22 results about "Cupric Ion" patented technology

The invention discloses a biological patch material with dry-state adhesion and wet-state easy stripping characteristics and application thereof, and belongs to the field of biological medicine. The biological patch material is prepared according to the following steps: by taking water-soluble protein as a template and copper ions in water-soluble copper salt as a metal coordination center, carrying out self-assembly on the template and drug molecules with phenolic hydroxyl structures to form nanoflowers; mixing the acrylamide, the sodium alginate, the water-soluble calcium salt and the nano-flowers to obtain the water-soluble calcium-based water-soluble nano-flower fertilizer. The biological patch material is adhered to the skin through electrostatic interaction, covalent bonds, physical interpenetration and topological tissues. The patch has skin adhesion in a dry state, so that the patch is convenient to fix; after the patch is in contact with burnt skin, the patch absorbs water and swells, the adhesive force is obviously reduced, and painless, easy and non-invasive stripping is realized. In addition, the patch has immunoregulation performance, can prevent stimulation and anaphylaxis caused by long-term contact with the skin, and promotes burn repair.

The application provides an antiseptic and antibacterial coating composition, an antiseptic and antibacterial coating and a preparation method and application thereof. The antiseptic and antibacterial coating composition comprises an epoxy resin, a composite filler, a curing agent, a first surfactant and a first solvent; wherein the composite filler comprises a cuprous oxide core and an inorganic porous shell layer arranged on the surface of the cuprous oxide core, and a quaternary ammonium salt is also contained in the pore structure of the inorganic porous shell layer. By coating the inorganic porous shell layer on the surface of the cuprous oxide core, the release rate of cuprous ions from the cuprous oxide can be effectively reduced, and the side reaction between the cuprous oxide and the epoxy resin can be inhibited. By arranging the quaternary ammonium salt in the pore structure of the inorganic porous shell layer, the release rate of the quaternary ammonium salt can be effectively controlled, and the chemical stability of the quaternary ammonium salt can be improved, so that the double-channel slow release of cuprous ions and quaternary ammonium salt is realized, the synergistic effect of cuprous ions and quaternary ammonium salt in antibacterial and antiseptic aspects is improved, and the antibacterial and antiseptic performance of the prepared antiseptic and antibacterial coating is improved.

The invention belongs to the technical field of biological medicines, and particularly relates to a flavone-copper complex for promoting healing of diabetic foot ulcer, an external preparation of the flavone-copper complex, and a preparation method and application of the flavone-copper complex. According to the flavone-copper complex disclosed by the invention, a flavone compound and copper ions form the complex, so that the healing of the diabetic foot can be effectively promoted; meanwhile, after the flavonoid compound and the copper ions are compounded, slow release of the copper ions and the flavonoid components can be achieved, the medicine effect is improved, meanwhile, the potential toxicity of the copper ions is reduced, and the flavonoid compound can be directly used as a medicine for relieving ulcer of the diabetic foot.

The invention relates to the technical field of medical protective materials, and particularly discloses an antibacterial protective mask material, a preparation method thereof and a protective mask. The preparation method comprises the following steps: carrying out plasma modification on a polypropylene non-woven fabric to improve the surface activity and adhesive force; spraying a gelatin solution with a specific concentration, and drying to form a gelatin layer with a controllable coating amount; and dipping in a copper salt solution with a specific concentration, and fixing copper ions through coordination to form a gelatin-copper composite antibacterial layer. The method is simple and convenient in process, the prepared material has high-efficiency broad-spectrum antibacterial property, the inhibition rate on staphylococcus aureus can reach 90% or above, the copper ion release rate is low and can be controlled to be 1 ppm / day or below, and good air permeability is achieved. The antibacterial protective mask material prepared by the method and the protective mask containing the antibacterial protective mask material can effectively inhibit microorganism breeding and reduce the secondary infection risk, and are suitable for the medical and daily protection field.

The present application relates to a kind of hyaluronic acid compositions and its application, belong to the technical field of skin care product.The composition of the present application contains blue copper peptide, can transport copper ion into cell, play the effect of repair, anti-aging, with the effect of significantly repairing skin, reducing skin fine lines and wrinkles.And sea fennel extract active ingredient can accelerate the metabolism of epidermis, effectively improve the self-healing ability of skin, quickly repair damaged site, promote the regeneration of cell tissue.In addition, the composition contains crosslinked sodium hyaluronate, on the one hand, it can be used as an elastic protective layer, can isolate the damage of skin by external harsh environment, on the other hand, the hyaluronic acid fragments produced by continuous degradation can induce subcutaneous angiogenesis after being absorbed by skin, increase the oxygen supply of skin, improve the skin condition.

