The present invention relates to a method for the prognosis of a vascular event in a patient suspected of being at risk for a vascular event, said patient presenting: - no elevation of the ST segment as seen on an electrocardiogram, and / or - a normal level of at least one myocardial necrosis marker, wherein the presence and / or levels of at least two different biochemical markers are measured in a biological sample of said patient, whereby the probability that the patient will experience a vascular event is deduced from the measured presence and / or levels of the biochemical markers such as MPO, sCD40L, IL-6, PaPP-A, CRP, D-dimer, troponin, and proBNP.