53 results about "Conventional chemotherapy" patented technology

A method, and system, to induce remission in diseases characterized by excess production of sTNR and interleukin 2 has been developed. In the most preferred embodiment, the system consists of antibodies to sTNFR1, sTNFR2 and sIL2R immobilized in a column containing a material such as SEPHAROSE™. The patient is connected to a pheresis machine which separates the blood into the plasma and red cells, and the plasma is circulated through the column until the desired reduction in levels of sTNFR1, sTNFR2, and IL2 is achieved, preferably to less than normal levels. In the preferred method, patients are treated three times a week for four weeks. This process can be repeated after a period of time. Clinical studies showed reduction in tumor burden in patients having failed conventional chemotherapy and radiation treatments.

The present invention is, generally, directed to the use of betulinic acid and derivatives thereof for the treatment of neuroectodermal tumors. The present invention is based on the discovery that betulinic acid and its derivatives are potent anti-neuroectodermal agents. As disclosed herein, betulinic acid and its derivatives are useful for the treatment of neuroectodermal tumors, including, due to its distinct mechanism of action, neuroectodermal tumors that are resistant to conventional chemotherapeutical agents. In addition to the new use of known compounds, the invention discloses novel compounds and pharmaceutical compositions for the treatment of neuroectodermal tumors.

A method, and system, to induce remission in diseases characterized by excess production of sTNR and interleukin 2 has been developed. In the most preferred embodiment, the system consists of antibodies to sTNFR1, sTNFR2 and sIL2R immobilized in a column containing a material such as SEPHAROSE™. The patient is connected to a pheresis machine which separates the blood into the plasma and red cells, and the plasma is circulated through the column until the desired reduction in levels of sTNFR1, sTNFR2, and IL2 is achieved, preferably to less than normal levels. In the preferred method, patients are treated three times a week for four weeks. This process can be repeated after a period of time. Clinical studies showed reduction in tumor burden in patients having failed conventional chemotherapy and radiation treatments.

A method, and system, to induce remission in diseases characterized by excess production of sTNR and interleukin 2 has been developed. In the most preferred embodiment, the system consists of antibodies to sTNFR1, sTNFR2 and sIL2R immobilized in a column containing a material such as SEPHAROSE™. The patient is connected to a pheresis machine which separates the blood into the plasma and red cells, and the plasma is circulated through the column until the desired reduction in levels of sTNFR1, sTNFR2, and IL2 is achieved, preferably to less than normal levels. In the preferred method, patients are treated three times a week for four weeks. This process can be repeated after a period of time. Clinical studies showed reduction in tumor burden in patients having failed conventional chemotherapy and radiation treatments.

The invention provides methods for predicting whether an ovarian cancer patient's tumor will be resistant to chemotherapy. The invention also provides methods for monitoring the effectiveness of treatment, particularly a chemotherapeutic treatment, in a patient treated for ovarian cancer. The invention further provides methods for treating ovarian cancer, by reducing chemotherapeutic drug resistance in said cells. In addition, the invention provides methods of screening compounds to identify tumor cell growth inhibitors in tumor cells resistant to conventional chemotherapeutic treatment regimes.

The invention discloses an exosome-nucleic acid aptamer liposome composite drug carrier system which comprises an anti-tumor medicine, wherein the surface of the anti-tumor medicine is wrapped by nano-liposomes, a nucleic acid aptamer is connected with the surfaces of the nano-liposomes through chemical bonds to form a nucleic acid aptamer liposome on which the anti-tumor medicine is carried; thenucleic acid aptamer liposome on which the anti-tumor medicine is carried is compounded with exosome. The invention further discloses a preparation method and an application of the composite drug carrier system. The composite drug carrier system is good in targeting property, good in immune evasion property, free of cytotoxicity and not liable to be degraded by macrophage, can be applied to anti-tumor medicine chemotherapy of cancer patients, is capable of greatly improving the treatment effect of anti-tumor medicines, reducing the situations of chemotherapy effect degradation and disease reoccurrence caused by drug resistance, and alleviating the bottle neck problems of conventional chemotherapy of cancer patients, and has great application values and application prospects in intensifyingcancer treatment effects.