An antioxidant copper particle with an oxalic acid compound-modified surface and its preparation method are disclosed. The particle's outer surface is coated with a cuprous oxalate complex film, and the particle's interior contains elemental copper. The preparation method is as follows: First, copper particles are mixed evenly with a solution, then oxalic acid is added, and the solution is brought to a boil. At this time, oxalic acid reacts with elemental copper or copper ions to form a cuprous oxalate complex film on the surface of the copper particles. Heating is then stopped, and centrifugation and washing are performed sequentially to obtain the antioxidant copper particles with the oxalic acid compound-modified surface. In application, the cuprous oxalate complex film can protect the copper particles and prevent them from being oxidized, thus giving the copper particles antioxidant properties. The cuprous oxalate complex film is stable and will not age, degrade, or volatilize over time under normal conditions, thus maintaining stable antioxidant capacity, which is beneficial for the long-term preservation of copper particles. Therefore, the protective film designed in this way has stable antioxidant capacity and is beneficial for the long-term preservation of copper particles.

The invention relates to the technical field of environmental protection and water treatment, and particularly discloses blue-green algae removal type glass pumice and a preparation method and application thereof. According to the blue-green algae removal type glass pumice, glass pumice serves as a carrier, copper ions are loaded through the processes of pretreatment, solution preparation, load impregnation and aftertreatment, and a copper-loaded glass pumice material is formed. In the preparation process, pore channels are dredged through ultrasonic cleaning pretreatment, the copper ion loading capacity is improved by combining a heating-cooling circulation method, and the final product controls the copper ions to be slowly and continuously released through the carrier and generates synergistic interaction with the algal inhibition effect of the glass pumice. The water body cyanobacteria can be safely inhibited and removed for a long time, and the preparation process is simple, low in cost and suitable for treatment of various eutrophic water body cyanobacteria.

This invention belongs to the field of carbon materials technology, and discloses a high-nuclear-core copper fullerene complex, its preparation method, and its applications. The chemical formula of this high-nuclear-core copper fullerene complex is 6(C7H). 10 N) + [Cu 30 Cl 36 (C 60 (C7H9N) 12 ] 6‑ ·3C7H9N. In this high-nuclearity copper fullerene complex, C 60 Provides a copper source with C=C double bonds, cuprous oxide as a monovalent copper ion, benzylamine, and Cl. ‑ To assist in coordination, high-nuclear copper fullerene complexes can absorb most of the near-infrared light, and the non-radiative transitions of the molecules are greater than the radiative transitions. They have high photothermal conversion efficiency and good electrical conductivity, as well as good photothermal stability, and can be recycled multiple times.

An automated system for predictive liquid quality management in high-performance computing (HPC) data center cooling infrastructure. The system periodically extracts coolant samples from a liquid loop and performs a series of analyses to detect potential contaminants and degradation factors, including copper ion concentration, dissolved metals, microbial activity, hardness, sulfur compounds and galvanic corrosion indicators. Analytical results are processed by an artificial intelligence module trained on historical coolant chemistry, server workload telemetry and quantifiable coolant loop and datacenter environmental factors to forecast deterioration events and generate alerts and reports for personnel. Frequency of sampling and testing can be adjusted. Based on predictive outcomes, the system generates corrective action recommendations such as filtration scheduling, sterilization, or maintenance alerts, without direct chemical dosing. By isolating liquid quality testing to periodic sampling and predictive analysis, the invention provides a novel approach to maintaining coolant integrity and operational reliability in HPC environments.

The invention provides a nano particle for radiotherapy-copper death combined treatment of breast cancer and a preparation method and application thereof, and is suitable for the field of nano particle preparation, and the nano particle comprises the following raw materials: 10 mg of precipitate A, 3-8 mg of CuCl2, 10 mg of DA.HCl, 2-6 mg of BSO, 100-250 [mu] l of a Tris-HCl buffer solution and 30-40 mg of BSA; the precipitate A comprises the following raw materials: hafnium tetroxide and polyvinylpyrrolidone in a mass ratio of 8: 5; the invention has the beneficial effects that the copper ions can be extrinsic conveyed to accumulate the copper ions in the cells and induce copper death, the radiation therapy and the BSO are combined to generate strong copper death, the radiation absorption and anti-tumor immunity of the tumor cells are enhanced, and the radiation resistance and tumor immunosuppression microenvironment can be effectively reversed.

