189 results about "Genipin" patented technology

The invention relates to the technical field of medical materials, and particularly discloses a biocompatible hydrogel microneedle nursing dressing and a preparation method thereof. A biocompatible hydrogel microneedle nursing dressing comprises a hydrogel substrate, microneedles regularly attached to the side, facing the skin, of the hydrogel substrate, and a breathable film layer attached to the side, back to the skin, of the hydrogel substrate. The micro-needle array tip area of the biocompatible hydrogel micro-needle nursing dressing provides rigid support through silk fibroin, it is ensured that a micro-needle can penetrate through the cuticle, the silk fibroin and hyaluronic acid are compounded through the middle-layer needle body transition area, the mechanical strength and the swelling property are balanced, the flexibility is improved through glycerinum, the needle body is prevented from being broken, and the biocompatibility is improved. The closed area of the top substrate adopts high-concentration hyaluronic acid to achieve rapid water absorption swelling and promote drug diffusion, polydopamine nanoparticles enhance antibacterial property and tissue adhesion, genipin crosslinking improves mechanical strength, and a sealing barrier is formed to prevent drug leakage.

A material for producing macromolecule air fibers, a preparation method, and an application thereof are provided. The material for producing macromolecule air fiber is prepared by preparation of doped antibacterial TiO2 / ZnO / ZrO2 ceramic powder, deposition of magnetic iron oxide, surface modification with tannic acid, addition of water-soluble chitosan solution, immersion in a spined TPEE air fiber membrane, uniform addition of Genipin solution, heating and reacting, membrane removal, washing, and drying. The TPEE air fiber membrane produced by the present disclosure has good mechanical properties, and modified ceramic powder is uniformly dispersed in the TPEE air fiber membrane, which plays a good role in antibacterial, environmental protection, immune regulation, magnetic therapy, far-infrared heating and other effects, rendering the material for producing macromolecule air fibers have better comprehensive performance and a good mattress support material with broad application prospects.

The invention belongs to the field of medical instrument coloring agents, and provides a natural anthocyanin endoscope coloring agent. According to the invention, the innovative design of combining a ternary color-stabilizing compound formed by anthocyanin, a co-chromophore and hydroxypropyl beta cyclodextrin with a chitosan sodium alginate polysaccharide system and a composite buffer system is adopted, and the viscosity is controlled to be 200-320 millisecond, the particle size of spray droplets is 40-60 microns, and the thickness of a thin film is 10-30 microns through specific molar ratio compatibility and a genipin crosslinking technology. Through accurate regulation and control, the excellent performance that a double-network thin layer is formed under the calcium ion environment that the absorbance retention rate at 520 nanometers is not lower than 90% and the elution rate is not lower than 90% under the irradiation of hundred thousand lux white light is achieved, the technical problems that a traditional endoscope coloring agent is poor in safety, low in stability and insufficient in mucous membrane contrast ratio are solved, and the wide clinical application value is achieved.

The embodiment of the invention relates to the technical field of electrolytes, and provides a preparation method of a hydrogel electrolyte, the hydrogel electrolyte and a zinc ion battery, and the preparation method comprises the following steps: preparing a chitosan aqueous solution with a first preset concentration; the preparation method comprises the following steps: adding a certain amount of genipin into a chitosan aqueous solution, so that the genipin and chitosan in the chitosan aqueous solution are crosslinked at a first preset temperature; coating the cross-linked slurry on a substrate of a preset material, and drying and demolding at a second preset temperature to obtain a hydrogel electrolyte dry film; and soaking the hydrogel electrolyte dry film in a liquid electrolyte with a second preset concentration to absorb the liquid until the liquid is saturated, thereby obtaining the hydrogel electrolyte. Chitosan and genipin used in the embodiment of the invention are natural substances and are non-toxic and harmless, so that the prepared hydrogel electrolyte belongs to an environment-friendly electrolyte material, the problem that a cross-linking agent in a traditional electrolyte material is relatively high in toxicity is effectively avoided, and the problem of side reaction caused by using water as an electrolyte solvent is also avoided.

