270 results about "Hydrazide" patented technology

The invention discloses HA-PAS hydrogel for enhancing cartilage repair of early osteoarthritis and a preparation method of the HA-PAS hydrogel. According to the hydrogel, formylated hyaluronic acid, hydrazide modified low-methoxyl pectin and phenylboronic acid modified alginate form a ternary polysaccharide skeleton, a double-dynamic cross-linked network is formed through acylhydrazone bonds and boric acid ester bonds, and a triple network structure is formed by combining permanent cross-linking catalyzed by horse radish peroxidase. The hydrogel integrates functional components such as nano-selenium, a pulullan-strontium chelate and a mesenchymal stem cell source exosome, so that multiple effects of resisting oxidation, resisting inflammation, promoting cartilage differentiation and repairing subchondral bones are achieved. The compression modulus of the hydrogel is 0.8-1.5 MPa, and the hydrogel can be injected for in-situ gelling and MMP responsive degradation, shows an excellent cartilage repair effect in animal experiments, and provides a new solution for treatment of early osteoarthritis.

The invention discloses a preparation method of a photo-thermal conversion-phase change heat storage polyurethane flexible film, and relates to the technical field of polyurethane phase change materials. According to the invention, polyethylene glycol is used as a polymeric monomer and a phase change heat storage substrate, diisocyanate and dimethylolbutyric acid are used as reaction monomers, any one of 3, 3-dithio-bis-propionyl hydrazide or (R, R)-3, 3 '-diseleno-bis (2-aminopropionic acid) is used as a cross-linking agent, and transition metal carboxylate and a nano photo-thermal conversion agent are introduced to prepare the phase change heat storage material. And the polyurethane flexible film with photo-thermal conversion-phase change heat storage is prepared. A hydrazide group at the tail end of a cross-linking agent and an isocyanate group are subjected to nucleophilic addition reaction to generate a hydrazide-urea structure of which the main chain contains disulfide bonds and constructs multiple hydrogen bonds, and meanwhile, a metal carboxylate coordination bond is introduced, so that the film is endowed with an excellent mechanical response effect in a wide temperature range; the nano photo-thermal conversion agent is added into the system, so that the system has good photo-thermal conversion performance.

The invention generally relates to nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to a compound represented by structural formula I:or a pharmaceutically acceptable salt thereof, wherein the values and alternative values for the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment, modulation and / or prevention of physiological conditions associated with CRM1 activity.

The invention relates to the technical field of high polymer materials, and discloses a furyl polyurethane adhesive and a synthesis method thereof, polymer polyol is used as a soft segment, isocyanate and two specific furyl chain extenders are used as hard segments, polymerization is performed through a one-step method, and the method has the advantages of simple process, short flow, mild reaction conditions and the like. Wherein a furan ring and an amide group of the two specific furyl chain extenders endow the material with rigidity and excellent bonding performance, and form a high-density hydrogen bond network with a hydrazide group, so that the mechanical strength, the toughness and the bonding performance of the material are remarkably improved. By regulating and controlling the proportion of the components, the rigidity and flexibility of the material can be effectively balanced, so that the polyurethane adhesive with excellent comprehensive performance is prepared. The furyl polyurethane adhesive prepared by the invention has relatively high adhesion strength and mechanical strength, and can be applied to the fields of buildings, automobile manufacturing, medical treatment, packaging, aerospace, electronics and the like.

The invention relates to the technical field of pesticides, in particular to a hydrazide derivative containing a 3, 4-dihydroisoquinoline structure, a preparation method and application. The hydrazide derivative containing the 3, 4-dihydroisoquinoline structure is a compound as shown in a formula (I), or a stereoisomer, a tautomer, an isotope derivative and a pesticide acceptable salt thereof. The hydrazide derivative containing the 3, 4-dihydroisoquinoline structure has broad-spectrum inhibitory activity on phytopathogens such as plant pathogenic fungi, especially has excellent inhibitory activity on basidiomycota and ascomycomycota pathogenic fungi such as gaeumannomyces graminis, physalospora piricola, sclerotinia sclerotiorum, botrytis cinerea and rhizoctonia solani, and has broad-spectrum inhibitory activity. The bactericide is expected to be developed into a novel green bactericide which is efficient, safe, economical and environment-friendly.

A water-based coating composition comprising: water, (a) a binder comprising (a1) a core-shell latex copolymer with side-mounted carbonyl groups, and (b) a crosslinker comprising (b1) at least one polyhydrazide compound having at least two hydrazide groups of the formula -C(=O)-NH-N(R h )(R i ) includes, where R h and R i independent H or C1-C 12 -Alkyl groups, where the molar ratio of hydrazide groups to carbonyl groups is 5:1 to 1:5 in the composition.

