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400 results about "Thrombolysis" patented technology
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Thrombolysis, also called fibrinolytic therapy, is the breakdown (lysis) of blood clots formed in blood vessels, using medication. It is used in ST elevation myocardial infarction, stroke, and very large pulmonary embolisms.
Method and apparatus for location and temperature specific drug action such as thrombolysis
A method is provided of localizing a drug action where the drug is present throughout a vascular system. The localization occurs to within a volume of blood in a blood vessel, the vascular system having an initial temperature substantially within a first temperature range. A temperature-specific enzyme is delivered throughout a vascular system including a volume of blood in a blood vessel, the temperature-specific enzyme having a working temperature within a prespecified temperature range that does not substantially overlap the first temperature range. A heat transfer element is delivered to a blood vessel in fluid communication with the volume of blood. The temperature of the heat transfer element is adjusted such that the volume of blood in the blood vessel is heated or cooled to the prespecified temperature range. In this way, the action of the temperature-specific enzyme is substantially limited to the volume of blood heated or cooled. In an alternative embodiment, the temperature-specific enzyme is localized to the volume of blood in the blood vessel, and the heat transfer element is disposed in fluid communication with the volume of blood in the blood vessel. The enzyme localization may occur by way of direct injection or by way of injection through a lumen of a catheter. The injection lumen of the catheter may be disposed at least partially adjacent or in combination with the heat transfer element and its associated inlet and outlet lumens.
Owner:ZOLL CIRCULATION
Compounds and methods for delivery of prostacyclin analogs
Owner:UNITED THERAPEUTICS CORP
Vascular filter system
A removable vascular filter system for capture and retrieval of emboli while allowing continuous perfusion of blood, comprising a porous filter membrane and a filter membrane support structure. This system is useful for any percutaneous angioplasty, stenting, thrombolysis or tissue ablation procedure. The system may minimize the incidence of stroke, myocardial infarction or other clinical complications that may be associated with these procedures.
Owner:CARDINAL HEALTH SWITZERLAND 515 GMBH
Compounds and methods for delivery of prostacyclin analogs
ActiveUS20050085540A1Improve oral bioavailabilityBiocideSenses disorderThrombusArterial Vasodilation
This invention pertains generally to prostacyclin analogs and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing cytoprotection, preventing atherogenesis and inducing angiogenesis. Generally, the compounds and methods of the present invention increase the oral bioavailability and circulating concentrations of treprostinil when administered orally. Compounds of the present invention have the following formula:
Owner:UNITED THERAPEUTICS CORP
Method and apparatus for location and temperature specific drug action such as thrombolysis
Owner:INNERCOOL THERAPIES INC
Thrombolysis and chronic anticoagulation therapy
InactiveUS7308303B2Sufficient amountAvoid the needElectrocardiographyMedical devicesDiseaseLife quality
Thrombolytic and / or anticoagulation therapy of the present invention includes implantation of the discharge portion(s) of a catheter and, optionally, one or more electrodes on a lead, adjacent tissue(s) to be stimulated. Stimulation pulses, i.e., drug infusion pulses and optional electrical pulses, are supplied by a stimulator implanted remotely, and through the catheter or lead, which is tunneled subcutaneously between the stimulator and stimulation site. Stimulation sites include the coronary arteries, coronary veins, cerebral arteries, other blood vessels, chambers of the heart, mesenteric vessels, deep vessels of the leg, and other locations. Disclosed treatments include drugs used for chronic treatment and / or prevention of thromboembolic disease, for acute treatment of thromboembolic disease, for acute treatment of thrombosis, and combinations of these. The invention reduces or eliminates the incidence of thromboembolic disease and related morbidities, improve symptoms resulting from thromboembolic disease, and improve patient quality of life.
Owner:BOSTON SCI NEUROMODULATION CORP
Shape memory thin film embolic protection device with frame
InactiveUS20060100659A1Reducing macroReducing micro-embolizationSurgeryDilatorsContinuous perfusionVascular filter
A removable vascular filter system for capture and retrieval of emboli while allowing continuous perfusion of blood. This system is useful for any percutaneous angioplasty, stenting, thrombolysis or tissue ablation procedure. The system may minimize the incidence of stroke, myocardial infarction or other clinical complications that may be associated with these procedures.
