154 results about "Valeric acid" patented technology

The invention discloses a pure bio-based polyhydroxyalkanoate adhesive as well as preparation and application thereof, and belongs to the technical field of degradable adhesives. According to the adhesive, polyhydroxybutyrate valerate or polyhydroxybutyrate hexanoate is used as a matrix, and the acid value reaches 2-15 mg KOH / g through molten end group activation; a reactive emulsifier with a hydrophilic-lipophilic balance value of 9-12 is introduced into a water phase, and the stable aqueous dispersion is prepared through phase inversion high-shear emulsification. The Z-average particle size of the dispersion is 0.12-0.30 [mu] m, and the content of the free surfactant is not higher than 30wt%. After the tackifying resin, the plasticizer and the vegetable wax are compounded, the bio-based carbon content of the obtained adhesive is not lower than 95%, and the volatile organic compound content is not higher than 100 mg / kg. The paper / paper heat sealing strength of the adhesive is not lower than 7.0 N / 15mm, the 180-degree peel strength is not lower than 7.5 N / 25mm, and the adhesive can pass repulping evaluation.

The invention discloses a composite medical suture and a preparation method thereof, and belongs to the field of biomedicine. In order to solve the problems that an existing medical suture is poor in antibacterial effect and biological safety, the composite medical suture comprises a core layer, a degradation regulation and control layer, a slow release layer and an antibacterial layer which are sequentially arranged from inside to outside; the core layer is prepared from a blend fiber of poly (hydroxybutyrate-hydroxyvalerate) and polycaprolactone-co-polyglycolide; the degradation regulation and control layer comprises a mixture of at least two kinds of polyethylene glycol with different molecular weights; the slow release layer comprises quaternary ammonium salt loaded graphene oxide nanofibers; the antibacterial layer comprises titanium dioxide loaded with silver nanoparticles. Through the synergistic effect of the four layers, the comprehensive optimization of mechanical properties, degradation rate, drug sustained release and antibacterial function is realized; the purposes of improving the slow-release antibacterial performance, reducing damage to the human body, reducing inflammation and the like are achieved, and the antibacterial and degradation effects meet the recovery requirements.

The invention belongs to the technical field of separation of drug intermediates, and particularly relates to a control method for a process impurity 2-ethyl valeric acid (EP-B) in preparation of valproic acid or sodium valproate by a diethyl malonate method. According to the method disclosed by the invention, the content of 2-ethyl-2-propylmalonic acid process impurities in dipropylmalonic acid is controlled, so that the content of 2-ethylvaleric acid (EP-B) which is a process impurity in valproic acid or sodium valproate is accurately controlled; adding a polar solvent into the dipropylmalonic acid crude product, heating, pulping for a certain time, cooling, filtering and drying to obtain a high-purity dipropylmalonic acid refined product; high-purity valproic acid (RRT is equal to 1.00) is prepared through decarboxylation of the dipropyl malonic acid fine product, and the purity is 99.779%; 0.020% of 2-ethyl valeric acid (RRT is equal to 0.90); and valeric acid (RRT = 0.77), 0.039%. The valproic acid product quality meets the requirements of European Pharmacopoeia. According to the method, the problems of quality control and process evaluation of valproic acid or sodium valproate prepared by a diethyl malonate method are solved.

The invention relates to the field of bio-based composite materials, and discloses a bioplastic-based coupling agent, a modified bamboo fiber, a composite material and a preparation method and application of the bioplastic-based coupling agent and the modified bamboo fiber. The coupling agent is a product obtained by modifying polyhydroxybutyrate valerate and a grafting monomer, and the grafting monomer is at least one of maleic anhydride, acrylic acid or itaconic anhydride. The delignification bamboo powder is modified with the coupling agent, and the modified bamboo fiber, polyhydroxybutyrate-hydroxyvalerate, an initiator and an auxiliary agent are subjected to melt blending to obtain the composite material. The tensile strength and the bending strength of the composite material are respectively improved by 175% and 117%, and the crystallization ability and the thermal stability are also synchronously improved. According to the invention, the unification of high strength, thermal stability and excellent interfacial compatibility is realized while the degradability of the system is maintained, and the composite material has a good green composite material application prospect.

