42 results about "Aminophenylboronic acid" patented technology

The invention relates to the field of pouring sealants, and discloses a modified epoxy resin pouring sealant and a preparation method thereof, the pouring sealant comprises epoxy resin, a modified inorganic filler, a modified additive and an auxiliary agent; the modified inorganic filler is prepared by grafting a quaternized s-triazine derivative and an inorganic filler; the quaternized s-triazine derivative is prepared through the steps that 3, 5-diaminophenylboronic acid, cyanuric chloride, 3-chloropropyltrimethoxysilane and 1, 4-butanediamine are sequentially subjected to substitution to prepare a s-triazine derivative, then the s-triazine derivative reacts with N, N-dimethyl-1, 3-diaminopropane, and bromoethane is used for quaternization treatment. The modified additive is prepared from a modified bismaleimide monomer prepared from maleic anhydride and 5 (6)-amino-1-(4-aminophenyl)-1, 3, 3-trimethylindane and 1-methyl-4-isopropyl cyclohexene through a self-stabilization precipitation polymerization method, the prepared pouring sealant is high in tensile strength, good in impact resistance and good in mechanical property, and the prepared pouring sealant has the advantages of being good in mechanical property, good in mechanical property and good in mechanical property. Meanwhile, good heat resistance, flame retardance, dielectricity and antibacterial activity are achieved.

An N-heterocycle-containing boric acid compound and a preparation method and application thereof are provided. The preparation method adopts 3-bromo-1-p-tosyl-1H-pyrrolo[2, 3-b]pyrimidine as a raw material to generate (3-((5-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)boric acid by three steps of reaction. The (3-((5-chloro-4 (1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)boric acid has good inhibition effect on the proliferation activity of brain glioma, which is proven by cell experiments.

The invention discloses ROS (reactive oxygen species) responsive hydrogel loaded with hypoxia-induced exosome as well as a preparation method and application of the ROS responsive hydrogel. The ROS responsive hydrogel comprises an ROS responsive hydrogel matrix and a hypoxia-induced exosome dispersed in the ROS responsive hydrogel matrix, and the ROS responsive hydrogel matrix is prepared by uniformly mixing hyaluronic acid grafted with 3-aminophenylboronic acid and epsilon-polylysine grafted with caffeic acid. Under a high ROS environment, boric acid ester bonds in the hydrogel can be destroyed to release exosomes and caffeic acid, and the exosomes induced by hypoxia contain more factors for promoting tissue repair and regeneration and also have the competitive advantage of high uptake rate. The ROS responsive hydrogel loaded with the hypoxia-induced exosome can realize on-demand release of the exosome, delivers the exosome with endogenous competitive advantages to an ischemic infarction region and removes excessive active oxygen to play a role in efficiently repairing myocardial infarction.

This invention discloses a hyaluronic acid-phenylboronic acid-methotrexate antitumor conjugate and its preparation method in the field of drug preparation technology. First, hyaluronic acid is activated with carboxylic acid, then subjected to an amidation reaction with 3-aminophenylboronic acid to obtain a hyaluronic acid-phenylboronic acid conjugate. Next, methotrexate is activated and added to the hyaluronic acid-phenylboronic acid mixture, followed by stirring to obtain the hyaluronic acid-phenylboronic acid-methotrexate antitumor conjugate. The preparation method of this invention is simple. While the three drugs exert their respective effects, the introduction of phenylboronic acid enhances the targeted antitumor effect of the drug. The combined use of hyaluronic acid and phenylboronic acid further reduces the toxic side effects of methotrexate and improves the biocompatibility, bioavailability, and degradability of the resulting drug, making it suitable for application in the preparation of antitumor drugs.

This invention provides the application of glucose-responsive nanohydrogels in the preparation of drugs for treating skin injuries. The method includes the following steps: mixing hyaluronic acid with a phenylboronic acid compound, adding 3-aminophenylboronic acid, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride and N-hydroxysuccinimide, and performing a grafting reaction to obtain boric acid-modified hyaluronic acid; adding myricetin-3-O-galactoside, phospholipids, and cholesterol to an organic solvent, followed by thin-film hydration and ultrasonic treatment to obtain nanoliposomes; mixing the boric acid-modified hyaluronic acid with a polyvinyl alcohol solution, then adding the nanoliposome solution, and finally mixing to obtain the resulting nanohydrogel. The glucose-responsive nanohydrogel of this invention achieves adaptive drug release in the high glucose environment of diabetic wounds and regulates local metabolic homeostasis of the wound, especially the lysine degradation pathway in amino acid metabolism.

