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167 results about "Palmitic acid" patented technology

Palmitic acid, or hexadecanoic acid in IUPAC nomenclature, is the most common saturated fatty acid found in animals, plants and microorganisms. Its chemical formula is CH₃(CH₂)₁₄COOH, and its C:D is 16:0. As its name indicates, it is a major component of the oil from the fruit of oil palms (palm oil). Palmitic acid can also be found in meats, cheeses, butter, and other dairy products. Palmitates are the salts and esters of palmitic acid. The palmitate anion is the observed form of palmitic acid at physiologic pH (7.4).

Crystallization process of small-particle-size palmitic acid paliperidone

The invention belongs to the technical field of crystal compound preparation, and particularly relates to a crystallization process of small-particle-size palmitic acid paliperidone. The invention discloses a small-particle-size palmitic acid paliperidone crystallization process, solves the problems of large particle size, non-uniform distribution and serious agglomeration of the existing process product, and meets the requirements of long-acting injection bulk drugs. The process comprises the following steps: adding paliperidone palmitate into a specific mixed organic solvent according to a solid-to-liquid ratio of 0.04-0.09 g / g, stirring, dissolving and filtering at 65-75 DEG C, transferring into a high-pressure closed crystallizer, and pressurizing to 1.0-1.5 MPa; cooling and decompressing in sections, stirring, filtering and washing, and drying in vacuum at the temperature of 40-50 DEG C and the vacuum degree of-0.1 MPa to obtain a finished product. According to the invention, the process parameters are accurately controlled, the product is an irregular short rod-like / granular crystal, the particle size is in a normal single peak, the Dv (90) is 7.866-9.514 microns, the HPLC (High Performance Liquid Chromatography) purity is greater than or equal to 99.92%, the yield is greater than or equal to 90.25%, micronization is not needed, the process is stable, the economical efficiency is good, and the industrial application value is realized.
Owner:UNIV OF JINAN

Divalent salt resistant filtrate reducer for drilling fluid

The invention relates to the technical field of petroleum drilling fluid loss reduction, and discloses an anti-divalent salt fluid loss agent for drilling fluid, which is prepared by the following steps: step 1, beta-cyclohexylamine and 6-chloro-1-hexene are subjected to a reaction to obtain alkenyl beta-cyclohexylamine; step 2, initiating polymerization of alkenyl beta-cyclopentadiene, a hyperbranched monomer pentaerythritol triallyl ether and 2-acrylamide-2-methylpropanesulfonic acid under the action of azobis (isobutylamidine hydrochloride), so as to obtain an intermediate A; 3, 3-dimethylamino-1-propylamine and palmitic acid are subjected to a reaction, and an intermediate 2 is obtained; 4, the intermediate 2 and benzyl chloride are subjected to a reaction, and quaternary ammonium salt modified fatty acid is obtained; and 5, stirring and mixing the intermediate A, quaternary ammonium salt modified fatty acid and coupling agent modified walnut powder to obtain the divalent salt resistant filtrate reducer for the drilling fluid. The anti-divalent salt filtrate reducer for the drilling fluid has a relatively good anti-divalent salt effect.
Owner:HUIXIAN SHANSHUI CHEM TECH CO LTD

Mortar containing nano material and preparation method thereof

The invention relates to the technical field of building materials, and discloses a mortar containing a nanometer material and a preparation method thereof, the mortar comprises 70-80 parts by weight of cement, 8-12 parts by weight of fly ash, 0.4-0.5 part by weight of a polycarboxylic acid water reducer, 0.4-0.6 part by weight of hydroxypropyl methyl cellulose, 1-2 parts by weight of the nanometer material, 2-3 parts by weight of modified silk fibroin and 40-50 parts by weight of water. Wherein the modified nano silicon dioxide is modified by gamma-aminopropyltriethoxysilane, the modified cubic nano calcium carbonate is subjected to compound modification by fumaric acid, sodium stearate and palmitic acid, and the modified silk fibroin is prepared by grafting modification by bis-aminopropyl terminated polysiloxane. According to the mortar, through optimization of component matching and modification treatment of the nano material and the silk fibroin, the mechanical property, durability and crack resistance of the mortar are remarkably improved, and the cost is controllable.
Owner:中桔(广东)建材科技有限公司