A method of improving flavor of a combination of a composition for increasing circulating ketone levels is disclosed. A composition containing (D)-β-hydroxybutyric acid (D-BHB), (D)-β-hydroxyvaleric acid (D-BHV), and (D)-1,3 butanediol (D-1,3BD) is disclosed. Exemplary compositions may be incorporated into food, supplement, and beverage products.

The invention relates to the technical field of environment-friendly materials, and discloses an environment-friendly plastic bag which is of a three-layer composite structure composed of the following raw materials in parts by weight: an outer layer, 60-80 parts of polylactic acid, 40-60 parts of poly (adipic acid) or butylene terephthalate with a thickness ratio of 40%, and a middle layer, 75-90 parts of modified cassava starch, 25-35 parts of polyvinyl alcohol and 3-8 parts of a citrate cross-linking agent with a thickness ratio of 30%. The inner layer comprises 80-95 parts of polyhydroxybutyrate valerate and 15-25 parts of surface treatment calcium carbonate, the thickness ratio of the inner layer is 30%, the three layers are integrally formed through a co-extrusion film blowing process, and a micron-sized groove array is arranged on the surface of the outer layer. The outer layer adopts the blend of polylactic acid and dibutyl phthalate, the brittleness of polylactic acid is made up by utilizing the flexibility of dibutyl phthalate, and meanwhile, the use amount of pure polylactic acid is reduced, so that the cost is reduced by 40% compared with that of a pure polylactic acid bag; and 15 wt% of stearic acid is added into the inner layer polyhydroxybutyrate valerate to treat calcium carbonate, so that the performance is ensured, and the cost is controlled at the same time.

The invention discloses Kluyveromyces marxianus KUST3801 and application thereof in relieving constipation, and the preservation number of the Kluyveromyces marxianus KUST3801 is CGMCC (China General Microbiological Culture Collection Center) NO.32767. The Kluyveromyces marxianus strain is classified and named as Kluyveromyces marxianus, and the Kluyveromyces marxianus strain is named as Kluyveromyces marxianus. The sequence of the 16SrRNA is as shown in SEQ ID NO. 1; the composition is used for improving constipation symptoms. After the kluyveromyces marxianus KUST3801 is applied, the excrement water content and the small intestine propulsion rate of a mouse with ICR constipation induced by loperamide hydrochloride are remarkably improved, and the defecation frequency and the defecation number within the same time are remarkably increased; intestinal mucosa tissues of constipation mice can be protected, and intestinal mucosa injury is relieved; the concentration of SP and MTL is obviously improved, and the concentration of VIP is reduced; iL-6 concentration is reversed, and inflammatory response is relieved; the concentrations of acetic acid, butyric acid, isobutyric acid and isovaleric acid in the short-chain fatty acid are obviously higher than those of mice with constipation, and the composition has a relatively strong effect of relieving constipation symptoms.

The invention relates to the technical field of comprehensive treatment of agricultural pests, and particularly provides a bactrocera cucurbitae double-trapping type attractant based on optimal matching of host and intestinal bacteria volatile matters and application of the bactrocera cucurbitae double-trapping type attractant. The attractant comprises an active component and a synergistic component, the active component is derived from balsam pear and towel gourd volatile matters and bactrocera cucurbitae intestinal bacterial metabolites, and comprises 2-methyl ethyl valerate, propyl hexanoate, ethyl hexadienoate, heptanal, benzyl alcohol, 3-methyl acetic acid-1-butanol, indole and 1-undecanol; and the synergistic component is myzobenzoic ketone. Active components are quickly released in the early stage of application, so that the attraction efficiency is remarkably improved; the synergistic component prolongs the trapping lasting period through the slow release effect, and the long-term trapping effect is ensured. All the components of the attractant provided by the invention are biological sources or environment-friendly chemical substances, the attractant meets the requirement of green prevention and control, can efficiently attract male and female adults at the same time, makes up the limitation that a traditional sex attractant only induces male adults or a food attractant only induces female adults, and is beneficial to more comprehensive control of population quantity.

The present invention relates to a composition comprising at least one mixture of organic peroxides containing a first organic peroxide of formula (I) and a second organic peroxide, n-butyl-4,4-di(tert-butylperoxy)-valerate. The invention also relates to the use of said composition for crosslinking at least one crosslinkable polymer.

