57 results about "Thiolactone" patented technology

The invention discloses an Hg2+ sensor based on upconversion NaYF4 resonance energy transfer and a detection method of the Hg2+ sensor. The detection method provided by the invention comprises the following steps: an ultrasonic micro-emulsion method is utilized for obtaining the water soluble and monodisperse rare-earth upconversion nano-particles with uniform grain sizes, which are superficially modified with rhodamine thiolactone, namely the Hg2+ sensor based on upconversion NaYF4 resonance energy transfer; in the presence of Hg2+, the rhodamine thiolactone decorated on the surfaces of the nano-particles and Hg2+ are specially combined to be conducted for ring opening, a maximum absorption peak at 555nm stimulated by near-infrared light at 980nm and an emission peak of the NaYF4 nano-particles at 543nm are just overlapped to be conducted for resonance energy transfer, and the fluorescent emission peaks of the NaYF4 nano-particles are quickly quenched, so that the aim of qualitatively and quantitatively detecting Hg2+ can be achieved by detecting the fluorescence intensity. Compared with the traditional detection method, the detection method provided by the invention is small in background interference, strong in signal, low in cost, and has the characteristics of fastness, accuracy, high flexibility and high selectivity.

The invention provides a preparation method of a biotin intermediate impurity with the structural formal shown in a formula (V). Thiolactone and the Grignard reagent are taken as raw materials, and the high-purity intermediate impurity is obtained through addition and hydrolysis. The preparation method is simple and easy and is particularly suitable for preparation in a laboratory.

The invention discloses a medicine for alleviating municipal sewage pipeline blocking and application of the medicine. The medicine is prepared from the following components in percentage by mass: 20-40% of a quorum sensing inhibitor, 30-50% of a surfactant and 20-30% of a solubilizer, wherein the quorum sensing inhibitor consists of the following components mixed in percentage by mass: 40-60% of meta-bromo-thiolactone, 20-30% of bromination furanone and 10-30% of AIP compounds. The quorum sensing inhibitor is taken as a main component, the quorum sensing behavior of microorganisms in a sewage pipeline can be inhibited, and thus the microorganisms can be prevented from forming biological membranes to block the sewage pipeline.

The production process of d-biotin is one improvement of Sternbach synthesis. The production process includes: the esterification of imidazolone-cis-dicarboxylic acid and methanol in the presence of concentrated sulfuric acid as catalyst to produce racemic monoester; resolution with dextramine; selective reduction of the monoester radical in the resolved matter with sodium borohydride to obtain lactone in required absolute configuration; substitution of oxygen with sulfur in potassium ethyl thioacetate to obtain thiolactone; Grignard reaction to introduce side chain and to obtain keto-olefine acid; hydrogenation with Pd-C catalyst to obtain dibenzyl biotin; and elimination of two benzyl radicals in hot hydroboromic acid to obtain pure optically active d-biotin. The said technological process has short technological path, low cost, simple operation and high yield.

The invention relates to a preparation method of a self-cleaning anti-icing coating based on brush-shaped organic silicon. The preparation method comprises the following steps of: carrying out simplemulti-component click reaction on thiolactone, a diamine compound and monovinyl-terminated polydimethylsiloxane to prepare a dihydroxyl-terminated block, and introducing the dihydroxyl-terminated block into a polyurethane matrix to obtain a brush-shaped organic silicon modified polyurethane coating. The coating with the special structure has the characteristics of low surface energy of organic silicon and strong adhesion between the polyurethane coating and a substrate, and the special brush-shaped structure endows the coating with a special liquid-like surface structure, so that the coating has excellent self-cleaning and anti-fouling properties. The highest tensile strength of the coating can reach 48.62 MPa, the elongation at break of the coating is 1233%, the static water contact angleof the coating is 95 degrees or above, and the minimum ice adhesion force of the surface of the coating can reach 15.4 kPa.

A method for preparing a functionalized polymer, the method comprising the steps, of: (i) polymerizing monomers to form a reactive polymer, and (ii) reacting the reactive polymer with a lactone or thiolactone that contains a protected amino group.

The invention relates to a preparation method and application of a lithium battery binder with self-repairing performance. The method comprises the following steps: adding component A containing dithiolactone functional group and component B containing amino functional group into a solvent, and reacting at 50-100° C. for 12 hours to obtain a lithium battery polymer with self-repairing performance material binder; the component A of the sulfur-containing lactone functional group is N,N'-oxalylthiolactone, N,N'-malonylthiolactone, N,N'-succinylthiolactone lactone, N,N'-glutaryl thiolactone, N,N'-adipyl thiolactone or N,N'-sebacoyl thiolactone; the amino functional group-containing component B is Polyethyleneimine, chitosan, aminocellulose or polylysine. The polymer binder of the present invention can make the positive electrode of the lithium battery have the characteristic of self-repairing, thereby greatly improving the powdering problem of the electrode material, and is beneficial to improving the discharge specific capacity and cycle stability of the lithium battery.