Application of overexpressed product of GmDREB2A2 gene in regulating content of fatty acid in plants

This invention belongs to the field of genetic engineering technology, specifically involving GmDREB2A2 Application of genes in regulating fatty acid content in plants. Overexpression. GmDREB2A2 Gene regulation of fatty acid content in plants. This invention utilizes an exogenous gene sequence expression vector to express the coding sequence shown in SEQ ID NO.1. GmDREB2A2 Gene sequences are introduced into plants to enable GmDREB2A2 Gene overexpression. Under these conditions, the plant's linolenic acid, linoleic acid, and palmitic acid content were significantly higher than the control, while the content of eicosatrienoic acid and erucic acid was significantly reduced.
Owner:JILIN AGRICULTURAL UNIV

Fat-soluble component nano-emulsion and preparation method thereof

The invention relates to the technical field of preparation of health-care products, in particular to a fat-soluble component nano-emulsion and a preparation method thereof. The preparation method comprises the following steps: stirring and dissolving the antioxidant and the caprylic / capric triglyceride, adding the vitamin D3 and the retinyl palmitate, and stirring and dissolving to obtain an oil phase; stirring the starch sodium octenylsuccinate in purified water until the starch sodium octenylsuccinate is dissolved, adding glycerol, and uniformly stirring and mixing to obtain a water phase; adding a small amount of water phase into the oil phase, and stirring at high speed to obtain primary emulsion; adding the primary emulsion into the residual water phase, stirring at a high speed, shearing and homogenizing to obtain a nano embedding emulsion; adding citric acid, cane sugar and sodium ascorbate into purified water, adding the nano embedding emulsion, and uniformly stirring to obtain a concentrated solution; and diluting the concentrated solution and adjusting the pH value to obtain the fat-soluble component nano-emulsion. The fat-soluble component nano-emulsion provided by the invention has good safety; the product can be easily absorbed and utilized by a human body, and is convenient for people to quickly supplement vitamin A and vitamin D3 required by the body.
Owner:HEILONGJIANG RENHETANG PHARM CO LTD

Process for making a vegetable fat composition with an increased amount of sn2 positioned palmitic acid

The invention relates to the production of a triglyceride with Palmitic acid (P) in the middle position (XPX). A first transesterification process is used to produce a vegetable fat composition rich in palmitic acid and said intermediate composition is then further processed to produce triglycerides having a high proportion of its palmitic acid in the middle position.
Owner:AAK AB(PUBL)

Preparation method of N-palmitoyl-O-phosphorylcholine serine and deuterated substance thereof

PendingCN121426833APhosphorus organic compoundsPhosphoric Acid EstersSerine methyl ester
The invention belongs to the technical field of organic synthesis, and relates to a preparation method of N-palmitoyl-O-phosphorylcholine serine and a deuterated substance thereof. The N-palmitoyl-O-phosphorylcholine serine and the deuterated substance thereof are obtained by taking L-serine methyl ester hydrochloride and palmitic acid as raw materials through amidation reaction, phosphate esterification reaction, quaternization reaction, oxidation reaction, reduction reaction and the like. The invention provides an approach for industrial production of the N-palmitoyl-O-phosphorylcholine serine and the deuterated substance thereof, and is very important for standardization of the detection method of the N-palmitoyl-O-phosphorylcholine serine.
Owner:XIAN RUIPUYUAN BIOTECHNOLOGY CO LTD

Generalized pustular psoriasis diagnostic marker based on metabonomics and application thereof

