147 results about "Aminophenylboronic acid" patented technology

The invention discloses a preparation method of injectable nano composite hydrogel for relieving osteoarthritis, which comprises the following steps: firstly, synthesizing nano rod-like hydroxyapatite with the length of 150-300 nm and the diameter of 10-15 nm, and the hydroxyapatite is hydrophilic hydroxyapatite doped with strontium and europium ions; the preparation method comprises the following steps: by taking Ca (NO3) 2, Sr (NO3) 2, Eu (NO3) 3 and soluble phosphate as main raw materials, carrying out hydrothermal reaction to prepare strontium and europium ion co-doped hydrophobic hydroxyapatite, dispersing the strontium and europium ion co-doped hydrophobic hydroxyapatite in a Tris-HCl buffer solution, adding tannic acid, stirring, centrifugally collecting precipitate, and drying to obtain strontium and europium ion doped hydrophilic hydroxyapatite; the preparation method comprises the following steps: taking chondroitin sulfate and adipic dihydrazide as main raw materials, stirring, dialyzing, freeze-drying, and dissolving in a buffer solution to obtain the chondroitin sulfate solution grafted with the hydrazide group; the preparation method comprises the following steps: taking hyaluronic acid, 3-aminophenylboronic acid and sodium periodate as main raw materials, stirring, dialyzing, freeze-drying, and dissolving in a buffer solution to obtain the phenylboronic acid group grafted oxidized hyaluronic acid solution; the preparation method comprises the following steps: blending hydrophilic hydroxyapatite doped with strontium and europium ions, a chondroitin sulfate solution grafted with a hydrazide group, an oxidized hyaluronic acid solution grafted with a phenylboronic acid group and a recombinant collagen solution, and stirring to obtain the injectable nano composite hydrogel. The injectable nano composite hydrogel obtained by the invention has good biocompatibility, and a favorable local immune microenvironment can be created to immunomodulate macrophages so as to relieve osteoarthritis and promote subchondral bone repair.

The invention discloses a UV photocureable coating as well as a preparation method and application thereof in automobiles, and relates to the technical field of coatings. When the UV photocureable coating is prepared, 4-aminophenylboronic acid is dehydrated to prepare aminated boron oxygen six-ring; carrying out a reaction on the aminated boroxane and diallyl chlorophosphate to prepare functionalized boroxane; the preparation method comprises the following steps: sequentially reacting graphene oxide with 3-chloropropyltriethoxysilane and 1, 3-diallyl-1, 3, 5-triazine-2, 4, 6-triketone, so as to obtain modified graphene; the preparation method comprises the following steps: reacting epoxy resin with 2-butenal thiosemicarbazone to prepare modified epoxy resin; and uniformly mixing the modified epoxy resin, the epoxy acrylate resin, the modified graphene, the functionalized boroxane, the 1, 6-hexanediol diacrylate and the 1-hydroxycyclohexyl phenyl ketone, so as to obtain the UV photocureable coating. The UV photocureable coating prepared by the invention has excellent flame retardant, self-repairing and mechanical properties.

The invention discloses a sunlight response high-strength self-repairing polyurethane material and a preparation method thereof, and belongs to the technical field of self-repairing materials, the sunlight response high-strength self-repairing polyurethane material is obtained by coordinating polyurethane containing an azothiazole structure and metal ions according to a certain proportion, the polyurethane containing the azothiazole structure is prepared by stirring diisocyanate, diol containing the azothiazole structure, long-chain diol and aminophenylboronic acid according to a certain proportion in N, N-dimethylformamide at room temperature to react for 5 hours. According to the invention, a photoactive azothiazole structure is introduced into polyurethane, and reversible metal coordination bonds are formed by the azothiazole structure and metal ions, so that rapid sunlight response self-repairing of the polyurethane material is realized. The self-repairing efficiency of the prepared photoresponse self-repairing polyurethane material is 95.1% after the photoresponse self-repairing polyurethane material is irradiated by sunlight for 2 h, and the photoresponse self-repairing polyurethane material has rapid photoresponse self-repairing performance and has wide application prospects in the fields of self-repairing coatings, intelligent coatings and anti-corrosion coatings.

