11 results about "Phenanthridine" patented technology

The application discloses a kind of covalent organic framework and its preparation method, application in protein renaturation, belong to composite functional material technical field.The covalent organic framework with the pore size of 1.2-6.5nm provided in the application is prepared by Schiff base reaction of aldehyde group monomer and phenanthridine amino monomer.The preparation method provided in the application: under the catalysis of acetic acid, aldehyde group monomer and amino phenanthridine monomer are dissolved in the mixed solution of mesitylene and 1, 4-dioxane and react, separate and collect, obtain the covalent organic framework.The covalent organic framework prepared in the application can limit the degree of freedom of denatured protein, reduce protein misfolding and aggregation, promote protein correct folding, and can stabilize the correct folding intermediate state through hydrophobic interaction and π-π conjugation interaction, and through the precise regulation of confined space and interface interaction, the complete renaturation of protein can be realized, at the same time, the renaturation of most denatured proteins can be realized, with wide universality.

This article relates to a method for preparing phenanthridine. The invention involves converting biphenyl isonitriles into polysubstituted phenanthridines and their derivatives under photocatalysis and blue light in an argon atmosphere, yielding molecules with stable structures and excellent chemical properties. The synthetic method utilizes inexpensive and readily available raw materials; the reaction requires only a photocatalyst, additives, and blue light, thus saving raw materials and reducing reaction costs. The entire reaction system is simple, the reaction conditions are mild, the required equipment is minimal, the experimental operation is straightforward, and the yield is moderate to high.

The application discloses a synthesis process of (-)-alpha-lycorane alkaloid and belongs to the technical field of organic synthesis chemistry. (2Z,4E)-7,7-diethoxy-3-hydroxyhepta-2,4-dienoic acid methyl ester and 3,4-methylenedioxy-beta-nitrostyrene are used as starting materials, and (-)-alpha-lycorane is obtained through catalytic asymmetric tandem Michael addition reaction, nitro reduction amination reaction, Boc amidation reaction, Bischler-Napieralski cyclization reaction, ketone enolization tandem esterification reaction, enol triflate reductive hydrogenolysis reaction and amide reduction reaction in sequence. (-)-Alpha-lycorane has a four-membered ring core skeleton of pyrrole-phenanthridine ring, has good in-vitro tumor inhibition activity and cell proliferation growth inhibition activity. The synthesis process can realize efficient, simple and full synthesis of (-)-alpha-lycorane.

This invention discloses a method for synthesizing 6-arylphenanthrene diphenyl compounds. The method involves a dehydrazine radical tandem addition-cyclization reaction of 2-isocyanuric biphenyl and arylhydrazine under air atmosphere and blue visible light irradiation, catalyzed by a molybdenum sulfide / N-hydroxyphthalimide synergistic catalytic system, to generate 6-arylphenanthrene diphenyl compounds. This method has the advantages of readily available raw materials, simple operation, mild reaction conditions, high reaction selectivity and yield, and excellent substrate functional group compatibility.

The application discloses an ionic COF catalyst, a preparation method thereof and application of the catalyst in photocatalytic production of hydrogen peroxide. The catalyst is prepared from 2,4,6-triformylphloroglucinol and a phenanthridine monomer containing a double amino group through Schiff base condensation reaction under catalysis of acetic acid in a mixed solvent, and has an ionic covalent organic framework structure connected with beta-ketoenamine. The catalyst prepared by the application has irregular sheet-like agglomeration, a layered porous structure, a high specific surface area and a controllable ionic microenvironment, and can simultaneously strengthen oxygen adsorption activation and photogenerated carrier separation efficiency. When the catalyst is applied to photocatalytic production of hydrogen peroxide, efficient production of hydrogen peroxide can be realized under the conditions of pure water, visible light and no sacrificial agent, and the yield can reach 457 μM h ‑1 The application provides a green, mild and sustainable new solution to solve the problems of high energy consumption and high pollution of the traditional anthraquinone method and the bottleneck problem of the existing COF photocatalytic performance.

