24 results about "Polydioxanone" patented technology

The invention discloses an anti-adhesion membrane loaded with nintedanib and a preparation method of the anti-adhesion membrane loaded with the nintedanib. The anti-adhesion membrane loaded with the nintedanib is prepared from a drug-loading substrate material and the nintedanib through electrostatic spinning, the material of the drug-loading substrate is one or more of polylactic acid, poly (p-dioxanone), a polylactic acid-glycolic acid copolymer, polycaprolactone and polyethylene glycol; a solvent adopted in the electrostatic spinning is hexafluoroisopropanol, and the voltage adopted in the electrostatic spinning is 10-14 kV. The nintedanib-loaded anti-adhesion membrane has the advantages that the tensile strength and the elongation at break are obviously improved, the mechanical property is obviously improved, the fiber distribution is uniform, the obvious anti-adhesion effect is realized, the nintedanib-loaded anti-adhesion membrane is suitable for common laparotomy, and the application prospect is wide.

The invention discloses a high molecular weight poly (p-dioxanone) (PPDO) microsphere as well as a preparation method and application thereof. By adopting a double emulsification-solvent evaporation method, an amphiphilic polymer, such as poly (p-dioxanone) (PDO) or a copolymer of PDO and a hydrophilic fragment (such as mPEG and mPPG), is utilized to perform self-assembly on a two-phase interface formed by emulsification under the combined action of amphipathy and polyvinyl alcohol (PVA) to form a double-micelle protective layer, so that the degradation effect of water on PPDO in the microsphere forming process is effectively blocked, and the PPDO can be effectively degraded. And finally, the high-molecular-weight poly (p-dioxanone) microspheres with stable performance are obtained, so that the high-molecular-weight PPDO microspheres have long-term stability. The preparation method is high in operability, mild in condition and suitable for large-scale production, high-molecular-weight poly (p-dioxanone) microspheres are obtained, and the preparation method has wide application prospects in the aspects of tissue filling agents, drug carriers, tissue scaffolds and the like.

The invention discloses a poly (p-dioxanone) polymer and other polymer material blank microspheres, and belongs to the technical field of biological medicines. The process is as follows: polydioxanone is dissolved in hexafluoroisopropanol, and the proportion of polydioxanone to hexafluoroisopropanol is 1%-10%; the polyvinyl alcohol is dissolved in water, the proportion of the polyvinyl alcohol to the water is 1%-10%, and the proportion of the polydioxanone solution to the polyvinyl alcohol solution is 0.1%-10%; dispersing the two solutions at the rotating speed of 5000 to 15000 for 0.5 to 5 minutes; stirring the suspension until the organic solvent is completely volatilized, standing and layering the suspension, and decanting supernate; adding water to wash the precipitate, carrying out centrifugal filtration, repeating for three times, removing the supernatant, and then carrying out vacuum drying; the prepared biodegradable material has the particle size of 10-100 microns, is used for human body injection filling, is simple to operate, good in repeatability, low in cost, high in safety in the preparation process, easy to industrialize, good in hydrolyzability, excellent in biocompatibility and bioabsorbable, and is used for human body injection filling.

The present invention relates to a dental / medical device consisting of an absorbable synthetic membrane, preferably in the color of white to gray, comprising poly (dioxanone) and optionally graphene and stem cells for guided tissue reconstruction and / or regeneration of bone defects and other connective tissues, such as gingiva, skin, cartilage or cornea. Furthermore, the invention relates to the use of said device for the above related applications and to a method for producing said device.

The utility model discloses a poly (p-dioxanone) medical suture with an anti-inflammation capsule, and relates to the technical field of medical sutures. The protein anti-inflammatory suture line comprises a suture line inner core, a protein adhesive layer, a protein microcapsule and anti-inflammatory drug particles, wherein the suture line inner core is made of a PPDO material. According to the utility model, the anti-inflammatory drug of the wound can be fully and comprehensively absorbed; the inner core of the suture line has good compatibility, and rejection and tissue inflammation are reduced; the suture line can be gradually degraded in the body and finally converted into carbon dioxide, water and the like, and the carbon dioxide, the water and the like are naturally discharged by the human body and do not need to be removed through a secondary operation, so that the infection risk possibly caused by the secondary operation is reduced, and the infection risk is reduced; the suture line has long strength maintenance time and can provide continuous support for the wound until the tissue is healed; the protein microcapsules and the anti-inflammatory drug particles are beneficial to reducing inflammatory reaction.

