53 results about "Aminolysis" patented technology

This invention relates to the field of slow rebound foam technology, and particularly to a slow rebound foam based on waste PET polyether polyol, and its preparation method. The waste PET-based polyether polyol is obtained from bis(2-hydroxyethyl) terephthalamide obtained by aminolysis of waste PET as a starting material. This not only enables the recycling and reuse of waste PET, but also allows it to be used as a foaming material for slow rebound foam. The composite polyether is composed of polyether polyol I, polyether polyol II, waste PET-based polyether polyol, and polymer polyol. By adjusting and controlling parameters such as functionality, molecular weight, hydroxyl value, viscosity, and propylene oxide content of the waste PET-based polyether polyol, it can be stably stored at room temperature without crystallization. When used as the soft segment of slow rebound foam, it significantly improves the low-temperature resistance of the slow rebound foam, avoiding the problems of slow rebound polyurethane foam hardening and becoming difficult to cut in winter, as well as poor resilience.

The invention belongs to the technical field of organic compounds, and particularly discloses an indolinone compound and a synthesis method thereof. The molecular structural formula of the indolinone compound is shown as a formula (A), and the synthesis method of the indolinone compound comprises the following steps: S1, carrying out an amide condensation reaction on a compound shown as a formula (1) to generate a compound shown as a formula (2); s2, performing aminolysis reaction on the compound as shown in the formula (2) to generate a hydrazide compound as shown in a formula (3); s3, carrying out nucleophilic substitution reaction on the compound as shown in the formula (4) to generate a compound as shown in a formula (5); and S4, carrying out condensation reaction on the compound as shown in the formula (3) and a compound as shown in a formula (5) to generate the indolinone compound as shown in a formula (A). The indolinone compound provided by the invention is novel in structure, mild and simple in synthesis method and high in yield, and the indolinone compound is also found to be effective in antibiosis.

The invention discloses a nitrogen-containing inorganic-organic hybrid material and a preparation method thereof, and belongs to the technical field of inorganic-organic hybrid materials. In order to solve the problems of low nitrogen content, few chemical bonds formed by inorganic ions and nitrogen and high price of used nitrogen-containing organic ligands in the existing nitrogen-containing inorganic-organic hybrid material preparation technology, the invention provides a method for preparing a nitrogen-containing inorganic-organic hybrid material by using organic amine (H2N-R-NH2, in which R is alkyl) at least containing two terminal-NH2 groups as a nitrogen source. A precursor with the structure of Mx < + > (NH-R-NH2) n (n represents the number of organic amine ligands) is formed through aminolysis reaction of-NH2 groups and inorganic cations (Mx < + >, x represents the valence state of the inorganic cations), and then the nitrogen-containing inorganic-organic hybrid material with the structure of (m center coordination cation number) is formed through polymerization reaction between the precursor and the organic amine ligands. The preparation method has the advantages of simple process flow, no use of expensive organic raw materials and solvent systems, good economical efficiency and good industrial application prospect.

The application discloses antibacterial one-way moisture-conducting polyester fabric based on single-side aminolysis and oxidation dextrin cross-linking and a preparation method thereof, and belongs to the technical field of textile fabric finishing. Amino groups are introduced into the single-side surface of the polyester fabric through an aminolysis reaction to form an amino-modified layer; the amino-modified layer is covalently grafted with oxidation dextrin and a quaternary ammonium salt block copolymer; amino groups are introduced into the single side of the polyester fabric through aminolysis modification, and the quaternary ammonium salt block copolymer is coupled with the oxidation dextrin, wherein the oxidation dextrin is covalently grafted on the surface of the polyester fabric through Schiff base reaction of aldehyde groups and amino groups, and the quaternary ammonium salt block copolymer is covalently connected with the oxidation dextrin through acetal reaction; through the synergistic effect of the oxidation dextrin and the quaternary ammonium salt copolymer designed by single-side modification, the high-efficiency antibacterial performance and one-way moisture-conducting function of the polyester fabric are simultaneously achieved.

