98 results about "Aminolysis" patented technology

The invention discloses an ionic liquid type catalyst for catalyzing a polyurethane chemical degradation reaction and a preparation method and application thereof.The preparation method comprises the steps that a nitrogen-containing heterocyclic ring compound serves as a matrix and is dissolved in an organic solvent, the nitrogen-containing heterocyclic ring compound is protonized under the influence of acid, then separation and purification are conducted, and the ionic liquid type catalyst is formed; and then applying the ionic liquid type catalyst to a polyurethane chemical degradation reaction. The catalyst can efficiently catalyze various polyurethane chemical degradation reactions including acidolysis, alcoholysis, ammonolysis and alcohol aminolysis, and promotes the polyurethane preparation process when the product is recycled. Under the synergistic effect of cations and anions, the catalyst provided by the invention realizes more efficient treatment on polyurethane, and solves the problems that the existing polyurethane chemical degradation catalyst has fewer types, the catalytic efficiency and metal ions interfere with preparation of regenerated products and the like.

The invention discloses a high-barrier material based on a PET aminolysis monomer and a preparation method of the high-barrier material, and belongs to the technical field of high polymer materials. The preparation method comprises the following steps: carrying out aminolysis reaction on polyethylene glycol terephthalate (PET) to prepare a dihydric alcohol monomer containing an amido bond, and carrying out polymerization reaction on the dihydric alcohol monomer and aliphatic dibasic acid to prepare a polyesteramide (PEA) material. The prepared PEA material has excellent oxygen barrier property and toughness, the oxygen barrier property of the PEA material is obviously superior to that of a PET material, and the barrier property and mechanical property of the PEA material can be regulated and controlled by changing the length of a methylene chain segment of the aliphatic dibasic acid monomer. The aliphatic dibasic acid monomer can be derived from biomass resources, the reaction condition is mild, the process is simple, and the method is suitable for industrial large-scale production.

The invention discloses silane modified polyether prepared from an ethoxyquin polymer, which is prepared by the following method: carrying out aminolysis reaction on the ethoxyquin polymer and epoxypropane to prepare amino alcohol; taking amino alcohol as an initiator, and carrying out polymerization reaction on the amino alcohol and epoxypropane to prepare ethyoxyl quinoline polyether polyol; the ethyoxyl quinoline polyether polyol, anhydride and epoxy organosiloxane are subjected to chemical modification, and the silane modified polyether is prepared. According to the method, resource utilization of the ethoxyquin distillation still residues is realized. Due to the introduction of a rigid nitrogen-containing heteroatom quinoline ring structure and an ester bond structure with high cohesive energy, the silane modified polyether prepared from the ethoxyquinoline polymer has the advantages of high strength, strong adhesion, moisture resistance, low odor, environmental protection, no solvent and the like after being cured, can be used for preparing glass cement, sealant, nail-free glue, ceramic tile adhesive and the like, and has wide application prospects. The method can be widely applied to building industry.

The invention belongs to the technical field of organic synthesis, and particularly relates to a preparation method of alkoxyamine hydrochloride, dibasic anhydride is used as a starting material, the alkoxyamine hydrochloride is obtained through aminolysis, alkylation and hydrolysis, C1-C4 alkoxyamine hydrochloride can be prepared through the preparation method provided by the invention, and the alkoxyamine hydrochloride can be prepared by adopting a shrinkage process. The compound II is not separated, the aqueous solution of the compound II is directly used for the next step, the compound III is also directly used for the next step of reaction in a solution form, the process operation is simple, the period is short, the solvent is convenient to recycle and reuse, the waste water is less, and the method has the advantage of industrial popularization.

