22 results about "Indolizine" patented technology

The invention belongs to the technical field of organic synthesis and medicinal chemistry, and particularly relates to a synthesis method of a novel polycyclic aromatic hydrocarbon derivate 2, 6-di-tert-butyl pyrene and indolizine phenothiazine compound and application of the compound in the aspect of anti-cancer drugs. The synthesis process is simple and convenient, conditions are mild, and the yield is ideal. Pharmacodynamic evaluation shows that the compound shows strong inhibitory activity on various human cancer cell lines, and the IC50 values are respectively cervical cancer Hela cells (0.17 mu M), lung cancer A549 cells (0.3 mu M), prostatic cancer PC-3 cells (0.42 mu M) and liver cancer HepG2 cells (10.79 mu M), which are respectively reduced by 109 times, 173 times, 35 times and 1.8 times compared with positive control drug cis-platinum. In addition to efficiently inhibiting cancer cells, the compound has low toxicity to normal cells, meets the basic requirements of excellent anti-cancer drugs, and shows important application value and potential in the field of research and development of novel anti-cancer drugs.

The present invention addresses the problem of providing a crystal of a compound having EGFR-inhibiting ability or a salt thereof, the crystal having excellent stability (heat resistance, purity) and / or low hygroscopicity. One aspect of the present invention provides a crystalline form of (S)-N-(4-amino-6-methyl-5-(quinolin-3-yl)-8, 9-dihydropyrimido [5, 4-b] indolizine-8-yl) acrylamide having a peak in a powder X-ray diffraction pattern at a predetermined angle (diffraction angle 2 [theta] + / -0.2 DEG).

The invention discloses a high-breathability sponge foam material and a preparation method thereof, and belongs to the technical field of sponge material preparation, the high-breathability sponge foam material comprises the following components by weight: 100 parts of modified polyisocyanate, 150-200 parts of polyol, 10-50 parts of a first modified monomer, 4-18 parts of a second modified monomer, 2-5 parts of a foaming agent, 0.5-3 parts of silicone oil, and 0.5-2 parts of a catalyst; the first modified monomer is obtained by performing Knoevenagel condensation on diacetyl piperazine diketone and diethoxy benzaldehyde, then performing acylation with trifluoromethanesulfonic anhydride to form ester, then reacting with pyridine to generate pyridinium salt, performing ring formation to obtain ethoxy phenyl grafted pyrazino indolizine, and finally performing ether cracking; the second modified monomer is 2, 7-dihydroxy-9-fluorenone; on the basis of polyurethane, by introducing the first modified monomer and the second modified monomer, the high-breathability sponge foam material with good mechanical properties is prepared.

The present application provides a metallocene compound and a preparation method, a catalyst composition, a propylene homopolymerization method and an ethylene and alpha-olefin copolymerization method. The metallocene compound has a structure as shown in formula I. Formula I. The metallocene compound containing an indolizine and cyclopentadiene bridge of the present application is used as a main catalyst in combination with a cocatalyst for propylene homopolymerization, has high catalytic activity, can improve the copolymerization activity of propylene and ethylene, has high toughness and good elongation at break, and can improve the catalytic activity and monomer insertion rate in ethylene and alpha-olefin copolymerization.

The invention relates to the technical field of photovoltaic cells, in particular to a solar cell and a photovoltaic module. The solar cell includes: a perovskite active layer including a perovskite active material; and the interface modification layer is arranged on the surface of at least one side of the perovskite active layer along the thickness direction, and the material of the interface modification layer comprises a compound with a structure as shown in a formula (I). An interface modification layer containing a compound shown in a formula (I) is prepared on the surface of a perovskite active layer, and the synergistic effect of an indolizinone ring main nucleus, aromatic amino (-NH-Ar1) and aromatic sulfonyl (-SO2-Ar2) in the compound shown in the formula (I) is utilized, so that extraction and transmission of current carriers can be promoted, defects of the perovskite active layer can be passivated, ion migration can be inhibited, and the photoelectric conversion efficiency can be improved. And meanwhile, the formed interface modification layer has hydrophobicity, so that the photoelectric conversion efficiency and the long-term stability of the perovskite solar cell are improved.

