82 results about "Aminophenylboronic acid" patented technology

The invention belongs to the technical field of preparation and application of nano materials, and relates to a preparation method and application of amino-functionalized cerium oxide nano enzyme, and the preparation method comprises the following steps: adding 3-aminophenylboronic acid into a cerous nitrate hexahydrate aqueous solution to obtain a mixed solution; dropwise adding a sodium hydroxide aqueous solution into the mixed solution, carrying out hydrothermal reaction, cooling after the reaction is finished, centrifuging, washing and drying to obtain milk white powder, namely the amino-functionalized cerium oxide nano-enzyme. The boron element is introduced in the preparation of the cerium oxide nano-enzyme, and the amino-functionalized cerium oxide nano-enzyme is prepared by adopting a simple one-step hydrothermal synthesis method, so that the nano-enzyme has good phosphatase-like activity, has high selectivity and sensitivity to LPS, and is short in detection time, high in sensitivity, low in detection limit, simple in preparation process and high in preparation efficiency; the product is good in quality, high in stability, environment-friendly and extremely wide in market prospect.

The invention relates to the field of pouring sealants, and discloses a modified epoxy resin pouring sealant and a preparation method thereof, the pouring sealant comprises epoxy resin, a modified inorganic filler, a modified additive and an auxiliary agent; the modified inorganic filler is prepared by grafting a quaternized s-triazine derivative and an inorganic filler; the quaternized s-triazine derivative is prepared through the steps that 3, 5-diaminophenylboronic acid, cyanuric chloride, 3-chloropropyltrimethoxysilane and 1, 4-butanediamine are sequentially subjected to substitution to prepare a s-triazine derivative, then the s-triazine derivative reacts with N, N-dimethyl-1, 3-diaminopropane, and bromoethane is used for quaternization treatment. The modified additive is prepared from a modified bismaleimide monomer prepared from maleic anhydride and 5 (6)-amino-1-(4-aminophenyl)-1, 3, 3-trimethylindane and 1-methyl-4-isopropyl cyclohexene through a self-stabilization precipitation polymerization method, the prepared pouring sealant is high in tensile strength, good in impact resistance and good in mechanical property, and the prepared pouring sealant has the advantages of being good in mechanical property, good in mechanical property and good in mechanical property. Meanwhile, good heat resistance, flame retardance, dielectricity and antibacterial activity are achieved.

The invention discloses fluorine-containing bio-based epoxy resin as well as a preparation method and application thereof, and relates to the technical field of high polymer materials. The preparation method of the fluorine-containing bio-based epoxy resin comprises the following steps: enabling octafluoropentyloxy glycidyl ether as a fluorine unit to react with dihydric alcohol to obtain fluorine-terminated side chain butanediol, enabling the fluorine-terminated side chain butanediol to react with isocyanate to obtain a polyurethane prepolymer, and performing boric acid end capping on the polyurethane prepolymer by using 3-aminophenylboronic acid to obtain the fluorine-containing bio-based epoxy resin. The fluorine-containing bio-based epoxy resin (FBPU-ER) is prepared by the following steps: adding fluorine-containing polyurethane resin and phenylboronic acid into epoxidized soybean oil to obtain phenylboronic acid modified fluorine-containing polyurethane resin (FBPU), carrying out boric acid treatment on the epoxidized soybean oil by using 3-aminophenylboronic acid to obtain phenylboronic acid modified epoxy resin (BER), and finally, mixing the phenylboronic acid modified fluorine-containing polyurethane resin and the phenylboronic acid modified epoxy resin to obtain the fluorine-containing bio-based epoxy resin (FBPU-ER). The fluorine-containing bio-based epoxy resin prepared through fluorine-containing modification and toughening design has good mechanical properties, stability and self-repairing performance.

An N-heterocycle-containing boric acid compound and a preparation method and application thereof are provided. The preparation method adopts 3-bromo-1-p-tosyl-1H-pyrrolo[2, 3-b]pyrimidine as a raw material to generate (3-((5-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)boric acid by three steps of reaction. The (3-((5-chloro-4 (1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)boric acid has good inhibition effect on the proliferation activity of brain glioma, which is proven by cell experiments.

