44 results about "Sulpiride" patented technology

The present invention relates in general to methods of treating sweating disorders and in particular to topical compositions for the treatment of hyperhidrosis. The methods of the present invention relate to the topical application of a composition comprising a therapeutically effective amount of oxybutynin, tolterodine or a substituted benzamide such as sulpiride.

The present invention provides, inter alia, compositions containing enantiomerically pure (R)(+)-amisulpride or enantiomerically pure (R)(+)-sulpiride, optionally with dopamine receptor modulators. The present invention also provides compositions containing racemic (RS)-amisulpride or (RS)-sulpiride in combination with dopamine receptor modulators. Methods for preventing, treating, or ameliorating the effects of a metabolic disorder or key element thereof, for modulating blood glucose levels, and for preventing, treating, or ameliorating the effects of diabetes in a subject are also provided. Additionally, the present invention provides methods for counter-acting the dopamine antagonist activity of (S)-amisulpride in racemic (RS)-amisulpride, or the dopamine antagonist activity of (S)-sulpiride in racemic (RS)-sulpiride, administered to a subject to prevent, treat, or ameliorate the effects of a metabolic disorder.

The invention discloses a method for synchronously detecting seventeen antipsychotics in a blood sample. The method comprises the steps that the sample is extracted with a mixed solution of methanol and acetonitrile to obtain supernate, and after a solvent is removed from the supernate, the supernate is dissolved in a methanol aqueous solution and filtered to obtain a specimen; a high performanceliquid chromatography tandem mass spectrometry method is adopted to detect the specimen; the sample is serum or plasma, and the antipsychotics are amisulpride, aripiprazole, dehydro aripiprazole, chlorpromazine, clozapine, desmethylclozapine, fluphenazine, haloperidol, olanzapine, paliperidone, perphenazine, quetiapine, risperidone, 9-hydroxyrisperidone, sulpiride, ziprasidone and thioridazine; inthe high performance liquid chromatography, a mobile phase A is an aqueous solution of formic acid, and a mobile phase B is a methanol solution of the formic acid; and the mass spectrometry adopts amulti-ion reaction monitoring mode of positive ion electrospray ionization.

The invention discloses a supplemental detection method of seven chemical medicines including carbamazepine, chlorpromazine hydrochloride, olanzapine, doxepin hydrochloride, quetiapine fumarate, oxcarbazepine and sulpiride which are illegally added into health-care food or Chinese patent medicine for improving sleep. After a sample is subjected to ultrasonic extraction with methyl alcohol, chromatogram column separation is conducted, a mobile phase is eluted, and DAN detector is used for detection. By means of a built detection method, methodological verification is conducted, and parameters of results are shown in the description. It is verified that the method is quick, high in specificity and suitable for detection of chemical medicine added to the health-care food or Chinese patent medicine for improving sleep.

The invention discloses a synthesis method of a sulfonamide compound represented in a formula (2). According to the method, diazonium salt is used as a reaction raw material, and under the action of an inorganic nitrogen reagent, an inorganic sulfur dioxide reagent, an additive and a phosphine reagent, the diazonium salt is reacted in a solvent at 60-100 DEG C to obtain various sulfonamide compounds. According to the method inorganic salt is used as a nitrogen atom source and a sulfur dioxide source under a metal-free catalytic condition to construct the sulfonamide compound through one step,thereby avoiding the conventional multi-step synthesis of sulfonamide by condensing unstable acid chloride and amine; and the developed sulfonamide synthesis method can be further applied to the synthesis of the arthritis drug celecoxib and the psychotropic drug sulpiride.

The present invention relates to pharmaceutical compositions containing sulpiride compounds having the general formula:where R1 is branched or straight chain alkyl having from 1 to about 7 carbon atoms, a substituted or unsubstituted aryl, a substituted or unsubstituted cycloalkyl, a substituted or unsubstituted aralkyl, a substituted or unsubstituted alkylcycloalkyl, or a group having the formula (CH2)n R2 where R2 is a substituted or unsubstituted aryl or a substituted or unsubstituted cycloalkyl, and n is an alkyl group having from 0 to about 6 carbon atoms and pharmaceutically acceptable salts or diluents.

The invention relates to a synthesis method for 2-methoxyl-4-amino-5-ethylsulfonylbenzoic acid which is an important immediate for antipsychotics Amisulpride. The method uses 2-methoxyl-4-methyl anthranilate as raw material, and carries out amino protection, sulphurization, deamination protection, chloridization, reduction, thylization, esterolysis and crystallization, and then the 2-methoxyl-4-amine-5-ethylsulfonylbenzoic acid is prepared. The method uses common reagents with easy obtainment as reaction mediums, the reaction condition is high, and the prepared product has the advantages of high purity and high yield, and is suitable for industrialization production.

