117 results about "Aminophenylboronic acid" patented technology

The invention discloses a sunlight response high-strength self-repairing polyurethane material and a preparation method thereof, and belongs to the technical field of self-repairing materials, the sunlight response high-strength self-repairing polyurethane material is obtained by coordinating polyurethane containing an azothiazole structure and metal ions according to a certain proportion, the polyurethane containing the azothiazole structure is prepared by stirring diisocyanate, diol containing the azothiazole structure, long-chain diol and aminophenylboronic acid according to a certain proportion in N, N-dimethylformamide at room temperature to react for 5 hours. According to the invention, a photoactive azothiazole structure is introduced into polyurethane, and reversible metal coordination bonds are formed by the azothiazole structure and metal ions, so that rapid sunlight response self-repairing of the polyurethane material is realized. The self-repairing efficiency of the prepared photoresponse self-repairing polyurethane material is 95.1% after the photoresponse self-repairing polyurethane material is irradiated by sunlight for 2 h, and the photoresponse self-repairing polyurethane material has rapid photoresponse self-repairing performance and has wide application prospects in the fields of self-repairing coatings, intelligent coatings and anti-corrosion coatings.

The invention relates to the field of heat shrinkage films, in particular to an antistatic PETG heat shrinkage film. The PETG heat shrink film comprises the following components in parts by weight: 100 parts of PETG resin, 2-6 parts of an anti-adhesion agent, 2-5 parts of a lubricant, 1-5 parts of an antistatic modifier, 1-2 parts of an antioxidant and 0.5-1 part of a light stabilizer. In the preparation process of the PETG heat shrink film, a novel borate antistatic agent is introduced, and the antistatic agent is synthesized by taking tris (2-carboxyethyl) isocyanurate and 4-aminophenylboronic acid pinacol ester as raw materials, so that compared with a traditional antistatic agent, the antistatic property is better, the heat stability is obviously improved, and the service life of the heat shrink film is prolonged. And the phenomenon of local deformation or poor arc-shaped shrinkage of the PETG heat shrinkage film when the PETG heat shrinkage film shrinks at a non-uniform interface is reduced.

The invention discloses a vegetable oil-based room-temperature water-induced self-healing polyurethane elastomer and a preparation method thereof. The elastomer is prepared by taking polytetramethylene ether glycol and tung oil glycol as soft segments, isophorone diisocyanate as a hard segment, dimethylolpropionic acid as a hydrophilic chain extender and 3-aminophenylboronic acid as an end-capping reagent. Polytetramethylene ether glycol and tung oil glycol are used as soft segments, isophorone diisocyanate is used as a hard segment, dimethylolpropionic acid is used as a hydrophilic chain extender, 3-aminophenylboronic acid is used for blocking, then triethylamine is used for neutralization, and a waterborne polyurethane material with high-density crosslinking sites is synthesized. The material has good mechanical properties and fracture toughness, the tensile strength of the polyurethane film can reach 6.94 MPa, the elongation at break can reach 790.1%, and the film has good rebound resilience.

The invention discloses a double-response collagen-based conductive hydrogel, a medicine and a preparation and application method of the double-response collagen-based conductive hydrogel. The preparation method of the double-response collagen-based conductive hydrogel comprises the following steps: carrying out chemical modification on polysaccharide through 3-aminophenylboronic acid, and then carrying out sodium periodate oxidation treatment to obtain a dialdehyde polysaccharide grafted aminophenylboronic acid copolymer; the preparation method comprises the following steps: performing hydrazide modification on collagen through adipic acid dihydrazide, and performing free radical polymerization with aniline to obtain a hydrazide collagen grafted polyaniline copolymer; the dialdehyde polysaccharide grafted aminophenylboronic acid copolymer and the hydrazide collagen grafted polyaniline copolymer are subjected to crosslinking, and the double-response collagen-based conductive hydrogel capable of responding to glucose and the pH value is obtained. Compared with single-response conductive hydrogel, the hydrogel can specifically respond to the microenvironment of chronic diabetic wound surfaces and release antibacterial and anti-inflammatory drugs, and high-quality healing of chronic wounds such as diabetic foot ulcers and the like is promoted.