This invention relates to the field of slow rebound foam technology, and particularly to a slow rebound foam based on waste PET polyether polyol, and its preparation method. The waste PET-based polyether polyol is obtained from bis(2-hydroxyethyl) terephthalamide obtained by aminolysis of waste PET as a starting material. This not only enables the recycling and reuse of waste PET, but also allows it to be used as a foaming material for slow rebound foam. The composite polyether is composed of polyether polyol I, polyether polyol II, waste PET-based polyether polyol, and polymer polyol. By adjusting and controlling parameters such as functionality, molecular weight, hydroxyl value, viscosity, and propylene oxide content of the waste PET-based polyether polyol, it can be stably stored at room temperature without crystallization. When used as the soft segment of slow rebound foam, it significantly improves the low-temperature resistance of the slow rebound foam, avoiding the problems of slow rebound polyurethane foam hardening and becoming difficult to cut in winter, as well as poor resilience.

The invention belongs to the technical field of organic compounds, and particularly discloses an indolinone compound and a synthesis method thereof. The molecular structural formula of the indolinone compound is shown as a formula (A), and the synthesis method of the indolinone compound comprises the following steps: S1, carrying out an amide condensation reaction on a compound shown as a formula (1) to generate a compound shown as a formula (2); s2, performing aminolysis reaction on the compound as shown in the formula (2) to generate a hydrazide compound as shown in a formula (3); s3, carrying out nucleophilic substitution reaction on the compound as shown in the formula (4) to generate a compound as shown in a formula (5); and S4, carrying out condensation reaction on the compound as shown in the formula (3) and a compound as shown in a formula (5) to generate the indolinone compound as shown in a formula (A). The indolinone compound provided by the invention is novel in structure, mild and simple in synthesis method and high in yield, and the indolinone compound is also found to be effective in antibiosis.

The present invention discloses a method for preparing cationic hyaluronic acid microspheres, as well as the resulting products and applications. The method prepares hyaluronic acid polyester microspheres by a water / oil / water double emulsion solvent volatilization method, then introduces amino groups onto the microsphere surfaces through an aminolysis reaction to construct cationic hyaluronic acid microspheres. The microspheres are then applied to moisturizing finishing of textile fabrics. The cations of the microspheres and the anions on the surface of the fabric fibers form an electrostatic force, strengthening the bonding between the microspheres and the fabric, improving the washability of hyaluronic acid textiles, and resolving the problem of hyaluronic acid textiles being unable to retain moisture over the long term.

The invention discloses a nitrogen-containing inorganic-organic hybrid material and a preparation method thereof, and belongs to the technical field of inorganic-organic hybrid materials. In order to solve the problems of low nitrogen content, few chemical bonds formed by inorganic ions and nitrogen and high price of used nitrogen-containing organic ligands in the existing nitrogen-containing inorganic-organic hybrid material preparation technology, the invention provides a method for preparing a nitrogen-containing inorganic-organic hybrid material by using organic amine (H2N-R-NH2, in which R is alkyl) at least containing two terminal-NH2 groups as a nitrogen source. A precursor with the structure of Mx < + > (NH-R-NH2) n (n represents the number of organic amine ligands) is formed through aminolysis reaction of-NH2 groups and inorganic cations (Mx < + >, x represents the valence state of the inorganic cations), and then the nitrogen-containing inorganic-organic hybrid material with the structure of (m center coordination cation number) is formed through polymerization reaction between the precursor and the organic amine ligands. The preparation method has the advantages of simple process flow, no use of expensive organic raw materials and solvent systems, good economical efficiency and good industrial application prospect.

The invention discloses a synthesis method of a carbon dioxide-based alkene / ether / ester group functionalized polyurethane high polymer material, which is a novel method for synthesizing a novel alkene / ether / ester group functionalized polyurethane high polymer material with a clear structure and a specific spatial configuration by taking carbon dioxide platform molecule ethylene carbonate as a raw material and utilizing a hydroxyl-alkyne click reaction. Relates to the technical fields of organic synthesis, polymer synthesis, polymer chemistry, polymer materials and the like. The carbon dioxide-based bifunctional alcohol monomer is efficiently synthesized through aminolysis reaction of diamine and ethylene carbonate, a hydroxyl-alkyne polymerization system is developed, organic phosphine or organic amine which is low in price and easy to obtain is used as a catalyst, addition polymerization reaction of the bifunctional alcohol monomer and the bifunctional alkynoic acid ester monomer under mild conditions is achieved, and the carbon dioxide-based bifunctional alcohol monomer is synthesized. A series of novel alkene / ether / ester group functionalized polyurethane high polymer materials with clear structures and specific spatial configurations are constructed.