The invention belongs to the field of polymer chemistry, and particularly relates to a resin for decoloring gynostemma pentaphylla and a preparation method and application thereof, and the preparation method comprises the following steps: S1, mixing a water phase and an oil phase, standing, shaping, carrying out polymerization reaction, and removing a pore-foaming agent to obtain an acrylonitrile copolymer matrix resin; s2, mixing the acrylonitrile copolymer matrix resin with a first solvent, alkali and a nucleophilic reagent, and performing aminolysis reaction to obtain amide resin; and S3, mixing the amide resin with a second solvent, and carrying out Hofmann degradation to obtain the resin for decoloring the gynostemma pentaphylla. According to the preparation method, amide resin is prepared firstly and then converted into primary amine through Hofmann degradation, weak base functional groups can be connected to decolorizing resin, weak base resin with amino (-NH2) functional groups is prepared and used for decolorizing gynostemma pentaphylla, and the decolorizing rate is increased and the loss of active ingredients is reduced.

This invention discloses a method for synthesizing chiral quinoxalones. Using a copper salt, a chiral ligand, and a base as a catalytic system, the target chiral quinoxalone compound is obtained by reaction in an organic solvent. This invention utilizes an economical and readily available copper catalyst, constructing C-N bonds through propargyl substitution and aminolysis of the ester group to synthesize chiral quinoxalones. This method has advantages such as good substrate universality, high yield, good enantioselectivity, and ease of industrial production. The synthesis method of this invention does not require the use of special and expensive catalysts, and the reaction conditions are simple, requiring no special reaction environment such as high-pressure hydrogen, with low requirements for reaction equipment, making it easy to scale up for industrial production.

The present application relates to a kind of liquid regeneration polyester-based diols based on waste PET and its preparation method.The liquid regeneration polyester-based diols are composed of bis (2-hydroxyethyl) terephthalamide, epsilon-caprolactone, third copolymer component, organic solvent, catalyst, hydrogen bond donor.Bis (2-hydroxyethyl) terephthalamide obtained by waste PET aminolysis and epsilon-caprolactone are used as raw materials, and third copolymer component is introduced, and ring-opening copolymerization is carried out under the action of catalyst and hydrogen bond donor, to obtain liquid regeneration polyester-based diols.The advantages of the present application are that bis (2-hydroxyethyl) terephthalamide obtained by waste PET aminolysis is used to prepare liquid regeneration polyester-based diols, the crystallization phenomenon of traditional polyester-based diols at room temperature is inhibited, the flowability problem is improved, and it is used for industrial polyurethane slow-rebound sponge foaming, which can improve the physical and mechanical properties of slow-rebound sponge.

The application discloses an ionic polymer adhesive prepared based on PET degradation and a preparation method thereof, and comprises the following steps: an amine group or a hydroxyl group is arranged at one end of a small molecule with an organic cation precursor, and the other end of the small molecule is arranged with the organic cation precursor; an intermediate is obtained by carrying out an aminolysis or an ester exchange reaction on the small molecule and PET; an ionization reaction is carried out on the intermediate and a halogenated hydrocarbon to obtain an organic ionic compound; an anion exchange reaction is carried out by mixing a solution of the organic ionic compound with a salt solution containing a target anion to obtain an organic ionic monomer compound; and the organic ionic monomer compound is heated to carry out a polymerization reaction to obtain the ionic polymer adhesive prepared based on PET degradation. The PET is converted into a small molecule compound through the aminolysis / ester exchange reaction, the organic ionic monomer compound is prepared through the ionization reaction and the anion exchange reaction, the three-dimensional polymer network is formed by dehydration and polymerization and cross-linking, the ionic polymer adhesive has excellent adhesion, and meanwhile, the ionic polymer adhesive can be recycled and repeatedly bonded under specific conditions.