The present invention relates to a tricyclic compound or its stereo-isomer or its pharmaceutically-acceptable salt and their application in preparation of medicine for curing the disease of central nervous system. Besides, said invention also provides the chemical general formula of said tricyclic compound and its detailed description.

The medicine for treating depression and other mental disturb diseases is prepared with chlorimipramine, sulpiride, sodium valproate, borneol and Chinese herbal medicine extractum prepared with nutagrass flatsedge rhizome, arisaema with bile, wild jujube seed and other Chinese medicinal materials. The medicine consists of chemically synthetic medicine and Chinese herbal medicine component, and has synergistic treating effect, less toxic side effect, and good patient's compliance.

The invention belongs to the technical field of drug detection, and particularly relates to a method and a kit for detecting 19 drugs and metabolites thereof in blood through liquid chromatography-tandem mass spectrometry. The substances to be detected comprise sulpiride, pentafluridol, mianserin, buspirone, tandospirone, hydroxyazine, diazepam, venlafaxine, moclobemide, imipramine, paroxetine, reboxetine, amitriptyline, sertraline, digoxin, clonazepam, clopidogrel, toluenesulfobutyl urea, glimepiride, 1-pyrimidinepiperazine, desmethylvenlafaxine, 6-hydroxy buspirone and normipramine, and the substances to be detected are selected from the group consisting of sulpiride, pentafluridol, mianserin, venlafaxine, metandospirone, metandospirone, hydroxazine, diazepam, venlafaxine, moclobemide, the pharmaceutical composition is prepared from noramitriptyline, nordiazepam and clopidogrel metabolite; the detection method comprises the following steps: calibrating a standard solution, treating a to-be-detected sample, and detecting the to-be-detected sample by adopting high performance liquid chromatography-mass spectrometry. The embodiment of the invention can quickly and accurately measure the content, and the sample treatment method is simple and easy to implement, high in sensitivity and accurate in quantification.

The invention belongs to the technical field of pharmaceutical preparation and particularly relates to a sulpiride tablet and a preparation method thereof. The preparation method comprises the following steps: weighing 300g of PEG 4000 and 20-30g of PVPk30, dissolving 95% ethanol to obtain an additive solution; dissolving 1000g of sulpiride in 95% ethanol to obtain a main medicine solution; uniformly mixing the additive solution with the main medicine solution to obtain a mixed solution; carrying out vacuum drying on the mixed solution; crushing the obtained solid material, shearing 300g of microcrystalline cellulose and 200g of lactose in a granulator for granulation, and drying the granules in a boiling dryer; trimming the dry granules in a 20-30-mesh sieve, mixing the obtained granules with a lubricating agent in the prescription and tabletting.

The invention relates to a detection method of sulpiride tablets. The method comprises the steps as follows: step 1, preparation of a reference substance liquid: 25 mg of a sulpiride reference substance is taken, diluted acetic acid is added to help disliquid, the liquid is diluted with water serving as a solvent to be 0.5 mg / ml, and the obtained liquid is diluted to be 50 mu g / ml; step 2, preparation of a test liquid: 20 sulpiride tablets are ground to be fine and uniformly mixed, a proper amount of powder is taken, diluted acetic acid is added to help disliquid, the liquid is diluted with water serving as a solvent to be 0.5 mg / ml, and the obtained liquid is diluted to be 50 mu g / ml; step 3, the standard reference substance liquid and the sample liquid are injected into a high performance liquid chromatograph, a chromatogram is obtained, and the content of sulpiride in the sample is calculated according to the chromatogram.

A dispersive tablet of surpiride for treating psychosis is prepared proportionally from surpiride, carboxymethyl starch sodium, microcrystalline cellulose and dextrin through mixing, adding the alcohol solution of polyvinyl pyrrolidone, mixing, wet granulating, drying, adding carboxymethyl starch, talc powder, SDS and magnesium stearate, stirring and tablet pressing.

The invention relates to a preparation method for high-purity sulpiride or optical isomers thereof. The method comprises the following steps: first, crude products of sulpiride or optical isomers thereof are added in ethanol aqueous solutions with different concentrations of 10-90%, under a normal condition or under protection of inert gases (nitrogen usually), the solutions are heated and the crude products are dissolved, when the solutions are cooled slightly, active carbon is added for decolouring or is not added; second, filtration is carried out, the filtrate is cooled, crystals are precipitated, filtration, washing and drying are carried out. The charging ratio is small, ethanol dosage is decreased obviously, the refining efficiency is raised greatly, the production cost is lowered, the yield is raised, the impurity amount is decreased obviously and the product quality is raised greatly.