The invention belongs to the field of biomedical materials, and discloses a composite hydrogel dressing and application. The composite hydrogel dressing is prepared by the following steps: blending 4-aminophenylboronic acid grafted hyaluronic acid and gallic acid grafted collagen, adjusting the pH value, carrying out a cross-linking reaction to obtain a cross-linking product, and stirring and mixing the cross-linking product with a gallic acid reduced silver nanoparticle solution. The antibacterial and self-healing composite hydrogel dressing for promoting wound repair has proper adhesion, mechanical properties and free radical scavenging ability, and excellent antibacterial property, biocompatibility and self-healing ability.

The invention relates to the technical field of corrosion inhibitors, and discloses a preparation method of a modified imidazoline corrosion inhibitor, which comprises the following steps: carrying out quaternization reaction on tertiary amine group in an imidazoline intermediate and chlorine in benzyl chloride to generate quaternary ammonium salt, introducing hydroxyl, and continuing to carry out esterification reaction with boric acid group in 4-aminophenylboronic acid to obtain the modified imidazoline corrosion inhibitor. The modified imidazoline corrosion inhibitor is prepared by the following steps of: firstly, introducing amino groups, then carrying out amidation reaction with acyl chloride groups in 4-vinyl benzoyl chloride, introducing alkenyl groups, and finally carrying out click reaction with sulfydryl groups in DSB-TA, so as to generate the modified imidazoline corrosion inhibitor. The modified imidazoline corrosion inhibitor disclosed by the invention has a relatively good corrosion inhibition effect.

The invention belongs to the technical field of preparation and application of nano materials, and relates to a preparation method and application of amino-functionalized cerium oxide nano enzyme, and the preparation method comprises the following steps: adding 3-aminophenylboronic acid into a cerous nitrate hexahydrate aqueous solution to obtain a mixed solution; dropwise adding a sodium hydroxide aqueous solution into the mixed solution, carrying out hydrothermal reaction, cooling after the reaction is finished, centrifuging, washing and drying to obtain milk white powder, namely the amino-functionalized cerium oxide nano-enzyme. The boron element is introduced in the preparation of the cerium oxide nano-enzyme, and the amino-functionalized cerium oxide nano-enzyme is prepared by adopting a simple one-step hydrothermal synthesis method, so that the nano-enzyme has good phosphatase-like activity, has high selectivity and sensitivity to LPS, and is short in detection time, high in sensitivity, low in detection limit, simple in preparation process and high in preparation efficiency; the product is good in quality, high in stability, environment-friendly and extremely wide in market prospect.

The invention relates to the field of pouring sealants, and discloses a modified epoxy resin pouring sealant and a preparation method thereof, the pouring sealant comprises epoxy resin, a modified inorganic filler, a modified additive and an auxiliary agent; the modified inorganic filler is prepared by grafting a quaternized s-triazine derivative and an inorganic filler; the quaternized s-triazine derivative is prepared through the steps that 3, 5-diaminophenylboronic acid, cyanuric chloride, 3-chloropropyltrimethoxysilane and 1, 4-butanediamine are sequentially subjected to substitution to prepare a s-triazine derivative, then the s-triazine derivative reacts with N, N-dimethyl-1, 3-diaminopropane, and bromoethane is used for quaternization treatment. The modified additive is prepared from a modified bismaleimide monomer prepared from maleic anhydride and 5 (6)-amino-1-(4-aminophenyl)-1, 3, 3-trimethylindane and 1-methyl-4-isopropyl cyclohexene through a self-stabilization precipitation polymerization method, the prepared pouring sealant is high in tensile strength, good in impact resistance and good in mechanical property, and the prepared pouring sealant has the advantages of being good in mechanical property, good in mechanical property and good in mechanical property. Meanwhile, good heat resistance, flame retardance, dielectricity and antibacterial activity are achieved.

The invention discloses fluorine-containing bio-based epoxy resin as well as a preparation method and application thereof, and relates to the technical field of high polymer materials. The preparation method of the fluorine-containing bio-based epoxy resin comprises the following steps: enabling octafluoropentyloxy glycidyl ether as a fluorine unit to react with dihydric alcohol to obtain fluorine-terminated side chain butanediol, enabling the fluorine-terminated side chain butanediol to react with isocyanate to obtain a polyurethane prepolymer, and performing boric acid end capping on the polyurethane prepolymer by using 3-aminophenylboronic acid to obtain the fluorine-containing bio-based epoxy resin. The fluorine-containing bio-based epoxy resin (FBPU-ER) is prepared by the following steps: adding fluorine-containing polyurethane resin and phenylboronic acid into epoxidized soybean oil to obtain phenylboronic acid modified fluorine-containing polyurethane resin (FBPU), carrying out boric acid treatment on the epoxidized soybean oil by using 3-aminophenylboronic acid to obtain phenylboronic acid modified epoxy resin (BER), and finally, mixing the phenylboronic acid modified fluorine-containing polyurethane resin and the phenylboronic acid modified epoxy resin to obtain the fluorine-containing bio-based epoxy resin (FBPU-ER). The fluorine-containing bio-based epoxy resin prepared through fluorine-containing modification and toughening design has good mechanical properties, stability and self-repairing performance.

