111 results about "Phenanthridine" patented technology

The invention discloses a preparation method for a phenanthridine derivative. The preparation method comprises the following steps of: adding a catalyst, an oxidant, acid, a 2-phenylaniline compound and an olefin compound into organic solvent; after reaction, carrying out post treatment to obtain the phenanthridine derivative, wherein the catalyst is a bivalent palladium catalyst. According to the preparation method for the phenanthridine derivative disclosed by the invention, the adoption of reagents with high toxicity and high corrosiveness is avoided. The preparation method has the advantages of environment friendliness, easiness in operation, higher yield and simplicity and convenience in post treatment. In addition, a substrate obtained by the method is strong in designability and can be used for designing to synthesize a compound with the required structure according to actual requirements, and thus stronger practicability is realized.

The present invention provides compounds of formula I: formula (I) wherein X¹-X⁴ and R¹-R¹² have any of the values defined in the specification, as well as salts and prodrugs thereof, which inhibit major molecular mechanisms associated with bacterial cell division and proliferation so as to be useful for the treatment and/or prevention of bacterial infections. The invention also provides compositions comprising these compounds as well as methods for using these compounds to inhibit bacterial cell division and proliferation and to treat bacterial infections.

A substance that facilitates hole injection and has high triplet excitation energy is provided. A light-emitting element having high emission efficiency is provided. A light-emitting element driven with a low voltage is provided. Or a light-emitting element having a long lifetime is provided. Provided is a light-emitting element including a triazolo[4,3-f]phenanthridine derivative or a triazolo[3,4-a]isoquinoline derivative. Provided is a triazolo[4,3-f]phenanthridine and triazolo[3,4-a]isoquinoline derivatives, which are novel and can be used for the light-emitting element.

The invention provides a phenanthridine compound with an effect of resisting hepatitis B and hepatitis C, a medicinal composition taking the same as an active medicine component, a preparation method and applications of the phenanthridine compound in preparing a medicine for resisting hepatitis C viruses, and preparing an anti-virus medicine. According to the invention, the activity of benzylphenethylamine alkaloid in resisting various viruses is discovered in a process of studying a plant anti-virus natural product, and an obvious effect in resisting viruses of hepatitis B and hepatitis C of a phenanthridine derivative is discovered through structure modification, structure-function relationship and structure optimization.

New classes of heterocyclic aromatic cationic compounds are disclosed, and in particular new classes of phenanthridinium derivatives, most notably dihydro-imidazo-phenanthridinium (DIP) compounds. These findings are based on the reaction of the middle b ring of a phenanthridinium core with primary amines to form DIP compounds (Formula A) or secondary amines to form 2-aminoalkyl phenanthridinium derivatives (Formula B). These reactions can also be applied to other classes of starting compounds which comprise a 6-membered ring aromatic heterocycle having a ring nitrogen and at least one alpha hydrogen atom which can be reacted with a primary or secondary amine.

This invention relates to compounds, pharmaceutical compositions, and methods of using the disclosed compounds for inhibiting PARP.

The invention relates to a method for catalytically preparing 6(5H)-phenanthridine ketone by a copper component. The method comprises the step of catalyzing a 2-phenyl benzamide derivative to carry out N-arylated reaction to generate a 6(5H)-phenanthridine ketone derivative by the copper component under the coordination of a ligand in an air environment or airtight environment. The method can be carried out in the air environment, and the catalyst used is simple and easy to obtain and high in reaction yield. The method provided by the invention is beneficial for industrial production.

The invention discloses a dinuclear ring metal platinum (II) complex near-infrared electrophosphorescent material containing different conjugated bridges, and application of the electrophosphorescent material to an organic electroluminescent diode. The dinuclear ring metal platinum complex near-infrared electrophosphorescent material uses different conjugated rigid structures (benzene, 1,4-difluorobenzene, carbazole, fluorene and pyrene) as luminous kernel donor (D) units, and uses nitrogen-containing dentate conjugate ligands (isoquinoline, anthraquinoline and phenanthridine) as receptor (A) units for building the ring metal platinum complex near-infrared electrophosphorescent material using A-D-A structure as a main ligand, using 2,2,6,6-tetramethyl-3,5-heptadione as an auxiliary ligand and using platinum ions. The organic electrophosphorescent luminous device is prepared by using the near-infrared electrophosphorescent material as a luminous layer doping agent and using m-MTDATA:CBP as a body material. The device is a near-infrared electrophosphorescent luminous device with the maximum emitting peak being 709nm, the outer quantum efficiency being 3.97 percent and the maximum radiation degree being 2354nW.Sr<-1>.cm<-2>.

