1148 results about "Pyran" patented technology

The invention relates to the technical field of organic synthesis, in particular to a method for constructing Orforglipron pyran ring chirality through enzyme catalysis, which comprises the following steps: step S1, taking SM1 and SM2 as raw materials, and reacting under the action of a palladium catalyst and a ligand to obtain INT-1; step S2; carrying out hydrogenation reduction on double bonds of the INT-1 under the catalysis of Pd / C to obtain INT-2; s3, carrying out hydrolysis resolution on the INT-2 in a solvent, a buffer salt system and enzyme catalysis to obtain a chiral pure intermediate INT-3; step S4, performing ring closing on the INT-3 through a Grignard reaction to synthesize a lactone intermediate INT-4; and S5, carrying out Diball-H reduction, quenching, dichloromethane extraction and anhydrous sodium sulfate drying on the INT-4, and then reducing by using triethyl silane to obtain the compound with the general formula A. Chirality is constructed through enzyme catalysis, isomer impurities do not need to be split and separated through SFC when the chirality is constructed, loss is reduced, the yield is increased, and a target product is obtained with high yield and high chiral selectivity; meanwhile, the cost is relatively reduced, and the cost is saved.

The invention discloses a preparation method of 3, 4-difluoro-2-methoxyphenylacetic acid, and belongs to the technical field of organic synthesis. The preparation method comprises the following steps: reacting 2, 3-difluorophenol with 3, 4-dihydropyran under the action of sulfonic acid resin to generate an intermediate 2-(2, 3-difluorophenoxy) pyran; then lithiating, reacting with tert-butyl 2-bromoacetate, and performing acidolysis to obtain a 3, 4-difluoro-2-hydroxyphenylacetic acid intermediate; and finally reacting with a methylation reagent in the presence of alkali to generate the target compound 3, 4-difluoro-2-methoxyphenylacetic acid. The preparation method has the advantages that the route is overall reasonable, the preparation method comprises three steps, and a simple and effective new route is provided for the preparation of the 3, 4-difluoro-2-methoxyphenylacetic acid.

The present invention relates to a preparation method of an intelligent self-repairing, flame-retardant and light-resistant water-based polyurethane coating. The method comprises the following steps: preparing a self-made hyperbranched flame retardant and using it in the synthesis of a polyurethane prepolymer; cooling the mixture to 58° C., adding 2,2-dimethylolpropionic acid, reacting the mixture for 1 to 2 hours, adding 1 to 2 parts of a disulfide compound, reacting the mixture for 1 to 2 hours at 60 to 80° C., adding 1 to 2 parts of a hydrogen bonding agent, reacting the mixture for 1 hour at 60 to 80° C., adding 0.5 to 1.5 parts of a coumarin derivative, and reacting the mixture for 60 to 90° C. The mixture was stirred for 1-2 hours, and then spiropyran, diethanol monoisopropanolamine, and 0.01 parts of p-toluenesulfonamide were added, and the mixture was reacted at 50°C for 30 minutes. The temperature was lowered to 40-45°C, and 1-2 parts of triethylamine were added, and the mixture was reacted for 1-2 hours. The mixture was cooled to room temperature, and 60-65 parts of water were added. The mixture was stirred at a speed of 1800-2000 r / min for 0.5-1 hour to obtain an intelligent self-healing, flame-retardant, and light-resistant water-based polyurethane coating. The flame retardancy and self-healing properties of the obtained water-based polyurethane were significantly improved.

According to the method, phosphomolybdic acid, copper chloride and ferric chloride serve as precursors, copper and iron-containing phosphomolybdic acid nano-enzyme (Cu, Fe-PMs) with peroxidase-like activity is synthesized through a microwave method, under the acidic condition, on one hand, the surface of Cu and Fe-PMs carries negative charges, high affinity is generated between Cu and Fe-PMs and a substrate TMB with positive charges, and on the other hand, the surface of Cu and Fe-PMs has negative charges; on the other hand, Cu / Fe / Mo three-metal redox couple accelerates the regeneration of Fe < 2 + > and plays an important role in the activity of peroxidase, and meanwhile, due to the introduction of sodium dehydroacetate, Cu and Fe in Cu and Fe-PMs and pyranoid ring and keto O in sodium dehydroacetate interact through coordinate bonds to cause electron interaction, so that the peroxidase-like activity of Cu and Fe-PMs is enhanced, and the peroxidase-like activity of Cu and Fe-PMs is improved. And the Fenton reaction is enhanced through transfer of electrons among the sodium dehydroacetate, the Cu and the Fe-PMs. When Cu and Fe-PMs oxidize TMB and H2O2, sodium dehydroacetate enhances the absorbance of the system, and on the basis, a novel colorimetric rapid detection method of sodium dehydroacetate is established.