The invention discloses a chemical indicator card for monitoring low-temperature steam formaldehyde sterilization, which belongs to the technical field of medical treatment and public health sterilization monitoring, and is composed of a Tyvek paper carrier and chemical indicator ink mixed by multiple chemicals, and the carrier has the length of 70.4 + / -1mm and the width of 8.8 + / -0.5 mm; the indicating ink can generate controllable color change according to the concentration, temperature and time of formaldehyde sterilization by adjusting the component proportion; the indicator card is matched with a semicircular loading box made of an ABS (Acrylonitrile Butadiene Styrene) material, a polytetrafluoroethylene tube with a specific size is arranged in the box, when the color is successfully changed, 0.9 ml of hydrogen peroxide is injected, and sterilization is carried out for 210 seconds, and when the color is failed, 0.6 ml of hydrogen peroxide is injected at the same temperature at the same time. The indicator card is simple in structure and convenient to use, adapts to PCD scenes, fills up related gaps in China, improves the sterilization monitoring accuracy and provides guarantee for sterilization of lumen type instruments.

The present invention discloses a polydioxanone and its preparation method and application, in particular its application in medical materials (e.g., sutures). The polydioxanone has a specific molecular weight and molecular weight distribution, is highly stable, has a long shelf life, is advantageous for storage and use, and has good processing properties. The polymer fiber prepared using the polydioxanone is easily formed, has high breaking strength, and has good performance in use. The polydioxanone is suitable for preparing surgical sutures and for preparing medical dressings, anti-adhesion materials, orthopedic repair materials, tissue engineering scaffolds, and other medical materials by weaving the fibers. The polydioxanone can also be used to prepare products such as drug carriers, and has good application value. The preparation method of the polydioxanone provided by the present invention is simple to operate, has readily available raw materials, uses a small amount of catalyst, has low cost, is suitable for industrial production, and in particular can obtain polydioxanone with a more regular and narrower molecular weight distribution.

The present invention relates to a dental / medical device consisting of an absorbable synthetic membrane, preferably white to gray in color, comprising poly(dioxanone) and optionally graphene and stem

A thread-lifting surgical procedure employs an inferior-to-superior method of thread insertion through one or more deep cheek tissue pads, which angles the deep cheek tissue fat pads upward and inward. An inferior-to-superior method of thread insertion is also used for gonial angle insertion vectors through the superficial fat pads. A method for marking the patient prior to performing the thread-lifting surgical procedure is also provided. A computer and computerized method are disclosed for automated planning, execution and display of the present invention.

The present invention provides an absorbable ligating clip, which comprises an inner clip and an outer clip; the inner clip comprises an inner layer structure and an outer layer structure; the inner layer structure comprises polydioxanone, polyethylene glycol-polydioxanone copolymer and magnesium; the outer layer structure comprises polylactic acid-polydioxanone copolymer. Compared with the prior art, the inner clip of the absorbable ligating clip provided by the present invention comprises two-layer structure, the inner layer part is soft, which can play a role in protecting human blood vessels, avoiding blood vessel injury during surgical clamping, and at the same time adding magnesium powder and polyethylene glycol-polydioxanone copolymer to increase hydrophilicity, greatly shortening the degradation time of the inner clip, making the degradation times of the inner clip and the outer clip tend to be consistent; the outer layer adopts polylactic acid-polydioxanone copolymer, which is harder than the inner layer material, improving the disadvantages of the polydioxanone material such as easy overflow of materials during processing, difficult demolding, and easy strain and deformation of products, achieving the dual effects of easy processing of products and protection of blood vessels.

The present invention relates to a dental / medical device consisting of an absorbable synthetic membrane, preferably white to gray in color, comprising poly(dioxanone) and optionally graphene and stem cells, to be used in guided tissue reconstruction and / or regeneration of bone defects and other connective tissues (gum, skin, cartilage or cornea, for example). Furthermore, the present invention relates to the use of said device for the above-related applications and to the process of preparing said device.

The present invention relates to an electrospun multilayer tube or wrap for the protection or bridging of damaged nerves, comprising an electrospun isolating outer layer and at least one electrospun inner layer, the electrospun isolating outer layer comprising at least one polymer selected from the group consisting of polycaprolactone, polylactide, polyglycolide, polytrimethylene carbonate, polydioxanone, polyethylene glycol, polyurethane, copolymers thereof or mixtures thereof, the at least one electrospun inner layer comprising an agent capable of forming a covalent bond with proteins and peptides, the agent comprising at least one group selected from the group consisting of N-hydroxysuccinimide, maleimide, thio-NHS, biotin-NHS, carboxylic acid or aldehyde. Furthermore, the present invention relates to a method of manufacturing such a tube or wrap and to their use for the protection or bridging of nerves or for stimulating nerve growth and cell proliferation.