The present application relates to the technical field of biomedical materials, and particularly relates to copper / oxygen defect barium titanate piezoelectric heterojunction nanoparticles and preparation and application thereof.The copper / oxygen defect barium titanate piezoelectric heterojunction nanoparticles of the present application take tetragonal phase barium titanate as a core, an oxygen defect amorphous layer as a shell, and a heterojunction is formed by depositing a non-valent copper nanocluster (Cu-Cu + ) on the surface of the shell layer; the copper / oxygen defect barium titanate piezoelectric heterojunction nanoparticles have an "electronic lever" effect, can be used for wound repair treatment by precisely regulating the "antibacterial-promoting repair" time sequence treatment under the action of ultrasound, and can rapidly and massively produce ROS and release copper ions under the action of ultrasound activation, so as to induce copper death of bacteria and achieve efficient antibacterial effect. Then, in the tissue repair stage, the ultrasound is turned off, and the intrinsic electric field of the heterojunction and the release of a small amount of copper ions are utilized to promote granulation tissue regeneration, collagen deposition, epithelial regeneration and angiogenesis, so as to synergistically accelerate tissue repair.

The application provides a kind of nanoparticle for radiotherapy-copper death combined treatment breast cancer and its preparation method and application, it is suitable for the preparation field of nanoparticle, wherein the nanoparticle includes the following raw materials: 10mg precipitate A, 3~8mg CuCl2, 10mg DA.HCl, 2~6mg BSO, 100~250ul Tris-HCl buffer solution and 30~40mg BSA;The precipitate A includes the following raw materials: the mass ratio of hafnium tetrachloride and polyvinylpyrrolidone is 8:5;With can be through exogenous delivery copper ion, make intracellular copper ion accumulation, induce copper death effect, combined radiotherapy and BSO, produce strong copper death, enhance the beneficial effect of tumor cell radiation absorption and antitumor immune effect, can effectively reverse radioresistance and tumor immunosuppression microenvironment.

The application belongs to the technical field of nanometer material synthesis, and particularly relates to a baicalein-copper nanometer microgel as well as a preparation method and application thereof. The application forms nanometer wires by coordination of copper ions and baicalein, and then forms the nanometer microgel by coating with hyaluronic acid (HA). The method is carried out at normal temperature, and has the advantages of simple process, high yield and no toxic solvent. The obtained microgel has high stability (resistant to gastric acid), targeted delivery (CD44 receptor mediation) and multiple biological activities (antioxidation and anti-inflammation). Animal experiments show that the microgel can significantly relieve ulcerative colitis, has a low dose of 5 mg / kg and no toxicity, and provides a new strategy for the treatment of inflammatory diseases.

The invention discloses application of hydrogel in preparation of an external preparation for treating wound scar infection risk, and belongs to the technical field of biomedical materials. The preparation method of the hydrogel comprises the following steps: preparing a copper ion solution with the mass fraction of 0.01%-0.05%, adding 0.1%-1% of sodium alginate into every 100 mL of the copper ion solution according to the mass fraction, adjusting the pH value to 4.5-5.5, and carrying out defoaming and sterile treatment to obtain the hydrogel capable of regulating and controlling the collagen proportion and reducing the risk of wound scar infection. According to the invention, a'regeneration type 'mode with a better healing guide structure and higher softness is adopted, so that the risks of hypertrophic scars, skin sclerosis and hardening after wound healing caused by fungal infection and the like are obviously reduced from the source. The application is suitable for high-quality repair of chronic wounds of human and pets.

The invention relates to an MOFs fluorescent molecular probe constructed based on post-synthesis modification (PSM) and application of the MOFs fluorescent molecular probe in copper ion detection. The structural formula of the probe is shown in the specification. A naphthalimide functionalized zirconium metal organic framework material is used as a fluorescent probe, a recognition group is added to the probe through a post-modification strategy, so that the probe containing a large number of Schiff base groups is exposed on the surface, and a specific coordination hydrolysis reaction with copper ions is utilized to trigger fluorescence quenching. Compared with long reaction time (needing min-level and h-level response time) of small molecules and high detection limit (19.7 [mu] M) of general macromolecules, ultrafast equilibrium fluorescence reaction (less than 5 s) and high sensitivity (the detection limit is 0.228 [mu] M) are generated. The sensitivity, selectivity, quick response and wide linear detection range are not influenced by other common metal ions. The method is used for qualitative detection of copper ions in actual water environments such as rainwater, drinking water, lake water and industrial wastewater.

