204 results about "Intestinal inflammation" patented technology

The present invention provides a functional probiotic fermented fruit and vegetable powder preparation method, a functional probiotic fermented fruit and vegetable powder product is prepared by low temperature spray drying method, and the advantages are in that: (1) vitamin and dietary fiber and other nutritional components in raw fruits and vegetables can be effectively saved, after fermentation, free amino acid and organic acid contents are increased greatly, the product not only has good nutrition, color and flavor, and good water solubility, is free of any flavor and pigments, and belongs to pure natural green food; (2) the activity of probiotics in the product can be effectively saved (live bacteria number is 106cfu /g-1010cfu / g), a large number of active probiotics have the special beneficial functions of regulating the human body intestinal environment, preventing intestinal inflammation and cancer, improving constipation and other functions, and common fruit and vegetable powder does not have the special beneficial functions; (3) the preparation method has the advantages of low processing equipment investment, high efficiency and low energy consumption, the cost can be reduced by more than 80%, the production is easy to enlarge, and the preparation method is suitable for industrial continuous production, and can truly meet the needs of ordinary consumers.

The invention relates to lactobacillus plantarum ZS2058 and application thereof. The lactobacillus plantarum ZS2058 and the application have the advantages that colitis symptoms of diarrhea, stool occult blood, hematochezia and the like of mice can be effectively improved by the lactobacillus plantarum ZS2058, increase of disease activity indexes (DAI) can be suppressed, change of the lengths of colons of the mice can be improved, the activity of myeloperoxidase (MPO) can be obviously reduced, and the lactobacillus plantarum ZS2058 can be used for preparing medicine for preventing and treating intestinal inflammation or producing food beneficial to the intestinal health.

The invention discloses a bamboo powder feed and a method for feeding a rabbit, relates to development and application of bamboo in cultivation industry and also relates to a feed, in particular to a feed and the feeding method of the rabbit. The bamboo powder feed comprises bamboo poles and/or bamboo powder, wherein the bamboo powder is made by smashing and drying bamboo leaves and is used in a mixed way according to a proportion of 10-18 percent of the total quantity of the feed, namely, 25 percent of corn starch, 19.6 percent of wheat bran, 18.5 percent of bean pulp, 0.4 percent of silkworm chrysalis, 12 percent of alfalfa meal, 15 percent of bamboo powder and 9.5 percent of micro-element additive. The bamboo powder feed is suitable for growth demand of herbivore and can partially or completely substitute the traditional fiber raw material such as alfalfa and the like, on the basis of ensuring feed nutrients, herbage raw materials consumption is reduced, grazing and land resources are saved, common diseases such as respiratory tract, intestinal inflammation and the like of the rabbit can be effectively prevented, rabbit growth is facilitated, and growth rate of the rabbit can be accurately improved; and meanwhile, bamboo fiber is more resistant to digestion, so that the total consumption of the feed is relatively reduced, and cultivation cost is saved.

The invention discloses health-care medicinal liquor with the function of invigorating kidney and a preparation method thereof which belong to the technical field of traditional Chinese medicine. The health-care medicinal liquor is prepared from the following raw materials in weight portion: distilled spirit, and Chinese herbal medicines of aweto, ginseng, fructus schizandrae, medlar, actinolite, male silk moth, astragalus root, herba epimedii, herba cistanches, semen alli tuberosi, yam and tuckahoe. The total effective rate of the health-care medicinal liquor for renal deficiency, renal hypofunction patients, nephropathy, prostatitis, rheumatoid arthritis, cervical spondylopathy and lumbar intervertebral disc protrusion can reach over 90 percent. The health-care medicinal liquor also has auxiliary treatment and health-care function on gastritis, gastric cold, intestinal inflammation, irregular menses, adnexitis, hyperplasia of mammary glands, hypopiesis and arrhythmia. The health-care medicinal liquor has a simple concoction process, available material source, no risk in production, transportation and storage, and wide market prospect.