The invention discloses ROS (reactive oxygen species) responsive hydrogel loaded with hypoxia-induced exosome as well as a preparation method and application of the ROS responsive hydrogel. The ROS responsive hydrogel comprises an ROS responsive hydrogel matrix and a hypoxia-induced exosome dispersed in the ROS responsive hydrogel matrix, and the ROS responsive hydrogel matrix is prepared by uniformly mixing hyaluronic acid grafted with 3-aminophenylboronic acid and epsilon-polylysine grafted with caffeic acid. Under a high ROS environment, boric acid ester bonds in the hydrogel can be destroyed to release exosomes and caffeic acid, and the exosomes induced by hypoxia contain more factors for promoting tissue repair and regeneration and also have the competitive advantage of high uptake rate. The ROS responsive hydrogel loaded with the hypoxia-induced exosome can realize on-demand release of the exosome, delivers the exosome with endogenous competitive advantages to an ischemic infarction region and removes excessive active oxygen to play a role in efficiently repairing myocardial infarction.

This invention discloses a hyaluronic acid-phenylboronic acid-methotrexate antitumor conjugate and its preparation method in the field of drug preparation technology. First, hyaluronic acid is activated with carboxylic acid, then subjected to an amidation reaction with 3-aminophenylboronic acid to obtain a hyaluronic acid-phenylboronic acid conjugate. Next, methotrexate is activated and added to the hyaluronic acid-phenylboronic acid mixture, followed by stirring to obtain the hyaluronic acid-phenylboronic acid-methotrexate antitumor conjugate. The preparation method of this invention is simple. While the three drugs exert their respective effects, the introduction of phenylboronic acid enhances the targeted antitumor effect of the drug. The combined use of hyaluronic acid and phenylboronic acid further reduces the toxic side effects of methotrexate and improves the biocompatibility, bioavailability, and degradability of the resulting drug, making it suitable for application in the preparation of antitumor drugs.

The invention belongs to the technical field of biomedical materials and biomedical engineering, and discloses peach gum-based self-repairing moisturizing hydrogel, a preparation method and application of the peach gum-based self-repairing moisturizing hydrogel in hemostasis and moisturizing materials. The preparation method comprises the following steps: carrying out an amide reaction on 3-aminophenylboronic acid hydrochloride (3APBA), and grafting the 3-aminophenylboronic acid hydrochloride (3APBA) on purified peach gum to obtain boronic acid peach gum (PR-3APBA); and adding an efficient humectant sodium pyrrolidone carboxylate, and freeze-drying to obtain the self-repairing hemostatic moisturizing gel. The adhesive has excellent hemostasis, moisturizing and self-repairing functions, is applied to body surface skin wound repair, and particularly has better wound repair performance and tissue adhesion performance when being used as an adhesion hemostasis material.

The invention discloses a protamine derivative and application thereof, the protamine derivative is obtained by modifying phenylboronic acid on a protamine side chain amino group, and the phenylboronic acid is selected from 4-carboxyphenylboronic acid, 2-aminophenylboronic acid, 3-carboxyl-4-fluorophenylboronic acid or 4-formyl chlorophenylboronic acid; the protamine derivative can be combined with a nucleic acid drug through a boric acid group and is used as a delivery carrier for preparing a nucleic acid drug delivery system. The invention provides a preparation scheme of phenylboronic acid modified protamine, the phenylboronic acid modified protamine is applied to nucleic acid drug delivery, after phenylboronic acid is modified, a boric acid ester bond is formed between a carrier and nucleic acid, and the nucleic acid drug can be responsively released in a high-concentration ATP environment. The functional modified protamine obviously improves the stability of a nucleic acid delivery system, enables the release of a nucleic acid drug to be controllable, and enhances the curative effect of gene therapy.

The invention discloses a trithiophene type fluorescent probe for detecting total polar substances of edible oil as well as a preparation method and application of the trithiophene type fluorescent probe. The preparation method comprises the following steps: directly carrying out a coupling reaction on 4-bis (4-methoxyphenyl) amino] phenyl]-[2, 2 ': 5', 2 ''-trithiophene-5-formaldehyde and 4-bis (4-methoxyphenyl) aminophenylboronic acid to prepare 5''-[4-[bis (4-methoxyphenyl) amino] phenyl]-[2, 2 ': 5', 2 ''-trithiophene-5-formaldehyde, and reacting the compound with 4-methylquinoline to synthesize the probe (E)-4-methoxy-N-(4-methoxyphenyl)-N-[4-(5''-(2-(quinoline-4-yl) vinyl)-[2, 2 ': 5', 2 ''-trithiophene-5-formaldehyde. The compound can selectively detect the polarity of edible oil, yellow fluorescence is quenched after the polarity of the edible oil is increased, and the compound can be used as a fluorescent probe for detecting the polarity of the edible oil.

