43 results about "Oxamide" patented technology

The invention discloses high-purity oxamide with concentrated particle size and spherical morphology, a preparation method of the high-purity oxamide and application of the high-purity oxamide in preparation of a slow-release fertilizer, and belongs to the technical field of oxamide synthesis and application. The method comprises the following steps: mixing an ammonia-alcohol solution and an alcohol ester solution, conveying the mixed solution into a series tubular reactor for reaction, and then conveying the mixed solution into a parallel tubular reactor for reaction after pressure stabilization and flow equalization to obtain a reaction solution containing oxamide; performing flash evaporation on the reaction liquid to obtain flash evaporation liquid and flash evaporation gas, and performing solid-liquid separation on the flash evaporation liquid to obtain solid oxamide and filtrate; and drying the solid oxamide to obtain the oxamide. The method realizes high conversion rate and high purity, and the product has ultrafine particle size distribution. The purity of the prepared oxamide is greater than or equal to 99%, the D50 particle size is concentrated to 50 + / -15 microns, the spherical morphology is uniform, the release is stable, and the oxamide has a very good effect in preparation of long-acting slow-release fertilizers and combustion inhibitors and research on the nitrogen utilization rate.

The invention relates to the technical field of oxamide synthesis, and provides a microchannel reactor and a method for synthesizing oxamide by using the microchannel reactor. The micro-channel reactor sequentially comprises a feeding area, a reaction area and a discharging area along the flowing direction of reaction materials; the feeding area comprises a main feeding hole; the reaction area comprises an 8-shaped reaction flow channel, and a plurality of segmented feeding holes are formed in the reaction flow channel; the discharging area comprises a discharging opening. According to the micro-channel reactor provided by the invention, full mixing of raw materials can be realized through segmented feeding, the reaction temperature is effectively controlled, and the local temperature is prevented from being too high; when the microchannel reactor provided by the invention is used for synthesizing oxamide, the process is simple, the reaction conditions are mild, efficient conversion of oxalate can be realized in a short time, continuous production of oxamide is realized, and the microchannel reactor is suitable for industrial production.

The invention relates to the technical field of chemistry, in particular to a synthesis process of 4-fluoro-3, 5-dimethylphenylhydrazine hydrochloride, which comprises the following steps: by taking 4-fluoro-3, 5-dimethylbromobenzene as a raw material and hydrazine hydrate as a hydrazine source, matching with alkali such as potassium hydroxide, sodium hydroxide or potassium phosphate and the like, reacting at the temperature of 60-80 DEG C to obtain the 4-fluoro-3, 5-dimethylphenylhydrazine hydrochloride. The preparation method comprises the following steps: by taking copper or nickel source catalysts such as cuprous bromide, cuprous iodide, nickel salicylate and the like, N, N-bis (2, 6-dimethylphenyl) oxamide as a ligand, hexadecyl trimethyl ammonium bromide as a stabilizer and a dioxane-water mixed system as a solvent, reacting at 80-110 DEG C under the protection of nitrogen, separating a reaction mixed solution after the reaction is finished, and separating the reaction liquid to obtain the target product. And purifying to obtain a finished product of the 4-fluoro-3, 5-dimethyl phenylhydrazine hydrochloride. Therefore, the problems that the synthesis of the 4-fluoro-3, 5-dimethylphenylhydrazine hydrochloride is poor in safety, low in production efficiency, poor in environmental friendliness, small in substrate application range and the like are solved.

The invention belongs to the technical field of functional coatings, and particularly relates to a static conductive coating for nonmetal and a preparation method of the static conductive coating. The coating is composed of modified Si-C fluorosilicone resin, conductive nickel powder, ethandiamide and multiple auxiliaries, the modified Si-C fluorosilicone resin is prepared through a double-grafting reaction of mercaptoethanol and vinyl trifluoroacrylate,-S-and-CF groups are introduced into molecules at the same time, and the polarity of the resin and the dispersity of the conductive nickel powder are remarkably improved. The oxadiamide as a polar small molecule synergist can promote the formation of a conductive network and enhance the interface bonding force. The surface resistivity of the obtained coating is about 2.8 * 10 omega / square, the static decay time is 0.38 s, the adhesive force reaches 5B, and the conductivity retention rate after wear resistance exceeds 97%. The coating has excellent static conductivity, adhesive force and environmental stability, is suitable for the surfaces of non-metal base materials such as ABS, PVC and polycarbonate, and can be widely applied to the fields of electronic equipment shells, rail transit interior trim parts, anti-explosion and anti-static terraces and the like.