The invention provides the application of a paris saponin (I) and a ramification of the paris saponin (I) in the preparation of a drug for remedying the tumor. The chemical name of the paris saponin (I) is 4-O-furan Arabian glycosyl-2-O-pyran buckthorn glycosyl-beta-D-pyran glucosyl dioscorea saponin, and the molecular formula of the paris saponin (I) is C44H70O16. The drug, which is prepared by the invention, also contains a drug excipient or carrier which is allowed by the preparation. The invention is mainly applied to prepare the drugs for remedying the lung cancer and the leukaemia and has strong anticancer effect, and the animal experiment testifies that the effect of resisting the growth of the cancer cells of the paris saponin (I) is obviously better than a chemotherapeutic drug of cisplatin which is in common clinical use at present. The toxic and side effect of the paris saponin (I) is light, and the experiment of cell culture in vitro testifies that the paris saponin (I) and the ramification of the paris saponin (I) do not have obvious toxic and side effect towards the growth of the hematopoietic cells of the normal person under the quantity of an antineoplastic and are better than the normal chemotherapeutic drug.

The invention provides a method for separating leukemia stem cells from a leukemia cell strain, which comprises the following steps: firstly, subculturing human acute myelogenous leukemia cell strain KD1a cells; and secondly, separating CD34+CD38-cells by an immunomagnetic bead separation method to obtain the leukemia stem cells, wherein the leukemia stem cells can resist conventional chemotherapy and NK immunization therapy. The separation method disclosed by the invention is simple to operate, can separate a large quantity of high-purity leukemia stem cells from KG1a cells, and has an important significance for the research of the leukemia stem cells.

The invention relates to a cancer treatment curcumin compound preparation. According to the cancer treatment curcumin compound preparation, the three adverse effect-free components of curcumin, pterostilbene and delta-tocotrienol 3 serve as raw materials and are compounded at an appropriate ratio to achieve synergistic effects, thereby combining the number of anti-cancer target points and anticancer spectrum and significantly increasing the anticancer effects. Due to the fact that the curcumin can kill cancer stem cells, compared with normal chemotherapy which cannot kill the cancer stem cells, the cancer treatment curcumin compound preparation can significantly reduce cancer recurrence. The cancer treatment curcumin compound preparation is non-toxic to human body and can avoid adverse effects when applied with large dose. Meanwhile, the cancer treatment curcumin compound preparation can reduce the estimated treatment expense by a half or more compared with conventional chemotherapeutic drugs and is far lower in cost than CAR-T (chimeric antigen receptor T-cell immunotherapy, thereby having a broad application prospect in the field of cancer treatment.

The present invention relates to the application of the metabolite Tagalsin C of marine life and its homologs Tagalsins A, B, D, E, F and G in preparing medicine for treating tumor. The series of compounds has high membrane permeability and broad spectrum antitumor activity of killing human promyelocytic acute leukemia cell HL-60, human myeloma cell IM9, human acute T-cell leukemia cell Jurkat, human macrophage lymphoma cell U937, human lung cancer cell A549, etc, and no obvious injury on health human nephridium cell 293aa human liver diploid cell L02. The series of compounds may be used in preparing medicine for treating tumor, medicine with high clinical Bcl-2 expression and conventional chemotherapy resistance, and medicine for treating cancer recurrence.

The invention discloses an antibody composition for detecting multiple myeloma minimal residual diseases, a kit and application, and belongs to the technical field of blood tumor treatment effect monitoring. According to the novel flow antibody combination scheme capable of being used for MRD monitoring of myeloma patients disclosed by the invention, CD319 or CD269 and other seven antibodies (CD138 / CD38 / CD184 / CD27 / CD19 / CD56 / ckappa / clamda) are combined to form a fixed combination of two groups of antibodies; through verification of 303 cases of myeloma patients, the antibody combination is feasible, accurate, convenient and fast, can be used for MRD monitoring after conventional chemotherapeutic drug treatment, and provides a good solution for the problem that MRD monitoring is difficult after DARA treatment.

Cancers are phenotyped by analysis of the presence of immune cells, particularly T cells and dendritic cells, present in regional lymph nodes. When non-sentinel regional lymph nodes of a cancer patient are compared to normal lymph nodes, it is found that increased number of dendritic cells and decreased numbers of T cells, particularly T helper cells, correlate with a positive prognosis and disease-free survival following conventional chemotherapy.

Disclosed are methods for treating one or more mammalian cancers, and in particular, methods for treating human breast cancer employing one or more iNOS pathway-inhibitory compounds, either alone, or in combination with one or more selected antihypertensive agents, including calcium channel antagonists, either alone, and further in combination with one or more conventional chemotherapeutic or anti-cancer regimens. Also disclosed are particular therapeutic formulations including these compositions, and methods for their use in treating refractory, metastatic, and relapsed cancers, and for managing or reversing treatment resistance in human triple-negative breast cancers in particular.

