22 results about "Oxamide" patented technology

The invention discloses high-purity oxamide with concentrated particle size and spherical morphology, a preparation method of the high-purity oxamide and application of the high-purity oxamide in preparation of a slow-release fertilizer, and belongs to the technical field of oxamide synthesis and application. The method comprises the following steps: mixing an ammonia-alcohol solution and an alcohol ester solution, conveying the mixed solution into a series tubular reactor for reaction, and then conveying the mixed solution into a parallel tubular reactor for reaction after pressure stabilization and flow equalization to obtain a reaction solution containing oxamide; performing flash evaporation on the reaction liquid to obtain flash evaporation liquid and flash evaporation gas, and performing solid-liquid separation on the flash evaporation liquid to obtain solid oxamide and filtrate; and drying the solid oxamide to obtain the oxamide. The method realizes high conversion rate and high purity, and the product has ultrafine particle size distribution. The purity of the prepared oxamide is greater than or equal to 99%, the D50 particle size is concentrated to 50 + / -15 microns, the spherical morphology is uniform, the release is stable, and the oxamide has a very good effect in preparation of long-acting slow-release fertilizers and combustion inhibitors and research on the nitrogen utilization rate.

The invention belongs to the technical field of functional coatings, and particularly relates to a static conductive coating for nonmetal and a preparation method of the static conductive coating. The coating is composed of modified Si-C fluorosilicone resin, conductive nickel powder, ethandiamide and multiple auxiliaries, the modified Si-C fluorosilicone resin is prepared through a double-grafting reaction of mercaptoethanol and vinyl trifluoroacrylate,-S-and-CF groups are introduced into molecules at the same time, and the polarity of the resin and the dispersity of the conductive nickel powder are remarkably improved. The oxadiamide as a polar small molecule synergist can promote the formation of a conductive network and enhance the interface bonding force. The surface resistivity of the obtained coating is about 2.8 * 10 omega / square, the static decay time is 0.38 s, the adhesive force reaches 5B, and the conductivity retention rate after wear resistance exceeds 97%. The coating has excellent static conductivity, adhesive force and environmental stability, is suitable for the surfaces of non-metal base materials such as ABS, PVC and polycarbonate, and can be widely applied to the fields of electronic equipment shells, rail transit interior trim parts, anti-explosion and anti-static terraces and the like.

The application belongs to the field of high polymer materials, and relates to a high-strength and high-toughness modified PBAT material and a preparation method thereof. The application provides a modified PBAT material, raw materials of the modified PBAT material including low-molecular PBAT, diisocyanate and a small-molecule chain extender, and the modified PBAT material being prepared from the raw materials through melt copolymerization; wherein the small-molecule chain extender is selected from one of pentanediamine, 5-(2-hydroxyethyl)-6-methyl-2-aminouracil, adipic acid dihydrazide, N,N-bis(2-hydroxyethyl)oxamide or 1,6-bis(hydroxyethoxycarbonylamino)hexane. The modified PBAT material has good mechanical strength, which can reach 18-55 MPa, and enhanced fracture toughness (>350 MJ / m 3 ), and the elongation at break can reach 800-1700%.

The application discloses a method for preparing N-ethoxyl oxalyl alanine ester by using a dynamic tubular reactor, which comprises the following steps: (1) reacting L-alanine, diethyl oxalate and 4-dimethylaminopyridine in the dynamic tubular reactor; (2) removing light components from the reaction solution; (3) reacting the reaction solution after removing the light components and ethanol in the dynamic tubular reactor; and (4) obtaining N-ethoxyl oxalyl alanine ester after removing the light components. Compared with traditional kettle reactors and tubular reactors, the method adopts the dynamic tubular reactor to prepare N-ethoxyl oxalyl alanine ester, and through the regulation of reaction parameters, the selectivity of key by-products N-oxamide and double N-oxamide can be effectively controlled below 2%. The process has the advantages of high reaction yield, high degree of continuous operation, significantly shortened reaction time and no use of high-toxicity materials such as benzene.

The invention discloses a device for preparing oxamide by a continuous method and application of the device in preparation of spherical high-purity oxamide. Belongs to the technical field of oxamide preparation devices. The device comprises a raw material feeding and mixing area, a reaction area, a separation and purification area and a recovery area. The reaction zone comprises a series tubular reactor, a divergent pressure-stabilizing current equalizer and a parallel tubular reactor, and the Y-shaped mixer, the series tubular reactor and the divergent pressure-stabilizing current equalizer are sequentially connected through pipelines; the divergent pressure-stabilizing flow equalizer comprises a divergent pipe body and a flow equalizing grating plate, the flow equalizing grating plate is arranged in the divergent pipe body, and the cross section of the divergent pipe body is gradually increased from the feed port to the discharge port. The device for preparing oxamide through the continuous method has the beneficial effects that the structure is simple, the cost is low, spherical high-purity oxamide can be continuously and efficiently produced, and the device has wide application prospects and high economic value.