The invention discloses mucoprotein hydrogel loaded with cerium-dihydromyricetin nano-enzyme as well as a preparation method and application of the mucoprotein hydrogel, and relates to the technical field of biological medicines. The preparation method comprises the following steps: carrying out coordination reaction on dihydromyricetin and Ce < 4 + > to obtain cerium-dihydromyricetin nano-enzyme; the preparation method comprises the following steps: coupling hyaluronic acid with dopamine to obtain hyaluronic acid-dopamine; the preparation method comprises the following steps: coupling mucoprotein with aminophenylboronic acid to obtain mucoprotein-aminophenylboronic acid; the preparation method comprises the following steps: mixing cerium-dihydromyricetin nano-enzyme, hyaluronic acid-dopamine and mucoprotein-aminophenylboronic acid, and reacting, so as to obtain the mucoprotein hydrogel loaded with the cerium-dihydromyricetin nano-enzyme. The mucoprotein hydrogel loaded with the cerium-dihydromyricetin nano enzyme can be used for effectively treating ulcerative colitis and has an important clinical application value.

The invention belongs to the field of inorganic functional materials, and particularly relates to a basic nickel carbonate modified material and a preparation method thereof.The method comprises the steps that nickel nitrate hexahydrate is dissolved in deionized water, urea and cetyltrimethylammonium bromide are added, the mixture is heated and stirred mildly, and stirring is performed to obtain a basic nickel carbonate modified material; then adding a specially-made polyaminophenylboronic acid nickel complex and a cobalt-nickel phosphate ethanediamine hybrid material, performing ultrasonic dispersion to form a mixed solution, and then performing hydrothermal reaction, centrifugal washing and vacuum drying to obtain a final product. The two special modified compounds are respectively prepared through a coordination reaction regulated by ammonia water and a hybridization reaction under high-temperature and high-pressure conditions. The modified material prepared by the method has a unique microstructure and enhanced physical and chemical properties, shows excellent application prospects in the fields of electrochemical energy storage, electro-catalytic water and environmental remediation, and particularly, the comprehensive performance of the material is remarkably improved due to the high specific surface area, abundant active sites and a stable structure.

The invention relates to the field of biomedical materials, and particularly provides a preparation method of bioactive hydrogel for clinically retaining and slowly releasing medicine liniment.The preparation method comprises the following steps that S1, aminophenylboronic acid is dissolved in water to prepare an aminophenylboronic acid aqueous solution, a glucan derivative is added, after heating and stirring reaction, a product is collected, washed and dried, and the hydrogel is obtained; a hydrogel precursor is obtained; s2, polyphenol substances and polysaccharide substances are added into 0.5 wt%-20 wt% of an aqueous solution of the hydrogel precursor, after stirring reaction is conducted, 0.02 wt%-8 wt% of a hydrazide aqueous solution is added into the aqueous solution, ultrasonic treatment is conducted, standing is conducted, and the bioactive hydrogel can be obtained. By optimizing the variety and dosage of the components, the hydrogel can be attached to the skin, retention of the traditional Chinese medicine liniment at the focus of the skin is helped, and the action time of the liniment medicine is prolonged to 12-24 h.

This invention relates to the field of anti-corrosion reagent technology, specifically disclosing a method for manufacturing a solid oxygen-removing, bactericidal, corrosion-inhibiting, and scale-inhibiting agent for seawater oil well pipelines. The agent comprises a three-layer core-shell structure: the core layer is composed of a copolymer hydrogel of 2-acrylamido-2-methylpropanesulfonic acid and N-vinylcaprolactam, loaded with sodium isoascorbate and a copper-L-histidine complex; the middle layer is composed of 3-aminophenylboronic acid-functionalized silica nanoparticles and catechol linked by dynamic borate ester bonds; and the shell layer is composed of a copolymer of 3,4-dihydroxyphenylalanine and 1H,1H,2H,2H-perfluorodecyl acrylate coating a corrosion-inhibiting and bactericidal complex. This invention overcomes the pH conflict between oxygen removers and corrosion inhibitors in traditional reagents through the synergistic effect of the core-shell structure and dynamic bonds, achieving integrated functions of oxygen removal, bactericidal action, corrosion inhibition, and scale inhibition. It effectively inhibits microbial corrosion, reduces the risk of scaling, extends the lifespan of seawater pipelines, and is suitable for complex marine conditions.

