811 results about "Benzamide" patented technology

Embodiments of the present invention provide methods and intermediates for the large scale preparation of 2, 4, 6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridyl] benzamide hemisuccinate, as well as formulations and product forms prepared by these methods. Embodiments of the present invention further provide for the preparation of lamidetan acetate (2, 4, 6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridyl] benzamide acetate) and / or a pharmaceutical composition thereof, and / or the use of lamidetan acetate and formulations thereof in subcutaneous drug delivery.

The invention discloses an N-cyclobutyl substituted benzamide isoxazoline compound as well as a preparation method and application thereof. The N-cyclobutyl substituted benzamide isoxazoline compound has broad-spectrum and efficient insecticidal activity at a low dosage, and has a remarkable effect on prevention and treatment of diseases and insect pests in agriculture and forestry and pests in the field of sanitation; moreover, the pesticide composition is safer to non-target organisms, can reduce the damage to plants, non-target organisms and human beings due to overhigh pesticide concentration, and is more beneficial to crop protection and environmental safety.

The invention discloses a low-temperature zinc ion battery high-entropy eutectic electrolyte and a preparation method and application thereof, and relates to the field of batteries, the electrolyte comprises a hydrogen bond donor, a hydrogen bond acceptor and a solvent; the hydrogen bond donor is at least one of methyl sulfonamide, thioformamide, butyramide, asparagine, tert-butylamine, dimethyl propane diamine, oxalyl diamine, benzamide, sulfamide and ethyl sulfonamide; the hydrogen bond receptor is at least one of aspartic acid, glutamic acid, methionine, zinc chloride, zinc perchlorate, zinc fluoborate and zinc acetate; the preparation method comprises the following steps: mixing a hydrogen bond donor and a hydrogen bond acceptor, and heating to convert a solid into a liquid phase; and adding a solvent, and uniformly mixing to obtain the product. The invention also provides a zinc ion battery containing the electrolyte. The high-entropy eutectic electrolyte has the beneficial effects that-NH2 and halogen or carboxyl form hydrogen bonds to perform eutectic reaction, the freezing point of the eutectic solution is lower than that of a reactant, and the solvent is added to improve the confusion degree of the electrolyte, so that the high-entropy eutectic electrolyte is prepared.

The present disclosure relates to a fungicidal composition. More particularly, the present disclosure relates to a granular fungicidal composition comprising a copper compound and a benzamide fungicide. The present disclosure also relates to a process for preparing the fungicidal composition and a method for controlling growth of fungal phytopathogens using the same.

The invention discloses a gamma-aminobutyric acid gated chloride ion channel allosteric modifier compound and an application thereof, namely (S)-4-(5-(3-chloro-5-(trifluoromethyl) phenyl)-5-(trifluoromethyl)-4, 5-dihydroisoxazole-3-yl)-2-methyl-N-(2-oxo-2-((2, 2, 2-trifluoroethyl) amino) ethyl) benzamide, and a preparation method of the gamma-aminobutyric acid gated chloride ion channel allosteric modifier compound. The compound has an excellent control effect on pests of thysanoptera, acarina, lepidoptera and the like, is very friendly to bees and high in environmental ecological safety, can be used for preparing efficient, low-toxicity and safe insecticides, and has a wide application prospect in agricultural production.

The invention belongs to the technical field of ETFE film preparation, and particularly relates to a preparation method of a high-strength ETFE film. The preparation method of the ETFE film comprises the following steps: preparing a mixture of modified nano cellulose and calcium magnesium silicate whiskers; carrying out modification treatment on the poly (p-benzamide) fiber; and preparing the ETFE film. According to the preparation method of the high-strength ETFE film, the perfluoroalkoxy copolymer and the ETFE resin are selected and mixed for use, during melt extrusion, the perfluoroalkoxy copolymer can lubricate the ETFE and reduce the overall melt viscosity, the critical shear rate of the perfluoroalkoxy copolymer is higher than that of the ETFE, melt fracture can be inhibited, the film is evenly extruded, the flatness of the film surface is improved, and the high-strength ETFE film is prepared. And meanwhile, the elastic retraction of the ETFE is inhibited during high-temperature setting. And the modified nano cellulose and calcium magnesium silicate whisker mixture and the modified poly-p-benzamide fiber are added to enhance the mechanical strength of the prepared ETFE film.