The invention relates to the technical field of functional food and biological medicine, in particular to a modified pseudo-ginseng exosome and an intestinal conditioning gel composition and application thereof. According to the gel beverage, an exosome derived from panax notoginseng callus cultured in a laboratory is used as a core active component, is modified through phosphatidylserine-aminated pectin-genipin and is embedded into a hydrogel matrix composed of carboxymethyl chitosan and sodium alginate, so that the exosome is protected from being degraded in the stomach, and the activity of the exosome in the stomach is improved. The exosome can be effectively released under the intestinal pH and flora environment, so that the targeted delivery of the intestinal tract is realized, and the preparation method is suitable for improving the intestinal inflammation and maintaining the intestinal health. The invention can effectively solve the technical problems of uncontrollable raw material quality and safety, low oral delivery stability and active ingredient availability and poor medication compliance of the existing plant exosome.

The invention belongs to the technical field of water treatment materials, and particularly discloses chitosan-polyvinyl alcohol photo-thermal aerogel as well as a preparation method and application thereof. Chitosan, polyvinyl alcohol and genipin are cross-linked to prepare the chitosan-polyvinyl alcohol photo-thermal aerogel, and the chitosan-polyvinyl alcohol photo-thermal aerogel has the advantages of being simple in preparation method, low in cost, low in energy consumption, high in light absorption rate, high in evaporation rate, good in salt resistance and stability, capable of self-floating and the like; meanwhile, the hydrophilic advantages of the chitosan and the polyvinyl alcohol are combined, the hydrophilic performance is remarkably enhanced, the efficient evaporation performance is shown, the purpose of efficient evaporation can be achieved, and the chitosan / polyvinyl alcohol composite material has huge potential application prospects in the fields of seawater desalination, sewage treatment and the like.

A natural aldehyde-functionalized all-biomass aerogel and a preparation method thereof, the method comprises: (1) dispersing chitosan in a starch-like fiber solution and stirring to obtain a uniform mixed solution; (2) adding genipin as a crosslinking agent to the mixed solution obtained in step (1), heating and stirring for a period of time to obtain an aerogel precursor solution, and allowing the same to stand to undergo crosslinking to obtain a hydrogel; (3) freezing the hydrogel obtained in step (2), and then freeze-drying to obtain an aerogel; (4) soaking the aerogel obtained in step (3) in a natural aldehyde solution for graft modification, then removing and rinsing, and subsequently drying to obtain the aldehyde-functionalized aerogel.

The invention relates to a preparation method of an insect-proof lyocell fiber, and belongs to a functional fiber preparation method in the chemical field. The invention provides a bio-based microcell barrier packaging solution aiming at three major defects of easy breakage, non-environmental response release and toxicity of a chemical cross-linking agent in the existing microcapsule coating. The pH response type microcapsule is constructed through double-layer alternate self-assembly of chitosan and phytic acid, a compact network barrier is formed by electrostatic crosslinking of positive and negative charges, and the structural stability is enhanced by combining a natural cross-linking agent genipin; in the fiber loading stage, plasma pretreatment is adopted to increase the surface roughness, vacuum negative pressure drives microcapsule permeation, and steam setting promotes anchoring setting. Core innovations include an intelligent release mechanism, washability breakthrough, ecological safety and actually measured performance display. The method solves the problem that the lyocell fiber is difficult to decompose the permethrin in the NMMO solvent system, and has the advantages of efficient protection and environmental friendliness.

The invention discloses a biochar-reinforced hydrogel slow-release fertilizer and a preparation method thereof, and relates to the technical field of fertilizers. Comprising the following steps: S1, preparing sorghum straw biochar; s2, adding the sorghum straw biochar and a potassium nitrate and ammonium dihydrogen phosphate solution into a polymer monomer mixed solution to obtain a biochar gel mixed solution; s3, adding the genipin solution into the biochar gel mixed solution, stirring, performing ultrasonic treatment, freezing and unfreezing to obtain the biochar reinforced hydrogel slow-release fertilizer. Aiming at the technical defects of the hydrogel slow-release fertilizer, the performance of the hydrogel slow-release fertilizer is modified and enhanced by utilizing the biochar, and the biochar-enhanced hydrogel slow-release fertilizer is formed. The preparation method is simple in process and convenient to operate, the raw materials are cheap and easy to obtain, the cost is low, and the prepared biochar reinforced hydrogel slow-release fertilizer has the advantages of good slow-release performance, high water retention capacity and environmental stability, and is of great significance in popularization and application of the hydrogel slow-release fertilizer.

