199 results about "Monoamine oxidase" patented technology

The invention belongs to the field of medicine, and in particular relates to a medical application of 2-([1,1'-biphenyl]-4-yl)-2-oxoethyl 4-((3-chloro-4-methylphenyl) amino)-4-oxobutanoate in a selective histone lysine-specific demethylase 1 (LSD1) inhibitor, especially the application in anti-tumor medicaments. Pharmacodynamic tests indicate that the 2-([1,1'-biphenyl]-4-yl)-2-oxoethyl 4-((3-chloro-4-methylphenyl) amino)-4-oxobutanoate has a remarkable LSD1 inhibiting effect, and has selectivity to homologous proteins MAO-A (monoamine oxidase-A) and MAO-B.

The invention discloses pleurotus citrinopileatus sing ultrafine power cultured by using ramulus mori stems as major ingredients and a production method of the pleurotus citrinopileatus sing ultrafine power. The production method is characterized in that the ramulus mori stems is adopted as the major ingredients of the pleurotus citrinopileatus sing ultrafine power, 35-55 DEG C low-temperature vacuum drying is carried out for 4 to 5 hours, the crushing is carried out by a 500-1000-mesh sieve ultrafine crushing machine, and the pleurotus citrinopileatus sing ultrafine dry power is obtained. The pleurotus citrinopileatus sing ultrafine power and the production method have the advantages that the original nutrition and health care characteristics of pleurotus citrinopileatus sing can be maintained, the activity of B type monoamine oxidase is inhibited, in addition, the peroxyl lipid content of the liver can be reduced, the lipofuscin content of the heart is reduced, the activity of SOD (super oxygen dehydrogenises) in red blood cells can be improved, good effects of nourishing yin and yang, delaying senescence, preventing and resisting cancer, lowering the blood pressure and the like are realized, in addition, more convenient edible performance and efficient utilization performance of the health care ingredients are realized, and meanwhile, the silkworm industrial chain can be favorably prolonged.

The present invention provides a method for producing an alkaloid, for example, reticuline, comprising providing dopamine as a substrate for a series of actions of monoamine oxidase, norcoclaurine-6-O-methyltransferase, coclaurine-N-methyltransferase and 3′-hydroxy-N-methylcoclaurine-4′-O-methyltransferase.

The invention relates to an olefinic polymerization non-metallocene metal catalyst system and preparation and application thereof. A main catalyst is shown as a structural formula (1), wherein M represents Ti, Zr, Hf, Sc, Y, La, Nd or Sm; methylaluminoxane or modified methylaluminoxane is taken as a cocatalyst; and the molar ratio of the main catalyst to the cocatalyst is 1:100-5,000. The catalyst has high activity and high polymer molecular weight; when the catalyst is applied to copolymerization of ethylene and alpha-olefin or a polar alkene monomer, the insertion rate of the alpha-olefin or the polar alkene monomer is high; and the main catalyst has high stability and small monoamine oxidase (MAO) using amount.

The invention relates to a fluorescent testing method of monoamine oxidase activity. It forms fluorescent material, detects fluorescent intensity and achieves monoamine oxidase activity data by using monoamine oxidase to hydrolyze fluorescent probe. The probe is coumarin compound and its structure as shown in (I), in which R1 and R2 are alkyl of H or C1-C6 independently. Preparation of probe in this invention just needs simple device, convenient operation and easily gained materials. The prepared probe has stable property and high purity (above 99%). Compared to the current method for testing monoamine oxidase activity, its accuracy, sensitivity and testing velocity are all improved.

The invention provides novel compounds of formulae I and II:

that are monoamine oxidase-B inhibitors, which can be useful in treating obesity, diabetes, and/or cardiometabolic disorders (e.g., hypertension, dyslipidemias, high blood pressure, and insulin resistance).

The invention relates to a tacrine-coumarin derivative containing triazole and an application of the derivative and belongs to the technical field of biological medicine. The derivative comprises compounds represented as a formula I and pharmaceutically acceptable salt, and three preparation methods of the derivative are provided; a pharmacological experiment proves that the derivative is acetylcholinesterase inhibitor and can inhibit activity of acetylcholin esterase, butyrylcholine esterase and MAO (monoamine oxidase), and meanwhile, the derivative can inhibit autopolymerization of beta-amyloid protein, delay hydrolysis of acetyl choline and autopolymerization of beta-amyloid protein, improve the function of acetyl choline on synapsis and be used for treating Alzheimer's disease effectively.

A method for treatment of neurodegenerative disease conditions stemming from multiple sclerosis, aging, autoimmune diseases and fibromyalgia. A compound effective to increase neuronal metabolism of histamine to a histamine H₂ agonist is administered in an amount sufficient to stimulate production of cyclic AMP at a level which is sufficient to maintain myelin against undergoing self-degeneration. The compound is selected from the group consisting of histamine M-methyltransferase, monoamineoxidase-A, monoamineoxidase-A agonists and histamine H₃ antagonists. The histamine M-methyltransferase may be administered to increase neuronal metabolism of histamine to tele-methylhistamine, whereas the monoamineoxidase-A or monoamineoxidase-A agonist may be administered so as to increase neuronal metabolism of telemethylhistamine to an H₂ agonist. Separately or in conjunction with the others, the histamine H₃ antagonist may be administered so as to inhibit metabolism of the telemethylhistamine to an H₃ agonist, thereby increasing metabolism of the telemethylhistamine to an H₂ agonist. The increased histamine H₂ agonist levels reduce demyelination and the symptoms that are associated with these conditions.