Owner:VACTRONIX SCI LLC +1
Histotripsy for thrombolysis
Methods for performing non-invasive thrombolysis with ultrasound using, in some embodiments, one or more ultrasound transducers to focus or place a high intensity ultrasound beam onto a blood clot (thrombus) or other vascular inclusion or occlusion (e.g., clot in the dialysis graft, deep vein thrombosis, superficial vein thrombosis, arterial embolus, bypass graft thrombosis or embolization, pulmonary embolus) which would be ablated (eroded, mechanically fractionated, liquefied, or dissolved) by ultrasound energy. The process can employ one or more mechanisms, such as of cavitational, sonochemical, mechanical fractionation, or thermal processes depending on the acoustic parameters selected. This general process, including the examples of application set forth herein, is henceforth referred to as “Thrombolysis.”
Owner:RGT UNIV OF MICHIGAN
Method and apparatus for creating penumbra and infarct images
InactiveUS20020161292A1Computerised tomographsDiagnostic recording/measuringRadiologyCerebral blood volume
A method and apparatus for evaluating acute stroke patients and for determining whether a stroke patient will benefit from the use of thrombolysis therapy includes obtaining measurements of the cerebral blood flow and cerebral blood volume of the brain of a stroke patient, determining ischemic areas of the brain where the ischemic areas comprise the measurements of cerebral blood flow which are less than a first value and creating a penumbra-infarct map of the ischemic areas of the brain using the measurements. The infarct area corresponds to the area of the brain where cerebral blood volume is less than a second value. The penumbra area corresponds to the area of the brain where cerebral blood volume is greater than this second value. The method also includes determining a ratio of penumbra size to the total of penumbra size and infarct size. When the ratio is greater than a predetermined value, the stroke patient is a candidate for thrombolysis therapy.
Owner:UNIVERSITY OF LAUSANNE
Double-sacculus conduit for thrombolysis
ActiveCN102698354AImprove complianceImprove drug delivery efficiencyStentsBalloon catheterEngineeringBalloon catheter
The invention provides a double-sacculus conduit for thrombolysis, comprising a connecting device, a stress diffusion tube, a pushing rod, sacculuses, a conduit top section, an inner tube and a guide wire. The pushing rod is of a hollow structure; the inner tube passes through an inner cavity of the pushing rod and inner cavities of the sacculuses; a far end of the inner tube is fixed with the conduit top section; and the connecting device is provided with a first connector and a second connector. The sacculuses are of a double-sacculus structure and comprise a first sacculus, a second sacculus, a connection conduit tube section which is used for communicating the first sacculus with the second sacculus; the sacculuses are provided with micro-pores so that the first sacculus and the second sacculus can be expanded to form a sealed treating space between the first sacculus and the second sacculus when liquid medicine is introduced into the second connector; and the liquid medicine can enter the sealed treating space through the micro-pores. According to the double-sacculus conduit for the thrombolysis, the medicine feeding efficiency of medicaments can be improved.
Owner:MICROPORT NEUROTECH SHANGHAI
Thrombolysis In Retinal Vessels With Ultrasound
InactiveUS20080262512A1Reduce riskHigh resolutionImage enhancementLaser surgeryVenous occlusionBlood vessel
Systems and methods are described providing for the use of ultrasound energy to effect the dislodging of one or more blood clots inside blood vessels. Such clots can include those inside retinal vessels, especially in patients with central retinal vein occlusion. Embodiments of the present disclosure may be used for any retinal arterial or venous occlusion. In exemplary embodiments, a small probe can be inserted into the eye of a patient and placed over the retinal vessels. Acoustic streaming created by the probe can be directed to an area or region including targeted blood vessels, resulting in increased flow in one or more retinal veins and facilitating or effecting mechanical dislodging of one or more blood clots in the targets blood vessels. Exemplary embodiments can utilize ultrasonic energy produced at a frequency of approximately 44 MHz to 46 MHz with pulse repetition frequencies of approximately 100 Hz to 100 kHz.