The present application relates to the technical field of rubber, in particular to a kind of hydrazide compound, rubber composition and its preparation method and application.The present application provides a kind of hydrazide compound, is mono-hydrazide compound or double hydrazide compound, they have lower melting point, can be well dispersed in rubber matrix in the range of mixing temperature, further ensure its effect.And the hydrazide compound of this kind is added to rubber composition, can obtain the tire product of processing performance improvement, dynamic modulus promotion, anti-wet sliding and balanced rolling resistance.

The invention discloses a 3D printing polyurethane elastomer as well as a preparation method and application thereof, and relates to the technical field of high polymer materials. The polyurethane elastomer is composed of a prepolymer containing a dynamic hydrazide urea bond and a hindered urea bond and a monomer containing primary amine, the prepolymer takes polyether polyol and diisocyanate as basic raw materials, a dynamic hydrazide urea bond hard segment is introduced into the prepolymer through a hydrazide chain extender, a side chain is introduced through glycidyl methacrylate, and the primary amine-containing monomer is prepared. A dynamic hindered urea bond and a photocuring group are introduced through an acrylate end-capping reagent, and a reactive diluent and a photoinitiator are matched to optimize the forming performance. In the preparation process, a prepolymer and a primary amine-containing monomer are mixed and then subjected to 3D printing forming, in the low-temperature stage, reversible exchange of dynamic hydrazide urea bonds and hindered urea bonds is promoted to heal interlayer defects, and in the high-temperature stage, the hindered urea bonds are triggered to break and react with primary amine to form a stable cross-linked network. The 3D printing polyurethane elastomer has excellent rebound resilience, mechanical strength and hydrophobic effect.

The application belongs to the field of citrus cultivation, and particularly relates to a citrus coloring and sweetening composition and application. The main components of the citrus coloring and sweetening composition are maleic hydrazide and ethylene, and the mass ratio of the maleic hydrazide to the ethylene is 2:(1-4). The application is prepared by compounding maleic hydrazide and ethylene. The test results show that the application can promote early coloring of citrus, prevent reverse acidification of citrus after application of maleic hydrazide, increase average sugar content of citrus, has no negative effect on growth of citrus, has no pollution to the environment, and can be widely used in planting and production of different regions and different citrus varieties.

This invention belongs to the field of mineral flotation technology, and discloses a flotation collector for non-ferrous metal sulfide ores, its preparation method, and its application. The collector uses O,O-dialkyldithiophosphate as a starting material, and reacts sequentially with a halocarboxylic acid ester, hydrazine hydrate, potassium hydroxide, and carbon disulfide in anhydrous ethanol in a three-step reaction to obtain the target product, O,O-dialkyldithiophosphate hydrazide-N′-dithiocarbamate potassium. Its molecular structure simultaneously contains three active groups: a dithiophosphate group, an hydrazide group, and a dithiocarbamate group. This invention achieves efficient process connection and smooth transition by optimizing the material ratio, temperature, and time of each reaction step, and has advantages such as mild reaction conditions, simple operation, few side reactions, high yield, and stable product. The prepared collector exhibits excellent collecting performance and good selectivity for non-ferrous metal sulfide ores such as chalcopyrite, and is suitable for widespread application in sulfide ore flotation processes.

This invention relates to the field of polymer materials technology, specifically proposing a self-healing UV-curable electroplated aluminum color coating and its preparation method. By weight, it comprises: 30-50 parts polyurethane acrylic resin, 10-25 parts modified acrylic oligomer containing dynamic covalent bonds, 2-5 parts photoinitiator, 3-8 parts hydrophobically modified nanofiller, and 1-3 parts crosslinking agent. The dynamic covalent bonds are selected from at least one of hydrazide bonds, borate ester bonds, and Diels-Alder bonds. This invention achieves rapid self-healing and thermally triggered remodeling of the coating at room temperature through the introduction of a gradient energy synergistic network of dynamic covalent bonds and quadruple hydrogen bonds. Simultaneously, the microphase separation design of the hydrophobic core-shell filler and grafted modified silicon carbide nanowires enhances hydrolysis resistance.