The invention relates to a compound corresponding to formula (I): in which - R2 and R3 together form, with the carbon atoms of the phenyl nucleus to which they are attached, a 6-membered nitrogenous heterocycle corresponding to one of formula (A), (B) or (C) below: in which the wavy lines represent the phenyl nucleus to which R2 and R3 are attached. Preparation process and pharmaceutical composition comprising the said compound for the treatment and prevention of diseases requiring a modulation of b-FGFs.

The present application discloses a preparation method for synthesizing 3-substituted indolizine derivatives by electrochemical oxidation. The preparation method is obtained by reacting pyridine derivatives, acetophenone derivatives, maleic anhydride as reactants, nickel bromide as catalyst, 2,6-bis(4,5-dihydrooxazol-2-yl)pyridine as ligand, and N,N-dimethylacetamide (DMA) as solvent to obtain the target product. The reaction raw materials and solvents involved in the preparation method of the present application are all commercially available products with low prices; the reaction conditions are simple and mild, the yield is good, the atom utilization rate is high, it has the characteristics of green chemistry, and is in line with the concept of sustainable development.

The application discloses a preparation method of a medical intermediate (R)-7-ethyl camptothecin, and relates to the field of chemical medicine synthesis. The application comprises the following contents: (R)-4-ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione (formula A) and 1-(2-aminophenyl)propan-1-one (formula B) are used as main raw materials, a target compound (R)-7-ethyl camptothecin is obtained through reaction in an organic solvent under the action of a catalyst. The application provides a novel preparation method of the medical intermediate (R)-7-ethyl camptothecin, and the preparation method is simple, stable, high in yield, and suitable for industrial production.

The invention discloses a camptothecin derivative as well as a preparation method and application thereof. The camptothecin derivative has a general formula shown as a structural formula (I). Wherein R1 is one of hydrogen, amino, hydroxyl, methyl, methoxyl, nitryl, halogen and trifluoromethyl, R2 is one of hydrogen, methyl, ethyl and halogen, and R3 is one of hydrogen and acetyl. The preparation method comprises the following steps: carrying out condensation reaction on (S)-4-ethyl-4-hydroxy-7, 8-dihydro-1H-pyran O [3, 4-F] indolizine-3, 6, 10 (4H)-ketone and an o-aminobenzaldehyde / acetophenone derivative in N, N-dimethylformamide under the protection of nitrogen, and synthesizing a target compound through the catalysis of trimethylchlorosilane. The camptothecin derivative prepared by the invention has a remarkable antifungal effect, and tests prove that the camptothecin derivative has broad-spectrum inhibitory activity on various plant pathogenic fungi. According to the invention, the resistance limitation of the traditional bactericide is broken through, and an efficient and low-toxicity novel solution is provided for prevention and treatment of fungal diseases of agricultural and forestry crops.

The application belongs to the technical field of plastics, and particularly relates to a plastic particle performance detection process in an injection molding machine, which aims at the problem that existing detection data can only be obtained and material conditions in the detection process cannot be understood, and the following scheme is proposed, which comprises the following steps: S1: obtaining plastic particles, and then obtaining a marker material, the amount of the marker material being 0.2% to 1% of the amount of the plastic particles, and the marker material comprising fluorescent powder, indolizine, powdered rubber, ethylene glycol and paraffin wax; S2: pouring the plastic particles and the marker material into a stirring device for stirring, and performing fluorescent marking on the material of the plastic particles by the marker material, so that a fluorescent picture of the plastic particles is obtained in the performance detection process, the change of the plastic particles before and after the detection and in the detection process is understood by using the fluorescent picture, and the change of the material attached with the fluorescent is understood, and if the fluorescent gathers together or the fluorescent is unevenly distributed, it is indicated that the plastic particles are not uniformly stirred in the production process.

