92 results about "Tryptamine" patented technology

The invention relates to a preparation method of tryptanthrin compound and a new application of tryptanthrin compound in preparing indoleamine-2,3-dioxygenase (IDO) inhibitor, in particular to an application of tryptanthrin compound in preparing IDO inhibitor and in preparing medicine for preventing and/or treating diseases having pathological characteristics of tryptophan metabolic disturbance mediated by IDO. The structure of the tryptanthrin compound is shown in formula A in the description, wherein R1 and R2 are respectively and independently selected from hydrogen, nitryl, C1 to C5 alkyl, halogen or piperazinyl. The tryptanthrin compound can be used as an IDO inhibitor with high activity and is used for treating diseases having pathological characteristics of tryptophan metabolic disturbance mediated by IDO such as tumor, cancer, Alzheimer disease, autoimmune disease, cataract, mental block, tristimania, anxiety neurosis, acquired immure deficiency syndrome (AIDS) and other serious diseases, and as a medicinal resource which is very difficult to get, the tryptanthrin compound has good potential on researching and developing new medicine.

The present invention discloses the application of bakuchiol compound in preparing medicine for treating psychogenic diseases and neurogenic diseases. Extracorporeal experiment and animal experiment show that the bakuchiol compound can suppressing dopamine transport protein, noradrenalin transport protein and 5-hydroxy tryptamine transport protein selectively, and no influence on gamma-aminobutyric acid transport protein and L-glytamic acid transport protein, no cytotoxicity, and antidepressant effect higher than available antidepressant medicine amfebutamoe hydrochloride. Therefore, the bakuchiol compound has excellent marketability in preparing medicine for treating psychogenic diseases and neurogenic diseases.

The invention discloses an anti-insomnia composition, an application of the composition, a multi-phase pulse immediate-release preparation prepared by use of the composition and a preparation method of the preparation. The anti-insomnia composition consists of a component A and a component B, wherein the component A is one or more of melatonin, melatonin analogue and corresponding salt, melatonin receptor stimulant, 5-hydroxytryptamine 2C, receptor antagonist and 5-HTP (5-hydroxytryptophan); the component B is one or more of petroselinum neapolitanum extract, melissa extract, tuber fleeceflower stem extract, chamomile extract, passion flower extract, radix paeoniae alba extract, manyprickle acanthopanax extract, polygala tenuifolia extract, hyperforin perforatum extract, flos albiziae extract, lily extract and prunella vulgaris extract. The composition and the multi-phase pulse immediate-release preparation prepared by use of the composition have the characteristic of better anti-insomnia effect than a common melatonin preparation, and can effectively solve and improve the problem of difficult sleep of human or mammals while effectively solving and improving the insomnia problems such as light sleep or dreaminess or early awakening or difficult sleep after wakeup of human or mammals.

The invention discloses enzyme for degrading biogenic amine in soy sauce, and belongs to the technical field of fermentation. A sequence of multi-copper oxidase crude enzyme provided by the inventionis as shown in SEQ ID NO.1. The enzyme disclosed by the invention has different degrees of degradation functions on biogenic amine of tryptamine, phenylethylamine, putrescine, cadaverine, histamine, tyramine and spermidine in the soy sauce, wherein the concentration of the tyramine of which the content in the soy sauce is the most is 540.71 mg/L. After adding the multi-copper oxidase crude enzymeprovided by the invention, the content of the biogenic amines is reduced by 100 mg/L within 24 hours; compared with an existing technology for reducing the content of the biogenic amine by 58.57 mg/Lby adding pure enzyme in a biogenic amine mixed solution for 24 hours, the degradation time is short, and the effect is good.

The invention relates to a method for producing tryptamine ketones and the derivatives shown in formula (I), wherein the compounds are obtained through reaction between indole quinines or the derivatives and isatoic anhydrides or the derivatives. The invention is characterized in that the solvent is selected from lower alcohols, chloroform, carbon tetrachloride, 1, 2-dichloroethane, tetrahydrofuran, dioxane, toluene, xylene, DMF and DMSO of C2-C5; the catalyst is inorganic base or organic base; R1, and R2 is selected from hydrogen, hydroxyl and alkoxy, amino of C1-C6, halogen, alkyla, amide, substituted aminomethyl C1-C8 or amide methyl.