The invention discloses a generalized pustular psoriasis diagnosis marker based on metabonomics and application of the generalized pustular psoriasis diagnosis marker. The diagnostic marker is prepared from one or more of the following 35 compounds: pyruvic acid, alpha-ketoisovaleric acid, 2-hydroxybutyric acid, 3-hydroxybutyric acid, methane thiophosphoric acid, proline, uracil, tranexamic acid, 4-aminobutyric acid, threonine, scopoletin, dodecanol, N-methyl-L-leucine, L-cysteine-glycine and L-kynurenine. The feed additive is prepared from the following raw materials: 3-hydroxybenzoic acid, allantoin, delta-tocopherol, xylofuranose, glucose-1-phosphoric acid, pyrophosphate, taurine, L-asparagine, phthalic acid, 4-(dimethylamino) azobenzene, 5-tert-butyl-1h-indole-2, 3-dione, quinic acid, glucose, histidine, lysine, palmitic acid, 7-methylguanine, oleic acid and whale acid. The marker can be used for accurately distinguishing patients with generalized pustular psoriasis from healthy people.
Owner:SHANGHAI DERMATOLOGY HOSPITAL

Phytogenic additive and application thereof in promoting growth and combating coccidiosis and / or necrotic enteritis

PCT designated stageWO2026117596A1Digestive systemAnimal feeding stuffProtozoaDisease
The present disclosure provides a method of reducing, preventing or treating an intestinal infection, preventing or treating a disease associated with protozoan parasite of the genus Eimeria, inhibiting an oocyst sporulation of a protozoan parasite or preventing a sporozoite invasion or reproduction, preventing or treating coccidiosis, promoting growth performance, controlling, treating and / or preventing necrotic enteritis in a subject, comprising administering to the subject an effective amount of a composition comprising a Crassocephalum rabens (CR), a bioactive extract thereof (CRE), an active ingredient(s) contained in a CR (CR_API) or CRE (CRE_API), a combination of two or more of a CR, a CRE, a CR_API and a CRE_API, or one or more of a-linolenic acid, citric acid, lactic acid, mannitol, palmitic acid, aspartic acid and 1-monomyristin.
Owner:ACAD SINICA +2

Method for producing insect pheromone precursor substance in soybean

The invention relates to a plant genetic engineering technology, in particular to a method for producing insect pheromone precursor substances in soybeans. Specifically, transgenic soybeans for expressing exogenous calyx flower plant thiolipase and insect desaturase are obtained through a genetic engineering technology, the transgenic soybeans can synthesize insect pheromone precursor substance cis-11-hexadecenoic acid, and therefore the biological efficiency and feasibility of plant factory pheromone production are proved. Furthermore, as the soybean is used as an oil crop with high acre yield, the soybean naturally contains high-content palmitic acid (C16: 0), the acre yield of the insect pheromone precursor substance cis-11-hexadecenoic acid is predicted to be far higher than that of other plants, and the plant is an ideal biological factory for mass production of the insect pheromone precursor substance cis-11-hexadecenoic acid.
Owner:XIANGHU LABORATORY

Method for compounding lithium oxide collecting agent in low-temperature environment

PendingCN121945307Alowering the freezing pointlow viscosityFlotationLithium oxideMineral flotation
The invention relates to the technical field of mineral flotation, and discloses a method for compounding a lithium oxide collecting agent in a low-temperature environment, and the lithium collecting agent comprises the following compounding raw materials in percentage by mass: 15-25% of palmitic acid soap; 10%-20% of sulfonated petroleum; 5% to 10% of iso-tridecanol polyoxyethylene ether; 8%-15% of fatty alcohol-polyoxyethylene ether; 3%-8% of polyoxyethylene ether sodium sulfonate; 5%-10% of dipropylene glycol monomethyl ether; 8%-15% of sodium carbonate; 2%-5% of sodium hydroxide; 0.5%-2.0% of sodium fluoride; 0.5%-2.0% of aluminum sulfate; 1%-4% of tannic acid; a synergistic surfactant system is formed by constructing palmitic soap and sulfonated petroleum as a main collecting frame and compounding isomeric alcohol ether, fatty alcohol-polyoxyethylene ether and polyoxyethylene ether sodium sulfonate, dipropylene glycol monomethyl ether is introduced as a low-temperature mutual solvent, and the low-temperature mutual solvent is used for collecting the high-temperature-resistant oil-displacing agent for the oil-displacing oil-displacing agent for the oil-displacing oil-displacing oil-displacing oil-displacing oil-displacing oil-displacing oil-displacing oil. The freezing point and viscosity of a collecting agent system are greatly reduced, the liquidity, uniformity and dispersion stability of the collecting agent are still kept when the collecting agent is used in the low-temperature environment of 0-15 DEG C, and the failure problem caused by low-temperature solidification or layering is fundamentally avoided.
Owner:YICHUN UNIVERSITY