The invention provides a rutin-modified soybean protein isolate-pectin-genipin nano-particle carrier and a preparation method of the rutin-modified soybean protein isolate-pectin-genipin nano-particle carrier. The preparation method of the nanoparticle carrier comprises the following steps: preparing a soybean protein isolate solution, a soybean protein isolate solution after pH shift, an aqueous solution containing rutin-modified soybean protein isolate and an aqueous solution containing rutin-modified soybean protein isolate-pectin; the aqueous solution contains rutin-modified soy isolate protein-pectin-genipin, the concentration of the genipin is 0.05 mg / mL, and the rutin-modified soy isolate protein-pectin-genipin nano-particle carrier is prepared from the rutin-modified soy isolate protein-pectin-genipin nano-particle carrier. The invention further provides application of the rutin-modified soy isolate protein-pectin-genipin nanoparticle carrier. The rutin-modified soy isolate protein-pectin-genipin nanoparticle carrier is used for sustained release of gastric drugs and targeted release of drugs in small intestines. According to the preparation method disclosed by the invention, a rutin-modified soybean protein isolate-polysaccharide nanoparticle carrier with a shell-core structure can be formed, gastric acid erosion can be effectively resisted, and the rutin-modified soybean protein isolate-polysaccharide nanoparticle carrier is delivered to small intestines in a targeted manner.

The invention relates to a dressing for promoting healing of diabetic wounds. Chitosan is dissolved in a hydrochloric acid solution at room temperature to obtain a chitosan solution; the preparation method comprises the following steps: dissolving loxoprofen in ethanol activated by 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / N-hydroxysuccinimide, dropwise adding into a chitosan solution, adding ethanol while stirring at a high speed by using a magnetic rod to form a transparent solution, and stirring at a low speed in the dark; air-drying the solution in a drying oven to form a solid film, and thoroughly washing the solid film in ethanol to obtain a chitosan-loxoprofen conjugate; the preparation method comprises the following steps: adding chitosan-loxoprofen into a phosphate buffer solution to form a chitosan-loxoprofen solution; dissolving genipin in a phosphate buffer solution to obtain a genipin solution, stirring and mixing the chitosan-loxoprofen solution and the genipin solution at a high speed, cross-linking, and freezing in a refrigerator to obtain the chitosan-loxoprofen / genipin sponge bracket. The dressing disclosed by the invention can effectively relieve chronic inflammation, remarkably improve skin tissue regeneration and stimulate angiogenesis.

The invention discloses a microbial soil conditioner and a preparation method thereof, and relates to the technical field of soil improvement. The method comprises the following steps: culturing heavy metal-resistant chlorella and aspergillus niger to obtain a mixed bacterial suspension, combining the mixed bacterial suspension with a composite chelating modifier prepared by reacting chitosan quaternary ammonium salt, ethylenediamine tetraacetic acid and epichlorohydrin, carrying out crosslinking by using genipin to obtain a functional microbial agent, and carrying out pyrolysis and acid oxidation on corn straws as a raw material to obtain the heavy metal-resistant chlorella modified functional microbial agent. The preparation method comprises the following steps: preparing a nano zero-valent iron-biochar composite material, reducing and loading ferrous ions through sodium borohydride, preparing the nano zero-valent iron-biochar composite material, mixing the nano zero-valent iron-biochar composite material with zeolite, bentonite and a silane coupling agent, carrying out spray drying to prepare a porous carrier substance, and finally stirring and mixing an organic fertilizer complex microbial inoculant, the functional microbial inoculant and the carrier substance, and aging to prepare the soil conditioner. The prepared conditioner has a good remediation effect on soil heavy metal pollution.