The application belongs to the technical field of organic synthesis and specifically relates to a preparation process of high-efficiency taurine. The process specifically comprises the following steps: S1, raw material solution preparation and mother liquor threshold reuse; S2, construction of an aminolysis selective chemical environment; S3, aminolysis reaction; S4, deamination and clarification filtration; S5, segmented acidification-crystallization coupling; S6, crystal throwing and controlled cooling crystallization; S7, solid-liquid separation, washing and drying; and S8, mother liquor threshold detection and closed-loop reuse. The application constructs an aminolysis selective control, acidification-crystallization purification and mother liquor threshold reuse synergistic closed-loop process, stably controls a reaction system, dynamically determines an end point, and inhibits by-product generation from the source; segmented acidification and temperature-controlled crystallization are adopted to improve the purity of crystals and the first-time pharmaceutical-grade qualified rate; and the mother liquor is recycled according to a multi-index threshold access, thereby blocking impurity accumulation.

This invention relates to the field of organic catalysis and discloses a method for catalyzing the ammonolysis of bis(hexamethylene)triamine. The catalyst comprises a support and a main active component and an auxiliary agent supported on the support. The main active component is Ni, the auxiliary agent includes La, and the support comprises alumina, with the alumina content being 50-80 wt% of the total weight of the support. Using the method of this invention, high conversion and selectivity can be obtained when catalyzing the ammonolysis of bis(hexamethylene)triamine, and the catalyst also exhibits high stability.

A method for depolymerizing rigid polymeric polyurethane (PUR) or polyisocyanurate (PIR) foams involves grinding the foams to form a powder, adding the powder to liquid aliphatic amines to obtain a reaction mixture, and performing an aminolysis reaction on the reaction mixture under an inert atmosphere at elevated temperatures and extended incubation times. The process allows for the recovery of polymeric methylene diphenyl diisocyanate (PMDA) in high purity and high yields from the depolymerized foams. The method also includes recovering PMDA by precipitation and using it as a precursor to obtain polymeric methylene diisocyanate (PMDI) for the synthesis of PUR and PIR foams.

The application belongs to the technical field of drug chemical synthesis, and particularly relates to a preparation method of an FGFR2 inhibitor Lirafugratinib (RLY-4008). The reaction steps of the synthetic method are as follows: 2-bromo-p-nitroacetophenone is reacted with 3-amidinopropionic acid ethyl ester hydrochloride, then is ring-closed with formamide (formamidine) to obtain a key intermediate 4-hydroxy-6-(4-nitro-phenyl)-7H-pyrrolo[2,3-d]pyrimidine, halogenation, aminolysis, methylation, suzuki coupling reaction, reduction, and finally reaction with methacryloyl chloride to obtain Lirafugratinib (RLY-4008).

The application discloses a preparation method of hexamidine. The preparation method is as follows: 1,6-(p-cyanophenyl) hexane diether (I) is subjected to alcoholysis reaction with alcohol under the catalysis of a solid superacid, and after the reaction, compound (II) is obtained; the solid superacid is removed through filtration, then ammonia is directly added into the filtrate to generate aminolysis reaction, and hexamidine shown in formula (III) is prepared. The solid superacid is selected to replace traditional acid and alkali, the solid superacid can be recycled for multiple times, the reaction process is simple, green and environment-friendly, the yield is high, and the method is suitable for large-scale industrial production.

The invention discloses an ionic polymer adhesive prepared based on PET degradation and a preparation method of the ionic polymer adhesive. The preparation method comprises the following steps: carrying out aminolysis or ester exchange reaction on PET and a small molecule of which one end is provided with amino or hydroxyl and the other end is provided with an organic cation precursor to obtain an intermediate; carrying out ionization reaction on the intermediate and halogenated hydrocarbon to obtain an organic ionic compound; mixing the organic ion compound solution with a salt solution containing target anions for anion exchange reaction to obtain an organic ion monomer compound; and heating the organic ionic monomer compound for polymerization reaction to obtain the ionic polymer adhesive prepared based on PET degradation. According to the preparation method, PET is converted into a small molecule compound through aminolysis / ester exchange reaction, an organic ion monomer compound is prepared through ionization reaction and anion exchange reaction, a three-dimensional polymer network is formed through dehydration polymerization and mutual cross-linking, the adhesive property is excellent, and meanwhile recycling and repeated bonding can be achieved under specific conditions.