The invention relates to an ion-controllable COF catalyst, a preparation method and application of the ion-controllable COF catalyst in photocatalytic hydrogen production. The method comprises the following steps: step 1, mixing trialdehyde phloroglucinol with an amino-containing phenanthridine bromine salt, carrying out degassing treatment in the presence of a catalyst and a mixed solvent, and sealing; step 2, carrying out solvothermal reaction under a heating condition to obtain a precursor COF-Br containing bromide ions; step 3, the precursor COF-Br is subjected to washing, purification and drying treatment; and 4, dispersing the dried precursor COF-Br in a salt solution containing target anions to carry out ion exchange reaction, and carrying out solid-liquid separation and drying to obtain the ion-controllable COF catalyst. According to the method, a COF precursor containing a cation skeleton is constructed, and specific anions are introduced by utilizing an ion exchange technology, so that the compounding of photo-induced electrons and holes is effectively inhibited, and the photocatalytic hydrogen production efficiency is remarkably improved.

The invention relates to a hybridoma cell strain capable of secreting an azamiphenanthridine monoclonal antibody and application of the hybridoma cell strain, and belongs to the technical field of safe immunodetection. The hybridoma cell strain is preserved in China General Microbiological Culture Collection Center (CGMCC) on November 12, 2025, the preservation address is No.3, No.1 Yard, Beichen West Road, Chaoyang District, Beijing, and the preservation number is CGMCC No.46743. The azaphenanthridine monoclonal antibody disclosed by the invention is secreted by the hybridoma cell strain, and the monoclonal antibody secreted by the hybridoma cell strain has better detection sensitivity (IC50 value is 0.529 ng / mL) to azaphenanthridine, and can be used for residue detection of azaphenanthridine.

This invention relates to a visible light-mediated method for preparing hydroxyalkyl-substituted phenanthridine derivatives from biphenyl isonitriles and furans via free radical coupling cyclization. Under the influence of a photocatalyst and blue light radiation in an argon atmosphere, this invention achieves a technical solution for synthesizing structurally diverse hydroxyalkyl-substituted phenanthridine compounds from biphenyl isonitriles and furans, resulting in stable molecular structures and excellent chemical properties. The synthetic method utilizes inexpensive and readily available reactants, requiring only a photocatalyst, additives, and blue light, thus saving raw materials and reducing reaction costs. The reaction system is simple, the reaction conditions are mild, the required equipment is minimal, the experimental operation is simple, and the atom economy is high, with excellent yields. The method for synthesizing hydroxyalkyl-substituted phenanthridine derivatives of this invention can be applied to multiple industrial production fields, including pharmaceuticals, pesticides, and organic functional materials.

The application discloses a phenanthridine ketone derivative which is composed of aromatic carboxylic acid, o-halogenated aniline, ruthenium catalyst, ligand, alkaline compound, additive and organic solvent, and a structural formula is shown as follows, wherein Ar 1 comprises various alkyl, aryl, trifluoromethyl, methoxy, thiomethyl, acetyl, fluorine, chlorine or bromine substituted groups; Ar 2 comprises various alkyl, trifluoromethyl, fluorine, chlorine, bromine substituted groups; R comprises alkyl, aryl or hydrogen; the application further discloses a synthesis method of the phenanthridine ketone derivative. The method of the application takes aromatic carboxylic acid and o-halogenated aniline as raw materials, takes commercially available metal ruthenium as a catalyst, and takes phosphine compound as a ligand, and the product has the characteristics of extremely high regioselectivity, wide substrate applicability, and the like, the raw materials / catalyst are cheap and easy to obtain, the operation is simple, the atomic economy is high, and the yield is high.

The application discloses a kind of benzo phenanthridine ketone derivatives and modular synthesis method and application in preparation anticancer drug, belong to the technical field of organic chemistry and pharmaceutical chemistry technology cross technology.This application uses cobalt / copper composite catalytic system, by two-step carbon hydrogen bond activation strategy, first realizes halogen retention carbon hydrogen bond activation cyclization reaction, further utilizes the halogen site of retention and carries out modular derivative modification, and quickly constructs a variety of substituted benzo phenanthridine ketone derivative library.The method significantly improves the synthesis efficiency and atom economy, provides efficient, flexible and reliable path for the construction of benzo phenanthridine alkaloid derivatives.The obtained derivative shows good activity in anti-hepatocarcinoma Huh-7 cell activity screening, and the activity of compound 47 is better (IC50=39.4 μM), which provides a new active molecular skeleton and potential target for the development of hepatocarcinoma treatment drugs.