The invention relates to the technical field of medicines, in particular to a stable drug-loaded microcapsule and a preparation method thereof. According to the method, A-type gelatin and succinic anhydride modified B-type gelatin are adopted to synergistically construct a layered composite shell layer, genipin is added step by step to realize progressive crosslinking, and the interface structure and the controlled release performance are optimized. The microcapsule prepared by the invention has high encapsulation efficiency, controllable release and excellent storage stability, adopts an innovative multi-molecular-weight gelatin layered design and a step-by-step cross-linking strategy, and takes into account the dual requirements of strong encapsulation and slow release and controlled release, so that the vitamin B6 is prevented from being influenced by environmental degradation, and the efficacy and compliance of a preparation are improved. The invention provides a new technical scheme for development of controlled release preparations of water-soluble vitamins and related drugs.

The invention belongs to the field of polymer chemistry and biological medicine materials, and relates to application of a polymer polysaccharide slow-release carrier in medicinal and edible components and a preparation method of the polymer polysaccharide slow-release carrier. The carrier is composed of phytic acid-genipin cross-linked modified chitosan, tannic acid, sodium lactate, glycerin, vitamin E acetate, sodium alginate and deionized water. The phytic acid-genipin cross-linked modified chitosan is prepared by reacting chitosan with phytic acid and genipin, and has reversible cross-linking and polydentate coordination properties; the tannic acid and the modified chitosan can form a multi-point hydrogen bond and esterification network. The carrier is prepared through sol-gel forming or spray drying, is stable in structure, good in dispersity, high in drug loading capacity, stable in an acid environment and controllable in release under a neutral condition, remarkably improves the slow release performance and bioavailability of medicinal and edible components, and is suitable for functional food and drug delivery systems.

The invention relates to composite aerogel as well as a preparation method and application thereof, and belongs to the technical field of bio-based materials, the composite aerogel is prepared from the following components in parts by mass: 2-10 parts of aldehyde modified cellulose nanocrystals, 3-10 parts of a silk fibroin solution, 5-15 parts of a genipin ethanol solution and 0.2-0.5 part of zinc chloride; the preparation method of the composite aerogel comprises the following steps: (1) uniformly mixing aldehyde modified cellulose nanocrystals, a silk fibroin solution, a genipin ethanol solution and zinc chloride, and reacting to form hydrogel; (2) adding into a mold, and freezing at constant temperature for 4-8 hours; (3) replacing water with tert-butyl alcohol; and (4) drying at normal pressure for 24-48 hours to obtain the composite aerogel. The aerogel prepared by the invention has a hierarchical pore structure and an adjustable function, has high mechanical properties, specific surface area, porosity and degradation rate, and is suitable for the fields of biomedicine, environmental protection and energy.

The invention discloses a composition for treating intractable skin infection, sores and ulcers and inflammation as well as a preparation method and application of the composition, and belongs to the technical field of functional compositions. The composition is prepared from the following components in parts by mass: 1 to 5 parts of baicalin, 0.5 to 3 parts of antibacterial alkaloid, 2 to 6 parts of asiaticoside, 3 to 8 parts of salvianolic acid B, 1 to 4 parts of gallic acid, 5 to 10 parts of rhizoma bletillae polysaccharide, 3 to 10 parts of konjac glucomannan, 3 to 5 parts of chitosan, 8 to 20 parts of glycerol, 0.5 to 2 parts of genipin, 1 to 3 parts of calcium chloride, 1 to 3 parts of laurocapram and 40 to 80 parts of water. The antibacterial alkaloid comprises berberine or phellodendrine. Based on deep understanding of an intractable skin pathological mechanism, the components are scientifically matched, and the composition shows a remarkable synergistic effect in in-vitro antibacterial, anti-biofilm and anti-inflammatory experiments. The preparation process is simple, low in cost and suitable for industrial production.