The invention discloses a rapid analysis method of biogenic amine in fish. The common biogenic amine (nine types of biogenic amine comprising agmatine, histamine, tyramine, spermine, spermidine, 2-phenylethylamine, tryptamine, cadaverine and putrescine) is analyzed in a targeted manner by taking 5-sulfosalicylic acid as an extraction solvent, adopting bead agitating and grinding as an extraction method, taking benzoyl chloride as a derivatization reagent and adopting an LC (liquid chromatogram)-triple tandem quadrupole mass spectrometry. The biogenic amine is detected in a multi-reactions monitoring manner by taking ion pairs with optimum response, which are obtained by optimization, as quantitative ion pairs and taking ion pairs with following response as auxiliary qualitative ion pairs.According to the method, the sample extraction time and the biogenic amine derivation time can be greatly shortened, so that the analysis time of the whole analysis process is greatly shortened. The analysis method has the advantages of being simple in sample pretreatment, rapid in derivation, high in detection sensitivity, high in repeatability and the like.

The invention discloses novel multicopper oxidase and application thereof to biogenic amine degradation, and belongs to the technical field of molecular biology. The optimum pH of the multicopper oxidase is 3.5, the optimum temperature is 50 DEG C, and copper ions can promote enzyme activity and ensure that enzyme activity is improved by two times; the novel multicopper oxidase can tolerate 18 percent NaCl, and is obviously superior to the conventional multicopper oxidase. Multicopper oxidase recombinase has high biogenic amine degradation performance, is broad in degradation spectrum, can degrade tryptamine, phenylethylamine, putrescine, cadaverine, histamine, tyramine and spermidine within 24h, ensures that the degradation rate to total amine in a biogenic amine model system reaches 39 percent, and has the best degradation effect on histamine; the novel multicopper oxidase ensures that the degradation rate to total amine in soy sauce reaches 13 percent, and has obvious degradation effect on putrescine and phenylethylamine. The multicopper oxidase is beneficial to improvement of safety of fermented food.

The invention discloses a method for chiral spirocyclic phosphoric acid catalytic synthesis of an optically active benzoazepinoindole derivative. The method comprises the steps: with N[b]-alpha-naphthyl methyl tryptamine and aldehyde as raw materials, chiral spirocyclic phosphoric acid as a catalyst and benzene as a reaction solvent, in the presence of a 4-angstrom molecular sieve powder, and under the protection of nitrogen gas, a reaction is carried out for 3-50 hours at the temperature of 20-40 DEG C, and the optically active tetrahydro-beta-carboline derivative is obtained by a column chromatography purification and separation process. The method has the advantages of mild reaction conditions, simple process and convenient operation; and the obtained optically active benzoazepinoindole derivative has good potential biological activity, and can be used as a drug synthesis intermediate.

The invention discloses a synthesis method of panobinostat. The synthesis method comprises a step of synthesizing 2-methyl tryptamine or hydrochloride thereof, namely taking 2-methylindole as a raw material, conducting reaction with chloroacetyl chloride or bromoacetyl bromide, and conducting reaction with potassium phthalimide to obtain the 2-methyl tryptamine. According to the technical scheme adopted by the invention, influence of toxic raw materials on the safety of a panobinostat product is avoided; meanwhile, the invention provides the synthesis method applicable to industrial production.

The invention discloses an organic chemical synthesis method, in particular a method for chemically synthesizing evodiamine. Indole acetonitrile is taken as a raw material, and the method comprises the following steps of: performing catalytic hydrogenation on palladium carbon to prepare tryptamine; mixing with ethyl formate to form solution for a formylation reaction, and dissolving the reactants in solution of dichloromethane; adding trifluoroacetic acid for cyclization, and preparing another intermediate in a reflux state from N-methylanthranilic acid and excessive ethyl chloroformate; and finally, subjecting two intermediates to condensation reaction in a non-polar solvent system. The method for chemically synthesizing the evodiamine has the advantages of rich raw material source, low price of the raw material, capacities of improving the yield and fulfilling the aim of reducing the production cost by optimizing reaction conditions, environmental friendliness and suitability for large-scale industrial production. The product can be widely applied to pharmaceutical industry.

The invention discloses a method for controlling biogenic amine content of soy sauce by adopting potassium sorbate and belongs to the technical field of soy sauce production quality control. Degreasedsoybeans and wheat are subjected to koji making in a closed koji making machine, finished koji and a NaCl solution are uniformly mixed and fermented, and potassium sorbate is added in a bean sauce mash fermentation process. Potassium sorbate can obviously inhibit production of putrescine, cadaverine, histamine, tyramine, spermidine, spermine, tryptamine, phenylethylamine, 5-hydroxytryptamine andagmatine and has less influence on production of characteristic indexes such as soluble salt-free solids, total nitrogen, amino acid nitrogen and like in soy sauce. According to the method, productionof multiple kinds of biogenic amines in a soy sauce brewing process can be remarkably reduced on the basis that quality of the brewed soy sauce is not affected.