The invention relates to the field of heat shrinkage films, in particular to an antistatic PETG heat shrinkage film. The PETG heat shrink film comprises the following components in parts by weight: 100 parts of PETG resin, 2-6 parts of an anti-adhesion agent, 2-5 parts of a lubricant, 1-5 parts of an antistatic modifier, 1-2 parts of an antioxidant and 0.5-1 part of a light stabilizer. In the preparation process of the PETG heat shrink film, a novel borate antistatic agent is introduced, and the antistatic agent is synthesized by taking tris (2-carboxyethyl) isocyanurate and 4-aminophenylboronic acid pinacol ester as raw materials, so that compared with a traditional antistatic agent, the antistatic property is better, the heat stability is obviously improved, and the service life of the heat shrink film is prolonged. And the phenomenon of local deformation or poor arc-shaped shrinkage of the PETG heat shrinkage film when the PETG heat shrinkage film shrinks at a non-uniform interface is reduced.

The invention discloses a vegetable oil-based room-temperature water-induced self-healing polyurethane elastomer and a preparation method thereof. The elastomer is prepared by taking polytetramethylene ether glycol and tung oil glycol as soft segments, isophorone diisocyanate as a hard segment, dimethylolpropionic acid as a hydrophilic chain extender and 3-aminophenylboronic acid as an end-capping reagent. Polytetramethylene ether glycol and tung oil glycol are used as soft segments, isophorone diisocyanate is used as a hard segment, dimethylolpropionic acid is used as a hydrophilic chain extender, 3-aminophenylboronic acid is used for blocking, then triethylamine is used for neutralization, and a waterborne polyurethane material with high-density crosslinking sites is synthesized. The material has good mechanical properties and fracture toughness, the tensile strength of the polyurethane film can reach 6.94 MPa, the elongation at break can reach 790.1%, and the film has good rebound resilience.

The invention discloses a double-response collagen-based conductive hydrogel, a medicine and a preparation and application method of the double-response collagen-based conductive hydrogel. The preparation method of the double-response collagen-based conductive hydrogel comprises the following steps: carrying out chemical modification on polysaccharide through 3-aminophenylboronic acid, and then carrying out sodium periodate oxidation treatment to obtain a dialdehyde polysaccharide grafted aminophenylboronic acid copolymer; the preparation method comprises the following steps: performing hydrazide modification on collagen through adipic acid dihydrazide, and performing free radical polymerization with aniline to obtain a hydrazide collagen grafted polyaniline copolymer; the dialdehyde polysaccharide grafted aminophenylboronic acid copolymer and the hydrazide collagen grafted polyaniline copolymer are subjected to crosslinking, and the double-response collagen-based conductive hydrogel capable of responding to glucose and the pH value is obtained. Compared with single-response conductive hydrogel, the hydrogel can specifically respond to the microenvironment of chronic diabetic wound surfaces and release antibacterial and anti-inflammatory drugs, and high-quality healing of chronic wounds such as diabetic foot ulcers and the like is promoted.

The invention relates to the technical field of abdominal wall adhesion materials induced by prevention and treatment of bacterial infection, and discloses an ionic liquid-based antibacterial-anti-inflammatory integrated bioactive nanoparticle with microwave sensitivity, a preparation method and application of the ionic liquid-based antibacterial-anti-inflammatory integrated bioactive nanoparticle. Then, the surfaces of the hollow nano particles are modified with bacteria specific targeting molecule 3-aminophenylboronic acid, and PBA-HPDA is formed; finally, chlorogenic acid and quaternary ammonium salt are combined according to a certain proportion to form ionic liquid (ILs) with a microwave heat effect, the ionic liquid (ILs) is wrapped in HPDA, and composite nanoparticles PBA-HPDA-CAQAC are formed. The nano particle material prepared by the invention has microwave heat effect and antibacterial and anti-inflammatory integrated biological activity, and has excellent bactericidal and anti-inflammatory effects.