The invention discloses a Hedyotis diffusa extract, comprising a hedyotis diffusa glycoside content of 2500-4000 ppm, deacetylated hedyotis diffusa methyl ester, scutellariae glycoside methyl ester, and hedyotis diffusa glycoside content of 4500-6500 ppm, a total flavonoid content of less than 100 ppm, no characteristic color reaction for anthraquinone identification, hedyotis diffusa acid content of less than 100 ppm, deacetylated hedyotis diffusa acid content of less than 100 ppm, and geniposide acid content of less than 100 ppm, and a pH value of 6.0-7.0. The extract is obtained by vacuum ultrasound, centrifugation, and vacuum concentration, followed by acid adjustment to a pH of 2.5-3.0, followed by aging, membrane filtration, and purification by ion exchange column chromatography to obtain a permeate A and a Hedyotis diffusa alkaloid eluate J1. The permeate A is filtered through a membrane, separated by molecular imprinting polymerization adsorption, vacuum concentrated, and ultrafiltered. Finally, the pH is adjusted to 6-7 with J1, and the extract is sterilized by heat preservation.

The invention discloses an eucommia ulmoides wood controllable carbonization-gradient hooping phenol fragrance barrel for white spirit, and belongs to the technical field of wine brewing equipment. In order to solve the problems that a traditional oak barrel is high in cost, an eucommia wood barrel is incomplete in pretreatment, uneven in structural stress and poor in flavor controllability, eucommia wood with the tree age of 18-22 years is adopted as a base material, and pretreatment of segmented steaming, microwave degreasing and gradient drying is conducted; the barrel body is provided with a controllable carbonization modification layer, a 304 stainless steel gradient hoop enhancement layer, a triple-closing sealing layer and a flow guide groove functional layer, and a composite fragrant juice activation process is matched. The barrel can dissolve active ingredients of eucommia ulmoides such as geniposide and aucubin, the leakage rate is smaller than or equal to 0.05%, the content of guaiacol is increased by 42 times compared with a traditional pottery jar, the cost is reduced by 60% compared with an imported oak barrel, and the barrel is suitable for high-quality ageing of Chinese high-degree white spirit.

The present invention belongs to the technical field of home furnishings, and provides a material for preparing polymeric air fibers, and a preparation method therefor and the use thereof. The preparation method comprises: preparing a ceramic powder doped with antibacterial TiO2 / ZnO / ZrO2; depositing magnetic ferroferric oxide thereon; after the surface is modified by tannic acid, adding same to a water-soluble chitosan solution; immersing same in a TPEE air fiber membrane prepared by means of melt-blowing; uniformly adding a genipin solution dropwise; heating and reacting same; and taking out the membrane, washing and drying same to obtain a material for preparing polymeric air fibers. The TPEE air fiber membrane prepared in the present invention has good mechanical properties, and the modified ceramic powder is uniformly dispersed in the TPEE air fiber membrane, achieving good antibacterial, environmental protection, immunity regulation, magnetic therapy, far-infrared heating and other effects, such that the prepared material for preparing polymeric air fibers has better overall performance. Thus, the material is a good mattress support material, and has broad application prospects.

The invention belongs to the technical field of medical dressings, and provides a hydrocolloid acne patch and a preparation method thereof. According to the invention, beta-cyclodextrin functionalized gelatin and adamantane functionalized hyaluronic acid are subjected to inclusion interaction to form a reversible cross-linked network, and hydroxypropyl trimethyl ammonium chloride chitosan and sodium carboxymethyl cellulose are subjected to electrostatic interaction to form a polyelectrolyte cross-linked network; the genipin is combined with a primary amine group amido bond to form a triple cross-linked network structure design of a covalent cross-linked network, and antibacterial components such as a gamma-cyclodextrin-salicylic acid inclusion compound are loaded, so that the excellent properties that the self-healing recovery rate is 90-95%, the water vapor transmission rate is 500-900g. M <-2 >. 24h <-1 >, and the peel strength is greater than or equal to 1.0 N / 25mm are realized; the technical problem that an existing hydrocolloid acne patch is insufficient in antibacterial persistence and self-healing and repairing capacity is solved, and wide application value is achieved.

