391 results about "Thrombolysis" patented technology

A method is provided of localizing a drug action where the drug is present throughout a vascular system. The localization occurs to within a volume of blood in a blood vessel, the vascular system having an initial temperature substantially within a first temperature range. A temperature-specific enzyme is delivered throughout a vascular system including a volume of blood in a blood vessel, the temperature-specific enzyme having a working temperature within a prespecified temperature range that does not substantially overlap the first temperature range. A heat transfer element is delivered to a blood vessel in fluid communication with the volume of blood. The temperature of the heat transfer element is adjusted such that the volume of blood in the blood vessel is heated or cooled to the prespecified temperature range. In this way, the action of the temperature-specific enzyme is substantially limited to the volume of blood heated or cooled. In an alternative embodiment, the temperature-specific enzyme is localized to the volume of blood in the blood vessel, and the heat transfer element is disposed in fluid communication with the volume of blood in the blood vessel. The enzyme localization may occur by way of direct injection or by way of injection through a lumen of a catheter. The injection lumen of the catheter may be disposed at least partially adjacent or in combination with the heat transfer element and its associated inlet and outlet lumens.

A removable vascular filter system for capture and retrieval of emboli while allowing continuous perfusion of blood, comprising a porous filter membrane and a filter membrane support structure. This system is useful for any percutaneous angioplasty, stenting, thrombolysis or tissue ablation procedure. The system may minimize the incidence of stroke, myocardial infarction or other clinical complications that may be associated with these procedures.

This invention pertains generally to prostacyclin analogs and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing cytoprotection, preventing atherogenesis and inducing angiogenesis. Generally, the compounds and methods of the present invention increase the oral bioavailability and circulating concentrations of treprostinil when administered orally. Compounds of the present invention have the following formula:

Thrombolytic and/or anticoagulation therapy of the present invention includes implantation of the discharge portion(s) of a catheter and, optionally, one or more electrodes on a lead, adjacent tissue(s) to be stimulated. Stimulation pulses, i.e., drug infusion pulses and optional electrical pulses, are supplied by a stimulator implanted remotely, and through the catheter or lead, which is tunneled subcutaneously between the stimulator and stimulation site. Stimulation sites include the coronary arteries, coronary veins, cerebral arteries, other blood vessels, chambers of the heart, mesenteric vessels, deep vessels of the leg, and other locations. Disclosed treatments include drugs used for chronic treatment and/or prevention of thromboembolic disease, for acute treatment of thromboembolic disease, for acute treatment of thrombosis, and combinations of these. The invention reduces or eliminates the incidence of thromboembolic disease and related morbidities, improve symptoms resulting from thromboembolic disease, and improve patient quality of life.

A removable vascular filter system for capture and retrieval of emboli while allowing continuous perfusion of blood. This system is useful for any percutaneous angioplasty, stenting, thrombolysis or tissue ablation procedure. The system may minimize the incidence of stroke, myocardial infarction or other clinical complications that may be associated with these procedures.

The invention provides a double-sacculus conduit for thrombolysis, comprising a connecting device, a stress diffusion tube, a pushing rod, sacculuses, a conduit top section, an inner tube and a guide wire. The pushing rod is of a hollow structure; the inner tube passes through an inner cavity of the pushing rod and inner cavities of the sacculuses; a far end of the inner tube is fixed with the conduit top section; and the connecting device is provided with a first connector and a second connector. The sacculuses are of a double-sacculus structure and comprise a first sacculus, a second sacculus, a connection conduit tube section which is used for communicating the first sacculus with the second sacculus; the sacculuses are provided with micro-pores so that the first sacculus and the second sacculus can be expanded to form a sealed treating space between the first sacculus and the second sacculus when liquid medicine is introduced into the second connector; and the liquid medicine can enter the sealed treating space through the micro-pores. According to the double-sacculus conduit for the thrombolysis, the medicine feeding efficiency of medicaments can be improved.