The invention provides a method for rapidly detecting copper ions, a fluorescent sensor and application of the fluorescent sensor, belongs to the technical field of fluorescent nano sensing, and aims at solving the technical problems that an existing copper ion detection system is complex, operation is tedious and in-situ detection cannot be carried out. The rapid detection method for the copper ions comprises the following steps: mixing ascorbic acid, terephthalic acid and a buffer solution to prepare a standard solution; adding copper ions into the detection liquid, preparing a plurality of parts of detection liquid containing the copper ions with different concentrations, measuring the fluorescence spectrum of the detection liquid, and establishing a linear relation between the copper ion concentration and the fluorescence intensity; adding a to-be-detected solution into the standard solution, determining the fluorescence spectrum to obtain the fluorescence intensity, and obtaining the copper ion concentration in the to-be-detected solution through the linear relationship. According to the present invention, the operation is simple, the price is low, and the result is visual, such that the blood copper detection of the large-scale population can be dealt with, the detection cost and the detection difficulty can be reduced, and the prevention, the early discovery and the early treatment can be performed according to the diseases.

The invention provides copper ion hydrogel as well as a preparation method and application thereof, and the copper ion hydrogel is prepared from the following raw materials in percentage by mass: 0.02%-0.1% of soluble copper salt, 0.6%-8% of xanthan gum, 0.1%-1% of sodium hyaluronate, 0.5%-9% of butanediol, 0.1%-10% of glycerol, 0.02%-1% of betaine, 0.8%-9% of panthenol, 0.05%-1% of allantoin and the balance of water. The copper ion hydrogel can promote collagen regeneration, accelerate skin barrier structure reconstruction and improve chronic skin injury, and can be used for treating dermatitis skin diseases of pets.

The invention discloses a method for preparing copper-loaded biochar from moso bamboo and copper-containing wastewater, and belongs to the technical field of environmental functional materials and solid waste recycling. The method comprises the following steps: crushing moso bamboo wastes, mixing the crushed moso bamboo wastes with filtered and pH-regulated copper-containing wastewater, and carrying out constant-temperature oscillation to load copper ions on moso bamboo particles; performing solid-liquid separation and drying to obtain a precursor; and carrying out temperature programming pyrolysis in an inert atmosphere to prepare the copper-loaded biochar. The method takes wastes as raw materials, realizes treatment of wastes with wastes, and is simple in process and low in cost. The copper in the prepared biochar exists in high-activity forms such as zero-valent copper and cuprous, has rich pore structures and high specific surface area, can efficiently adsorb heavy metals and organic pollutants, can be used for advanced oxidative degradation of the organic pollutants, and has good environmental and economic benefits.

The invention relates to the technical field of etching solutions, in particular to a low-adsorption-capacity roughening micro-etching solution for cuprous ions as well as a preparation method and application of the low-adsorption-capacity roughening micro-etching solution. The coarsening micro-etching liquid with low cuprous ion adsorption capacity comprises the following raw materials: a composite oxidant containing a heterocyclic structure, cyclohexylamine, organic acid, a halide ion source, a copper ion source, a stabilizer and water. All the components in the raw materials have a synergistic effect, a layer of protective film is formed on the board surface of the base material, and adsorption of cuprous ions is reduced; meanwhile, cuprous ions are oxidized into copper ions under the action of a composite oxidizing agent containing a heterocyclic structure, so that the content of the copper ions in a hydrochloric acid solution in the subsequent pickling step is reduced, and the situation that the coarsening effect is affected by re-etching the coarsened honeycomb-shaped surface appearance due to the fact that the concentration of the copper ions is too high is prevented. In addition, a stabilizer is added into the roughening micro-etching liquid system with low cuprous ion adsorption capacity, the components are not easy to decompose, and the roughening micro-etching liquid system can be in a working state for a long time.

Disclosed in the present application is a use of a composition in treating atherosclerosis. Specifically, the present application relates to a use of a composition comprising microbubbles and copper ions in treating atherosclerosis.

The application provides a method and a kit for constructing a retinal pigment degeneration model, and relates to the technical field of biology. The method comprises administering a disulfiram-copper ion complex to a subject. The method alleviates at least one of the following defects in the prior art: a short model research window period, an unstable model, a complex construction method and high cost.