Owner:DOHENY EYE INST
Hand-held imaging probe for treatment of states of low blood perfusion
InactiveUS20060025683A1Efficient seatingIncrease sound energyUltrasound therapyOrgan movement/changes detectionVascular obstructionBlood flow
A non-invasive hand-held treatment imaging probe for treatment of acute blood flow disturbances and states of low blood perfusion. The treatment imaging probe is operable to emit high intensity therapeutic mechanical acoustic waves while under ultrasonic imaging guidance. The probe has a substantially rigid application surface, sized to enable seating within a rib space of a patient (i.e. for cardiac applications), comprising the combination of an engagement face of an ultrasonic imaging transducer and an application end of a high powered therapeutic actuator operable in about the 1-500 kHz (and preferably 1-150 kHz) range. Treatment imaging probe can be used as an adjunct to thrombolytic therapy in the treatment of acute thrombotic vascular obstructions, such as in acute myocardial infarction, or alternatively to enhance localized delivery of angiogenic agents or other useful medications to targeted vascular regions.
Owner:AHOF BIOPHYSICAL SYST
Thrombolysis in retinal vessels with ultrasound
InactiveUS20140243712A1Reduce riskHigh resolutionUltrasound therapyEye surgeryVenous occlusionBlood vessel
Systems and methods are described providing for the use of ultrasound energy to effect the dislodging of one or more blood clots inside blood vessels. Such clots can include those inside retinal vessels, especially in patients with central retinal vein occlusion. Embodiments of the present disclosure may be used for any retinal arterial or venous occlusion. In exemplary embodiments, a small probe can be inserted into the eye of a patient and placed over the retinal vessels. Acoustic streaming created by the probe can be directed to an area or region including targeted blood vessels, resulting in increased flow in one or more retinal veins and facilitating or effecting mechanical dislodging of one or more blood clots in the targets blood vessels. Exemplary embodiments can utilize ultrasonic energy produced at a frequency of approximately 44 MHz to 46 MHz with pulse repetition frequencies of approximately 100 Hz to 100 kHz.
Owner:DOHENY EYE INST
Liquid-lowering health cookie and making method thereof
InactiveCN103583653ARich in proteinThrombolyticDough treatmentBakery productsTherapeutic effectLipid lowering
The invention discloses liquid-lowering health cookie. The liquid-lowering health cookie is made with, by weigh, 100-110 parts of flour, 40-50 parts of natto, 20-30 parts of mung bean powder, 1-2 parts of lotus leaf, 1-3 parts of Kuding, 2-3 parts of pubescent holly root, 1-2 parts of suberect spatholobus stem, 15-20 parts of broccoli, 10-14 parts of bamboo shoot, 8-12 parts of Chinese Mesona herb, 12-15 parts of wax apple, 20-30 parts of codfish, 5-8 parts of salt, 1-2 parts of cookie additive, and the proper amount of water. The natto added to the liquid-lowering health cookie is rich in protein, cellulose, calcium, iron and the like, and has the effects of thrombolysis, tumor suppression, blood pressure lowering, blood lipid lowering, oxidation resistance, osteoporosis prevention, blood clotting promotion and the like. The wax apple is a fine fruit for treating various diseases, has sweet taste and neutral nature, and has the effects of moistening lung, suppressing cough, eliminating phlegm, cooling blood, and astringing. The Chinese Mesona herb has the effects of clearing summer heat and cooling to excrete water, and has good therapeutic effect on hypertension, kidney diseases, diabetes, joint muscular pain and the like. The Kuding has the effects of clearing summer heat, improving eyesight and promoting intelligence, helping produce saliva and slake thirst, lowering blood lipid, preventing cancer and senescence, invigorating blood vessels and the like.
Owner:ANHUI JINHE GRAIN OIL GROUP
Basket for a catheter device
The present disclosure relates to a basket for a catheter designed to be deployed in complex vasculature to optimally treat vascular and arterial disease conditions such as blood clots, blood emboli, and deep vein thrombosis. The basket may comprise a shaft with a plurality of cuts along a portion of its length to form a plurality of tines that provide support for a plurality of porous tubes to form the limbs of the basket. The limbs of the basket expand radially away from the longitudinal axis of the basket when the longitudinal length of the basket is reduced. The limbs may also be connected to a drug delivery system, and in this manner, baskets of the present disclosure allow for the use of both mechanical and pharmaceutical means of thrombolysis.