Imidazophenanthridine ligands and metal complexes are provided. The compounds exhibit improved stability through a linking substitution that links a nitrogen bonded carbon of an imidizole ring to a carbon on the adjacent fused aryl ring. The compounds may be used in organic light emitting devices, particularly as emissive dopants, providing devices with improved efficiency, stability, and manufacturing. In particular, the compounds provided herein may be used in blue devices having high efficiency.

The invention provides an organic electroluminescent compound, an organic electroluminescence device and application thereof. The structure of the organic electroluminescent compound is described in the description, wherein R1 and R4 are respectively independent hydrogen, heavy hydrogen, linear or branched chain alkyls of C1-C20, and or one of phenyl, anilino, diphenylamino, 2-phenyl-3-amino-pyridyl, 3-amino-dipyridyl, 2-phenyl-1-naphthylamine, 2-amino-dinaphthyl, 2-phenyl-1-amino-phenanthryl, 3-amino-diphenanthryl, 2-phenyl-1-amino-anthranyl, 2-amino-dianthranyl, phenanthridinyl, biphenyl, pyridyl, pyrimidinyl or triazinyl; R2 and R3 are respectively independent hydrogen, heavy hydrogen, linear or branched chain alkyls of C1-C20, or phenyl, pyridyl, naphthyl, phenanthryl, anthryl, phenanthridine, biphenyl, pyridyl, pyrimidinyl and triazinyl; l, m, n and o are integers of 0-4.

The invention discloses organic semiconductor materials containing 2,9-dialkyl-6-alkoxy phenanthridine and a preparation method and an application thereof. The organic semiconductor materials are prepared by carrying out a reaction of 2,9-dialkyl-6-alkoxy phenanthridine halogenated derivatives and a monomer containing an aromatic group structure under a metal catalyst, wherein the aromatic group and a 2,9-dialkyl-6-alkoxy phenanthridine unit are connected in a conjugate manner. The invention discloses a method for synthesis of 2,9-dialkyl-6-alkoxy phenanthridine by a phenanthridone isomerization reaction; a series of organic semiconductor materials containing the 2,9-dialkyl-6-alkoxy phenanthridine unit are synthesized and are applied in the field of organic optoelectronic devices, and solar cell devices with high open circuit voltage and deep blue polymer blue light devices are obtained.

The invention relates to a method for preparing 6-cyano phenanthridine and derivatives thereof. The method comprises the steps of adding an azido-terminal-substituted olefin compound represented by aformula I shown in the description, a nitrogen source, a catalyst, an oxidant and an organic solvent into a pressure-proof reactor, carrying out a full reaction at the temperature of 30 DEG C to 60 DEG C, and subjecting a reaction solution to separation and purification, thereby obtaining the 6-cyano phenanthridine represented by a formula II shown in the description and the derivatives thereof, wherein the nitrogen source comprises sodium azide, the catalyst comprises copper powder, cuprous bromide, copper sulfate, copper chloride, copper acetate or cuprous oxide, R1 and R2 in the formulae Iand II are separately the same, R1 is H, F or Cl, R2 is H, or H is monosubstituted or polysubstituted by methyl, chlorine, fluorine, phenyl, tert-butyl or methoxy. Compared with the prior art, the method has the advantages that the method is safe and environmentally friendly, no waste gas and waste water is produced, the substrate adaptability is good, all kinds of substituents can be aromatized/cyanated, the reaction conditions are mild, and the reaction steps are simple.

The invention discloses a preparation method of 6-H-phenanthridine compounds by a one-pot process, which comprises the following steps: adding reactants N-protected arylamine and bromobenzyl bromide compounds into a solvent, adding a metal palladium catalyst, a ligand and an alkali, carrying out chemical reaction under heating and inert gas protective conditions, and after the reaction finishes, carrying out after-treatment to obtain the compound pure products. By using the simple accessible N-protected arylamine and the commercial accessible bromobenzyl bromide compounds as the raw materials, one-pot three-step cascade reaction is performed to obtain the 6-H-phenanthridine compounds. The method is simple to operate, and has the characteristics of simple after-treatment, higher yield and the like.

The invention discloses a synthesis method of phenanthridine as shown in a formula (I) and a derivative of the phenanthridine. In the synthesis method, o-arylphenylsulfimide shown as a formula (II) isused as a raw material and reacts in an organic solvent under the action of a [Cu]/Selectfluor catalyst to obtain a corresponding target product (I). The synthesis method disclosed by the invention has the advantages of cheap and easily available and low-toxicity catalyst, environmental friendliness, mild reaction conditions, high universality of functional group and easiness and convenience in operation. The formulas (I) and (II) are shown in the description.

