223 results about "Phase synthesis" patented technology

According to the portable solid-phase synthesis reaction device, in the portable solid-phase synthesis reaction device, a support module comprises a synchronous belt lead screw nut; the motor driving module is installed on one side of the upper end edge of the support module to serve as a power source component for adjusting the size of the composite column cavity, the motor driving module comprises a stepping motor and a synchronous wheel, the synchronous wheel is installed on an output shaft of the stepping motor, and the synchronous belt is arranged on the synchronous wheel and the synchronous belt lead screw nut in a sleeving mode; the lead screw lifting module is installed on the column top support to serve as an execution component for adjusting the size of the composite column cavity and comprises a transmission lead screw, a piston unit is installed at the lower end of the transmission lead screw, and the transmission lead screw is in threaded connection with a synchronous belt lead screw nut. The synthesis column body module is mounted in the middle between a column top support and a bottom plate of the support module to serve as a synthesis carrier to be filled and a solid-phase synthesis reaction vessel, and the synthesis column body module comprises a synthesis column.

The invention discloses a hexapeptide TE6 with xanthine oxidase inhibitory activity and a preparation method and application thereof, and belongs to the technical field of small molecule peptides. The amino acid sequence of the hexapeptide TE6 is TIATVE, and the hexapeptide TE6 can be prepared through a solid-phase synthesis method and an enzymolysis method. The hexapeptide TE6 is identified from a solieria cavaleriei proteolysis solution and has potential interaction with xanthine oxidase, under the concentration of 0.1 mg / mL, the xanthine oxidase inhibition rate is 44.74%, and compared with goose carnosine (the xanthine oxidase inhibition rate is 36.03%), the xanthine oxidase inhibition rate is remarkably increased (plt; 0.05), which is stronger in xanthine oxidase inhibitory activity, and can be used for preparing a preparation for inhibiting xanthine oxidase activity and relieving hyperuricemia.

The invention relates to a molecular tag DMDPM compound, a preparation method thereof and application of the molecular tag DMDPM compound in assisting homogeneous synthesis of heptapeptide H6K, and belongs to the technical field of organic synthesis. The molecular tag DMDPM compound is 2, 4-dimethoxy-4 '-diphenylphosphinyl oxydiphenyl alcohol, and the molecular tag DMDPM compound is 2, 4-dimethoxy-4'-diphenylphosphinyl The method has the advantages of a liquid-phase synthesis method and a solid-phase synthesis method, H6K can be simply, quickly, economically and efficiently synthesized and prepared, and a 2, 4-dimethoxy-4 '-diphenylphosphinyloxy diphenyl alcohol small-molecule auxiliary group (also called as a carrier) can be recycled and directly reused, so that raw material waste is reduced, waste pollution is reduced, the cost is saved, and environmental protection is facilitated.

The present application relates to the technical field of dielectric ceramic powder preparation, and particularly relates to a multilayer ceramic capacitor, a high-activity nano-barium titanate powder for the multilayer ceramic capacitor and a preparation method of the high-activity nano-barium titanate powder, the method comprising the following steps: (1) reacting a soluble barium salt with a precipitator to obtain barium carbonate precursor particles with high specific surface area; (2) uniformly coating nano-titanium dioxide particles on the surface of the barium carbonate precursor particles by using a supercritical fluid flash technology to form a composite precursor; and (3) performing a solid-phase synthesis reaction on the composite precursor and sintering to obtain nano-barium titanate powder. The present application, through the synergistic effect of the two means of "high-activity precursor preparation" and "nano-level uniform coating", prepares a composite precursor with extremely high specific surface area, surface energy and micro-uniformity, effectively reduces the heat sintering temperature, suppresses abnormal grain growth and lattice distortion, and significantly improves the tetragonality of the nano-barium titanate powder.

