109 results about "Genipin" patented technology

The invention belongs to the field of medical instrument coloring agents, and provides a natural anthocyanin endoscope coloring agent. According to the invention, the innovative design of combining a ternary color-stabilizing compound formed by anthocyanin, a co-chromophore and hydroxypropyl beta cyclodextrin with a chitosan sodium alginate polysaccharide system and a composite buffer system is adopted, and the viscosity is controlled to be 200-320 millisecond, the particle size of spray droplets is 40-60 microns, and the thickness of a thin film is 10-30 microns through specific molar ratio compatibility and a genipin crosslinking technology. Through accurate regulation and control, the excellent performance that a double-network thin layer is formed under the calcium ion environment that the absorbance retention rate at 520 nanometers is not lower than 90% and the elution rate is not lower than 90% under the irradiation of hundred thousand lux white light is achieved, the technical problems that a traditional endoscope coloring agent is poor in safety, low in stability and insufficient in mucous membrane contrast ratio are solved, and the wide clinical application value is achieved.

The embodiment of the invention relates to the technical field of electrolytes, and provides a preparation method of a hydrogel electrolyte, the hydrogel electrolyte and a zinc ion battery, and the preparation method comprises the following steps: preparing a chitosan aqueous solution with a first preset concentration; the preparation method comprises the following steps: adding a certain amount of genipin into a chitosan aqueous solution, so that the genipin and chitosan in the chitosan aqueous solution are crosslinked at a first preset temperature; coating the cross-linked slurry on a substrate of a preset material, and drying and demolding at a second preset temperature to obtain a hydrogel electrolyte dry film; and soaking the hydrogel electrolyte dry film in a liquid electrolyte with a second preset concentration to absorb the liquid until the liquid is saturated, thereby obtaining the hydrogel electrolyte. Chitosan and genipin used in the embodiment of the invention are natural substances and are non-toxic and harmless, so that the prepared hydrogel electrolyte belongs to an environment-friendly electrolyte material, the problem that a cross-linking agent in a traditional electrolyte material is relatively high in toxicity is effectively avoided, and the problem of side reaction caused by using water as an electrolyte solvent is also avoided.

The invention relates to the technical field of functional food and biological medicine, in particular to a modified pseudo-ginseng exosome and an intestinal conditioning gel composition and application thereof. According to the gel beverage, an exosome derived from panax notoginseng callus cultured in a laboratory is used as a core active component, is modified through phosphatidylserine-aminated pectin-genipin and is embedded into a hydrogel matrix composed of carboxymethyl chitosan and sodium alginate, so that the exosome is protected from being degraded in the stomach, and the activity of the exosome in the stomach is improved. The exosome can be effectively released under the intestinal pH and flora environment, so that the targeted delivery of the intestinal tract is realized, and the preparation method is suitable for improving the intestinal inflammation and maintaining the intestinal health. The invention can effectively solve the technical problems of uncontrollable raw material quality and safety, low oral delivery stability and active ingredient availability and poor medication compliance of the existing plant exosome.

A natural aldehyde-functionalized all-biomass aerogel and a preparation method thereof, the method comprises: (1) dispersing chitosan in a starch-like fiber solution and stirring to obtain a uniform mixed solution; (2) adding genipin as a crosslinking agent to the mixed solution obtained in step (1), heating and stirring for a period of time to obtain an aerogel precursor solution, and allowing the same to stand to undergo crosslinking to obtain a hydrogel; (3) freezing the hydrogel obtained in step (2), and then freeze-drying to obtain an aerogel; (4) soaking the aerogel obtained in step (3) in a natural aldehyde solution for graft modification, then removing and rinsing, and subsequently drying to obtain the aldehyde-functionalized aerogel.

