51 results about "Cupric Ion" patented technology

The invention discloses a molecular probe for in-vivo copper ion detection and a preparation method and application thereof, the chemical structural formula of the molecular probe is as follows: # imgabs0 #, the molecular probe provided by the invention can specifically respond to copper ions in a tumor subacid environment so as to cause change of an absorption spectrum, and a photoacoustic signal is started so as to detect the copper ions in the tumor subacid environment. Normal tissues and tumor tissues can be accurately distinguished, and accurate detection of the copper ions in the living tumor is realized.

The invention discloses a biological patch material with dry-state adhesion and wet-state easy stripping characteristics and application thereof, and belongs to the field of biological medicine. The biological patch material is prepared according to the following steps: by taking water-soluble protein as a template and copper ions in water-soluble copper salt as a metal coordination center, carrying out self-assembly on the template and drug molecules with phenolic hydroxyl structures to form nanoflowers; mixing the acrylamide, the sodium alginate, the water-soluble calcium salt and the nano-flowers to obtain the water-soluble calcium-based water-soluble nano-flower fertilizer. The biological patch material is adhered to the skin through electrostatic interaction, covalent bonds, physical interpenetration and topological tissues. The patch has skin adhesion in a dry state, so that the patch is convenient to fix; after the patch is in contact with burnt skin, the patch absorbs water and swells, the adhesive force is obviously reduced, and painless, easy and non-invasive stripping is realized. In addition, the patch has immunoregulation performance, can prevent stimulation and anaphylaxis caused by long-term contact with the skin, and promotes burn repair.

The invention discloses a copper interconnection structure and a forming method thereof. The forming method comprises the following steps: providing a substrate; forming a dielectric layer on the substrate; forming a copper conductive structure in the dielectric layer; forming a covering layer on the dielectric layer; and performing first ultraviolet curing treatment on the covering layer and the dielectric layer. Heat assistance of the first ultraviolet curing treatment can help copper ions remaining on the surface of the dielectric layer to diffuse towards the interior of the dielectric layer so as to reduce the concentration of the copper ions on the surface of the dielectric layer. In addition, the first ultraviolet curing treatment can repair the damage of the surface of the dielectric layer in the planarization treatment process, so that the compactness of the top area of the dielectric layer is increased, and diffusion or drift of copper ions is hindered. In addition, the bonding strength between the dielectric layer and the covering layer can be enhanced through the first ultraviolet curing treatment, so that diffusion or drifting of copper ions is hindered. Therefore, after the covering layer is formed, the first ultraviolet curing treatment is favorable for weakening copper diffusion in the dielectric layer, so that the dielectric breakdown resistance of copper interconnection is enhanced.

The application discloses a preparation method of a fluorescein probe with specific selectivity and application thereof, and relates to the fluorescein probe field. The fluorescein probe with specific selectivity is prepared through the following steps: mixing a compound of formula (III) with 1,6-naphthylpyridine-2-methyl aldehyde in a solvent, adding triethylamine to obtain a compound of formula (II); mixing the compound of formula (II) with 1-pyrene carboxylic acid in a solvent, and adding dicyclohexyl carbodiimide and 4-dimethylaminopyridine to obtain the fluorescein probe with specific selectivity. The fluorescein probe with specific selectivity prepared by the application has excellent fluorescence performance, specific selectivity to copper ions, and extremely low detection limit, and has important application significance in copper ion detection.

The present application provides an extractant and a method for purifying copper-containing cyanide wastewater, belonging to the technical field of wastewater purification. The extractant uses an imidazole ring as the molecular backbone, and through a quaternization reaction, aliphatic chain functional groups are introduced to adjust the hydrophobic property of the extractant, ensuring that the extractant is insoluble in the inorganic aqueous phase. By derivatizing the amino group to form a thioester group, the terminal mercapto group hydrolyzes under alkaline conditions to form an S- activation site, which can effectively bond with cuprous ions (Ⅰ). At the same time, the S- activation site and the lone pair electrons on the adjacent N atom cooperate with each other to chelate cuprous ions (Ⅰ) to the greatest extent, ensuring that the cuprous ions exist in the form of chelates and will not be further converted into the free state. In addition, the lone pair electrons on the N atom and the carboxyl group can cooperate with each other to achieve targeted chelation of cupric ions (Ⅱ) in the solution. The present application realizes the efficient extraction of copper in the cyanide-containing wastewater, achieving the purpose of purifying the copper-containing cyanide wastewater.