The invention provides a preparation process for co-production of methoxyamine hydrochloride and N, O-dimethyl hydroxylamine hydrochloride. Comprising the steps of aminolysis, methylation reaction, extraction separation, primary hydrolysis, distillation, dehydration and recrystallization of a first product, secondary hydrolysis, dehydration and recrystallization of a second product and the like. According to the invention, methoxyamine hydrochloride and N, O-dimethyl hydroxylamine hydrochloride can be prepared at the same time, and reaction conditions can be greatly widened, so that high-efficiency and high-yield production is realized, and meanwhile, the product purity is greatly improved; through the coproduction design, the equipment utilization rate is high, the cost is greatly reduced, the recovery rate of solution substances such as methyl acetate, dichloromethane, toluene, methanol and isopropanol is greater than or equal to 90%, the wastewater is circulated and zero discharged after being treated, only a small amount of common industrial waste salt is used as solid waste, the hazardous waste amount is greatly reduced, and the effect of environmental protection is achieved.

The invention relates to a liquid-phase synthesis method and application of 5 '-triphosphoric acid modified oligonucleotide. The liquid-phase synthesis method comprises the following steps: synthesis of 5'-terminal phosphoric acid modified oligonucleotide, ammonolysis, salting-out, activation of 5 '-terminal phosphoric acid, connection of pyrophosphoric acid and ethanol precipitation. According to the invention, a liquid phase method is creatively designed to synthesize the oligonucleotide modified by triphosphoric acid, the dependence on a solid phase carrier can be avoided, the synthesis process is safe, the synthesis efficiency is high, the application scene of the synthesis is obviously expanded, and safe, stable and cheap synthesis of the oligonucleotide modified by 5 '-triphosphoric acid is realized.

The invention relates to the technical field of organic compounds, in particular to a method for preparing aminocapronitrile through aminolysis of caprolactam. The method comprises the following steps: in the presence of an MOFs catalyst, carrying out ammonolysis reaction on caprolactam to obtain aminocapronitrile, wherein the MOFs catalyst is a metal organic framework material which is formed by self-assembly of metal ions and phosphonic acid ligands through coordinate bonds and has a porous structure; the metal ions are selected from at least one of Zn < 2 + >, Co < 2 + >, Ni < 2 + >, Al < 3 + > and Zr < 4 + >; the phosphonic acid ligand is selected from at least one of a monophosphonic acid ligand and a polydentate aromatic phosphonic acid ligand. The MOFs catalyst can safely and effectively catalyze caprolactam ammonolysis to prepare aminocapronitrile, the catalytic efficiency is high, the stability is good, and the reaction conditions for preparing aminocapronitrile through caprolactam ammonolysis are mild.

The invention relates to the technical field of hydroxyalkylamide preparation, in particular to a hydroxyalkylamide preparation process and a hydroxyalkylamide preparation system.The preparation process comprises the steps of material preparation, aminolysis reaction, discharging and packaging and warehousing. According to the process, the potential safety hazards that raw materials are flammable, explosive and toxic are avoided, the production operation safety is guaranteed, and the production cost is reduced. When the preparation system provided by the invention is used for production, the reaction selectivity can be improved, the generation of byproducts such as esters can be inhibited, the yield and the purity of a target product can be improved, and industrial continuous production requirements can be met; the extension amount of the material stirring plates can be adjusted to adapt to material viscosity changes in different reaction stages, meanwhile, the extension amount of the material stirring plates on the two material stirring rollers can be dynamically adjusted, the situation that the radial span of the stirring mechanism is single is avoided, and the plugging plate is adjusted and controlled by the adjusting mechanism to swing to different states to adapt to various working conditions.

