118 results about "Indolizine" patented technology

The invention discloses the preparation method of 7-ethyl-10-hydroxycamptothecin from 4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione and 1-(2-amino-5 -hydroxyphenyl)-propan-1-one using higher reaction temperature and faster heating to that temperature.

The invention provides a simple preparation method of a 3-aryl indolizine derivative. The method comprises the following step of: reacting N-benzylpyridine onium salt directly prepared from a pyridine derivative and benzyl halide with electron-deficient alkyne under the existence of alkali to prepare the 3-aryl indolizine derivative. All raw materials used in the simple preparation method can be directly purchased, and are relatively low in price and easy to obtain; any catalyst, ligand and oxidant do not need to be used in the process flow, the process flow is simple, and the cost is obviously reduced; the problem that transition metal in target products exceeds standards is avoided; the whole process is insensitive to air or moisture, and the normal operation can be carried out under loose reaction conditions without polluting the environment; and the simple preparation method can be used for providing the 3-aryl indolizine derivative with abundant sources and low price for the preparation of related products in the fields of biology, pesticides and medicine.

The invention discloses a purrocoline derivative and a synthetic method and application thereof. The purrocoline derivative with a novel structure can be prepared by reacting propargyl alcohol and a 2-alkyl pyridine compound by taking samarium trifluoromethanesulfonate as a catalyst under the condition without a solvent; the reaction consumption and the chemical contamination are reduced, the cost is reduced and the operation is simplified; the obtained purrocoline derivative has better activity on a gastric cancer cell strain MGC80-3. The structural formula of the purrocoline derivative is shown in a formula (I) in the specification, wherein R<1> is phenyl, 4-methoxyphenyl, 4-fluorophenyl and 2-chlorphenyl or thienyl, R<2> is phenyl, and R<3> is H, phenyl, methyl, a nitrile group or an ethyl acetate group.

The invention discloses an acidification corrosion inhibitor based on an interpolymer indolizine derivative as well as a preparation method and application thereof. The acidification corrosion inhibitor contains the interpolymer indolizine derivative; the interpolymer indolizine derivative is prepared by carrying out decarboxylation on heterocyclic alkali including (substituted) quinoline, (substituted) pyridine and the like, and carboxymethyl heterocyclic alkali quaternary ammonium salt obtained by alpha-haloacetic acid, and then carrying out intermolecular addition polymerization reaction onquaternary ammonium salt of the heterocyclic alkali including the (substituted) quinoline, the (substituted) pyridine and the like. The acidification corrosion inhibitor disclosed by the invention has relatively good corrosion inhibition performance under the condition that common corrosion inhibition synergists including alkynol and the like do not need to be compounded; the use amount of the acidification corrosion inhibitor is less and the acidification corrosion inhibitor can reach, even be better than the requirements of an acidification corrosion inhibitor performance testing method andfirst-grade to third-grade standards in evaluation indexes SY / T 5405-1996 when being independently used.

The invention relates to a crosslinkable organic molecule having a structure of the formula (1) and to the use thereof, wherein Ar is independently of one another, an unsaturated or aromatic carbo- or heterocyclic unit with 5 to 30 ring atoms, selected from the group consisting of naphthalene, anthracene, phenanthrene, pyrene, dihydropyrene, chrysene, perylene, fluoranthene, benzanthracene, tetracene, pentacene, benzpyrene, furan, benzofuran, isobenzofuran, thiophene, benzothiophene, isobenzothiophene, dibenzothiophene, pyrrole, indole, isoindole, carbazole, pyridine, quinoline, isoquinoline, acridine, phenanthridine, benzo-5,6-quinoline, benzo-6,7-quinoline, benzo-7,8-quinoline, phenothiazine, phenoxazine, pyrazole, indazole, imidazole, benzimidazol, naphthimidazole, phenanthrimidazole, pyridimidazole, pyrazine-imidazole, quinoxalinimidazole, oxazole, benzoxazole, naphthoxazole, anthroxazole, phenanthroxazole, isoxazole, isothiazole, 1,3-thiazole, benzothiazole, pyridazine, benzopyridazine, pyrimidine, benzpyrimidine, quinoxaline, pyrazine, phenazine, naphthyridine, azacarbazole, benzocarboline, phenanthroline, 1,2,3-triazole, 1,2,4-triazole, benzotriazole, 1,2,3-oxadiazole, 1,2,4-oxadiazole, 1,2,5-oxadiazole, 1,3,4-oxadiazole, 1,2,3-thiadiazole, 1,2,4-thiadiazole, 1,2,5-thiadiazole, 1,3,4-thiadiazole, 1,3,5-triazine, 1,2,4-triazine, 1,2,3-triazine, tetrazole, 1,2,3,4- oxatriazole, 1,2,3,4-oxatriazole, 1,2,4,5-tetrazine, 1,2,3,4-tetrazine, 1,2,3,5-tetrazin, purine, pteridine, indolizine, benzothiadiazole, indenocarbazole, indenofluorene, spirobifluorene, and indolocarbazole; D1 is a donor group having a structure of the formula (1a); and D2 is a donor group having a structure of the formula (1b).