The invention discloses a compound with tyrosinase inhibitory activity and application of the compound in preparation of whitening products, and belongs to the technical field of medicinal chemistry. The compound is 5-(4-hydroxyphenyl)-3-O-glucosyl valeric acid, and is a novel compound. The compound can significantly inhibit the activity of tyrosinase, has the ability of blocking tyrosinase from catalyzing tyrosine to be converted into melanin precursor substances, and directly inhibits the generation of melanin, thereby showing better application prospects and values in skin whitening or skin diseases.

The invention discloses Leishan fish sauce sour essence as well as a preparation method and application thereof. The leishan fish sauce acid essence is prepared from ethyl acetate, absolute ethyl alcohol, ethyl isovalerate, ethyl hexanoate, isoamyl alcohol, furfuryl alcohol, ethyl lactate, ethyl caprylate, acetic acid, diethyl succinate, methyl salicylate, ethyl benzoate, ethyl laurate, hexanoic acid, phenethyl alcohol, 4-methyl guaiacol, ethyl myristate, ethyl palmitate, ethyl oleate, capsicum oleoresin, ethyl phenylacetate and ginger oil. And lactic acid, glycerol triacetate, ocimene, ethyl isovalerate, ethyl butyrate, anethole and phenylacetaldehyde. The Leishan fish sauce sour essence disclosed by the invention is soft and harmonious in overall fragrance, natural and vivid, still has stable flavor characteristics at high temperature, can make up the problem of flavor deficiency in sour soup products, realizes accurate reproduction and controllable release of composite fragrance, improves the standardization level of products, and effectively improves the preference degree of consumers.

A method of improving flavor of a combination of a composition for increasing circulating ketone levels is disclosed. A composition containing (D)-β-hydroxybutyric acid (D-BHB), (D)-β-hydroxyvaleric acid (D-BHV), and (D)-1,3 butanediol (D-1,3BD) is disclosed. Exemplary compositions may be incorporated into food, supplement, and beverage products.

A full continuous-flow preparation method of (+)-biotin, including: subjecting a cyclic anhydride and a chiral biphenyl propylene glycol to asymmetric ring-opening reaction to produce a first intermediate, which undergoes selective reduction with a borohydride and cyclization with an inorganic mineral acid to produce (3aS, 6aR)-lactone; subjecting the (3aS, 6aR)-lactone and a sulfenylating reagent to sulfenylation to produce (3aS, 6aR)-thiolactone, which undergoes Fukuyama coupling with a zinc reagent in the presence of a palladium catalyst and elimination reaction in the presence of an inorganic mineral acid to produce an alkenyl valerate compound; subjecting the alkenyl valerate compound to reduction in the presence of a Pd / C catalyst to produce a valerate ester, which undergoes hydrolysis to produce a valeric acid salt; and subjecting the valeric acid salt to debenzylation in the presence of an inorganic mineral acid to produce the target product (+)-biotin.

The present application relates to the field of biotechnology, in particular to a kind of complex probiotic bacteria capable of synergistic metabolism pectin polysaccharide and application thereof, the complex bacterial agent includes plant lactobacillus FMBL L23180CLL and rhamnose lactobacillus FMBL L23121YWT, preservation number is CCTCC NO:M 20241793 and CCTCC NO:M 20241794 respectively;Can be realized in the medium of pectin as carbon source only rapid proliferation, high-efficiency metabolism pectin polysaccharide, promote the growth of strain, biomass is significantly improved, and probiotic index is also significantly improved;In the process of co-culture, a large amount of short-chain fatty acid is produced, and the content of acetic acid and valeric acid produced at the end of fermentation is the highest, more than 90% of total fermentation product, can be used for preparing microcapsule, complex probiotic bacterial agent, fermented milk, fruit and vegetable beverage, plant milk, probiotic milk tablet and the like, and has wide application prospect.