The present invention relates to a process for the preparation of N-(5-chloropyridin-2- yl)-N'-[(1S,2R,4S)-4(N,N-dimethylcarbamoyl)-2-(5-methyl-4,5,6,7-tetrahydro [1,3] thiazolo[5,4-c] pyridine-2-carboxamido)cyclohexyl]oxamide, 4- methylbenzenesulfonate. It further relates to a process for the purification of N-(5- chloropyridin-2-yl)-N'-[(1S,2R,4S)-4(N,N-dimethylcarbamoyl)-2-(5-methyl-4,5,6,7- tetrahydro [1,3] thiazolo[5,4-c] pyridine-2-carboxamido)cyclohexyl]oxamide, 4- methylbenzenesulfonate is having purity greater than 99% by HPLC, preferably greater than 99.5% and more preferably 99.9% by HPLC.

The present application relates to the technical field of porous adsorbent production, in particular to a porous adsorbent, a preparation method and application thereof, comprising the following steps: compounding and crushing and screening coal gasification slag and biomass waste to obtain a mixture; stirring the mixture and an alkaline solution containing amine substances at room temperature, then kneading and drying to obtain impregnated mixture; the amine substances are at least one of urea, melamine, oxamide and urea-formaldehyde; the alkaline substances are at least one of KOH, K2CO3, NaOH and Na2CO3; the impregnated mixture is activated under a nitrogen atmosphere, washed with hydrochloric acid, solid-liquid separated and dried to obtain the porous adsorbent. The present application uses coal gasification slag and biomass waste as raw materials, which are cheap and easy to obtain, and realizes the recycling and high value-added conversion thereof.

The invention belongs to the technical field of organic chemistry, and particularly discloses a polymonothiooxamide compound as well as a preparation method and application thereof. The structural formula of the polymonothiooxamide compound is shown in the specification, wherein n is any integer between 2 and 500. The preparation method comprises the following steps: mixing the polyamide disulfide compound, aliphatic diamine, organic alkali and an organic solvent, and reacting to obtain the polymonothiooxamide compound. According to the invention, large-scale preparation of the polymonothiooxamide compound can be realized, and the prepared polymer has excellent optical and mechanical properties.

The present invention relates to the use of a bimetallic supported catalyst, which comprises, on a support, copper and a metal M selected from manganese, cobalt, nickel and iron, of formula Cu-M / support, where M represents Mn, Co, Ni or Fe, respectively, in carrying out a process for the preparation of ethylene glycol from oxamide or oxamate compounds by hydrogenation of said oxamide or oxamate compounds with hydrogen (H) to give ethylene glycol.

The application relates to the fine chemical technology field and discloses a synthesis method of N-(2-ethoxyphenyl)-N'-(2-ethylphenyl) oxamide, which comprises the following steps: carrying out a dehydration condensation reaction on oxalic acid and o-ethylaniline in a green catalyst and a green solvent system to prepare an oxamide acid intermediate; separating and recovering a solvent from the obtained oxamide acid intermediate to improve reaction efficiency and reduce solvent waste; and reacting the prepared oxamide acid intermediate with o-amino phenetole in a synergistic catalyst and a green solvent system to prepare crude N-(2-ethoxyphenyl)-N'-(2-ethylphenyl) oxamide. Through a green catalytic system, an optimized purification process and a resource recovery strategy, the application realizes efficient, low-energy-consumption preparation of oxamide ultraviolet absorbers and green production of high-purity products.

The invention provides a high-weather-resistant polycarbonate composite material and a preparation method thereof, and relates to the technical field of composite material preparation, the high-weather-resistant polycarbonate composite material comprises the following components by weight: 70-90 parts of polycarbonate, 1-3 parts of a weather-resistant stable system, and 3-8 parts of a nano inorganic filler, the weather-resistant stable system comprises an ultraviolet light absorber, an antioxidant and a metal deactivator, the ultraviolet light absorber is a benzotriazole compound, the antioxidant is a compound of hindered phenol and phosphite ester compounds, and the metal deactivator is selected from N, N '-diphenyl oxamide; the nano inorganic filler is selected from one or more of nano titanium dioxide, nano silicon dioxide and nano aluminum oxide, and the polycarbonate composite material has excellent damp-heat aging resistance stability.