The invention relates to a method for semi-solid-phase synthesis of a polycyclic compound and an intermediate, a long chain is synthesized through solid phase, then two-step ring closing is performed to form a key intermediate, and simple derivation is performed on the basis of the key intermediate to obtain a PCSK9 antagonist compound. According to the invention, starting materials for solid-phase synthesis are selected, steric hindrance is effectively avoided, and solid-phase reaction and subsequent liquid-phase correlation cyclization can be smoothly carried out, so that the yield is improved, and the cost is reduced.

The invention relates to a ligand-induced room-temperature ultrathin magnetic nanosheet synthesis preparation method, which comprises: mixing a metal-ligand solution and an anion-ligand solution, and carrying out a heating reaction to obtain a ligand-induced room-temperature ultrathin magnetic nanosheet, wherein the metal-ligand solution comprises a Cu source, a Cr source and a first ligand; the anion-ligand solution comprises an anion X source and a second ligand; x is Se or Te; the first ligand is selected from one or two of oleylamine or oleyl alcohol; the second ligand is selected from one of oleylamine or tri-n-octylphosphine. Compared with the prior art, the method has the advantages that specific crystallographic orientation is stabilized by adjusting the adsorption capacity of ligands and surface ions in an organic liquid phase synthesis mode, anisotropic growth is guided, and the problems that in the prior art, room-temperature ultrathin nanosheet preparation excessively depends on substrate growth, and the steps are tedious are solved.

The invention discloses an oligonucleotide synthesis process of a sulfo-PMO structure. In the oligonucleotide synthesis process of the sulfo-PMO structure, the molecular structural formula of sulfo-PMO is shown in the specification. According to the invention, the molecular structure of thio-PMO is specifically limited, and the synthesis of nucleotide phosphate amide and (thio) phosphoric acid amide in the solid-phase synthesis oligonucleotide is carried out along the direction from 5'to 3 ', that is, in each cycle period, the O5'or O6' position of the nucleotide phosphate amide and (thio) phosphoric acid amide monomer is firstly subjected to coupling reaction, and then the protecting group is removed at the O3 'or N3' position, so that the oligonucleotide phosphate amide and (thio) phosphoric acid amide are obtained. And releasing active hydroxyl or amino / amido to enter the next cycle. The protecting group adopted by the sulfo-PMO molecule is consistent with the protecting groups of other nucleotides, so that the conversion rate of each step of coupling reaction can be conveniently detected on line.

The invention discloses a long-afterglow self-luminous material based on multi-element rare earth synergistic sensitization and a preparation method thereof. SrAlO is used as a matrix, trap level distribution is optimized through ternary rare earth synergistic doping according to the molar ratio of Eu to Dy to Nd being 1: (0.4-0.6): (0.2-0.4), and a ZnO nanorod array is grown on the surface of a light-emitting core in an in-situ epitaxial mode to improve the light extraction efficiency; and a hydrophobic modified SiO core-shell coating layer with an ordered mesoporous channel is combined, and oxygen diffusion is promoted by utilizing a nanopore channel so as to accelerate trap regeneration and synchronously inhibit non-radiative recombination. The afterglow time of the material is not less than 8 hours, and the afterglow retention rate after aging at 60 DEG C is not less than 80%. A solid-phase synthesis process and red mud / fly ash industrial solid waste raw materials are adopted, and the carbon emission intensity is smaller than or equal to 6 kgCO / kg. The material can be widely applied to the fields of green traffic infrastructures such as expressways and tunnels.

The application relates to a synthesis method of an anti-freezing glycopeptide polypeptide and belongs to the technical field of polypeptide drug synthesis. The method comprises the following steps: 2-CL-Resin is used as a carrier resin, under the condition of adding an activating agent, the carrier resin and alanine are coupled to obtain Fmoc-Ala-2-CL-Resin; according to the amino acid sequence of the anti-freezing glycopeptide, other amino acids are sequentially coupled through a solid-phase synthesis method; after a protecting group is removed and the carrier resin is cleaved, the anti-freezing glycopeptide crude peptide is obtained; and after purification, salt conversion and freeze-drying, the anti-freezing glycopeptide polypeptide is obtained. The method has the advantages of short synthesis period, low cost, easy post-treatment, few by-products, high product yield, facilitation of large-scale production of the anti-freezing glycopeptide, and considerable economic applicative value and wide application prospect.