Owner:THROMBOLEX INC
Bacillus adhaerens and its use in preparing health food having thrombolysis property
InactiveCN1464046AHigh activityStrong thrombolytic effectBacteriaBacteria material medical ingredientsAcid-fastSolubility
Bacilliis natto NLSSc with the preservation number CGMCC No. 0724 is Gram staining positive, non-acid fast, straight or near straight, (0.6-0.8)x(1.5-2.0) micron sized and aerobic; has mesial and un-swelled spore with the spore number inside one sporange cell not more than one, meso diamino heptane diacid and glycin contained in the cell wall, no characteristic saccharum and peripheral flagellum; and can be grown well in five kinds of natural organic culture medium and can form relatively thick mycoderm and butter fat colored colony with smooth edge in soybean cake powder culture medium. Bacilliis natto can be cultured in culture medium with nitrogen source to obtain thrombus dissolving matter natto kinase and the cultured matter may be extracted to obtain powdered matter as the additive for thrombolytic health food.
Owner:INST OF PROCESS ENG CHINESE ACAD OF SCI
Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin
InactiveUS6964764B2Formula stableReduce capacityPeptide/protein ingredientsInorganic non-active ingredientsWhole bodyThrombus
Methods of thrombolysis that allow the use of a fibrinolytic composition comprising reversibly inactivated acidified plasmin and the localized delivery of the plasmin to a vascular thrombotic occlusion are disclosed. Further disclosed is a method for administering a therapeutic dose of a fibrinolytic composition substantially free of plasminogen activator to a human or animal having a vascular thrombotic occlusion. The fibrinolytic composition includes a reversibly inactivated acidified plasmin substantially free of plasminogen activator. Intravascular catheter delivery of the fibrinolytic composition directly into or in the immediate vicinity of the thrombus is disclosed to minimize the systemic degradation of fibrin while retaining the maximum plasmin activity against the thrombus.
Owner:GRIFOLS THERAPEUTICS LLC
Thrombolysis lipid-lowering pellet for curing cardio-cerebrovascular disease
InactiveCN101284105AGood curative effectQuick resultsNervous disorderHydroxy compound active ingredientsDiseaseCentipede
The invention provides a Chinese traditional medicinal preparation for treating cardiovascular and cerebrovascular diseases, coronary heart disease, headache due to hypertension, tinnitus, deafness, extremity numbness, paralysis, dim sight, palpitation, oppressed feeling in chest, insomnia, etc., particularly a Rongshuangjiangzhi Pill for treating cardiovascular and cerebrovascular diseases. The preparation is prepared from scorpion, centipede, bloodsucker, notoginseng, angelica, ginseng, earthworm, white-stiff silkworm, tall gastrodia tuber, amomun fruit, cinnamon, ground beetle, Chinese wild ginger, borneol, tuber fleeceflower, oriental waterplantain tuber, rhubarb, milk vetch, root of red rooted salvia, chuanxiong rhizome, hawthorn, cyathula root, safflower, cassia seed, burreed tuber, zedoary root and licorice by mixing coarse powder and concentrate extracts proportionally; stirring; drying; pulverizing; sieving; and obtaining capsules. Based on the Chinese traditional medicinal theory for reinforcing body resistance and eliminating pathogenic factors and smoothing blood vessel, the preparation is effective in calming the liver to stop the wind, promoting blood circulation and smoothing collaterals and nourishing yin and tonifying the kidney, and has the advantages of good therapeutic effect, quick effect, safety and no toxicity, and simple formulation and preparation process.
Owner:连德峰
Serum marker capable of evaluating cerebral hemorrhage risk before thrombolysis and application thereof
InactiveCN105203749AAccurate Risk PredictionAccurately draw risk predictionsMaterial analysisPathologyHuman body
The invention relates to a serum marker capable of evaluating a cerebral hemorrhage risk before thrombolysis and application thereof and provides a kit used for detecting Occludin protein in the serum in the human body. When the kit comprising test strips is adopted, the kit has the advantages of being rapid, easy and convenient to use, accurate, low in cost, good in specificity and high in sensitivity, and the Occludin protein level result in peripheral blood before thrombolysis can be read within 5-15 min; when the kit comprising a 96-hole filter plate is adopted, the kit also has the advantage of being capable of rapidly testing the Occludin protein level in peripheral blood before thrombolysis. By adopting the kit for detecting the Occludin protein level in peripheral blood before thrombolysis (dosing), the risk that cerebral hemorrhage possibly occurs after thrombolysis can be effectively judged, a doctor is guided for medicine usage, and the great clinical significance is achieved.