The invention relates to a preparation method of 2-(2-amino-5-bromo-benzoyl) pyridine, which comprises the following steps: by taking 1, 2-diphenyl-1H-benzimidazole (I) as a starting material, oxidizing under the action of chromium trioxide and acetic acid to obtain N-[2-(2-pyridinecarbonyl) phenyl] benzamide (II), hydrolyzing the N-[2-(2-pyridinecarbonyl) phenyl] benzamide (II) under the action of sulfuric acid to obtain 2-(2-aminobenzoyl) pyridine (III), and reacting the 2-(2-amino-5-bromo-benzoyl) pyridine (III) with the 2-(2-amino-5-bromo-benzoyl) pyridine (III) to obtain the 2-(2-amino-5-bromo-benzoyl) pyridine. And (III) performing substitution reaction with NBS in DCM to obtain the target product 2-(2-amino-5-bromo-benzoyl) pyridine. The method has the advantages of mild reaction conditions, higher product purity, high yield, simplicity and convenience in operation, low cost and easiness in industrialization.

There is provided an alkali metal salt of 4-chloro-N-[2-[(4-chlorophenyl)methyl]-3-oxo-1,2,4-thiadiazol-5-yl]benzamide and formulations thereof. This salt finds particular utility in the treatment or prevention of a disorder or condition ameliorated by the activation of AMPK.

The invention relates to a preparation method of 2-(2-amino-5-bromo-benzoyl) pyridine, which comprises the following steps: (1) dissolving 2-amino-5-bromobenzoic acid in an organic solvent A, adding dimethyl hydroxylamine hydrochloride, a condensing agent and organic alkali, and carrying out condensation reaction to obtain 2-amino-5-bromo-N-methoxy-N-methyl benzamide; and (2) in an organic solvent B, enabling 2-bromopyridine to react with the 2-amino-5-bromo-N-methoxy-N-methyl benzamide in the step (1) under the action of an organic strong base, so as to obtain the 2-(2-amino-5-bromo-benzoyl) pyridine. The preparation method provided by the invention has the advantages of easily available synthesis raw materials, low cost, simple synthesis route, safe and controllable synthesis process and simple post-treatment method, has no amplification effect, and is suitable for industrial large-scale production.

To provide a method for producing 4-ketobenzamide derivatives and 4-ketobenzoic acid derivatives.SOLUTION: The present invention provides a method for producing a 4-ketobenzamide compound represented by formula (2), by amidating a compound represented by formula (1), which is obtained through cyanation of a compound represented by formula (3), as well as a method for producing a 4-ketobenzoic acid derivative represented by formula (6), by hydrolyzing the compound represented by formula (1) or the compound represented by formula (2), and a method for producing a 4-ketobenzoic acid ester derivative represented by formula (5), by esterifying the compound represented by formula (2), wherein R1 represents a C1-C6 alkyl group or the like, R2 represents a C1-C6 alkyl group or the like, R3 represents a C1-C6 alkyl group or the like, X represents a halogen atom or the like, Y represents a C1-C6 alkyl group or the like, and n represents an integer of 0-3.SELECTED DRAWING: None

The invention discloses a bacteriostatic plastic packaging material and a preparation method thereof, and relates to the technical field of packaging materials, the packaging material is prepared from the following components by weight: 90-120 parts of plastic resin, 10-20 parts of maleic anhydride grafted polyethylene, 5-15 parts of poly-p-benzamide fiber, 4-12 parts of modified titanium dioxide, 3-10 parts of polyvinyl alcohol, 1-3 parts of a coupling agent, 1-3 parts of a lubricant, and 1-3 parts of a plasticizer. The prepared packaging material combines the photocatalytic antibacterial property of the modified titanium dioxide, the toughening effect of the poly-p-benzamide fiber and the synergistic effect of all functional aids, and has excellent antibacterial property, mechanical property and processability.

There is provided an alkali metal salt of 4-chloro-N-[2-[(4-chlorophenyl)methyl]-3-oxo-1,2,4-thiadiazol-5-yl]benzamide and formulations thereof. This salt finds particular utility in the treatment or prevention of a disorder or condition ameliorated by the activation of AMPK.

The present invention provides a pharmaceutical composition containing Compound 1, which has excellent disintegrability and bioavailability. The present invention relates to a pharmaceutical composition comprising: a granulated material containing 3-ethyl-4-{4-[4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl]-3-(propan-2-yl)-1H-pyrazolo [3, 4-b] pyridin-1-yl} benzamide or a pharmaceutically acceptable salt thereof, and a crystalline cellulose, the granulated material being characterized in that: the granulated material contains a compound represented by general formula (1); the pharmaceutical composition has a disintegration time within 360 seconds in a coated tablet state.

