28 results about "Thiolactone" patented technology

The invention discloses an in-situ curable electrolyte, an in-situ curable electrolyte formed by the in-situ curable electrolyte and a battery. The in-situ curable electrolyte comprises an electrolyte and an electrolyte additive, wherein the electrolyte additive comprises a compound A and a compound B, and the compound A is selected from one or more of compounds with a structure as shown in a formula (1); the compound B is selected from one or more of amino-containing compounds; in the formula (1), R3 is a substituent group containing an unsaturated bond. The in-situ curing electrolyte formed by the electrolyte capable of being cured in situ contains a multiple cross-linked network structure formed by interaction of amido and thiolactone, so that the mechanical strength of the gel electrolyte is improved; meanwhile, the gel electrolyte contains disulfide bonds and hydrogen bonds, so that the gel electrolyte is endowed with certain self-repairing capability, and the cycle life of a battery can be prolonged. # imgabs0 #

The application discloses a multifunctional solid-solid phase change material based on thiolactone chemistry and a preparation method and application thereof, and relates to the technical field of high polymer materials.The method comprises the following steps: dissolving double bond functionalized thiolactone and acrylic ester in an organic solvent A, then adding a free radical initiator, and obtaining a polymer PTA through reaction; dissolving the PTA in an organic solvent B, then adding a fatty amine, a fatty acrylic ester and a crosslinking agent, uniformly mixing, and obtaining a mixed solution; and heating the mixed solution to 60-80 DEG C, and reacting for 1-2 hours, so as to obtain the solid-solid phase change material.The solid-solid phase change material prepared by the application exhibits the multifunctionalities of infrared invisibility, reversible anti-fake and shape memory, etc.The integration of these characteristics provides a broad prospect for the development of the next generation of high-performance intelligent materials.

A full continuous-flow preparation method of (+)-biotin, including: subjecting a cyclic anhydride and a chiral biphenyl propylene glycol to asymmetric ring-opening reaction to produce a first intermediate, which undergoes selective reduction with a borohydride and cyclization with an inorganic mineral acid to produce (3aS, 6aR)-lactone; subjecting the (3aS, 6aR)-lactone and a sulfenylating reagent to sulfenylation to produce (3aS, 6aR)-thiolactone, which undergoes Fukuyama coupling with a zinc reagent in the presence of a palladium catalyst and elimination reaction in the presence of an inorganic mineral acid to produce an alkenyl valerate compound; subjecting the alkenyl valerate compound to reduction in the presence of a Pd / C catalyst to produce a valerate ester, which undergoes hydrolysis to produce a valeric acid salt; and subjecting the valeric acid salt to debenzylation in the presence of an inorganic mineral acid to produce the target product (+)-biotin.

The purpose of the present invention is to provide a method for producing a hydroxybiotin derivative and a vinylbiotin derivative with which it is possible to carry out, in a smooth and highly efficient manner, a coupling reaction between a thiolactone derivative and a zinc reagent containing a halogen atom other than an iodine atom by using an inexpensive metal catalyst. The present invention provides a method for producing a hydroxybiotin derivative, the method including a step for bringing a thiolactone derivative represented by formula (1) into contact with a zinc reagent represented by formula (2) in the presence of a copper catalyst and an amine compound, thereby obtaining a hydroxybiotin derivative represented by formula (3).

This invention discloses a method for preparing hydrophobic and oleophobic photovoltaic glass, comprising the following steps: Step 1: Preparing ordinary photovoltaic glass according to conventional photovoltaic glass preparation methods; Step 2: Preparing a hydrophobic and oleophobic modified epoxy resin coating solution, wherein the hydrophobic and oleophobic modified epoxy resin coating solution comprises, by weight, 2-5 parts of thiolactone-terminated fluorinated prepolymer, 15-16 parts of 4,4'-diaminodiphenylmethane, 0.13-0.14 parts of alkaline catalyst, 25-26.5 parts of epoxy resin, and the remainder being tetrahydrofuran solvent; Step 3: Preparing the hydrophobic and oleophobic photovoltaic glass by spraying the hydrophobic and oleophobic modified epoxy resin coating solution obtained in Step 2 onto the surface of the photovoltaic glass obtained in Step 1, and after curing and drying, forming a hydrophobic and oleophobic layer on the surface of the photovoltaic glass, thereby obtaining the hydrophobic and oleophobic photovoltaic glass. The hydrophobic and oleophobic photovoltaic glass provided by this invention achieves improved hydrophobic and oleophobic properties without affecting light transmittance.