Owner:THE SECOND PEOPLES HOSPITAL OF SHENZHEN
Suction catheter for thrombolysis and suction of thrombotic substance
InactiveCN105920720AEasy to handleAvoid the disadvantages of insufficient concentrationCatheterIntravenous devicesAspiration catheterThrombolysis
The invention relates to a suction catheter for thrombolysis and suction of thrombotic substance. The suction catheter comprises a central catheter, one end of the central catheter is connected with a suction connecting tube and an administration tube respectively, a liquid outlet of the suction connecting tube is connected with a middle tube, a liquid suction connecting head is arranged at each of two ends of the middle tube, the other end of the suction connecting tube is connected with a two-way valve, a liquid outgoing port end of the two-way valve is connected with a catheter joint, the other end of the catheter joint is connected with a rear-end suction catheter which is connected with a suction pump, a liquid incoming port end of the administration tube is connected with an administration one-way valve, and the other end of the administration one-way valve is connected with an administration injector. The suction catheter has the advantages of simple structure, convenience in operation, low manufacturing cost and convenience in clinical use.
Owner:HENAN YADU IND
Mechanical thrombus remover
A mechanical thrombus remover is provided. A thrombus suction system in the mechanical thrombus remover includes a suction device and a thrombus suction tube, wherein the suction system based on the structure provides the negative pressure in a manner different from the existing high-speed rotational siphon-forming manner based on the helical structure in that the negative pressure is provided ina manner different from the conventional suction system, negative pressure required by thrombus suction can be formed without high-speed rotation , thus effectively reducing the existing helical structure to form negative pressure process rotational speed is too fast to cause the temperature is too high and lead to the problem of guide wire fracture. In addition, the thrombus suction system and the thrombus crushing system of the invention are two mutually independent systems, and the mutual influence of the thrombus suction and the thrombus crushing process is effectively avoided.The procedure of thrombolysis is carried out in the thrombectomy head, which effectively reduced the probability of complications of hematuria and renal failure and the incidence of vascular perforation.
Owner:SHANGHAI BLUEVASCULAR MEDTECH CO LTD
Oligopeptide with thrombolysis activity, preparation method and application thereof
The invention discloses an oligopeptide modified by 4, 4, 5, 5-tetramethyl-1, 3-dioxy imidazoline-2-benzene-4'-oxygen acetyl and a preparation method thereof and also discloses the application thereof in treating cerebral thrombosis. The preparation method comprises the following step: respectively coupling Ala-Arg-Pro-Ala-Lys, Pro-Ala-Lys, Arg-Pro-Ala-Lys, Gly-Arg-Pro-Ala-Lys or Gln-Arg-Pro-Ala-Lys with the 4, 4, 5, 5-tetramethyl-1, 3-dioxy imidazoline-2-benzene-4'-oxygen acetyl, thus obtaining the compound of the invention. On a rat carotid and jugular bypass cannula thrombosis model, the compound of the invention shows excellent thrombolysis activity. On a rat cerebral thrombosis model, the compound of the invention shows excellent therapeutic effect on cerebral infarction.