The invention belongs to the technical field of medicinal chemistry, and particularly relates to a 3-sulfamoyl benzamide compound as well as a preparation method and application thereof. The 3-sulfamoyl benzamide compound has a structure as shown in a formula I. In the formula I, X is chlorine or trifluoromethyl; r1 and R2 are independently C1-4 alkyl or R1, R2 and N atoms connected with R1 and R2 jointly form a heterocyclic group, and the heterocyclic group is a substituted or unsubstituted five-membered or six-membered heterocyclic group; and when the heterocyclic group is a substituted heterocyclic group, the substituent group in the substituted heterocyclic group is one or more of C1-4 alkyl, phenyl and acetyl. The 3-sulfamoyl benzamide compound disclosed by the invention has a remarkable proliferation inhibition effect on HCT116 colon cancer cells, HeLa human cervical cancer cells, MDA-MB-231 human breast cancer cells and A375 human malignant melanoma cells.

The present disclosure relates to a fungicide composition. More specifically, the present disclosure relates to a liquid fungicide composition comprising a combination of a benzamide based fungicide and a surfactant. The present disclosure also relates to a method for preparing the fungicide composition and a method for controlling the growth of a fungal plant pathogen using the fungicide composition.

The invention discloses a compound mosquito larvae killing composition and application thereof. The compound mosquito larvae killing composition comprises 1% to 5% of active ingredients, 0% to 5% of liquid original drug adsorbent, and 2% to 8% of slow-release coating agent (including 1% to 4% of active ingredients A and active ingredients B, wherein the active ingredient A is a piperic acid derivative compound, and the active ingredient B is selected from any one of pyriproxyfen, fenthion, dimethoate, fenoxycarb, S-methoprene, dinotefuran, thiamethoxam, acetamiprid, imidacloprid, nitenpyram, cyantraniliprole, and chlorantraniliprole. The active ingredients A and B are compounded and processed into granules for mosquito larvae control, and the granules have good lethal effect, long lasting effect, slow-release effect, and reduced labor cost; the compound mosquito larvae killing composition can be widely used in sewage ditches, sewers, and other places, and has special effects on mosquito larvae control.

The invention relates to preparation of a crystalline allyl covalent organic framework material and application research of the crystalline allyl covalent organic framework material in benzamide cyclization green photocatalytic conversion. The SF-COF material is prepared by adopting a step-by-step synthesis method. The preparation method comprises the following steps: synthesizing a COF precursor by taking 1, 3-benzenetricarboxaldehyde and p-aminophenylacetonitrile as raw materials, and preparing the allylation covalent organic framework material with the electronic push-pull effect from the COF precursor and 5, 5 ', 5'-(benzene-1, 3, 5-triyl) tri (thiophene-2-formaldehyde) through a solvothermal method. The material is applied to the field of photocatalytic organic conversion, and benzamide cyclization and conversion of derivatives of benzamide are achieved under irradiation of a blue light LED. The prepared SF-COF has the advantages of efficient charge separation and electron conduction performance, good structural stability and chemical stability and the like. And a catalyzed organic reaction substrate has the advantages of wide universality range, good cycle stability and the like, and shows excellent photocatalytic conversion capability.

Provided herein are methods of treating cancer by administering a treatment compound to a subject in need thereof. The present disclosure also relates generally to methods of inhibiting the activity of a pyruvate dehydrogenase kinase (PDK) using the treatment compound to a subject in need thereof. The treatment compound is a compound of formula (I) or a pharmaceutically acceptable salt, solvate, or a prodrug thereof.

The invention provides a cleaning solution for a semiconductor chip after CMP and a preparation method and application thereof. The cleaning solution for the semiconductor chip after CMP comprises the following components in parts by weight: 1-10 parts of an additive; 1-7 parts of a corrosion inhibitor; 1-10 parts of an organic base; 80 to 90 parts of ultrapure water; preferably, the additive is N-(9-((1R, 3R, 4R, 7S)-1-((bis (4-methoxyphenyl) (phenyl) methoxyl) methyl)-7-hydroxy-2, 5-dioxabicyclo [2.2. 1] heptane-3-yl)-9H-purine-6-yl) benzamide. The invention also relates to a preparation method of the pharmaceutical composition. The cleaning solution for the semiconductor chip after CMP is safe, environmentally friendly and efficient, does not corrode the semiconductor chip, can complete cleaning under the pure soaking process condition without cooperation of an ultrasonic process, and has very good application prospects and large-scale industrial popularization potential in the field of semiconductor chip cleaning.