A polymethyl methacrylate composition and a method for producing the same

This invention provides a high-gloss black, high-heat-resistant, and easily moldable polymethyl methacrylate (PMMA) composition and its preparation method. The composition comprises the following components in parts by weight: 40-75 parts of polymethyl methacrylate (PMMA) resin, 5-20 parts of toughening agent, 5-30 parts of SAN resin, 10-20 parts of heat resistant agent, 0.5-2 parts of release agent, and 1-5 parts of processing aid. This invention adds appropriate amounts of St-AN-MAH type heat resistant agent and MSAN resin, which synergistically improve the heat resistance of the material. Simultaneously, the addition of palmitic acid improves the material's molding properties. The addition of ACR type toughening agent enables the preparation of a PMMA material that combines toughness, high gloss blackness, high heat resistance, and easy molding, expanding the application range of this material and enabling its widespread use in new energy vehicles.
Owner:WANHUA CHEM GRP CO LTD

Sustainable 2-Alkyltetrahydrofuran Fuels for Compression Ignition Engines

The current invention describes a high-throughput catalytic process for the production of diesel fuel from domestic agricultural products, furfuraldehyde and plant fatty acids. In the present process, reacting medium and long chain fatty anhydrides (such as capric, caprylic, lauric and palmitic) with furfuraldehyde by a Perkin condensation produces 2-n-alkenylfurans. In a second step, the 2-n-alkenylfurans are hydrogenated to form 2-n-alkyltetrahydrofurans. Basic fuel property testing (melting point, density, kinematic viscosity, derived cetane number and calorific value) of the 2-n-alkyltetrahydrofurans indicates they are potentially useful as fuels for diesel engines. One mixture composed of 2-octyl- and 2-decyltetrahydrofuran had the best combination of fuel properties including a low melting point (−39° C.), high cetane number (63.1), high flash point (98.2° C.) and low viscosity (2.26 mm2 / sec, 40° C.) which compares favorably with specifications for diesel #2 and biodiesel.
Owner:THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY

Generalized pustular psoriasis diagnostic marker based on metabonomics and application thereof

The invention discloses a generalized pustular psoriasis diagnosis marker based on metabonomics and application of the generalized pustular psoriasis diagnosis marker. The diagnostic marker is prepared from one or more of the following 35 compounds: pyruvic acid, alpha-ketoisovaleric acid, 2-hydroxybutyric acid, 3-hydroxybutyric acid, methane thiophosphoric acid, proline, uracil, tranexamic acid, 4-aminobutyric acid, threonine, scopoletin, dodecanol, N-methyl-L-leucine, L-cysteine-glycine and L-kynurenine. The feed additive is prepared from the following raw materials: 3-hydroxybenzoic acid, allantoin, delta-tocopherol, xylofuranose, glucose-1-phosphoric acid, pyrophosphate, taurine, L-asparagine, phthalic acid, 4-(dimethylamino) azobenzene, 5-tert-butyl-1h-indole-2, 3-dione, quinic acid, glucose, histidine, lysine, palmitic acid, 7-methylguanine, oleic acid and whale acid. The marker can be used for accurately distinguishing patients with generalized pustular psoriasis from healthy people.
Owner:SHANGHAI DERMATOLOGY HOSPITAL