Owner:CAPITAL UNIVERSITY OF MEDICAL SCIENCES
Seafood soup stock
ActiveCN102362679ANutritional balanceBeautiful and fragrantFood preparationPerilla oilTherapeutic effect
The invention discloses a seafood soup stock comprising materials of, by weight: 1 to 3 particles of peeled shrimps, 1 to 3g of carrot, 2 to 4g of onion, 2 to 4g of crab meat stick, 1 to 3g of squid, 1.5g of parsley, 1.1g of common salt, 0.2g of a shrimp flavoring, 0.5g of chicken essence, 4g of eggs, 0.05g of pepper, 0.7g of maize starch, 0.8g of a seafood extract, 0.2g of a dried scallop extract, 0.2g of ginger, 0.16g of hydrolyzed vegetable protein, 0.5g of glucose, 0.9g of maltodextrin, and 0.03g of perilla oil. The seafood soup stock provided by the invention is advantaged in balanced nutrition, good color, good flavor, good taste, and food mouthfeel. The soup stock contains various nutrients, and provides positive effects and auxiliary therapeutic effects for human healthy. The alpha-linolenic acid contained in the soup stock is an unsaturated fatty acid assists in reducing blood fat, reducing blood pressure anticoagulation / thrombolysis, improving cardiovascular and cerebrovascular performances, reducing total cholesterol concentration, preventing cardiovascular diseases, inhibiting myocardial infarction and cerebral infarction, and preventing and inhibiting the forming of tumors. The soup stock is rich in trace elements such as calcium, phosphorous, iron, and magnesium. Therefore, the soup provides good heart protecting, hypoglycemic and cancer preventing effects. Also, the soup stock is beneficial for the strength and the hematogenesis functions of skeletons.
Owner:JIANGSU NATURAL FOOD
A lower limb deep venous thrombosis thrombolysis curative effect prediction method and system based on machine learning
InactiveCN109598266AThrombolytic efficacy evaluation results are accurateImprove efficiencyMedical referencesRecognition of medical/anatomical patternsPredictive methodsThrombus
The invention discloses a lower limb deep venous thrombosis thrombolysis curative effect prediction method and system based on machine learning. The method comprises the steps: obtaining an area of interest of lower limb deep venous thrombosis from an MRI image; Performing image omics feature extraction on the region of interest of the lower limb deep venous thrombosis; And predicting the curative effect of lower limb deep venous thrombosis thrombolysis by adopting a machine learning method according to an image omics feature extraction result. The invention discloses a lower limb deep venousthrombosis thrombolysis curative effect prediction method and system based on machine learning. lower limb deep venous thrombolysis curative effect prediction is performed through image omics featureextraction and a machine learning method; The MRI imaging omics method and the machine learning technology are combined to predict the thrombolysis curative effect of the deep venous thrombosis of the lower limbs, the curative effect evaluation work can be completed through prediction before thrombolysis treatment, the method does not depend on experience of doctors any more, and the thrombolysiscurative effect prediction result is more accurate and higher in efficiency. The method can be widely applied to the field of medical image processing.
Owner:SHENZHEN UNIV +1
Lumbricus polypeptide having anticoagulant and thrombolytic effects, and enzymatic hydrolysis preparation method and application thereof
ActiveCN104004806AImprove bioavailabilityThe structure is simple and easy to understandPeptide preparation methodsFermentationHydrolysateHigh activity
The invention discloses a lumbricus polypeptide having anticoagulant and thrombolytic effects, and an enzymatic hydrolysis preparation method and an application thereof. The preparation method comprises the steps: cleaning and drying lumbricus dried bodies, and crushing into a powder; adding water, stirring, and centrifuging to obtain a protein precipitate; adding water to dissolve the protein, adding an alkaline protease with the ratio of the enzyme volume to the protein weight of 0.1-3 mL:100 g, and stirring; exterminating enzyme activity, adding trypsin with the ratio of the enzyme mass to the protein weight of 0.5-5 g:100 g, and stirring at the temperature of 25-60 DEG C; allowing the enzymatic hydrolysate to pass through an anion exchange column, collecting a part of eluate; and then passing through a macroporous adsorption resin, carrying out separation and purification, and collecting and drying to obtain a lumbricus anticoagulant peptide powder. A new source is added for high-activity anticoagulant active substances, the product activity is high, the preparation process is convenient and feasible, and the environment is protected; and the lumbricus polypeptide can be used as a raw material of foods for thrombosis prevention, thrombolysis and blood consistency reduction, is supplemented with lactose, mannitol and the like, and is made into a powder, a tablet, a capsule or an oral liquid.