The invention provides an insecticide composition, an insecticide preparation and preparation and application of the insecticide composition and the insecticide preparation, and relates to the technical field of pesticides. The pesticide composition provided by the invention comprises a component A and a component B, the component A is (1S, 2R, 4S)-1, 3, 3-trimethyl bicyclo [2.2. 1] heptane-2-yl-4-(tert-butyl) benzoate, the component B is chlorantraniliprole, tetrachlorantraniliprole or emamectin benzoate, and the mass ratio of the component A to the component B is 1: (0.25-4). The insecticide composition provided by the invention has relatively high toxicity to lepidoptera pests such as cotton bollworms, plutella xylostella and corn borers, has a remarkable synergistic effect, can remarkably reduce the dosage of chlorantraniliprole, tetrachlorantraniliprole and emamectin benzoate, realizes application reduction and synergy of pesticides, and delays the development of pest resistance to drugs; and all the components are low-toxicity and low-residue compounds and are easy to degrade in the environment.

The invention provides a preparation method of a chlorantraniliprole key intermediate 2-amino-5-cyano-N, 3-dimethyl benzamide, which comprises the following steps: taking cheap and easily available o-methylaniline as a raw material, acylating an aniline substrate through Boc anhydride, carrying out ortho-lithiation on n-butyllithium, introducing carbon dioxide gas, and carrying out acid hydrolysis to obtain 2-amino-3-methyl benzoic acid, thereby obtaining the chlorantraniliprole key intermediate 2-amino-5-cyano-N, 3-dimethyl benzamide. The preparation method comprises the following steps: firstly, preparing an isatoic anhydride intermediate, then carrying out triphosgene ring closing to obtain an isatoic anhydride intermediate, carrying out bromine para-position halogenation, carrying out cuprous cyanide high-temperature Rosenmn-von Braun reaction, and finally carrying out methylamine ring opening to obtain the target product 2-amino-5-cyano-N, 3-dimethylbenzamide, and although the route is long, the yield is high, the continuity is good, few industrial three wastes are generated, and the cost is lower, so that the preparation method has great industrial production value.

Described herein is Bumetanide Dibenzylamide, methods for synthesizing Bumetanide Dibenzylamide, pharmaceutical compositions thereof, and methods of dosing Bumetanide Dibenzylamide for treating epilepsy or other indication for which bumetanide is effective.

Provided is a method of treating malignant tumor by an azabicyclic compound, particularly, with eye disorder reduced. The present invention provides a method for treating malignant tumor, comprising administering an effective amount of 3-ethyl-4-[3-(1-methylethyl)-4-[4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl]-1H-pyrazolo[3,4-b]pyridin-1-yl]benzamide (compound 1) or a salt thereof to a patient in need thereof according to a dosing regimen, wherein the dosing regimen comprises administering the compound 1 or the salt thereof at a dose from 40 mg / body / day to 240 mg / body / day in terms of the amount of the compound 1 for consecutive days, and then providing a withdrawal period of at least 2 days.

The invention relates to the technical field of preparation of N-(2, 4-dinitrophenyl)-4-nitrobenzoyl aniline, in particular to a method for preparing a nitro amide compound by adopting a microreactor. The method for preparing the nitro amide compound comprises the following steps: introducing a sulfuric acid solution of 4-nitro-N-phenylbenzamide and a nitric acid aqueous solution into a microreactor, and reacting to obtain N-(2, 4-dinitrophenyl)-4-nitrobenzamide; the microreactor is provided with at least two reaction modules which are connected in series, and a sulfuric acid solution of 4-nitro-N-phenylbenzamide is divided into at least two strands which are respectively fed into a first reaction module of the microreactor and other reaction modules except the first reaction module; and the nitric acid aqueous solution enters the microreactor in a way of at least one stream. According to the method, the microreactor is used as a reaction carrier, the temperature in the reaction process is controllable, the raw material conversion rate is increased, and the residual amount of an intermediate N-4-nitro-(4-nitrophenyl) benzamide is reduced.

