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217 results about "Troponin" patented technology

Troponin, or the troponin complex, is a complex of three regulatory proteins (troponin C, troponin I, and troponin T) that is integral to muscle contraction in skeletal muscle and cardiac muscle, but not smooth muscle. Blood troponin levels may be used as a diagnostic marker for stroke, although the sensitivity of this assay is low. Assays of cardiac-specific troponins I and T are extensively used as diagnostic and prognostic indicators in the management of myocardial infarction and acute coronary syndrome.

Turbidimetric rapid detection kit for myocardial infarction nano-immunoenhancement and use method thereof

The invention provides a turbidimetric rapid detection kit for myocardial infarction nano-immunoenhancement. The turbidimetric rapid detection kit comprises a reaction-detection integrated device, and a detection kit arranged in the reaction device, wherein a reagent R1, a reagent R2 and a calibrator are contained in the detection kit; simultaneously, quantitative detection for five important myocardial infarction-related biomarkers in one sample can be realized, and the five important biomarkers include content of troponin-I, content of D-dimer, content of myoglobin, content of hypersensitive C-reactive protein (hs-CRP) and content of heart-type fatty acid binding protein (FABP); and the turbidimetric rapid detection kit has an important clinical significance in the aspects of early diagnosis and disease course monitoring for myocardial infarction, treatment monitoring for medicines, and the like. The turbidimetric rapid detection kit provided by the invention realizes the integration of the reagents and the reaction device, and is simple, rapid and accurate to operate, high in sensitivity, strong in specificity, and low in detection cost; and the turbidimetric rapid detection kit is a detection/reagent measurement integrated kit suitable for outpatient and emergency treatment/clinical detection, and wide in instrument application range.
Owner:SUZHOU DIAGVITA BIOTECH

Immune fluorescent test strip component for quickly quantitatively detecting troponin I, detection card component comprising immune fluorescent test strip component and preparation methods for immune fluorescent test strip component and detection card component

The invention discloses an immune fluorescent test strip component for quickly quantitatively detecting troponin I, a detection card component comprising the immune fluorescent test strip component and preparation methods for the immune fluorescent test strip component and the detection card component. The test strip component comprises a test strip and an independently packaged platinum porphyrin labelled specific antibody, wherein the test strip comprises a substrate, an absorbent pad, an enveloping analysis film and a sample pad; the enveloping analysis film is provided with a detection line and a quality control line; a specific antibody enveloped by the detection line is a troponin I resistant monoclonal antibody; and a specific antibody enveloped by the quality control line is a rabbit IgG antibody. The detection card component comprises the test strip, a card box consisting of a cover plate and a back plate, and an independently packaged platinum porphyrin labelled specific antibody. An immune fluorescent rapid detection technology is adopted for detecting the level of the troponin I in a human body, the cost is low, the operation is simple, rapid and sensitive, the specificity is high, and the invention has significance for preventing cardiovascular and cerebrovascular diseases.
Owner:GUANGZHOU HONGQI OPTICAL INSTR TECH

Detection kit and preparation method thereof and detection method of troponin T

The invention belongs to the technical field of in-vitro detection, and particularly relates to a detection kit and a preparation method and application thereof. The detection kit comprises a magneticseparation reagent and an enzyme-labeled reagent; the magnetic separation reagent is prepared from troponin T antibody-coated gold magnetic particles or prepared from streptavidin-coated gold magnetic particles and a biotin-labeled troponin T antibody; and the enzyme-labeled reagent is prepared from an enzyme-labeled antibody polymer, wherein the enzyme-labeled antibody polymer is prepared from at least two enzyme-labeled antibodies and carbon bridges; the carbon bridges connect any two or more, adjacent or non-adjacent enzyme-labeled antibodies, and each carbon bridge has at least two connecting loci for connecting the enzyme-labeled antibodies; and each enzyme-labeled antibody is prepared from a detection antibody and a labeling enzyme coupled to the detection antibody, and the connecting loci are connected with the detection antibodies and/or the labeling enzymes. When chemiluminescence detection is conducted, a reaction signal value of a chemiluminescence method is amplified, thesensitivity of an antigen captured by the detection reagent can be enhanced, and the detection sensitivity is improved.
Owner:深圳天辰医疗科技有限公司

Detection and determination of the stages of coronary artery disease

A method having clinically sufficient degree of diagnostic accuracy for detecting the presence of coronary artery disease in a human patient from the general population and for distinguishing between the stages of the disease in that patient is disclosed. The stages are, first, the non-acute stage, which is either asymptomatic coronary artery disease or stable angina, second, the acute stage known as unstable angina, and, third, the acute stage known as acute myocardial infarction. The diseased state (as opposed to the non-diseased state) is indicated by the clinically significant presence of a first marker in a sample from the patient. The presence of one of the two acute stages, unstable angina or acute myocardial infarction, is indicated by the clinically significant presence of a second marker in a sample from the patient. The presence of the more severe acute stage known as acute myocardial infarction is indicated by the clinically significant presence of a third marker in a sample from the patient. Preferably the first marker comprises OxLDL, the second marker comprises MDA-modified LDL, and the third marker is a troponin. Preferably the OxLDL and MDA-modified LDL are detected using monoclonal antibodies that can detect the presence of those markers in undiluted human plasma at concentrations as low as 0.02 milligrams/deciliter.
Owner:LEUVEN RES & DEV VZW

Troponin diagnosis test paper strip for coupled immunomagnetic beads

The invention relates to a troponin diagnosis test paper strip for coupled immunomagnetic beads. The structure of the troponin diagnosis test paper strip is that an NC (nitrocellulose) film is arranged between a combined pad and an absorption pad and the NC film is an area in which a blood sample to be detected is dropped. The troponin diagnosis test paper strip is characterized in that the immunomagnetic beads are accommodated in the NC film; the immunomagnetic beads are magnetic beads with carboxyl on the surfaces, and are antibody-coupled immunomagnetic beads formed after coupling with a monoclonal antibody in an activated buffer solution. In an optimal scheme, the using amount of the antibody-coupled immunomagnetic beads and the blood sample to be detected are as follows: 4-5 microliters of 16A11 antibody-coupled immunomagnetic beads, 4-5 microliters of 810 antibody-coupled immunomagnetic beads, 2.5-3.5 microliters of blood sample to be detected, and 142-152 microliters of mixed buffer solution. The troponin diagnosis test paper strip for coupled immunomagnetic beads disclosed by the invention overcomes the defects in the prior art, so that troponin can be simply and quickly detected, the detection result is more accurate, the application field is wider, and the utilization rate for antibody raw materials is higher.
Owner:南京爱思唯志生物科技有限公司
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