The invention relates to CD146 and antibody diagnosis thereof, and an application thereof in treating triple negative breast cancers. For a first time, the invention provides that CD146 is a novel target of triple negative breast cancer, and an anti-CD146 antibody might become a novel targeting medicine for treating the disease. Therefore, the invention provides an application of CD146 or anti-CD146 antibody or a functional form of the antibody in preparing medicines used for diagnosing and / or treating triple negative breast cancers. CD146 molecules are subjected to specific high expression in triple negative breast cancer tissues, and induce the occurrences of transformation of epithelial cell to mesenchymal cell in tumor cells. Therefore, tumor invasion migration is promoted. Therefore, the mechanism for CD146 antibody to treat triple negative breast cancer is mainly that the CD146 antibody inhibits the mesenchymal cell characteristics of triple negative breast cancer, and reduces the metastasis invasion capacity thereof. Compared with common chemotherapy medicines, the anti-CD146 antibody has the advantages of low side effects and clear target. The anti-CD146 antibody does not cause whole-body side effect.

The invention discloses application of KB-R7943 or Bepridil in preparing a medicine for treating gliomas. The invention discloses a novel strategy in treating gliomas, that is, gliomas are treated byusing a sodium-calcium permutoid inhibitor KB-R7943 or Bepridil, and an old medicine has new application. KB-R7943 and Bepridil have tumor cell killing mechanisms which are completely different from those of conventional medicines, and have no drug resistance as well; in addition, both KB-R7943 and Bepridil are capable of improving sensitivity of gliomas to other common chemotherapeutic drugs; dueto adoption of the two novel medicines, prognosis of patients suffering from gliomas can be improved, the survival rate of the patients can be increased, the social burden can be alleviated, and goodprospects can be achieved for treatment on gliomas.

The invention provides an Erianin nano preparation and a preparation method and application thereof. The Erianin nano preparation comprises the following raw materials by weight: 15 to 25 parts of Erianin monomers, 20 to 30 parts of a W / O type emulsifier, 70 to 80 parts of lecithin, 10 to 20 parts of ethanol, and 45 to 55 parts of an O / W type emulsifier. The Erianin nano preparation of the invention breaks through the bottleneck of poor water solubility of the Erianin and cannot be applied clinically, focuses on preparing the poorly soluble monomeric Erianin into related nano preparations, andpushes the Erianin to a clinical application stage. The Erianin nano preparation can solve the defects of poor targetability and many adverse reactions of conventional chemotherapeutic drugs. The nano preparation prepared by the invention has good targeting to the liver of mice, and is expected to be a related targeted preparation for treating primary liver cancer.

The invention relates to a combination of compounds derived from gallic acid, with an antitumoral and antimetastatic activity via a mechanism that involves the induction of apoptosis and the immunogenic death of the tumour cells and the subsequent activation of the specific immune response. The invention also relates to a composition containing a combination of derivatives of gallic acid and pharmaceutically acceptable excipients for the production of useful medicaments in the treatment of cancer. The invention further relates to the use of said composition in a coadjuvant in conventional chemotherapy, reducing the doses of chemptherapeutic agents used in the treatment of cancer.

The invention discloses N-substituted-tetrahydropyridylindole-monoclonal antibody CD14 conjugates, and a preparation method and application thereof, belonging to the field of chemical biomedicine. The structure of the conjugates is disclosed as Formula (II): under the action of a condensing agent DCC, the amino acid residue at the C terminal in the CD14 monoclonal antibody molecule is combined with sec-amino group on the indole ring in N-substituted-tetrahydropyridylindole compounds (I) to obtain the monoclonal antibody CD14 conjugates with General Formula (II). The conjugates disclosed as Formula (II) can efficiently inhibit leukaemia K562 cell proliferation, and the IC50 value for inhibiting leukaemia K562 cell proliferation is obviously lower than that of the conventional chemotherapeutic drug 5-fluorouracil (5Fu); and the conjugates disclosed as Formula (II) have low toxicity for mouse normal marrow cells, and can be used for preparing drugs for treating leukaemia.