Tin-containing catalysts are provided comprising a compound of formula I.I:L1, L2, L3, and L4 are each independently selected from —O—, —S—, —OC(═O)—, —OC(═S)—, —SC(═O)—, —SC(═S)—, —OS(═O)2O—, —OS(═O)2——N(R6)-, and —OP(═O)(R6)-, wherein R6 represents hydrogen or a monovalent aliphatic, araliphatic, cycloaliphatic or aromatic group having up to 20 carbon atoms. R1, R2, R3, R1′, R2′, and R3′ each independently represent a divalent aliphatic, araliphatic, cycloaliphatic or aromatic group having up to 20 carbon atoms; and R4, R5, R4′, and R5′ each independently represent hydrogen or a monovalent residue derived from reaction of a respective N—H group with an isocyanate, an ethylenically unsaturated compound, a lactone, a dilactone, a thiolactone, a lactam, a thiolactam, a carboxylic acid or derivative thereof, or an epoxide. Also provided are curable compositions containing these catalysts and methods of controlling the rate of cure of curable compositions.

The invention relates to a polymer for conveying genes, a preparation method and application of the polymer, wherein the polymer is represented by a formula shown in the description.

The invention discloses an anti-pollution antibacterial PTFE oil-water separation membrane and a preparation method thereof. The preparation method comprises the following steps: 1) reacting DL-homocysteine thiolactone hydrochloride with acryloyl chloride to prepare thiolactone acrylamide; 2) preparing a random copolymer of dimethylaminoethyl methacrylate and thiolactone acrylamide, wherein the number-average molecular weight of the copolymer is 20000 to 50000 Da; 3) immersing the clean polytetrafluoroethylene membrane into a catecholamine / trihydroxymethyl aminomethane solution to deposit for 4 to 24 hours, and then cleaning and drying to obtain a deposited membrane; and 4) dissolving glucosamine and the copolymer into a trihydroxymethyl aminomethane solution, immersing the deposited membrane into the solution for 24 hours, and then cleaning and drying to obtain a modified membrane. The anti-pollution antibacterial PTFE oil-water separation membrane has excellent hydrophilic performance and antibacterial performance, the application range of the polytetrafluoroethylene membrane is expanded, a new thought is provided for functional modification of the surface of the polymer membrane, the operation process is simple and convenient, and special equipment is not needed.

The invention discloses a Si-rhodamine B derivative, a preparation method and applications thereof. The provided Si-rhodamine B derivative is Si-rhodamine B thiolactone (Si-RBS for short), and is represented by the structural formula I. The Si-rhodamine thiolactone solution is colorless and fluorescent, and is capable of selectively carrying out color developing and fluorescence triggering reactions with Hg2+. Furthermore, a system with an excellent optical performance can be formed in the colorless solution, and thus the sensitivity and selectivity of Hg2+ detection are both greatly improved. So Si-rhodamine B thiolactone can be used to carry out high sensitive and high selective detection on Hg2+, and the detection can be performed in a mode of absorption spectrum or fluorescence spectrum.

The invention discloses an anti-inflammatory drug and use thereof. The drug comprises a chiral compound of formula I, or a pharmaceutically acceptable salt, solvate or deuterate thereof; W and Z are independently selected from hydrogen, substituted or unsubstituted C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkoxy, C1-C6 alkylamino, monocyclic aryl, monocyclic aryloxy or monocyclic heteroaryl; the substitution means that the substance is substituted by one or more groups selected from halogen, C1-C6 alkyl, nitro, amino or hydroxyl; ring A is selected from monocyclic or bicyclic heteroaryl, C3-C6 lactonic ring, C3-C6 lactam ring and C3-C6 thiolactone ring; and alpha and beta are two chiral sites in the compound, and an absolute configuration of alpha and beta are each independently selected froman S or R configuration. The compound disclosed by the invention has remarkable anti-inflammatory effects and is expected to become a new type of non-steroidal anti-inflammatory drugs.

The invention relates to an innovation-type preparation method of an ertapenem side chain (represented by the formula 1). The method comprises the steps: (1) with amino protected thiolactone (represented by the formula I) as a raw material, under an acidic condition, with SiO2 and gamma-Al2O3 as carriers, and with a catalyst prepared with palladium as an active ingredient, carrying out a hydrogenation deprotection reaction, to obtain deprotected thiolactone (represented by the formula 2); and (2) carrying out a reaction of the compound 2 and m-aminobenzoic acid, to obtain the target compound (represented by the formula 1). With easily-available, relatively-inexpensive and amino protected thiolactone having a mature preparation process as the raw material, the improved palladium catalyst is innovatively used for hydrogenation deprotection, the compound 2 is obtained, and then the compound 2 is subjected to a reaction with m-aminobenzoic acid to prepare the target compound; the preparation method has the advantages of cheap and easily available raw materials, high product yield, low production cost, economy, safety and environmental protection, and is more suitable for industrialized production.

The invention discloses biotin and a preparation method thereof. The preparation method comprises the following steps: (1) preparing a product 1 and a product 2; (2) preparing a product 3; (3) preparation of thiolactone; (4) preparing an ethanol solution of the Grignard substance; (5) preparing a hydrogenated product ethanol solution; (6) synthesizing biotin; and (7) refining biotin. The invention provides the biotin and the preparation method thereof, the method is safe and environment-friendly, the d-biotin can be simply and conveniently obtained with high yield, the industrial production efficiency of the d-biotin is improved, and the production cost is reduced.

The present invention relates to a process for the preparation of enantiomerically pure homocysteine-³-thiolactone comprising optical resolution of racemic homocysteine-³-thiolactone ( I ) with a chiral organic acid wherein one isomer is recovered as diastereomeric salt with the organic acid and the other isomer remaining in the mother liquor is submitted to racemisation with a catalytic amount of an aromatic aldehyde and submitted again to optical resolution with the same chiral organic acid.