The application discloses a CDs / GO-PBA nanocomposite probe synthesis and a Salmonella detection method. The method comprises the following steps: hydrothermal carbonization of mannose and histidine to obtain a pseudo-glycopeptide carbon dot, and then reaction of 3-aminophenylboronic acid and graphene oxide to obtain boronated modified graphene oxide GO-PBA. CDs are loaded on the GO-PBA sheet layer by forming a borate ester bond between the hydroxyl group and the boronic acid group, and CDs / GO-PBA with quenched fluorescence is obtained. The CDs / GO-PBA is added into a Salmonella typhimurium bacterial suspension, and after the CDs bind to the Salmonella typhimurium through the lectin-sugar interaction, the dynamic borate ester bond is broken, the CDs are separated from the graphene surface, and the fluorescence is restored. The concentration of the Salmonella typhimurium is detected by measuring the fluorescence intensity through a fluorescence spectrometer. The method can quickly and quantitatively detect the Salmonella typhimurium, and has good sensitivity and a wide detection range.

The invention relates to the technical field of cell catalysts, in particular to a high-activity catalyst for a proton exchange membrane fuel cell and a preparation method of the high-activity catalyst. The preparation method comprises the following steps: firstly, carrying out pretreatment on Ti < 3 > C < 2 > T < x > MXene powder to obtain dispersion liquid; then reducing chloroplatinic acid and ferric nitrate through ascorbic acid by taking the nitrogen-doped carbon-coated platinum-iron alloy as a carrier, and carrying out high-temperature cracking in combination with dicyandiamide to generate a nitrogen-doped carbon-coated platinum-iron alloy in situ; loading iridium oxide on the surface through a hydrothermal method; and finally introducing ruthenium trichloride and phenanthroline, performing high-temperature pyrolysis to form a ruthenium-nitrogen coordination structure, and performing acid pickling, activation and 4-aminophenylboronic acid surface modification to obtain the final catalyst. Through MXene carrier optimization, multi-metal component collaboration and surface modification, the electrocatalytic activity and stability of the catalyst are remarkably improved, dependence on precious metal is reduced, and the catalyst is suitable for efficient operation of the proton exchange membrane fuel cell.

The invention discloses a preparation method of an epinephrine substance-loaded silk fibroin microneedle transdermal patch, which comprises the following steps: dissolving aminophenylboronic acid in a dimethyl sulfoxide aqueous solution to obtain an aminophenylboronic acid solution; adding the aminophenylboronic acid solution into a silk fibroin aqueous solution, then adding 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride and N-hydroxysuccinimide, and uniformly mixing to obtain a reaction solution; after the reaction of the reaction solution is finished, dialyzing to remove the small molecule catalyst and dimethyl sulfoxide to obtain a first mixed solution; the method comprises the following steps: dissolving an epinephrine substance in deionized water to obtain an epinephrine substance solution; adding the epinephrine substance solution into the first mixed solution, and uniformly mixing to obtain a second mixed solution; and casting the second mixed solution into a microneedle mold, defoaming, and drying to obtain the adrenaline substance-loaded silk fibroin microneedle transdermal patch.

This invention discloses a method for preparing a bilayer hydrogel microneedle patch loaded with nanomaterials, comprising: providing carbon nanotube particles loaded with calcium peroxide; grafting ferric tannate; grafting dihydroporphyrin E6 to obtain carbon nanotube particles loaded with calcium peroxide and grafted with dihydroporphyrin E6 and ferric tannate; dispersing the carbon nanotube particles loaded with calcium peroxide and grafted with dihydroporphyrin E6 and ferric tannate in a mixed solution composed of polyvinyl alcohol and polyvinylpyrrolidone to obtain a microneedle patch tip; providing sodium hyaluronate grafted with 3-aminophenylboronic acid; stirring the sodium hyaluronate grafted with 3-aminophenylboronic acid and polyvinyl alcohol solution on the microneedle patch tip to form a gel, thereby obtaining a bilayer hydrogel microneedle patch loaded with nanomaterials. This bilayer hydrogel microneedle patch loaded with nanomaterials can effectively achieve anti-tumor effects by directly delivering nanomaterials to the tumor site, promoting self-oxygenation within the tumor, and promoting tumor ablation.