The invention provides a fleece-flower root life-prolonging tablet for treating baldness according to the theory that the baldness is treated in need of treating liver and kidney firstly. The formula of the fleece-flower root life-prolonging tablet is as follows according to the weight ratio: 300-400 parts of polygonum multiflorum, 18-22 parts of rehmannia, 14-20 parts of semen sesami nigrum, 30-50 parts of the root of bidentate achyranthes, 150-200 parts of mulberry, 30-50 parts of fructus ligustri lucidi, 200-250 parts of eclipta, 30-50 parts of folium mori, 70-90 parts of semen cuscutae, 230-280 parts of fructus rosae laevigatae, 30-50 parts of fructus psoraleae, 60-100 parts of phlomis bracteosa royle and 15-25 parts of honeysuckle. The modern pharmacology research shows that the fleece-flower root life-prolonging tablet has the functions of resisting free radicals, preventing lipid peroxidation, reducing activity of monoamine oxidase, enhancing the function of adrenal gland and the like; in addition, the fleece-flower root life-prolonging tablet can lessen the formation of experimental atheromatous plaques and lipid deposition, so as to exert the functions of reducing blood fat and resisting atherosclerosis.

The invention discloses 2,3-dihydrobenzofuran derivatives shown in a formula (I), intermediates for preparing the derivatives and a preparation method of the derivatives. In the formula (I), R1 is shown in formulae (II) and (III), wherein R5 and R6 are independently substituted phenyl; R2 and R4 are independently benzoyl or substituted benzoyl; and R3 is H, hydroxy, halogen, nitro or C1-C3 alkyl. In the invention, novel 2-phenylseleno-methyl-2,3-dihydrobenzofuran compounds containing organic selenium and five-membered nitrogen-containing heterocycles are provided; the synthesis process is simple, is high in yield and is easy to industrialize; and the compounds are depressant medicaments with significant inhibition on monoamine oxidase activity, thereby providing a research basis for screening new medicaments such as antidepressant medicaments, anti-Parkinson medicaments and the like.

The invention relates to an integrated detection reaction orifice plate and protein chip reagent box for detecting six indexes of diagnosis, forecast and prognosis of hepatitis, hepatocirrhosis and liver cancer, including hepatitis B virus surface antigen (HBsAg), hepatitis C virus antibody (HCVAb), alpha-fetoprotein (AFP), alpha-L-Fucosidase (AFU), mono amine oxidase (MAO), hyaluronic acid (HA). And the orifice plate comprises a substrate and reaction orifices on the substrate, where the reaction orifices comprise 2-384 sample orifices and 2-8 standard product orifices, and at the bottom of each reaction orifice is solid carrier coated with micro lattice of HBsAg, HCVAg, AFP, AFU,MAO,and HA antigens /antibodies or more. And the reaction plate and reagent can simply and conveniently, quickly and accurately implement simultaneous detection of the six indexes of diagnosis, forecast and prognosis of hepatitis, hepatocirrhosis and liver cancer for many persons.

The invention relates to the field of medicinal chemistry, in particular to a 4-hydroxycoumarin-3-Schiff base compound (I). Pharmacodynamic experiments prove that the compound is a multifunctional monoamine oxidase (MAO) inhibitor, has better effects of inhibiting beta-amyloid protein (A beta) aggregation, metal ion chelation, oxidation resistance and neuroprotection, and can be used for curing Alzheimer's disease.

The invention provides a derivative of coumarin parallel 3-hydroxypyridine-4-ketone, pharmaceutically acceptable salts of the derivative and or pharmaceutically acceptable carriers of the derivative in the preparation of drugs for treating Alzheimer's disease and Parkinson's disease or through single inhibition of monoamine oxidase activity, ability to chelate metal iron ions or through simultaneous inhibition of monoamine oxidase activity and ability to chelate the metal iron ions.

The invention discloses a compound shown as a formula (i1) or a formula (i2) and a preparing method thereof. The compound can be adopted as a fluorescence probe and applied for monoamines oxidase activity fluorescence detection. The compound has characteristics of simple preparation equipment, simple operation processes, commercialized and easily available raw materials, stable properties of the compound as the fluorescence probe for the monoamines oxidase, and high purity. When the fluorescence probe is applied for the monoamines oxidase activity fluorescence detection method, the accuracy and the sensitivity are largely improved than those of basic methods used in the prior art for detection the monoamines oxidase activity.

The invention relates to the application of a calcium disodium edentate and corticosteroid compound preparation in preparing medicine capable of inhibiting connective tissue growth factors and monoamine oxidase, and provides a compound preparation prepared from calcium disodium edentate and corticosteroid, which comprises the calcium disodium edentate which serves as the active component, the corticosteroid and one or more medicinal auxiliary ingredients; and the compound preparation contains the calcium disodium edentate in the weight percentage of 2 to 20 percent, glucocorticoid in the weight percentage of 0.01 to 0.1 percent, and the auxiliary ingredients which can be used for injection.

The invention discloses a composition for dredging breast microcirculation to maintain autologous glandular cells and a preparation method thereof. The composition takes oligopeptide-1 and multiple medicinal plant extracts as main components, and can balance the ratio of in vivo estradiol to progesterone mainly by reducing hormones released by autologous gonadotropin; moreover, the composition can promote metabolism of human breast tissues, inhibit the activity of monoamine oxidase in breast tissues and synthesis of collagenous fibers, and inhibit abnormal hyperplasia of endothelial growth factors and basic fibroblast growth factors of breast blood vessels. The composition can effectively dredge breast channels and collaterals, improve breast microcirculation, discharge toxins accumulated in breasts, eliminate breast catheter hydrops and hyperemia edema, and restore the health and vitality of breasts. The composition has the effects of dredging, discharging, repairing, nourishing and strengthening mammary glands to achieve breast strengthening, beautification and protection, has the effects of preventing mammary diseases and breast healthcare, can realize 'preventive treatment of diseases', and can improve the sub-health state of breasts while preventing the diseases.