Provided herein are compounds, preferably compounds inhibiting tyrosine kinase enzymatic activity of a protein selected from Abelson protein (ABL1), Abelson-related protein (ABL2), or a chimeric protein BCR-ABL1, compositions thereof, and methods of their preparation, and methods of inhibiting tyrosine kinase enzymatic activity of a protein selected from Abelson protein (ABL1), Abelson-related protein (ABL2), or a chimeric protein BCR-ABL1, and methods for treating diseases wherein modulation of BCR-ABL1 activity prevents, inhibits, or ameliorates the pathology and / or symptomology of the disease. Intermediates such as compounds of Formula (S23), which are useful in the synthesis of compounds inhibiting tyrosine kinase enzymatic activity of a protein selected from Abelson protein (ABL1), Abelson-related protein (ABL2), or a chimeric protein BCR-ABL1, are also provided.

The invention relates to the technical field of benzamide, in particular to a preparation process of 4-hydroxythiobenzamide, which comprises the following steps: S1, preparing raw materials: preparing the 4-hydroxythiobenzamide from the following raw materials in parts by weight: 80-100 parts of formic acid, 80-100 parts of hydrochloric acid, 20-30 parts of 4-hydroxybenzaldehyde, 8-12 parts of hydroxylamine hydrochloride, 8-12 parts of thioacetamide and 4-6 parts of sodium hydroxide. According to the preparation method, after 4-hydroxybenzaldehyde is subjected to activating treatment reaction, part of positive charges on aldehyde carbon are dispersed, oxygen atoms in an acetal structure are connected with the aldehyde carbon through covalent bonds to generate an electron withdrawing induction effect, the reaction sequence and the reaction path of the 4-hydroxybenzaldehyde can be controlled through aldehyde activation, and the reaction efficiency of the 4-hydroxybenzaldehyde is improved. Therefore, the generation of byproducts is reduced, and the purity of a reaction product obtained from 4-hydroxybenzaldehyde is improved.

The invention provides a 3-amino-2-fluorobenzamide compound and a preparation method thereof, and the preparation method comprises the following steps: (1) carrying out a substitution reaction on 5-chloro-2-hydroxy-3-nitrobenzoic acid to obtain 5-chloro-2-fluoro-3-nitrobenzoyl halide with a structure as shown in a formula I; (2) carrying out an amidation reaction on the 5-chloro-2-fluoro-3-nitrobenzoyl halide and an aniline compound with a structure as shown in a formula II to obtain a 3-nitro-2-fluorobenzamide compound with a structure as shown in a formula III; and (3) carrying out a reduction reaction on the 3-nitro-2-fluorobenzamide compound, so as to obtain the 3-amino-2-fluorobenzamide compound with a structure as shown in a formula IV. The preparation method is low in raw material price, almost quantitative in multi-step reaction, few in by-products, high in target product yield and mild in process condition, avoids severe reaction conditions such as deep cooling and high temperature, and is more suitable for industrial production.

The invention relates to an effective amount of novel benzamide derivative as shown in a general formula (I), a preparation method thereof and application of a pharmaceutical composition containing the derivative as a medicine, compared with the prior art, the compound has better metabolic stability, can be orally taken and has a wider application prospect. # imgabs0 #

The present invention provides an isoxazoline-substituted benzamide compound and a stereoisomer and agriculturally or veterinarily acceptable salt thereof. The compound is as represented by formula (I). In the formula, X represents hydrogen, halogen, hydroxyl, alkoxy, or alkylthio; Y is hydrogen, halogen, alkyl, or haloalkyl; Z is haloalkyl or haloalkoxy; M is CH or N; Q is hydrogen or halogen; R1 is hydrogen, halogen, hydroxyl, cyano, amino, nitro, formyl, cyanoalkyl, hydroxyalkyl, alkyl, etc.; and R2 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, etc. The compound has an excellent control effect on pests such as Spodoptera frugiperda, Myzus persicae, Nilaparvata lugens, Tetranychus truncates, and Bradysia odoriphaga.

The present invention includes compositions and methods of for treating plants infected with fungal pathogens by contacting an infected plant or plant at risk of infection with a fungicidal composition comprising an fungicide selected from copper compound such as copper octanoate or copper hydroxide, or a triazole fungicide such as myclobutanil, propionazole, tebuconazole or epoxiconazole, an enhancer selected from apyrase inhibitors, e.g., N-(m-tolyl)-[1,1′-biphenyl]-4-sulfonamide, S-heptyl 2-oxo-2H-chromene 3-carbothioate, 3-(N-(4-bromophenyl) sulfamoyl)-N-(3-nitrophenyl)benzamide, or (E)-3-methyl-N-(1-(naphthalen-2-yl) ethylidene)benzohydrazide and, optionally, a phytologically-acceptable inert carrier.