This invention relates to the field of down fabric technology, specifically to a mite-proof and antibacterial composite down and its preparation method. The mite-proof and antibacterial composite down includes two outer fabric layers, two inner down-proof fabric layers, two nanocellulose / chitosan composite layers, and down filling. The nanocellulose / chitosan composite layers are prepared from the following components: aqueous polyurethane emulsion, nanocellulose, chitosan, chitosan-modified wood vinegar powder, natural genipin, and a dispersant. Chitosan is added in the form of an acetate-sodium acetate buffer solution with a pH of 4.0–4.8. This invention, through the synergistic effect of chitosan-modified wood vinegar powder and nanocellulose, combined with an aqueous polyurethane matrix, can simultaneously achieve high repellency, high antibacterial rate, and excellent wash resistance. Furthermore, the nanocellulose enhances the interfacial bonding strength of the nanocellulose / chitosan composite layer, significantly improving interlayer adhesion strength and down-proof performance.

The invention discloses low-caffeine nerve stimulation tea wine and a preparation method thereof, the low-caffeine nerve stimulation tea wine is prepared by blending eucommia wood aged tea wine, cherry wood aged tea wine and cherry wood / Hainan dalbergia odorifera wood aged tea wine with different baking degrees, and the mass ratio of geniposidic acid to salidroside to formononetin in the wine body is (2-30): (1-15): 1. The mass ratio of the genkwanin to the alpinia japonica to the sesamol is (0.5-8): (0.15-6): 1, the mass ratio of the isoliquiritigenin to the vitexin to the syringaldehyde is 1: (0.15-5): (4-18), and the total content of the geniposidic acid, the salidroside, the formononetin, the genkwanin, the alpinia japonica, the sesamol, the isoliquiritigenin, the vitexin and the syringaldehyde in the wine is 40-250 mg / 100 mL. By combining and matching the functional components in the wood and the proportion of the functional components, the antagonistic effect on caffeine nerve stimulation in the tea wine is achieved.

The invention discloses a bio-based double-core high-elastic jean fabric, and particularly relates to the field of bio-based fiber materials. Weft yarns of the fabric adopt bio-based double-core elastic twisted yarns as core yarns and covering yarns wrapped by cotton fibers, and warp yarns are pure cotton yarns. The preparation method comprises the steps that chitosan and zinc lignosulfonate are blended, spun and crosslinked, and elastic fiber A is prepared to serve as first core yarn; blending silk fibroin with epoxidized natural rubber latex containing a vulcanizing agent, performing wet spinning, gelation and steam vulcanization, and performing genipin cross-linking to obtain an elastic fiber B as a second core yarn; the two kinds of core yarn are doubled and entangled through an air network to obtain double-core plied yarn; taking the yarn as core yarn, wrapping the yarn with cotton roving, and preparing core-spun weft yarn through a siro spinning process; and finally, weaving the fabric and pure cotton warp yarns into gray fabric, and performing desizing, dyeing, sizing and water washing treatment to obtain the final fabric. The fabric is excellent in elasticity, high in bio-based content, comfortable to wear and environmentally friendly.

The invention relates to and provides a fingerprint spectrum of musk-chuan NaoLiantong granules and a detection method for quantitative analysis of multiple components by single marker. The fingerprint spectrum detection method has the characteristics of simplicity and convenience in operation and good stability and reproducibility. 13 common peaks exist in an HPLC (High Performance Liquid Chromatography) fingerprint spectrum of 15 batches of musk-chuan naoeutong granules, and 7 components in the fingerprint spectrum, namely geniposidic acid, chlorogenic acid, cowherb seed flavonoid glycoside, ferulic acid, senkyunolide I, salvianolic acid B and tanshinone IIA, are identified. The similarity of the 15 batches of the musk and chuan naoliantong granules is 0.961-1. According to the fingerprint spectrum detection method, 13 representative common characteristic peaks are determined so as to comprehensively reflect the internal quality characteristics of the musk-chuan naoliantong preparation.