The invention discloses a method for efficiently preparing polypeptide interlocking compounds. The prepared polypeptide interlocking structure can improve the physical and chemical stability of polypeptide and enhance the efficacy of polypeptide molecules. The problems of tedious steps, low predictability and poor structural compatibility existing in a few strategies for synthesizing interlocking molecules with polypeptides as skeleton cores at present are solved. According to the invention, crown ether is utilized to activate amino groups in amino acid, and the crown ether and active amino-acid ester of another molecule are subjected to aminolysis reaction, so that the polypeptide interlocking compound can be prepared very efficiently.

The present disclosure provides an aminolysable benzoxazine resin cured product, and a preparation method and an aminolysis method therefor. The preparation method for an aminolysable benzoxazine resin cured product comprises a mixing step and a curing step, wherein in the mixing step, a benzoxazine resin and a phenolic compound are melted and uniformly mixed, so as to obtain a resin composition; and in the curing step, the resin composition is heated to a curing temperature so as to form an aminolysable benzoxazine resin cured product, the curing temperature being 160 to 230°C. Curing is performed by selecting a relatively low temperature, and the phenolic compound is added to promote the curing reaction, such that the prepared benzoxazine resin cured product has good material characteristics and chemical degradability, thereby solving the problem of the benzoxazine resin cured product being difficult to recycle, and achieving the goal of sustainable use.

A method for preparing sodium taurine as a taurine intermediate is provided in the present disclosure. The method comprises the following steps: providing sodium hydroxyethyl sulfonate and an ammonia source; and placing the sodium hydroxyethyl sulfonate and the ammonia source in an aminolysis reactor for an aminolysis reaction to obtain a mixture containing sodium taurine as a taurine intermediate, wherein the molar ratio of ammonia in the ammonia source to the sodium hydroxyethyl sulfonate is greater than or equal to 25:1. A method for preparing taurine is further provided.

The application discloses antibacterial one-way moisture-conducting polyester fabric based on single-side aminolysis and oxidation dextrin cross-linking and a preparation method thereof, and belongs to the technical field of textile fabric finishing. Amino groups are introduced into the single-side surface of the polyester fabric through an aminolysis reaction to form an amino-modified layer; the amino-modified layer is covalently grafted with oxidation dextrin and a quaternary ammonium salt block copolymer; amino groups are introduced into the single side of the polyester fabric through aminolysis modification, and the quaternary ammonium salt block copolymer is coupled with the oxidation dextrin, wherein the oxidation dextrin is covalently grafted on the surface of the polyester fabric through Schiff base reaction of aldehyde groups and amino groups, and the quaternary ammonium salt block copolymer is covalently connected with the oxidation dextrin through acetal reaction; through the synergistic effect of the oxidation dextrin and the quaternary ammonium salt copolymer designed by single-side modification, the high-efficiency antibacterial performance and one-way moisture-conducting function of the polyester fabric are simultaneously achieved.

The invention belongs to the field of polymer chemistry, and particularly relates to a resin for decoloring gynostemma pentaphylla and a preparation method and application thereof, and the preparation method comprises the following steps: S1, mixing a water phase and an oil phase, standing, shaping, carrying out polymerization reaction, and removing a pore-foaming agent to obtain an acrylonitrile copolymer matrix resin; s2, mixing the acrylonitrile copolymer matrix resin with a first solvent, alkali and a nucleophilic reagent, and performing aminolysis reaction to obtain amide resin; and S3, mixing the amide resin with a second solvent, and carrying out Hofmann degradation to obtain the resin for decoloring the gynostemma pentaphylla. According to the preparation method, amide resin is prepared firstly and then converted into primary amine through Hofmann degradation, weak base functional groups can be connected to decolorizing resin, weak base resin with amino (-NH2) functional groups is prepared and used for decolorizing gynostemma pentaphylla, and the decolorizing rate is increased and the loss of active ingredients is reduced.