A tobacco extract composition, and a method of preparing and using the same

PendingCN122350385ABiotechnologyFuran
The present application belongs to the technical field of electronic atomization, and particularly relates to a tobacco extract composition, a preparation method and application thereof. The tobacco extract composition comprises methylcyclopentenolone, guaiacol, neophytadiene, cedrene diol, dihydroactinidiolide, maltol, furaneol, palmitic acid, 6-ethyl-5,6-dihydro-2H-pyran-2-one and scopoletin; the range of (methylcyclopentenolone+guaiacol) / neophytadiene is 0.01-2.5 by mass; the guaiacol content is 0.003-0.02 mg / g by dry matter mass; the tobacco roasting aroma is richer, the tobacco roasting sweet note is more obvious, and the tobacco-like feeling is better. The preparation method comprises: extracting tobacco raw materials twice at medium and low temperatures to obtain tobacco flavor substances, extracting the tobacco raw materials at high temperature to obtain smoke flavor substances, and mixing the tobacco flavor substances and the smoke flavor substances at a certain ratio to obtain the tobacco extract composition.
Owner:SHENZHEN SMOORE TECH LTD

Infant nutrition containing hydrolyzed protein, ionized calcium and palmitic acid

The present invention relates to a composition for a formula for infants or young children, the composition comprising a partially hydrolyzed protein, ionized calcium and an oil mixture comprising palmitic acid esterified to a triacylglycerol wherein the palmitic acid is esterified at the sn-2 position of the triacylglycerol, the esterified palmitic acid being in an amount of at least 20% by weight of the total palmitic acid. Furthermore, the present invention relates to an infant formula comprising said composition and the use of said composition or infant formula.
Owner:SOCIETE DES PRODUITS NESTLE SA

Fat powder for reducing the death rate of weaned piglets, and preparation method and application thereof

ActiveCN117958361BOvercome prone energy supply shortagesOvercome problems like diarrheaFood processingAccessory food factorsBiotechnologyTributyrin
The present application relates to a kind of fat powder for reducing weaning piglet dead rate and its preparation method and application, and the composite lipid in the preparation raw material of fat powder includes 1,3-di-oleic acid-2-palmitic acid triglyceride, 24 degrees palm oil, rice bran oil, coconut oil, linseed oil, caprylic triglyceride, capric acid triglyceride, alpha-lauric acid monoglyceride and tributyrin.The present application develops the fat acid composition close to pig milk fat structure, let piglet continue lactation period in weaning period to enable approach mainly with lipid, meet the compound energy demand of fast, medium and slow, avoid falling into energy potential difference;And the specific combination of medium and short chain fatty acids, both can improve the energy efficiency of weaning piglet, also have bacteriostatic disease characteristics, can improve the immunity of piglet, reduce the diarrhea rate.This composite lipid overcomes the problem such as piglet energy deficiency and indigestion caused by single raw material oil due to unsuitable lipid structure, can significantly reduce weaning stress, reduce the diarrhea rate and dead rate.
Owner:HUBEI YOUBATE BIOLOGICAL ENG CO LTD +1

A ductility improver, modified 50# asphalt and a preparation method thereof

PendingCN122255747AImprove ductility valueGood high temperature storage stabilityBuilding insulationsVegetable oilLinoleic acid
This application discloses a ductility enhancer, modified No. 50 asphalt, and a preparation method thereof. The ductility enhancer comprises, by weight, 50 to 70 parts vegetable oil, 20 to 30 parts linoleic acid, 5 to 15 parts palmitic acid, and 0.5 to 2 parts phenolic anti-aging agent. This application can significantly improve the ductility value of No. 50 asphalt at low temperatures without adversely affecting the softening point, penetration, or other high-temperature indicators of No. 50 asphalt. Furthermore, the No. 50 asphalt of this application exhibits good high-temperature storage stability. The ductility enhancer described in this application is easy to prepare and use in production. The formulation components of the additive can be mixed evenly by simple mechanical stirring, and it is easy to disperse evenly into the asphalt without the need for expensive modification equipment and a long development time.
Owner:HAIYUN (HAINAN) MATERIALS TECHNOLOGY CO LTD +1