The invention provides a method for preparing high-heat-resistance and high-transparency polyesteramide by recycling waste PET (polyethylene terephthalate), which comprises the following steps: (1) carrying out alcoholysis reaction on a first raw material system comprising waste PET, an alcoholysis agent and an alcoholysis catalyst to obtain an alcoholysis system; (2) carrying out aminolysis reaction on a second raw material system containing the alcoholysis system, a diamine aminolysis agent and an aminolysis catalyst to obtain an aminolysis system; (3) carrying out exchange reaction on the aminolysis system to obtain an exchange system and an alcoholysis agent recovery system; the exchange reaction comprises ester exchange reaction and / or amide exchange reaction; and (4) carrying out polymerization reaction on the to-be-polymerized system comprising the exchange system to obtain regenerated polyesteramide. The PET recovery method provided by the invention is simple and efficient, and the waste polyester can be effectively upgraded into a high-added-value and high-functionalization material.

The application provides a synthesis method of apixaban and a preparation method of an intermediate thereof. The method takes a key intermediate IX as a raw material, and obtains apixaban (formula I) through oxidation, elimination, addition, reduction and aminolysis successively. The synthesis route of the application is rationally designed, reaction conditions are mild, operation is simple, the yield is high, the process is economical, and the route is easy to be produced on an industrial scale.

The invention provides a water-resistant silicon-based antioxidant as well as a preparation method and application thereof, and belongs to the technical field of wood-plastic composite material preparation aids. The invention discloses a preparation method of 3-(3, 4-dichlorophenyl)- The preparation method comprises the following steps: carrying out aminolysis reaction on 2, 5-di-tert-butyl-4-hydroxyphenyl) methyl propionate and diisopropanolamine, and then carrying out grafting reaction on methyl phenyl dichlorosilane and hydroxyl of the aminolysis product to introduce an organic silicon chain segment; finally, the reaction intermediate of dichlorodiethylsilane and N-methyl-3-aminopropyltrimethoxysilane participates in chain segment polymerization, and a coupling agent chain segment is introduced. A chain segment of a final product contains amide, amino, trimethoxy and ethyoxyl groups, so that wood flour, inorganic filler and the like are favorably combined with plastic, and an organic silicon-based antioxidant product with antioxidant and coupling functions is obtained. The product is used in wood-plastic composite material processing, and has the effects of enhancing the water boiling resistance and water boiling loss resistance of the wood-plastic surface.

The invention belongs to the field of chemical synthesis. The invention particularly relates to a synthesis method of fluopyram. A synthesis method of fluopyram comprises the following steps: reacting a compound shown in a formula III under the action of a hydrogenation catalyst to generate a compound shown in a formula II, and carrying out aminolysis reaction on the compound shown in the formula II and a compound shown in a formula VIII under the action of a catalyst alkali to generate fluopyram. According to the method disclosed by the invention, the use of a noble metal catalyst such as palladium carbon is avoided, the complicated operation of ammonia charging and discharging when cobalt or nickel is used for hydrogenation reduction of cyano groups is avoided, and the three-waste cost is reduced. The operation procedures are reduced, and economic and environment-friendly benefits are generated.

The application relates to the technical field of roxadustat, and particularly discloses a preparation method of roxadustat, which comprises the following steps: S1, taking 4-bromobenzyl bromide as a starting raw material, refluxing 4-bromobenzyl bromide and sodium methoxide in methanol to prepare an intermediate 2; S2, subjecting the intermediate 2 to a Friedel-Crafts acylation reaction with acetic anhydride to prepare an intermediate 3; S3, subjecting the intermediate 3 to an Ullmann coupling reaction with phenol in toluene by using glycine copper as a catalyst to prepare an intermediate 4; the starting raw material is 4-bromobenzyl bromide, the raw material is easy to obtain and low in price, a low-cost conventional reagent is used as a catalytic system, and cheap catalytic systems are used in key reactions, and low-cost alkali-solvent combinations are selected for steps such as aminolysis, so that the preparation cost is greatly compressed from the aspects of raw materials and reagents.