The invention belongs to a method for measuring biogenic amine in tobaccos. The method includes that liquid-liquid extraction-tandem solid-phase extraction are used as pretreatment means, and the seven types of biogenic amine (including putrescine, cadaverine, histamine, tyramine, spermine, spermidine and tryptamine) in the tobaccos are measured by the aid of high-performance liquid chromatography-mass spectrometry/mass spectrometry (HPLC-MS/MS) processes. Compared with the literature, the method has the advantages that the method suitable for measuring the biogenic amine in the tobaccos is created; the created method is simple and reliable and can be applied to detecting the biogenic amine in the tobaccos; samples can be easily, convenient and quickly analyzed by the aid of the method, and the method is low in detection limit, high in sensitivity and good in repeatability and recovery rate.

The invention firstly establishes an ultrahigh-efficiency liquid chromatography method which is used for quickly extracting and determining nine medicinal biogenic amines in the kudzu vine root whichis a medicine-and-food homologous product. The nine biogenic amines comprise tryptamine, phenylethylamine, putrescine, cadaverine, histamine, octopamine, tyramine, spermidine and spermine. After breaking a kudzu vine root sample, extraction by 0.4mol/L hydrochloric acid is utilized. Derivatization is performed in front of a dansyl chloride column. Ammoniacal liquor is added for terminating reaction, and acetonitrile is added for realizing a constant volume. A UPLC chromatographic column is utilized. Ammonium acetate and acetonitrile are used as mobile phase for performing gradient elution. A diode array detector is utilized for detecting in a wavelength of 254nm. The detecting method has an excellent linear relation. The sample recovery rate is 75.6-97.2%, and the relative standard deviation is 0.12-5.32%. The method limit of quantitation of the nine biogenic amines are respectively 10mg/kg. The method has advantages of simple operation, high speed and high sensitivity. The method canbe used for simultaneously measuring the residual amount of nine biogenic amines in the animal and botanical food such as kudzu vine root.

The invention discloses a novel MCO (multicopper oxidase) with the function of efficient degradation of histamine, and belongs to the technical field of molecular biology. The sequence of the MCO is shown as SEQ ID NO.1. The enzyme has higher histamine degradation performance, is wide in degradation spectrum, can degrade tryptamine, phenylethylamine, putrescine, cadaverine, histamine, tyramine andspermidine, particularly has good degradation effect on histamine, has histamine degradation rate of 82% within 24 h and has important industrial application potential.

The invention discloses a method for preparing N-Acetyl-5-Methoxyl Tryptamine, which comprises the steps that: 5-Methoxyl Tryptamine and acetic anhydride are used as raw materials and absolute ethanol is used as a solvent; the N-Acetyl-5-Methoxyl Tryptamine is obtained by ordinary acetylation. The preparation method uses the absolute ethanol for replacing dichloromethane as the solvent, thus being safe, nontoxic, and the like, and reducing the pollution or contamination to human bodies or surrounding environment to the utmost extent; therefore, the obtained product is safer and can effectively improve the sleeping quality of patients.

The invention provides a method for synthesizing 3-oxo-pyrrol[2,3-b]indole compounds, which comprises the following step: carrying out cyclization-free radical quenching reaction on tryptamine or tryptophane and derivatives thereof as raw materials under the actions of catalytic amounts of metal oxidizer and free radical trapping agent to generate a series of 3-oxo-pyrrol[2,3-b]indole compounds by a one-step process. The method is simple to operate, has the advantages of cheap and accessible raw materials and reagents, high reaction yield and high reaction regioselectivity and stereoselectivity, overcomes the defects of multiple reaction steps, multiple side reactions, expensive reagents and the like, and is suitable for synthesizing various 3-oxo-pyrrol[2,3-b]indole compounds.

The invention discloses a method for controlling biogenic amine content of soy sauce by adopting a red bayberry leaf extract, and belongs to the technical field of soy sauce production quality control. The method for controlling the biogenic amine content of the soy sauce by adopting the red bayberry leaf extract comprises the following steps: preparing koji by putting degreased soybeans and wheatin a sealed koji making machine; uniformly mixing the prepared koji with a NaCl solution, and carrying out fermentation; and adding the red bayberry leaf extract during soy sauce paste fermentation process. The method for controlling the biogenic amine content of the soy sauce by adopting the red bayberry leaf extract is capable of obviously inhibiting production of putrescine, cadaverine, histamine, tyramine, spermidine, spermine, tryptamine and phenylethylamine; moreover, the method has no impact on characteristic indexes, including soluble salt-free solids, total nitrogen, amino acid nitrogen and the like, of soy sauce. The method for controlling the biogenic amine content of the soy sauce by adopting the red bayberry leaf extract is capable of significantly reducing production of a plurality of biogenic amines during fermentation processes of soy sauce under the premise of causing no influence on soy sauce quality.