The invention discloses liquid-lowering health cookie. The liquid-lowering health cookie is made with, by weigh, 100-110 parts of flour, 40-50 parts of natto, 20-30 parts of mung bean powder, 1-2 parts of lotus leaf, 1-3 parts of Kuding, 2-3 parts of pubescent holly root, 1-2 parts of suberect spatholobus stem, 15-20 parts of broccoli, 10-14 parts of bamboo shoot, 8-12 parts of Chinese Mesona herb, 12-15 parts of wax apple, 20-30 parts of codfish, 5-8 parts of salt, 1-2 parts of cookie additive, and the proper amount of water. The natto added to the liquid-lowering health cookie is rich in protein, cellulose, calcium, iron and the like, and has the effects of thrombolysis, tumor suppression, blood pressure lowering, blood lipid lowering, oxidation resistance, osteoporosis prevention, blood clotting promotion and the like. The wax apple is a fine fruit for treating various diseases, has sweet taste and neutral nature, and has the effects of moistening lung, suppressing cough, eliminating phlegm, cooling blood, and astringing. The Chinese Mesona herb has the effects of clearing summer heat and cooling to excrete water, and has good therapeutic effect on hypertension, kidney diseases, diabetes, joint muscular pain and the like. The Kuding has the effects of clearing summer heat, improving eyesight and promoting intelligence, helping produce saliva and slake thirst, lowering blood lipid, preventing cancer and senescence, invigorating blood vessels and the like.

The present disclosure relates to a basket for a catheter designed to be deployed in complex vasculature to optimally treat vascular and arterial disease conditions such as blood clots, blood emboli, and deep vein thrombosis. The basket may comprise a shaft with a plurality of cuts along a portion of its length to form a plurality of tines that provide support for a plurality of porous tubes to form the limbs of the basket. The limbs of the basket expand radially away from the longitudinal axis of the basket when the longitudinal length of the basket is reduced. The limbs may also be connected to a drug delivery system, and in this manner, baskets of the present disclosure allow for the use of both mechanical and pharmaceutical means of thrombolysis.

Bacilliis natto NLSSc with the preservation number CGMCC No. 0724 is Gram staining positive, non-acid fast, straight or near straight, (0.6-0.8)x(1.5-2.0) micron sized and aerobic; has mesial and un-swelled spore with the spore number inside one sporange cell not more than one, meso diamino heptane diacid and glycin contained in the cell wall, no characteristic saccharum and peripheral flagellum; and can be grown well in five kinds of natural organic culture medium and can form relatively thick mycoderm and butter fat colored colony with smooth edge in soybean cake powder culture medium. Bacilliis natto can be cultured in culture medium with nitrogen source to obtain thrombus dissolving matter natto kinase and the cultured matter may be extracted to obtain powdered matter as the additive for thrombolytic health food.

A mechanical thrombus remover is provided. A thrombus suction system in the mechanical thrombus remover includes a suction device and a thrombus suction tube, wherein the suction system based on the structure provides the negative pressure in a manner different from the existing high-speed rotational siphon-forming manner based on the helical structure in that the negative pressure is provided ina manner different from the conventional suction system, negative pressure required by thrombus suction can be formed without high-speed rotation , thus effectively reducing the existing helical structure to form negative pressure process rotational speed is too fast to cause the temperature is too high and lead to the problem of guide wire fracture. In addition, the thrombus suction system and the thrombus crushing system of the invention are two mutually independent systems, and the mutual influence of the thrombus suction and the thrombus crushing process is effectively avoided.The procedure of thrombolysis is carried out in the thrombectomy head, which effectively reduced the probability of complications of hematuria and renal failure and the incidence of vascular perforation.

The invention discloses an oligopeptide modified by 4, 4, 5, 5-tetramethyl-1, 3-dioxy imidazoline-2-benzene-4'-oxygen acetyl and a preparation method thereof and also discloses the application thereof in treating cerebral thrombosis. The preparation method comprises the following step: respectively coupling Ala-Arg-Pro-Ala-Lys, Pro-Ala-Lys, Arg-Pro-Ala-Lys, Gly-Arg-Pro-Ala-Lys or Gln-Arg-Pro-Ala-Lys with the 4, 4, 5, 5-tetramethyl-1, 3-dioxy imidazoline-2-benzene-4'-oxygen acetyl, thus obtaining the compound of the invention. On a rat carotid and jugular bypass cannula thrombosis model, the compound of the invention shows excellent thrombolysis activity. On a rat cerebral thrombosis model, the compound of the invention shows excellent therapeutic effect on cerebral infarction.

The invention discloses a seafood soup stock comprising materials of, by weight: 1 to 3 particles of peeled shrimps, 1 to 3g of carrot, 2 to 4g of onion, 2 to 4g of crab meat stick, 1 to 3g of squid, 1.5g of parsley, 1.1g of common salt, 0.2g of a shrimp flavoring, 0.5g of chicken essence, 4g of eggs, 0.05g of pepper, 0.7g of maize starch, 0.8g of a seafood extract, 0.2g of a dried scallop extract, 0.2g of ginger, 0.16g of hydrolyzed vegetable protein, 0.5g of glucose, 0.9g of maltodextrin, and 0.03g of perilla oil. The seafood soup stock provided by the invention is advantaged in balanced nutrition, good color, good flavor, good taste, and food mouthfeel. The soup stock contains various nutrients, and provides positive effects and auxiliary therapeutic effects for human healthy. The alpha-linolenic acid contained in the soup stock is an unsaturated fatty acid assists in reducing blood fat, reducing blood pressure anticoagulation/thrombolysis, improving cardiovascular and cerebrovascular performances, reducing total cholesterol concentration, preventing cardiovascular diseases, inhibiting myocardial infarction and cerebral infarction, and preventing and inhibiting the forming of tumors. The soup stock is rich in trace elements such as calcium, phosphorous, iron, and magnesium. Therefore, the soup provides good heart protecting, hypoglycemic and cancer preventing effects. Also, the soup stock is beneficial for the strength and the hematogenesis functions of skeletons.