The invention discloses a preparation method of recombinant collagen nano-composite hydrogel for repairing wounds infected by multiple drug-resistant bacteria, which comprises the following steps: binding copper porphyrin pi-pi on titanium carbide nanosheets to form MXene coated CuTCPP nanoparticles, and carrying out amidation reaction on 3-aminophenylboronic acid and recombinant collagen to obtain the recombinant collagen nano-composite hydrogel for repairing wounds infected by multiple drug-resistant bacteria. MXene coated CuTCPP is doped into a modified recombinant collagen system and mixed with a polyvinyl alcohol solution, and the recombinant collagen nano-composite hydrogel is prepared. The self-healing property endowed by the dynamic cross-linking characteristic of the phenylboronic acid ester bond in the composite hydrogel disclosed by the invention can be highly adapted to irregular wounds; the nano particles with the heterojunction structure can be combined with photothermal therapy and photodynamic therapy to efficiently sterilize wounds; the hydrogel has the antibacterial property and the property of promoting wound healing, and can comprehensively and efficiently treat wounds infected by multiple drug-resistant bacteria.

The invention belongs to the field of biomedical materials, and discloses a composite hydrogel dressing and application. The composite hydrogel dressing is prepared by the following steps: blending 4-aminophenylboronic acid grafted hyaluronic acid and gallic acid grafted collagen, adjusting the pH value, carrying out a cross-linking reaction to obtain a cross-linking product, and stirring and mixing the cross-linking product with a gallic acid reduced silver nanoparticle solution. The antibacterial and self-healing composite hydrogel dressing for promoting wound repair has proper adhesion, mechanical properties and free radical scavenging ability, and excellent antibacterial property, biocompatibility and self-healing ability.

The invention relates to the technical field of corrosion inhibitors, and discloses a preparation method of a modified imidazoline corrosion inhibitor, which comprises the following steps: carrying out quaternization reaction on tertiary amine group in an imidazoline intermediate and chlorine in benzyl chloride to generate quaternary ammonium salt, introducing hydroxyl, and continuing to carry out esterification reaction with boric acid group in 4-aminophenylboronic acid to obtain the modified imidazoline corrosion inhibitor. The modified imidazoline corrosion inhibitor is prepared by the following steps of: firstly, introducing amino groups, then carrying out amidation reaction with acyl chloride groups in 4-vinyl benzoyl chloride, introducing alkenyl groups, and finally carrying out click reaction with sulfydryl groups in DSB-TA, so as to generate the modified imidazoline corrosion inhibitor. The modified imidazoline corrosion inhibitor disclosed by the invention has a relatively good corrosion inhibition effect.

The invention belongs to the technical field of preparation and application of nano materials, and relates to a preparation method and application of amino-functionalized cerium oxide nano enzyme, and the preparation method comprises the following steps: adding 3-aminophenylboronic acid into a cerous nitrate hexahydrate aqueous solution to obtain a mixed solution; dropwise adding a sodium hydroxide aqueous solution into the mixed solution, carrying out hydrothermal reaction, cooling after the reaction is finished, centrifuging, washing and drying to obtain milk white powder, namely the amino-functionalized cerium oxide nano-enzyme. The boron element is introduced in the preparation of the cerium oxide nano-enzyme, and the amino-functionalized cerium oxide nano-enzyme is prepared by adopting a simple one-step hydrothermal synthesis method, so that the nano-enzyme has good phosphatase-like activity, has high selectivity and sensitivity to LPS, and is short in detection time, high in sensitivity, low in detection limit, simple in preparation process and high in preparation efficiency; the product is good in quality, high in stability, environment-friendly and extremely wide in market prospect.