The invention discloses a preparation method of a 3-alkyl indolizine derivative. The method comprises the steps that N-alkyl pyridinium salt directedly prepared from a pyridine derivative and primary halogenated hydrocarbon is reacted with electron-poor alkene in the presence of alkali and 2,2,6,6-tetramethylpiperidinooxy (TEMPO), and the 3-alkyl indolizine derivative is prepared. The preparation method aims to develop the brand new preparation raw materials of the 3-alkyl indolizine derivative and the corresponding technology method so as to simply and easily synthesize the 3-alkyl indolizine derivative in an environmentally friendly mode at the low production cost under loose reaction conditions.

The invention relates to a pH-responsive fluorescent molecular probe with a chemical name, namely, 5-(2-phenyl-pyrrolo[2,1,5-cd]indolizine-5-yl)-1,3,4-oxadiazole-2-thiophenol, as well as a preparation method and application thereof. According to the preparation method, a mercapto group is adopted as an identifying group and an indolizine group is adopted as a signal group for the first time to successfully prepare the compound. By virtue of the fluorescent probe molecules, a sensitive identification of H<+1> under different pH values is realized, the types of the pH-responsive fluorescent molecular probe are enriched, and a novel use of the mercapto functional group is opened up. The pH-responsive fluorescent molecular probe has very broad industrial application prospects and provides valuable reference to make a scientific research.

The invention belongs to the technical field of organic synthesis, in particular relates to a synthetic process of O-3-chloro-2-propenyl hydroxylamine. The synthetic process comprises the following steps of (1) successively adding phthalic acid and thionyl chloride into a reactor, performing a temperature rising reaction, distilling and removing excessive thionyl chloride to obtain o-phthaloyl chloride; (2) dissolving hydroxylamine hydrochloride into dichloromethane, dropwise adding the o-phthaloyl chloride, continually stirring and reacting after dropwise adding, distilling and removing the dichloromethane after reaction completion, so as to obtain N-hydroxyl phathalicimide; (3) dissolving the N-hydroxyl phathalicimide into a sodium hydroxide aqueous solution, dropwise adding trans-1,3-dichloropropene for reaction, after reaction completion, filtering to obtain 2-(3-chloroallyloxy)-isopropyl indolizine-1,3-dione; (4) adding the 2-(3-chloroallyloxy)-isopropyl indolizine-1,3-dione into a hydrochloric acid solution for hydrolysis, filtering, collecting organic phases, and the O-3-chloro-2-propenyl hydroxylamine is obtained. The synthetic process provided by the invention has the advantages that raw materials are low in price and easy to obtain, the reaction condition is mild and the yield is high.

The invention discloses a method for preparing a 3-aryl purrocoline derivative. The 3-aryl purrocoline derivative is prepared by arylboronic acid in the presence of a palladium catalyst based on oxygen as a final oxidant. The process comprises the following steps of: placing purrocoline substituted by hydrogen in site 3, arylboronic acid, the palladium catalyst, nitrogen-containing ligands or nitrogen-free ligands and alkaline components in a reactor utensil according to a molar ratio of 1:(1.0-3.0):(0.0125-0.10):(0.0125-0.30) or 0.0:(1.0-5.0); adding 2.0-20ml of solvent; heating and stirring under oxygen atmosphere to react; pouring a mixture after reaction to water; and filtering, washing and drying, and recrystalizing or performing column chromatography isolation to obtain the 3-aryl purrocoline derivative. The method provided by the invention is short in process flow, simple and accessible, and the nitrogen--containing ligands or nitrogen-free ligands which are not expensive can be selected. The final oxidant is oxygen in air which is green and environment-friendly, so that the reaction condition is loose, the preparation cost is lowered, and the 3-aryl purrocoline derivative in rich source can be provided for manufacturing related products in the field of biology, pesticides and medicines.

The present invention is directed to compounds of formula (I):described as novel indolizine derivatives and to a method for their preparation along with pharmaceutical compositions thereof whose substituents are as described in the specification.

The invention discloses an indolizine carboxylic acid pH fluorescent probe, the probe is 2-acetyl indolizine-7-carboxylic acid, and its chemical structural formula is shown in formula (1). The fluorescent probe of the present invention has unique fluorescence selectivity and higher sensitivity to pH in an aqueous solution of dimethyl sulfoxide. Compared with existing probes, it has a narrow pH corresponding range and is not subject to background interference. It is suitable for It has significant advantages such as pH detection in strongly acidic environments, and has great application prospects.

The invention relates to a pH-responsive fluorescent molecular probe with a chemical name, namely, 5-(2-phenyl-pyrrolo[2,1,5-cd]indolizine-5-yl)-1,3,4-oxadiazole-2-thiophenol, as well as a preparation method and application thereof. According to the preparation method, a mercapto group is adopted as an identifying group and an indolizine group is adopted as a signal group for the first time to successfully prepare the compound. By virtue of the fluorescent probe molecules, a sensitive identification of H<+1> under different pH values is realized, the types of the pH-responsive fluorescent molecular probe are enriched, and a novel use of the mercapto functional group is opened up. The pH-responsive fluorescent molecular probe has very broad industrial application prospects and provides valuable reference to make a scientific research.