The application provides an antiseptic and antibacterial coating composition, an antiseptic and antibacterial coating and a preparation method and application thereof. The antiseptic and antibacterial coating composition comprises an epoxy resin, a composite filler, a curing agent, a first surfactant and a first solvent; wherein the composite filler comprises a cuprous oxide core and an inorganic porous shell layer arranged on the surface of the cuprous oxide core, and a quaternary ammonium salt is also contained in the pore structure of the inorganic porous shell layer. By coating the inorganic porous shell layer on the surface of the cuprous oxide core, the release rate of cuprous ions from the cuprous oxide can be effectively reduced, and the side reaction between the cuprous oxide and the epoxy resin can be inhibited. By arranging the quaternary ammonium salt in the pore structure of the inorganic porous shell layer, the release rate of the quaternary ammonium salt can be effectively controlled, and the chemical stability of the quaternary ammonium salt can be improved, so that the double-channel slow release of cuprous ions and quaternary ammonium salt is realized, the synergistic effect of cuprous ions and quaternary ammonium salt in antibacterial and antiseptic aspects is improved, and the antibacterial and antiseptic performance of the prepared antiseptic and antibacterial coating is improved.

The invention belongs to the technical field of biological medicines, and particularly relates to a flavone-copper complex for promoting healing of diabetic foot ulcer, an external preparation of the flavone-copper complex, and a preparation method and application of the flavone-copper complex. According to the flavone-copper complex disclosed by the invention, a flavone compound and copper ions form the complex, so that the healing of the diabetic foot can be effectively promoted; meanwhile, after the flavonoid compound and the copper ions are compounded, slow release of the copper ions and the flavonoid components can be achieved, the medicine effect is improved, meanwhile, the potential toxicity of the copper ions is reduced, and the flavonoid compound can be directly used as a medicine for relieving ulcer of the diabetic foot.

The invention provides a copper ion imprinted cross-linked grafted chitosan adsorbent and a preparation method thereof. The preparation method comprises the following steps: adding an initiator into a mixed solution of a copper ion template agent and a chitosan solution to obtain a first reaction solution; carrying out grafting reaction on the first reaction solution to obtain a second reaction solution; adding a cross-linking agent into the second reaction liquid, carrying out cross-linking curing, and carrying out solid-liquid separation to obtain an intermediate; and eluting the copper ions in the intermediate to obtain the copper ion imprinted cross-linked grafted chitosan adsorbent. A solvent of the chitosan solution comprises water and unsaturated carboxylic acid. According to the preparation method disclosed by the invention, an ion imprinting technology is combined with crosslinking and grafting modification, so that the copper ion imprinting crosslinking grafted chitosan adsorbent is endowed with higher stability and selectivity, and the cyclic regeneration performance of the copper ion imprinting crosslinking grafted chitosan adsorbent is improved; the adsorption kinetics and the adsorption thermodynamics of the copper ion imprinted cross-linked grafted chitosan adsorbent are optimized.

The invention discloses a reactive copper ion near-infrared fluorescent probe as well as a preparation method and application thereof, and belongs to the technical field of copper ion near-infrared fluorescent probes. According to the technical scheme, the reactive copper ion near-infrared fluorescent probe is characterized in that the structural formula of the reactive copper ion near-infrared fluorescent probe is shown in the specification. The invention further specifically discloses a preparation method of the reactive copper ion near-infrared fluorescent probe and application of the reactive copper ion near-infrared fluorescent probe to selective detection of copper ions in an aqueous solution, a biological cell system and animal tissue. The near-infrared fluorescent probe disclosed by the invention has the advantages of fluorescence emission in a near-infrared region, good selectivity, low detection limit and the like.

The present invention discloses a temperature-responsive two-photon MOF-based fluorescent probe, its preparation method, and application, relating to the field of fluorescent probe technology. MOF-199 is used as a nanocarrier, simultaneously loaded with a photothermal agent, gold nanorods (Au NRs), and a temperature-responsive pyridinium salt molecule (B). MOF-199 can degrade in the acidic tumor microenvironment, and the released copper ions react with overexpressed H2O2 through a Fenton-like reaction to generate ·OH, inducing tumor cell apoptosis and achieving chemodynamic therapy. Au NRs, with high photothermal conversion efficiency, can achieve photothermal therapy under near-infrared light irradiation, and local hyperthermia can further accelerate ·OH generation, thereby accelerating the chemodynamic therapy process. B, with its two-photon response characteristics, can achieve real-time temperature monitoring under near-infrared light irradiation, and the coated phase change material film can effectively prevent B leakage, achieving temperature-controlled release.

