17 results about "Benzoxazinones" patented technology

The present application relates to processes and intermediates used in the manufacture of polyfluorophenyl benzoxazinones.

The present invention refers to a method for controlling undesired vegetation at a plant cultivation site, the method comprising the steps of providing, at said site, a plant that comprises at least one nucleic acid comprising a nucleotide sequence encoding a wild-type or a mutated protoporphyrinogen oxidase (PPO) which is resistant or tolerant to a benzoxazinone-derivative herbicide by applying to said site an effective amount of said herbicide. The invention further refers to plants comprising wild-type or mutated PPO enzymes, and methods of obtaining such plants.

The present invention belongs to the technical field of chemical synthesis, and specifically discloses a class of quaternary carbon indandione tetrahydroquinoline spiro alkaloids and their preparation methods and applications in the preparation of antitumor drugs. 1-(phenylsulfonyl)-4-vinyl-1,4-dihydro-2H-benzo[d][1,3]oxazine-2-one and 1,3-indanedione are used as raw materials, Pd2(dba)3·CHCl3 is used as a catalyst, (R)-4-(tert-butyl)-2-(2-(diphenylphosphine)phenyl)-4,5-dihydrooxazole or BINAP is used as a ligand, under nitrogen protection, in a reaction solvent, react at room temperature for 2 to 36 hours to obtain a target compound. The method of the present invention is simple to operate and has a high yield. The compound of the present invention has significant inhibitory activity on the proliferation of tumor cells A549, HELA, and MDA-MB-231, and can be used to prepare drugs for the prevention and treatment of tumor diseases.

This invention provides a method for preparing 2,2'-(1,4-phenylene)bis-4H-3,1-benzoxazin-4-one, relating to the field of compounds. The preparation method of this invention includes the following steps: (1) reacting anthranilic acid with terephthaloyl chloride in an organic solvent to generate intermediate A; (2) centrifuging the reaction product of step (1) to separate the wet crystalline intermediate A and the centrifugal mother liquor; (3) performing a cyclization reaction between the wet crystalline intermediate A from step (2) and acetic anhydride; (4) centrifuging, washing, and drying the reaction product of step (3) to obtain the target 2,2'-(1,4-phenylene)bis-4H-3,1-benzoxazin-4-one product. This invention prepares 2,2'-(1,4-phenylene)bis-4H-3,1-benzoxazin-4-one with not only low yellowness values ​​and high purity, but also high yield. The preparation method of the present invention has significant industrial value, and is particularly applicable to the field of polymer material additives where strict requirements are placed on product purity and yellowness.

Synergistic stabilizer compositions having a stabilizing amount of a co-synergist; optionally a stabilizing amount of a co-active agent; a stabilizing amount of an ultraviolet light absorber selected from an ortho-hydroxyphenyl triazines, ortho-hydroxy benzophenones, oxanilides, cyanoacrylates, benzoxazinones, optionally ortho-hydroxyphenyl benzotriazoles, and combinations thereof; and a stabilizing amount of a hindered amine light stabilizer, are provided herein. The total weight of co-synergist (IV) and co-active agent (when present) is from 1 wt. % to 99 wt. %, based on the total weight of the stabilizer composition; and the weight ratio of co-synergist to co-active agent (when present) is 1:99 to 99:1. Also disclosed are masterbatch concentrates, stabilized polymer compositions, and stabilized articles of manufacture, all containing the stabilizer composition.

The invention discloses a crystal of a benzoxazinone compound and a preparation method of the crystal, and particularly discloses a compound shown as a formula (I) and a preparation method and application of the crystal of the compound. # imgabs0 #

This invention discloses a highly efficient selective UV-absorbing film based on polyvinyl acetal and its preparation method, belonging to the technical field of polymer functional membrane materials. The UV-absorbing film comprises the following components in parts by weight: 55-95 parts of matrix resin, 5-45 parts of plasticizer, 0.005-1.2 parts of core UV absorber, 0.01-0.3 parts of auxiliary UV absorber, 0.01-0.8 parts of composite antioxidant, 0.01-0.8 parts of light stabilizer, and 0.0025-0.0065 parts of metal ion additive. The core UV absorber is an alkyl-modified benzoxazinone compound, and the composite antioxidant is a combination of a hindered phenolic resin as the main antioxidant and a thiophosphate ester as the auxiliary antioxidant. This invention achieves highly efficient blocking of UV-B radiation and high transmittance of UV-A radiation. Simultaneously, the film material has advantages such as low initial yellowing, excellent long-term anti-yellowing performance, good thermal stability, good compatibility with the matrix, and no exudation. The present invention also provides a method for preparing the core UV absorber and a method for preparing the membrane, which are simple processes and suitable for industrial production.

