1538 results about "Hydrazide" patented technology

The invention relates to a plant growth regulator composition containing maleic hydrazide and the purposes thereof. The composition contains maleic hydrazide (A) and a combination of known plant growth regulators, such as paclobutrazol, uniconazole, cycocel, mepiquat chloride, triapenthenol, daminozide, ethephon, taterpex and thidiazuron, wherein the weight ratio of the (A) to the (B) is 1: 300 to 500:1 and preferable 1:100 to 300:1, the (A) and the (B) can be proportioned with known aids and an excipient to prepare any agriculturally acceptable preparation; and the agriculturally acceptable preparation can be diluted with water or soil into a needed concentration of 1-8000 mg/kg, preferable 50-5000 mg/kg and used for regulating the growth of cultured plants, such as hedge plants, lawns, landscape plants, fruit trees, vegetables, economic crops, food oil crops and forage grass through the treatments of irrigation, flood irrigation, fertilization with water, jetting, spraying, scattering, smearing, injecting, transfusing, dressing seeds, spreading fertilizer, dispersing, and the like. The composition has the advantages of wide range of applications, low cost, good effect and synergy.

The present invention relates to novel hydrazide-containing compounds of Formula I or Formula II, including pharmaceutically acceptable salts, esters, or prodrugs thereof which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

The present invention relates to an aqueous polyurethane coating composition comprising:

• 1) 1 to 99 wt. % of the reaction product of:
  • a) a polyol component, which is soluble or dispersible in water and is the reaction product of a polyisocyanate component containing 50 to 100 wt. % of an aliphatic diisocyanate, a polyol component containing one or more polyether polyols and having an OH number of 25 to 350 mg KOH/g solids and an isocyanate-reactive component containing at least one group capable of salt formation; and
  • b) polyisocyanate component, which is soluble or dispersible in water, has blocked isocyanate groups and is the reaction product of one or more polyisocyanates having an isocyanurate group content of 2 to 30 wt. %, a reversible, monofunctional blocking agent for isocyanate groups, a nonionic hydrophilic component and a stabilizing component which has 1 to 2 hydrazide groups and a molecular weight of 70 to 300; and
• 2) 1 to 99 wt. % of an aqueous polyurethane dispersion prepared from at least one polycarbonate polyol,

wherein the total wt. % of components 1) and 2) add up to 100%.

Disclosed herein are compositions comprising a compound represented by structural formula (I):

2 g of which is reconstitutable in 10 mL of a water in less than 10 minutes, and methods for preparing these compositions. Also disclosed are compositions comprising a compound represented by structural formula (I) and a pharmaceutically acceptable excipient, wherein the molar ratio of said compound to said excipient is from 1:20 to 1:1, and methods for preparing these compositions.

Methods for the manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency. Simplified purification processes can be employed to separate the conjugate product from the unconjugated protein and polysaccharide and other small molecule by-products.

Disclosed is a method of preparing a thiohydrazide product compound from a hydrazide starting compound. The hydrazide starting compound is represented by Structural Formula (I):

The thiohydrazide product compound is represented by Structural Formula (II):

In Structural Formulas (I)–(II), R₁ and R₂ are independently an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group, or R₁ and R₂ taken together with the carbon and nitrogen atoms to which they are bonded, form a non-aromatic heterocyclic ring optionally fused to an aromatic ring. When R₂ is an aryl group or a substituted aryl group, then R₅ is a hydrazine protecting group; and when R₂ is an aliphatic or substituted aliphatic group, then R₅ is —H or a hydrazine protecting group. R₁₀ is —H or a substituted or unsubstituted alkyl group. The method comprising the step of reacting the starting compound with a thionylating reagent.

The invention relates to a grease inhibitor for a caustic scrubbing tower of an ethylene plant and a method for using the same. The grease inhibitor consists of an alkylol amine compound, a hydrazide compound and an alkylamine compound. Moreover, the grease inhibitor not only overcomes the disadvantages of the prior inhibitor of high production cost, great toxicity and instable inhibition effect, but also effectively controls the output of grease inside the caustic scrubbing tower; meanwhile, the grease inhibitor reduces the discharge of waste lye and the consumption of fresh lye, and lightens the pressure on treating waste lye and environmental pollution caused by the grease.

Methods and medical devices for treating a proliferative disorder in a subject, e.g., restenosis in a blood vessel that has been implanted with a stent, employ a bis(thio-hydrazide amide) represented by Structural Formula I or a pharmaceutically acceptable salt or solvate thereof.

Y is a covalent bond or an optionally substituted straight chained hydrocarbyl group, or, Y, taken together with both >C=Z groups to which it is bonded, is an optionally substituted aromatic group.

R₁-R₄ are independently —H, an optionally substituted aliphatic group, an optionally substituted aryl group, or R₁ and R₃ taken together with the carbon and nitrogen atoms to which they are bonded, and/or R₂ and R₄ taken together with the carbon and nitrogen atoms to which they are bonded, form a non-aromatic heterocyclic ring optionally fused to an aromatic ring.

R₇-R₈ are independently —H, an optionally substituted aliphatic group, or an optionally substituted aryl group. Z is O or S.

Disclosed herein are methods of treating a proliferative disease, such as cancer, with bis(thio-hydrazide amides) or a tautomer, pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, in combination with hyperthermia treatment. Also disclosed are methods of treating a proliferative disease, such as cancer, with bis(thio-hydrazide amides) or a tautomer, pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, in combination with radiotherapy.