The invention discloses a lower limb deep venous thrombosis thrombolysis curative effect prediction method and system based on machine learning. The method comprises the steps: obtaining an area of interest of lower limb deep venous thrombosis from an MRI image; Performing image omics feature extraction on the region of interest of the lower limb deep venous thrombosis; And predicting the curative effect of lower limb deep venous thrombosis thrombolysis by adopting a machine learning method according to an image omics feature extraction result. The invention discloses a lower limb deep venousthrombosis thrombolysis curative effect prediction method and system based on machine learning. lower limb deep venous thrombolysis curative effect prediction is performed through image omics featureextraction and a machine learning method; The MRI imaging omics method and the machine learning technology are combined to predict the thrombolysis curative effect of the deep venous thrombosis of the lower limbs, the curative effect evaluation work can be completed through prediction before thrombolysis treatment, the method does not depend on experience of doctors any more, and the thrombolysiscurative effect prediction result is more accurate and higher in efficiency. The method can be widely applied to the field of medical image processing.

The invention discloses a lumbricus polypeptide having anticoagulant and thrombolytic effects, and an enzymatic hydrolysis preparation method and an application thereof. The preparation method comprises the steps: cleaning and drying lumbricus dried bodies, and crushing into a powder; adding water, stirring, and centrifuging to obtain a protein precipitate; adding water to dissolve the protein, adding an alkaline protease with the ratio of the enzyme volume to the protein weight of 0.1-3 mL:100 g, and stirring; exterminating enzyme activity, adding trypsin with the ratio of the enzyme mass to the protein weight of 0.5-5 g:100 g, and stirring at the temperature of 25-60 DEG C; allowing the enzymatic hydrolysate to pass through an anion exchange column, collecting a part of eluate; and then passing through a macroporous adsorption resin, carrying out separation and purification, and collecting and drying to obtain a lumbricus anticoagulant peptide powder. A new source is added for high-activity anticoagulant active substances, the product activity is high, the preparation process is convenient and feasible, and the environment is protected; and the lumbricus polypeptide can be used as a raw material of foods for thrombosis prevention, thrombolysis and blood consistency reduction, is supplemented with lactose, mannitol and the like, and is made into a powder, a tablet, a capsule or an oral liquid.

Methods for inhibiting angiogenesis comprising administering tissue-plasminogen activator (tPA) inhibitors, and pharmaceutical compositions suitable for the methods comprising the tPA inhibitors. Also provided are methods for stimulating angiogenesis comprising administering tPA to a patient in need thereof, and pharmaceutical compositions comprising an effective amount of tPA for the methods of stimulation. The present invention discloses that tPA is a specific PDGF-C activating protease, and that the CUB-domains in PDGF-CC directly interact with the protease, are required for efficient proteolysis, and released CUB-domains are tPA inhibitors. Preferably, the method and compositions of the present invention are used for simultaneously stimulating, or simultaneously inhibiting, thrombolysis and angiogenesis.

The invention discloses a medicine compound for curing rheumatism rheumatoid arthritis and a preparation method thereof. The medicine compound contains more than 50 kinds of traditional Chinese medicine, such as radix angelicae tuhuo, ramulus mori, Gentiana macrophylla, asarum, Clematis chinensis, Caulis Trachelospermi, wild aconite root, radix aconiti lateralis preparata, earthworm, attacus altisima, scorpion, and the like. The medicine compound of the invention is mainly used for thrombolysis, depressurization, relieving rheumatic pains, nourishing vitality and relaxing vein, relaxing the muscles, stimulating the blood circulation, and adjusting the immunity of human body. The medicine compound has unique effect in curing anemofrigid-damp arthralgia, arthralgia and myalgia, deficiency of the kidney, female blood-insufficiency, hemiplegia, lumbar vertebra and cervical vertebra. Besides the medicine compound has the effect of recovering the nerve function which the other medicines cannot reach. The medicine compound of the invention has obvious effect on curing rheumatism rheumatoid arthritis and paralysis caused by rheumatism, is free from toxic side effect, takes effect quickly and is convenient to use without boiling.