This invention discloses a method for synthesizing chiral quinoxalones. Using a copper salt, a chiral ligand, and a base as a catalytic system, the target chiral quinoxalone compound is obtained by reaction in an organic solvent. This invention utilizes an economical and readily available copper catalyst, constructing C-N bonds through propargyl substitution and aminolysis of the ester group to synthesize chiral quinoxalones. This method has advantages such as good substrate universality, high yield, good enantioselectivity, and ease of industrial production. The synthesis method of this invention does not require the use of special and expensive catalysts, and the reaction conditions are simple, requiring no special reaction environment such as high-pressure hydrogen, with low requirements for reaction equipment, making it easy to scale up for industrial production.

The present application relates to a kind of liquid regeneration polyester-based diols based on waste PET and its preparation method.The liquid regeneration polyester-based diols are composed of bis (2-hydroxyethyl) terephthalamide, epsilon-caprolactone, third copolymer component, organic solvent, catalyst, hydrogen bond donor.Bis (2-hydroxyethyl) terephthalamide obtained by waste PET aminolysis and epsilon-caprolactone are used as raw materials, and third copolymer component is introduced, and ring-opening copolymerization is carried out under the action of catalyst and hydrogen bond donor, to obtain liquid regeneration polyester-based diols.The advantages of the present application are that bis (2-hydroxyethyl) terephthalamide obtained by waste PET aminolysis is used to prepare liquid regeneration polyester-based diols, the crystallization phenomenon of traditional polyester-based diols at room temperature is inhibited, the flowability problem is improved, and it is used for industrial polyurethane slow-rebound sponge foaming, which can improve the physical and mechanical properties of slow-rebound sponge.

The application discloses an ionic polymer adhesive prepared based on PET degradation and a preparation method thereof, and comprises the following steps: an amine group or a hydroxyl group is arranged at one end of a small molecule with an organic cation precursor, and the other end of the small molecule is arranged with the organic cation precursor; an intermediate is obtained by carrying out an aminolysis or an ester exchange reaction on the small molecule and PET; an ionization reaction is carried out on the intermediate and a halogenated hydrocarbon to obtain an organic ionic compound; an anion exchange reaction is carried out by mixing a solution of the organic ionic compound with a salt solution containing a target anion to obtain an organic ionic monomer compound; and the organic ionic monomer compound is heated to carry out a polymerization reaction to obtain the ionic polymer adhesive prepared based on PET degradation. The PET is converted into a small molecule compound through the aminolysis / ester exchange reaction, the organic ionic monomer compound is prepared through the ionization reaction and the anion exchange reaction, the three-dimensional polymer network is formed by dehydration and polymerization and cross-linking, the ionic polymer adhesive has excellent adhesion, and meanwhile, the ionic polymer adhesive can be recycled and repeatedly bonded under specific conditions.

The application belongs to the technical field of organic synthesis and specifically relates to a preparation process of high-efficiency taurine. The process specifically comprises the following steps: S1, raw material solution preparation and mother liquor threshold reuse; S2, construction of an aminolysis selective chemical environment; S3, aminolysis reaction; S4, deamination and clarification filtration; S5, segmented acidification-crystallization coupling; S6, crystal throwing and controlled cooling crystallization; S7, solid-liquid separation, washing and drying; and S8, mother liquor threshold detection and closed-loop reuse. The application constructs an aminolysis selective control, acidification-crystallization purification and mother liquor threshold reuse synergistic closed-loop process, stably controls a reaction system, dynamically determines an end point, and inhibits by-product generation from the source; segmented acidification and temperature-controlled crystallization are adopted to improve the purity of crystals and the first-time pharmaceutical-grade qualified rate; and the mother liquor is recycled according to a multi-index threshold access, thereby blocking impurity accumulation.