A process for preparing preferably degradable copolymers by free radical ring-opening polymerization using thionolactone monomers or thionocarbonate monomers, in the presence of a radical polymerization initiator. Also, the copolymers, which include thioester or thiocarbonate bonds, that are obtained by carrying out the process including the free radical ring-opening polymerization using thionolactone monomers or thionocarbonate monomers.

Nitric oxide precursors for providing nitric oxide are provided. The nitric oxide precursors comprise a reaction product of a thiolactone, a primary amine, and a nitrosating compound. The nitric oxide precursors are capable of decomposing to form nitric oxide.

The present invention relates to a high-toughness self-healing supramolecular polyurethane elastomer based on thiolactone chemistry and a preparation method thereof. A novel diol chain extender with a suspended 2-urea-4[1H]-pyrimidinone (UPy) motif and an imidazole ligand is synthesized by a one-pot two-step "amine-mercapto-acrylate" coupling reaction of thiolactone, which is then introduced into polyurethane, and further cross-linked by metal ions to obtain a supramolecular polyurethane elastomer. UPy quadruple hydrogen bonds and metal-imidazole coordination serve as dynamic crosslinking points and sacrificial bonds, playing a synergistic role in the strengthening and toughening of the elastomer. At the same time, the reversible recombination of hydrogen bonds and coordination bonds and the higher mobility of the side chains give the material the ability to gently repair damage. Compared with single supramolecular systems based on UPy quadruple hydrogen bonds or metal-imidazole coordination, the elastomer has better mechanical properties and shows great application potential in the fields of flexible electronics and wearable devices.

The invention relates to a porous polymer material and a preparation method and application thereof.The preparation method comprises the steps that firstly, a compound containing sulfydryl and thiolactone is designed and synthesized, a mixed solution of the compound, a polar solvent and a surfactant serves as a continuous phase, a non-polar solvent serves as a dispersion phase, oil-in-oil type high-internal-phase emulsion is formed after emulsification, and the porous polymer material is obtained; and reacting with a polyamine compound to obtain the sulfydryl-containing porous polymer material. The prepared porous material can adsorb heavy metal ions in water and can be used in the field of water treatment.

A nitric oxide precursor for providing nitric oxide is provided. The nitric oxide precursor comprises a reaction product of a thiolactone, a primary amine, and a nitrosating compound. The nitric oxide precursor is capable of decomposing to form nitric oxide.

The invention discloses a preparation method and antibacterial application of a cationic polymer rich in guanidyl, and belongs to the field of medical polymer materials. The preparation method of the cationic polymer rich in guanidyl comprises the following steps: dissolving thiolactone acrylamide in a solvent, and adjusting the pH value to be alkaline to obtain a thiolactone acrylamide solution; and adding an amine compound into the thiolactone acrylamide solution, reacting, and dialyzing to obtain the cationic polymer rich in guanidyl, wherein the amine compound is a primary amine compound or a secondary amine compound, and the amine compound contains agmatine sulfate. According to the invention, through molecular design and synthesis condition optimization, and screening of antimicrobial performance, biocompatibility and the like, the guanidyl cationic antibacterial polymer with excellent comprehensive performance of antibacterial effect and safety is finally obtained. The guanidyl cationic polymer shows good broad-spectrum antibacterial activity and biofilm resistance activity.