The present invention discloses an itaconyl hydrazide-induced Janus structure polymer, which is a polymer prepared by gradient polymerization under ultraviolet light using itaconyl hydrazide and vinyl monomer as main raw materials. The present invention also discloses an itaconyl hydrazide-induced Janus structure polymer epidermal patch electrode, which is an epidermal patch electrode obtained by connecting the polymer to the electrode and integrating it into a signal processing module. The itaconyl hydrazide-induced Janus structure of the present invention and the hydrogen bond network formed thereby give the polymer excellent stretchability, flexibility, and homogeneous conformal properties, which can ensure the high signal-to-noise ratio, high stability and reliability of the polymer epidermal patch electrode for electrocardiogram signal monitoring. The polymer epidermal patch electrode of the present invention can be used for electrocardiogram signal monitoring in different environments, different motion states, and when worn for a long time, and is particularly applicable to the application of epidermal patch electrodes in wearable health monitoring.

The invention discloses a cushion rubber composition with high fatigue performance as well as a preparation method and application thereof, and belongs to the technical field of rubber tires. According to the invention, N326 is used as main reinforcing carbon black in the cushion rubber and is matched with the hydrazide compound, and the fatigue performance of the cushion rubber formula is improved by using high-precision / purity N326 carbon black and adjusting formula components; due to the application of high-precision / purity N326, the heat generation of the formula is improved, so that the fatigue performance of the formula is reduced; a complex generated by the hydrazide compound and zinc oxide can stabilize cross-linking bonds and cross-linking density, and degradation and fatigue performance reduction caused by heat accumulation in the repeated movement process of the rubber material are avoided.

To provide an adhesive film which exhibits low temperature quick curability and good adhesive strength and connection reliability, can be narrowly and stably slit, and has good temporary stickiness.SOLUTION: An adhesive film has a base material film subjected to release treatment, and an insulation resin layer which is provided thereon and exhibits radical polymerizability and anion polymerizability, and has a film width of 1.0 mm or less, further 0.8 mm or less, and has a length of 5 m or more. The insulation resin layer contains: a radical polymerization initiator which contains a film-formation component containing two kinds of film components having different molecular weights, a radical polymerizable component containing a first acrylic compound, an anion polymerizable component containing an epoxy-based compound, and an organic peroxide having a one-min half-life temperature of 125°C or lower; and an anion polymerization curing agent which is solid at normal temperature and contains an organic acid hydrazide compound.SELECTED DRAWING: Figure 1A

The invention provides a preparation method of a bio-based reversible cross-linked polyurethane hot melt adhesive. The method comprises the following steps: firstly, carrying out polymerization reaction on bio-based polyol PO3G (poly trimethylene ether glycol) and isophorone diisocyanate which are used as raw materials to prepare an isocyanate-terminated bio-based prepolymer; then, diethyl toluenediamine and isophthaloyl hydrazine are adopted as a mixed chain extender for a chain extension reaction, and after drying treatment, the bio-based polyurethane hot melt adhesive is obtained. The bio-based hot-melt adhesive prepared by the invention is suitable for hot-melt sealants in the field of electronic devices. The adhesive shows good bonding performance to a stainless steel base material, the tensile shear strength reaches 0.45-0.5 MPa, the adhesive has excellent reversible disassembly characteristic, and convenient separation of a bonding interface can be achieved by heating at 100 DEG C for 10 minutes.

The invention discloses a COF-based heterogeneous iodobenzene catalyst and its preparation method and application, belonging to the field of catalyst preparation technology. The COF-based heterogeneous iodobenzene catalyst is obtained by polymerizing a hydrazide monomer containing an iodophenyl group unit and 1,3,5-tris(4-formylphenyl)triazine; the structural formula of the hydrazide monomer containing an iodophenyl group unit is: The COF-based heterogeneous iodobenzene catalyst can be used as a catalyst for the chlorination reaction of anisole, catalyzing the chlorination reaction of anisole, achieving heterogeneous catalysis, and using a small amount, easy to recover, improving the utilization rate of the catalyst, and reducing the cost of anisole chlorination.

A film-forming thermoset coating composition includes: (a) an aqueous medium; and Option 1 and / or Option 2 as follows: Option 1: (b1) polyurethane-acrylate core-shell particles including a polymeric acrylic core at least partially encapsulated by a polymeric shell including urethane linkages, where the polymeric shell includes an acid functional group and two or more hydrazide functional groups, where the polymeric shell is covalently bonded to at least a portion of the polymeric core; and (c1) (i) formaldehyde; (ii) polyformaldehyde; and / or (iii) a compound that generates formaldehyde; Option 2: (b2) polyurethane-acrylate core-shell particles including a polymeric acrylic core at least partially encapsulated by a polymeric shell including urethane linkages, where the polymeric shell includes an acid functional group and two or more N-methylolated hydrazide functional groups, where the polymeric shell is covalently bonded to at least a portion of the polymeric core.