The invention discloses a propolis extract-loaded sprayable bifunctional gel as well as a preparation method and application thereof. The preparation method comprises the following steps: synthesizing acetylated carboxymethyl chitosan by taking carboxymethyl chitosan and acetic anhydride as raw materials; the preparation method comprises the following steps: reacting acetylated carboxymethyl chitosan and aminophenylboronic acid serving as raw materials to synthesize a boric acid modified acetylated carboxymethyl chitosan gel precursor; the preparation method comprises the following steps: blending a boric acid modified acetylated carboxymethyl chitosan gel precursor with water, and self-assembling into A-CC-PBA hydrogel under the action of a hydrogen bond and a pi-pi bond; and adding the propolis extract into the A-CC-PBA hydrogel, so as to obtain the A-CC-PBA hydrogel. The gel prepared by the invention has good adhesion performance, can stably retain in the local part of the oral ulcer and can realize efficient targeted recognition and slow release of drugs to realize efficient sterilization and long-acting anti-inflammatory effects, the curative effect on the oral ulcer is obviously improved, and a new preparation type is provided for oral mucosa administration.

The invention relates to the field of pouring sealants, and discloses a modified epoxy resin pouring sealant and a preparation method thereof, the pouring sealant comprises epoxy resin, a modified inorganic filler, a modified additive and an auxiliary agent; the modified inorganic filler is prepared by grafting a quaternized s-triazine derivative and an inorganic filler; the quaternized s-triazine derivative is prepared through the steps that 3, 5-diaminophenylboronic acid, cyanuric chloride, 3-chloropropyltrimethoxysilane and 1, 4-butanediamine are sequentially subjected to substitution to prepare a s-triazine derivative, then the s-triazine derivative reacts with N, N-dimethyl-1, 3-diaminopropane, and bromoethane is used for quaternization treatment. The modified additive is prepared from a modified bismaleimide monomer prepared from maleic anhydride and 5 (6)-amino-1-(4-aminophenyl)-1, 3, 3-trimethylindane and 1-methyl-4-isopropyl cyclohexene through a self-stabilization precipitation polymerization method, the prepared pouring sealant is high in tensile strength, good in impact resistance and good in mechanical property, and the prepared pouring sealant has the advantages of being good in mechanical property, good in mechanical property and good in mechanical property. Meanwhile, good heat resistance, flame retardance, dielectricity and antibacterial activity are achieved.

The invention discloses fluorine-containing bio-based epoxy resin as well as a preparation method and application thereof, and relates to the technical field of high polymer materials. The preparation method of the fluorine-containing bio-based epoxy resin comprises the following steps: enabling octafluoropentyloxy glycidyl ether as a fluorine unit to react with dihydric alcohol to obtain fluorine-terminated side chain butanediol, enabling the fluorine-terminated side chain butanediol to react with isocyanate to obtain a polyurethane prepolymer, and performing boric acid end capping on the polyurethane prepolymer by using 3-aminophenylboronic acid to obtain the fluorine-containing bio-based epoxy resin. The fluorine-containing bio-based epoxy resin (FBPU-ER) is prepared by the following steps: adding fluorine-containing polyurethane resin and phenylboronic acid into epoxidized soybean oil to obtain phenylboronic acid modified fluorine-containing polyurethane resin (FBPU), carrying out boric acid treatment on the epoxidized soybean oil by using 3-aminophenylboronic acid to obtain phenylboronic acid modified epoxy resin (BER), and finally, mixing the phenylboronic acid modified fluorine-containing polyurethane resin and the phenylboronic acid modified epoxy resin to obtain the fluorine-containing bio-based epoxy resin (FBPU-ER). The fluorine-containing bio-based epoxy resin prepared through fluorine-containing modification and toughening design has good mechanical properties, stability and self-repairing performance.