This invention relates to the field of lithium battery technology, and more particularly to a preparation process for a lithium battery additive. The process first prepares a Zn-MOF-74 catalyst through dissolution, crystallization, separation, and stepwise vacuum drying. Then, using γ-valerolactone as a solvent, propenyl-1,3-sulfonyl lactone undergoes an addition reaction with 4-aminophenylboronic acid under the action of the catalyst to generate an intermediate. This intermediate then undergoes a substitution reaction with ethyl bromoethyl, followed by recrystallization and vacuum drying to obtain a sulfonate-boron-oxygen heterocyclic synergistic additive. This additive utilizes the synergistic effect of the sulfonate group and the boron-oxygen heterocycle to improve the ionic conductivity of the electrolyte and inhibit its decomposition, significantly improving the room-temperature cycle life, wide-temperature-range discharge performance, and high-temperature storage stability of lithium batteries. The preparation process is controllable, the product has high purity, and it is suitable for various high-performance lithium batteries.

This invention belongs to the field of lubricating oil additives, specifically relating to a soot-dispersible polyisobutylene succinimide dispersant, its preparation method, and its application. The preparation method includes the following steps: (1) mixing polyisobutylene maleic anhydride, base oil, and aromatic solvent, stirring evenly, heating, adding polyethylene polyamine, introducing nitrogen gas, heating to the aromatic reflux temperature, and performing an amidation reaction to obtain product 1; (2) adding aminophenylboronic acid to product 1, continuing reflux, borizing reaction, removing the solvent by vacuum distillation, filtering, and obtaining the soot-dispersible polyisobutylene succinimide dispersant. The dispersant in this invention has the characteristic of good soot dispersion performance. The prepared product can improve the soot dispersion of oil products with a lower dosage. Moreover, the use of aminophenylboronic acid for borization reaction can improve high-temperature detergency. The preparation process of this invention is simple and easy to implement.

This invention discloses a vascular occlusive gel composition, comprising a first component and a second component. The first component comprises cysteine-modified carboxymethyl cellulose and dopamine-modified carboxymethyl cellulose. The second component comprises 3-aminophenylboronic acid-modified carboxymethyl cellulose and hydroxyethyl methacrylate-modified carboxymethyl cellulose. This invention also discloses a vascular occlusive gel prepared from the above composition and its preparation method. This invention employs a two-component system that can rapidly crosslink to form a sealing hydrogel with excellent tissue adhesion, mechanical properties, and biocompatibility, effectively achieving physical occlusion of diseased blood vessels. Furthermore, all components exhibit good biocompatibility and biodegradability, ensuring medical safety.

The invention discloses injectable piezoelectric hydrogel for treating osteoarthritis as well as a preparation method and application of the injectable piezoelectric hydrogel. The injectable piezoelectric hydrogel is prepared from an oxidized chondroitin sulfate-3-aminophenylboronic acid polymer hydrogel matrix and piezoelectric nano particles dispersed in the polymer hydrogel matrix, the piezoelectric nano-particle comprises a core layer and a cartilage cell membrane layer, wherein the core layer is composed of biocompatible piezoelectric nano-particles, and the core layer is coated with the cartilage cell membrane layer. The surface of the cartilage cell membrane layer is conjugated with cartilage targeting peptide. The injectable piezoelectric hydrogel material provided by the invention has strong oxidation resistance, and meanwhile, piezoelectric-induced mitochondrial autophagy can reduce the generation of reactive oxygen species from the source, so as to synergistically protect cartilage cells.