The invention discloses a biochar-reinforced hydrogel slow-release fertilizer and a preparation method thereof, and relates to the technical field of fertilizers. Comprising the following steps: S1, preparing sorghum straw biochar; s2, adding the sorghum straw biochar and a potassium nitrate and ammonium dihydrogen phosphate solution into a polymer monomer mixed solution to obtain a biochar gel mixed solution; s3, adding the genipin solution into the biochar gel mixed solution, stirring, performing ultrasonic treatment, freezing and unfreezing to obtain the biochar reinforced hydrogel slow-release fertilizer. Aiming at the technical defects of the hydrogel slow-release fertilizer, the performance of the hydrogel slow-release fertilizer is modified and enhanced by utilizing the biochar, and the biochar-enhanced hydrogel slow-release fertilizer is formed. The preparation method is simple in process and convenient to operate, the raw materials are cheap and easy to obtain, the cost is low, and the prepared biochar reinforced hydrogel slow-release fertilizer has the advantages of good slow-release performance, high water retention capacity and environmental stability, and is of great significance in popularization and application of the hydrogel slow-release fertilizer.

The invention discloses a microbial soil conditioner and a preparation method thereof, and relates to the technical field of soil improvement. The method comprises the following steps: culturing heavy metal-resistant chlorella and aspergillus niger to obtain a mixed bacterial suspension, combining the mixed bacterial suspension with a composite chelating modifier prepared by reacting chitosan quaternary ammonium salt, ethylenediamine tetraacetic acid and epichlorohydrin, carrying out crosslinking by using genipin to obtain a functional microbial agent, and carrying out pyrolysis and acid oxidation on corn straws as a raw material to obtain the heavy metal-resistant chlorella modified functional microbial agent. The preparation method comprises the following steps: preparing a nano zero-valent iron-biochar composite material, reducing and loading ferrous ions through sodium borohydride, preparing the nano zero-valent iron-biochar composite material, mixing the nano zero-valent iron-biochar composite material with zeolite, bentonite and a silane coupling agent, carrying out spray drying to prepare a porous carrier substance, and finally stirring and mixing an organic fertilizer complex microbial inoculant, the functional microbial inoculant and the carrier substance, and aging to prepare the soil conditioner. The prepared conditioner has a good remediation effect on soil heavy metal pollution.

The invention belongs to the field of polymer chemistry and biological medicine materials, and relates to application of a polymer polysaccharide slow-release carrier in medicinal and edible components and a preparation method of the polymer polysaccharide slow-release carrier. The carrier is composed of phytic acid-genipin cross-linked modified chitosan, tannic acid, sodium lactate, glycerin, vitamin E acetate, sodium alginate and deionized water. The phytic acid-genipin cross-linked modified chitosan is prepared by reacting chitosan with phytic acid and genipin, and has reversible cross-linking and polydentate coordination properties; the tannic acid and the modified chitosan can form a multi-point hydrogen bond and esterification network. The carrier is prepared through sol-gel forming or spray drying, is stable in structure, good in dispersity, high in drug loading capacity, stable in an acid environment and controllable in release under a neutral condition, remarkably improves the slow release performance and bioavailability of medicinal and edible components, and is suitable for functional food and drug delivery systems.

The invention discloses an eucommia ulmoides wood controllable carbonization-gradient hooping phenol fragrance barrel for white spirit, and belongs to the technical field of wine brewing equipment. In order to solve the problems that a traditional oak barrel is high in cost, an eucommia wood barrel is incomplete in pretreatment, uneven in structural stress and poor in flavor controllability, eucommia wood with the tree age of 18-22 years is adopted as a base material, and pretreatment of segmented steaming, microwave degreasing and gradient drying is conducted; the barrel body is provided with a controllable carbonization modification layer, a 304 stainless steel gradient hoop enhancement layer, a triple-closing sealing layer and a flow guide groove functional layer, and a composite fragrant juice activation process is matched. The barrel can dissolve active ingredients of eucommia ulmoides such as geniposide and aucubin, the leakage rate is smaller than or equal to 0.05%, the content of guaiacol is increased by 42 times compared with a traditional pottery jar, the cost is reduced by 60% compared with an imported oak barrel, and the barrel is suitable for high-quality ageing of Chinese high-degree white spirit.