The invention discloses a colorectal cancer diagnostic marker group based on expiration volatile organic compounds and application of the colorectal cancer diagnostic marker group. The colorectal cancer diagnostic marker group consists of six expiration volatile organic compounds, namely furfural, 2-methyl butane, valeric acid, methyl allyl sulfide, hexane and octanal. According to the method, expiration samples of 182 subjects are analyzed through TD-GC-MS / MS, machine learning is combined, the six expiration volatile organic compounds are screened out, the diagnosis AUC of the combination in a verification queue reaches 0.907, the accuracy rate is 0.806, and the combination is superior to a serum marker combination (AUC = 0.861). The invention further provides the BRS and a colorectal cancer noninvasive diagnosis and risk stratification system, and the BRS and the colorectal cancer noninvasive diagnosis and risk stratification system are used for achieving efficient prediction and risk stratification of the colorectal cancer. Compared with a traditional risk scoring model depending on clinical variables such as age, family history and lifestyle, the BRS provides unique metabonomics information, and the prediction accuracy is remarkably improved.

The invention relates to a preparation method of peppermint essence, which solves the problems of quick volatilization and poor durability of the traditional peppermint essence by optimizing the combination of essence components and a slow-release carrier by adopting a multi-layer microcapsule slow-release technology and a nanocapsule technology. According to the method, essence components such as menthol, menthone and leaf isovalerate are mixed with at least two layers of microcapsules, the outer layer microcapsules slowly release fragrance, the inner layer microcapsules quickly release fragrance, and it is ensured that the fragrance is kept for a long time in the using process. Meanwhile, the essence is uniformly dispersed in different carrier systems through ultrasonic-assisted emulsification by adopting a nanocapsule technology, so that the stability and dispersity of the essence are improved. In addition, the temperature-responsive and pH-responsive polymer materials are introduced, so that the release rate of the essence can be adjusted according to the external environment, and the adaptability of the essence is further enhanced.

The invention discloses a blood perfusion adsorbent for adsorbing endotoxin by double acting forces as well as a preparation method and application of the blood perfusion adsorbent. The adsorbent (PS-DVB (at) p (CD-His)) is subjected to raft polymerization through 4-cyano-4-(thiobenzoic acid) valeric acid grafted on the surface of PS-DVB to generate a glycidyl methacrylate brush polymer, and is combined with an L-histidine modified cyclodextrin functional molecule; the positive charges of histidine groups and the hydrophobic cavities of the cyclodextrin are used for realizing electrostatic and hydrophobic interaction to synergistically and efficiently adsorb endotoxin. The materials of the blood perfusion adsorbent are easy to obtain, the cost is low, the blood perfusion adsorbent has good blood compatibility and endotoxin adsorption performance, the development of the adsorbent is beneficial to in-vitro blood perfusion treatment of septicopyemia patients, and the clinical treatment cost is reduced.

The application provides application of a walnut green peel extract in preparation of rumen fermentation regulation products, and belongs to the technical field of feed preparation.The walnut green peel extract in the application is prepared by extracting walnut green peel with an extraction solvent, concentrating the extract into a paste under reduced pressure, and drying and crushing the paste at low temperature.Adding 0.5% of the walnut green peel extract to a high-concentrate sheep feed has the effects of preventing the decrease of rumen pH, increasing the activities of rumen cellulose-degrading enzymes and the acetic acid level, and significantly reducing the concentrations of propionic acid and valeric acid.The experimental results show that, after the rumen fermentation regulation product in the application is used, the average rumen pH of sheep in a whole day is increased by 0.24, the filter paper enzyme activity is increased by 73%, the cellobiase activity is increased by 66%, the acetic acid is increased by 29%, and the propionic acid and valeric acid are respectively reduced by 28% and 43%, which indicates that the product in the application can play a high-efficiency rumen fermentation regulation role in the high-concentrate feeding process of rumen animals.

The invention discloses a method for determining the content of seven genotoxic impurities in epichlorohydrin through gas chromatography-mass spectrometry, and belongs to the technical field of pharmaceutical analysis. According to the method, a quartz capillary chromatographic column taking polyethylene glycol as a stationary phase is adopted, split-flow sample injection is performed, and the genotoxic impurities in an epoxy chloropropane sample are detected by using a gas chromatography-mass spectrometry method; the genetic toxicity impurities are glycidyl, 1, 3-dichloro-2-propyl alcohol, 2, 3-dichloro-1-propyl alcohol, 3-chloro-1, 2-propylene glycol, 2-chloro-1, 3-propylene glycol, 2-chloro-2-propylene-1-alcohol, and 1, 2, 3-trichloropropane. The invention further discloses a preparation method of the compound. According to the present invention, the seven genotoxic impurities in the epoxy chloropropane can be rapidly, effectively, accurately and reliably separated and detected, and the genotoxic impurities can be controlled within the low detection range through the mass spectrometer, such that the quality of the epoxy chloropropane can be easily controlled, the product quality of the hexyl aminolevulinate hydrochloride can be easily improved, and the medication safety of the patient can be easily improved.