The invention discloses a nano-drug for promoting cupric death of tumor cells and a preparation method of the nano-drug. The nano-drug comprises hyaluronic acid; a dopamine; copper ions; a diethyldithiocarbamic acid-copper conjugate; and a method for preparing the same. A peptide fragment with a targeting function; modifying a thiol ligand; the preparation method comprises the following steps: preparing a diethyl dithiocarbamic acid-copper conjugate, forming a nano-structure inner core, wrapping the conjugate, forming a copper ion protection layer, and purifying and carrying out targeted modification on a nano-drug. The preparation method comprises the following steps of: preparing the diethyl dithiocarbamic acid-copper conjugate, forming a nano-structure inner core, wrapping the conjugate, forming a copper ion protection layer, and carrying out targeted modification on the nano-drug. The copper ions are further fixed through the coordination effect of dopamine and the copper ions, wrapping of the diethyl dithiocarbamic acid-copper conjugate and the thiol-copper coordination effect of the modified thiol ligands, so that a double-coordination mechanism is formed, the loading capacity of the copper ions in the nano-drug is remarkably improved, and the stability of the nano-drug is improved. The copper death of tumor cells can be more effectively triggered, the copper ion loading capacity can be improved, and a material basis is provided for the efficient copper death effect.

The object of the present invention is to provide a near infrared absorbing composition which has both transmittance in the visible light region and absorptivity in the near infrared region, and which is excellent in heat resistance over time and light resistance. The near infrared absorbing composition of the present invention is a near infrared absorbing composition containing an organic pigment and a metal compound, characterized in that it contains at least one of a squarylium pigment (A) or a cyanine pigment (B) having an absorption maximum wavelength in the range of 680 to 740 nm, contains a cyanine pigment (C) having an absorption maximum wavelength of 760 nm or more, and further contains at least phosphonic acid and copper ions, or a copper phosphonate complex formed of phosphonic acid and copper ions.

The utility model discloses a sterilizing and disinfecting device for wastewater treatment in an operating room, which comprises a tank body, a bracket is fixedly arranged at the bottom of the tank body, universal wheels are arranged at the bottom of the bracket, the top of the tank body is communicated with an external thread pipe, the outer side of the external thread pipe is spirally connected with a rotary sealing cover, and the rotary sealing cover is connected with the tank body. A flow guide cone is fixedly mounted at the bottom of an inner cavity of the tank body, a lamp pole mounting seat is fixedly mounted in the top end of the flow guide cone, and an ultraviolet lamp pole is spirally mounted in the lamp pole mounting seat; through the arrangement of the metal net, stirring force is applied to water when the metal net rotates along with the structure, meanwhile, the contact area between the metal net and the water and flowing disturbance of water flow are increased, and metal copper and metal silver can generate a certain amount of copper ions and silver ions due to a small amount of hypochlorous acid generated by silver tap water disinfection chlorine in the water flow; and an ultraviolet lamp post is matched to play an auxiliary sterilization role on liquid in the tank body, so that the sterilization capability is improved.

The invention discloses a fluorescence-enhanced copper ion probe and preparation method and application. The method includes: 5,10-diformylphenyl-15,20-disulfonic acid phenyl metalloporphyrin (cis-MFTPPS), 2-hydrazine pyridine are dissolved in N, N-dimethylformamide with a molar ratio of 1:3, under nitrogen protection, heated to reflux, reacted 8-12h, after cooling, decompression distillation to remove the solvent, after reverse chromatographic column separation, in a 1000kDa dialysis bag, dialyzed for 48-55 hours to obtain a target copper ion fluorescent probe (MP). The probe preparation method is simple, the conditions are mild, and the post-processing is simple. The signal-enhanced fluorescent response to copper ions can be achieved in 100% aqueous solution, and the detection sensitivity is high, and the detection process is convenient.