The invention belongs to the technical field of organic synthesis and medicinal chemistry, and discloses efficient synthesis of a novel polycyclic aromatic hydrocarbon derivative 5, 9-di-tert-butyl-12-mesitylene naphtho indolizine phenothiazine and an anti-cancer application of the novel polycyclic aromatic hydrocarbon derivative 5, 9-di-tert-butyl-12-mesitylene naphtho indolizine phenothiazine. According to the compound, a mesitylene group is introduced for the first time on the basis of a naphthoindolizine phenothiazine skeleton. The synthesis conditions are mild, and the yield is as high as 91%. In-vitro anti-cancer activity research shows that the compound has remarkable broad-spectrum anti-cancer activity and shows strong proliferation inhibition on human cervical cancer Hela cells (IC50 = 1.6 mu M), human lung cancer A549 cells (IC50 = 13.29 mu M) and human prostatic cancer PC-3 cells (IC50 = 19.1 mu M). Particularly, the activity on Hela cells is obviously superior to that of a clinical first-line drug cis-platinum. Preliminary toxicity evaluation shows that the toxicity of the compound to human normal umbilical vein endothelial cells (HUVEC) is far lower than that of cancer cells, and the selectivity is good.

The invention relates to a nonlinear optical chromophore having an organic indolizine electron-donating group, having the following general formula (I): D represents an indolizine electron-donating group. N represents an n-bridge between A and D, wherein the n-bridge comprises a carbon chain covalently bound to and separating A and D. A represents an organic electron accepting group having an electron affinity greater than the electron affinity of D. The organic indolizine electron-donating group D has one of the following formulae. Various embodiments of the present invention include a non-linear optochromic group having an indolizine donor group, which has an indolizine donor attached to a pi-bridge group. In various preferred embodiments of the invention, the indolizine donor groups may be substituted or unsubstituted, including hydrogen and alkyl substituents, aryl substituents, and combinations thereof. In certain embodiments of the invention, the substituent moiety in the indolizine donor group may be important for separation. The separation may reduce chromophore-chromophore interactions. Separation may reduce charge transfer between molecules. The separation may increase the maximum applied voltage, which may contribute to better polarization and higher r33.

The application provides a preparation method of a CO2 gas separation membrane, the separation membrane is composed of a base layer and a separation layer, the base layer is a self-polymerized microporous polymer, and the separation layer is a gel-assisted prepared film; the self-polymerized microporous polymer is prepared from tetrakisfluoroterephthalonitrile and tetrahydroxytetramethylspiro-linked indolizine through a condensation reaction; and the preparation method of the gel-assisted prepared film comprises the following steps: S1, preparing an oxidized sodium alginate solution containing aldehyde groups through an oxidation reaction of sodium alginate; S2, adding a polyamine compound and a rare earth metal salt into the oxidized sodium alginate solution containing aldehyde groups prepared in the step S1, then adding a polyethylene imine solution, and standing to form a gel; and adding trimesoyl chloride on the surface of the gel, drying the product after the reaction is completed, and obtaining the gel-assisted prepared film. The application further includes the CO2 gas separation membrane, and the CO2 gas separation membrane prepared by the application has strong selective permeation performance and high commercial value.

The application provides a synthesis method of a 2,3-dihydrobenzo-f quinoline compound, which comprises the following steps: taking pyridine quaternary ammonium salt and olefin as raw materials, C6F5I as a catalyst, 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as an additive, and reacting in air for 4-15 hours at a reaction temperature of 20-50 DEG C, removing the organic solvent by rotary evaporation, and separating the product by column chromatography. The raw materials are stable, cheap and easy to obtain; the raw material quaternary ammonium salt can be prepared from easily available pyridine and corresponding halide by a simple and efficient method, the raw material olefin is cheap and easy to obtain, the reaction is carried out in air, other oxidants are avoided, the additive DBU is cheap and easy to obtain, and the catalyst is used in a small amount. The method is simple, the target product is obtained by one-step synthesis, the reaction time is short, and the treatment is convenient. The reaction yield is considerable, and the method has industrial production potential.