The invention discloses a low-temperature solid-phase synthesis cobalt blue pigment preparation method, which comprises: (1) placing a cobalt source, an aluminum source and an inert template dispersant in a planetary ball mill, carrying out ball milling, and drying to obtain nanometer composite precursor powder; (2) adding a mixture of a lithium source and a boron source into the nano composite precursor obtained in the step (1), putting the mixture into a mortar, and mechanically mixing to obtain a mixed material; and (3) putting the mixed material obtained in the step (2) into a muffle furnace, melting and calcining, cooling to room temperature along with the furnace, grinding, washing with hot water, and drying to obtain cobalt blue pigment powder. According to the method, the synthesis temperature is low, particle coarsening and sintering caused by high temperature are avoided, the energy consumption is low, the process is green, and the obtained cobalt blue pigment is pure in chromaticity, large in specific surface area and excellent in thermal stability.

The invention discloses a low-temperature plasma modified efficient hydrogen evolution catalyst. The method comprises the following steps: preparing a nano core-shell structure catalyst with uniform size through liquid-phase synthesis and layer-by-layer self-assembly, and introducing vacancies, defects and other unsaturated active sites on the surface of the nano core-shell structure catalyst; and then nitrogen and the like are used as a reaction atmosphere of a plasma chamber, and the surface of the catalyst is treated through a low-temperature plasma technology for catalyst performance regulation and control. The method has the advantages of simple process, low energy consumption, no need of adding extra chemical reagents, environmental friendliness and the like, and has a good application prospect. The preparation and regulation method of the electrocatalyst can be suitable for application of an electrocatalytic efficient hydrogen evolution catalyst. The material regulated and controlled by the plasma has higher current density and lower overpotential in hydrogen evolution reaction, and shows more excellent electrocatalytic activity and stability.

Provided is a method for producing a nickel powder with which it is possible to suppress the generation of linked particles in a liquid-phase synthesis method without hindering the reduction reaction of a nickel salt. A method for producing a nickel powder, the method including a step for starting a nickel precipitation reaction in a reaction solution in which a nickel salt, a metal having a lower ionization tendency than nickel or a salt thereof, a reducing agent, an alkali metal hydroxide, a sulfonium salt, and water are mixed, the sulfonium salt being used in an amount of 100 mol% or more relative to the nickel in the reaction solution.

A preparation method for semaglutide. The method comprises: producing a semaglutide resin by means of a solid-phase synthesis, producing crude semaglutide by cleavage and deprotection, producing refined semaglutide by purification and freeze-drying, comprising the solid-phase synthesis of a semaglutide 1-6 peptide fragment resin, which is cleaved and purified to serve as a first peptide fragment; and synthesizing a lysine having a sidechain group at locus 20 of semaglutide to serve as a second peptide fragment. In the method, prepared is a semaglutide loci 1-6 fully protected peptide fragment, which serves as a key starting material applied in the solid-phase synthesis of semaglutide, thus reducing the generation of D-His, D-Glu, D-Thr, D-Phe racemic impurities and +Gly impurities, reducing the difficulty of coarse product purification, increasing the purity and yield of semaglutide, reducing synthesis costs, and favoring industrialized large-scale production.