Disclosed herein are methods for treating an inflammatory condition in a patient comprising administering an agent that inhibits the signaling activity of MCH, thereby inhibiting the inflammatory response in the tissue, and in a mammal comprising administering to the mammal an effective amount of an agent that inhibits MCH activity, MCH binding to an MCH receptor or the signaling activity of an MCH receptor that mediates intestinal inflammation.

The present invention relates to one or more of the phytocannabinoids tetrahydrocannabivarin (THCV); cannabigerol (CBG); cannabichromene (CBC); and cannabidivarin (CBDV) for use in the treatment of intestinal inflammatory diseases. Preferably the intestinal inflammatory disease is either ulcerative colitis or Crohn's disease.

The present invention relates to methods of reducing the risk of occurrence of, and/or treating, necrotizing enterocolitis (“NEC”) or inflammatory bowel disease (“IBD”) comprising administering, to a subject in need of such treatment, an effective amount of a gap junction enhancing agent (“GJEA”), for example a peptide (“GJP”) or peptide analog (“GJPA”). It is based, at least in part, on the discovery that greater functionality of gap junctions between enterocytes increases their rate of migration and reduces the severity of intestinal inflammation.

The application relates to methods based on modulating mammalian intestinal microbiota and related probiotic and prebiotic compositions. Specifically, the application relates to the use of novel bacterial genera Ileibacterium and Dubosiella, including their species I. valens (I. valens) and Dubosiella newyorkensis (D. newy), respectively, and closely related OTUs within the family Erysipelotrichaceae that resemble either Ileibacterium spp. or Dubosiella spp. with 90% 16S rRNA sequence identity, for modulating weight and intestinal inflammation and immunity (including modulating intestinal immune gene expression such as, e.g., modulating expression of RORγT, IL-17A, IL-17F, RegIIIγ, Relmβ, and Defβ), as well as for treatment and diagnosis of (i) obesity and related conditions such as metabolic syndrome and diabetes mellitus; (ii) allergic and autoimmune diseases, and (iii) gastrointestinal disorders (such as, e.g., inflammatory bowel disease (IBD), ulcerative colitis, Crohn's disease, and celiac disease).

The present inventors discovered for the first time that intestinal inflammation could be efficiently suppressed by suppressing the production or accumulation of chondroitin sulfate proteoglycans. Specifically, inflammation in the large intestine can be suppressed by using siRNA to suppress the expression of versican, which is one of the chondroitin sulfate proteoglycans. Compounds used as siRNA, such as nucleic acids, can be used as effective agents for suppressing intestinal inflammation. Furthermore, the above finding also suggests that such intestinal inflammation-suppressing agents can be found by screening for compounds that suppress the production or accumulation of chondroitin sulfate proteoglycans.

The invention discloses a composition comprising at least one long chain polyunsaturated fatty acid, at least one probiotic and a mixture of oligosaccharides, said mixture containing at least one N-acetylated oligosaccharide, at least one sialylated oligosaccharide and at least one neutral oligosaccharide, for use in the promotion of intestinal angiogenesis and of nutrient absorption and of enteral feeding tolerance and/or in the prevention and/or treatment of intestinal inflammation, such as necrotizing enterocolis, and/or in the recovery after intestinal injury and/or surgery. This composition is particularly adapted for use in infants, notably preterm infants.

The invention relates to piglet creep feed capable of improvingthe intestinal health and a preparation method of the piglet creep feed. The piglet creep feed is prepared from the following components in parts by weight: first components comprising 7-13 parts of broken rice, 15-24 parts of corns, 7-13 parts of whey powder, 7-15 parts of extruded soybeans, 3-8 parts of whole milk powder and 2-5 parts of blood serum protein powder; second components comprising 0.1-0.5 part of taxus chinensis leaf powder and 0.2-1 part of redwood leaf powder; third components comprising 0.1-0.3 part of zinc oxide, 0.01-0.1 part of calcium propionate, 0.05-0.5 part of lysine, 0.05-0.3 part of threonine, 0.02-0.04 part of an antioxidant and 1-3 parts of piglet premix. In a preparation process, the first components which account for 50%-60% of the total weight are mixed with the third components and then the components are stirred to prepare a mixture A; the residual first components are mixed with the second components and then the components are stirred to prepare a mixture B; and the mixture A and the mixture B are uniformly mixed and stirred to prepare the piglet creep feed. Compared with the prior art, the piglet creep feed provided by the invention has the effect of remarkably improving the intestinal functions of piglets, reducing the intestinal inflammation response and the diarrhea rate of weaned piglets, and improving the growth performance of the weaned piglets.