The present invention discloses a key intermediate of edoxaban and a method for synthesizing the same. The key intermediate of edoxaban is [Formula 1] TIFF2024546285000025.tif43170, which can be obtained by aminolysis of the raw material. The intermediate can be used to prepare edoxaban p-toluenesulfonate monohydrate. The new method and route are simple and effectively reduce the cost of producing edoxaban p-toluenesulfonate hydrate on an industrial scale.

The invention discloses a method for preparing etomidate, and relates to the technical field of biological medicines, aiming at the problems of long synthesis steps, poor product purity, darker appearance color, long production period, harsh reaction conditions and existence of impurities difficult to remove in the existing etomidate synthesis method. The etomidate is prepared by taking 1H-imidazole-4-carboxylic acid ethyl ester and 1-chlorophenylethane as raw materials through the processes of aminolysis reaction of halogenated hydrocarbon, resolution, dissociation and refining. The method has the advantages of short route, easiness in operation, stable product quality, suitability for industrial production and the like.

The present invention relates to a method for preparing a key intermediate of sotolacib. The method uses ethyl acetoacetate as a raw material, first reacts with isobutyryl chloride to generate ethyl isobutyryl acetate, and then undergoes substitution, cyclization, aminolysis, and Hofmann rearrangement to obtain the target product, 2-isopropyl-3-amino-4-methylpyridine. The raw materials of the present invention are cheap and readily available, and there are no highly polluting or highly dangerous solvents or catalysts. The post-processing is relatively simple, the product has high purity, high yield, simple operation, low pollution, and low cost. All reactions of the present invention are common reactions, stable and safe, and all intermediate groups are stable, making it a route more suitable for the industrialization of the product.

This invention relates to the field of organic catalysis and discloses a method for catalyzing the ammonolysis of bis(hexamethylene)triamine. The catalyst comprises a support and a main active component and an auxiliary agent supported on the support. The main active component is Ni, the auxiliary agent includes La, and the support comprises alumina, with the alumina content being 50-80 wt% of the total weight of the support. Using the method of this invention, high conversion and selectivity can be obtained when catalyzing the ammonolysis of bis(hexamethylene)triamine, and the catalyst also exhibits high stability.

A method for depolymerizing rigid polymeric polyurethane (PUR) or polyisocyanurate (PIR) foams involves grinding the foams to form a powder, adding the powder to liquid aliphatic amines to obtain a reaction mixture, and performing an aminolysis reaction on the reaction mixture under an inert atmosphere at elevated temperatures and extended incubation times. The process allows for the recovery of polymeric methylene diphenyl diisocyanate (PMDA) in high purity and high yields from the depolymerized foams. The method also includes recovering PMDA by precipitation and using it as a precursor to obtain polymeric methylene diisocyanate (PMDI) for the synthesis of PUR and PIR foams.

The application belongs to the technical field of drug chemical synthesis, and particularly relates to a preparation method of an FGFR2 inhibitor Lirafugratinib (RLY-4008). The reaction steps of the synthetic method are as follows: 2-bromo-p-nitroacetophenone is reacted with 3-amidinopropionic acid ethyl ester hydrochloride, then is ring-closed with formamide (formamidine) to obtain a key intermediate 4-hydroxy-6-(4-nitro-phenyl)-7H-pyrrolo[2,3-d]pyrimidine, halogenation, aminolysis, methylation, suzuki coupling reaction, reduction, and finally reaction with methacryloyl chloride to obtain Lirafugratinib (RLY-4008).

The invention discloses a glycyl glutamine potential impurity and a preparation method thereof, and belongs to the technical field of pharmaceutical analysis. The method comprises the following steps: S1, chloroacetylation: dissolving glutamine in a sodium hydroxide solution, cooling to 0-10 DEG C, dropwise adding chloroacetyl chloride and the sodium hydroxide solution at the same time, maintaining the pH value to be greater than or equal to 9, after the reaction is completed, adding concentrated hydrochloric acid to adjust the pH value to be 1-3, stirring, crystallizing, and carrying out suction filtration to obtain a compound 2; and S2, carrying out halogenated ammonolysis and silica gel column purification: dissolving the compound 2 and glycyl glutamine in an alkaline water solution B, reacting at 20-50 DEG C, adding silica gel after the reaction is completed, carrying out reduced pressure concentration to dry to obtain a solid, carrying out silica gel column chromatography on the solid, and carrying out reduced pressure concentration on an eluent to dry to obtain a potential impurity J. The alkaline water solution B is selected from a sodium carbonate solution or a potassium carbonate solution, the molar ratio of the compound 2 to the glycyl glutamine to the alkaline water solution B is 1: (0.9-1.0): (1.5-3.0), and methanol-dichloromethane-acetic acid is used as an eluent.

