8 results about "Polydioxanone" patented technology

The invention discloses a chemical indicator card for monitoring low-temperature steam formaldehyde sterilization, which belongs to the technical field of medical treatment and public health sterilization monitoring, and is composed of a Tyvek paper carrier and chemical indicator ink mixed by multiple chemicals, and the carrier has the length of 70.4 + / -1mm and the width of 8.8 + / -0.5 mm; the indicating ink can generate controllable color change according to the concentration, temperature and time of formaldehyde sterilization by adjusting the component proportion; the indicator card is matched with a semicircular loading box made of an ABS (Acrylonitrile Butadiene Styrene) material, a polytetrafluoroethylene tube with a specific size is arranged in the box, when the color is successfully changed, 0.9 ml of hydrogen peroxide is injected, and sterilization is carried out for 210 seconds, and when the color is failed, 0.6 ml of hydrogen peroxide is injected at the same temperature at the same time. The indicator card is simple in structure and convenient to use, adapts to PCD scenes, fills up related gaps in China, improves the sterilization monitoring accuracy and provides guarantee for sterilization of lumen type instruments.

The present invention relates to a dental / medical device consisting of an absorbable synthetic membrane, preferably white to gray in color, comprising poly(dioxanone) and optionally graphene and stem cells, to be used in guided tissue reconstruction and / or regeneration of bone defects and other connective tissues (gum, skin, cartilage or cornea, for example). Furthermore, the present invention relates to the use of said device for the above-related applications and to the process of preparing said device.

The present invention relates to an electrospun multilayer tube or wrap for the protection or bridging of damaged nerves, comprising an electrospun isolating outer layer and at least one electrospun inner layer, the electrospun isolating outer layer comprising at least one polymer selected from the group consisting of polycaprolactone, polylactide, polyglycolide, polytrimethylene carbonate, polydioxanone, polyethylene glycol, polyurethane, copolymers thereof or mixtures thereof, the at least one electrospun inner layer comprising an agent capable of forming a covalent bond with proteins and peptides, the agent comprising at least one group selected from the group consisting of N-hydroxysuccinimide, maleimide, thio-NHS, biotin-NHS, carboxylic acid or aldehyde. Furthermore, the present invention relates to a method of manufacturing such a tube or wrap and to their use for the protection or bridging of nerves or for stimulating nerve growth and cell proliferation.

The application provides a fiber membrane with poly-p-dioxanone as a base material and a preparation method thereof, and relates to the technical field of engineering tissue materials. The fiber membrane with poly-p-dioxanone as a base material comprises: an outer dense layer of PPDO material, and an inner layer of PPDO material formed by electrospinning on the outer dense layer; and the preparation method comprises the following steps: S10, PPDO is mixed with an organic solvent to prepare a PPDO solution a, the PPDO solution a is used for multiple times of film laying, and a PPDO base film is prepared through drying; S20, PPDO is mixed with an organic solvent to prepare a PPDO electrospinning solution c; and S30, electrospinning is performed on the PPDO base film by using the electrospinning solution c, so that the fiber membrane with poly-p-dioxanone as a base material is prepared; and the application can positively regulate intracranial cell behavior, shorten a degradation cycle, and accelerate the recovery process of a patient.

The present invention relates to electrospun multilayer tubes or wraps for the protection or bridging of damaged nerves, said tubes or wraps comprising an electrospun isolating outer layer and an active inner layer, said electrospun isolating outer layer comprising at least one polymer selected from the group consisting of polycaprolactone, polylactide, polyglycolide, polytrimethylene carbonate, polydioxanone, polyethylene glycol, polyurethane, copolymers or mixtures thereof, said active inner layer comprising at least one electrically conductive compound and / or at least one ionically conductive compound and / or at least one peptide or protein to stimulate nerve growth. Furthermore, the present invention relates to a method for the manufacture of such tubes or wraps and their use for the protection or bridging of nerves or for the stimulation of nerve growth and cell proliferation.

A method of preparing an implantable biomaterial includes combining a polymer comprising polydioxanone with a neuro-regenerative agent or an immunosuppressive agent comprising at least one immunophilin ligand, and melting the polymer. The method further includes extruding the combined polymer and the neuro-regenerative agent or immunosuppressive agent to form the implantable biomaterial.

Disclosed herein are a biodegradable polymer microparticle for a filler, a freeze-dried body including the same, a manufacturing method thereof, and filler injection including the freeze-dried body. The freeze-dried body includes hydrophilic surface-treated biodegradable polymer microparticle and a biocompatible carrier, wherein the hydrophilic surface-treated biodegradable polymer microparticle has an average particle diameter (D50) of 20 to 50 μm and is polydioxanone which has a carboxyl group on the surface thereof. The hydrophilic surface-treated biodegradable polymer microparticle is a plasma surface-treated product or a base surface-treated product using discharge of the biodegradable polymer microparticle. The content of the biocompatible carrier is 1 to 5 parts by weight based on 100 parts by weight of the freeze-dried body.

This invention provides an antibacterial suture based on PDO and its preparation method. The preparation method involves taking polydioxanone (PDO) sutures, performing barbed or herringbone molding to obtain sutures with barbed or herringbone structures on the surface, followed by freeze-setting and plasma surface pretreatment. The plasma-pretreated sutures are then placed in a supercritical reactor with a supercritical CO2-antibacterial agent fluid system to obtain sutures coated with antibacterial agent. This invention overcomes the technical bottlenecks of traditional impregnation, spraying, and steam methods in the preparation of antibacterial coatings. By utilizing the high permeability of supercritical fluids and the synergistic effect of freezing, combined with plasma surface modification and freeze crystallization processes, the adhesion between the antibacterial coating and the PDO substrate is significantly improved, preventing coating peeling during use and extending the antibacterial period. Simultaneously, it achieves uniform coverage of the antibacterial agent on complex structural surfaces such as barbs and herringbone patterns, as well as deep within grooves, ensuring the consistency and stability of product performance.