The invention relates to a glucan polymer, a polymer micelle and a medicine carrier system. The glucan polymer is prepared from glucan, 4-(hydroxymethyl)benzeneboronic acid pinacol ester and polyol fatty acid through reaction, wherein the glucan and the polyol fatty acid provide hydrophilic and hydrophobic units, so that the polymer can automatically form the micelle; the polymer formed by the glucan, the 4-(hydroxymethyl)benzeneboronic acid pinacol ester and the polyol fatty acid through chemical reaction is sensitive to hydrogen peroxide; the response can be fast generated on hydrogen peroxide in an environment of ROS high expression diseases (such as myocardial ischemial injury, atherosclerosis, intestinal inflammation and tumor); the micelle disassembly is caused, so that the medicinemolecules are fast released.

The present invention relates to a kind of composition containing plant lactobacillus LP-Onlly strain and its application in strengthening intestinal immunobarrier. The composition of the present invention can intervene the homing of intestinal lymphocyte, control the number of intestinal tract secretive IgA and intestinal lymphocyte, lower the endotoxin level, improve intestinal tract immunobarrier and prevent damage of intestinal tract immunobarrier caused by hunger, malnutrition, infection, etc, and prevent and treat intestinal inflammation, infectious diseases and immune disorder diseases.

Described herein are screening methods to identify therapeutic compositions for the treatment of an intestinal inflammation, inflammatory bowel disease or pathogen infection, as well as therapeutic methods and compositions useful for ameliorating an intestinal inflammation, inflammatory bowel disease or pathogen infection.

The invention discloses an application of an antibacterial peptide C-BF in preparation of medicines for preventing and treating weanling stress of piglets. The intestinal morphology can be improved by the antibacterial peptide C-BF; the villus height can be increased; the intestinal inflammation is relieved; the growth performance of weaned pigs is improved; the diarrhea rate is lowered; and the antibacterial peptide C-BF is dosed through intraperitoneal injection.

Described herein are methods and compositions related to Inflammatory Bowel Disease. Specifically TL1A drives regional intestinal inflammation and fibrosis and is differentially modulated by IFN gamma and IL-17a. In one embodiment, the present invention is a method of diagnosing a condition in a subject by determining the presence or absence of IFN gamma and/or IL-17 and diagnosing the subject.

The invention belongs to the technical field of medicine, and relates to application of indolepopionic acid to preparation of drugs for preventing and/or treating tumor radiotherapy side effect. Through research, the fact that indolepopionic acid can obviously improve intestinal injury of mice, caused by gama ray irradiation, is found, the improvement shows that the survival rate of laboratory mice is obviously improved, the weight is risen again, the intestinal inflammation level is obviously reduced, and paradoxical reaction of the laboratory mice does not occur, the fact that indolepopionicacid can be effectively applied to the prevention and/or treatment of tumor radiotherapy side effect is shown, and the indolepopionic acid is low in toxic and side effect, and effective before and after being taken, and has a wide application potential.

The invention discloses application of a Tibet saussurea laniceps extract to relieving fruit fly intestinal inflammation. The Tibet saussurea laniceps extract is obtained by using a water extraction method; a fruit fly intestinal immunologic function damage model repair test is performed on the Tibet saussurea laniceps extract to discover that the Tibet saussurea laniceps extract has good anti-inflammation activity and antioxidant activity and can be used for preparing anti-inflammation medicaments, particularly anti-intestinal inflammation medicaments.

