Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Detection method of sulpiride tablets

A detection method and sulpiride technology, applied in the detection field of sulpiride tablets, can solve the problems of low sensitivity, deviation of chromatographic conditions, large errors, etc., and achieve the effect of high precision and accurate liquid phase detection method

Inactive Publication Date: 2018-05-18
南京双科医药开发有限公司
View PDF3 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The method is simple and convenient to operate, low in technical requirements, but poor in precision and low in sensitivity
[0005] With the deepening of drug research, it is necessary to carry out more accurate identification and control of content of sulpiride tablets, for which HPLC method is needed to detect it, but the existing HPLC method detects sulpiride tablets of the present invention, and the error is relatively large, the reason Because the sulpiride tablet of the present invention contains croscarmellose sodium, which leads to deviations in chromatographic conditions

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Detection method of sulpiride tablets
  • Detection method of sulpiride tablets
  • Detection method of sulpiride tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Step 1, preparation of reference substance solution: take about 25 mg of sulpiride reference substance, accurately weigh it, add dilute acetic acid to aid dissolution, dilute with water to 0.5 mg / ml, and use it as a liquid phase detection sample; then dilute to make 50 μg / ml ;

[0070] Step 2, preparation of the test solution: take 20 tablets of sulpiride, grind and mix them evenly, take an appropriate amount of powder (equivalent to about 25 mg of sulpiride), weigh it accurately, add dilute acetic acid to help dissolve, dilute with water to reach 0.5 mg / ml, as a liquid phase detection sample; then diluted to make 50μg / ml;

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a detection method of sulpiride tablets. The method comprises the steps as follows: step 1, preparation of a reference substance liquid: 25 mg of a sulpiride reference substance is taken, diluted acetic acid is added to help disliquid, the liquid is diluted with water serving as a solvent to be 0.5 mg / ml, and the obtained liquid is diluted to be 50 mu g / ml; step 2, preparation of a test liquid: 20 sulpiride tablets are ground to be fine and uniformly mixed, a proper amount of powder is taken, diluted acetic acid is added to help disliquid, the liquid is diluted with water serving as a solvent to be 0.5 mg / ml, and the obtained liquid is diluted to be 50 mu g / ml; step 3, the standard reference substance liquid and the sample liquid are injected into a high performance liquid chromatograph, a chromatogram is obtained, and the content of sulpiride in the sample is calculated according to the chromatogram.

Description

technical field [0001] The invention relates to a drug detection method, in particular to a detection method for sulpiride tablets Background technique [0002] Sulpiride, a benzamide compound, is an atypical antipsychotic. In the hypothalamus, pons and medulla oblongata, it can antagonize D1 and D2 receptors, and also has certain antagonistic effects on D3 and D4 receptors. It has an emotional activation effect. It has strong anti-stuppity, withdrawal, hallucinations, delusions and insanity, and has a certain anti-depressant effect. Has a strong central antiemetic effect. Anticholinergic effect is weak, no sedative hypnotic effect and anti-excitement restlessness effect. This product is absorbed from the gastrointestinal tract, and the peak plasma concentration can be reached within 2 hours. After taking this product orally for 48 hours, 30% of the oral dose will be excreted in urine and part of it will be excreted in feces. Plasma half-life is Hours, mainly excrete...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): G01N30/06G01N30/74
CPCG01N30/06G01N30/74
Inventor 薛胜爽
Owner 南京双科医药开发有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com