This invention provides the application of glucose-responsive nanohydrogels in the preparation of drugs for treating skin injuries. The method includes the following steps: mixing hyaluronic acid with a phenylboronic acid compound, adding 3-aminophenylboronic acid, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride and N-hydroxysuccinimide, and performing a grafting reaction to obtain boric acid-modified hyaluronic acid; adding myricetin-3-O-galactoside, phospholipids, and cholesterol to an organic solvent, followed by thin-film hydration and ultrasonic treatment to obtain nanoliposomes; mixing the boric acid-modified hyaluronic acid with a polyvinyl alcohol solution, then adding the nanoliposome solution, and finally mixing to obtain the resulting nanohydrogel. The glucose-responsive nanohydrogel of this invention achieves adaptive drug release in the high glucose environment of diabetic wounds and regulates local metabolic homeostasis of the wound, especially the lysine degradation pathway in amino acid metabolism.

The invention discloses mucoprotein hydrogel loaded with cerium-dihydromyricetin nano-enzyme as well as a preparation method and application of the mucoprotein hydrogel, and relates to the technical field of biological medicines. The preparation method comprises the following steps: carrying out coordination reaction on dihydromyricetin and Ce < 4 + > to obtain cerium-dihydromyricetin nano-enzyme; the preparation method comprises the following steps: coupling hyaluronic acid with dopamine to obtain hyaluronic acid-dopamine; the preparation method comprises the following steps: coupling mucoprotein with aminophenylboronic acid to obtain mucoprotein-aminophenylboronic acid; the preparation method comprises the following steps: mixing cerium-dihydromyricetin nano-enzyme, hyaluronic acid-dopamine and mucoprotein-aminophenylboronic acid, and reacting, so as to obtain the mucoprotein hydrogel loaded with the cerium-dihydromyricetin nano-enzyme. The mucoprotein hydrogel loaded with the cerium-dihydromyricetin nano enzyme can be used for effectively treating ulcerative colitis and has an important clinical application value.

The invention belongs to the field of inorganic functional materials, and particularly relates to a basic nickel carbonate modified material and a preparation method thereof.The method comprises the steps that nickel nitrate hexahydrate is dissolved in deionized water, urea and cetyltrimethylammonium bromide are added, the mixture is heated and stirred mildly, and stirring is performed to obtain a basic nickel carbonate modified material; then adding a specially-made polyaminophenylboronic acid nickel complex and a cobalt-nickel phosphate ethanediamine hybrid material, performing ultrasonic dispersion to form a mixed solution, and then performing hydrothermal reaction, centrifugal washing and vacuum drying to obtain a final product. The two special modified compounds are respectively prepared through a coordination reaction regulated by ammonia water and a hybridization reaction under high-temperature and high-pressure conditions. The modified material prepared by the method has a unique microstructure and enhanced physical and chemical properties, shows excellent application prospects in the fields of electrochemical energy storage, electro-catalytic water and environmental remediation, and particularly, the comprehensive performance of the material is remarkably improved due to the high specific surface area, abundant active sites and a stable structure.

The present invention relates to the technical field of medical materials, and provides a smart hydrogel, a preparation method thereof, and an application thereof. The present invention introduces dopamine on the surface of TEMPO-oxidized nanocellulose, introduces 3-aminophenylboronic acid on the surface of oxidized dextran, and combines chitosan with polyvinyl alcohol to construct a hydrogel structure with a double cross-linked network based on Schiff base bonds and borate bonds. The present invention utilizes the characteristics of Schiff base bonds and borate bonds to enhance the mechanical properties of the hydrogel system; and due to the reversibility of Schiff base bonds and borate bonds, the smart hydrogel prepared by the present invention exhibits good self-repairing properties, further increasing the service life of the hydrogel; in addition, the smart hydrogel prepared by the present invention exhibits excellent antibacterial properties due to the presence of chitosan, which helps prevent bacterial infection at the wound site, thereby promoting wound repair, and has broad application prospects in the field of wound dressings.