Application of palmitic acid and preparation thereof in preparation of medicine for preventing and treating acute exacerbation of chronic obstructive pulmonary disease

The invention relates to the technical field of biological medicines, in particular to application of palmitic acid and a preparation thereof in preparation of medicines for preventing and treating acute exacerbation of chronic obstructive pulmonary diseases. The invention provides application of palmitic acid and a preparation thereof in preparation of a medicine for preventing and treating acute exacerbation of chronic obstructive pulmonary disease. Research finds that supplement of palmitic acid in an acute infection period can improve IFITM3 protein expression of alveolar epithelial cells and further promote downstream secretion of TGF beta by up-regulating the expression level of anti-inflammatory cytokines, so that lung tissue inflammation regression and tissue repair are promoted, and the lung function of patients with chronic obstructive pulmonary diseases is improved.
Owner:RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE

Water-in-oil type cosmetics

ActiveJP2026109288AIsostearic acidPolymer science
To provide a water-in-oil cosmetic that offers both excellent usability as a cosmetic product and high stability. [Solution] A water-in-oil cosmetic composition containing 50% by mass or more of water, comprising the following components (A) to (C): (A) dipolyhydroxy fatty acid polyalkylene glycol, (B) sesquiisostearate sorbitan, and (C) oil thickener. Preferably, component (A) is polyethylene glycol dipolyhydroxystearate, component (B) is sorbitan sesquiisostearate, and component (C) is dextrin palmitate.
Owner:NOEVIR CO LTD

Preparation method and application of lactobacillus reuteri and bacillus subtilis exosome for promoting cat hair degradation

The invention discloses a preparation method and application of exosomes sourced from lactobacillus reuteri and bacillus subtilis for promoting cat hair degradation, the exosomes are respectively sourced from lactobacillus reuteri and bacillus subtilis cultured under a specific fatty acid condition, lauric acid (1-8g / L) is added into a lactobacillus reuteri culture medium, palmitic acid (1-8 g / L) is added into a bacillus subtilis culture medium, and secretion of exosomes is promoted by adjusting the metabolic pathway of thalli. The exosome obtained through extraction and mixing has biological activity of promoting degradation of hair protein in cats and accelerating decomposition of hair balls, and experimental results show that the exosome can significantly reduce the formation rate of the hair balls of the cats and the content of hair in excrement and improve the health state. The invention provides a novel microbial source functional component for developing a safe, efficient and drug-residue-free pet hair ball management product, and has a good application prospect and industrialization value.
Owner:CHANGSHA FULEXIN TECHNOLOGY CO LTD

Method for detecting contents of various components in puffball sample and application of method

PendingCN121208191AComponent separationMedicinal herbsHaplosporangium
The invention discloses a method for detecting the content of various components in a puffball sample and application of the method, and the method comprises the following steps: taking puffball sample powder, adding an extraction solvent for extraction, and preparing to obtain a test solution; taking alpha-linolenic acid, linoleic acid, palmitic acid, oleic acid, stearic acid and ergosterol reference substances, and adding a solvent to prepare a mixed reference substance solution; respectively injecting the mixed reference substance solution and the test solution into an ultra-high performance liquid chromatograph for detection, and comparing the maps of the reference substance solution and the test solution; and making a regression equation by using the sample size Ln value and the peak area Ln value of each component, and calculating the content of the components in the puffball sample. According to the quality detection method for the puffball sample, the contents of the six components can be simultaneously determined, the operation is simple, the accuracy is high, the recovery rate is reliable, the detection efficiency is high, and a basis is provided for standardizing the market of puffball medicinal materials and preparations and reasonably developing the puffball medicinal materials and preparations.
Owner:JIANGYIN TIANJIANG PHARMA