The application belongs to the field of high polymer materials, and relates to a high-strength and high-toughness modified PBAT material and a preparation method thereof. The application provides a modified PBAT material, raw materials of the modified PBAT material including low-molecular PBAT, diisocyanate and a small-molecule chain extender, and the modified PBAT material being prepared from the raw materials through melt copolymerization; wherein the small-molecule chain extender is selected from one of pentanediamine, 5-(2-hydroxyethyl)-6-methyl-2-aminouracil, adipic acid dihydrazide, N,N-bis(2-hydroxyethyl)oxamide or 1,6-bis(hydroxyethoxycarbonylamino)hexane. The modified PBAT material has good mechanical strength, which can reach 18-55 MPa, and enhanced fracture toughness (>350 MJ / m 3 ), and the elongation at break can reach 800-1700%.

The application discloses a method for preparing N-ethoxyl oxalyl alanine ester by using a dynamic tubular reactor, which comprises the following steps: (1) reacting L-alanine, diethyl oxalate and 4-dimethylaminopyridine in the dynamic tubular reactor; (2) removing light components from the reaction solution; (3) reacting the reaction solution after removing the light components and ethanol in the dynamic tubular reactor; and (4) obtaining N-ethoxyl oxalyl alanine ester after removing the light components. Compared with traditional kettle reactors and tubular reactors, the method adopts the dynamic tubular reactor to prepare N-ethoxyl oxalyl alanine ester, and through the regulation of reaction parameters, the selectivity of key by-products N-oxamide and double N-oxamide can be effectively controlled below 2%. The process has the advantages of high reaction yield, high degree of continuous operation, significantly shortened reaction time and no use of high-toxicity materials such as benzene.

The present application belongs to the technical field of electronic skin, and particularly relates to a gelled ionic liquid, a preparation method and application thereof, and a gelled ionic liquid electronic skin, a preparation method and application thereof. The gelled ionic liquid is obtained by mixing 1-butyl-3-methyl imidazole tetrafluoroborate and N,N'-di(2-hydroxyethyl)oxamide for gelling. The gelled ionic liquid obtained by the present application retains the wide temperature range characteristics of 1-butyl-3-methyl imidazole tetrafluoroborate, and significantly improves the viscosity and resistance stability thereof. The gelled product is used as a conductive material for preparing stretchable electronic skin, and the electronic skin obtained has high-performance wide temperature range detection capability, and can be flexibly assembled in an array to realize recognition of the number, position and contour of objects placed, recognition of the speed, trajectory and number of objects sliding, and precise recognition of single numbers and complete sentence hand gestures.

The invention discloses a device for preparing oxamide by a continuous method and application of the device in preparation of spherical high-purity oxamide. Belongs to the technical field of oxamide preparation devices. The device comprises a raw material feeding and mixing area, a reaction area, a separation and purification area and a recovery area. The reaction zone comprises a series tubular reactor, a divergent pressure-stabilizing current equalizer and a parallel tubular reactor, and the Y-shaped mixer, the series tubular reactor and the divergent pressure-stabilizing current equalizer are sequentially connected through pipelines; the divergent pressure-stabilizing flow equalizer comprises a divergent pipe body and a flow equalizing grating plate, the flow equalizing grating plate is arranged in the divergent pipe body, and the cross section of the divergent pipe body is gradually increased from the feed port to the discharge port. The device for preparing oxamide through the continuous method has the beneficial effects that the structure is simple, the cost is low, spherical high-purity oxamide can be continuously and efficiently produced, and the device has wide application prospects and high economic value.

The invention discloses a composite organic improving agent and a preparation method and application thereof. The composite organic improving agent is composed of one or more of monooxadiamide derivatives and one or more of bis-oxadiamide derivatives. The composite organic improver can be used for self-assembly heterogeneous nucleation to induce an ethylene polymer molecular chain to form a variant spherocrystal. The preparation method 1 comprises the steps of reacting oxalic acid diester with diamine, adding a solvent for dissolving, adding monoamine for reflux reaction to obtain a product, and the preparation method 2 comprises the steps of reacting oxalic acid diester with monoamine, adding a solvent for dissolving, adding diamine for reflux reaction to obtain a product. The composite organic improver is used as a polymer additive and has excellent effects of reducing turbidity, accelerating crystallization, improving mechanical properties and the like; and the preparation method is short in process, low in cost, few in raw materials and high in yield.