The invention provides a metallocene compound and a preparation method thereof, a catalyst composition, a propylene homopolymerization method and an ethylene and alpha-olefin copolymerization method. The metallocene compound has a structure as shown in a formula I. Formula I. The metallocene compound containing indolizine and cyclopentadiene bridging is used as a main catalyst to be matched with a cocatalyst for use, is used for propylene homopolymerization, and has relatively high catalytic activity; the copolymerization activity of propylene and ethylene can also be improved, and relatively high toughness and good elongation at break are achieved; in addition, the catalyst can improve catalytic activity and monomer insertion rate in ethylene and alpha-olefin copolymerization.

The invention relates to the technical field of organic synthesis, in particular to a method for electrochemical synthesis of a 3-selenium cyano indolizine compound and application of the 3-selenium cyano indolizine compound. According to the method for electrochemical synthesis of the 3-selenium cyano indolizine compound, an indolizine compound, potassium selenide and an electrolyte are added into a solvent to form a reaction system, a graphite felt serves as an anode, a platinum sheet serves as a cathode, a constant-current reaction is conducted at the room temperature in the air atmosphere, the adopted current is 7 mA, and after the reaction is completed, the 3-selenium cyano indolizine compound is obtained. Carrying out post-treatment on the reactant to obtain a compound; the molar ratio of the indolizine compound to the potassium selenide cyanate is 1: (2-3), and the molar concentration of the electrolyte is 0.05 mol / L. The method has the advantages of wide substrate range, simple post-treatment and the like, and a new synthesis route and method are developed for the 3-selenium cyano indolizine compound. The obtained 3-selenium cyano indolizine compound shows remarkable anti-atherosclerosis activity and has the potential of being developed into an anti-atherosclerosis medicine.

The application discloses a transannular chiral indolizine compound (I) and a preparation method and application thereof. The structure of the compound of formula I is as follows: wherein R 1 , R 2 , R 3 , R 4 and Ar are defined in the description. The compound of the application shows significant circularly polarized luminescence performance, and a g lum value is as high as 0.01, which shows great application potential in chiral organic optoelectronic materials.

The present invention provides an amide-indolizine compound, a preparation method therefor, and a use thereof. The structure of the amide-indolizine compound is as shown in formula I. The amide-indolizine compound provided by the present invention can effectively degrade a CBP and / or p300 protein, and has an excellent anti-cancer effect.

The invention relates to the technical field of chemical synthesis, and particularly discloses an indolizine compound and a preparation method thereof. The structure of the indolizine compound is shown as a formula (I). The invention provides a preparation method of an indolizine compound based on a one-step addition reaction. The method has the outstanding advantages of mild reaction conditions, simple operation steps and the like, and effectively overcomes the common problems of tedious steps, harsh conditions and the like in the existing synthesis route. The establishment of an efficient synthesis route provides a reliable way for rapidly preparing indolizine derivatives with novel structures in a large scale, so that a solid material foundation is laid for deeply exploring brand new application of the compounds in the fields of drug discovery, material science and the like. The series of novel indolizine compounds with potential excellent biological activity provide a new opportunity for discovery of innovative drug lead compounds and development of novel functional materials, and have important research value and wide application prospects. Formula (I).

The invention discloses a preparation method of a medical intermediate (R)-7-ethyl camptothecin, and relates to the field of chemical drug synthesis. Comprising the following steps: taking (R)-4-ethyl-4-hydroxy-7, 8-dihydro-1H-pyrano [3, 4-f] indolizine-3, 6, 10 (4H)-trione (formula A) and 1-(2-aminophenyl) propan-1-one (formula B) as main raw materials, and reacting in an organic solvent under the action of a catalyst to obtain the target compound (R)-7-ethylcamptothecin. The invention provides a brand new preparation method of the pharmaceutical intermediate (R)-7-ethyl camptothecin, and the preparation method is simple and stable in process, high in yield and suitable for industrial production.

Provided herein are compositions and methods for detecting analytes. In particular, provided herein are tunable fluorescent indolizine and imidazo-triazines compounds and uses thereof (e.g., as probes or biosensors).

The invention provides an amide indolizine compound and a preparation method and application thereof, and the structure of the amide indolizine compound is as shown in formula I. The amide indolizine compound provided by the invention can effectively degrade CBP and / or p300 protein, and has an excellent anti-cancer effect.