The invention discloses an antibacterial material rich in a bismuth metal organic framework and a preparation method thereof, the method comprises the following steps: adding an indole monomer and an alcohol monomer into a solvent, and then adding nitrosalicylaldehyde into the solvent to obtain a spiropyran compound; the preparation method comprises the following steps: adding humic acid into a binary solvent consisting of dioxane and butanol to obtain a mixed solution; the ratio of the mass of the humic acid to the volume of the binary solvent is (2-3): (20-40) g / ml; sequentially adding a bismuth source, 2-bromo-5-(trifluoromethyl) pyridine and 4-(trifluoromethyl) phenylboronic acid into the mixed solution to obtain a bismuth metal organic framework; and adding the spiropyran compound into the bismuth metal organic framework to obtain the antibacterial material rich in the bismuth metal organic framework. The antibacterial capability of the antibacterial material is improved.

The invention discloses a pyranopyridine compound as well as a preparation method, a pharmaceutical composition and application thereof. The invention provides a compound as shown in a formula (I), a pharmaceutically acceptable salt or a stereoisomer thereof, and the compound has a relatively strong inhibition effect on aldosterone synthetase, almost has no influence on cortisol synthetase, has high selectivity and relatively high safety, and can be used for preventing and / or treating various diseases related to aldosterone. # imgabs0 #

The present invention provides the synthesis and application of a group of multiple stimulus-responsive aggregation-induced emission enhancement probes, belonging to the field of aggregation-induced emission materials. Through a simple three-step method, a D-π-A type molecular skeleton is constructed in the molecule, and a group of pyranone-type aggregation-induced emission enhancement probes are synthesized. This group of probes can undergo non-interfering changes in fluorescence color or intensity under multiple stimuli such as solvents, pressure, humidity, and pH. On the one hand, it makes up for the relatively single variety of AIE template molecules; on the other hand, it breaks through the technical barrier of single response of aggregation-induced emission probes, realizing the possibility that the same molecule can simultaneously respond non-interferingly to multiple external stimuli. The preparation method of this probe is simple, with high yield and sensitive and rapid fluorescence response, and is suitable for various application needs.

The invention provides a carbonyl reductase mutant and an application of the carbonyl reductase mutant in synthesis of S-glassine. The mutant protein is a non-natural protein, and the mutant protein can significantly improve the activity of catalyzing the reduction of carbonyl in 1-C-(beta-D-xylopyranosyl)-acetone to generate S-configuration alcohol. When the activity-improved carbonyl reductase mutant strain is applied to the production process of S-configuration glassine, the carbonyl reduction capacity of the S-configuration glassine can be improved, 100-240 g / L of substrate can be completely converted, and the S-configuration glassine is generated.

The invention provides an organic electroluminescent material and an organic electroluminescent device, the organic electroluminescent material has the following structure: M (LA) 2 (LB), the organic electroluminescent device provided by the invention adopts a doping material with a specific atomic structure, and one or more benzene ring groups are thickened on a benzopyran or benzothiapyran ring, so that the organic electroluminescent device can be used for preparing the organic electroluminescent device. By adjusting the size and shape of the spatial structure of the obtained substance, the molecular spatial configuration of the compound is extended, the electrochemical property of the compound is adjusted, and the symmetric dipole moment between molecules is improved, so that after the obtained organic compound is applied to the organic electroluminescent device, the device has the characteristics of long service life, high efficiency and low driving voltage.

The invention discloses a near-infrared dichroic dye, a liquid crystal composition and application of the near-infrared dichroic dye and the liquid crystal composition. The structural general formula of the disclosed dichroic dye is as shown in formula I in the specification. According to the invention, a hydrogenated quinoline ring, a hydrogenated benzopyran ring and a hydrogenated naphthalene ring are introduced into a molecular skeleton, so that the novel near-infrared dichroic dye with high light stability, high solubility, high order parameter and high light modulation capability is obtained. Compared with the near-infrared dichroic dye disclosed in the prior art, the absorption band is further subjected to red shift, and the light modulation capability is remarkably improved; ordering parameters are greatly improved, and the application bottleneck is solved.