The present invention belongs to the technical field of home furnishings, and provides a material for preparing polymeric air fibers, and a preparation method therefor and the use thereof. The preparation method comprises: preparing a ceramic powder doped with antibacterial TiO2 / ZnO / ZrO2; depositing magnetic ferroferric oxide thereon; after the surface is modified by tannic acid, adding same to a water-soluble chitosan solution; immersing same in a TPEE air fiber membrane prepared by means of melt-blowing; uniformly adding a genipin solution dropwise; heating and reacting same; and taking out the membrane, washing and drying same to obtain a material for preparing polymeric air fibers. The TPEE air fiber membrane prepared in the present invention has good mechanical properties, and the modified ceramic powder is uniformly dispersed in the TPEE air fiber membrane, achieving good antibacterial, environmental protection, immunity regulation, magnetic therapy, far-infrared heating and other effects, such that the prepared material for preparing polymeric air fibers has better overall performance. Thus, the material is a good mattress support material, and has broad application prospects.

The invention belongs to the technical field of medical dressings, and provides a hydrocolloid acne patch and a preparation method thereof. According to the invention, beta-cyclodextrin functionalized gelatin and adamantane functionalized hyaluronic acid are subjected to inclusion interaction to form a reversible cross-linked network, and hydroxypropyl trimethyl ammonium chloride chitosan and sodium carboxymethyl cellulose are subjected to electrostatic interaction to form a polyelectrolyte cross-linked network; the genipin is combined with a primary amine group amido bond to form a triple cross-linked network structure design of a covalent cross-linked network, and antibacterial components such as a gamma-cyclodextrin-salicylic acid inclusion compound are loaded, so that the excellent properties that the self-healing recovery rate is 90-95%, the water vapor transmission rate is 500-900g. M <-2 >. 24h <-1 >, and the peel strength is greater than or equal to 1.0 N / 25mm are realized; the technical problem that an existing hydrocolloid acne patch is insufficient in antibacterial persistence and self-healing and repairing capacity is solved, and wide application value is achieved.

This invention relates to the field of down fabric technology, specifically to a mite-proof and antibacterial composite down and its preparation method. The mite-proof and antibacterial composite down includes two outer fabric layers, two inner down-proof fabric layers, two nanocellulose / chitosan composite layers, and down filling. The nanocellulose / chitosan composite layers are prepared from the following components: aqueous polyurethane emulsion, nanocellulose, chitosan, chitosan-modified wood vinegar powder, natural genipin, and a dispersant. Chitosan is added in the form of an acetate-sodium acetate buffer solution with a pH of 4.0–4.8. This invention, through the synergistic effect of chitosan-modified wood vinegar powder and nanocellulose, combined with an aqueous polyurethane matrix, can simultaneously achieve high repellency, high antibacterial rate, and excellent wash resistance. Furthermore, the nanocellulose enhances the interfacial bonding strength of the nanocellulose / chitosan composite layer, significantly improving interlayer adhesion strength and down-proof performance.

The invention discloses a bio-based double-core high-elastic jean fabric, and particularly relates to the field of bio-based fiber materials. Weft yarns of the fabric adopt bio-based double-core elastic twisted yarns as core yarns and covering yarns wrapped by cotton fibers, and warp yarns are pure cotton yarns. The preparation method comprises the steps that chitosan and zinc lignosulfonate are blended, spun and crosslinked, and elastic fiber A is prepared to serve as first core yarn; blending silk fibroin with epoxidized natural rubber latex containing a vulcanizing agent, performing wet spinning, gelation and steam vulcanization, and performing genipin cross-linking to obtain an elastic fiber B as a second core yarn; the two kinds of core yarn are doubled and entangled through an air network to obtain double-core plied yarn; taking the yarn as core yarn, wrapping the yarn with cotton roving, and preparing core-spun weft yarn through a siro spinning process; and finally, weaving the fabric and pure cotton warp yarns into gray fabric, and performing desizing, dyeing, sizing and water washing treatment to obtain the final fabric. The fabric is excellent in elasticity, high in bio-based content, comfortable to wear and environmentally friendly.