Dual-mode cooperative detection method for unsaturated fatty acid in Baijiu

The invention discloses a dual-mode cooperative detection method for unsaturated fatty acid in Baijiu, and relates to the technical field of food detection. According to the method, aiming at the characteristic of a high alcohol ester matrix of the white spirit and the detection pain point that unsaturated fatty acid is easy to oxidize and large in content span, selective enrichment and matrix purification are performed on a white spirit sample through a silanization modified C18 solid-phase extraction small column, and then low-temperature anti-oxidation derivatization is completed through matching of a composite derivatization reagent and an anti-oxidation system. Then, the palmitic acid, the oleic acid and the linoleic acid are quantified by adopting a gas chromatography-mass spectrometry method, meanwhile, the alpha-linolenic acid is directly detected by adopting a high performance liquid chromatography-quadrupole time-of-flight mass spectrometry method, and finally, results are calibrated and output by combining an internal standard method and an external standard method. According to the method, efficient purification of the Baijiu matrix is achieved, the oxidation loss rate of alpha-linolenic acid is controlled within 3%, high-precision quantification of constant components and high-sensitivity detection of trace components can be synchronously achieved, the method is suitable for detection of full-flavor and full-alcoholic-degree Baijiu, stability and universality are excellent, and reliable technical support is provided for Baijiu quality evaluation.
Owner:JING BRAND

Isobutyrylaminothiazolyl resorcinyl dipalmitate, its preparation process and application

PendingCN122355974AThiazoleWhitening Agents
The application discloses isobutyryl amino thiazyl resorcinol dipalmitate and a preparation method and application thereof. The compound is successfully prepared by performing an acylation reaction on isobutyryl amino thiazyl resorcinol and palmitic acid. Experiments prove that, compared with the prior art, the compound not only retains excellent whitening efficacy, but also exhibits extremely low cytotoxicity and significant soothing efficacy. The compound has whitening, soothing and high safety, overcomes the defect that traditional whitening agents are strong in irritation, and can be directly applied to cosmetics or skin external drugs, and has extremely high industrial value.
Owner:GUANGDONG DINGCHUN BIOMEDICAL TECHNOLOGY CO LTD

Lipotoxic medium

The invention provides a culture medium for culturing heart tissue, a method for inducing diabetic cardiomyopathy disease phenotype in heart tissue, diseased heart tissue and a kit. An exemplary culture medium for culturing cardiac tissue comprises 100 to 300 M of palmitic acid / salt / ester, 100 to 300 M of oleic acid / salt / ester, and 0.5 to 15 nM of endothelin-1.
Owner:VARO HEALTH CO LTD

Meat substitute product

The present invention relates to a meat substitute product comprising a texturized protein ingredient and an emulsion that is comprising a binding agent. a liquid oil. water and a powdered vegetable fat having that is a randomly interesterified and is having a fatty acid moiety comprising a combined content of palmitic acid (C16) and stearic acid (C18) in a range of from 40 to 75 wt. % and a content of lauric acid (C12) in an amount of less than 5 wt. % on total weight of the fatty acid moiety. and wherein the emulsion is present in an amount of from 20 to 50 wt. %. from 25 to 45 wt. %, or from 30 to 40 wt. % on total weight of the meat substitute product. It further relates to the use of the emulsion to improve the fat binding ability in the preparation of a meat substitute product.
Owner:CARGILL INC

Generalized pustular psoriasis diagnostic marker based on metabonomics and application thereof