The invention belongs to the technical field of wound repair, and particularly relates to a PRF-based wound repair material and a preparation method thereof. The PRF-based wound repair material is prepared from the following raw materials in parts by weight: 80 to 100 parts of PRF gel, 50 to 150 parts of Mn-MBG / quercetin composite powder and 0.5 to 2 parts of genipin, the PRF gel is used as a bioactive carrier, a natural fiber protein network is provided for building a support for cell growth and active substance release, growth factors contained in the PRF gel interact with Mn-MBG / quercetin composite powder, stable loading and slow release of quercetin are achieved, and the regulation limitation of PRF single activity on complex wounds is made up; genipin intensifies the structural stability of the PRF fiber network in a targeted manner, endows the material with a physical support capability adapted to a wound repair period, and realizes synergistic improvement of biocompatibility, antibacterial effect, healing promotion capability and structural stability.

The invention discloses a hydrogel dressing with antibacterial property, antioxidant property and pH responsiveness as well as a preparation method and application of the hydrogel dressing, and belongs to the technical field of biomedical materials. An aldehyde group generated after ring opening of genipin as a chemical cross-linking agent and an amino group in a high-molecular polymer are subjected to a Schiff base reaction to realize chemical cross-linking, puerarin molecules are self-assembled through non-covalent bonds including hydrogen bonds and hydrophobic interaction, and a gel network is formed; and Ag-coated CR composite nanoparticles synthesized by a microalgae extract and silver nitrate are loaded. The multifunctional hydrogel material provided by the invention has antibacterial, antioxidant and pH-responsive properties, shows excellent antibacterial ability for common pathogenic bacteria such as escherichia coli, staphylococcus aureus and the like, and can effectively inhibit wound infection.

The invention discloses a gastric mucosa repairing composition based on cuttlebone and oxhide gelatin and a preparation method of the gastric mucosa repairing composition. The gastric mucosa repairing composition comprises cuttlebone active components, modified oxhide gelatin and probiotics, the cuttlebone active component comprises nano-scale particles; the modified oxhide gelatin is a porous scaffold material subjected to genipin crosslinking treatment; the probiotics comprise lactobacillus reuteri and bifidobacterium. According to the application, through the compounding of the nanocrystallized cuttlebone active component, the genipin cross-linked and modified porous oxhide gelatin scaffold, the specific probiotics and the licorice total flavonoids, a multi-dimensional synergistic repair system is adopted, nano-calcium can quickly neutralize gastric acid and locally stop bleeding, cuttlebone polysaccharide and active peptide can up-regulate expression of growth factors such as EGF and VEGF, and the effect of stopping bleeding is achieved. Proliferation and migration of epithelial cells and fibroblasts are directly driven; the modified oxhide gelatin forms a stable bionic adhesive protective film, and the stable bionic adhesive protective film is used as a three-dimensional scaffold to guide cells to crawl.

The invention discloses an antibacterial emulsion for skin and a preparation method thereof, and belongs to the technical field of emulsion medicines. The antibacterial emulsion is prepared from the following raw materials in parts by weight: 3 to 5 parts by weight of modified chitosan, 10 to 20 parts by weight of cross-linked oxidized cyclodextrin inclusion compound, 0.1 to 0.15 part by weight of genipin, 60 to 70 parts by weight of water phase matrix and 10 to 15 parts by weight of oil phase matrix. The antibacterial emulsion prepared by the preparation method disclosed by the invention has a good antibacterial effect and a transdermal effect.

This invention relates to the field of biological hemostatic materials technology, specifically a biological hemostatic dressing, its preparation method, and its application. The dressing consists of a core layer, an intermediate layer, and a surface layer, forming a gradient pore structure through electrospinning and achieving gradient stabilization through genipin cryo-crosslinking. The preparation process includes raw material pretreatment, layered spinning, cryo-crosslinking, and post-treatment. It can rapidly activate coagulation, provide long-lasting antibacterial effects, and promote tissue regeneration, making it suitable for scenarios such as wound hemostasis and wound repair. Through the three-layer gradient structure and the material's dynamic response, it achieves a temporal adaptation of rapid coagulation during the hemostatic phase, antibacterial and anti-inflammatory effects during the inflammatory phase, and tissue regeneration during the proliferative phase, overcoming the functional limitations of single materials.