The invention provides a nattokinase composition capable of improving stability and oral curative effect and used for preventing thrombogenesis and thrombolysis. The nattokinase composition is characterized by comprising nattokinase and phosphatidylserine, wherein the weight ratio of the nattokinase to the phosphatidylserine is (100:1) to (100:1,000), preferably (100:1) to (100:100), and further preferably (100:3) to (100:30).

The invention discloses a dual-balloon thrombolysis catheter. The dual-balloon thrombolysis catheter comprises a catheter body as well as a first balloon and a second balloon which are sequentially arranged on the outer circumference of the tip part of the catheter body along the axial direction of the catheter body, wherein the second balloon is closer to the tip of the catheter body than the first balloon; an inner cavity channel, a first catheter side cavity channel and a second catheter side cavity channel which are parallel to the axial direction of the catheter body are arranged in the catheter body; the first catheter side cavity channel is communicated with a medicine adding control valve; the second catheter side cavity channel is communicated with a pressure control valve, the first balloon and the second balloon; and the catheter body is provided with catheter side holes which are positioned between the tail end of the catheter body and the first balloon and are used for enabling the inner cavity channel to be communicated with the outside, and medicine adding micro-holes which are positioned between the first balloon and the second balloon and are used for enabling thefirst catheter side cavity channel to be communicated with the outside.

The invention discloses a gas-injection thrombosis-removal device and application thereof. The gas-injection thrombosis-removal device comprises a thrombolysis catheter, a guide string, a gas pump and a suction pump. Gas-injection holes and suction holes are distributed on the front portion of the thrombolysis catheter, the gas-injection holes are communicated with gas injection channels, the suction holes are communicated with suction channels, and gas supplied by the gas pump is carbon dioxide. The gas pump fills gas into the gas injection channels in a high-frequency pulse manner, the gas is rapidly injected from the gas injection holes to smash thrombosis to be easily sucked out or to become loose to be quickly dissolved by thrombolysis medicines.

The invention relates to an automatic blood vessel thrombolysis system. The automatic blood vessel thrombolysis system is characterized by comprising a liquid medicine pushing part and a liquid medicine suction part. The liquid medicine pushing system mainly comprises a pushing pump, a pushing pipeline provided with a spiral liquid outlet, a non-return valve, a liquid medicine supplement cavity and the like, and the liquid medicine suction system mainly comprises a suction pump, a suction pipeline, a non-return valve, a discharge container and the like. When the automatic blood vessel thrombolysis system works, the liquid medicine pushing system draws thrombolysis liquid medicine, and pushes the thrombolysis liquid medicine into the pushing pipeline, and injects the thrombolysis liquid medicine to the thrombus position through the spiral liquid outlet. After a certain thrombolysis period of time, the liquid medicine suction system works, thrombus dissolved matter generated by the thrombolysis process and residual liquid medicine are absorbed by the suction pump through the suction pipeline and the non-return valve, then the suction pump pushes the thrombus dissolved matter and the residual liquid medicine to the discharge container, and a circular thrombolysis operation is completed. According to the embolism case, the above thrombolysis process is repeated. The automatic blood vessel thrombolysis system can achieve automatic operation of thrombolysis, and can control injection and suction of thrombolytics accurately, and can guarantee standardization of thrombolysis surgery.

The invention relates to a focusing ultrasonic cavitation treatment instrument which is used for treating tumor, thrombolysis, ischemic myocardium and disease of prostate based on the cavitation effect of the ultrasonic contrast agent microvesicle. The focusing ultrasonic cavitation treatment instrument comprises a main control machine, two combined treatment probes, and a B ultrasonic machine with an ultrasonic focusing ultrasonic cavitation treatment instrument function. The focusing ultrasonic cavitation treatment instrument is mainly used for the partial area of the focus, and carries out non-invasive treatment on the tumor based on the cavitation effect of the microvesicle. The microvesicle can greatly improve the cavitation effect, so that the ultrasonic focusing positioning radiation with low power can be precisely carried out in the partial area of the focus, and the cavitation effect of the microvesicle within the vessel just can be activated within the partial area, and the capillaries in the tumor can be subject to embolism and damage, so as to achieve the purpose of 'starving' the tumor. The threshold for generating the cavitation is not met by the ultrasonic energy at the periphery of the focusing area, so that the cavitation effect is not generated, so that the path where the ultrasonic wave passes or the ambient tissue can not be damaged; and the functions of the common tissue and organs are protected.