The present invention relates to a chemical reagent for detecting mercury ion in water and its preparation method. Said invention provides the structural formula of said reagent, and its preparation method includes the following steps: firstly, synthesizing rhodamine hydrazide, adding rhodamine dye in container, dissolving by using organic solvent, adding hydrazine hydrate, heating to make reflux reaction until the rhodamine dye colour is eliminated, filtering, washing the obtained solid by using water to obtain rhodamine hydrazide compound, adding organic solvent to dissolve said compound, adding aryl isothiocyanate, heating mixture and making reflux reaction, removing organic solvent, using column chromatography to make separation so as to obtain target product.

There are provided a rubber composition having a high modulus of elasticity and a good workability, and a pneumatic tire.A rubber composition comprising at least one of natural rubber and synthetic diene rubbers as a rubber ingredient, at least one maleimide compound, and at least one nitrogen-containing compound selected from the group consisting of polyaniline, hydrazide, and amine compound is used in a tread.

The invention provides compositions, pharmaceutical preparations and methods for inhibition of cystic fibrosis transmembrane conductance regulator protein (CFTR) that are useful for the study and treatment of CFTR-mediated diseases and conditions. The compositions and pharmaceutical preparations of the invention may comprise one or more hydrazide-containing compounds, and may additionally comprise one or more pharmaceutically acceptable carriers, excipients and/or adjuvants. The methods of the invention comprise, in certain embodiments, administering to a patient suffering from a CFTR-mediated disease or condition, an efficacious amount of a hydrazide-containing compound. In other embodiments the invention provides methods of inhibiting CFTR that comprise contacting cells in a subject with an effective amount of a hydrazide-containing compound. In addition, the invention features a non-human animal model of CFTR-mediated disease which model is produced by administration of a hydrazide-containing compound to a non-human animal in an amount sufficient to inhibit CFTR.

A method of preparing a bis(thio-hydrazide amide) disalt includes the steps of combining a neutral bis(thio-hydrazide amide), an organic solvent and a base to form a bis(thio-hydrazide amide) solution; and combining the solution and methyl tert-butyl ether, thereby precipitating a disalt of the bis(thio-hydrazide amide). In some embodiments, a method of preparing a bis(thio-hydrazide amide) disalt includes the steps of combining a neutral bis(thio-hydrazide amide) and an organic solvent selected from methanol, ethanol, acetone, and methyl ethyl ketone to make a mixture; adding at least two equivalents of a base selected from sodium hydroxide, potassium hydroxide, sodium methoxide, potassium methoxide, sodium ethoxide and potassium ethoxide to the mixture, thereby forming a solution; and combining the solution and methyl tert-butyl ether to precipitate the disalt of the bis(thio-hydrazide amide). The disclosed methods do not require lyophylization and the solvents used in the process can be more readily removed to low levels consistent with pharmaceutically acceptable preparation.

The invention discloses a quince preservative which is prepared by mixing cellulose, thiophanate methyl, carbendazim, p-hydroxybenzoic acid, vitamin C, maleic hydrazide and water. The invention has reasonable prescription, good preservation effect and low production cost. When in use, fruits are put in the preservative for 1 to 2 minutes.

The invention discloses a graphene oxide/hyaluronic acid nanometer drug carrier material. The graphene oxide/hyaluronic acid nanometer drug carrier material is characterized in that adipic acid hydrazide is covalently connected on the surface of monolayer graphene oxide, targeted molecular hyaluronic acid is further coupled by amino groups on the adipic acid hydrazide; the monolayer graphene oxide is 0.5-2nm thick; and the average size of the graphene oxide/hyaluronic acid nanometer drug carrier material is 50-300nm. According to the graphene oxide/hyaluronic acid nanometer drug carrier material provided by the invention, the hyaluronic acid is covalently modified on the surface of the graphene oxide and has a good targeting property; besides, the modified graphene oxide has good biocompatibility and benefits the biological application of the material; and moreover, the obtained functionalized nanometer material is expected to be used as a drug transmission carrier.

A rubber composition comprising 100 parts by weight of a rubber ingredient comprising natural rubber and/or a synthetic rubber, 0.1 to 50 parts by weight of at least one nitrogenous compound selected among benzimidazole derivatives having a specific structure and hydrazide derivatives having a specific structure, and 0.1 to 50 parts by weight of a protonic acid; and a pneumatic tire including a member formed from this rubber composition. The rubber composition enables excellent gripping performance while attaining intact productivity. The pneumatic tire produced from this rubber composition, in particular, the tire whose tread has been formed from the composition, has significantly improved gripping performance in high-speed driving, etc.

A composition of matter is disclosed wherein the composition comprises a hydrazide compound of the formula:

wherein:

R₁ is selected from the group consisting of alkyl, alkyl ether, and phenyl;

R₂, R₃, R₄, R₅, and R₆ are independently selected from the group consisting of hydrogen, alkyl, alkyl ether, and aryl; and n is an integer of from 0 to 10; and wherein:

when R₁ is phenyl, it is of the structure:

wherein R₇, R₈, and R₉ are independently selected from the group consisting of hydrogen, alkyl, alkyl ether, and aryl, or R₇ can be combined with R₈ to form a ring of 5 or 6 carbon atoms. The hydrazides are useful as stabilizers for lubricants, greases, and polymeric systems, particularly lubricating oils, as are maleated polymers that have been functionalized with them.

The invention generally relates to nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to a compound represented by structural formula I:

or a pharmaceutically acceptable salt thereof, wherein the values and alternative values for the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity.