62 results about "Benzamide" patented technology

This invention relates to the fields of pesticide formulations and pesticide pest control, specifically to a composite nano-slow-release suspension of emamectin benzoate and chlorantraniliprole, its preparation, and application. The nano-slow-release suspension comprises emamectin benzoate, chlorantraniliprole, a nanocarrier, a wetting agent, a dispersant, a synergist, a thickener, an antifoaming agent, an antifreeze, a preservative, and water. The nanocarrier is an NX-CMCS & MOF composite nanocarrier. Spraying this composite nano-pesticide onto crops improves the adhesion and penetration of the pesticide on leaves, enhances its resistance to rain washout, and effectively kills major crop pests such as bollworms, diamondback moths, cowpea thrips, and rice planthoppers. Compared with traditional pesticide formulations, it has a significant effect of reducing dosage and increasing efficacy, and has broad application prospects in the field of agricultural pest control and promoting green agriculture.

The present invention relates to use of a pharmaceutical composition for multiple myeloma containing 5-fluoro-2-[(4-{7-[(1S,3S,4R)-5-methylidene-2-azabicyclo[2.2.2]octane-3-carbonyl]-2,7-diazaspiro[3.5]nonan-2-yl}pyrimidine-5-yl)oxy]-N,N-di(propan-2-yl)benzamide.

The present application belongs to the technical field of pesticides, and particularly relates to an insecticidal composition containing an isoxazoline-substituted benzamide compound and application thereof. The insecticidal composition contains active ingredient A and active ingredient B, wherein the active ingredient A is oxadiazylfluazaim or the active ingredient B is one or more selected from the following compounds: fluoromethane sulfide, pyridaben and fluoromethane bisether. The composition has reasonable components, good insecticidal effect, low pesticide cost, and the characteristics of reducing the application amount, being safe to crops, reducing the amount of pesticide residues, etc.

The application belongs to the technical field of chemical medicine raw materials, and particularly relates to a benzamide piperazine derivative, a preparation method and application thereof. The structure of the compound is shown as formula I. It is verified through experiments that the compound provided by the application has good TRPC6 channel inhibition effect, and the compound provided by the application is a novel TRPC6 channel small molecule inhibitor in structure, which lays a foundation for the development of a drug for treating or preventing diseases related to TRPC6 channel-mediated calcium ion influx abnormalities.

This invention discloses a polyvinyl alcohol-modified multifunctional powder slump retainer and its preparation method. The preparation method is as follows: First, polyvinyl alcohol is etherified with p-halogenated benzoic acid to prepare a carboxyl-containing intermediate; second, the carboxyl-containing intermediate is amidated with an amino-terminated modified polyether to prepare a long-side-chain intermediate; then, the long-side-chain intermediate is activated by ortho-C-H oxidation with benzamide, and then coupled with a functional alkyne to form a ring to construct a functional group, thus preparing the target slump retainer; finally, the slump retainer is sliced ​​and pulverized using a slicer and a pulverizer, respectively, to obtain the powder slump retainer. This method uses widely available raw materials, and the preparation process is simple and safe; the product has a long shelf life; the product contains no anti-caking agents and other components, and has a fast dissolution rate, which can significantly reduce transportation costs; the product also has advantages such as antibacterial properties, reduced concrete shrinkage in the later stages, and high water retention; and the product has stable performance and can be stored for a long time.

The application provides an intermediate for synthesizing chlorantraniliprole and cyantraniliprole and a preparation method of the intermediate, and the structural formula of the intermediate is 2-amino-3-methylbenzoic acid. The intermediate is obtained by a -D-A reaction, aromatization and a Hoffmann elimination reaction from a cheap bio-based platform compound 2-methylfuran as a starting material. The whole process does not need a dangerous nitration process and a hydrogenation process, the process has mild reaction conditions, good operability, less wastewater and a high yield of the obtained intermediate, and is very suitable for industrialized preparation of an intermediate required by the high-efficiency insecticides chlorantraniliprole and cyantraniliprole.

A 2-[2-({12,12-dimethyl-4-oxo-6-phenyl-3,11-dioxatricyclo[8.4.0.0,2,7]tetradeca-1,5,7,9-tetraen-8-yl)oxy)acetamidolbenzamide compound and related derivatives, as well as the use thereof in the preparation of a medicament for treatment and / or prevention of diseases or disorders associated with the circadian rhythm are provided. The compound of the invention is a CLOCK-binding small molecule and also an inhibitor of CLOCK:BMALl interaction, and is therefore useful, as pharmaceutical agent, especially in the treatment and / or prevention of disorders associated with the circadian rhythm.

The application provides a kind of 3, 4-dichloroisothiazole benzamide derivatives and preparation method and purposes thereof, specifically relates to a kind of derivatives, and the chemical structure general formula is seen formula I: the application discloses the general formula of the structure of the above compound, synthesis method and as insecticide, acaricide, fungicide, anti-plant virus agent, plant activator purposes, it is combined with agricultural acceptable adjuvant or synergist and with commercial insecticide, acaricide, fungicide, anti-plant virus agent, plant immune activator in the prevention and treatment of agricultural, forestry, horticultural plant pest, mite damage, disease, viral disease purposes and preparation method.