The invention discloses a preparation method of a fast-charging electrolyte for a sodium-ion battery, and relates to the technical field of sodium-ion batteries. The specific preparation method comprises the following steps: mixing the main film-forming agent, the additive, the solvent and the sodium salt, and then performing ultrasonic dissolution to obtain the electrolyte. Fluoroethylene carbonate is used as a main film-forming agent and preferentially participates in the formation of a negative electrode solid electrolyte interface film, so that the interface impedance is reduced and the continuous decomposition of the electrolyte is inhibited; additives including triphenyl phosphate, isodecyl diphenyl phosphate, trineopentyl phosphate and 4-aminophenylboronic acid pinacol ester are introduced, so that a desolvation energy barrier of Na < + > at an interface is reduced, and a more stable and effective interface film is formed; propylene carbonate and methyl ethyl carbonate are used as solvents, so that the sodium ion transmission efficiency is ensured; high-concentration sodium salt is used for promoting formation of a solvation structure for anion aggregation; and finally, the button cell prepared from the prepared electrolyte can effectively support fast charging and has good electrochemical performance.

The invention relates to the field of biomedical materials, and particularly provides a preparation method of bioactive hydrogel for clinically retaining and slowly releasing medicine liniment.The preparation method comprises the following steps that S1, aminophenylboronic acid is dissolved in water to prepare an aminophenylboronic acid aqueous solution, a glucan derivative is added, after heating and stirring reaction, a product is collected, washed and dried, and the hydrogel is obtained; a hydrogel precursor is obtained; s2, polyphenol substances and polysaccharide substances are added into 0.5 wt%-20 wt% of an aqueous solution of the hydrogel precursor, after stirring reaction is conducted, 0.02 wt%-8 wt% of a hydrazide aqueous solution is added into the aqueous solution, ultrasonic treatment is conducted, standing is conducted, and the bioactive hydrogel can be obtained. By optimizing the variety and dosage of the components, the hydrogel can be attached to the skin, retention of the traditional Chinese medicine liniment at the focus of the skin is helped, and the action time of the liniment medicine is prolonged to 12-24 h.

This invention relates to the field of anti-corrosion reagent technology, specifically disclosing a method for manufacturing a solid oxygen-removing, bactericidal, corrosion-inhibiting, and scale-inhibiting agent for seawater oil well pipelines. The agent comprises a three-layer core-shell structure: the core layer is composed of a copolymer hydrogel of 2-acrylamido-2-methylpropanesulfonic acid and N-vinylcaprolactam, loaded with sodium isoascorbate and a copper-L-histidine complex; the middle layer is composed of 3-aminophenylboronic acid-functionalized silica nanoparticles and catechol linked by dynamic borate ester bonds; and the shell layer is composed of a copolymer of 3,4-dihydroxyphenylalanine and 1H,1H,2H,2H-perfluorodecyl acrylate coating a corrosion-inhibiting and bactericidal complex. This invention overcomes the pH conflict between oxygen removers and corrosion inhibitors in traditional reagents through the synergistic effect of the core-shell structure and dynamic bonds, achieving integrated functions of oxygen removal, bactericidal action, corrosion inhibition, and scale inhibition. It effectively inhibits microbial corrosion, reduces the risk of scaling, extends the lifespan of seawater pipelines, and is suitable for complex marine conditions.

The invention relates to the technical field of biomedical materials, in particular to double-responsiveness hydrogel as well as a preparation method and application thereof. The invention provides a dual-responsiveness injectable hydrogel. The dual-responsiveness injectable hydrogel comprises oxidized hyaluronic acid (OHA) and hyaluronic acid-3-aminophenylboronic acid (HA-PBA), the OHA and the HA-PBA are connected through a Schiff base bond; hA and PBA in the HA-PBA are connected through a boric acid ester bond. The hydrogel has ROS (reactive oxygen species) and pH (potential of hydrogen) double responsiveness due to existence of borate bonds and Schiff base bonds, and is suitable for being used as a carrier of a rheumatoid arthritis drug delivery system; hyaluronic acid is a main component of synovial fluid and is beneficial to relieving pain of a patient suffering from rheumatoid arthritis; the hydrogel is simple in used raw materials and simple and convenient in preparation process, and is expected to be applied to local drug delivery of rheumatoid arthritis and other pathological microenvironment diseases with high active oxygen or low pH.