The invention discloses a preparation method of environment-friendly and high-purity sulpiride. The preparation method comprises the following steps of preparation of a crude product; activation of bamboo charcoal, wherein, in the activation process of the bamboo charcoal, fermenting bamboo powder by adopting EM (Effective Microorganism) bacterial liquid, drying, crushing, immerging in a sodium hydroxide solution, standing, filtering, drying, sending into a vacuum box, activating at a high temperature, washing until being neutral, drying and crushing, so that activated bamboo charcoal is obtained; purification of the coarse product: in the purification process of the crude product, adding absolute ethyl alcohol into the crude product, refluxing at a temperature of 80 to 100 DEG C, coolingthe temperature to 0 to 2 DEG C, filtering, adding an ethyl alcohol solution with a concentration of 80wt% to 95wt%, refluxing at the temperature of 80 to 100 DEG C, adding the activated bamboo charcoal, continuously refluxing, ultrasonically treating, filtering, crystallizing, and carrying out vacuum drying, so that the environment-friendly and high-purity sulpiride is obtained. A product obtained by the preparation method is high in purity and yield; the preparation technique is simple; the use level of an organic matter in a preparation process is low; in addition, the ethyl alcohol in a rejected material is easily recovered and can be further repeatedly utilized; the waste to a resource and the pollution to an environment can be reduced, and the preparation method is safe and environment-friendly.

The invention relates to a sulpiride tablet, and a preparation method thereof. The sulpiride tablet comprises, by weight, 50 to 200 parts of sulpiride, 1.2 to 2.4 parts of a disintegrating agent, 15 to 40 parts of an filler, 0.3 to 1 part of an adhesive, and 0.1 to 1 part of a lubricant. The preparation method comprises following steps: sulpiride is subjected to micronization until obtained powderis capable of passing through a mesh of 100 meshes so as to obtain sulpiride fine powder; the sulpiride fine powder is uniformly mixed with the filler; the prepared adhesive is added so as to obtaina soft material; and then pelletizing, drying, size stabilization, lubricant adding and total mixing, performing, and packaging are carried out so as to obtain a finished product.

The present invention relates to pharmaceutical compositions containing sulpiride compounds having the general formula: where R1 is branched or straight chain alkyl having from 1 to about 7 carbon atoms, a substituted or unsubstituted aryl, a substituted or unsubstituted cycloalkyl, a substituted or unsubstituted aralkyl, a substituted or unsubstituted alkylcycloalkyl, or a group having the formula (CH2)n R2 where R2 is a substituted or unsubstituted aryl or a substituted or unsubstituted cycloalkyl, and n is an alkyl group having from 0 to about 6 carbon atoms and pharmaceutically acceptable salts or diluents.

The invention discloses an electrochemical detection method for sulpiride. The method comprises the steps of preparing alpha-MoO3 powder by a hydro-thermal synthesis method, and depositing alpha-MoO3in the form of nanometer rods on the surface of a pretreated glassy carbon electrode by using a thermal evaporation method; preparing the sulpiride into standard solution with different concentrationsby using Tris-HCl, adjusting the pH value of the solution, soaking the glassy carbon electrode modified by the alpha-MoO3 nanometer rods into the solution to perform differential pulse volt-ampere detection, preparing a peak current-concentration standard curve, and displaying a good linear relation; and placing the modified electrode into the solution to be detected for detecting, and working out the concentration of the sulpiride in the solution to be detected according to the standard curve. The method can quickly measure the concentration of the sulpiride, the measurement limit reaches 1.0*10<-8>mol / L, the linear range is 5.0*10<-8>-1.0*10<-5>, and the sensitivity is high.

The present invention discloses one kind of medicine composition for treating depression and relevant diseases, and the medicine composition includes certain amount of venlafaxine or its medicinal salt or solvate, certain amount of sulpiride or its solvate, and one or several kinds of medicine carrier or excipient. The medicine composition has such amount of sulpiride and venlafaxine as to result in synergistic effect. The medicine composition is used in treating depression and relevant diseases, and has less untoward reaction.

The invention belongs to the technical field of pharmaceutical preparation and particularly relates to a sulpiride tablet and a preparation method thereof. The preparation method comprises the following steps: weighing 300g of PEG 4000 and 20-30g of PVPk30, dissolving 95% ethanol to obtain an additive solution; dissolving 1000g of sulpiride in 95% ethanol to obtain a main medicine solution; uniformly mixing the additive solution with the main medicine solution to obtain a mixed solution; carrying out vacuum drying on the mixed solution; crushing the obtained solid material, shearing 300g of microcrystalline cellulose and 200g of lactose in a granulator for granulation, and drying the granules in a boiling dryer; trimming the dry granules in a 20-30-mesh sieve, mixing the obtained granules with a lubricating agent in the prescription and tabletting.