The application discloses a tetrapeptide IR4 with uric acid reducing activity, and a preparation method and application thereof, and belongs to the technical field of small molecular peptides. The amino acid sequence of the tetrapeptide IR4 is IDWR, and the tetrapeptide IR4 can be prepared by a solid-phase synthesis method and an enzymatic hydrolysis method. The tetrapeptide IR4 is identified from a porphyra haitanensis protease hydrolysate, has potential interaction with xanthine oxidase, and can reduce the uric acid content of zebrafish by 33.6% (to 5.93+ / -0.47 mu mol / g protein) at a concentration of 100 mu g / mL. Compared with an anserine (which can reduce the uric acid content of zebrafish by 25.7%), the tetrapeptide IR4 has better uric acid reducing activity. Compared with allopurinol (which can reduce the uric acid content of zebrafish to 4.61+ / -1.11 mu mol / g protein), the uric acid reducing ability of the tetrapeptide IR4 and the allopurinol has no significant difference. The tetrapeptide IR4 can be used for preparing uric acid reducing drugs and relieving hyperuricemia.

The application relates to the field of polypeptide medicine preparation, and particularly discloses a preparation method of bumenol peptide, which adopts a solid-liquid combination mode, liquid-phase synthesis of a tripeptide fragment Fmoc-Lys(Ac-Nle-Asp)-OMe, subsequent solid-phase synthesis of a cyclic heptapeptide methyl ester, cleavage, cyclization, deprotection and hydrolysis to obtain crude bumenol peptide. The cyclization site is alpha-COOH of Trp and alpha-NH2 of Lys, the reaction yield is high, and the cyclization problem between Lys and Asp in most current patents is solved. The process operation is simple, the deprotection reagent is conducive to environmental protection requirements. The crude product is easy to purify, the finished product has high yield and purity, and is suitable for industrial large-scale production.

The invention discloses a method for synthesizing biphenol in a water phase, belongs to the technical field of fine chemical engineering, and aims to solve the explosion safety risk caused by the use of an organic solvent in the conventional alkylphenol oxidative coupling process. According to the method, a phase transfer catalysis system composed of boric acid, Tween-80, dodecylphenol polyoxyethylene ether and copper chloride is adopted, water serves as a solvent, oxygen or air is introduced at the temperature of 60-90 DEG C, alkyl phenol is subjected to an oxidative coupling reaction to generate alkyl biquinone, and then biphenol is prepared through hydrogenation reduction. The method thoroughly avoids the use of an organic solvent, eliminates the hidden danger of explosion from the source, and has the advantages of high intrinsic safety, environmental friendliness and low cost.

The invention provides a device for DNA solid-phase synthesis and a preparation method of the device. The device comprises a solid-phase synthesis carrier and a micropore array which is arranged on the solid-phase synthesis carrier and is provided with a wrinkled inner wall. The pore diameter of the micropores is 70-90 [mu] m, the pore depth is 5-6 [mu] m, the inner wall roughness is 0.5-5 [mu] m, the distribution density of the micropores on the surface of the solid-phase synthesis carrier is greater than 1111 / mm < 2 >, and the reaction contact surface provided by the solid-phase synthesis carrier is further expanded; meanwhile, hydrophilic treatment and synthesis starting point grafting are carried out on the inner walls of the micropores, hydrophobic membrane coating is carried out outside the micropores, the synthesis density is increased, and the error rate of the synthesis process is reduced. According to the solid-phase synthesis device, the reaction contact area is further enlarged while the synthesis accuracy is ensured, the coupling density is increased, and a high-yield synthesis device is provided for solid-phase synthesis of DNA by a phosphoramidite method.

The application provides a preparation method and application of a high near-infrared reflective red pigment. 1‑x RE x O5; wherein RE is at least one selected from La, Ce, Pr, Nd, Sm, Eu, Gd, Dy, Y, Tm, Yb and Lu. The red pigment is obtained by doping with a rare earth element RE and using a high-temperature solid-phase synthesis method, so that the a* range of the red pigment is changed, and the redness and near-infrared reflectivity of the red pigment are improved.

A problem addressed by the present invention is to provide a method for efficiently producing a high-purity peptide compound at a high yield. It was discovered that an amino acid can be supported efficiently by a resin for solid-phase synthesis by bringing an amino acid solution including a specific solvent into contact with a resin for solid-phase synthesis swollen by a specific solvent, thereby solving the problem.

