49 results about "Atypical antipsychotic" patented technology

This invention relates to combinations of an atypical antipsychotic, and a nicotinic receptor agonist or antagonist, kits containing such combinations, pharmaceutical compositions comprising such combinations, and methods of using such combinations to treat patients suffering from cognitive impairment disorders or psychotic disorders or conditions.

This invention relates to combinations of an atypical antipsychotic, and a GABA modulator, a benzodiazepine, and/or an anticonvulsant drug, kits containing such combinations, pharmaceutical compositions comprising such combinations, and methods of using such combinations to treat patients suffering from treatment-resistant anxiety disorders, psychotic disorders or conditions, or mood disorders or conditions.

This invention relates to combinations of an atypical antipsychotic, for example ziprasidone, and a dopamine agonist, kits containing such combinations, pharmaceutical compositions comprising such combinations, and methods of using such combinations to treat patients suffering from psychosis and movement disorders associated with Parkinson's disease and subcortical dementias.

The present invention relates to a pharmaceutical composition for treating, for example, a disorder or condition selected from the group consisting of hypertension, depression, generalized anxiety disorder, phobias, posttraumatic stress disorder, avoidant personality disorder, sexual dysfunction, eating disorders, obesity, chemical dependencies, cluster headache, migraine, pain, Alzheimer's disease, obsessive-compulsive disorder, panic disorder, memory disorders, Parkinson's diseases, endocrine disorders, cerebellar ataxia, gastrointestinal tract disorders, negative symptoms of schizophrenia, premenstrual syndrome, Fibromyalgia Syndrome, stress incontinence, Tourette syndrome, trichotillomania, kleptomania, male impotence, cancer, chronic paroxysmal hemicrania and headache in a mammal, preferably a human, comprising (i) an atypical antipsychotic or a pharmaceutically acceptable salt thereof,

• • (ii) a 5-HT_1B receptor antagonist or a pharmaceutically acceptable salt thereof, wherein the 5-HT_1B receptor antagonist is selected from the group consisting of (A) a compound of the formula I as described in the specification and (B) a compound of the formula II as described in the specification, and optionally (iii) a pharmaceutically acceptable carrier.

The present invention relates to a pharmaceutical combination of a glycine transporter inhibitor (GlyT1) and an atypical antipsychotic drug which may be used for the treatment of positive and negative symptoms of schizophrenia.

The invention relates to a method for preparing lurasidone and preparation of atypical antipsychotic compound lurasidone, and in particular relates to a method for preparing single salt silicate. The method comprises the following steps of: halogenating hydroxy by using a compound I as an initial raw material to prepare an intermediate compound II; reacting the intermediate compound II with a compound V under an alkalinity condition to generate an intermediate compound VI; and reacting the intermediate compound VI with a compound III under the alkalinity condition to prepare a target product of lurasidone. The method is short in process routine, easy to control and convenient to operate; and the generation of impurities is avoided, the reaction yield is obviously improved, the raw materials are cheap and easy to acquire, and the large-scale production is facilitated.

A pharmaceutical composition that contains an atypical antipsychotic drug and succinic acid, fumaric acid or a mixture of succinic acid and fumaric acid.

Pharmaceutical compositions comprising an atypical antipsychotic as an active agent, process of preparation thereof and method of using the same are provided. Particularly the present invention relates to pharmaceutical compositions comprising lurasidone, process of preparation thereof and method to treat various psychotic disorders such as schizophrenia, positive and negative symptoms of schizophrenia, memory or learning dysfunctions caused by schizophrenia, senile dementia, attention deficit/hyperactivity disorder (ADHD), central nervous system (CNS) disorder responsive to modulation of glutamate levels, major depressive episodes associated with bipolar I disorder and other associated CNS disorders.

A method for identifying typical and atypical antipsychotics based on their ability to reduce neuronal/glial activity in specific brain regions upon dopaminergic neurotransmission is disclosed.