This application relates to the field of medical suture technology, specifically disclosing a PDO barbed suture with an antibacterial coating and its preparation method. The PDO barbed suture with an antibacterial coating is prepared by blending and spinning a PDO mixed suture matrix with polylactic acid (PLA) and polydioxanone (PD-dioxanone) in a certain proportion to obtain a PDO mixed suture matrix with good mechanical properties. Then, using hyaluronic acid as a gel matrix, 4-(ethylene oxide-2-ylmethoxy)butyl acrylate is grafted onto the hyaluronic acid for alkenyl modification. Next, it is mixed with quercetin-3-O-glucoside and TCS@ZIF-8 loaded with oridonin to obtain an antibacterial gel coating. Finally, the PDO mixed suture matrix is ​​impregnated in the antibacterial gel coating and prepared by ultraviolet light irradiation under a photoinitiator. The suture obtained by this application has the advantages of a smooth coating, highly efficient and durable antibacterial properties, high strength, good flexibility, low friction, and high operability.

The present invention relates to a dental / medical device that comprises poly(dioxanone) (PDO or PDS), preferably has an absorbent synthetic film exhibiting a color from white to grey, and is applied in the medical and dental fields. The dental / medical device may have stem cells and graphene used for inducing tissue reconstruction and / or inducing tissue regeneration of bone defects and other connective tissues (such as gingiva, skin, cartilage, cornea, etc.). Further, the present invention relates to the use of the device for the related applications described above and a method for manufacturing the device.

The present invention discloses a chitosan / polydioxanone composite hydrogel and its preparation method and application. The hydrogel is composed of chitosan with a deacetylation degree of ≥95% and a polydioxanone with a viscosity average molecular weight of 1×10 4 ~1×10 6 The invention discloses a chitosan / polydioxanone composite hydrogel, which is a cross-linked polymer swelling liquid formed by polydioxanone and prepared by repeated freeze-thaw treatment; wherein the amount of polydioxanone used is 1wt% to 18wt% of the weight of chitosan; the chitosan / polydioxanone composite hydrogel introduces polydioxanone molecular chains with excellent flexibility and mechanical properties into a chitosan hydrogel with a network structure to form a hydrogel with a network interpenetrating structure, thereby greatly improving the mechanical strength of the chitosan hydrogel; at the same time, the hydrogel has good degradability and biocompatibility, and its good biocompatibility enables it to be used in tissue engineering; in addition, the preparation method of the hydrogel is simple and the conditions are easy to control, and it has broad application prospects in the biomedical field.

The invention discloses an absorbable ligature clip with excellent mechanical properties and a preparation method of the absorbable ligature clip, and belongs to the technical field of absorbable materials and application. The absorbable ligature clip is of a double-layer structure made of different materials and comprises an inner-layer clip body and an outer-layer clip body, the inner-layer clip body is made of a mixture of a glycolide trimethylene carbonate block copolymer (PGA-TMC) and polyglycolide (PGA), and the outer-layer clip body is made of poly (p-dioxo-cyclohexanone) (PPDO); and the outer-layer clamp completely wraps the inner-layer clamp. And the glycolide trimethylene carbonate block copolymer (PGA-TMC) in the inner layer clamp accounts for 10 to 30 percent of the weight of the inner layer clamp. According to the invention, the mixed material of PGA-TMC and PGA is adopted in the inner layer clip, so that the overall rigidity of the ligature clip is reduced to a certain extent, and the mechanical maintenance time is prolonged.

The application provides a fiber membrane with poly-p-dioxanone as a base material and a preparation method thereof, and relates to the technical field of engineering tissue materials. The fiber membrane with poly-p-dioxanone as a base material comprises: an outer dense layer of PPDO material, and an inner layer of PPDO material formed by electrospinning on the outer dense layer; and the preparation method comprises the following steps: S10, PPDO is mixed with an organic solvent to prepare a PPDO solution a, the PPDO solution a is used for multiple times of film laying, and a PPDO base film is prepared through drying; S20, PPDO is mixed with an organic solvent to prepare a PPDO electrospinning solution c; and S30, electrospinning is performed on the PPDO base film by using the electrospinning solution c, so that the fiber membrane with poly-p-dioxanone as a base material is prepared; and the application can positively regulate intracranial cell behavior, shorten a degradation cycle, and accelerate the recovery process of a patient.