The present invention relates to the use of a pharmaceutical composition against multiple myeloma, the composition comprising 5-fluoro-2-[(4-{7-[(1S,3S,4R)-5-methylidene-2-azabicyclo[2.2.2]octane-3-carbonyl]-2,7-diazaspiro[3.5]nonan-2-yl}pyrimidin-5-yl)oxy]-N,N-di(propan-2-yl)benzamide.

This invention relates to the field of organic synthesis technology, specifically disclosing a method for preparing N-(2,4-diaminophenyl)-4-aminobenzamide. The method involves using N-(2,4-dinitrophenyl)-4-nitrobenzamide as a raw material, adding a catalyst, buffer salt, and water, mixing the mixture, and then purging with nitrogen gas to maintain pressure. The nitrogen gas is then replaced with hydrogen gas, and a hydrogenation reaction is carried out under a hydrogen atmosphere. After the reaction is complete, an acid is added to quench the reaction, the catalyst is removed by filtration, and then an alkali is added to adjust the pH to above 8. The mixture is then filtered to obtain crude N-(2,4-diaminophenyl)-4-aminobenzamide. The crude product is purified by recrystallization and finally dried to obtain N-(2,4-diaminophenyl)-4-aminobenzamide. The method provided by this invention has high selectivity, few side reactions, protects the amide bond from hydrolysis, and produces a product with high purity.

The present disclosure relates to a fungicide composition. More particularly, the present disclosure relates to a liquid fungicide composition comprising a benzamide fungicide and a combination of surfactants. The present disclosure also relates to a process for preparing the fungicide composition and a method for controlling growth of fungal phytopathogens using the same.

The present invention relates to a compound of formula (I) as inhibitors of calcium calmodulin dependent protein kinase 2 (CAMK2) for the treatment of for the treatment of heart failure, fibrosis, cardiomyopathies, atrial fibrillation, catecholaminergic polymeric ventricular tachycardia, heart block, cardiac arrhythmias, contraception, anxiety, post-traumatic stress disorder, hypertension, tachycardia, diabetes, allergy, and asthma.

The present invention relates to (R)-4-[5-(4-chlorophenyl)-1-[2-(trifluoromethyl)-phenyl]pyrrol-2-yl]-N-[2-(dimethylamino)-ethyl]benzamide (+)-L-tartrate salt, methods for its preparation, pharmaceutical compositions containing it and its use in treating diseases such as cancer.

The present invention relates to sulfonimidoylbenzamide of formula (I) as a herbicide. In chemical formula (I), X, W, Z, R, R' and R'' represent radicals such as alkyl, cycloalkyl, haloalkyl and halogen radicals.

This invention discloses a benzamide / benzenesulfonamide compound containing an aryl butanone structure, its preparation method, and its application, belonging to the field of medicinal chemistry. The structure of the benzamide compound containing the aryl butanone structure is as follows: R1 is hydrogen, halogen, alkyl, or alkoxy; R2 is tert-butyl, tert-pentyl, tert-octyl, adamantyl, or α,α-dimethylbenzyl; R3 is hydrogen, halogen, alkyl, alkoxy, fused ring, or aryl; R4 is hydrogen, alkyl, or aryl. The structure of the benzenesulfonamide compound containing the aryl butanone structure is as follows: R1 is hydrogen, halogen, or alkyl; R2 is tert-butyl, tert-pentyl, or tert-octyl; R3 is hydrogen, halogen, alkyl, or fused ring. The advantages of this invention are that some of the prepared compounds exhibit strong inhibitory effects on MCF-7 and HCT-116, and can be used as lead compounds for the subsequent preparation and development of antitumor drugs.

The application discloses benzamide phenylpiperazine radioactive compounds and a preparation method and application thereof, and belongs to the field of radioactive drugs. 18 The F-labeled compound is simple in preparation method. The benzamide phenylpiperazine radioactive compound can be used as a dopamine D3 receptor targeted radioactive probe, and has the characteristics of excellent biological performance, high chemical purity and high specific activity.

Disclosed in the present invention are a γ-aminobutyric acid gated chloride ion channel allosteric modulator compound and the use thereof, i.e., (S)-4-(5-(3-chloro-5-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3-yl)-2-methyl-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)benzamide. The compound has an excellent control effect on pests such as thysanoptera, acarina and lepidoptera, is very friendly to bees, has high environmental ecological safety, can be used for preparing efficient, low-toxicity and safe insecticides, and has wide application prospects in agricultural production.

The application discloses a chlorantraniliprole reaction mother liquor recovery method and recovery processing equipment, comprising the following steps: S1: K acid and K amine are dissolved in a solvent a; S2: an acid-binding agent b is added, and temperature is controlled to drop methylsulfonyl chloride for condensation reaction; S3: after the reaction is completed, water is added to cool and crystallize; S4: centrifugation is carried out to obtain chlorantraniliprole; S5: after alkalization, the reaction mother liquor is extracted to separate an organic phase; S6: the organic phase is distilled to obtain a distillate main product; and S7: the distillate main product is dehydrated through a molecular sieve. The application has the advantages that: in the chlorantraniliprole synthesis, the selected solvent a and the acid-binding agent b can make the reaction yield greater than 94%; meanwhile, the reaction solvent a can meet the requirements of the reaction, direct separation with water, and extraction and dissolution of the acid-binding agent b in water; in the mother liquor recycling, the selected solvent a and the acid-binding agent b meet the conditions of molecular sieve dehydration, and the recovery rate of the solvent a and the acid-binding agent b is more than 95%.