The present invention discloses an application of an oxamide compound in the preparation of an anti-liver cancer drug. The oxamide compound is N-(4,5,6,7-tetrahydro-1H-indazole-5-)-N'-(4-(p-tolyl)phenyl)oxamide, and the molecular formula is C 22 H 22 N4O3, with a molecular weight of 390.44 and a structural formula as shown in Formula (I), investigated the effect of N-(4,5,6,7-tetrahydro-1H-indazole-5-)-N'-(4-(p-tolyl)phenyl)oxalamide on the proliferation of liver cancer cells. The results showed that N-(4,5,6,7-tetrahydro-1H-indazole-5-)-N'-(4-(p-tolyl)phenyl)oxalamide exhibited significant anti-proliferation activity against human liver cancer cells (Hep G2, Hep 3B, PLC / PRF / 5, and Huh7), while exhibiting low toxicity against normal human liver cells (LX-2). This suggests that it possesses strong anti-liver cancer activity and excellent cell selectivity. Therefore, it is expected to be used in the preparation of anti-liver cancer drugs.

The invention discloses an application of a tetrahydroindazole derivative in preparation of a medicine for delaying senescence and prolonging life, the tetrahydroindazole derivative is specifically N-(4-(pyridine-4-) phenyl)-N '-(4, 5, 6, 7-tetrahydro-1H-indazole-5-) oxamide, and the structural formula of the tetrahydroindazole derivative is shown as a formula I. The invention further discloses a preparation method of the tetrahydroindazole derivative. By investigating the influence of N-(4-(pyridine-4-) phenyl)-N '-(4, 5, 6, 7-tetrahydro-1H-indazole-5-) oxamide on the life of caenorhabditis elegans, the obtained experimental result shows that N-(4-(pyridine-4-) phenyl)-N'-(4, 5, 6, 7-tetrahydro-1H-indazole-5-) oxamide has relatively strong anti-aging activity, and can effectively prolong the life of caenorhabditis elegans. Therefore, the compound is expected to be used in preparation and development of medicines for delaying senescence and prolonging life.

The invention relates to an ultraviolet-resistant polyester protective film and a preparation method thereof, and belongs to the technical field of polymer composite materials. The polyester protective film comprises the following components: 5-8 wt% of a flexibilizer, 3.5-5 wt% of a lubricant, 0.18-0.24 wt% of an antioxidant, 0.32-0.45 wt% of a light stabilizer, 0.4-0.5 wt% of an anti-hydrolysis agent, 2.6-3.3 wt% of an anti-reflection agent and the balance of PET resin, 2-chloroaniline and oxalyl chloride react to form an aryl oxamide compound, namely an intermediate, the intermediate and butyl glycolate are substituted and etherified, and the intermediate and butyl glycolate undergo a reaction to form the PET protective film. A butyl-terminated ester structure is introduced, the polarity matching degree with a PET matrix is high, nanoscale uniform dispersion is achieved in the melting and mixing process, a continuous protection network is formed in the polyester matrix, free radicals are efficiently captured, full-wave-band ultraviolet rays are absorbed, aging and yellowing of the film material under the ultraviolet rays are effectively inhibited, the appearance quality of the film material is remarkably improved, and the service life of the film material is remarkably prolonged.

The invention relates to the fields of pesticides and plant protection. Specifically, the invention relates to a novel isoquinoline compound containing an oxamide bridge chain, including a stereoisomer, a prodrug molecule and a pharmaceutically acceptable salt thereof, and application of the molecule in preparation of a bactericide for resisting plant pathogenic fungi. The structure of the isoquinoline compound is shown as a formula (I). The isoquinoline compound disclosed by the invention has obvious inhibitory activity on various plant pathogenic fungi and can be used for preparing bactericides.

The present invention relates to a process for the preparation of N-(5-chloropyridin-2- yl)-N'-[(1S,2R,4S)-4(N,N-dimethylcarbamoyl)-2-(5-methyl-4,5,6,7-tetrahydro [1,3] thiazolo[5,4-c] pyridine-2-carboxamido)cyclohexyl]oxamide, 4- methylbenzenesulfonate. It further relates to a process for the purification of N-(5- chloropyridin-2-yl)-N'-[(1S,2R,4S)-4(N,N-dimethylcarbamoyl)-2-(5-methyl-4,5,6,7- tetrahydro [1,3] thiazolo[5,4-c] pyridine-2-carboxamido)cyclohexyl]oxamide, 4- methylbenzenesulfonate is having purity greater than 99% by HPLC, preferably greater than 99.5% and more preferably 99.9% by HPLC.