The utility model discloses a stripping and hanging device and water electroplating equipment. And the stripping and hanging device is used for stripping and hanging a copper layer on the circularly moving workpiece from the coating process. The stripping and hanging device comprises a liquid storage mechanism and an electrolysis assembly. Wherein the liquid storage mechanism comprises a liquid storage tank, and the liquid storage tank is used for storing stripping and hanging liquid; the electrolysis assembly comprises a power supply, an anode terminal post and a cathode terminal post which are connected to the same electric loop, and the end parts of the anode terminal post and the cathode terminal post are used for being immersed in the stripping and hanging liquid. According to the stripping and hanging device and the water electroplating equipment disclosed by the utility model, at least the problem that the stripping and hanging effect of the stripping and hanging liquid on a copper layer on a conductive clamp is easily influenced because the concentration of copper ions in the stripping and hanging liquid for stripping and hanging the conductive clamp in the prior art can be solved.

The invention relates to the technical field of medical protective materials, and particularly discloses an antibacterial protective mask material, a preparation method thereof and a protective mask. The preparation method comprises the following steps: carrying out plasma modification on a polypropylene non-woven fabric to improve the surface activity and adhesive force; spraying a gelatin solution with a specific concentration, and drying to form a gelatin layer with a controllable coating amount; and dipping in a copper salt solution with a specific concentration, and fixing copper ions through coordination to form a gelatin-copper composite antibacterial layer. The method is simple and convenient in process, the prepared material has high-efficiency broad-spectrum antibacterial property, the inhibition rate on staphylococcus aureus can reach 90% or above, the copper ion release rate is low and can be controlled to be 1 ppm / day or below, and good air permeability is achieved. The antibacterial protective mask material prepared by the method and the protective mask containing the antibacterial protective mask material can effectively inhibit microorganism breeding and reduce the secondary infection risk, and are suitable for the medical and daily protection field.

The application provides a method for detecting the environment of a front opening unified pod. The method comprises the following steps: providing a monitoring wafer with a PN junction loop structure, a metal layer and a dielectric layer; placing the monitoring wafer into a pod to be detected for a predetermined time; and scanning the surface of the wafer by using a defect detection device to determine the environmental state inside the pod by detecting the defects caused by the migration of metal elements through the dielectric layer. The built-in electric field of the PN junction accelerates the migration of copper ions in a contaminated environment. By controlling the thickness of the dielectric layer and the storage time, and combining with dark field detection, it can quickly and sensitively detect whether there is residual water vapor or halogen elements in the pod. The method reduces human operation interference and can effectively monitor the micro-environmental risk in complex processes and improve yield control ability.

The present application relates to a kind of hyaluronic acid compositions and its application, belong to the technical field of skin care product.The composition of the present application contains blue copper peptide, can transport copper ion into cell, play the effect of repair, anti-aging, with the effect of significantly repairing skin, reducing skin fine lines and wrinkles.And sea fennel extract active ingredient can accelerate the metabolism of epidermis, effectively improve the self-healing ability of skin, quickly repair damaged site, promote the regeneration of cell tissue.In addition, the composition contains crosslinked sodium hyaluronate, on the one hand, it can be used as an elastic protective layer, can isolate the damage of skin by external harsh environment, on the other hand, the hyaluronic acid fragments produced by continuous degradation can induce subcutaneous angiogenesis after being absorbed by skin, increase the oxygen supply of skin, improve the skin condition.

An antioxidant copper particle with an oxalic acid compound-modified surface and its preparation method are disclosed. The particle's outer surface is coated with a cuprous oxalate complex film, and the particle's interior contains elemental copper. The preparation method is as follows: First, copper particles are mixed evenly with a solution, then oxalic acid is added, and the solution is brought to a boil. At this time, oxalic acid reacts with elemental copper or copper ions to form a cuprous oxalate complex film on the surface of the copper particles. Heating is then stopped, and centrifugation and washing are performed sequentially to obtain the antioxidant copper particles with the oxalic acid compound-modified surface. In application, the cuprous oxalate complex film can protect the copper particles and prevent them from being oxidized, thus giving the copper particles antioxidant properties. The cuprous oxalate complex film is stable and will not age, degrade, or volatilize over time under normal conditions, thus maintaining stable antioxidant capacity, which is beneficial for the long-term preservation of copper particles. Therefore, the protective film designed in this way has stable antioxidant capacity and is beneficial for the long-term preservation of copper particles.

The invention relates to the technical field of environmental protection and water treatment, and particularly discloses blue-green algae removal type glass pumice and a preparation method and application thereof. According to the blue-green algae removal type glass pumice, glass pumice serves as a carrier, copper ions are loaded through the processes of pretreatment, solution preparation, load impregnation and aftertreatment, and a copper-loaded glass pumice material is formed. In the preparation process, pore channels are dredged through ultrasonic cleaning pretreatment, the copper ion loading capacity is improved by combining a heating-cooling circulation method, and the final product controls the copper ions to be slowly and continuously released through the carrier and generates synergistic interaction with the algal inhibition effect of the glass pumice. The water body cyanobacteria can be safely inhibited and removed for a long time, and the preparation process is simple, low in cost and suitable for treatment of various eutrophic water body cyanobacteria.