The invention relates to the technical field of molecular fluorescence, in particular to a polarity-sensitive fluorescent probe based on ICT and a preparation method and application of the polarity-sensitive fluorescent probe. The preparation method of the polarity sensitive type fluorescent probe comprises the following steps: enabling 4, 7-dibromobenzo [c]-1, 2, 5-thiadiazole to react with [4-[bis (4-methoxyphenyl) amino] phenyl] boric acid to obtain 4-(7-bromo-2, 1, 3-benzothiadiazole-4-yl)-N, N-bis (4-methoxyphenyl) benzylamine, and enabling the 4, 7-dibromobenzo [c]-1, 2, 5-thiadiazole to react with [4-[bis (4-methoxyphenyl) amino] phenyl] boric acid to obtain 4-(7-bromo-2, 1, 3-benzothiadiazole-4-yl)-N, N-bis (4-methoxyphenyl) benzylamine. The preparation method comprises the following steps: enabling 4-(7-bromo-2, 1, 3-benzothiadiazole-4-yl)-N, N-bis (4-methoxyphenyl) benzylamine and (6-nitropyridine-3-yl) boric acid to react, so as to prepare the polarity sensitive type fluorescent probe. The polarity-sensitive fluorescent probe can be used as an effective tool for detecting the polarity change of the lipid droplet, and provides auxiliary diagnosis for diagnosis of some diseases related to the lipid droplet by dynamically monitoring the continuous process of the lipid droplet from generation to maturation to decomposition.

The invention discloses a fluoride-free environment-friendly high-cooling insulating fire extinguishing agent and a preparation method thereof, and belongs to the technical field of fire extinguishing agents. The fire extinguishing agent comprises an agent A and an agent B. The agent A comprises, by mass, 30-50 parts of a nonionic surfactant, 10-20 parts of a cosolvent, 5-15 parts of 3-aminophenylboronic acid modified cyclodextrin and 80-100 parts of deionized water. The agent B is prepared from the following raw materials in parts by mass: 0.6 to 1.2 parts of sodium bicarbonate, 2.5 to 3.5 parts of polyvinyl alcohol, 1.0 to 1.8 parts of tannic acid modified dopamine, 0.3 to 0.7 part of ammonium persulfate, 0.5 to 1.0 part of a cross-linking agent, 0.2 to 0.8 part of an insulating nano material and 200 to 300 parts of deionized water. The fluorine-free, high-cooling, insulating and anti-after-combustion comprehensive fire extinguishing agent adopts the A and B double-component form, is good in stability, and realizes the fluorine-free, high-cooling, insulating and anti-after-combustion comprehensive fire extinguishing effect through the combined action of multiple mechanisms.

This invention belongs to the field of nanoparticle hydrogel scaffold technology, providing an MMP-responsive nanoparticle hydrogel scaffold and its application in the treatment of fibrous bone dysplasia. The nanoparticle hydrogel scaffold is prepared by cross-linking and curing triglyceride monostearate nanoparticles, 3-aminophenylboronic acid-modified hyaluronic acid, and dopamine-modified hyaluronic acid. This invention is based on the first discovery that the concentration of matrix metalloproteinases (MMPs) around fibrous bone dysplasia lesions is a biomarker reflecting the "activity and treatment response of fibrous bone dysplasia lesions," and based on this discovery, provides an MMP-responsive nanoparticle hydrogel scaffold and its application in the treatment of fibrous bone dysplasia. This nanoparticle hydrogel scaffold can achieve perilesional drug delivery and sustained MMP-responsive drug release through injection, thereby providing a local treatment strategy for fibrous bone dysplasia.

The invention relates to a hydrogel adhesive for repairing acute and chronic infected wounds and inhibiting scars as well as a preparation method and application of the hydrogel adhesive. Specifically, the invention provides a hydrogel adhesive which comprises a) 3-aminophenylboronic acid modified hyaluronic acid (HA-PBA) and b) a short-chain molecule M containing more than two amino groups. The hydrogel adhesive has good biological properties of wound adhesion, sterilization, scar hyperplasia inhibition and the like, and can be used as a hydrogel adhesive for repairing acute and chronic infected wounds.

The invention discloses a three-dimensional senescence cell model and a construction method and application thereof, and relates to the technical field of cell model construction.The method comprises the steps that after cells are subjected to two-dimensional culture, a cell suspension is prepared; the preparation method comprises the following steps: mixing methacryloyl gelatin, human I-type collagen, a photoinitiator and a synthetic high-molecular polymer in a PBS (Phosphate Buffer Solution) to prepare bio-ink; the synthetic high-molecular polymer is obtained by mixing 3-aminophenylboronic acid grafted sodium alginate and methylacryloylated sodium alginate; mixing the obtained bio-ink with a cell suspension, and performing three-dimensional printing to obtain a cell model; and performing oxidative stress condition treatment, cleaning and culture on the obtained cell model to obtain the three-dimensional senescence cell model. According to the invention, a three-dimensional biological printing technology mode is adopted, and an aging cell model with a three-dimensional structure is constructed. The three-dimensional fibroblast aging model established by the invention is real and reliable, and supports are provided for subsequent in-depth research on aging mechanisms, screening of anti-aging drugs, research and development of new drugs and the like.