The present application relates to the technical field of porous adsorbent production, in particular to a porous adsorbent, a preparation method and application thereof, comprising the following steps: compounding and crushing and screening coal gasification slag and biomass waste to obtain a mixture; stirring the mixture and an alkaline solution containing amine substances at room temperature, then kneading and drying to obtain impregnated mixture; the amine substances are at least one of urea, melamine, oxamide and urea-formaldehyde; the alkaline substances are at least one of KOH, K2CO3, NaOH and Na2CO3; the impregnated mixture is activated under a nitrogen atmosphere, washed with hydrochloric acid, solid-liquid separated and dried to obtain the porous adsorbent. The present application uses coal gasification slag and biomass waste as raw materials, which are cheap and easy to obtain, and realizes the recycling and high value-added conversion thereof.

The invention belongs to the technical field of organic chemistry, and particularly discloses a polymonothiooxamide compound as well as a preparation method and application thereof. The structural formula of the polymonothiooxamide compound is shown in the specification, wherein n is any integer between 2 and 500. The preparation method comprises the following steps: mixing the polyamide disulfide compound, aliphatic diamine, organic alkali and an organic solvent, and reacting to obtain the polymonothiooxamide compound. According to the invention, large-scale preparation of the polymonothiooxamide compound can be realized, and the prepared polymer has excellent optical and mechanical properties.

The present invention relates to the use of a bimetallic supported catalyst, which comprises, on a support, copper and a metal M selected from manganese, cobalt, nickel and iron, of formula Cu-M / support, where M represents Mn, Co, Ni or Fe, respectively, in carrying out a process for the preparation of ethylene glycol from oxamide or oxamate compounds by hydrogenation of said oxamide or oxamate compounds with hydrogen (H) to give ethylene glycol.

The invention provides an oxamido multi-nitrogen-source core-shell structure long-acting slow release fertilizer as well as a preparation method and application thereof. The slow-release fertilizer is of a core-shell structure, the core-shell structure comprises an inner core area and a shell, the inner core area at least comprises a quick-acting core, and raw materials of the quick-acting core comprise a quick-acting nitrogen source, a medium trace element compound, humus, poly-polyhydroxy acid and a first auxiliary agent; the shell is prepared from the following raw materials: slow-release nitrogen source oxamide, a second auxiliary agent and a biological agent. Controllable slow release within 50-200 days is achieved, the nitrogen utilization rate is increased by 1.25-2 times compared with a conventional compound fertilizer, the nitrogen and carbon utilization rate is remarkably increased, and carbon emission to the atmosphere is reduced. The fertilizer can meet the requirements of the whole growth period after being applied once, is suitable for food crops and commercial crops, and has remarkable economic and environmental benefits.

The invention relates to the technical field of compound synthesis, in particular to a preparation method of N, N '-bis (2, 4, 6-trimethoxyphenyl) oxamide. The preparation method comprises the following steps: S1, bromination reaction: mixing dichloromethane, 1, 3, 5-trimethoxybenzene and triethylene diamine, adding NBS (N-bromosuccinimide) or dibromohydantoin, and reacting to obtain 1-bromo-2, 4, 6-trimethoxybenzene; s2, amination reaction: mixing an organic solvent, an acid binding agent, 1-bromo-2, 4, 6-trimethoxybenzene, a cuprous compound and a catalyst, and reacting to obtain 2, 4, 6-trimethoxyaniline hydrochloride; and S3, condensation reaction: mixing the 2, 4, 6-trimethoxyaniline hydrochloride with dichloromethane, adding triethylamine, and dropwise adding oxalyl chloride to obtain the N, N '-bis (2, 4, 6-trimethoxyphenyl) oxamide. The invention provides a preparation method of N, N '-bis (2, 4, 6-trimethoxyphenyl) oxamide, and aims to solve the problems of relatively slow reaction speed, incomplete reaction conversion, generation of impurities, poor product purity and low yield in a synthetic method in related technologies.