This invention belongs to the field of carbon materials technology, and discloses a high-nuclear-core copper fullerene complex, its preparation method, and its applications. The chemical formula of this high-nuclear-core copper fullerene complex is 6(C7H). 10 N) + [Cu 30 Cl 36 (C 60 (C7H9N) 12 ] 6‑ ·3C7H9N. In this high-nuclearity copper fullerene complex, C 60 Provides a copper source with C=C double bonds, cuprous oxide as a monovalent copper ion, benzylamine, and Cl. ‑ To assist in coordination, high-nuclear copper fullerene complexes can absorb most of the near-infrared light, and the non-radiative transitions of the molecules are greater than the radiative transitions. They have high photothermal conversion efficiency and good electrical conductivity, as well as good photothermal stability, and can be recycled multiple times.

An automated system for predictive liquid quality management in high-performance computing (HPC) data center cooling infrastructure. The system periodically extracts coolant samples from a liquid loop and performs a series of analyses to detect potential contaminants and degradation factors, including copper ion concentration, dissolved metals, microbial activity, hardness, sulfur compounds and galvanic corrosion indicators. Analytical results are processed by an artificial intelligence module trained on historical coolant chemistry, server workload telemetry and quantifiable coolant loop and datacenter environmental factors to forecast deterioration events and generate alerts and reports for personnel. Frequency of sampling and testing can be adjusted. Based on predictive outcomes, the system generates corrective action recommendations such as filtration scheduling, sterilization, or maintenance alerts, without direct chemical dosing. By isolating liquid quality testing to periodic sampling and predictive analysis, the invention provides a novel approach to maintaining coolant integrity and operational reliability in HPC environments.

The application belongs to the technical field of antibacterial treatment, and particularly relates to carbon dots with photothermal and photodynamic dual-light therapy performance and a preparation method thereof. The application uses quaternary ammonium salt with antibacterial property as a carbon source, and the prepared carbon dots can retain the antibacterial property. Meanwhile, by doping copper ions, the absorption of the carbon dots in the near-infrared region is increased, the photothermal property is improved, and the bacterial damage is facilitated. In addition, the copper ions also have antibacterial property. On the basis of the bacterial killing mechanism of the quaternary ammonium salt, the PDT and PTT synergistic treatment is realized under single near-infrared wavelength excitation, which is helpful to overcome the drug resistance problem and has good application potential in the antibacterial field.

The present invention discloses a copper ion ratio fluorescent probe based on carbon dots, its preparation method and application. The ratio fluorescent probe is prepared as follows: polyethyleneimine and cysteine ​​are dissolved in deionized water or deionized water containing formamide, and the reaction is refluxed at 60-140°C for 0.5-24h. The ratio fluorescent probe is obtained by filtration, column chromatography separation, concentration and drying. The obtained ratio fluorescent probe is used to detect the copper ion ratio in different aqueous environments. 2+ The results showed that the different Cu 2+ The ratiometric fluorescent probe has a wide concentration range, with emission wavelengths of 489 and 680 nm serving as references. It exhibits high copper ion targeting specificity, rapid sensing, high sensitivity, and high accuracy, achieving a detection limit of as low as 3.13 nM for copper ions in complex physiological matrices. The ratiometric fluorescent probe exhibits high photostability, good water solubility, and high biosafety, making it suitable for the specific and precise detection of copper ions in biological samples and environmental water.

The invention provides an anti-corrosion and anti-bacterial coating composition, an anti-corrosion and anti-bacterial coating and a preparation method and application of the anti-corrosion and anti-bacterial coating. The anticorrosive and antibacterial coating composition comprises epoxy resin, composite filler, a curing agent, a first surfactant and a first solvent, wherein the composite filler comprises a cuprous oxide inner core and an inorganic porous shell layer arranged on the surface of the cuprous oxide inner core, and quaternary ammonium salt is contained in a pore structure of the inorganic porous shell layer. The surface of the cuprous oxide core is coated with the inorganic porous shell layer, the cuprous ion release rate of cuprous oxide can be effectively reduced, meanwhile, side reaction between cuprous oxide and epoxy resin is inhibited, quaternary ammonium salt is arranged in a pore channel structure of the inorganic porous shell layer, the release rate of the quaternary ammonium salt can be effectively regulated and controlled, and the chemical stability of the quaternary ammonium salt is improved; therefore, double-channel slow release of the cuprous ions and the quaternary ammonium salt is realized, the synergistic effect of the cuprous ions and the quaternary ammonium salt in the antibacterial and anti-corrosion aspects is improved, and the antibacterial and anti-corrosion performance of the prepared anti-corrosion and antibacterial coating is improved.