The present disclosure provides thionolactones (e.g., compounds of Formula II, and tautomers and salts thereof). The thionolactones may be useful as comonomers to copolymerize with other comonomers, e.g., methacrylates (e.g., MMA) to generate copolymers, e.g., random copolymers. The copolymers may be degradable (e.g., backbone degradable). The copolymers may be useful for waste management or biodegradability.

The present invention discloses series of compounds as a new antibiotic for the treatment of a subject with various infections, including infections caused by Neisseria gonorrhoeae. In particular, those compounds comprise α-methylene and α-aminomethyl lactones, lactams, iminolactones, and iminolactams, thiolactones, thionolactones, thiolactams, and thionolactams. Pharmaceutical compositions and methods for treating those infections are within the scope of this invention.

The present invention discloses a hydrophilic skeleton fluorine-containing polymer and its preparation method and application, belonging to the technical field of application-based material preparation. The hydrophilic skeleton fluorine-containing polymer of the present invention has a double hydrophilic structure of the skeleton and the side chain. Its good hydrophilicity enables it to have an excellent fluorine signal in the deep tissue of the organism, satisfying 19 The invention utilizes the characteristic of allyl (2-oxotetrahydrothiophene-3-yl) carbamate having dual reaction sites, introduces fluorine-containing 2-((2,2,2-trifluoroethyl)thio)ethane-1-amine into the system through a ring-opening reaction between an amino group and a thiolactone, obtains a precursor having dual reaction sites of a thiol group and a double bond, initiates photopolymerization with benzoin dimethyl ether, then introduces a carboxyl group at the end through thioglycolic acid, and finally obtains a fluorine-containing polymer with a dual hydrophilic skeleton and side chains through oxidation. The experimental operation is simple and the raw materials are readily available.

The invention relates to the field of synthesis of chiral polymers and chiral small organic molecules, in particular to a preparation method of a racemic 3-substituted-2-ketothiolactone monomer. The invention relates to a method for preparing isotactic thiolactone through kinetic resolution ring-separation polymerization reaction and a method for preparing an optically pure 3-substituted-2-ketothiolactone monomer. A process for preparing optically pure polymers by ring-opening polymerization; the invention relates to a method for preparing optically pure 2-substituted thiohydracrylic acid serving as a drug synthesis intermediate from optically pure 3-substituted-2-ketothiolactone.

The present invention relates to polydithioacetal copolymers, preferably degradable or biodegradable, their manufacture process by radical polymerization, their uses, the use of dithiolactones as precursor co-monomers in radical polymerization, and dithiolactones for the preparation of said copolymer or for carrying out said process. More particularly, the present invention relates to a process for preparing copolymers, preferably degradable or biodegradable, by radical polymerization, notably employing at least one dithiolactone monomer and at least one monomer comprising an ethylenic unsaturation. Figure for the abstract: Fig. 1

A nitric oxide precursor for providing nitric oxide is provided. The nitric oxide precursor comprises a reaction product of a thiolactone, a primary amine, and a nitrosated compound. The nitric oxide precursor is capable of decomposing to form nitric oxide.

A monomer design strategy based on a bridged bicyclic thiolactone that produces stereo-disordered to perfectly stereo-ordered polythioesters is disclosed. The described polythioesters exhibit high crystallinity and full chemical recyclability. Such polymers possess intrinsic tacticity-independent crystallinity and chemical recyclability, tunable tacticities from stereo-disorder to perfect stereoregularity, as well as combined high-performance properties such as high thermal stability and crystallinity, and high mechanical strength, ductility and toughness.