The invention discloses a levosulpiride compound and a preparation method of the levosulpiride compound. The method is characterized in that methyl alcohol and N,N-dimethylformamide in prescribed proportion are adopted as solvents, sulpiride is resolved under the ultrasound condition to achieve turnover of dextroisomer, low temperature vacuum ultrasound is adopted for crystallization, and novel levosulpiride dehydrate and the preparation method of the levosulpiride dehydrate are obtained. The levosulpiride compound and the preparation method are moderate in resolution condition and easy to industrialize, improves the product yield and purity, shortens the resolution time and reduces cost, product stability is good, the validity period is prolonged, and a satisfied effect is obtained.

The present invention relates in general to methods of treating sweating disorders and in particular to topical compositions for the treatment of hyperhidrosis. The methods of the present invention relate to the topical application of a composition comprising a therapeutically effective amount of oxybutynin, tolterodine or a substituted benzamide such as sulpiride.

The invention belongs to the technical field of drug detection, and particularly relates to a method and a kit for detecting 19 kinds of drugs and their metabolites in blood by liquid chromatography tandem mass spectrometry. Substances to be tested include sulpiride, penfluridol, mianserin, buspirone, tandospirone, hydroxyzine, diazepam, venlafaxine, moclobemide, imipramine, paroxetine, rebo Cetine, amitriptyline, sertraline, digoxin, clonazepam, clopidogrel, tolbutamide, glimepiride, 1-pyrimidine piperazine, desvenlafaxine, 6- Hydroxybuspirone, norimipramine, noramitriptyline, nordiazepam, clopidogrel metabolites; detection methods include: calibrating standard solutions, processing samples to be tested, using high performance liquid chromatography‑ Mass spectrometry detects the sample to be tested. The embodiment of the present invention can quickly and accurately measure the content, the sample processing method is simple and easy, and has high sensitivity and accurate quantification.

The invention belongs to the technical field of medicines, and especially relates to a preparation method of an impurity compound in a key intermediate for synthesizing sulpiride and an application thereof. The impurity compound can be obtained through a condensation reaction by placing a compound II and a compound III in a solvent, or the impurity compound can be obtained by refining a compound IV and taking a filtrate, or the impurity compound can be obtained by separating and purifying from the compound IV. The standard substance of the impurity compound prepared by the preparation method can be used for analysis and detection of impurities in the key intermediate drug of sulpiride, and the technical problem that impurity compounds and other acceptable salt standard substances used as analysis and comparison compounds do not exist so far is solved, thereby medication safety of sulpiride is improved and guaranteed.

The invention relates to a preparation method of levosulpiride injection. The method is characterized in that levosulpiride is dissolved in water for injection containing equimolar pharmaceutically acceptable acid, and the pH of the injection is adjusted to 4-6. The method of the invention can be used to prepare side effects Water injection and freeze-dried powder injection with low dosage and good stability.

The invention relates to a preparation method for high-purity sulpiride or optical isomers thereof. The method comprises the following steps: first, crude products of sulpiride or optical isomers thereof are added in ethanol aqueous solutions with different concentrations of 10-90%, under a normal condition or under protection of inert gases (nitrogen usually), the solutions are heated and the crude products are dissolved, when the solutions are cooled slightly, active carbon is added for decolouring or is not added; second, filtration is carried out, the filtrate is cooled, crystals are precipitated, filtration, washing and drying are carried out. The charging ratio is small, ethanol dosage is decreased obviously, the refining efficiency is raised greatly, the production cost is lowered, the yield is raised, the impurity amount is decreased obviously and the product quality is raised greatly.

The invention belongs to the technical field of medicines, and especially relates to a preparation method of an impurity compound in a key intermediate for synthesizing sulpiride and an application thereof. The impurity compound can be obtained through a condensation reaction by placing a compound II and a compound III in a solvent, or the impurity compound can be obtained by refining a compound IV and taking a filtrate, or the impurity compound can be obtained by separating and purifying from the compound IV. The standard substance of the impurity compound prepared by the preparation method can be used for analysis and detection of impurities in the key intermediate drug of sulpiride, and the technical problem that impurity compounds and other acceptable salt standard substances used as analysis and comparison compounds do not exist so far is solved, thereby medication safety of sulpiride is improved and guaranteed.