This invention encompasses compounds of the formula: where either R1 or R2 represents and the other represents hydrogen or straight or branched chain lower alkyl having 1-6 carbon atoms; and X is oxygen, methylene, or NH; Y is represents various inorganic and organic substituents; Z is hydrogen, amino or NHR6 where R6 is lowere alkyl having 1-6 carbon atoms; T is hydrogen, halogen, hydroxy, or lower alkoxy having 1-6 carbon atoms; and A is methylene, carbonyl or CHOH. These compounds are selective partial agonists or antagonists at brain monoamine receptor subtypes or prodrugs thereof and are useful in the diagnosis and treatment of affective disorders such as schizophrenia and depression as well as certain movement disorders such as Parkinsonism. Furthermore compounds of this invention may be useful in treating the extrapyramidal side effects associated with the use of conventional neurolepticagents. These compounds show unexpectedly atypical antipsychotic profiles (clozapine-like) in the animal models described in this patent.

The present invention provides novel compounds of Formula I:

The invention further relates to pharmaceutical compositions comprising compounds of Formula I and to methods of using compounds of Formula I to treat neuropsychiatric disorders (e.g., psychosis, depression, schizophrenia).

The invention provides Asenapine tablets and a preparation method thereof. The tablets comprise the following components in percentages by weight: 10-50% of Asenapine, 30-80% of a filler, 3-20% of a disintegrating agent, 0.5-1% of lubricant, and 0.2-2.5% of a flavouring. The preparation method comprises the following steps: micronization is carried out for Asenapine and the filler, and the particle size is controlled at 0.5-20[mu]m; the fine powder obtained in the last step and partial disintegrating agent are prepared into a soft material with an ethanol water, and granulation is carried out with 24 mesh sieve; prepared fine granules are dried at 50-70 DEG C, and granulation is carried out with 20 mesh sieve; the residual disintegrating agent, the flavouring and the lubricant are added into dried particles in order, total mixing is carried out twice, one mixing is carried out before the lubricant is added, the other mixing is carried out after the lubricant is added, till intermediate detection is qualified, the tablets are compressed, and the product is prepared. Asenapine tablets are common tablets with coating or without coating, the product is a novel atypical antipsychotic drug; the drug has the advantages of fast drug absorption, high bioavailability, and usage convenience.

The invention provides a composite probiotic dietary fiber composition, which is used for relieving weight gain caused by atypical antipsychotic drugs, the composition is composed of dietary fibers and probiotics, the mass ratio of the probiotics to the dietary fibers is 1: (30-40), the dietary fibers comprise soluble dietary fibers and insoluble dietary fibers, the mass ratio of the soluble dietary fibers to the insoluble dietary fibers is (8-10): 1; the viable count of the probiotics is not less than 5.0*10 <7> CFU/g. By using the composite probiotic dietary fiber composition, weight gain caused by atypical antipsychotics can be effectively relieved.

The present invention is directed to therapeutic agents of the formula (I) which are atypical antipsychotics and which are useful in the treatment of neurological and psychiatric disorders associated with dopamine D2 and serotonin 5-HT2A neurotransmission dysfunction. wherein; R¹ is C₁-6alkyl, which is unsubstituted or substituted with 1-6 fluoro, wherein R¹ and the hydroxyl group on the ring are attached to the same carbon atom; or a pharmaceutically acceptable salt thereof.

Methods and compositions for preventing or reducing weight gain and associated metabolic syndrome in patients receiving atypical antipsychotic drugs for treatment of mental illnesses are described. The invention comprises administering to a patient in need of treatment an effective amount of a dopamine agonist in conjunction with an effective amount of an atypical antipsyochotic drug. In one embodiment of the invention, the dopamine agonist is pramipexole. The dopamine agonist may be administered in a low dose, such as less than 1 mg per day of pramipexole. Examples of atypical antipsychotic drugs which may be administered in conjunction with the dopamine agonist include clozapine, olanzapine, quetiapine and risperadone.

Polycondensated heterocycles with a pyrrole[2,1-b][1,3]benzothiazepine structure of the following formula (I) where the groups are defined as in the description are disclosed. As compared to known antipsychotic agents, these compounds present substantial activity associated with a simultaneous reduction in unwanted extrapyramidal symptoms. These compounds can be formulated in pharmaceutical compositions for the treatment of psychoses such as, for example, schizophrenia.