The invention discloses a low-concentration ether electrolyte adaptive to a high-voltage high-nickel ternary lithium ion battery, a preparation method of the low-concentration ether electrolyte and the lithium ion battery, and relates to the technical field of batteries. The ether electrolyte comprises a solvent and a solute; the solvent comprises an ether solvent, and is specifically at least one of 4-cyano tetrahydropyran, 2-(tetrahydro-2H-pyran-4-yl) acetonitrile, 2-methoxyacetonitrile, 2-ethyoxyl acetonitrile, 3-methoxypropionitrile, 3-ethyoxyl propionitrile, 3-butoxyl propionitrile, ethylene glycol bis (propionitrile) ether and 3-{2-[2-(2-cyano ethyoxyl) ethyoxyl] ethyoxyl} propionitrile. The ether solvent contains cyano groups, the strong electronegativity of the cyano groups enables the cyano groups to be coordinated with transition metal ions in the ternary material, and the cyano groups are preferentially adsorbed at the interface of the positive electrode material, so that the arrangement of solvent molecules at the interface has directivity, the proportion of ether oxygen bonds and carbon hydrogen atoms in double electric layers is reduced, and the performance of the positive electrode material is improved. And the sites which are easy to generate dehydrogenation reaction in the molecules are far away from the high-voltage positive electrode interface which is easy to generate oxidation reaction.

The invention discloses a method for analyzing and identifying anti-inflammatory active ingredients of Xinhuang tablets based on a UPLC-Tripe-TOF-MS (Ultra Performance Liquid Chromatography-Tripe-TOF-Mass Spectrometry) spectrum-effect relationship. According to the method, an active extract is obtained from Xinhuang tablets through a dichloromethane liquid-liquid extraction method, a fingerprint spectrum of 10 batches of samples is established by using UPLC-Tripe-TOF-MS, a double-target evaluation system is constructed by combining an LPS-induced RAW264.7 cell inflammation model and COX-2 enzyme inhibition detection, and spectrum-effect relationship research is performed through gray correlation analysis and an OPLS-DA data mining technology. Four chemical components, namely indomethacin, 7-ketolithocholic acid, erucyl amide and pyranoapigenin, which are highly related to the anti-inflammatory activity are identified; the quality control method of the Xinhuang tablets based on the key chemical markers is established, a scientific basis is provided for quality evaluation and standardization of the traditional Chinese medicine compound Xinhuang tablets, and meanwhile a new thought is provided for development of anti-inflammatory drugs.

Disclosed herein are a solid Form of a TYK2 inhibitor N-(5-(2,2-dimethyl-2,3-dihydro-[1,4]dioxino[2,3-b]pyridin-6-yl)-4-((6-(methylsulfonyl)-4-(tetrahydro-2H-pyran-4-yl)pyridin-2-yl)amino)pyridin-2-yl)acetamide per se and the pharmaceutically acceptable salts of the TYK2 inhibitor or crystalline Forms of the salts, pharmaceutical compositions comprising the crystalline Form or the salts or the salts in crystalline Forms, the processes for preparing the crystalline Form or the salts or the salts in crystalline Forms, and methods of use therefor.

The invention relates to the technical field of organic functional materials, in particular to a near-infrared second-region cyanine dye molecule as well as a preparation method and application thereof, the structural formula of the near-infrared second-region cyanine dye molecule is shown as a formula I or a formula II: # imgabs0 #, the cyanine dye molecule is modified by benzopyranium, the excitation wavelength and the fluorescence emission wavelength of the near-infrared second-region cyanine dye molecule both reach the near-infrared second region, and the near-infrared second-region cyanine dye molecule is a near-infrared second-region cyanine dye molecule. Strong absorption and emission are shown in a near-infrared second region, and the Stokes shift is greater than 50nm; the synthetic method of the fluorescent dye is simple, raw materials are easy to obtain, and the yield is high; the cyanine dye disclosed by the invention is excellent in photo-thermal stability and good in photo-thermal imaging effect, has a good phototherapy effect and has a great potential application prospect in the field of tumor treatment.

The present invention relates to a process for preparing N-hydroxypyridone compounds (I) from pyrone compounds using a phase transfer catalyst. # imgabs0 #

The present invention relates to a method for preparing dihydroxyammonium 5,5′-bistetrazole-1,1′-diolate. The method for preparing dihydroxyammonium 5,5′-bistetrazole-1,1′-diolate, according to one embodiment of the present invention, comprises the steps of: synthesizing 5,5′-bistetrazole-1,1′-diol dihydrate (1,1′-BTO) from ditetrahydropyranyl diazidoglyoxime (THP-DAG) by using a hydrochloric acid (HCl) solution in a first solvent; and reacting 1,1′-BTO with an amine solution so as to neutralize same and, simultaneously, obtaining dihydroxylammonium 5,5′-bistetrazole-1,1′-diolate (Thomas Klapotke explosive-50, TKX-50).