The application discloses a CDs / GO-PBA nanocomposite probe synthesis and a Salmonella detection method. The method comprises the following steps: hydrothermal carbonization of mannose and histidine to obtain a pseudo-glycopeptide carbon dot, and then reaction of 3-aminophenylboronic acid and graphene oxide to obtain boronated modified graphene oxide GO-PBA. CDs are loaded on the GO-PBA sheet layer by forming a borate ester bond between the hydroxyl group and the boronic acid group, and CDs / GO-PBA with quenched fluorescence is obtained. The CDs / GO-PBA is added into a Salmonella typhimurium bacterial suspension, and after the CDs bind to the Salmonella typhimurium through the lectin-sugar interaction, the dynamic borate ester bond is broken, the CDs are separated from the graphene surface, and the fluorescence is restored. The concentration of the Salmonella typhimurium is detected by measuring the fluorescence intensity through a fluorescence spectrometer. The method can quickly and quantitatively detect the Salmonella typhimurium, and has good sensitivity and a wide detection range.

The invention belongs to the technical field of high-performance polyurethane elastomers, and discloses a super-strong and super-tough thermosetting polyurethane elastomer capable of being self-repaired and recycled as well as a preparation method and application of the super-strong and super-tough thermosetting polyurethane elastomer. Polycaprolactone is used as a soft segment, 4, 4 '-dicyclohexylmethane diisocyanate is used as a hard segment, dibutyltin dilaurate is used as a catalyst, oxalyl dihydrazine and carbohydrazide are used as chain extenders, and 3-aminophenylboronic acid is used for blocking, so that a polyurethane straight chain is generated through reaction; and carrying out vacuum drying and dehydration to obtain the super-strong and super-tough thermosetting polyurethane elastomer which has boric acid ester bonds and can be self-repaired and recycled. The polyurethane elastomer forms a double dynamic network of hydrogen bonds and boric acid ester bonds, dissociation and recombination under thermal stimulation can be achieved, and the self-repairing performance of the elastomer is achieved. Meanwhile, strong multiple hydrogen bond interaction is formed between the two hydrazide chain extenders, so that a sample is endowed with excellent energy dissipation capability, and excellent mechanical properties are achieved.

This invention discloses a sprayable bifunctional gel loaded with propolis extract, its preparation method, and its application. The method includes: synthesizing acetylated carboxymethyl chitosan using carboxymethyl chitosan and acetic anhydride as raw materials; reacting acetylated carboxymethyl chitosan and aminophenylboronic acid as raw materials to synthesize a boric acid-modified acetylated carboxymethyl chitosan gel precursor; blending the boric acid-modified acetylated carboxymethyl chitosan gel precursor with water, and self-assembling it into an A-CC-PBA hydrogel through hydrogen bonding and π-π bond interactions; and adding propolis extract to the A-CC-PBA hydrogel to obtain the final product. The gel prepared by this invention exhibits excellent adhesion properties, can stably remain in the oral ulcer site, and can efficiently target and slowly release drugs to achieve highly effective bactericidal and long-lasting anti-inflammatory effects, significantly improving the efficacy of oral ulcer treatment and providing a new formulation type for oral mucosal drug delivery.

The invention relates to the technical field of cell catalysts, in particular to a high-activity catalyst for a proton exchange membrane fuel cell and a preparation method of the high-activity catalyst. The preparation method comprises the following steps: firstly, carrying out pretreatment on Ti < 3 > C < 2 > T < x > MXene powder to obtain dispersion liquid; then reducing chloroplatinic acid and ferric nitrate through ascorbic acid by taking the nitrogen-doped carbon-coated platinum-iron alloy as a carrier, and carrying out high-temperature cracking in combination with dicyandiamide to generate a nitrogen-doped carbon-coated platinum-iron alloy in situ; loading iridium oxide on the surface through a hydrothermal method; and finally introducing ruthenium trichloride and phenanthroline, performing high-temperature pyrolysis to form a ruthenium-nitrogen coordination structure, and performing acid pickling, activation and 4-aminophenylboronic acid surface modification to obtain the final catalyst. Through MXene carrier optimization, multi-metal component collaboration and surface modification, the electrocatalytic activity and stability of the catalyst are remarkably improved, dependence on precious metal is reduced, and the catalyst is suitable for efficient operation of the proton exchange membrane fuel cell.