The invention discloses a gastric mucosa repairing composition based on cuttlebone and oxhide gelatin and a preparation method of the gastric mucosa repairing composition. The gastric mucosa repairing composition comprises cuttlebone active components, modified oxhide gelatin and probiotics, the cuttlebone active component comprises nano-scale particles; the modified oxhide gelatin is a porous scaffold material subjected to genipin crosslinking treatment; the probiotics comprise lactobacillus reuteri and bifidobacterium. According to the application, through the compounding of the nanocrystallized cuttlebone active component, the genipin cross-linked and modified porous oxhide gelatin scaffold, the specific probiotics and the licorice total flavonoids, a multi-dimensional synergistic repair system is adopted, nano-calcium can quickly neutralize gastric acid and locally stop bleeding, cuttlebone polysaccharide and active peptide can up-regulate expression of growth factors such as EGF and VEGF, and the effect of stopping bleeding is achieved. Proliferation and migration of epithelial cells and fibroblasts are directly driven; the modified oxhide gelatin forms a stable bionic adhesive protective film, and the stable bionic adhesive protective film is used as a three-dimensional scaffold to guide cells to crawl.

The invention discloses an antibacterial emulsion for skin and a preparation method thereof, and belongs to the technical field of emulsion medicines. The antibacterial emulsion is prepared from the following raw materials in parts by weight: 3 to 5 parts by weight of modified chitosan, 10 to 20 parts by weight of cross-linked oxidized cyclodextrin inclusion compound, 0.1 to 0.15 part by weight of genipin, 60 to 70 parts by weight of water phase matrix and 10 to 15 parts by weight of oil phase matrix. The antibacterial emulsion prepared by the preparation method disclosed by the invention has a good antibacterial effect and a transdermal effect.

This invention relates to the field of biological hemostatic materials technology, specifically a biological hemostatic dressing, its preparation method, and its application. The dressing consists of a core layer, an intermediate layer, and a surface layer, forming a gradient pore structure through electrospinning and achieving gradient stabilization through genipin cryo-crosslinking. The preparation process includes raw material pretreatment, layered spinning, cryo-crosslinking, and post-treatment. It can rapidly activate coagulation, provide long-lasting antibacterial effects, and promote tissue regeneration, making it suitable for scenarios such as wound hemostasis and wound repair. Through the three-layer gradient structure and the material's dynamic response, it achieves a temporal adaptation of rapid coagulation during the hemostatic phase, antibacterial and anti-inflammatory effects during the inflammatory phase, and tissue regeneration during the proliferative phase, overcoming the functional limitations of single materials.

This invention provides a radiation-proof, antibacterial, and deodorizing fabric and its preparation method, belonging to the field of fabric preparation technology. This invention constructs a bio-crosslinking network using a chitosan / polyethylene glycol composite gel and the natural crosslinking agent genipin. Combined with a gradient pore design of an inner high-porosity bio-reservoir layer and an outer sparse porous radiation-proof functional layer, it achieves an integrated and stable bond between the radiation-proof coating and Bacillus subtilis spore capsules. The invention utilizes the biofilm densification formed by in-situ germination of spores and the dual antibacterial system of plant-derived antibacterial agents to avoid the risk of drug resistance. Simultaneously, a pore-forming agent is added to the coating solution to balance the density of the radiation-proof layer and the breathability of the biofilm growth. This solves the technical problems in existing technologies, such as the functional conflict between the density of the radiation-proof coating and the breathability of the antibacterial components, insufficient long-term stability, and the imbalance between function and practicality. It is suitable for daily protection, medical protection, special protection, and high-end civilian applications.

The invention belongs to the field of bio-based composite materials, and particularly relates to a bio-based film as well as a preparation method and application thereof. The bio-based film is of a double-layer composite structure and comprises an outer layer, the outer layer is formed by cross-linking chitosan and cellulose nanofibers through a cross-linking agent genipin and hydrophobic modification through caprylic acid, and a high-barrier transparent protective layer is formed; and the inner layer is formed by compounding thermoplastic starch and a hydrophobic deep-eutectic solvent consisting of thymol and octanoic acid, so that the heat sealing layer with antibacterial and antioxidant functions is formed.