The application provides a flavor composition for electronic cigarettes, electronic cigarette liquid and a preparation method thereof. The flavor composition for electronic cigarettes comprises 0.1-0.4 parts of ethyl isovalerate, 2.0-5.0 parts of isoamyl acetate, 0.1-0.6 parts of ethyl butyrate, 0.4-1.6 parts of ethyl acetate, 0.1-0.6 parts of propyl acetate, 0.1-0.6 parts of myric aldehyde, 0.05-0.3 parts of malic acid liquid and 0.02-0.1 parts of acetic acid liquid. By adjusting the ratio of the flavor composition, the application makes the flavor composition have strawberry flavor, can restore the pure fruit pulp aroma of strawberries, has high restoration degree of strawberry flavor, long aftertaste and good stability after high-temperature and high-humidity baking, and can be applied to electronic cigarette liquid, thereby improving the experience of users using electronic cigarettes.

The present application belongs to the technical field of fermented fruit juice, and particularly relates to a method for preparing high-quality probiotic fermented strawberry juice based on magnetic field assistance. The present application first uses Lactobacillus plantarum CTCF-LP-1 to perform static fermentation on the strawberry juice to be fermented in a fermentation device for more than 24 hours, and then places the fermentation device in a static magnetic field. The static magnetic field reduces the generation of organic acid components by Lactobacillus plantarum during the fermentation process of the strawberry juice, reduces the acidity, and improves the fermentation quality of the strawberry juice. The magnetic field strength of the static magnetic field is 1.0-2.5 mT, and the fermentation time in the static magnetic field is 0.5-1.5 h. After the static fermentation and the magnetic field treatment, the content of malic acid, isocitric acid, glutaconic acid and other organic acid components in the fermented strawberry juice is significantly reduced, while the content of alcohol and ester components such as n-octanol, 2-phenylethanol, methyl benzoate, 3-hexyl hexanoate and butyl valerate is increased, the types of aroma components are more abundant, and the taste and quality of the strawberry juice are significantly improved.

To provide a beer-taste beverage in which a grassy taste is reduced and a light and brisk aftertaste is imparted, and a method for producing the same. In a beer-taste beverage, the problem of the present application can be solved if at least one of the following (A) to (C) is satisfied. (A) The containing concentration of ethyl 2-methylbutanoate is 15 ppb or more; (B) The containing concentration of ethyl 2-methylbutanoate is 45 ppb or more; (C) The containing concentration of diethyl succinate is 520 ppb or more.

Provided is an oral composition in which sourness of chlorogenic acid and quinic acid is suppressed. The oral composition contains the following components (A), (B), and (C): (A) 0.01% by mass or more and 50% by mass or less of chlorogenic acid, (B) quinic acid, and (C) isovaleric acid, wherein the mass ratio [(B) / (A)] between the component (A) and the component (B) is 0.01 or more and 0.1 or less.

The invention relates to the technical field of cigarette perfuming, in particular to a cellulose core wire for cigarette perfuming and a preparation method of the cellulose core wire. The preparation method comprises the following steps: dipping a core wire in an essence solution, taking out the core wire after dipping, and drying to obtain the cellulose core wire for cigarette perfuming, the core yarn is made of pure viscose yarn with the linear density of 110-120 tex, the S twist and the twist degree of 60-110 twists per meter. In the essence solution, essence components comprise isoamyl isovalerate, ethyl butyrate and farnesol, and a solvent is ethanol. According to the preparation method, the stability and uniformity of the incense line in subsequent use are remarkably improved, and the consistency of essence loading and releasing is guaranteed; in addition, the prepared cellulose core wire has excellent performance and good on-machine applicability, and the situation that the cellulose core wire is seriously deformed or broken or the like is not prone to occurring in the process of being implanted into cigarette components.