The invention discloses a generalized pustular psoriasis diagnosis marker based on metabonomics and application of the generalized pustular psoriasis diagnosis marker. The diagnostic marker is prepared from one or more of the following 35 compounds: pyruvic acid, alpha-ketoisovaleric acid, 2-hydroxybutyric acid, 3-hydroxybutyric acid, methane thiophosphoric acid, proline, uracil, tranexamic acid, 4-aminobutyric acid, threonine, scopoletin, dodecanol, N-methyl-L-leucine, L-cysteine-glycine and L-kynurenine. The feed additive is prepared from the following raw materials: 3-hydroxybenzoic acid, allantoin, delta-tocopherol, xylofuranose, glucose-1-phosphoric acid, pyrophosphate, taurine, L-asparagine, phthalic acid, 4-(dimethylamino) azobenzene, 5-tert-butyl-1h-indole-2, 3-dione, quinic acid, glucose, histidine, lysine, palmitic acid, 7-methylguanine, oleic acid and whale acid. The marker can be used for accurately distinguishing patients with generalized pustular psoriasis from healthy people.
Owner:SHANGHAI DERMATOLOGY HOSPITAL

Ascorbyl palmitate nanoliposome capable of inducing tumor cell oncosis, and preparation method and application thereof

The application relates to the field of biological medicine, and discloses ascorbyl palmitate nanoliposomes capable of inducing tumor cell oncosis, a preparation method and application thereof. The nanoliposomes are constructed by inserting ascorbyl palmitate as a lipid component into a phospholipid bilayer, and are prepared by a film dispersion method from lecithin, cholesterol, pegylated phospholipid and ascorbyl palmitate. The average particle size of the nanoliposomes is 80-150 nm, the encapsulation rate is high, and the stability is good. The nanoliposomes can be administered through a tail vein, utilize the specific hydrolysis of matrix metalloproteinase MMP-2 which is highly expressed by tumor cells to hydrolyze ascorbyl palmitate, release palmitic acid and ascorbic acid, thereby inducing Caspase-independent oncosis of tumor cells, effectively overcoming apoptosis-related drug resistance, and reversing a tumor immunosuppressive microenvironment. The nanoliposomes avoid the cumulative toxicity of metal-type inducers, and provide a new safe and effective option for reversing chemotherapy resistance.
Owner:HENAN UNIV OF CHINESE MEDICINE

Application of SAFit2 in preparation of reagent for improving pancreas islet dysfunction

The invention relates to the technical field of biology, in particular to application of SAFit2 in preparation of a reagent for improving pancreas islet dysfunction. The invention discovers that SAFit2 has a remarkable improvement effect on insulin secretion dysfunction in a high-glucose and high-fat induced islet injury model. Experiments show that in a high glucose (33 mM) combined palmitic acid (500 [mu] M) injury model, the SAFit2 can significantly improve the insulin secretion function of the pancreas islet. Specifically, the SAFit2 is pretreated, the glucose stimulated insulin secretion (GSIS) index of the pancreas islet and the intracellular insulin content are remarkably increased, insulin secretion under high glucose stimulation is promoted, and the SAFit2 is proved to have the effect of promoting the insulin secretion function of the pancreas islet beta cells.
Owner:TIANJIN FIRST CENT HOSPITAL

A fatty acid photodecarboxylase mutant, and a preparation method and application thereof

This application discloses a fatty acid photodecarboxylase mutant, its preparation method, and its applications, relating to the field of protein engineering technology. The amino acid sequence of the fatty acid photodecarboxylase mutant of this application comprises a sequence obtained by mutating the 624th amino acid residue site in the sequence shown in SEQ ID NO.1, wherein the mutation type at the 624th amino acid residue site is selected from any one of A624C, A624N, A624Q, and A624S. Compared with the wild type, the preferred mutant of this application exhibits 2-fold and 1.3-fold increased enzyme activity and blue light tolerance, respectively. It achieves a conversion rate of over 90% for the long-chain fatty acid palmitic acid within 8 hours at 30°C, significantly enhancing the enzyme's stability and catalytic efficiency under blue light irradiation. This helps overcome the bottleneck of photoinactivation caused by blue light in the industrial application of fatty acid photodecarboxylase, and has excellent application prospects in biofuel synthesis and green chemistry.
Owner:SOUTH CHINA UNIV OF TECH