The invention discloses a synthesis method of cabozantinib, which comprises the following steps: reacting methoxyquinoline, 4-aminophenylboronic acid pinacol ester, boric acid B (OH) 3, a catalyst copper salt and a molecular sieve in a solvent to prepare 6, 7-dimethoxy-4-(4-aminophenoxy) quinoline, dissolving the 6, 7-dimethoxy-4-(4-aminophenoxy) quinoline in a tetrafluoroboric acid aqueous solution, and carrying out a reaction to obtain the cabozantinib. The preparation method comprises the following steps: adding a sodium nitrite aqueous solution under an ice-water bath condition to react to prepare a compound 4, putting the compound 4, 1, 1-dicyanocyclopropane and potassium phosphate into a mixed solvent of water and ethyl acetate, and reacting at 60-90 DEG C under the protection of oxygen-free gas to prepare a compound 5; and putting the compound 5, p-fluorobenzene diazonium tetrafluoroborate and potassium phosphate into a mixed solvent of ethyl acetate and water, and reacting at 60-90 DEG C under the protection of oxygen-free gas to prepare the target product cabozantinib. The method is mild in reaction condition, simple and convenient to operate, high in product yield, high in purity, low in production cost and suitable for industrial production of cabozantinib.

This invention discloses a quinolinonylpropane sulfonate, its preparation method, and its application. The structural formula of the quinolinonylpropane sulfonate is shown in formula (III). The preparation method is as follows: using 4-methylquinoline and 1,3-propanesulfonic acid lactone as raw materials, a reaction is carried out to obtain product (I); using (4-(diphenylamino)phenyl)boronic acid and 7-bromobenzo[c][1,2,5]thiadiazole-4-carboxaldehyde as raw materials, a coupling reaction is carried out under potassium carbonate and nitrogen atmosphere catalyzed by tetrakis(triphenylphosphine)palladium to obtain product (II); using products (I) and (II) as raw materials, quinolinonylpropane sulfonate (III) is prepared. The quinolinonylpropane sulfonate of this invention exhibits antibacterial activity, especially against Streptococcus pneumoniae, and can be used as an antibacterial agent.

The invention provides an acrolein fluorescent probe based on a coumarin derivative, a preparation method of the acrolein fluorescent probe and application of the acrolein fluorescent probe in biological detection, and belongs to the field of small organic molecule fluorescent probes. The preparation method of the acrolein fluorescent probe based on the coumarin derivative comprises the following steps: in a solvent environment, carrying out contact reaction on 7-diethylamino coumarin and N-bromosuccinimide to obtain a compound 3; and contacting the compound 3 with 4-aminophenylboronic acid, carrying out a heating reaction, and purifying to prepare the acrolein fluorescent probe based on the coumarin derivative. The acrolein fluorescent probe based on the coumarin derivative is easy and convenient to operate, good in acrolein recognition selectivity, high in response speed, high in sensitivity, good in fluorescence stability and anti-interference performance and capable of rapidly and accurately detecting acrolein in the real-time acrolein detection process; meanwhile, the preparation process of the fluorescent probe is simple, the preparation efficiency is high, and the preparation cost is low.

The invention belongs to the technical field of biomedical materials, and relates to I-type and II-type naphthalimide photosensitizers and a preparation method and application thereof, and the naphthalimide photosensitizers have the following structural formula. The preparation method comprises the following steps: S1, carrying out a heating reaction on 4-bromo-1, 8-naphthalic anhydride and n-butylamine to obtain NI-1; s2, NI-1 and [4-[bis (4-methoxyphenyl) amino] phenyl] boric acid are subjected to a reaction under the action of an XPhos Pd G2 catalyst and a K3PO4 alkali, and NI-OCH3-2O is obtained; and S3, the NI-OCH3-2O and a Lawson reagent are subjected to a heating reaction, and XX is obtained. Compared with the prior art, the preparation method has the advantages that naphthalimide is used as a mother nucleus, a photosensitizer precursor NI-OCH3-2O is obtained through Suzuki coupling reaction and [4-[bis (4-methoxyphenyl) amino] phenyl] boric acid, and finally the photosensitizer NI-OCH3-2S is obtained through carbonyl thiolation. The naphthalimide photosensitizer has relatively strong absorption in a range of 400-700 nm, generates O2 <-> and < 1 > O2 under excitation of red light, can overcome limitation of tumor hypoxia, and has a good photodynamic therapy effect.