The present application relates to a kind of dual dynamic key crosslinking near-infrared light response liquid crystal elastomer and its preparation method, belong to liquid crystal elastomer technical field.The liquid crystal elastomer is by liquid crystal monomer, dopamine hydrochloride monomer, chain extender and crosslinking agent under the action of triethylamine by Michael addition polymerization, obtain the main chain type liquid crystal polymer containing catechol and thiolactone side group, liquid crystal polymer is by Fe 3+ The liquid crystal elastomer with dynamic crosslinking network formed by catechol coordination interaction.The present application realizes the pre-crosslinking of liquid crystal elastomer by Fe 3+ Catechol coordination interaction realizes the pre-crosslinking of liquid crystal elastomer while introducing photo-thermal effect, and the photo-thermal effect is excellent, and can enhance the mechanical properties of liquid crystal elastomer;Thiolactone side group is fixed by ring-opening crosslinking reaction with di-functional primary amine and the single-domain structure of liquid crystal elastomer, and the programming preparation method is simple and efficient.

Compounds to treat various infections, including infections caused by Clostridioides difficile, particularly the compounds α-methylene and α-aminomethyl lactones, lactams, iminolactones, and iminolactams, thiolactones, thionolactones, thiolactams, and thionolactams; pharmaceutical compositions; and methods for treating those infections.

The present invention belongs to the technical field of acrylic resins, and specifically relates to a high-solid, low-viscosity acrylic resin and its preparation method and application. The present invention uses a segmented polymerization method to prepolymerize an acrylic acid mixture containing acrylic acid, methyl methacrylate, and hydroxyethyl methacrylate, then add an acrylic acid mixture containing a modified prepolymer, acrylic acid, and butyl acrylate and react with a nano-toughening additive, and finally add deionized water for emulsification to obtain a high-solid, low-viscosity acrylic resin; the nano-toughening additive introduces a rigid furan group to improve the toughening ability and wear resistance of nano-silica; thiolactone acrylamide is prepolymerized with N-isopropyl-N-benzyl-2-acrylamide, and the aminolysis ring is reacted with octadecyl acrylate to obtain a modified prepolymer, which introduces a long-chain alkyl side chain group and a benzene ring structure, thereby improving the flexibility and salt spray resistance of the modified prepolymer. When applied to automotive varnish, the anti-scratch performance of the varnish can be improved.

The invention discloses a skin-friendly antibacterial fiber and a preparation method thereof, and relates to the field of fiber fabrics. When the skin-friendly antibacterial fiber is prepared, zinc nitrate and copper nitrate react and then are calcined to prepare copper / zinc oxide nanoparticles, and the copper / zinc oxide nanoparticles are activated by N, N '-carbonyldiimidazole and then react with DL homocysteine thiolactone hydrochloride and 3-dimethylaminopropylamine to prepare modified copper / zinc oxide nanoparticles; the preparation method comprises the following steps: reacting octamethylcyclotetrasiloxane with 3-chloropropylmethyldimethoxysilane, and then reacting with hydroxypropyl silicone oil to prepare polysiloxane; the preparation method comprises the following steps: reacting 1, 3-propylene glycol, dimethyl terephthalate and polytetramethylene ether glycol to prepare pre-polyester; reacting the pre-polyester with polysiloxane to obtain modified polyester; and carrying out melt extrusion, granulation and spinning on the modified polyester and the modified copper / zinc oxide nanoparticles by a twin-screw extruder. The prepared skin-friendly antibacterial fiber has good antibacterial performance and good skin-friendly performance.

The present invention addresses the problem of providing a method for producing a hydroxy biotin derivative and a method for producing a vinyl biotin derivative, whereby a coupling reaction between a thiolactone derivative and a zinc reagent containing a halogen atom other than iodine can be smoothly and efficiently performed using an inexpensive metal catalyst, and provides a method for producing a hydroxy biotin derivative. Comprising a step of bringing a thiolactone derivative represented by formula (1) into contact with a zinc reagent represented by formula (2) to obtain a hydroxybiotin derivative represented by formula (3). # imgabs0 # X-Zn-R3-R4 (2) # imgabs1 #