The invention discloses a synthesis method of a 6-substituted phenanthridine compound represented by a formula (I), wherein a N-[1-phenyl-1'-biphenyl]benzenesulfonamide compound represented by a formula (II) is used as a raw materials and is subjected to a reaction in an organic solvent under the action of a [Fe]/Selectfluor catalyst to prepare a corresponding target product represented by the formula (I). According to the present invention, the synthesis method has advantages of environmental friendliness, mild reaction conditions, good functional group popularity, easy operation and the like, and uses the catalyst with advantages of low cost, easy availability and low toxicity. The formulas (I) and (II) are defined in the specification.

The invention discloses a method for continuously preparing a dihydrobenzo [j] phenanthridine compound containing a trifluoromethyl functional group by using a micro-channel reaction device, which comprises the following steps: (1) dissolving a 1,7-eneyne compound and alkali in a proper solvent to obtain a material I; (2) dissolving a trifluoromethyl reagent and a photocatalyst in a proper solventto obtain a material II; (3) respectively pumping the material I and the material II into a micro-channel reaction device, fully mixing, and carrying out a photocatalytic trifluoromethylation reaction to obtain a reaction solution; and (4) quenching the reaction liquid, adding a corresponding organic solvent for extraction, collecting an organic phase, drying, concentrating and recrystallizing toobtain a target product. The micro-channel reaction device is used for preparing the 1,7-eneyne trifluoromethylation product, the reaction conditions are milder, the reaction rate can be effectivelycontrolled, the reaction time is shortened, continuous production is achieved, side reactions are reduced, the maximum product yield can reach 99.3%, the amplification effect is basically avoided, andindustrial amplification is facilitated.

Pseudobase benzo[c]phenanthridines and the pharmaceutically acceptable salts thereof of Formula I

are provided herein. The variables R, R₁, R₂, R₃, and R⁴ are defined herein. Certain pseudobase benzo[c]phenanthridines provided herein act as prodrugs, targeting the parent benzo[c]phenanthridinium alkaloid to hydrophilic or hydrophobic regions in the body. Pharmaceutical compositions comprising a pseudobase benzo[c]phenanthridine and a carrier, excipient, or diluent are provided herein. Methods of treating or preventing microbial, fungal and or viral infections and methods of treating diseases and disorders responsive to protein kinase C modulation, topoisomerase I, and/or topoisomerase II modulation are also provided.

The invention discloses a synthetic method for a (1,2,3-triazolyl)[1, 5-f]phenanthridine-10-ethyl carboxylate compound, belonging to the technical field of organic synthesis. According to main points of a technical scheme in the invention, a reaction equation in the synthesis process of the method is as described in the specification. The method is mild in reaction conditions and simple in process; starting raw materials are noncyclic compounds like iodomethane, 4-azidoethyl acetoacetate, alkyne-terminated compounds and 1,2-allenyl ketones which are convenient to prepare or easy to purchase; the synthetic method can simultaneously construct three rings in a phenanthridine ring; and the finally synthesized compound is easy to separate and purify.

The invention discloses an environment-friendly synthetic method of a 6(5H)-phenanthridine derivative. The method specifically comprises the step of carrying out catalyzed oxidation by virtue of metalcobalt, so as to realize the high-selectivity and high-yield preparation of the 6(5H)-phenanthridine derivative, wherein N-([1,1'-biphenyl]-2-yl)pyridine amide is take as the raw material, azodiformate is taken as a carbonyl source for replacing poisonous and harmful carbon monoxide, and oxygen is taken as an oxidant. The environment-friendly synthetic method has the characteristics that the rawmaterial is easily available, the operation is simple and convenient, the chemical selectivity and the regional selectivity are high, and the like; and the environment-friendly synthetic method has relatively high implement values and social and economic values.

The invention discloses a phenanthridine compound and a synthesis method thereof. An aromatic amine compound and a diazocarbonyl compound are added into a solvent, reacting is carried out in an oxygenenvironment, and then separating and purifying are carried out to obtain the phenanthridine compound. The invention provides the method for synthesizing the phenanthridine compound by taking the aromatic amine and the diazocarbonyl compound as raw materials for the first time. The method is simple and efficient, does not need metal catalysts, and has wide applicability of substrates.