The present invention relates to a pharmaceutical composition for oral administration, for example in the form of a tablet or a powder suitable to be filled into a capsule shell, comprising 2-(isoindolin-2-ylmethyl)-5-((1-(methylsulfonyl)- piperidin-4-yl)methoxy)-4H-pyran-4-one (I) or a pharmaceutically acceptable salt thereof as an active ingredient. Compound (I) or a pharmaceutically acceptable salt thereof is a selective inhibitor of CYP11A1 enzyme and is useful in the treatment of hormonally regulated diseases such as cancer including prostate cancer and breast cancer.

The invention relates to the technical field of organic synthesis, in particular to a method for constructing Orforglipron tetrahydropyran ring chirality through enzyme catalysis, which comprises the following steps: step S1, taking SM1 as a raw material, and carrying out hydrolysis resolution in a solvent, a buffer salt system and enzyme catalysis to obtain a chiral pure intermediate INT-1; step S2; performing ring closing on the INT-1 through Grignard reaction to synthesize a lactone intermediate; s3, carrying out Diball-H reduction, quenching, dichloromethane extraction and anhydrous sodium sulfate drying on the INT-4, and then reducing the INT-4 by using triethyl silane to obtain an intermediate INT3; step S4, coupling the INT-3 in the presence of a catalyst and a ligand to obtain an intermediate INT-4; step S5, carrying out deprotection and salification on the INT-4 to obtain an intermediate INT5; s6, closing an indole ring from INT5 to obtain a compound of which the general formula is A; chirality is constructed through enzyme catalysis, isomer impurities do not need to be split and separated through SFC when the chirality is constructed, the loss is reduced, the yield is increased, and a target product is obtained with high chiral selectivity; meanwhile, the cost is relatively reduced, and the cost is saved.

The invention relates to the technical field of organic synthesis, and provides a preparation method of alkylpyran-3, 5-difluorobenzene, which comprises the following steps: S1, adding a Grignard reagent into an alkylpyrone solution, reacting for the first time, quenching for the first time, separating liquid to obtain an organic phase, adding acidic resin into the organic phase, refluxing, and filtering to obtain filtrate containing alkylpyranene chlorobenzene, sequentially adding tetramethyldisiloxane and methanesulfonic acid into the filtrate containing the alkylpyran chlorobenzene, and carrying out a second reaction to obtain alkylpyran chlorobenzene; s2, adding alkylpyran chlorobenzene, 3, 5-difluorophenylboronic acid and an acid-binding agent into the solvent, stirring, adding a catalyst, and carrying out a third reaction to obtain alkylpyran 3, 5-difluorobenzene; the Grignard reagent is prepared from magnesium chips and p-chlorobromobenzene. According to the technical scheme, the problems of high preparation cost and low purity and yield of the alkylpyran 3, 5-difluorobenzene in the prior art are solved.

Provided herein is a process for the preparation of (R)—N-(5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)-1-methyl-1H-pyrazole-4-carboxamide, intermediates thereof, and salts of the foregoing.

The invention discloses a method for synthesizing branched polyester by using polyester and a carbon dioxide derivative and a product thereof. The method comprises the following steps: carrying out solid-phase ester exchange reaction on a carbon dioxide derivative and polyester under inert gas protection and heating conditions to obtain branched polyester; the carbon dioxide derivative is prepared from at least one of 3-ethylidene-6-vinyl tetrahydro-2H-pyran-2-ketone and a homopolymer pEVL (Poly (Ethylene Vinyl Vinyl) L) thereof. According to the invention, a large amount of polyester materials and carbon dioxide wastes can be utilized, so that the current relatively difficult problems of carbon emission and pollution are solved.

A carbon sorbent for removing carbon dioxide from a gaseous material includes a surface composition including carbon, nitrogen, and oxygen. The nitrogen atoms at the surface of the carbon sorbent may be present in pyridone, pyrrole, and pyridine. The surface of the carbon sorbent may include lactone groups and pyrone groups. The carbon sorbent may have a bulk density greater than about 0.40 grams per cubic centimeter. The carbon sorbent may be formed using amino acids to provide the nitrogen for the carbon sorbent. In addition, the use of processing aids during the formation of the carbon sorbent facilitates the formation of a denser carbon sorbent. Related methods of forming the carbon sorbent and pellets of the carbon sorbent are also disclosed.

A polishing liquid for CMP, containing: abrasive grains; an additive; and water, in which the abrasive grains include cerium-based particles, a zeta potential of the abrasive grains is negative, the additive includes (A1) a 4-pyrone-based compound represented by General Formula (1) below, and a pH is 5.0 or more. A polishing liquid for CMP, containing: abrasive grains; an additive; and water, in which the abrasive grains include cerium-based particles, a zeta potential of the abrasive grains is negative, the additive includes (A2) a picolinic acid compound, and a pH is 5.0 or more.[In the formula, X11, X12, and X13 are each independently a hydrogen atom or a monovalent substituent.]