The application relates to the fine chemical technology field and discloses a synthesis method of N-(2-ethoxyphenyl)-N'-(2-ethylphenyl) oxamide, which comprises the following steps: carrying out a dehydration condensation reaction on oxalic acid and o-ethylaniline in a green catalyst and a green solvent system to prepare an oxamide acid intermediate; separating and recovering a solvent from the obtained oxamide acid intermediate to improve reaction efficiency and reduce solvent waste; and reacting the prepared oxamide acid intermediate with o-amino phenetole in a synergistic catalyst and a green solvent system to prepare crude N-(2-ethoxyphenyl)-N'-(2-ethylphenyl) oxamide. Through a green catalytic system, an optimized purification process and a resource recovery strategy, the application realizes efficient, low-energy-consumption preparation of oxamide ultraviolet absorbers and green production of high-purity products.

The invention relates to the technical field of slow-release fertilizers, in particular to an oxamido multi-nutrient core-shell structure long-acting slow-release fertilizer and a preparation method thereof. The slow release fertilizer is of a core-shell structure and comprises a shell, an inner layer unit and a core layer, the inner layer unit comprises n inner layer groups, each inner layer group comprises an odd number of layers and an even number of layers, the shell comprises the following raw materials: oxamide and a biological agent, and the raw material of the even number of layers is oxamide; the odd layers comprise the following raw materials: a nitrogen source, a phosphorus source, a potassium source, organic matters, medium trace elements and polyhydroxy acid; components of the core layer are the same as those of the odd layers. Through the unique core-shell structure design, the nitrogen utilization rate reaches 40%-80%, and compared with traditional urea, the nitrogen utilization rate is remarkably improved. The nitrogen fertilizer can effectively meet the requirement of crops for nitrogen in the whole growth period, and also can remarkably reduce waste caused by loss of nutrient elements, so that the agricultural production cost is reduced while the agricultural production efficiency is improved.

The invention provides a high-weather-resistant polycarbonate composite material and a preparation method thereof, and relates to the technical field of composite material preparation, the high-weather-resistant polycarbonate composite material comprises the following components by weight: 70-90 parts of polycarbonate, 1-3 parts of a weather-resistant stable system, and 3-8 parts of a nano inorganic filler, the weather-resistant stable system comprises an ultraviolet light absorber, an antioxidant and a metal deactivator, the ultraviolet light absorber is a benzotriazole compound, the antioxidant is a compound of hindered phenol and phosphite ester compounds, and the metal deactivator is selected from N, N '-diphenyl oxamide; the nano inorganic filler is selected from one or more of nano titanium dioxide, nano silicon dioxide and nano aluminum oxide, and the polycarbonate composite material has excellent damp-heat aging resistance stability.

The application belongs to the technical field of high polymer materials, and particularly discloses a compatilized modified PBAT / PLA / plasticized starch composite material and a preparation method thereof.The preparation raw material of the compatilized modified PBAT / PLA / plasticized starch composite material comprises PBAT, PLA, plasticized starch and a compatilizer.The plasticized starch is oxamide modified starch.The compatilizer is a 3,4-epoxy-1-butene graft of PBAT.The compatilized modified PBAT / PLA / plasticized starch composite material has high tensile strength and elastic modulus, and excellent mechanical properties.

The utility model relates to a vertical homogeneous reactor and an oxamide production system using the same. Comprising a reactor shell, a stirring unit used for achieving uniform mixing of materials is arranged in the middle of the top of the reactor shell, a material outlet pipeline is arranged on one side of the top of the reactor shell, and a first liquid phase material inlet pipeline and a second liquid phase material inlet pipeline are arranged on the two sides of the bottom of the reactor shell respectively; by adopting the form of feeding from the lower part and discharging from the upper part, the materials can stay for sufficient time in the reactor shell, so that the characteristics of improving the utilization rate of the raw materials and realizing sufficient reaction of the raw materials are achieved.

The utility model relates to a spray type device for continuously synthesizing oxamide. Comprising a raw material supply part which is connected with an inlet of a spray type reactor, an outlet of the spray type reactor is connected with a centrifugal machine, a solid phase outlet of the centrifugal machine is connected with an oxamide treatment unit, and a liquid phase outlet of the centrifugal machine is connected with a methanol refining unit; the spray type reactor comprises a reactor shell, at least one group of opposed atomizing nozzles are arranged at the middle upper part of the reactor shell, the group of opposed atomizing nozzles comprise a dimethyl oxalate methanol solution nozzle and an ammonia methanol solution nozzle, and the dimethyl oxalate methanol solution nozzle and the ammonia methanol solution nozzle are oppositely arranged; a solid-liquid phase material outlet is formed in the bottom of the reactor shell; the method has the characteristics of continuous production and low energy consumption.

