4 results about "Phenanthridine" patented technology

The application discloses an ionic COF catalyst, a preparation method thereof and application of the catalyst in photocatalytic production of hydrogen peroxide. The catalyst is prepared from 2,4,6-triformylphloroglucinol and a phenanthridine monomer containing a double amino group through Schiff base condensation reaction under catalysis of acetic acid in a mixed solvent, and has an ionic covalent organic framework structure connected with beta-ketoenamine. The catalyst prepared by the application has irregular sheet-like agglomeration, a layered porous structure, a high specific surface area and a controllable ionic microenvironment, and can simultaneously strengthen oxygen adsorption activation and photogenerated carrier separation efficiency. When the catalyst is applied to photocatalytic production of hydrogen peroxide, efficient production of hydrogen peroxide can be realized under the conditions of pure water, visible light and no sacrificial agent, and the yield can reach 457 μM h ‑1 The application provides a green, mild and sustainable new solution to solve the problems of high energy consumption and high pollution of the traditional anthraquinone method and the bottleneck problem of the existing COF photocatalytic performance.

The application discloses a phenanthridine ketone derivative which is composed of aromatic carboxylic acid, o-halogenated aniline, ruthenium catalyst, ligand, alkaline compound, additive and organic solvent, and a structural formula is shown as follows, wherein Ar 1 comprises various alkyl, aryl, trifluoromethyl, methoxy, thiomethyl, acetyl, fluorine, chlorine or bromine substituted groups; Ar 2 comprises various alkyl, trifluoromethyl, fluorine, chlorine, bromine substituted groups; R comprises alkyl, aryl or hydrogen; the application further discloses a synthesis method of the phenanthridine ketone derivative. The method of the application takes aromatic carboxylic acid and o-halogenated aniline as raw materials, takes commercially available metal ruthenium as a catalyst, and takes phosphine compound as a ligand, and the product has the characteristics of extremely high regioselectivity, wide substrate applicability, and the like, the raw materials / catalyst are cheap and easy to obtain, the operation is simple, the atomic economy is high, and the yield is high.

The application discloses a kind of benzo phenanthridine ketone derivatives and modular synthesis method and application in preparation anticancer drug, belong to the technical field of organic chemistry and pharmaceutical chemistry technology cross technology.This application uses cobalt / copper composite catalytic system, by two-step carbon hydrogen bond activation strategy, first realizes halogen retention carbon hydrogen bond activation cyclization reaction, further utilizes the halogen site of retention and carries out modular derivative modification, and quickly constructs a variety of substituted benzo phenanthridine ketone derivative library.The method significantly improves the synthesis efficiency and atom economy, provides efficient, flexible and reliable path for the construction of benzo phenanthridine alkaloid derivatives.The obtained derivative shows good activity in anti-hepatocarcinoma Huh-7 cell activity screening, and the activity of compound 47 is better (IC50=39.4 μM), which provides a new active molecular skeleton and potential target for the development of hepatocarcinoma treatment drugs.