83 results about "Polydioxanone" patented technology

A new embolic agent, bioabsorbable polymeric material (BPM) is incorporated to a Guglielmi detachable coil (GDC) to improve long-term anatomic results in the endovascular treatment of intracranial aneurysms. The embolic agent, comprised at least in part of at least one biocompatible and bioabsorbable polymer and growth factors, is carried by hybrid bioactive coils and is used to accelerate histopathologic transformation of unorganized clot into fibrous connective tissue in experimental aneurysms. An endovascular cellular manipulation and inflammatory response are elicited from implantation in a vascular compartment or any intraluminal location. Thrombogenicity of the biocompatible and bioabsorbable polymer is controlled by the composition of the polymer. The coil further is comprised at least in part of a growth factor or more particularly a vascular endothelial growth factor, a basic fibroblast growth factor or other growth factors. The biocompatible and bioabsorbable polymer is in the illustrated embodiment at least one polymer selected from the group consisting of polyglycolic acid, poly~glycolic acid/poly-L-lactic acid copolymers, polycaprolactive, polyhydroxybutyrate/hydroxyvalerate copolymers, poly-L-lactide. Polydioxanone, polycarbonates, and polyanhydrides.

A surgical fastener configured to close an opening in tissue is provided. The surgical fastener includes a base defining a central axis at least one pair of legs extending from the base. Each of the legs includes a base portion and a tissue engaging portion. When in a first position, each of the tissue engaging portions is arranged to define an insertion direction and when in a second position, each of the tissue engaging portions extends inward towards the central axis. The surgical fastener is at least partially formed from a shape memory material including a combination of Polydioxanone and Poly(L-lactide) or a combination of Trimethylene Carbonate and Poly(L-lactide). The pair of legs are configured to move from the first position to the second position upon activation of the shape memory material.

The present invention is directed to a reinforced absorbable hemostat comprising at least one hemostatic agent in a single layer of nonwoven synthetic fabric having a mixture of compressed fiber staples of a polyglycolide/polylactide copolymer and a polydioxanone.

Methods and compositions for use in tissue volume replacement are provided. The present invention comprises compositions comprising a combination of materials, comprising preferably a solid polymer particle phase and a gel phase, and also comprises single phase compositions. More particularly, preferred embodiments comprise a solid polymer particle phase made of materials comprising Gore-Tex (micronized e-PTFE), PDS II (polydioxanone, a monofilament), NUROLON (a long chain aliphatic polymer Nylon 6 or Nylon 6,6) ETHILON (a long chain aliphatic polymer Nylon 6 and Nylon 6,6), PROLENE (Polypropylene, isotactic crystalline stereoisomer of polypropylene, a synthetic linear polyolefin.), VICRYL (copolymer made from 90% glycolide and 10% L-lactide), silk, MONACRYL (poly ε-caprolactone.), polylactide, polyglycolide, poly lactide-co-glycolide, and BIOPOL (polyhydroxyvalerate), MEDPOR (biocompatible (micronized) polyethylene), BIOGLASS (bioactive glass particulate), NOVABONE and NOVABONE-CM, and the gel phase comprises polyvinylpyrrolidone (PVP). Preferred single phase compositions comprise PVP. Methods of the present invention comprising injection of such compositions for tissue augmentation.

Disclosed is a biodegradable sheet comprising at least one layer which is a direct contact layer, intended to successfully contact materials, such as liquids, while maintaining the mechanical properties of the sheet and to extend the biodegradable sheet shelf life. The direct contact layer may comprise a hydrophobic polymer selected from poly(epsilon-caprolactone) (PCL) polyhydroxybutyrate (PHB), Polydioxanone (PDO) polyglycolic acid (PGA), polybutylene succinate (PBS), polybutylene succinate adipate (PBS A), poly lactic acid (PL A), polybutylene adipate terphtalate (PBAT), polyhydroxyalkanoates (PHA), such as polyhydroxybutyrates (PHB), polyhydroxyvalerates (PHV), and polyhydroxybutyrate-hydroxyvalerate copolymers (PHBV) or any mixture thereof. The biodegradable sheet may further comprise surface treated nanoclay particles, PVOH grafted with a crosslinker and PBS or PBS A The biodegradable sheet may further include at least one metalized, biodegradable, laminate layer.

The invention discloses a method for improving the hydrophilia and flexibility of a polypeptide membrane through polydioxanone and polyethylene glycol. The method includes the following steps that firstly, carboxyl-terminated polydioxanone monododecyl ether, a solution, a condensing agent and a polypeptide homopolymer are added in a drying reactor for reaction for 3-4 days, and a polypeptide-polydioxanone segmented copolymer is obtained; secondly, carboxyl-terminated polydioxanone monododecyl ether carboxyl, a solution, a condensing agent and amidogen-terminated ethylene glycol monomethyl ether are added in the drying reactor for reaction for 2-3 days, and a polyethylene glycol-polydioxanone segmented copolymer is obtained; thirdly, the polypeptide-polydioxanone segmented copolymer, the polyethylene glycol-polydioxanone segmented copolymer and a solvent are added in the drying reactor to be mixed for 40-50 minutes, then tape casting is used for forming the membrane, drying is conducted, and the target object of the method is obtained. The method is simple in preparation technology, and the hydrophilia and flexibility of the obtained modified membrane are greatly improved.