Disclosed is a novel vaccine against Escherichia coli (E. coli) responsible for urinary tract infections. The vaccine is a recombinant chimeric protein which is prepared by linking by genetic recombination a gene encoding an antigenic determinant of uropathogenic E. coli to a CTXA2B gene encoding nontoxic A2 and B subunits of Vibrio cholerae cholera toxin (CTX) or a LTXA2B gene encoding nontoxic A2 and B subunits of E. coli heat-labile enterotoxin, wherein a translation product of the CTXA2B or LTXA2B gene serves as an immunogenic adjuvant stimulating mucosal immune responses, expressing the resulting recombinant gene in E. coli, and isolating and purifying an expressed recombinant fusion protein. The recombinant chimeric protein is useful as an oral vaccine with mild side effects and excellent vaccination efficiency against uropathogenic E. coli. Thus, the chimeric vaccine protein can remarkably reduce recurrence of urinary tract infections, prevent occurrence of antibiotic-resistant bacteria, and replace the conventional chemotherapy for urinary tract infections. Also, the chimeric vaccine protein has other advantages of being capable of being produced and commercialized in a short period with relatively low costs, and being easily modified by replacing its genetic constituents with other genes to provide various vaccines.

The present Invention relates to a method of treating a warm-blooded animal having acute myeloid leukemia (AML) which is resistant to conventional chemotherapy, comprising administering to said animal a therapeutically effective amount of a compound of formula (I), wherein the radicals and symbols have the meanings as defined in the specification, together or in combination with a conventional compound or compound mixture useful in AML treatment, in particular a topoisomerase II inhibitor, an antimetabolite, or an antitumor antibiotic, for simultaneous, separate or sequential use; and to a pharmaceutical composition and a commercial package comprising said combination.

The invention relates to a combination of compounds derived from gallic acid, with an antitumoral and antimetastatic activity via a mechanism that involves the induction of apoptosis and the immunogenic death of the tumor cells and the subsequent activation of the specific immune response. The invention also relates to a composition containing a combination of derivatives of gallic acid and pharmaceutically acceptable excipients for the production of useful medicaments in the treatment of cancer. The invention further relates to the use of said composition in a coadjuvant in conventional chemotherapy, reducing the doses of chemotherapeutic agents used in the treatment of cancer.

The present invention relates to the stratification and treatment of patients suffering of cancer. Due to the fact that anti-PD1 therapy targets lymphocytes and the efficiency of anti-cancer therapy is measured by the impact on the tumor cells, the inventors postulated that studying the molecular mechanisms of resistance of anti-PD1 therapy should take into consideration existing intercellular communication between lymphocytes and tumor cells. As exosomes are the carriers for the intercellular transfer of the miRNA responsible of chemoresistance, they herein investigated whether exposure of T cells to anti-PD1 therapy might promote the expression of exosomal miRNA (exomiR) causing the chemoresistance of cancer cells. Surprisingly, they found that anti-PD1 exposure of T-cell promotes an enrichment of exosomal miRNA-4315. They also noted that exosomal miRNA-4315 induced a phenomenon of apopto-resistance to conventional chemotherapies in cancer cells receiving exosomal miRNA-4315. At molecular level, they discern that the apopto-resistance phenomenon was associated with the miRNA-4315-mediated down-regulation of Bim, a pro-apoptotic protein. In cellular and mice models, they observed that the BH3 mimetic agent ABT263 circumvented this resistance. Thus, the invention relates to methods of stratification using exosomal miRNA-4315 and method of treatment of patients suffering of cancer using BH3 mimetic agent.

The invention relates to methods for predicting the clinical outcome of cancer patients, and in particular of acute lymphoblastic leukaemia (ALL) patients, in response to a therapy against ALL, preferably conventional chemotherapy, more preferably based on glucocorticoids, said methods based on the presence of particular polymorphism in genes coding for drug-metabolizing enzymes and apoptotic proteins. The invention relates as well to method for predicting the efficacy of a therapy based on conventional glucocorticoids as well as to method for personalized medicine in patients carrying said polymorphisms.

The invention provides new pharmacological approaches to the treatment of benign and malignant primary brain tumors, and specifically glioblastomas (GBM) and astrocytomas in which treatment is complicated by resistance to conventional chemotherapies. To which end the invention provides compositions and methods using modulators of intracellular nitrosative / oxidative stress and modulators DNA replication and apoptosis, with examples of specific inhibitors of neuronal and inducible NO synthetases (nNOS and iNOS) that were found to be effective either when administered alone or more effective when administered in combination temozolomide (TMZ), even in tumors displaying TMZ resistance.