The application discloses a kind of for hernia repair containing acellular dermis biological patch and preparation method thereof, belong to biomedical material field, raw material includes acellular porcine dermis layer matrix 90-110 parts, genipin 0.1-0.2 parts, EDC 0.8-2.5 parts, NHS 0.3-1 part, carboxymethyl chitosan 3-8 parts, sodium hyaluronate 1.5-4 parts, chondroitin sulfate 0.5-2 parts, glycerol 2-5 parts, modified zinc tannate nanocomposite 3-12 parts, effectively solve the problems that existing hernia repair patch anti-adhesion and tissue ingrowth is difficult to coordinate, support strength and degradation rate are not matched, foreign body exists in human tissue for a long time and leads to inflammation, by introducing anti-adhesion coating containing zinc tannate coordination nanocomposite and asymmetric double-sided structure, the patch realizes abdominal cavity side long-acting anti-adhesion, abdominal wall side rapid tissue integration and controllable degradation and mechanical support under low immunogenicity.

The invention discloses a gardenia blue pigment as well as a preparation method and application thereof, and the preparation method comprises the following steps: adding neutral amino acid or arginine with the molecular weight greater than 130 into a phosphate solution containing genipin, and reacting under the condition that the pH is 4-10 to obtain a reaction solution; the reaction solution is sequentially eluted through a macroporous resin chromatographic column, water and 30%-80% ethyl alcohol, a developed ethyl alcohol eluent is collected, vacuum concentration and drying are conducted, and the gardenia blue pigment is obtained. According to the method, the phosphate solution is adopted as a catalyst to catalyze the genipin to react with the preferable arginine and the specific neutral amino acid to synthesize the high-tone gardenia blue pigment, meanwhile, the reaction temperature and time are regulated and controlled, the quality of the gardenia blue pigment is improved, the characteristic lambda max of the visible spectrum of the gardenia blue pigment is not lower than 602 nm, and A610 / A585 is not lower than 1.0; the prepared high-tone gardenia blue pigment is safe and non-toxic, and can be applied as a coloring agent in the fields of food, cosmetics and pharmaceuticals.

The invention discloses an ultrasonic extraction method for optimizing geniposide in gardenia by a response surface method, and belongs to the field of extraction of active ingredients of traditional Chinese medicines. The ultrasonic extraction method for optimizing geniposide in fructus gardeniae through the response surface method comprises the following steps: shelling fructus gardeniae, and then crushing the fructus gardeniae to obtain fructus gardeniae powder; drawing a geniposide standard curve through a geniposide standard product; mixing the gardenia powder with an ethanol solution, and performing ultrasonic-assisted extraction to obtain geniposide; the extraction conditions are determined through a single factor test and a response surface test. According to the method, key influence factors (ethanol concentration, material-liquid ratio and ultrasonic time) are preliminarily determined through a single-factor test, interaction of the key influence factors is further analyzed by utilizing a response surface method, and extraction process parameters of geniposide are optimized. Test results show that the extraction process significantly improves the extraction rate of geniposide, and provides a reliable and convenient process scheme for efficient utilization of cape jasmine resources.

According to the radioactive hydrogel and the preparation method and application thereof and the radioactive tumor treatment application, chitosan serves as a matrix and is crosslinked with genipin to construct a three-dimensional network, and stable loading and slow release of radionuclides can be synchronously achieved; the self-antibacterial and adhesion characteristics of the patch can reduce the infection risk and ensure the fixation of the patch, so that a safe, effective and easy-to-operate local treatment platform is provided, the prepared patch can be directly placed on a tumor bed after resection in an operation, beta or alpha rays released by radionuclides accurately and continuously act on an area where tumor cells are most likely to remain, and the effect of treating the tumor cells is achieved. Different from traditional external radiation radiotherapy, the hydrogel can continuously release radiation with a low dosage rate. The mode has a stronger biological effect (such as inhibition of reproliferation) on tumor cells, the radiosensitivity difference of different cell periods and time phases can be overcome, the killing effect is more thorough, and chitosan is proved to have certain antibacterial activity, tumor cell growth inhibition activity and immunomodulatory activity. A synergistic effect can be generated with radionuclide, and a microenvironment which is not beneficial to survival and relapse of tumor cells is constructed together with the radionuclide.