The invention relates to the technical field of microneedle preparation, and discloses a microneedle patch for wound repair and a preparation method thereof. The microneedle patch includes: a microneedle substrate; the microneedle is arranged on the surface of the microneedle substrate; the microneedle comprises a cross-linked body and polydopamine nanoparticles which are coated by the cross-linked body and are modified by lysine, the cross-linked body is obtained by cross-linking sodium alginate grafted with 3-aminophenylboronic acid and methacrylated hyaluronic acid. The microneedle patch for wound healing provided by the invention has a glucose response function, can automatically adjust the release amount according to the wound environment, and realizes long-acting and accurate wound nursing. And the microneedle patch also has antibacterial and antioxidant effects.

The invention discloses an H-aggregation type I photosensitizer as well as a preparation method and application thereof. The structural formula of the H-aggregation type I photosensitizer disclosed by the invention is # imgabs0. The H-aggregation type I photosensitizer disclosed by the invention is characterized in that aminophenylboronic acid and 5-bromothieno [3, 2-b] thiophene-2-formaldehyde are subjected to a reaction to obtain an intermediate product NBSCHO, and the NBSCHO and 3-(dicyanomethylene) indanone IC are subjected to a reaction to obtain the H-aggregation type I photosensitizer. The photosensitizer disclosed by the invention has a D-pi-A type molecular structure, and due to a well-designed plane characteristic between a pi structure and an A structure, the photosensitizer has relatively strong pi-pi accumulation capacity, and formation of H-aggregation accumulation of the photosensitizer is driven, so that the active oxygen generation effect of molecules, especially generation of I type active oxygen, is improved. The material can efficiently generate I-type active oxygen under the irradiation of white light or near-infrared laser, so that tumor cells are efficiently killed, and an efficient photodynamic therapy effect is shown.

The invention discloses ROS (reactive oxygen species) sensitive hydrogel as well as a preparation method and application thereof. The ROS sensitive hydrogel disclosed by the invention is prepared from aminophenylboronic acid, N-hydroxysuccinimide, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, hyaluronic acid, tannic acid and water. On the basis of ROS-sensitive dynamic boric acid ester bonds, aminophenylboronic acid modified HA (HA-PB) and tannic acid are mixed to prepare the hydrogel (HT). And adding a PVA (Polyvinyl Alcohol) solution into the HT hydrogel to obtain the hydrogel HTP. In the preparation process of the HTP hydrogel, the L.reuterii is added, so that the L.reuterii coated HTP hydrogel can be obtained. The hydrogel disclosed by the invention has excellent biological safety and degradability, the hydrogel can efficiently release TA to relieve an oxidative stress reaction due to ROS responsive degradation at an inflammation part, and HA released during degradation is also beneficial to repair of damaged gastric mucosa. More importantly, the homeostasis of intestinal flora is not influenced by using the therapy.

The invention belongs to the technical field of electrochemical sensors, and particularly relates to a miniature electrochemical sensor and a preparation method and application thereof. The miniature electrochemical sensor is a sensor based on a surface molecularly imprinted polymer and an acupuncture needle; the preparation method comprises the following steps: sequentially electrodepositing gold nanoparticles, multi-walled carbon nanotubes, polyferulic acid and gold nanoparticles on an acupuncture needle, incubating in a 4-mercaptophenylboronic acid solution, incubating in a vascular endothelial growth factor protein solution, sequentially electrodepositing poly (3-aminophenylboronic acid) and polychrome black T, and finally eluting the vascular endothelial growth factor protein to obtain the vascular endothelial growth factor. A specific imprinting cavity which is complementarily matched with the molecular structure of the vascular endothelial growth factor protein is formed. According to the invention, polyferulic acid is taken as an electroactive signal source, 3-aminophenylboronic acid and chrome black T are taken as functional monomers, an acupuncture needle sensing platform of a molecularly imprinted polymer is prepared through electrodeposition polymerization, a recognition sensing interface is formed, and high selectivity and high sensitivity are shown on vascular endothelial growth factors.