This invention belongs to the field of heterocyclic compound technology, specifically relating to a pyrene derivative and its preparation method and application. The preparation method of the pyrene derivative includes the following steps: (1) adding 10-(6-bromopyrene-1-yl)-10H-phenthiazide, tetra(triphenylphosphine)palladium and potassium carbonate aqueous solution to an organic solution containing 4-(diphenylamino)phenylboronic acid and stirring to carry out a condensation reaction to obtain a pyrene derivative solution; (2) diluting the pyrene derivative solution and washing it, separating the phases to obtain an organic phase and an aqueous phase, extracting the organic phase from the aqueous phase, combining the organic phases and drying them to obtain an organic phase containing the pyrene derivative; (3) pre-distilling, chromatography and rotary evaporation of the organic phase containing the pyrene derivative to obtain the pyrene derivative. This invention changes the electron cloud arrangement in the pyrene derivative by introducing different groups into the asymmetric structure of the pyrene derivative, thereby changing the fluorescence properties, which has important applications in fingerprint fluorescence imaging.

This invention relates to the field of lithium-ion battery technology, specifically to a method for preparing a multifunctional self-healing silicon-based material binder, comprising the following steps: 1. Synthesizing and preparing 1-allyl-1-methylpyrrolidone-onium bis(fluorosulfonamide)imine ionic liquid; 2. Crosslinking reaction to generate 1-allyl-1-methylpyrrolidone-onium bis(trifluoromethanesulfonyl)imine polyionic liquid; 3. Preparing (aniline-copoly-3-aminophenylboronic acid) / fluorinated polyionic liquid powder, dissolving the powder in N-methylpyrrolidone solvent to obtain a self-healing silicon-based material binder liquid composite. The binder prepared by this method can simultaneously and efficiently solve the problems of conductive network destruction, particle pulverization, repeated SEI film growth, and interface impedance rise faced by silicon-based anodes during cycling, effectively improving the energy density, cycle life, and rate performance of the battery.

The application relates to the field of corrosion prevention technology, and particularly relates to a preparation process of heavy-duty anticorrosive paint for building bridges, which introduces a self-repairing prepolymer into water-based epoxy resin as a base material to improve the durability, uses composite basalt flakes as fillers, introduces diluents and penetrants as assistants under the action of a water-based amine curing agent, grows nanometer silicon dioxide on the surface of the basalt flakes in situ to obtain pretreated basalt flakes, and then grafts 2-urea-based-4[1H] pyrimidone; the self-repairing prepolymer is a silicone-modified prepolymer grafted with composite phenylboronic acid ester; the composite phenylboronic acid ester is obtained by a thiol-ene click reaction of eugenol and 3-mercapto-1,2-propanediol to obtain double-hydroxyl eugenol, and then grafted with 2-urea-based-4[1H] pyrimidone under the action of boron-nitrogen coordination between 2-dimethylaminoethylamine and 3-aminophenylboronic acid to form phenylboronic acid ester with pH response by dehydration.

The application relates to the field of pouring sealant, and discloses a modified epoxy resin pouring sealant and a preparation method thereof. The pouring sealant comprises an epoxy resin, modified inorganic fillers, modified additives and an auxiliary agent. The modified inorganic fillers are prepared by grafting quaternary ammonium s-triazine derivatives onto inorganic fillers. The quaternary ammonium s-triazine derivatives are prepared by sequentially substituting 3,5-diaminophenyl boronic acid, cyanuric chloride and 3-chloropropyl trimethoxysilane with 1,4-butanediamine, and then reacting with N,N-dimethyl-1,3-diaminopropane and quaternized by bromoethane. The modified additives are prepared by using modified bismaleimide monomers prepared from maleic anhydride and 5(6)-amino-1-(4-aminophenyl)-1,3,3-trimethylindane and 1-methyl-4-isopropyl cyclohexene by self-stabilizing precipitation polymerization. The pouring sealant prepared by the application has high tensile strength, good impact resistance, good heat resistance, good flame retardance, good dielectricity and good bacteriostasis.