The invention discloses a polyurethane reaction type hot melt adhesive for bonding a water-swelling sealing rubber strip and a preparation method of the polyurethane reaction type hot melt adhesive, and belongs to the field of adhesives. The hot melt adhesive is prepared by reacting polytetrahydrofuran ether glycol, polycarbonate diol, polyethylene glycol ether glycol, amino-terminated polyether amide and the like with diisocyanate, carrying out chain extension by taking 2, 2 '-dihydroxypropionic acid or N, N'-bis (2-hydroxyethyl) oxamide as a functional chain extender, and adding tackifying resin, a curing agent and the like. The prepared polyurethane reaction type hot melt adhesive has the characteristics that the fixing speed is high, the strength is high, the water absorption swelling degree is matched with a sealing strip, a joint is not broken in a dry state, and the joint does not fall off after absorbing water.

The present invention provides a metal-organic framework material capable of ethylene and propylene adsorption separation and a preparation method. The metal-organic framework material has the chemical formula [Co2(OATA)(DPA)]·4DMF and is prepared using a solvothermal synthesis method using cobalt nitrate hexahydrate, organic ligands N,N'-bis(isophthalic acid)oxamide, and di(pyridin-4-yl)amine as raw materials. The metal-organic framework material prepared by the method of the present invention has a porosity of 56.3%, contains a throat-like pore structure, and has a minimum pore size of only 0.5 nm. The obtained metal-organic framework material exhibits significant preferential adsorption for propylene and weak adsorption for ethylene, resulting in high propylene / ethylene adsorption selectivity and potential application as an adsorption separation material in the field of ethylene and propylene adsorption separation. The present invention also provides a simple process, mild reaction conditions, and uses ligand raw materials from a wide range of sources.

The application discloses a device for preparing oxamide by a continuous method and application of the device in preparation of spherical high-purity oxamide, and belongs to the technical field of oxamide preparation devices. The device comprises a raw material feeding and mixing area, a reaction area, a separation and purification area and a recovery area. The reaction area comprises a series pipe reactor, a gradually-expanded type pressure-stable current distributor and a parallel pipe reactor, and the Y-shaped mixer, the series pipe reactor and the gradually-expanded type pressure-stable current distributor are sequentially connected through pipelines. The gradually-expanded type pressure-stable current distributor comprises a gradually-expanded type pipe body and a current-distributing grid plate, the current-distributing grid plate is arranged in the gradually-expanded type pipe body, and the cross section of the gradually-expanded type pipe body gradually increases from a feeding port to a discharging port. The device for preparing oxamide by the continuous method has the advantages of simple structure, low cost, continuous and efficient production of spherical high-purity oxamide, wide application prospect and high economic value.

The application belongs to the technical field of pharmaceutical chemistry, and particularly relates to an N-antipyrine oxamide ethyl hydrazine group alpha-glucosidase inhibitor, a preparation method and application thereof, and has a chemical structural formula as shown in formula (I): formula (I); in the formula, Ar is one of an aromatic group and a heterocycle. Compared with the prior art, the application solves the problem that the inhibitory effect of the alpha-glucosidase inhibitor in the prior art is insufficient and it is still difficult to meet the inhibitory requirement. The scheme further improves the inhibitory effect of the alpha-glucosidase inhibitor, and the IC 50 value is 7.84+ / -0.17 muM, which is less than 11.45+ / -0.12 muM of acarbose.

The invention discloses an application of a tetrahydroindazole derivative in preparation of a drug for resisting micro-nano plastic toxicity, the tetrahydroindazole derivative is specifically N-((methylphenyl-3-) phenoxy-2-)-N '-(4, 5, 6, 7-tetrahydro-1H-indazole-5-) oxamide, and the structural formula of the tetrahydroindazole derivative is shown as a formula I. The invention further discloses a preparation method of the tetrahydroindazole derivative. By investigating the influence of N-((tolyl-3-) phenoxy-2-)-N '-(4, 5, 6, 7-tetrahydro-1H-indazole-5-) oxamide on the life of caenorhabditis elegans poisoned by the micro-nano plastic, the obtained experimental result shows that N-((tolyl-3-) phenoxy-2-)-N'-(4, 5, 6, 7-tetrahydro-1H-indazole-5-) oxamide has a relatively strong detoxifying effect on the micro-nano plastic. Therefore, the compound is expected to be applied to preparation and development of various micro-nano plastic toxicity resisting drugs.