The present invention relates to a repurposed antibiotic compound for the treatment of cancer with minimal nuclear gene damage and an anticancer pharmaceutical composition comprising same. Since the repurposed antibiotic compound has a therapeutic effect in a manner that targets only the mitochondria of cancer cells, the modified antibiotic compound does not cause gene degeneration unlike conventional chemotherapy which damages nuclear DNAs to kill cancer cells,, thereby preventing the recurrence of cancer. In addition, a mitochondria targeted therapy using the compound according to the present invention can effectively treat malignant tumors that are difficult to treat due to acquiring drug resistance by general anticancer treatment.

The present invention relates to an anti-avian flu traditional Chinese medicine composition, the constituent components and parts by weight are 35-45 parts of Folium Folium; 25-35 parts of Forsythia; 25-35 parts of Burdock; 15-25 parts of capillary ; Goose does not eat grass 15-25 parts; Guizhi 15-25 parts. The present invention overcomes the disability and teratogenic defects of existing chemotherapeutic drugs, and the main drugs Folium Folium, Forsythia, Arctium Fructus, capillary, goose herbivore, and cassia twig act synergistically, and have strong inhibitory effect on avian influenza virus The prescription has the effects of mediating the body's immunity and relieving symptoms, and has a significant preventive effect on bird flu diseases, and is a new type of traditional Chinese medicine for preventing and treating bird flu.

A device and method are taught for stimulating sympathetic nerves toward mitigating negative impacts to hematopoiesis. An autonomic nerve actuator and stimulator system with a graphic user interface (GUI), controller circuit which converts treatment parameters into a series of Building Block Waveforms (BBW) which are output to Current / Voltage Driver Circuitry (CDC) whose electrical stimulus (ES) outputs are coupled to one or more electrodes and / or electrode arrays positioned proximal specific nerve situations. The use of this in combination with conventional chemotherapy treatments, such as use of carboplatin, was found to significantly enhance hematopoiesis, with improvements in white and red blood cell counts, platelet concentration and hemoglobin concentration, in addition to other measurable characteristics which increased survival rates in the experimental groups tested.

The invention discloses tetrahydropyridinopyran-monoclonal antibody CD14 conjugates with anti-tumor activity and a preparation method and use thereof. The structure of the conjugate is represented by a formula (II). Under the action of dicyclohexylcarbodiimide (DCC) serving as a condensing agent, an amino acid residue on the carbon terminal of a CD14 monoclonal molecule is bonded with an amino on a pyran ring in a tetrahydropyridinopyran derivative to form a monoclonal antibody conjugate CD14-TPP of the formula (II). CD14-TPP can effectively inhibit the proliferation of a human erythroleukemia cell line K562, an ovarian cancer cell line MDR-MB-231 and a liver cancer cell line SMMC-7721 with an IC50 value much lower than 5-fluorouracil (5Fu) which is a conventional chemotherapy medicine. The conjugate of the formula (II) with low toxic effect on normal bone narrow cells of mouse can be used for preparing medicines for treating leukemia, ovarian cancer and liver cancer.

The invention relates to the application of marine biological metabolite Tagalsin C and its homologues Tagalsins A, B, D, E, F, G in the preparation of antitumor drugs. This series of compounds has membrane permeability and broad-spectrum anti-tumor activity, and can kill human promyelocytic acute leukemia cells HL-60, human myeloma cells IM9, human acute T-cell leukemia cells Jurkat, and human macrophage lymphoma cells U937, human lung cancer cell A549, human breast cancer cell MCF-7 and MDA-MB-231, human liver cancer cell HepG2, human prostate cancer cell PC-3 and human cervical cancer epithelial cell Hela, while normal cell human kidney blast 293 And the human liver diploid cell L02 has no obvious killing ability, and can be applied to the preparation of drugs for treating tumors, drugs for treating clinical high expression of Bcl-2, resistant to conventional chemotherapy, and drugs for treating recurrent cancer.

The invention discloses an application of PGC-1[alpha] specific RNA interfering adenovirus in reducing leukemia cell drug resistance. The PGC-1[alpha] specific RNA interfering adenovirus provided by the invention can enhance the sensitivity of acute myeloid leukemia cells to conventional chemotherapeutic drugs (an apoptotic cell proportion is increased from a range of 22.7-27.7% to a range from 40.3-50.5%), so that the survival time of a disease animal model can be obviously prolonged; taking a leukemia mouse model, which is prepared by virtue of OCI-AML3 cells, as an example, the average survival time of a leukemia mouse, under the circumstance of accepting conventional chemotherapy, is 37.9 days; and on the basis of the conventional chemotherapy, and in combination with PGC-1[alpha] specific RNA interfering adenovirus treatment, the average survival time of the mouse exceeds 45 days, which is prolonged by more than 20%.