NEW FORMULATIONS OF MALEIC HYDRAZIDE This application concerns new plant protection formulations of maleic hydrazide (MH) in the form of ethanolamine salts, and their use in diluted form for application on plant products. Figure for abstract: None

A combination for use in treating cancer is provided. The combination comprises a therapeutically effective amount of an inhibitor of nuclear import protein Karyopherin Beta 1 (Kpnβ1) such as the substituted pyrrolo[2,3-b]quinoxalines of Formula I and a therapeutically effective amount of an inhibitor of nuclear export protein Chromosome Maintenance 1 (Crm1) such as the hydrazide- containing compounds of Formula II. The combination therapy provides an enhanced anti-cancer therapeutic effect compared to the effect of each of the nuclear transport inhibitors administered alone.

A multistep continuous flow synthesis method for the manufacture of isonicotinyl-hydrazide (Isoniazid) comprising reacting 4-cyano pyridine with NaOH at a specified molar ratio and temperature range to produce the intermediate isonicotinamide, which intermediate is reacted with hydrazine hydrate, without isolation thereof, at a specified molar ratio and temperature range to produce isonicotinyl-hydrazide (Isoniazid) in a yield greater than about 90%.

The invention provides a polymer fluorescent nano-film, a template-free self-assembly preparation method thereof and application of a nerve poison sensing detection agent, and the polymer fluorescent nano-film is prepared on a gas-liquid interface through dynamic acylhydrazone bond condensation reaction by taking a column [5] arene hydrazide derivative and tetraformyl tetraphenylethylene as film building monomers. The polymer fluorescent nano-film is prepared through template-free self-assembly, the preparation process is simple, the conditions are mild, and the accurate regulation and control of the film thickness can be realized by changing the concentration of the precursor solution or the volume of the solution per unit area. The prepared film has a flat, smooth and defect-free surface, has excellent mechanical properties, shows good toughness and puncture resistance, shows excellent sensing performance on a nerve toxic agent simulant diethyl chlorophosphate, has excellent detection capability on a real nerve toxic agent sarin under the assistance of a solvent, and can be widely applied to the field of neurology and neurology, such as neurology, neurology, neurology, neurology, neurology, neurology, neurology, neurology, neurology, neurology, neurology and neurology. The method is expected to play an important role in the fields of public place safety monitoring and the like, and has a wide application prospect.

The present application relates to the technical field of pesticides, and discloses a chromene aryl hydrazide derivative, a preparation method and application thereof, a structural general formula of the chromene aryl hyydrazide derivative is as formula (I); the preparation method is as follows: taking p-hydroxybenzaldehyde as raw material, and obtaining the chromene aryl hydrazide compound through substitution reaction, cyclization reaction, oxidation reaction, acylation reaction and hydrazinolysis reaction. The chromene aryl hydrazide compound is used for preparing an agricultural bacteriostatic agent. The present application combines aryl hydrazine and chromene skeleton by using the pharmacophore splicing principle in medicinal chemistry, and designs and synthesizes a series of chromene aryl hydrazide compounds. The bacteriostatic activity test result shows that the compounds have excellent bacteriostatic activity, and can be used as active ingredients for preparing a plant pathogenic fungus fungicide.

The invention relates to the technical field of structural adhesives, in particular to an epoxy composition capable of being used for bonding a camera module support and a preparation method of the epoxy composition, and the epoxy composition comprises the following components in parts by weight: 7-10 parts of epoxy resin; 20-25 parts of flexible epoxy resin; 5-10 parts of a core-shell epoxy resin toughening agent; 20-25 parts of a compound filler; 30 to 31 parts of organic hydrazide; and 8-9 parts of a modified amine adduct. The flexible epoxy resin has at least one structural characteristic of a long-chain polyether structure and an indene structure. The compound filler comprises calcium carbonate and silicon dioxide. The epoxy composition capable of being used for bonding the camera module support has the advantages of low precipitation, low curing shrinkage, high bonding strength, low modulus and excellent falling resistance, the reliability of the camera module support structure can be remarkably improved, and the epoxy composition is suitable for application environments of various miniature high-performance camera modules.