The application belongs to the technical field of high polymer materials, and particularly discloses a compatilized modified PBAT / PLA / plasticized starch composite material and a preparation method thereof.The preparation raw material of the compatilized modified PBAT / PLA / plasticized starch composite material comprises PBAT, PLA, plasticized starch and a compatilizer.The plasticized starch is oxamide modified starch.The compatilizer is a 3,4-epoxy-1-butene graft of PBAT.The compatilized modified PBAT / PLA / plasticized starch composite material has high tensile strength and elastic modulus, and excellent mechanical properties.

The utility model relates to a vertical homogeneous reactor and an oxamide production system using the same. Comprising a reactor shell, a stirring unit used for achieving uniform mixing of materials is arranged in the middle of the top of the reactor shell, a material outlet pipeline is arranged on one side of the top of the reactor shell, and a first liquid phase material inlet pipeline and a second liquid phase material inlet pipeline are arranged on the two sides of the bottom of the reactor shell respectively; by adopting the form of feeding from the lower part and discharging from the upper part, the materials can stay for sufficient time in the reactor shell, so that the characteristics of improving the utilization rate of the raw materials and realizing sufficient reaction of the raw materials are achieved.

The invention discloses a polyurethane reaction type hot melt adhesive for bonding a water-swelling sealing rubber strip and a preparation method of the polyurethane reaction type hot melt adhesive, and belongs to the field of adhesives. The hot melt adhesive is prepared by reacting polytetrahydrofuran ether glycol, polycarbonate diol, polyethylene glycol ether glycol, amino-terminated polyether amide and the like with diisocyanate, carrying out chain extension by taking 2, 2 '-dihydroxypropionic acid or N, N'-bis (2-hydroxyethyl) oxamide as a functional chain extender, and adding tackifying resin, a curing agent and the like. The prepared polyurethane reaction type hot melt adhesive has the characteristics that the fixing speed is high, the strength is high, the water absorption swelling degree is matched with a sealing strip, a joint is not broken in a dry state, and the joint does not fall off after absorbing water.

The application discloses a device for preparing oxamide by a continuous method and application of the device in preparation of spherical high-purity oxamide, and belongs to the technical field of oxamide preparation devices. The device comprises a raw material feeding and mixing area, a reaction area, a separation and purification area and a recovery area. The reaction area comprises a series pipe reactor, a gradually-expanded type pressure-stable current distributor and a parallel pipe reactor, and the Y-shaped mixer, the series pipe reactor and the gradually-expanded type pressure-stable current distributor are sequentially connected through pipelines. The gradually-expanded type pressure-stable current distributor comprises a gradually-expanded type pipe body and a current-distributing grid plate, the current-distributing grid plate is arranged in the gradually-expanded type pipe body, and the cross section of the gradually-expanded type pipe body gradually increases from a feeding port to a discharging port. The device for preparing oxamide by the continuous method has the advantages of simple structure, low cost, continuous and efficient production of spherical high-purity oxamide, wide application prospect and high economic value.

The application belongs to the technical field of pharmaceutical chemistry, and particularly relates to an N-antipyrine oxamide ethyl hydrazine group alpha-glucosidase inhibitor, a preparation method and application thereof, and has a chemical structural formula as shown in formula (I): formula (I); in the formula, Ar is one of an aromatic group and a heterocycle. Compared with the prior art, the application solves the problem that the inhibitory effect of the alpha-glucosidase inhibitor in the prior art is insufficient and it is still difficult to meet the inhibitory requirement. The scheme further improves the inhibitory effect of the alpha-glucosidase inhibitor, and the IC 50 value is 7.84+ / -0.17 muM, which is less than 11.45+ / -0.12 muM of acarbose.

The invention discloses an application of a tetrahydroindazole derivative in preparation of a drug for resisting micro-nano plastic toxicity, the tetrahydroindazole derivative is specifically N-((methylphenyl-3-) phenoxy-2-)-N '-(4, 5, 6, 7-tetrahydro-1H-indazole-5-) oxamide, and the structural formula of the tetrahydroindazole derivative is shown as a formula I. The invention further discloses a preparation method of the tetrahydroindazole derivative. By investigating the influence of N-((tolyl-3-) phenoxy-2-)-N '-(4, 5, 6, 7-tetrahydro-1H-indazole-5-) oxamide on the life of caenorhabditis elegans poisoned by the micro-nano plastic, the obtained experimental result shows that N-((tolyl-3-) phenoxy-2-)-N'-(4, 5, 6, 7-tetrahydro-1H-indazole-5-) oxamide has a relatively strong detoxifying effect on the micro-nano plastic. Therefore, the compound is expected to be applied to preparation and development of various micro-nano plastic toxicity resisting drugs.