The present invention relates to electrospun multilayer tubes or wraps for the protection or bridging of damaged nerves, said tubes or wraps comprising an electrospun isolating outer layer and an active inner layer, said electrospun isolating outer layer comprising at least one polymer selected from the group consisting of polycaprolactone, polylactide, polyglycolide, polytrimethylene carbonate, polydioxanone, polyethylene glycol, polyurethane, copolymers or mixtures thereof, said active inner layer comprising at least one electrically conductive compound and / or at least one ionically conductive compound and / or at least one peptide or protein to stimulate nerve growth. Furthermore, the present invention relates to a method for the manufacture of such tubes or wraps and their use for the protection or bridging of nerves or for the stimulation of nerve growth and cell proliferation.

A polymer composite alloy for orthopedic implants includes a magnesium alloy coated with a polymer composite. The polymer composite can be polydioxanone. Alternatively, the polymer composite can be polyglyconate. Implants manufactured from the alloy composite are also provided. In an exemplary embodiment, the implant includes at least one through passage from one side of the implant to a distal side of implant.

The present invention relates to an injectable biomaterial consisting of particles of a collagen inducer and a composition comprising at least two crosslinked hyaluronic acids in a mixture. It also relates to a biomaterial according to the invention, characterised in that the collagen inducer is chosen from the polyhydroxyalkanoates (PHA), hydroxyapatites, polycaprolactones, polylactic or polyglycolic acids, polydioxanone, poly(trimethylene carbonates) (PTMC) and / or polysaccharides and derivatives thereof, such as dextranomer in isolated form or in the form of copolymers and / or mixtures in particulate form.

A method of preparing an implantable biomaterial includes combining a polymer comprising polydioxanone with a neuro-regenerative agent or an immunosuppressive agent comprising at least one immunophilin ligand, and melting the polymer. The method further includes extruding the combined polymer and the neuro-regenerative agent or immunosuppressive agent to form the implantable biomaterial.

Disclosed herein are a biodegradable polymer microparticle for a filler, a freeze-dried body including the same, a manufacturing method thereof, and filler injection including the freeze-dried body. The freeze-dried body includes hydrophilic surface-treated biodegradable polymer microparticle and a biocompatible carrier, wherein the hydrophilic surface-treated biodegradable polymer microparticle has an average particle diameter (D50) of 20 to 50 μm and is polydioxanone which has a carboxyl group on the surface thereof. The hydrophilic surface-treated biodegradable polymer microparticle is a plasma surface-treated product or a base surface-treated product using discharge of the biodegradable polymer microparticle. The content of the biocompatible carrier is 1 to 5 parts by weight based on 100 parts by weight of the freeze-dried body.

The present disclosure provides an absorbable biomedical polymer material, a ligating clip, and a method for preparing a ligating clip. In the present disclosure, the absorbable biomedical polymer material is composed of a first polymer and a second polymer, the first polymer consists of 50 wt % to 100 wt % poly-L-lactide and 0 wt % to 50 wt % polyglycolide, and the second polymer is polydioxanone. The absorbable biomedical polymer material has appropriate rigidity and toughness, and may be applied to prepare a medical device such as a ligating clip. The absorbable ligating clip has appropriate rigidity and toughness, especially when it contains 2.5 wt % to 40 wt % of the first polymer, facilitating piercing through a fascia and resisting plastic deformation at a bending point. Finally, the present disclosure further provides some structural forms of the ligating clip and the method for preparing the ligating clip.

This invention provides an antibacterial suture based on PDO and its preparation method. The preparation method involves taking polydioxanone (PDO) sutures, performing barbed or herringbone molding to obtain sutures with barbed or herringbone structures on the surface, followed by freeze-setting and plasma surface pretreatment. The plasma-pretreated sutures are then placed in a supercritical reactor with a supercritical CO2-antibacterial agent fluid system to obtain sutures coated with antibacterial agent. This invention overcomes the technical bottlenecks of traditional impregnation, spraying, and steam methods in the preparation of antibacterial coatings. By utilizing the high permeability of supercritical fluids and the synergistic effect of freezing, combined with plasma surface modification and freeze crystallization processes, the adhesion between the antibacterial coating and the PDO substrate is significantly improved, preventing coating peeling during use and extending the antibacterial period. Simultaneously, it achieves uniform coverage of the antibacterial agent on complex structural surfaces such as barbs and herringbone patterns, as well as deep within grooves, ensuring the consistency and stability of product performance.