The invention discloses an anti-stress preparation for pigs and a preparation method thereof. The anti-stress preparation comprises, by weight parts, 6-8 parts of costusroot, 6-8 parts of fructus aurantii immaturus, 3-4 parts of curcuma aerugionosa, 6-8 parts of tangerine peel, 4-7 parts of rhubarb, 3-6 parts of astragalus, 1-3 parts of scutellaria baicalensis, 6-10 parts of honeysuckle, 7-12 parts of hawthorn, 10-14 parts of raw malt, 3-6 parts of codonopsis pilosula, 1-5 parts of glucose oxidase, 5-7 parts of mannase, 0.8-1.0 part of 5-amino-levulinic acid and 3-4 parts of taurine. According to the anti-stress preparation for pigs and the preparation method thereof, the formula is comprehensively considered from aspects such as immunity boost, anti-stress, qi circulation and spleen strengthening, digestion promotion, stomach invigorating, reduction of intestinal inflammation reaction and oxidative stress, shortcoming in conventional technologies are overcome, anti-stress action is strengthened while growth is promoted, health conditions of pigs are enhanced obviously, and the death rate is greatly reduced.

A method for the differentiation of inflammatory bowel disease (IBD) from irritable bowel disease (IBS) followed by distinguishing ulcerative colitis and Crohn's disease from other gastrointestinal illnesses. This highly differential method first uses the presence of elevated lactoferrin as a marker of intestinal inflammation to differentiate IBD from IBS. Patients suspected of IBD are then analyzed for fecal anti-Saccharomyces cerevisiae antibodies (ASCA) as an indicator of Crohn's disease and fecal anti-neutrophil cytoplasmic antibodies (ANCA) as an indicator of ulcerative colitis. IBD patients are further monitored for intestinal inflammation using fecal lactoferrin to evaluate the effectiveness of medical therapy and to predict relapse. The apparatus comprises either a qualitative enzyme-linked immunoassay or other immunoassay that utilizes antibodies specific to human immunoglobins for the measurement of total endogenous lactoferrin, ASCA and ANCA in human feces. The method and apparatus can be used by healthcare providers to identify IBD and distinguish ulcerative colitis from Crohn's disease.

The invention discloses application of galanthamine in prevention and treatment for soybean meal-induced enteritis of fishes. According to a neuroregulation theory of intestinal mucosal immunity, in combination with two methods of disease modeling and biological information analysis, it is inferred that the galanthamine is a potential medicine for preventing and treating the soybean meal-induced enteritis; it is proved by an experiment that the galanthamine can activate expression of anti-inflammatory cytokines in intestinal tracts of bred fishes through addition into feed or intramuscular injection in backs, inhibit intestinal inflammations, maintain tight junctions of intestinal epithelium barriers, and inhibit intestinal epithelium apoptosis, therefore the enteritis caused by a soybeanmeal feed is relieved, recovery of growth of the fishes can be achieved, and therefore the galanthamine can be taken as a novel feed additive with an anti-inflammatory effect or an injection with an anti-inflammatory effect for injection operation.

The invention relates to a preparation method of polyphenol-amyloid fiber hydrogel for relieving acute intestinal inflammation of mice. Egg white lysozyme amyloid fiber is prepared through heating under a high-temperature acidic condition, polyphenol is simply added into the amyloid fiber, and reversible hydrogel is formed through self-assembly. By constructing an IBD animal model, the hydrogel isused for gavage treatment of the mice, and the inventor finds that the hydrogel can significantly relieve DSS-induced acute colitis. All the materials used in the invention are food-grade and are safer than medicines for preventing or treating intestinal inflammation, and a new thought is provided for developing tea polyphenol products and medicines having anti-inflammatory activity and improvedbioavailability.

The present invention provides a compound poplar flower oral liquor. Each 100 ml solution contains medicinal ingredient as follows: ofloxacin 4.0-7.0 g, atropine sulfate 0.03-0.05 g, poplar flower extract liquid 93-96 ml, each 1 ml poplar flowers extract liquid equals to 1.10-1.15 g of poplar flowers raw ingredient. The compound poplar flower oral liquid can prevent and treat diarrhea or intestinal inflammation of the animal efficiently, optimize treating effect. The compound poplar flower oral liquid is added into drinking water for animal in general, each 100 oral liquid is added with 200 jin water, and the patient animal can be cured after taking the oral liquid 2-3 days. The compound poplar flower oral liquid has obvious treating effect and does not relapse after taking.