The invention belongs to the field of preparation of polypeptide drugs, and discloses a synthesis method of tilpotide, which mainly comprises the following steps: 1) taking amino resin as initial resin, and coupling with protected amino acid and polypeptide fragments by adopting a solid-phase synthesis method to obtain peptide resin of tilpotide; wherein the Glu3-Gly4 adopts a Glu-Gly dipeptide fragment, the Thr5-Phe6 adopts a Thr-Phe dipeptide fragment, the Lys20 adopts a Lys [AEA-AEA-gamma-Glu-C20] fragment, and the Gly29-Gly30 adopts a Gly-Gly dipeptide fragment; 2) cracking the peptide resin to obtain crude peptide of the tilpotide; and (3) purifying the crude peptide by reversed-phase chromatography to obtain the fine peptide of the tilpotide. The invention provides a synthesis method of telpotide, which can effectively reduce the generation of [D-Glu] racemization impurities, [D-Thr] racemization impurities, [D-Phe] racemization impurities and [+ Gly] impurities, thereby enhancing the purity and yield of the telpotide, obviously lowering the difficulty of purifying crude peptide, greatly enhancing the total yield of the telpotide on the premise of ensuring the purity of the telpotide, and lowering the production cost of the telpotide. In addition, synthesis of a plurality of fragments can be performed simultaneously, so that the synthesis time is shortened. The purity of the crude tirpotide prepared by the method can reach 86.22% or above, and the yield of the crude tirpotide is 101.51% or above. Through simple purification steps, the impurities in the tilpotide are basically removed, the purity of refined peptide can reach 99.21% or above, the maximum single impurity is lower than 0.15%, the total yield can reach 63.02% or above, the synthesis cost is reduced, and industrial mass production is facilitated.

The invention relates to the technical field of chemical preparation, in particular to a preparation method of gamma-thiocyano propyl triethoxy silane, which comprises the following steps: adding acetonitrile and tetrabutyl ammonium thiocyanate into a reaction container, dropwise adding 3-chloropropyl triethoxy silane into a four-mouth round-bottom flask while stirring, and controlling the dropwise adding time; the preparation method comprises the following steps: heating to 30-40 DEG C, reacting for 1.5-3 hours, cooling to room temperature, adding an ice-saturated sodium chloride solution into a reaction container to obtain a mixed solution, extracting the mixed solution, taking an organic layer, sequentially washing, drying and filtering, and respectively carrying out vacuum concentration and vacuum rectification on filtrate to obtain the gamma-thiocyano propyl triethoxy silane. The preparation method of the gamma-thiocyano propyl triethoxy silane provided by the invention is carried out under an anhydrous condition, so that hydrolysis and condensation side reactions of silane caused by a water-phase synthesis method are effectively avoided, meanwhile, the generation of irritant gases such as hydrogen sulfide and the like is avoided, and the preparation method is safer to operate, environment-friendly and more suitable for industrial popularization.

The invention discloses a solid-phase synthesis method of eptifibatide, and belongs to the technical field of medicine synthesis. The solid-phase synthesis step comprises the following steps: sequentially coupling amino acids on Rink Amide-AM resin by adopting a solid-phase synthesis method, treating with a removal solution, reacting with N, N '-di-BOC-1H-1-guanidino pyrazole under the condition of organic alkali, then forming a disulfide bond through iodine oxidation, cracking with a cracking solution, and purifying to obtain the eptifibatide. The organic base is N, N-diisopropylethylamine or N-methylmorpholine; the lysis solution is a mixed solution of trifluoroacetic acid, triisopropyl silane and water; the removal solution is a mixed solution of trifluoroacetic acid, triisopropyl silane and dichloromethane. According to the solid-phase synthesis method of the eptifibatide, disclosed by the invention, the resin cutting efficiency of the eptifibatide can be effectively improved, the crude peptide purity of the eptifibatide is improved, and the yield of the finally prepared eptifibatide is improved.