At least one nanoworm comprises a plurality of alkene units and a plurality of macroCTA polymer units. The macroCTA polymer units include R1 groups from reversible addition-fragmentation chain-transfer agents. In certain aspects, the R1 groups of the macroCTA polymer units are functional groups, such as a carboxylic acid, an alkyne, a pyridine, a dopamine, a thiolactone, a biotin, an azide, a peptide sequence, a sugar sequence, a protease, a glycanase, a polymer, other functional groups, and combinations thereof. In certain aspects, the macroCTA polymer units comprise quaternized amines. In certain aspects, the macroCTA polymer units comprise functionalized quaternized amines, such as an alkyl group, a carboxylic acid, an alkyne, a pyridine, a dopamine, a thiolactone, a biotin, an azide, a peptide sequence, a sugar sequence, a protease, a glycanase, a polymer, other functional groups, and combinations thereof. In certain aspects, the coating comprises the at least one nanoworm.

The invention discloses a preparation method of homocysteine thiolactone hydrochloride, which comprises the following steps: preparing a DL-homocystine crude product, preparing a DL-homocystine refined product, dissolving the DL-homocystine refined product in diluted hydrochloric acid, and carrying out electrolytic reaction by using an electrolytic bath. And collecting catholyte, adding activated carbon into the catholyte for decoloration and filtration, then performing vacuum concentration, cleaning with an ethanol solution, and drying after cleaning to obtain the DL-homocysteine thiolactone hydrochloride. After the homocystine crude product is prepared, the homocystine crude product is refined, so that the appearance chromaticity and purity of a subsequent product can be improved. According to the invention, the preparation process of the cathode material glassy carbon is optimized, so that higher total yield can be obtained when the modified glassy carbon is used as the cathode material.

The present disclosure discloses a novel method for interfacial chain-growth polymerization and an ultra-high molecular weight polymer. The present disclosure pertains to the technical field of preparing an ultra-high molecular weight polymer. The novel method for interfacial chain-growth polymerization comprising steps of: mixing a combined catalyst of an organic base and a hydrogen bond donor, an initiator, a monomer to carry out the interfacial chain-growth polymerization; wherein the monomer is selected from a lactide, a lactone, a thiolactone, a lactam, an acrylate or an olefin; the initiator is one or more selected from the group consisting of alcohol-based substances and thiol-based substances; and the hydrogen bond donor is selected from a structure represented by Formula 1 or a structure represented by Formula 2. The novel method effectively suppresses polymerization side reactions through phase separation of the polymer chains from the solvent, thereby obtaining an ultra-high molecular weight polymer. The poly(thioglycolide) of the ultra-high molecular weight polymer has good thermal and mechanical properties, and excellent barrier property, especially outstanding oxygen barrier property. Also, the poly(thioglycolide) can be recycled by solution depolymerization.

The invention discloses a preparation method of hydrophobic and oleophobic photovoltaic glass. The preparation method comprises the following steps: step 1, preparing common photovoltaic glass according to a conventional photovoltaic glass preparation method; 2, a hydrophobic and oleophobic modified epoxy resin coating solution is prepared, and the hydrophobic and oleophobic modified epoxy resin coating solution is prepared from, by mass, 2 parts to 5 parts of thiolactone end-capped fluorinated prepolymers, 15 parts to 16 parts of 4, 4 '-diaminodiphenylmethane, 0.13 part to 0.14 part of base catalysts, 25 parts to 26.5 parts of epoxy resin and the balance tetrahydrofuran solvents; and step 3, preparing the hydrophobic and oleophobic photovoltaic glass, spraying the hydrophobic and oleophobic modified epoxy resin coating solution prepared in the step 2 on the surface of the photovoltaic glass prepared in the step 1, curing and drying to form a hydrophobic and oleophobic layer on the surface of the photovoltaic glass, and preparing the hydrophobic and oleophobic photovoltaic glass. According to the hydrophobic and oleophobic photovoltaic glass provided by the invention, the hydrophobic and oleophobic performance is improved on the premise that the light transmittance is not influenced.

Nitric oxide precursors for providing nitric oxide are provided. The nitric oxide precursor comprises the reaction product of a thiolactone, a primary amine, and a nitrosation compound. The nitric oxide precursor is capable of decomposing to form nitric oxide.