The invention discloses the crystal form, preparation method and application of an alkynyl compound, its salt and solvent compound. The invention specifically discloses 3-((1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazine-1-yl)methyl)-3-(trifluoromethyl)phenyl) benzamide crystal form I and 3-((1H-pyrazolo [3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazine-1-yl)methyl)-3-(trifluoromethyl)phenyl) benzamide fumarate crystal form II. The crystal form of the invention has good stability and has important value for drug optimization and development.

The present invention relates to adamantanyl-substituted benzamide compounds and their use as antagonists of the P2X7 purinoreceptor. The invention further relates to methods for the treatment of disease and conditions associated with the P2X7 purinoreceptor.

The application discloses a preparation method of 3-amino-4-methoxy-N-phenyl benzamide. The method comprises the following steps: taking p-hydroxybenzoic acid as raw material, carrying out amidation reaction, diazotization and reduction reaction to obtain 3-amino-4-hydroxy-N-phenyl benzamide intermediate, and finally carrying out methylation reaction to obtain 3-amino-4-methoxy-N-phenyl benzamide. The solid product of 3-amino-4-methoxy-N-phenyl benzamide obtained by the preparation method has a purity greater than 97%, the overall step operation is simple under the premise of obtaining high yield, three waste emissions are reduced, and the method is more suitable for industrial production.

The application discloses a synthesis method of a 3-position side chain of cefodizime, and relates to the technical field of medicine intermediates. The method comprises the following steps: taking 3-hydroxy-4-methoxybenzaldehyde as a starting material, and preparing a key intermediate 2-chloro-3,4-dipara-methoxybenzyloxy-N-(2-(1-pyrrolidine)ethyl)benzamide through five steps of reactions. First, 2-position chlorine is introduced through low-temperature chlorination, then the side chain is constructed through methylation, Pinnick oxidation to obtain a carboxylic acid, acyl chloride and amidation, demethylation through AlCl3 / pyridine, and finally, the phenolic hydroxyl group is protected through PMB. Through the sequence of chlorination-methylation / oxidation-amidation-demethylation-protection, the method fully utilizes the positioning effect, mild oxidation and selective protection strategy, realizes the advantages of high total yield, high purity, simple operation, cheap raw materials and easy industrial production, provides a high-quality side chain intermediate for subsequent synthesis of cefodizime, and has remarkable economic benefits and practical value.

This invention relates to the field of N-(2,4-dinitrophenyl)-4-nitrobenzamide preparation technology, specifically to a green method for preparing nitramide compounds. The method involves adding a catalyst and dispersant to a reactor and mixing them uniformly. Then, a first and a second stream of materials are simultaneously added dropwise to the reactor for reaction. The temperature within the system is controlled during the dropwise addition. After the dropwise addition is complete, the temperature is increased to continue the reaction. After the reaction is completed, N-(2,4-dinitrophenyl)-4-nitrobenzamide is obtained through post-treatment. The first stream is a dispersion containing 4-nitro-N-phenylbenzamide, and the second stream is a nitrating agent consisting of a uniform mixture of N₂O₅ and nitric acid. This preparation method features high product conversion rate, a mild reaction process, safe and controllable production process, effectively reduces the amount of residual intermediates, and minimizes pollution.

The present disclosure relates to a benzamide compound and the pharmaceutical use thereof. Specifically, the present disclosure relates to a compound as represented by formula (I), a preparation method therefor, a pharmaceutical composition containing the compound, the use thereof as a therapeutic agent, and the use thereof in the preparation of a drug for treating and / or preventing diseases or conditions associated with SARM1.

Provided in the present invention are a benzamide derivative and the use thereof. The described benzamide derivative is shown as formula (I), and can be used as a histone deacetylase inhibitor (HDACi) to treat tumors or hyperproliferative diseases.

This invention provides 3-amino-4-(piperazin-1-yl)benzamide derivatives, pharmaceutical compositions comprising them, methods for their preparation, and applications. These compounds act as PLAGL2 protein inhibitors, playing a significant role in various diseases, including but not limited to pain, inflammation, immune dysfunction, neurological and psychiatric disorders, respiratory diseases, urinary system diseases, reproductive system diseases, embryonic developmental abnormalities, cell metabolic disorders, differentiation problems, and viral infections. PLAGL2 plays a particularly positive role in the occurrence, development, and prognosis of malignant tumors such as liver cancer, lung cancer, and glioma. The compounds of this invention exhibit excellent PLAGL2 inhibitory activity. This invention also provides the compounds comprising the pharmaceutically acceptable salts thereof, pharmaceutically acceptable carriers or excipients, and methods for their preparation.