The application relates to the technical field of organic synthesis, and discloses a method for preparing tadalafil or epi-tadalafil, which comprises the following steps: reacting N-(1,3-benzodioxol-5-methyl)-D-tryptophan methyl ester with Fomc-Ala-Cl to prepare compound IIa or compound IIb; and performing a deprotection / aminolysis reaction and a cyclization reaction on the compound IIa or the compound IIb in the presence of methylamine to prepare tadalafil or epi-tadalafil. Through the selection of a specific (Fomc-Ala-Cl) acylation reagent, the purity and / or yield of the compound IIa or the compound IIb are improved, so that the yield and / or purity of the tadalafil and / or epi-tadalafil are improved.

Polycarbonate oligomers, a method for manufacturing polycarbonate oligomers, a curable composition, an epoxy crosslinked product, and a method for degrading an epoxy crosslinked product by gaamine degradation are provided. The polycarbonate oligomer comprises a structure represented by Structural Formula I, Structural Formula I is defined herein.

The application relates to the technical field of organic compounds, in particular to a method for preparing aminocapronitrile by caprolactam aminolysis; the method comprises the following steps: in the presence of a MOFs catalyst, performing aminolysis reaction on caprolactam to obtain the aminocapronitrile; wherein the MOFs catalyst is a metal-organic framework material with a porous structure formed by self-assembly of metal ions and phosphonic acid ligands through coordination bonds; the metal ions are selected from at least one of Zn 2+ , Co 2+ , Ni 2+ , Al 3+ and Zr 4+ ; and the phosphonic acid ligands are selected from at least one of monophosphonic acid ligands and multidentate aromatic phosphonic acid ligands. The MOFs catalyst can safely and effectively catalyze the preparation of aminocapronitrile by caprolactam aminolysis, has high catalytic efficiency, good stability and relatively mild reaction conditions for the preparation of aminocapronitrile by caprolactam aminolysis.

The application discloses a method for recycling polyester by amine decomposition under rare earth catalyst, comprising: under the catalysis of a rare earth catalyst, waste polyester and imidazole salt substances are subjected to amine decomposition reaction to obtain a crude product; the waste polyester comprises at least one of polyethylene terephthalate, polytrimethylene terephthalate, polyethylene isophthalate, polytrimethylene isophthalate, polyethylene succinate, polyethylene adipate, polyethylene suberate and polyethylene sebacate; the crude product is hydrolyzed in an alkali solution, extracted, and the organic phase is taken to obtain hydroxyethyl imidazole salt substances and / or hydroxypropyl imidazole salt substances; the water phase is acidified and precipitated, and solid-liquid separation is performed to obtain organic diacid. The application can utilize a large amount of recycled polyester materials, one-pot method is used to recycle dibasic carboxylic acid and imidazole salt value-added chemicals, and the recycled dibasic carboxylic acid and imidazole salt value-added chemicals can be applied to the polyester industry again.

The application belongs to the technical field of pharmaceutical chemistry, and discloses a kind of aminoacridine compounds with multi-electron-withdrawing substituent group with broad-spectrum antibacterial activity and can kill bacteria quickly and a preparation method and purposes thereof.The compounds are prepared by Ullmann coupling reaction, ring closure reaction and aminolysis reaction, and the structures of the compounds are shown in formula I-III.Bacteriostatic activity experiment research shows that the compounds have clear bacteriostatic activity on various coccobacilli and bacilli, the minimum inhibitory concentration (MIC) of the compounds on staphylococcus aureus and staphylococcus epidermidis reaches 0.25 μg / mL, and the minimum inhibitory concentration MIC of the compounds on staphylococcus capitis can reach 0.5 μg / mL.The compounds can be used for antibacterial drug development, and have the advantages of high antibacterial activity, broad antibacterial spectrum and fast bactericidal effect.