This invention provides a simple method for evaluating whether or not a peptide binds to isovaleric acid. [Solution] A method for evaluating the binding affinity to isovaleric acid, comprising a preparation step of preparing a fluorescently labeled compound in which a fluorescent group is bonded to the α-carbon atom of isovaleric acid, and a contact step of contacting the fluorescently labeled compound with a peptide fragment of an olfactory receptor.

The present disclosure relates to a body-derived odor removal composition. The composition for removing body-derived odors according to the present disclosure contains dimethylhydroquinone as an active ingredient, and thus has significantly excellent effects of removing body-derived odors, preferably body odors caused by nonenal, isovaleric acid, diacetyl, and the like.

The invention relates to the technical field of tipping paper for cigarettes, in particular to flavoring and flavoring tipping paper and a preparation method thereof.The flavoring and flavoring tipping paper comprises a base material and a gloss oil layer arranged on the base material, and the gloss oil layer is formed by printing composite gloss oil on the base material; the compound gloss oil is prepared from the following components in parts by mass: 3 to 5 parts of 2-nonyl alcohol, 3 to 5 parts of hexyl acetate, 5 to 10 parts of isoamyl butyrate, 10 to 15 parts of isoamyl isovalerate, 5 to 10 parts of leaf alcohol, 7 to 10 parts of leaf acetate, 2 to 5 parts of acetic acid, 2 to 5 parts of diethyl malate, 35 to 63 parts of ethanol, 2 to 8 parts of sweetening agent, 10 to 20 parts of acidulant, 1 to 5 parts of vitamin and 65 to 86 parts of water-based gloss oil. The sour agent, the sweetening agent and the vitamins are further introduced through aroma components of specific types and proportions, the taste level can be enriched, harmful substances in smoke can be neutralized in the cigarette smoking process, and the smoking experience of consumers is improved.

The present invention discloses a composite medical suture and a preparation method thereof, which belong to the field of biomedicine. In view of the problems of poor antibacterial effect and biosafety of existing medical sutures, the present invention provides a composite medical suture, comprising a core layer, a degradation regulating layer, a sustained-release layer and an antibacterial layer arranged in sequence from the inside to the outside; the core layer comprises a blended fiber of polyhydroxybutyrate-valerate copolyester and polycaprolactone-co-glycolide; the degradation regulating layer comprises a mixture of at least two polyethylene glycols of different molecular weights; the sustained-release layer comprises quaternary ammonium salt-loaded graphene oxide nanofibers; the antibacterial layer comprises titanium dioxide loaded with silver nanoparticles. The present invention achieves comprehensive optimization of mechanical properties, degradation rate, drug sustained release and antibacterial function through the synergistic effect between the four layers; achieves the purpose of improving sustained-release antibacterial performance, reducing damage to the human body and reducing the occurrence of inflammation, etc., so that its antibacterial and degradation effects meet recovery requirements.

The invention provides a pet cleaning agent with dual functions of deodorization and softening and a preparation method of the pet cleaning agent, and relates to the technical field of pet supplies. According to the formula prepared by the invention, based on the principles of sterilization inhibition and neutralization degradation, a bactericide, a deodorant and a hair conditioner (a silicone oil conditioner and a cationic conditioner) are compounded to prepare the pet cleaning agent with dual functions of deodorization and softening. The pet hair conditioner can effectively improve the smoothness, bacteriostasis and deodorization performance and durability of pet hair, and can remove odor generated by ammonia gas, methyl mercaptan, isoamylamine, 3-hydroxyisovaleric acid, trimethylamine, 3-mercapto-3-methyl-1-butanol and 3-methylindole on the body surface of a pet.

The present invention relates to a photocatalyst and a preparation method therefor. The photocatalyst according to the present invention comprises titanium dioxide with a bronze crystal phase and an anatase crystal phase so as to have high photoactivity, and thus is suitable for removing odors and toxic gases. In addition, the titanium dioxide included in the photocatalyst, according to the present invention, has a novel crystal phase having a charge separation effect superior to those of other crystal phases, and thus has improved photoactivity. Additionally, the photocatalyst of the present invention has high photoactivity, and thus is suitable for removing odors and toxic gases. In addition, the photocatalyst of the present invention has excellent durability against catalytic poisons formed on the surface of a catalyst during removal of VOCs and toxic gases (acetaldehyde, isovaleraldehyde, isovaleric acid and toluene).