The invention discloses a cartilage repair hydrogel material and a preparation method thereof, and relates to the technical field of biomedical materials. The preparation method comprises the following steps: adding a vitamin E water-soluble derivative D-alpha-tocopherol polyethylene glycol 1000 succinate, T-ZIF-8 modified by 2, 4-toluene diisocyanate and Mg-MOF modified by SIKVAV peptide into a mixed solution obtained by compounding silk fibroin peptide, oxidized chondroitin sulfate and 3-aminophenylboronic acid, and carrying out crosslinking under ultraviolet light, so as to obtain the cartilage repair hydrogel material. The hydrogel material prepared by the method has a three-dimensional complex cross-linked structure and is high in mechanical property and stability; through the synergistic effect of the components, an adhesion group and a hydrophilic group are created for the surface of the hydrogel material, the binding opportunity of bone cells and the surface of the hydrogel material is increased, adhesion and proliferation of the bone cells are promoted, rejection reaction of tissues to metal materials is reduced, inflammatory reaction is reduced, and collagen secretion and cartilage regeneration are promoted.

The invention discloses a responsive dynamic hydrogel preparation method, which comprises: 1, dispersing sodium alginate, carrying out a directional oxidation reaction on the dispersed sodium alginate and a sodium periodate aqueous solution to obtain aldehyde group-containing oxidized sodium alginate, and dissolving the aldehyde group-containing oxidized sodium alginate in a hot solution of polyvinyl alcohol to obtain a precursor mother solution A; 2, dissolving a water-soluble chitosan derivative in deionized water, adding aminophenylboronic acid small molecules, and heating to obtain a precursor mother solution B; 3, uniformly mixing the precursor mother liquor A and the precursor mother liquor B to obtain dynamic hydrogel; the preparation method comprises the following steps: coating a precursor mother solution A on a medical material matrix, and then coating the precursor mother solution B on the medical material matrix. According to the invention, an aldehyde group and an amido group form imine bond cross-linking, and a phenylboronic acid group and vicinal diol form boric acid ester bond cross-linking, so that the prepared hydrogel has rapid gelling ability, pH and ROS responsiveness and proper elastic modulus; after the hydrogel disclosed by the invention is applied to a medical material matrix, the biological responsiveness and the interface mechanical softness of the medical material matrix are improved.

An N-heterocycle-containing boric acid compound and a preparation method and application thereof are provided. The preparation method adopts 3-bromo-1-p-tosyl-1H-pyrrolo[2, 3-b]pyrimidine as a raw material to generate (3-((5-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)boric acid by three steps of reaction. The (3-((5-chloro-4 (1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)boric acid has good inhibition effect on the proliferation activity of brain glioma, which is proven by cell experiments.

The invention discloses a method for preparing a fluorescent probe of plasma enhanced fluorescence and its application in ellagic acid detection, wherein anhydrous ethanol, TEOS and ammonia are reacted in a gold nanoparticle solution to obtain silicon dioxide gold nanoparticles, and reacted with APTMS to obtain amino-modified silicon dioxide-wrapped gold nanoparticles; sodium citrate, 3-APTES and glycerol are reacted to obtain a silicon dot solution, citric acid, EDC and NHS are added to form citric acid-modified silicon dots, and then reacted with EDC, NHS and amino-modified silicon dioxide-wrapped gold nanoparticle solution to obtain a silicon dot-modified gold nanoparticle solution on the surface of silicon dioxide; 3-aminophenylboronic acid, EDC and NHS are then added to react to obtain a fluorescent probe of plasma enhanced fluorescence. The fluorescent probe of plasma enhanced fluorescence prepared by the present invention has good stability, strong specificity and high sensitivity, and can be used for quantitative detection of ellagic acid and is more efficient, cost-saving and more accurate.