The utility model discloses a novel electrochemical treatment system for copper ions in sewage, and belongs to the field of energy conservation and environmental protection. The system comprises a controller, an equipotential instrument and a reaction tank, reaction main body equipment is fixed on a load platform in the reaction tank, two sides of the reaction tank are respectively provided with a water outlet and a water inlet, and the water inlet and the water outlet are respectively provided with an electromagnetic valve and a flow meter; wherein the reaction main body equipment comprises a cathode conducting ring and an anode conducting ring. The cathode, the anode and the reference electrode are respectively connected to an equipotential instrument, and then a controller is connected with an electromagnetic valve and a flow meter to realize parameter regulation and control. The electrostatic field effect is applied to the sewage, copper ions in the water are adsorbed on the surface of the cathode and are concentrated and enriched, and the effect of removing the ions in the water solution is achieved. Compared with a physical method, a chemical method and other methods, the electrochemical adsorption method has the advantages of high adsorption and capture efficiency, strong operability of the device, high stability and strong renewability, and has a great application prospect.

The invention provides a nano particle for radiotherapy-copper death combined treatment of breast cancer and a preparation method and application thereof, and is suitable for the field of nano particle preparation, and the nano particle comprises the following raw materials: 10 mg of precipitate A, 3-8 mg of CuCl2, 10 mg of DA.HCl, 2-6 mg of BSO, 100-250 [mu] l of a Tris-HCl buffer solution and 30-40 mg of BSA; the precipitate A comprises the following raw materials: hafnium tetroxide and polyvinylpyrrolidone in a mass ratio of 8: 5; the invention has the beneficial effects that the copper ions can be extrinsic conveyed to accumulate the copper ions in the cells and induce copper death, the radiation therapy and the BSO are combined to generate strong copper death, the radiation absorption and anti-tumor immunity of the tumor cells are enhanced, and the radiation resistance and tumor immunosuppression microenvironment can be effectively reversed.

The present application relates to the technical field of biomedical materials, and particularly relates to copper / oxygen defect barium titanate piezoelectric heterojunction nanoparticles and preparation and application thereof.The copper / oxygen defect barium titanate piezoelectric heterojunction nanoparticles of the present application take tetragonal phase barium titanate as a core, an oxygen defect amorphous layer as a shell, and a heterojunction is formed by depositing a non-valent copper nanocluster (Cu-Cu + ) on the surface of the shell layer; the copper / oxygen defect barium titanate piezoelectric heterojunction nanoparticles have an "electronic lever" effect, can be used for wound repair treatment by precisely regulating the "antibacterial-promoting repair" time sequence treatment under the action of ultrasound, and can rapidly and massively produce ROS and release copper ions under the action of ultrasound activation, so as to induce copper death of bacteria and achieve efficient antibacterial effect. Then, in the tissue repair stage, the ultrasound is turned off, and the intrinsic electric field of the heterojunction and the release of a small amount of copper ions are utilized to promote granulation tissue regeneration, collagen deposition, epithelial regeneration and angiogenesis, so as to synergistically accelerate tissue repair.

The application provides a kind of nanoparticle for radiotherapy-copper death combined treatment breast cancer and its preparation method and application, it is suitable for the preparation field of nanoparticle, wherein the nanoparticle includes the following raw materials: 10mg precipitate A, 3~8mg CuCl2, 10mg DA.HCl, 2~6mg BSO, 100~250ul Tris-HCl buffer solution and 30~40mg BSA;The precipitate A includes the following raw materials: the mass ratio of hafnium tetrachloride and polyvinylpyrrolidone is 8:5;With can be through exogenous delivery copper ion, make intracellular copper ion accumulation, induce copper death effect, combined radiotherapy and BSO, produce strong copper death, enhance the beneficial effect of tumor cell radiation absorption and antitumor immune effect, can effectively reverse radioresistance and tumor immunosuppression microenvironment.