The present invention provides an inkjet ink in which the colorant is stably and highly dispersed, has excellent injection stability (droplet formation and droplet recovery), and can improve the texture and friction fastness of printed materials. [Solution] An inkjet ink comprising a urethane resin having (A) a structural unit derived from polyisocyanate, (B) a structural unit derived from polyol, and (C) a structural unit derived from polyamine, and an organic solvent, wherein the (B) polyol comprises (B1) a polyether polyol and (B2) a diol compound having a carboxyl group and / or a carboxylate group, and the (C) polyamine comprises (C1) a first polyamine having two groups selected from an amino group, an imino group, and a hydrazide group, and (C2) a second polyamine having three or four groups selected from an amino group, an imino group, and a hydrazide group, and the mass ratio of the organic solvent to the urethane resin (mass of organic solvent / mass of urethane resin) is 1.0 or more.

There is provided a resin composition including a resin having an alkyl group on a side chain of a molecule thereof, an inorganic filler and an antioxidant, wherein the antioxidant is either of a hydrazide-based antioxidant or a combination of a hindered phenol-based antioxidant and an organic metal chelate-based antioxidant.

The present invention provides a gel polymer electrolyte precursor solution, a gel polymer electrolyte, a preparation method thereof, and a secondary battery. The gel polymer electrolyte precursor solution includes a deep eutectic solution, which includes a hydrogen bond donor monomer, a hydrogen bond acceptor monomer, and a metal salt; wherein the hydrogen bond donor monomer includes any one of methacryloyl hydrazide or acryloyl hydrazide or a combination of at least two, and the hydrogen bond acceptor monomer is selected from unsaturated sulfobetaine zwitterionic monomers. The gel polymer electrolyte prepared by the present invention has high ionic conductivity, is non-flammable, and has good thermal stability, thereby significantly improving the operational stability and safety of secondary batteries and having broad application prospects.

The application provides a copper adsorption material and a preparation method and application thereof, and the copper adsorption material is prepared by using salicylic hydrazide monomers and methacrylic acid as raw materials through an emulsion polymerization method. The salicylic hydrazide monomers used in the application are salicylic hydrazide derivatives with introduced propylene bonds, and the multi-dentate coordination structure of the salicylic hydrazide derivatives can specifically chelate copper ions; the hydrophilic monomer used is methacrylic acid, and the carboxyl group of the methacrylic acid can bring good hydrophilic performance to the material and improve adsorption kinetics. The copper adsorption material of the application is applied to a mixed solution containing copper ions, nickel ions and cobalt ions to selectively separate copper ions.

The invention relates to a thermally expandable composition comprising: a) At least one thermoplastic polymer TP and / or at least one solid rubber R and b) At least one polymeric blowing agent BA selected from the group consisting of sulfonyl hydrazide-functionalized polymers, sulfonyl semicarbazide-functionalized polymers, carbamate-functionalized polymers, and ureido carbamate-functionalized polymers, wherein the polymeric blowing agent BA has a number average molecular weight (Mn) determined by gel permeation-chromatography (GPC) using polystyrene 0 as standard of at least 500 g / mol, preferably at least 750 g / mol.

The present application belongs to the technical field of herbicide safener, and particularly relates to the use of chlorindole hydrazide as a herbicide safener, chlorindole hydrazide as a safener of nicosulfuron, carfentrazone-ethyl, benzenesulfonamide and quizalofop-p-ethyl, which can relieve or eliminate the crop phytotoxicity caused by the above herbicides, and is applied after or before the crop phytotoxicity is caused. The application amount of chlorindole hydrazide (converted into the original drug) is 1-2 g / mu, the mass concentration of chlorindole hydrazide is 0.00667-0.01333% when applied, and a very good control effect can be achieved.

The invention relates to a novel chemical cross-linking agent with mass spectrum fragmentable trehalose disaccharide as a skeleton structure and a preparation method thereof. The cross-linking agent disclosed by the invention has the following characteristics: 1) trehalose disaccharide is used as a skeleton structure, so that the cross-linking agent has excellent biocompatibility; 2) the trehalose skeleton has a pair of symmetrical mass spectrum fragmentable glucosidic bonds, so that a cross-linked peptide fragment can be simplified into a conventional peptide fragment modified by a cross-linking agent fragment; 3) the enrichment of the cross-linked peptide fragment can be realized by the trehalose skeleton under the condition of not adding an enrichment handle; and 4) active groups of the cross-linking agent comprise but not limited to a plurality of reactive groups such as succinamide ester, diaziridine, phenylsulfonyl fluoride, hydrazide group, amino group, hydroxylamine group and the like, and chemical cross-linking of a plurality of amino acids except lysine is realized. The trehalose cross-linking agent disclosed by the invention is applied to the field of proteomics, and provides technical support for realizing large-scale analysis of a protein complex in a complex sample, spatial structure analysis of protein and a protein-protein interaction network.