The invention discloses oxidized sodium alginate / polyvinyl alcohol fluorescent hydrogel capable of rapidly gelling as well as a preparation method and application of the oxidized sodium alginate / polyvinyl alcohol fluorescent hydrogel, and belongs to the technical field of hydrogel preparation. The preparation method provided by the invention comprises the following steps: adding sodium periodate into a sodium alginate aqueous solution for oxidation, dialyzing and drying to obtain oxidized sodium alginate; dissolving oxidized sodium alginate in water, adding aminophenylboronic acid and an activating agent, and reacting to obtain a phenylboronic acid-based oxidized sodium alginate solution; and mixing the phenylboronic acid-based oxidized sodium alginate solution with the polyvinyl alcohol solution, and stirring for 8-20 seconds to obtain the water treatment agent. The preparation method disclosed by the invention is simple and convenient, very rapid in gel forming, low in equipment cost and suitable for large-scale preparation; the prepared hydrogel is excellent in swelling property, and emits blue light under ultraviolet irradiation; meanwhile, the property is stable, the pH response and active oxygen response characteristics are achieved, self-healing can be achieved, and good application prospects are achieved in the fields of tissue repair and fluorescent falsification prevention.

The invention discloses ROS (reactive oxygen species) responsive hydrogel loaded with hypoxia-induced exosome as well as a preparation method and application of the ROS responsive hydrogel. The ROS responsive hydrogel comprises an ROS responsive hydrogel matrix and a hypoxia-induced exosome dispersed in the ROS responsive hydrogel matrix, and the ROS responsive hydrogel matrix is prepared by uniformly mixing hyaluronic acid grafted with 3-aminophenylboronic acid and epsilon-polylysine grafted with caffeic acid. Under a high ROS environment, boric acid ester bonds in the hydrogel can be destroyed to release exosomes and caffeic acid, and the exosomes induced by hypoxia contain more factors for promoting tissue repair and regeneration and also have the competitive advantage of high uptake rate. The ROS responsive hydrogel loaded with the hypoxia-induced exosome can realize on-demand release of the exosome, delivers the exosome with endogenous competitive advantages to an ischemic infarction region and removes excessive active oxygen to play a role in efficiently repairing myocardial infarction.

This invention discloses a hyaluronic acid-phenylboronic acid-methotrexate antitumor conjugate and its preparation method in the field of drug preparation technology. First, hyaluronic acid is activated with carboxylic acid, then subjected to an amidation reaction with 3-aminophenylboronic acid to obtain a hyaluronic acid-phenylboronic acid conjugate. Next, methotrexate is activated and added to the hyaluronic acid-phenylboronic acid mixture, followed by stirring to obtain the hyaluronic acid-phenylboronic acid-methotrexate antitumor conjugate. The preparation method of this invention is simple. While the three drugs exert their respective effects, the introduction of phenylboronic acid enhances the targeted antitumor effect of the drug. The combined use of hyaluronic acid and phenylboronic acid further reduces the toxic side effects of methotrexate and improves the biocompatibility, bioavailability, and degradability of the resulting drug, making it suitable for application in the preparation of antitumor drugs.

The invention relates to the technical field of biopolymer materials, and particularly discloses pH response hydrogel as well as a preparation method and application thereof. The pH response hydrogel comprises a hydrogel matrix and a pH response material, wherein the hydrogel matrix comprises carboxymethyl chitosan N-hydroxymethyl acrylamide and 3-aminophenylboronic acid covalently connected with the carboxymethyl chitosan N-hydroxymethyl acrylamide; the loading particle comprises a polydopamine particle and an insulin-like growth factor 1 loaded on the polydopamine particle; wherein the covalently connected covalent bond is a boric acid ester bond, and the loaded particles are uniformly dispersed in the hydrogel matrix. According to the invention, carboxymethyl chitosan N-hydroxymethacrylamide and 3-aminophenylboronic acid are covalently connected through a borate bond, so that the pH response hydrogel is rapidly cured under ultraviolet irradiation and is attached to a specific periodontal tissue inflammation area, and the borate bond is decomposed in an inflammation acid environment; the insulin-like growth factor 1 is quickly released in an inflammation region, so that periodontitis is relieved, and periodontal bone tissue regeneration is promoted.