Owner:广州速科食品有限公司
Methods and compositions for PDGF-C activation and inhibition
InactiveUS20060104978A1Inhibits downstream signallingPromote angiogenesisImmunoglobulins against growth factorsAntibody ingredientsTPA InhibitorsBiological activation
Methods for inhibiting angiogenesis comprising administering tissue-plasminogen activator (tPA) inhibitors, and pharmaceutical compositions suitable for the methods comprising the tPA inhibitors. Also provided are methods for stimulating angiogenesis comprising administering tPA to a patient in need thereof, and pharmaceutical compositions comprising an effective amount of tPA for the methods of stimulation. The present invention discloses that tPA is a specific PDGF-C activating protease, and that the CUB-domains in PDGF-CC directly interact with the protease, are required for efficient proteolysis, and released CUB-domains are tPA inhibitors. Preferably, the method and compositions of the present invention are used for simultaneously stimulating, or simultaneously inhibiting, thrombolysis and angiogenesis.
Owner:LUDWIG INST FOR CANCER RES
Pyrazine derivative and preparation method as well as application thereof to pharmacy
The invention relates to a pyrazine derivative which has a structure shown in a general formula I, and also discloses a synthesis method of the pyrazine derivative. The compound has an anti-oxidation effect and a thrombolysis effect, can be used for treating cerebral apoplexy caused by ischemia and can also be used for preparing medicaments for treating nerve system diseases, infectious diseases, metabolic system diseases, cardiac-cerebral vascular system diseases, degenerative aging diseases and the like caused by excess production of free radical and / or thrombosis.
Owner:JINAN UNIVERSITY
Medicine compound for curing rheumatism rheumatoid arthritis and preparation method thereof
The invention discloses a medicine compound for curing rheumatism rheumatoid arthritis and a preparation method thereof. The medicine compound contains more than 50 kinds of traditional Chinese medicine, such as radix angelicae tuhuo, ramulus mori, Gentiana macrophylla, asarum, Clematis chinensis, Caulis Trachelospermi, wild aconite root, radix aconiti lateralis preparata, earthworm, attacus altisima, scorpion, and the like. The medicine compound of the invention is mainly used for thrombolysis, depressurization, relieving rheumatic pains, nourishing vitality and relaxing vein, relaxing the muscles, stimulating the blood circulation, and adjusting the immunity of human body. The medicine compound has unique effect in curing anemofrigid-damp arthralgia, arthralgia and myalgia, deficiency of the kidney, female blood-insufficiency, hemiplegia, lumbar vertebra and cervical vertebra. Besides the medicine compound has the effect of recovering the nerve function which the other medicines cannot reach. The medicine compound of the invention has obvious effect on curing rheumatism rheumatoid arthritis and paralysis caused by rheumatism, is free from toxic side effect, takes effect quickly and is convenient to use without boiling.
Owner:胡国伟
Nattokinase composition capable of improving stability and oral curative effect and used for preventing thrombogenesis and thrombolysis
ActiveCN103948915APromote absorptionImprove stabilityPeptide/protein ingredientsPharmaceutical non-active ingredientsCurative effectThrombus
The invention provides a nattokinase composition capable of improving stability and oral curative effect and used for preventing thrombogenesis and thrombolysis. The nattokinase composition is characterized by comprising nattokinase and phosphatidylserine, wherein the weight ratio of the nattokinase to the phosphatidylserine is (100:1) to (100:1,000), preferably (100:1) to (100:100), and further preferably (100:3) to (100:30).
Owner:DELI WEI BEIJING BIOLOGICAL TECH
Dual-balloon thrombolysis catheter
The invention discloses a dual-balloon thrombolysis catheter. The dual-balloon thrombolysis catheter comprises a catheter body as well as a first balloon and a second balloon which are sequentially arranged on the outer circumference of the tip part of the catheter body along the axial direction of the catheter body, wherein the second balloon is closer to the tip of the catheter body than the first balloon; an inner cavity channel, a first catheter side cavity channel and a second catheter side cavity channel which are parallel to the axial direction of the catheter body are arranged in the catheter body; the first catheter side cavity channel is communicated with a medicine adding control valve; the second catheter side cavity channel is communicated with a pressure control valve, the first balloon and the second balloon; and the catheter body is provided with catheter side holes which are positioned between the tail end of the catheter body and the first balloon and are used for enabling the inner cavity channel to be communicated with the outside, and medicine adding micro-holes which are positioned between the first balloon and the second balloon and are used for enabling thefirst catheter side cavity channel to be communicated with the outside.
Owner:SHANGHAI KINDLY MEDICAL INSTR CO LTD
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