatic monomer chosen from a dicarboxylic acid and a diester of a dicarboxylic acid, comprising a step of crosslinking a polyester of glycerol and an aliphatic monomer chosen from a dicarboxylic acid and a diester of a dicarboxylic acid with a cyclic carboxylic polyanhydride A in the presence of a sulfonic acid compound, the cyclic carboxylic polyanhydride A comprising at least two cyclic carboxylic anhydride groups, the cyclic carboxylic polyanhydride A not comprising linear carboxylic anhydride functions. The present invention also relates to a crosslinking composition useful for implementing the method of the invention.

The present invention relates to the use of a cyclic carboxylic polyanhydride A, the cyclic carboxylic polyanhydride A comprising at least two cyclic carboxylic anhydride groups, and not comprising a linear carboxylic anhydride function, as a crosslinking agent for a polyester of glycerol and a dicarboxylic acid, so as to increase the bioresorbability and / or the degradation in aqueous medium of a polyester of glycerol and a crosslinked dicarboxylic acid, in particular compared to a polyester of glycerol and a thermally crosslinked dicarboxylic acid in the absence of a crosslinking agent, and advantageously in the absence of cyclic carboxylic polyanhydride A.

A class of biodegradable, surface-eroding cyclic poly(methacrylic anhydride) (PMAA) polymer-based biomaterials that are useful as bone cement or bio-adhesives. The synthesis of the biomaterials involves the preparation of linear cyclic PMAA prepolymers. The biomaterials may be further processed to make bone cement for orthopedic applications. Extensive testing of the biomaterials has confirmed that they are biodegradable, have a peak exotherm that is below 45° C., have no or negligible shrinkage, and have good mechanical properties. The biomaterials therefore provide advantages over commercial poly(methyl methacrylate) (PMMA) based bone cements that are currently used in medical applications ranging from dentistry to orthopedics.

The present invention provides novel bioactive and biocompatible polymers derived from salicylic acid and itaconic acid. The present invention also provides hydrogels formed from these bioactive and biocompatible polymers, and methods of using such hydrogels to promote plant growth and / or to increase drought and stress tolerance.

The present invention relates to a process for preparing a crosslinked glycerol polyester and a dicarboxylic acid monomer, comprising a step of crosslinking a glycerol polyester and a dicarboxylic acid monomer with a cyclic carboxylic polyanhydride A in the presence of a metal triflate (or trifluoromethylsulfonate) compound, the cyclic carboxylic polyanhydride A comprising at least two cyclic carboxylic anhydride groups, the cyclic carboxylic polyanhydride A not comprising linear carboxylic anhydride functions, and the metal of the metal triflate (or trifluoromethylsulfonate) compound being selected from scandium, yttrium, the lanthanides, bismuth, gallium, indium, tin, thallium, aluminum, iron, copper, zinc, cadmium, titanium, zirconium, niobium, ruthenium, silver, the tungsten, platinum and hafnium.The present invention also relates to a crosslinking composition useful for implementing the process of the invention.

Disclosed are compositions and methods for vaccinating susceptible individuals against infection by respiratory syncytial virus (RSV). The disclosed compositions include vaccine compositions comprising an effective amount of respiratory syncytial virus (RSV) F protein in a pre-fusion stabilized form and / or M protein incorporated into biodegradable polyanhydride polymer particles for inducing an immune response against RSV. The vaccine compositions also may include a suitable adjuvant.

The present invention relates to a process for preparing a crosslinked glycerol polyester and a dicarboxylic acid monomer, comprising a step of crosslinking a glycerol polyester and a dicarboxylic acid monomer with a cyclic polycarboxylic anhydride A in the presence of a sulfonic acid compound, the cyclic polycarboxylic anhydride A comprising at least two cyclic carboxylic anhydride groups, the cyclic polycarboxylic anhydride A not comprising any linear carboxylic anhydride functions. The present invention also relates to a crosslinking composition useful for carrying out the process of the invention.

The present invention relates to a method for preparing a crosslinked polyester of glycerol and of an aliphatic carboxylic diacid or diester monomer, comprising a step of crosslinking a polyester of glycerol and of an aliphatic carboxylic diacid or diester monomer with a cyclic carboxylic polyanhydride A, the cyclic carboxylic polyanhydride A comprising at least two cyclic carboxylic anhydride groups, the cyclic carboxylic polyanhydride A not comprising linear carboxylic anhydride functions. The present invention also relates to a crosslinking composition which can be used to implement the method of the invention, and also to the crosslinked polyester obtained in this way.

The present invention relates to a method for preparing a crosslinked polyester of glycerol and of an aliphatic monomer selected from a dicarboxylic acid and a diester of a dicarboxylic acid, the method comprising a step of crosslinking a polyester of glycerol and of an aliphatic monomer selected from a dicarboxylic acid and a diester of a dicarboxylic acid with a cyclic carboxylic polyanhydride A in the presence of a metal triflate (or trifluoromethylsulphonate) compound, wherein the cyclic carboxylic polyanhydride A comprises at least two cyclic carboxylic anhydride groups, wherein the cyclic carboxylic polyanhydride A does not comprise linear carboxylic anhydride functions, and wherein the metal of the metal triflate (or trifluoromethylsulphonate) compound is selected from scandium, yttrium, lanthanides, bismuth, gallium, indium, tin, thallium, aluminium, iron, copper, zinc, cadmium, titanium, zirconium, niobium, ruthenium, silver, tungsten, platinum and hafnium. The present invention also relates to a crosslinking composition that may be used for implementing the method according to the invention.

The present invention relates to a process for preparing a crosslinked glycerol polyester, comprising a step of crosslinking a glycerol polyester with a cyclic carboxylic polyanhydride A in the presence of a metal triflate (or trifluoromethylsulfonate) compound, the cyclic carboxylic polyanhydride A comprising at least two cyclic carboxylic anhydride groups, the cyclic carboxylic polyanhydride A not comprising any linear carboxylic anhydride functions, and the metal of the metal triflate (or trifluoromethylsulfonate) compound being selected from the alkali and alkaline earth metals. The present invention also relates to a crosslinking composition useful for carrying out the process of the invention.

This present disclosure provides RNA expression systems based on sequences from plant viruses, insect viruses, and flaviviruses that eliminate the need for expensive modifications. Methods to express and package an RNA polynucleotide without the need for in vitro transcription and lipid nanoparticles are provided. Also provided are methods to package an RNA polynucleotide using synthetic polyanhydride nanoparticles that are stable at room temperature and suitable for delivery by nasal spray.

The present invention relates to the use of a cyclic carboxylic polyanhydride A, the cyclic carboxylic polyanhydride A comprising at least two cyclic carboxylic anhydride groups, and not comprising a linear carboxylic anhydride function, as a crosslinking agent for a polyester of glycerol and of an aliphatic carboxylic diacid or diester monomer, so as to increase the bioresorbability and / or degradation in aqueous medium of a polyester of glycerol and of a crosslinked aliphatic carboxylic diacid or diester monomer, in particular compared to a polyester of glycerol and of a thermally crosslinked aliphatic carboxylic diacid or diester monomer in the absence of a crosslinking agent, and advantageously in the absence of cyclic carboxylic polyanhydride A.