The invention discloses a preparation method of an epinephrine substance-loaded silk fibroin microneedle transdermal patch, which comprises the following steps: dissolving aminophenylboronic acid in a dimethyl sulfoxide aqueous solution to obtain an aminophenylboronic acid solution; adding the aminophenylboronic acid solution into a silk fibroin aqueous solution, then adding 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride and N-hydroxysuccinimide, and uniformly mixing to obtain a reaction solution; after the reaction of the reaction solution is finished, dialyzing to remove the small molecule catalyst and dimethyl sulfoxide to obtain a first mixed solution; the method comprises the following steps: dissolving an epinephrine substance in deionized water to obtain an epinephrine substance solution; adding the epinephrine substance solution into the first mixed solution, and uniformly mixing to obtain a second mixed solution; and casting the second mixed solution into a microneedle mold, defoaming, and drying to obtain the adrenaline substance-loaded silk fibroin microneedle transdermal patch.

This invention discloses a method for preparing a bilayer hydrogel microneedle patch loaded with nanomaterials, comprising: providing carbon nanotube particles loaded with calcium peroxide; grafting ferric tannate; grafting dihydroporphyrin E6 to obtain carbon nanotube particles loaded with calcium peroxide and grafted with dihydroporphyrin E6 and ferric tannate; dispersing the carbon nanotube particles loaded with calcium peroxide and grafted with dihydroporphyrin E6 and ferric tannate in a mixed solution composed of polyvinyl alcohol and polyvinylpyrrolidone to obtain a microneedle patch tip; providing sodium hyaluronate grafted with 3-aminophenylboronic acid; stirring the sodium hyaluronate grafted with 3-aminophenylboronic acid and polyvinyl alcohol solution on the microneedle patch tip to form a gel, thereby obtaining a bilayer hydrogel microneedle patch loaded with nanomaterials. This bilayer hydrogel microneedle patch loaded with nanomaterials can effectively achieve anti-tumor effects by directly delivering nanomaterials to the tumor site, promoting self-oxygenation within the tumor, and promoting tumor ablation.

This invention relates to the field of lithium battery technology, and more particularly to a preparation process for a lithium battery additive. The process first prepares a Zn-MOF-74 catalyst through dissolution, crystallization, separation, and stepwise vacuum drying. Then, using γ-valerolactone as a solvent, propenyl-1,3-sulfonyl lactone undergoes an addition reaction with 4-aminophenylboronic acid under the action of the catalyst to generate an intermediate. This intermediate then undergoes a substitution reaction with ethyl bromoethyl, followed by recrystallization and vacuum drying to obtain a sulfonate-boron-oxygen heterocyclic synergistic additive. This additive utilizes the synergistic effect of the sulfonate group and the boron-oxygen heterocycle to improve the ionic conductivity of the electrolyte and inhibit its decomposition, significantly improving the room-temperature cycle life, wide-temperature-range discharge performance, and high-temperature storage stability of lithium batteries. The preparation process is controllable, the product has high purity, and it is suitable for various high-performance lithium batteries.

This invention belongs to the field of lubricating oil additives, specifically relating to a soot-dispersible polyisobutylene succinimide dispersant, its preparation method, and its application. The preparation method includes the following steps: (1) mixing polyisobutylene maleic anhydride, base oil, and aromatic solvent, stirring evenly, heating, adding polyethylene polyamine, introducing nitrogen gas, heating to the aromatic reflux temperature, and performing an amidation reaction to obtain product 1; (2) adding aminophenylboronic acid to product 1, continuing reflux, borizing reaction, removing the solvent by vacuum distillation, filtering, and obtaining the soot-dispersible polyisobutylene succinimide dispersant. The dispersant in this invention has the characteristic of good soot dispersion performance. The prepared product can improve the soot dispersion of oil products with a lower dosage. Moreover, the use of aminophenylboronic acid for borization reaction can improve high-temperature detergency. The preparation process of this invention is simple and easy to implement.

This invention discloses a vascular occlusive gel composition, comprising a first component and a second component. The first component comprises cysteine-modified carboxymethyl cellulose and dopamine-modified carboxymethyl cellulose. The second component comprises 3-aminophenylboronic acid-modified carboxymethyl cellulose and hydroxyethyl methacrylate-modified carboxymethyl cellulose. This invention also discloses a vascular occlusive gel prepared from the above composition and its preparation method. This invention employs a two-component system that can rapidly crosslink to form a sealing hydrogel with excellent tissue adhesion, mechanical properties, and biocompatibility, effectively achieving physical occlusion of diseased blood vessels. Furthermore, all components exhibit good biocompatibility and biodegradability, ensuring medical safety.