The invention provides a quantum dot doped reduced graphene oxide film and a preparation method thereof, and belongs to the technical field of composite materials. The preparation method comprises the following steps: heating citric acid, phytic acid and 3-aminophenylboronic acid to react to prepare P / B / N co-doped graphene quantum dots, loading a lanthanum element, modifying the surface by a silane coupling agent with an epoxy group, reacting with an aniline tetramer to prepare a compound, adding the compound into a graphene oxide aqueous dispersion, carrying out suction filtration, soaking in a potassium iodide-hydrochloric acid solution, heating, carrying out a sealed reaction, and washing to obtain the lanthanum-doped graphene quantum dots. And drying to obtain the quantum dot doped reduced graphene oxide film. The quantum dot-doped reduced graphene oxide film prepared by the method has relatively good hydrophilicity and conductivity, so that the degree of order of the film is improved, the wet-induced power generation performance is improved, the performance is not attenuated after long-time operation, the service life and the storage life are long, and the quantum dot-doped reduced graphene oxide film has a wide application prospect.

The invention belongs to the technical field of biomedical materials and biomedical engineering, and discloses peach gum-based self-repairing moisturizing hydrogel, a preparation method and application of the peach gum-based self-repairing moisturizing hydrogel in hemostasis and moisturizing materials. The preparation method comprises the following steps: carrying out an amide reaction on 3-aminophenylboronic acid hydrochloride (3APBA), and grafting the 3-aminophenylboronic acid hydrochloride (3APBA) on purified peach gum to obtain boronic acid peach gum (PR-3APBA); and adding an efficient humectant sodium pyrrolidone carboxylate, and freeze-drying to obtain the self-repairing hemostatic moisturizing gel. The adhesive has excellent hemostasis, moisturizing and self-repairing functions, is applied to body surface skin wound repair, and particularly has better wound repair performance and tissue adhesion performance when being used as an adhesion hemostasis material.

The invention discloses a protamine derivative and application thereof, the protamine derivative is obtained by modifying phenylboronic acid on a protamine side chain amino group, and the phenylboronic acid is selected from 4-carboxyphenylboronic acid, 2-aminophenylboronic acid, 3-carboxyl-4-fluorophenylboronic acid or 4-formyl chlorophenylboronic acid; the protamine derivative can be combined with a nucleic acid drug through a boric acid group and is used as a delivery carrier for preparing a nucleic acid drug delivery system. The invention provides a preparation scheme of phenylboronic acid modified protamine, the phenylboronic acid modified protamine is applied to nucleic acid drug delivery, after phenylboronic acid is modified, a boric acid ester bond is formed between a carrier and nucleic acid, and the nucleic acid drug can be responsively released in a high-concentration ATP environment. The functional modified protamine obviously improves the stability of a nucleic acid delivery system, enables the release of a nucleic acid drug to be controllable, and enhances the curative effect of gene therapy.

The invention discloses a trithiophene type fluorescent probe for detecting total polar substances of edible oil as well as a preparation method and application of the trithiophene type fluorescent probe. The preparation method comprises the following steps: directly carrying out a coupling reaction on 4-bis (4-methoxyphenyl) amino] phenyl]-[2, 2 ': 5', 2 ''-trithiophene-5-formaldehyde and 4-bis (4-methoxyphenyl) aminophenylboronic acid to prepare 5''-[4-[bis (4-methoxyphenyl) amino] phenyl]-[2, 2 ': 5', 2 ''-trithiophene-5-formaldehyde, and reacting the compound with 4-methylquinoline to synthesize the probe (E)-4-methoxy-N-(4-methoxyphenyl)-N-[4-(5''-(2-(quinoline-4-yl) vinyl)-[2, 2 ': 5', 2 ''-trithiophene-5-formaldehyde. The compound can selectively detect the polarity of edible oil, yellow fluorescence is quenched after the polarity of the edible oil is increased, and the compound can be used as a fluorescent probe for detecting the polarity of the edible oil.