A method of making a composite prosthetic device, such as a hernia repair device, includes providing a support layer, juxtaposing a layer of an absorbable material with the support layer, and disposing an absorbable adhesive between the support layer and the layer of an absorbable material. The method includes heating the layers for melting the absorbable adhesive so as to bond the support layer with the layer of the absorbable material. Before the heating step, the moisture content of at least one of the layers is increased for improving thermal conductivity between the layers so as to enhance the strength of the bonds formed between the layers. The moisture content may be increased by exposing at least one of the layers to an environment having elevated relative humidity. In one embodiment, the support layer is polypropylene mesh, the layer of the absorbable material is oxidized regenerated cellulose, and the absorbable adhesive is polydioxanone.

The invention relates to a medicine carrying nanofiber membrane and preparation and application methods thereof. The medicine carrying nanofiber membrane is composed of polylactic acid-hydroxyacetic acid copolymer fiber, polydioxanone fiber and medicines, wherein the medicines are dispersed inside the polylactic acid-hydroxyacetic acid copolymer fiber. The preparation method of the medicine carrying nanofiber membrane comprises (1) mixing the medicines and polylactic acid-hydroxyacetic acid copolymer with solvent and then mixing polydioxanone with solvent to obtain two mixed solutions; (2) independently loading the two mixed solutions and performing electrostatic spinning with multi-spinneret electrostatic spinning equipment to obtain the medicine carrying nanofiber membrane. The obtainedmedicine carrying nanofiber membrane is prepared through electrostatic spinning and is stable in property, high in porosity and similar to extracellular matrices, and when applied to postoperative stumps, can be extracted without secondary surgery, be degradable in vivo and achieve linear release of the medicines.

The invention discloses a nano-hydroxyapatite-modified polyurethane urea bone repair material and a preparation method thereof. The preparation method comprises the following steps: adding nano-hydroxyapatite into a dihydroxy-terminal polydioxanone solution, uniformly dispersing and then heating; adding a diisocyanate chain extender containing a ureido structure and carrying out chain extension reaction to obtain a dual-terminal isocyanate prepolymer; carrying out self-crosslinking reaction on the dual-terminal isocyanate prepolymer and polyatomic alcohol, removing a solvent and carrying out vacuum drying at normal temperature to obtain the nano-hydroxyapatite-modified polyurethane urea bone repair material, wherein the chain extension reaction is a chemical reaction that hydroxyl reacts with isocyanato to generate a mephenesin carbamate group. According to the method, a polyurethane-urea high polymer material is integrated with nano-hydroxyapatite with high biocompatibility to obtaina framework material with high porosity and proper aperture size; and the obtained bone repair material has the advantages of controllable degradation performance, good repair effect, high mechanicalproperty, high biocompatibility, absorbable degradation product and the like.

The invention relates to a tear drainage reconstruction system that can be regularly degraded. The reconstruction system is made by adopting polydioxanone (PDO) that is a degradable polymeric biomaterial. The system comprises an upper lacrimal duct part, a lower lacrimal dust part, a main lacrimal duct, a concave dacryocyst part and a nasolacrimal duct part. The system has good flexibility, certain elasticity, extensibility, breaking strength and compression strength performance and is a lamella micro-porous tubular structure that integrates stable nasolacrimal duct supporting function, 'tears pump' function, dacryocyst drainage function, 'drug control-release' function, the function of accelerating the fade-away of chronic inflammation of a lacrimal duct and the repairing function of mucous membrane injury of the lacrimal duct together. The reconstruction system has the advantages that an implanting method is a simple and convenient, the fixation in the lacrimal duct is the stable and reliable and the iatrogenic lacrimal duct injury can not appear, the regular degradation can be realized without secondary take-out and the reconstruction system is suitable for various lacrimal duct obstruction diseases and has high curative ratio of the lacrimal duct obstruction, especially, the reconstruction system has the stable and reliable medium-to-long term effect. The tears drainage reconstruction system currently is the only perfect material for high-degree lacrimal duct reconstruction that combines the physiological drainage of the tears with the pathological mechanism of lacrimal injury repair.

The invention provides an absorbable and knotting-free surgical suture capable of continuously resisting infection and used for thoracic surgery department. The absorbable and knotting-free surgical suture is composed of a PPDO (polydioxanone) fiber core located at the inner part, a compound drug-loading layer located in a middle layer and a collagen layer located on the outermost layer, wherein aplurality of tapered lug bosses are uniformly distributed on the compound drug-loading layer; the tapered lug bosses and the compound drug-loading layer are integrally molded; each tapered lug boss is composed of an inclined plane and a tabletop; the compound drug-loading layer is prepared from konjac glucomannan, quatemary ammonium salt chitosan, hyaluronic acid and genipin. The surgical sutureprepared by the invention does not need to be knotted in a surgery suturing process, can smoothly pass through muscle, does not easily slip off and has good biocompatibility; the absorbable and knotting-free surgical suture has a slow-release and antibacterial effect; after the absorbable and knotting-free surgical suture is degraded in a body, a product is discharged out of the body through metabolism, so that the absorbable and knotting-free surgical suture has no dangers and no toxic side effect.

The invention discloses a starch acetate-polydioxanone graft copolymer/inorganic particulate nano composite material which is prepared from a starch acetate-polydioxanone graft copolymer base material and nanometer inorganic particulates, wherein the weight ratio of starch acetate to graft copolymers is 1 to 40:100, and the weight ratio of the nanometer inorganic particulates to the starch acetate-polydioxanone graft copolymers is 0.5 to 10:100. The invention also discloses a preparation method of the starch acetate-polydioxanone graft copolymer/inorganic particulate nano composite material. Because the starch acetate and the nanometer inorganic particulates are introduced into the copolymer, the production cost is reduced, the thermal property, the mechanical property and the biodegradation rate of the polydioxanone are increased, and the preparation method has lower requirements for a monomer and a reaction condition and has simple operation, high production efficiency and no environment pollution.