The invention discloses injectable piezoelectric hydrogel for treating osteoarthritis as well as a preparation method and application of the injectable piezoelectric hydrogel. The injectable piezoelectric hydrogel is prepared from an oxidized chondroitin sulfate-3-aminophenylboronic acid polymer hydrogel matrix and piezoelectric nano particles dispersed in the polymer hydrogel matrix, the piezoelectric nano-particle comprises a core layer and a cartilage cell membrane layer, wherein the core layer is composed of biocompatible piezoelectric nano-particles, and the core layer is coated with the cartilage cell membrane layer. The surface of the cartilage cell membrane layer is conjugated with cartilage targeting peptide. The injectable piezoelectric hydrogel material provided by the invention has strong oxidation resistance, and meanwhile, piezoelectric-induced mitochondrial autophagy can reduce the generation of reactive oxygen species from the source, so as to synergistically protect cartilage cells.

Provided are a polypeptide, an anti-aging transdermal hydrogel, and a use, relating to the fields of biomedicine and novel drug development. The sequence of the polypeptide is (C12)-FGGRGGHGGGG-(3-Aminobenzeneboronic acid), wherein C12 represents lauric acid, 3-Aminobenzeneboronic acid represents 3-aminophenylboronic acid, F represents phenylalanine, G represents glycine, R represents arginine, and H represents histidine. The polypeptide can be chemically modified and self-assembled in an aqueous solution to form a supramolecular hydrogel. Experiments show that the polypeptide hydrogel has strong transdermal permeability, can reach the corium layer within2 h, can significantly inhibit aging phenotypes such as transcription of SASP factors, activation of P53, up-regulation of β-Gal, and expression of γH2AX, can be used for preparing anti-aging products, and has good market prospects and application potential.

The invention relates to the technical field of molecular fluorescence, in particular to a polarity-sensitive fluorescent probe based on ICT and a preparation method and application of the polarity-sensitive fluorescent probe. The preparation method of the polarity sensitive type fluorescent probe comprises the following steps: enabling 4, 7-dibromobenzo [c]-1, 2, 5-thiadiazole to react with [4-[bis (4-methoxyphenyl) amino] phenyl] boric acid to obtain 4-(7-bromo-2, 1, 3-benzothiadiazole-4-yl)-N, N-bis (4-methoxyphenyl) benzylamine, and enabling the 4, 7-dibromobenzo [c]-1, 2, 5-thiadiazole to react with [4-[bis (4-methoxyphenyl) amino] phenyl] boric acid to obtain 4-(7-bromo-2, 1, 3-benzothiadiazole-4-yl)-N, N-bis (4-methoxyphenyl) benzylamine. The preparation method comprises the following steps: enabling 4-(7-bromo-2, 1, 3-benzothiadiazole-4-yl)-N, N-bis (4-methoxyphenyl) benzylamine and (6-nitropyridine-3-yl) boric acid to react, so as to prepare the polarity sensitive type fluorescent probe. The polarity-sensitive fluorescent probe can be used as an effective tool for detecting the polarity change of the lipid droplet, and provides auxiliary diagnosis for diagnosis of some diseases related to the lipid droplet by dynamically monitoring the continuous process of the lipid droplet from generation to maturation to decomposition.

The invention discloses a fluoride-free environment-friendly high-cooling insulating fire extinguishing agent and a preparation method thereof, and belongs to the technical field of fire extinguishing agents. The fire extinguishing agent comprises an agent A and an agent B. The agent A comprises, by mass, 30-50 parts of a nonionic surfactant, 10-20 parts of a cosolvent, 5-15 parts of 3-aminophenylboronic acid modified cyclodextrin and 80-100 parts of deionized water. The agent B is prepared from the following raw materials in parts by mass: 0.6 to 1.2 parts of sodium bicarbonate, 2.5 to 3.5 parts of polyvinyl alcohol, 1.0 to 1.8 parts of tannic acid modified dopamine, 0.3 to 0.7 part of ammonium persulfate, 0.5 to 1.0 part of a cross-linking agent, 0.2 to 0.8 part of an insulating nano material and 200 to 300 parts of deionized water. The fluorine-free, high-cooling, insulating and anti-after-combustion comprehensive fire extinguishing agent adopts the A and B double-component form, is good in stability, and realizes the fluorine-free, high-cooling, insulating and anti-after-combustion comprehensive fire extinguishing effect through the combined action of multiple mechanisms.