The invention discloses a method for synthesizing a chiral dihydrobenzoxazinone derivative through manganese-catalyzed bionic asymmetric hydrogenation. A catalytic system used in the method is high-yield metal manganese, phenanthridine, chiral phosphoric acid and a # imgabs0 # molecular sieve. The reaction can be carried out under the following conditions: the temperature is 25-50 DEG C; the solvent is dichloromethane; the pressure ranges from 200 psi to 1200 psi; the ratio of the substrate to the catalyst (phenanthridine, manganese and chiral phosphoric acid) is 100 / 10 / 5 / l; the catalyst is pentacarbonyl manganese bromide, phenanthridine and chiral phosphoric acid. According to the method for obtaining the corresponding chiral hydrogenated benzoxazinone derivative through hydrogenation of benzoxazinone, the enantiomeric excess can reach 95%. The method has the advantages of simple and practical operation, easily available raw materials, high enantioselectivity, good yield, green atom economy, environmental friendliness and the like.

The present invention relates to protoporphyrinogen oxidase inhibitors of the general formula (I)where the variables are defined herein. The invention features processes and intermediates for preparing the benzoxazinones of formula (I), compositions comprising them, and their use as herbicides—i.e. for controlling harmful plants. The invention also features methods for controlling unwanted vegetation comprising allowing an herbicidal effective amount of at least one benzoxazinone of formula (I) to act on plants, their seed, and / or their habitat.

The present disclosure relates to fused bicyclic compounds containing a ring core such as 2H-benzo[e][1,3]oxazin-4(3H)-one, 2,3-dihydrothieno[2,3-e][1,3]oxazin-4-one and 2,3-dihydrothieno[3,2-e][1,3]oxazin-4-one, which act as allosteric inhibitors of epidermal growth factor receptor (EGFR); pharmaceutical compositions comprising the compounds, optionally in combination with a second active agent, and methods of treating or preventing kinase-mediated disorders including cancer and other proliferative diseases.

The present invention refers to a method for controlling undesired vegetation at a plant cultivation site, the method comprising the steps of providing, at said site, a plant that comprises at least one nucleic acid comprising a nucleotide sequence encoding a wild-type or a mutated protoporphyrinogen oxidase (PPO) which is resistant or tolerant to a benzoxazinone-derivative herbicide by applying to said site an effective amount of said herbicide. The invention further refers to plants comprising wild-type or mutated PPO enzymes, and methods of obtaining such plants.

The present application relates to processes and intermediates used in the manufacture of polyfluorophenyl benzoxazinones, as protoporphyrinogen oxidase (PPO) inhibitor herbicides. The benzoxazinone herbicide having a phenyl ring at the benzoxazinone 6-position and the phenyl ring is further substituted with 5 fluorine atoms.

The invention relates to a herbicide, in particular to a synthesis method of flumioxazin, which comprises the following steps: carrying out hydrogenation reduction reaction on 7-fluoro-6-nitro-1, 4-benzoxazine-3 (4H)-ketone in the presence of a solvent to generate 6-amino-7-fluoro-1, 4-benzoxazine-3 (4H)-ketone; then, the 6-amino-7-fluorine-4-propynyl-1, 4-benzoxazine-3 (4H)-ketone and a propynylation reagent are subjected to a propynylation reaction, and 6-amino-7-fluorine-4-propynyl-1, 4-benzoxazine-3 (4H)-ketone is generated; and carrying out amidation reaction on the flumioxazin and 3, 4, 5, 6-tetrahydrophthalic anhydride to generate the flumioxazin. The method provided by the invention is simple in post-treatment operation, convenient for industrial operation, low in three wastes, high in yield and few in impurities, and can effectively provide high-purity flumioxazin.

The present invention discloses a weather-resistant epoxy resin composite material and a preparation method thereof. The weather-resistant epoxy resin composite material is prepared from the following components in parts by weight: 800-1000 parts of bisphenol A type E-51 epoxy resin; 80-100 parts of diethylenetriamine; 90-120 parts of epoxypropane benzyl ether; 1-15 parts of antioxidant; 2-5 parts of 2,2'-(1,4-phenylene)bis-4H-3,1-benzoxazin-4-one; 2-5 parts of N-(2-ethylphenyl)-N'-(2-ethoxy-5-tert-butylphenyl)oxalyldiamine. In the present invention, 2,2'-(1,4-phenylene)bis-4H-3,1-benzoxazin-4-one and N-(2-ethylphenyl)-N'-(2-ethoxy-5-tert-butylphenyl)oxalyldiamine are added and used as a compound weather-resistant agent, which can greatly increase the weather resistance of bisphenol A type epoxy resin and at the same time maintain relatively excellent mechanical properties.

The present invention discloses a preparation method of 4H-benzo[d][1,3]oxazin-4-one compounds, comprising the following steps: mixing an acyl aniline compound or an aniline compound, a rhodium catalyst, an oxidant, and an additive in a molar ratio of 1:(0.001-0.1):(0.1-5):(0-2) with dichloroethane to make the molar concentration of the acyl aniline 0.05-0.5 M, and reacting at 50-120 °C for 12-30 h under a carbon monoxide gas atmosphere; separating and purifying to obtain the 4H-benzo[d][1,3]oxazin-4-one compound. The present invention has the characteristics of simplicity, high efficiency, and good functional group tolerance.