The invention provides a device and a method for producing oxamide. The device comprises: a reaction device; a gas-liquid separation device; a solid-liquid separation device; a drying device; a coarse rectifying tower; a methanol purification system; washing the condensing tower; provided is an alcohol ester mixer. Relative high-level heat energy generated by ammonolysis reaction is used for drying oxamide powder, relative low-level heat energy is used for reboiling in the coarse rectifying tower, a second alcohol ammonia gas phase generated by the drying device is introduced into the coarse rectifying tower so as to fully utilize heat energy of the coarse rectifying tower, and coarse methanol obtained by the coarse rectifying tower is refined by adopting an adsorption or membrane separation mode. And the ammonia content in the refined methanol can be reduced to 1ppm. According to the technical scheme of the process, ammonolysis reaction heat and drying device gas waste heat are fully utilized, an adsorption or membrane separation process is adopted for methanol refining, and the oxamide production cost can be remarkably reduced. Furthermore, according to the scheme provided by the invention, high-purity methanol can be produced to be sold out or returned to a dimethyl oxalate synthesis section for use.

The invention discloses an oxamide antibacterial nucleating agent and a preparation method thereof in order to solve the problems of complex preparation process, high cost, poor biocompatibility, potential biological safety hazards, poor long-acting antibacterial effect and the like in order to simultaneously improve antibacterial and nucleating properties in polylactic acid preparation in the prior art. The catalyst is prepared from N 'N-bis (3-aminopropyl) methylamine, ethyl oxalyl chloride, a monoamine derivative, a halogenated hydrocarbon derivative and other raw materials. The antibacterial nucleating agent can significantly improve the crystallization and antibacterial performance effects of polylactic acid, and the nucleating agent can be rapidly and conveniently mixed with polylactic acid through a melt blending method to prepare various polylactic acid products. The preparation method is simple, the raw materials are easy to obtain, the application field of polylactic acid products is widened, and the preparation method has a good industrial prospect.

The application belongs to the technical field of medicine synthesis, and particularly relates to an intermediate compound of edoxaban. The application takes 2-bromo-5-methyl-3a, 4, 5, 6, 7, 7a-hexahydrothiazolo[5, 4-c] pyridine as a starting material, and a lactam product is obtained by undergoing a carbonylation reaction with (3R, 4R)-3-amino-4-hydroxy-N, N-dimethylcyclohexane-1-carboxamide under the action of a catalyst, and the obtained lactam product undergoes a Mitsunobu reaction with N-(4-chlorophenyl) oxamide to obtain edoxaban. The preparation method of edoxaban provided by the application introduces a lactam by using a copper-catalyzed carbonylation reaction, and the whole synthesis method is simple in operation, high in reaction yield and purity; can effectively avoid the addition of n-butyllithium and low-temperature operation required by the carboxylation in the prior art, improve the operation safety, and has the advantages of mild use conditions, high conversion rate and simple operation.

The application discloses high-elasticity polyoxamide as well as a preparation method and application thereof, wherein the high-elasticity polyoxamide adopts polyether chains to provide a'soft segment', oxamide structures and six-membered rigid rings to provide a 'hard segment', forms a linear structure with soft and hard phase embedding, and gives the polyoxamide high elasticity; specifically, the high-elasticity polyoxamide contains polyether chain structure units and oxamide structure units shown in formula (I) in a molecular structure: wherein R' is a group containing a six-membered rigid ring. The fiber prepared by using the high-elasticity polyoxamide has high elongation at break, high breaking strength, high 200% stress and excellent elastic recovery rate.

The application provides a device and a method for producing oxamide, the device comprising: a reaction device; a gas-liquid separation device; a solid-liquid separation device; a drying device; a crude rectification tower; a methanol purification system; a washing condensation tower; and an alcohol-ester mixer. The application uses relatively high-level heat energy generated by an ammonolysis reaction for drying of oxamide powder, uses relatively low-level heat energy for reboiling of the crude rectification tower, introduces second alcohol-ammonia gas phase generated by the drying device into the crude rectification tower to fully utilize the heat energy, and uses adsorption or membrane separation for refining treatment of crude methanol obtained from the crude rectification tower, so that the ammonia content in refined methanol can be reduced to 1 ppm. The process technical solution provided by the application fully utilizes heat of the ammonolysis reaction and waste heat of the drying device, and uses adsorption or membrane separation for methanol refining, so that the production cost of oxamide can be significantly reduced. Furthermore, the solution provided by the application can produce high-purity methanol for sale or return to a dimethyl oxalate synthesis section.