The invention provides a method for preparing Etelcalcetide through solid-liquid combination, which comprises the following steps: (1) carrying out amino acid coupling reaction on solid-phase carrier resin, Fmoc-D-Arg-OH, Fmoc-D-Ala-OH and Fmoc-D-Cys (Trt)-OH under the action of a dehydrating agent and a polypeptide condensing agent by adopting a solid-phase synthesis method to prepare peptide resin; (2) cracking the peptide resin and a side chain protecting group by virtue of a cracking solution, and adding 2, 2-dithiobipyridine to activate a side chain sulfydryl to obtain an activated intermediate; (3) constructing a disulfide bond from the activated intermediate in a solvent by adopting a liquid phase synthesis method, so as to prepare an Etelcalcetide crude product; and (4) purifying the crude product of the Etelcalcetide, so as to obtain the Etelcalcetide. The D-Arg amino acid which is low in price and unprotected in side chain is used, so that the method has relatively high atom economy.

The invention provides an atomic precision metal cluster containing a multi-layer ligand spherical shell and a water phase synthesis method of the atomic precision metal cluster. The aqueous phase synthesis method comprises the following steps: performing first mixing on a metal precursor aqueous solution and a ligand aqueous solution, supplementing water to obtain an initial solution, and performing second mixing; then adding a reducing agent aqueous solution to obtain a reaction mixed solution; carrying out first stirring on the reaction mixed solution, concentrating, carrying out second stirring, and supplementing water; and repeating the operations of concentration, secondary stirring and water supplementation to obtain the atom precise metal cluster containing the multilayer ligand spherical shell. The multi-layer ligand spherical shell is adopted to protect the cluster, so that the cluster core can stably exist in an extremely long time without obvious change, and co-production, storage and utilization of related clusters are facilitated; and the metal clusters with uniform size and precise atoms can be directly obtained and have the same molecular weight, so that the post-treatment step can be simplified, and the feasibility of product amplification and application is enhanced.

The application discloses low-cost sulfidized nano zero-valent iron synthesized by using pyrite as raw material and application thereof. The low-cost sulfidized nano zero-valent iron is obtained by using cheap pyrite powder as raw material, adding a small amount of anhydrous FeCl3, and through ball milling, drying and hydrogen reduction. The pyrite powder to which a small amount of anhydrous FeCl3 is added is ball milled by using zirconia ball milling beads which are easy to clean but not easy to be polluted, and then the sulfidized nano zero-valent iron is prepared after drying and reduction. By adjusting parameters such as ball powder ratio, FeCl3 addition amount, heating rate and holding time, the low-cost sulfidized nano zero-valent iron with a particle size of 200-300 nm, zero-valent iron content accounting for more than 90% of total iron content and preparation cost being 11% of that of a laboratory liquid-phase synthesis method is prepared. The material can effectively degrade trichloroethylene (TCE) and florfenicol (FF), has a small hydrogen production amount and a high electron efficiency. The preparation method is simple and easy to operate, has a low cost and has a large-scale production prospect, the degradation performance of pollutants is close to that of the laboratory-prepared sulfidized nano zero-valent iron, and far exceeds that of nano zero-valent iron, and therefore the material has a prospect of being applied to actual groundwater pollution remediation.

The present application relates to the field of fluorescent material, and disclose a kind of samarium activated garnet-based red fluorescent powder, including Na, Gd, Sm, Ga, In and Ge, wherein, the amount-of-substance ratio of metal element is Na:Gd:Sm:Ga:In:Ge=1:2-2x:2x:2:1:2, x is the doping amount of samarium in inert rare earth site, 0.01≤x<0.10, the fluorescent powder proposed in the present application utilizes new garnet matrix constructed by sodium, gadolinium, gallium, indium, germanium, and has significant advantages compared to the traditional garnet isomorphic system constructed by containing aluminum, silicon, alkaline earth metal in preparation process.By using the new matrix, the reaction temperature of solid-phase synthesis fluorescent powder is greatly reduced, and no auxiliary solvent is needed, and it can be synthesized in one step.The preparation method of the present application does not require specific pressure and atmosphere requirements during the reaction process.This means that the preparation process is more flexible, and does not require high-pressure equipment or complex atmosphere control, simplifying the operation steps, improving the efficiency and feasibility of preparation.

