Method for the prediction of vascular events and the diagnosis of acute coronary syndrome

A vascular and event technology, applied in the field of vascular events, can solve problems such as high cost of health care system

Inactive Publication Date: 2009-10-28
CENT NAT DE LA RECHERCHE SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the one hand, most of these patient admissions are often unnecessary because they are at limited risk of adverse vascular events, and unnecessary admissions impose high costs on the health care system

Method used

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  • Method for the prediction of vascular events and the diagnosis of acute coronary syndrome
  • Method for the prediction of vascular events and the diagnosis of acute coronary syndrome
  • Method for the prediction of vascular events and the diagnosis of acute coronary syndrome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0230] Example 1 - Prospective Clinical Study

[0231] Purpose

[0232] The purpose of the clinical study is to statistically evaluate the predictive value of various marker combinations by determining the sensitivity, specificity, positive predictive value, and negative predictive value of each combination. Results were validated by following vascular events (pain recurrence, patient's deterioration to unstable angina, non-fatal myocardial infarction, fatal myocardial infarction) 3-6 months after first hospitalization for chest pain to carry out.

[0233] Automated simultaneous determination of these marker combinations in a single patient sample would be particularly useful for physicians to help determine risk levels in patients with chest pain but no electrocardiogram (ECG) changes or elevated cardiac markers.

[0234] patient

[0235] At least 300 patients who were hospitalized for chest pain but had no ST-segment elevation and no elevated cardiac troponin I levels we...

Embodiment 2

[0258] Example 2 - Clinical Study

[0259] Materials and methods:

[0260] Patient Population: The study population consisted of 32 patients with suspected acute coronary syndrome (ACS) who came from the emergency department (excluding those without ACS), 22 patients with a diagnosis of unstable angina, 38 patients with acute myocardial infarction patients and 47 normal healthy volunteers. All recruited healthy volunteers and patient participants gave written informed consent.

[0261]A study approved by the institutional review board of Brabois Hospital (CentralUniversity Hospital CHU, Nancy, France) included patients with symptoms such as acute chest pain who were admitted to the emergency department with suspected acute coronary syndrome process. After admission, an electrocardiogram (12-lead ECG) and a test of cardiac troponin I blood levels (cTnI, Stratus CS troponin test, Dade Behring, USA) were performed in order to compare patients who proved unstable with those w...

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Abstract

The present invention relates to a method for the prognosis of a vascular event in a patient suspected of being at risk for a vascular event, said patient presenting: - no elevation of the ST segment as seen on an electrocardiogram, and / or - a normal level of at least one myocardial necrosis marker, wherein the presence and / or levels of at least two different biochemical markers are measured in a biological sample of said patient, whereby the probability that the patient will experience a vascular event is deduced from the measured presence and / or levels of the biochemical markers such as MPO, sCD40L, IL-6, PaPP-A, CRP, D-dimer, troponin, and proBNP.

Description

[0001] This application claims the benefit of US Provisional Application 60 / 835,903, filed August 8,2006. field of invention [0002] The present invention relates to methods of occurrence of a vascular event in a patient suspected of being at risk of a vascular event. Background of the invention [0003] Each year, millions of patients present to the hospital with symptoms such as chest pain indicating acute coronary syndrome (ACS). ACS refers to various clinical symptoms caused by acute myocardial ischemia. The identification of patients with ACS is of great importance because they are at higher risk of cardiac death or ischemic complications. [0004] Current protocols for evaluating the status of patients suspected of having ACS typically include the use of an electrocardiogram (ECG) and determination of blood levels of markers of necrosis, particularly markers of myocardial necrosis, usually cardiac troponin I or T (cTnI or cTnT) or creatine kinase (CK). [0005] Bri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68
CPCA61B5/0452G01N2800/32A61B5/14546G01N2800/324G01N33/6893A61B5/349
Inventor S·维拉尔-索西尼E·勒莫阿尔C·拉吕I·朱利亚尼
Owner CENT NAT DE LA RECHERCHE SCI
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