The invention provides a preparation method of a (S)-5-(2, 2-dimethyl tetrahydro-2H-pyran-4-yl)-N-methyl-N-phenyl-1H-indole-2-formamide compound, which comprises the following steps: by taking a compound 1 as an initial raw material, reacting the compound 1 with a boric acid ester reagent to obtain a boric acid ester compound 2; the method comprises the following steps: by taking a compound 3 as an initial raw material, reducing carbonyl through enzyme catalysis to obtain a compound 4, then protecting alcoholic hydroxyl through a sulfonylation reagent to obtain a compound 5, and finally, directly coupling the compound 5 with a compound 2 under the action of a catalyst to obtain a target product compound 6. The whole process is low in experimental condition requirement, simple to operate, high in yield and suitable for process amplification.

This disclosure provides redox cyclable molecules for energy storage. These molecules belong to either the 4H-pyran-4-ylidene family or include a six-membered aromatic ring with one nitrogen atom at position 1 (pyridinium family) or two nitrogen atoms at positions 1 and 4 (pyrazinium family) or at positions 1 and 3 (pyrimidinium family). Molecules in these families are used as analytes in redox flow batteries.

A carbon sorbent for removing carbon dioxide from a gaseous material includes a surface composition including carbon, nitrogen, and oxygen. The nitrogen atoms at the surface of the carbon sorbent may be present in pyridone, pyrrole, and pyridine. The surface of the carbon sorbent may include lactone groups and pyrone groups. The carbon sorbent may have a bulk density greater than about 0.40 grams per cubic centimeter and may exhibit a carbon dioxide capacity of at least 11.0 weight percent at 30° C. and 760 mmHg. The carbon sorbent may be formed using amino acids to provide the nitrogen for the carbon sorbent. In addition, the use of processing aids during the formation of the carbon sorbent facilitates the formation of a denser carbon sorbent. Related methods of forming the carbon sorbent and pellets of the carbon sorbent are also disclosed.

Disclosed herein is a solid Form A of 1-(6-ethyl-8-fluoro-4-methyl-3-(3-methyl-1,2,4-oxadiazol-5-yl)quinolin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)piperidin-4-amine hydrochloride exhibiting at least X-ray lines (in degrees 2θ ± 0.2) at 4.30, 8.59, 12.88, 18.82 and 21.34 in a powder diffraction pattern when measured using Cu Kα radiation. The solid Form A is an antagonist of the kappa-opioid receptor (KOR) and is useful for treating conditions that benefit from the same. Compositions comprising the solid Form A, as well as related methods of use are also disclosed.

The present invention relates to the technical field of organic synthesis, and specifically relates to a method for constructing the chirality of a pyran ring in Orforglipron by means of enzymatic catalysis, the method comprising the following steps: step S1, by using SM1 and SM2 as starting materials, carrying out a reaction under the action of a palladium catalyst and a ligand to obtain INT-1; step S2, under the catalysis of Pd / C, subjecting INT-1 to double bond hydrogenation reduction to obtain INT-2; step S3, in the presence of a solvent, a buffer salt system and enzymatic catalysis, subjecting INT-2 to hydrolysis and resolution to obtain a chirally pure intermediate INT-3; step S4, subjecting INT-3 to a Grignard reaction for cyclization, so as to synthesize a lactone intermediate INT-4; and step S5, subjecting INT-4 to reduction by means of Dibal-H, quenching same, performing extraction with dichloromethane, drying same with anhydrous sodium sulfate, and then performing reduction by means of triethylsilane to obtain a compound of general formula A. In the present invention, the chirality is constructed by means of enzymatic catalysis without the need of SFC resolution for separating isomeric impurities during the construction of the chirality, thereby reducing losses and improving yield, obtaining the target product at high yield and high chiral selectivity, and further saving expenses and reducing costs.

The present invention relates to the use of compound of formula (I) as an aroma chemical to impart a fresh note, citrus note, white floral note, fruity note, herbal note, rose leaf note, steamy green note, carrot route note, woody note, pencil shaving note, remains of rose oxide note or any combination of two or more of these impressions to composition and also for enhancing and / or modifying the aroma of a composition. The present invention is further directed to a composition comprising at least one compound of formula (I) and (i) at least one aroma chemical different from the compound of formula (I) or (ii) at least one non-aroma chemical carrier, or (iii) both (i) and (ii).