The invention discloses a two-dimensional material and a preparation method and application thereof, and relates to the technical field of two-dimensional materials. The preparation method of the two-dimensional material comprises the following steps: preparing a layered structure Sc2B1. 1C3.2 material by adopting a solid-phase synthesis method; and putting the Sc2B1. 1C3.2 material with the layered structure into an organic solvent, and carrying out ultrasonic stripping, so as to obtain the two-dimensional Sc2B1. 1C3.2, namely the two-dimensional material. The two-dimensional material, namely the two-dimensional Sc2B1. 1C3.2, is prepared through a method of combining high-temperature solid-phase synthesis with ultrasonic stripping, the two-dimensional Sc2B1. 1C3.2 has a wide spectral response range and can absorb light waves from ultraviolet to near-infrared regions, and the method provided by the invention is simple in process, high in product quality and suitable for large-scale production of the two-dimensional Sc2B1. 1C3.2.

The invention relates to the field of new materials, in particular to a metal organic framework material and a preparation method thereof. The preparation method of the metal organic framework material comprises the following steps: sequentially adding water and an organic ligand into a reaction kettle to form a turbid liquid, and adding a compound additive to completely dissolve the organic ligand to obtain a clear solution; sequentially adding an oxidizing agent and metal salt; heating and raising the temperature, carrying out hydrothermal reaction, and then sequentially separating, washing and drying to obtain a metal organic framework material; the compound auxiliaries are acetic acid and sodium acetate, and the molar ratio of the acetic acid to the sodium acetate is (1.5-3): 1; the molar ratio of the oxidizing agent to metal ions in the metal salt is (0.1-0.3): 1. According to the method, the yield of the MIL-101 material is increased through construction of a compound assistant system and control of a charging sequence, the water phase synthesis is relatively environment-friendly, and the metal organic framework material obtained by the method is high in yield, uniform in product granularity and suitable for industrial large-scale production.

The application discloses a pentapeptide IK5 with uric acid reducing activity as well as a preparation method and application thereof, and belongs to the technical field of small molecular peptides. The amino acid sequence of the pentapeptide IK5 is ITGYK, and the pentapeptide IK5 can be prepared by a solid-phase synthesis method and an enzymolysis method. The pentapeptide IK5 is identified from a protease enzymolysis liquid of a fine weak red winged seaweed, has potential interaction with xanthine oxidase, and can reduce the uric acid content of zebrafish by 44.4% (to 5.93+ / -0.47 mu mol / g protein) at a concentration of 100 mu g / mL. Compared with ananeine (which can reduce the uric acid content of zebrafish by 25.7%), the pentapeptide IK5 has better uric acid reducing activity. Compared with allopurinol (which can reduce the uric acid content of zebrafish to 4.61+ / -1.11 mu mol / g protein), the uric acid reducing ability of the pentapeptide IK5 and the allopurinol has no significant difference. The pentapeptide IK5 can be used for preparing uric acid reducing drugs and relieving hyperuricemia.

Provided is a method for producing a sulfide. The sulfide contains Li, P, S, and M as main constituent elements, M being at least one selected from Ge and Sn. The method for producing a sulfide, which is a liquid-phase synthesis method with which it is possible to reduce the amount of organic solvent used, comprises: a first step for obtaining a first solution by adding an Li source, an S source, and an M source to an aqueous solvent in which the amount of an organic solvent is 50 wt% or less; a second step for obtaining a second solution by adding P2S5 as a P source to the first solution; and a third step for removing the aqueous solvent in the second solution and performing crystallization by heat treatment.