The invention discloses a method for efficiently purifying gardenia blue pigment based on combination of ion exchange resin and an ultrafiltration membrane, and belongs to the technical field of natural pigment purification. The method comprises the following steps: adjusting the pH value of a gardenia blue pigment crude product solution to 5.0-7.0, pretreating, loading to anion exchange resin for adsorption, sequentially carrying out gradient elution by using 5% and 10% NaCl aqueous solutions, collecting pigment eluents with different molecular weight proportions, separating by using an ultrafiltration membrane with the molecular weight cut-off of 1000-4000 Da, and finally concentrating and drying. According to the method, efficient and specific removal of gardenoside, genipin and methanol is synergistically realized through charge selective adsorption and gradient elution of ion exchange resin in combination with precise screening of an ultrafiltration membrane, meanwhile, the pigment recovery rate is greater than 95%, the product impurity residue is low, the process is green, and the method is suitable for industrial production.

This invention discloses an antibacterial microcapsule of Artemisia argyi oil, its preparation method, and its application. The preparation method includes wall material solution preparation, fine emulsion preparation, coagulation reaction, cross-linking curing, and post-treatment. The wall material solution includes a gelatin aqueous solution and a gum arabic aqueous solution. Artemisia argyi oil and gelatin solution are mixed and homogenized under high pressure microfluidic jet to obtain a fine emulsion. Gum arabic solution is added to the fine emulsion for coagulation reaction. Genipin aqueous solution is added as a cross-linking agent after cooling. After cross-linking curing, the microcapsule is centrifuged, washed, and freeze-dried to obtain Artemisia argyi oil antibacterial microcapsule powder. The high-pressure microfluidic jet homogenization technology results in high encapsulation efficiency and uniform particle size of the microcapsules. The use of genipin improves the thermal stability of the microcapsules. This makes the release of the core material more gradual and prolonged, and the release kinetics are more in line with the Fick diffusion mechanism, enabling long-lasting antibacterial effects. The low temperature rise during the high-pressure microfluidic jet homogenization process helps protect the heat-sensitive active ingredients in Artemisia argyi oil.

The invention discloses dipeptide and curcumin molecule co-assembled nanoparticles as well as a preparation method and application thereof, and relates to the technical field of biological medicines and nano materials. The nano-particles are prepared by taking cationic diphenylalanine, genipin GNP and curcumin as raw materials through co-assembly by a'one-pot method '. Under an alkaline condition, amino of CDP and active dialdehyde formed by ring opening of GNP are subjected to a Schiff base reaction, a covalent cross-linked rigid skeleton is constructed, curcumin is efficiently entrapped through a hydrophobic effect and a pi-pi accumulation effect, and the entrapment efficiency can reach 90%. The obtained nanoparticles are regularly spherical and uniform in particle size, have positive charges on the surface, and have excellent anti-acid stability, pH response release characteristics and remarkable anti-tumor activity. The preparation method disclosed by the invention is simple, mild in condition and high in biological safety, and the obtained nanoparticles have a wide application prospect in an oral hydrophobic antitumor drug delivery system.

The invention provides a chlorine dioxide slow-release composition. The chlorine dioxide slow-release composition comprises a component A, a component B and a component C, the component A comprises sodium chlorite, a first high-molecular compound and water; the first high-molecular compound comprises one or more of polyvinyl alcohol, polyethylene glycol and polyacrylamide; the component B comprises organic acid, a second high-molecular compound and water; the second high-molecular compound comprises genipin or sodium alginate; the component C comprises a cross-linking agent and water, and the cross-linking agent is chlorate. In the sustained-release composition provided by the invention, the sodium chlorite is wrapped in the first high-molecular compound capable of forming the hydrogel, and then is mixed with the organic acid, the second high-molecular compound and the cross-linking agent to form a cross-linking product wrapping the organic acid, so that the sodium chlorite and the organic acid react along with degradation of the hydrogel and the cross-linking product; and chlorine dioxide gaseous molecules are slowly and continuously released, so that the antibacterial action period of a coating formed by the composition is prolonged.