The present invention discloses a method for preparing a polyester-based composite hydrophilic material. The method comprises fibrillating small pieces of waste polyester fabric, then surface-amiding the fibers with a 5-30 wt% aqueous solution of diethylenetriamine to obtain aminated polyester fibers. The small pieces of waste polyester fabric are then aminolyzed with diethylenetriamine in the presence of a zinc acetate catalyst to obtain a polyester aminolysis solution, which is diluted and reacted with ethylene glycol glycidyl ether to prepare a crosslinking solution. Finally, the aminated polyester fibers are immersed in the crosslinking solution to obtain the polyester-based composite hydrophilic material. The polyester-based composite hydrophilic material prepared by the method has a static water contact angle of no more than 30°, exhibits excellent hydrophilic properties, and can be used as an adsorbent material in water treatment, particularly in the treatment of dye wastewater.

The application discloses a preparation method of hexamidine. The preparation method is as follows: 1,6-(p-cyanophenyl) hexane diether (I) is subjected to alcoholysis reaction with alcohol under the catalysis of a solid superacid, and after the reaction, compound (II) is obtained; the solid superacid is removed through filtration, then ammonia is directly added into the filtrate to generate aminolysis reaction, and hexamidine shown in formula (III) is prepared. The solid superacid is selected to replace traditional acid and alkali, the solid superacid can be recycled for multiple times, the reaction process is simple, green and environment-friendly, the yield is high, and the method is suitable for large-scale industrial production.

The present invention provides a method for producing anthranilamide derivatives, comprising the following steps: S1) transporting a mixed solution A of anthranilic acid derivatives, a solvent and an organic base and a mixed solution B of triphosgene and a solvent to a first continuous reactor respectively, and performing a cyclization reaction at 55-90° C. to obtain a cyclization reaction liquid; S2) treating the cyclization reaction liquid with an alkali solution to obtain a treated cyclization reaction liquid; S3) transporting the treated cyclization reaction liquid and an organic amine or an aqueous solution of an organic amine to a second continuous reactor respectively, and performing an aminolysis reaction at 55-85° C. to obtain an aminolysis reaction liquid containing anthranilamide derivatives. The present invention adopts a continuous reactor to perform a cyclization reaction at a relatively high temperature, and the obtained cyclization reaction liquid is treated with an alkali solution and directly used for the continuous aminolysis reaction in the next step, thereby simplifying the operation, improving the production efficiency, and omitting the use of a catalyst.

The invention discloses an ionic polymer adhesive prepared based on PET degradation and a preparation method of the ionic polymer adhesive. The preparation method comprises the following steps: carrying out aminolysis or ester exchange reaction on PET and a small molecule of which one end is provided with amino or hydroxyl and the other end is provided with an organic cation precursor to obtain an intermediate; carrying out ionization reaction on the intermediate and halogenated hydrocarbon to obtain an organic ionic compound; mixing the organic ion compound solution with a salt solution containing target anions for anion exchange reaction to obtain an organic ion monomer compound; and heating the organic ionic monomer compound for polymerization reaction to obtain the ionic polymer adhesive prepared based on PET degradation. According to the preparation method, PET is converted into a small molecule compound through aminolysis / ester exchange reaction, an organic ion monomer compound is prepared through ionization reaction and anion exchange reaction, a three-dimensional polymer network is formed through dehydration polymerization and mutual cross-linking, the adhesive property is excellent, and meanwhile recycling and repeated bonding can be achieved under specific conditions.