The present disclosure provides compositions that inhibit the SH2-containing inositol 5′-phosphatase (SHIP), as well as methods using such compositions for use in treating or ameliorating the effects of a medical condition in a subject.

The invention relates to a chromatography medium adopting tryptamine as a functional ligand. The chromatography medium comprises a chromatography matrix and a ligand, wherein the chromatography matrixis hydrophilic porous microspheres, and the ligand is trytamine coupled after being activated by bromoacetyl bromide. The chromatography medium is high in antibody adsorption capacity, the saturatedadsorption capacity can reach 140mg/ml of wet medium, and the processing capacity is high; and the medium is stable in characteristics, and the ligand is activated and coupled by adopting the allyl bromide, so that the ligand of the medium is stable, and convenience in cleaning and regeneration can be realized.

The present invention provides for a composition comprising a tryptamine based drug that acts as a 5-hydroxytryptamine-1 inhibitor in an amount sufficient to reduce the effects of psoriasis and wherein the composition is formulated for topical or oral administration.

The invention discloses an oyster mushroom culture medium manufactured by using corncobs and pig manures, which is characterized in that a main ingredient of the culture medium is composed of the following raw materials by weight: 75-90 kg of corncobs, 2-8 kg of pig manures, 2-8 kg of chicken manures, 2-10 kg of cow dung, and 130 kg of water. The oyster mushroom culture medium disclosed by the invention has the advantages that (1) oyster mushrooms produced in the oyster mushroom culture medium disclosed by the invention are green foods which are good in taste and fresh in quality, more nutritive than ordinary mushrooms, good in toughness, and not easy to break; (2) pig manures, chicken manures and cow dung contain a large number of harmful substances such as ova, harmful bacteria, viruses, lactic acid, butyric acid, carbon dioxide, butyl amine, methane, histamine, tryptamine, ammonia, indole, phenols, skatole, sulphate, hydrogen sulfide and the like, and pollute the environment if being directly used, but after the pig manures, the chicken manures and the cow dung are used by the oyster mushroom culture medium, harmful substances are changed into things of value.

The invention belongs to the technical field of functional beverages, and particularly relates to a plant beverage for improving sleep and a preparation method thereof. The plant beverage comprises the following raw materials in parts by weight: 6-14 parts of pseudo-ginseng flowers, 8-16 parts of spina date seeds, 7-13 parts of rhizoma polygonati, 16-24 parts of lily bulbs, 18-26 parts of lotus seeds, 20-28 parts of Chinese dates, 17-23 parts of Chinese wolfberry fruits, 8-10 parts of fish collagen, 4-6 parts of gamma-amino butyric acid, 1-3 parts of tea leaf theanine, 8-10 parts of xylitol and 0.1-0.3 part of potassium sorbate. Through the synergistic effect of gamma-amino butyric acid, jujuboside in spina date seeds and magnesium, secretion of 5-hydroxyl tryptamine and melatonin is promoted, and the sleep problem of anxiety insomnia patients is remarkably improved.

The invention discloses a green synthesis method for beta-carboline heterocyclic compounds. The green synthesis method includes that the beta-carboline heterocyclic compounds are made of alcohols compounds, oxidative condensation, cyclization and re-oxidation one-pot cascade reaction is carried out on tryptamines compounds and alcohol in oxygen under the catalytic effects of catalysts TEMPO and catalysts TBN to obtain the beta-carboline heterocyclic compounds, the reaction temperatures range from 40 DEG C to 120 DEG C, and the reaction time ranges from 6 hours to 48 hours. The green synthesismethod has the advantages that inexpensive, easily available, stable and low-toxicity alcohols which can come from wide sources are used as the raw materials for the beta-carboline heterocyclic compounds, the aerobic oxidative condensation, cyclization and re-oxidation cascade reaction is carried out on the tryptamines compounds and the alcohol under the synergistic catalytic effects of the catalysts TEMPO and the catalysts TBN and acetic acid solvent conditions to prepare the beta-carboline heterocyclic compounds, target products are high in selectivity, a byproduct is water, and accordinglythe green synthesis method is high in efficiency and free of pollution.