A room temperature injectable thermo-responsive hydrogel comprises a P407 poloxamer base hydrogel, chitosan, 2-Hydroxypropyl ß-cyclodextrin. and genipin. The chitosan and genipin form an interpenetrating scaffold within the hydrogel in which the chitosan is crosslinked with genipin. Chemotherapeutic drugs can be added to the hydrogel singly or in combination in effective amounts without any loss of thermo-responsiveness in the hydrogel. Therapeutic use of the thermo-responsive hydrogel in the intratumoural treatment of solid cancer is also described.

The invention discloses a preparation method of an antibacterial polypropylene monofilament and the antibacterial polypropylene monofilament. Polypropylene monofilaments are pretreated, and the pretreated polypropylene monofilaments are immersed in an ethanol water solution of a silane coupling agent to react for set time; preparing a quaternized chitosan aqueous solution and a genipin aqueous solution, uniformly mixing the quaternized chitosan aqueous solution and the genipin aqueous solution to form a mixed solution, and immersing the reacted polypropylene monofilaments into the mixed solution for reaction; and immersing the polypropylene monofilament into an aqueous solution containing a zwitterionic monomer and an initiator for reaction. The zwitterionic polymer on the outer layer of the antibacterial polypropylene monofilament forms complexation through strong electrostatic interaction with quaternized chitosan, so that the zwitterionic polymer and the quaternized chitosan form a stable compound, and the hydration of the zwitterionic polymer forms a'hydration layer ', so that initial adhesion of protein and bacteria is effectively resisted; the quaternized chitosan on the inner layer is used for killing bacteria breaking through a defense line in a contact manner, and the quaternized chitosan and the quaternized chitosan cooperate with each other, so that the antibacterial efficiency is higher and more durable, and a biological membrane can be effectively prevented from being formed.

This invention discloses a near-infrared photoresponsive hydrogel, its preparation method, and its application in wound repair. The method includes the following steps: S1, modifying chitosan with 1,3-propanesulfonate lactone to prepare sulfonated chitosan; S2, mixing sulfonated chitosan solution, chitosan solution, genipin solution, and NaOH solution to prepare a hydrogel solution; S3, blending MXene, MOF, and the hydrogel solution to prepare a near-infrared photoresponsive hydrogel. The composite hydrogel provided by this invention utilizes the biomimetic structure and good biocompatibility of sulfonated chitosan, combined with the photothermal properties of MXene and the catalytic and ion-release characteristics of MOF, to achieve a dual function of broad-spectrum and highly effective antibacterial activity and multi-pathway promotion of skin tissue regeneration. This provides a novel integrated solution for the treatment of infected wounds, combining anti-infection, promotion of vascularization, and re-epithelialization.

The present application relates to a kind of seedling substrate and its preparation method, it relates to crop planting technical field, a kind of seedling substrate, including hydrogel microspheres and composite substrate component, the composite substrate component includes: peat, vermiculite, perlite, humic acid, zeolite powder, slow-release fertilizer particle;The composition of the hydrogel microspheres includes: soybean protein isolate, sodium carboxymethyl cellulose, naphthalene acetic acid, xanthan gum, genipin, chitosan, calcium chloride, bacillus subtilis bacterial agent;Its preparation process includes hydrogel microspheres preparation, premixing, initial mixing, final mixing step;The seedling substrate and its preparation method protected in the present application, utilize the porous loose structure formed by hydrogel microspheres, this porous structure makes microsphere only slightly expand after absorbing water, while guaranteeing water-retention capacity, guaranteeing ventilation performance, provide stable microenvironment for seedling growth, further improve crop seedling quality.