The invention discloses an H-aggregation type I photosensitizer as well as a preparation method and application thereof. The structural formula of the H-aggregation type I photosensitizer disclosed by the invention is # imgabs0. The H-aggregation type I photosensitizer disclosed by the invention is characterized in that aminophenylboronic acid and 5-bromothieno [3, 2-b] thiophene-2-formaldehyde are subjected to a reaction to obtain an intermediate product NBSCHO, and the NBSCHO and 3-(dicyanomethylene) indanone IC are subjected to a reaction to obtain the H-aggregation type I photosensitizer. The photosensitizer disclosed by the invention has a D-pi-A type molecular structure, and due to a well-designed plane characteristic between a pi structure and an A structure, the photosensitizer has relatively strong pi-pi accumulation capacity, and formation of H-aggregation accumulation of the photosensitizer is driven, so that the active oxygen generation effect of molecules, especially generation of I type active oxygen, is improved. The material can efficiently generate I-type active oxygen under the irradiation of white light or near-infrared laser, so that tumor cells are efficiently killed, and an efficient photodynamic therapy effect is shown.

An N-heterocycle-containing boric acid compound and a preparation method and application thereof are provided. The preparation method adopts 3-bromo-1-p-tosyl-1H-pyrrolo[2, 3-b]pyrimidine as a raw material to generate (3-((5-chloro-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)boric acid by three steps of reaction. The (3-((5-chloro-4 (1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)boric acid has good inhibition effect on the proliferation activity of brain glioma, which is proven by cell experiments.

The invention discloses ROS (reactive oxygen species) responsive hydrogel loaded with hypoxia-induced exosome as well as a preparation method and application of the ROS responsive hydrogel. The ROS responsive hydrogel comprises an ROS responsive hydrogel matrix and a hypoxia-induced exosome dispersed in the ROS responsive hydrogel matrix, and the ROS responsive hydrogel matrix is prepared by uniformly mixing hyaluronic acid grafted with 3-aminophenylboronic acid and epsilon-polylysine grafted with caffeic acid. Under a high ROS environment, boric acid ester bonds in the hydrogel can be destroyed to release exosomes and caffeic acid, and the exosomes induced by hypoxia contain more factors for promoting tissue repair and regeneration and also have the competitive advantage of high uptake rate. The ROS responsive hydrogel loaded with the hypoxia-induced exosome can realize on-demand release of the exosome, delivers the exosome with endogenous competitive advantages to an ischemic infarction region and removes excessive active oxygen to play a role in efficiently repairing myocardial infarction.

This invention discloses a hyaluronic acid-phenylboronic acid-methotrexate antitumor conjugate and its preparation method in the field of drug preparation technology. First, hyaluronic acid is activated with carboxylic acid, then subjected to an amidation reaction with 3-aminophenylboronic acid to obtain a hyaluronic acid-phenylboronic acid conjugate. Next, methotrexate is activated and added to the hyaluronic acid-phenylboronic acid mixture, followed by stirring to obtain the hyaluronic acid-phenylboronic acid-methotrexate antitumor conjugate. The preparation method of this invention is simple. While the three drugs exert their respective effects, the introduction of phenylboronic acid enhances the targeted antitumor effect of the drug. The combined use of hyaluronic acid and phenylboronic acid further reduces the toxic side effects of methotrexate and improves the biocompatibility, bioavailability, and degradability of the resulting drug, making it suitable for application in the preparation of antitumor drugs.

The invention belongs to the technical field of biomedical materials and biomedical engineering, and discloses peach gum-based self-repairing moisturizing hydrogel, a preparation method and application of the peach gum-based self-repairing moisturizing hydrogel in hemostasis and moisturizing materials. The preparation method comprises the following steps: carrying out an amide reaction on 3-aminophenylboronic acid hydrochloride (3APBA), and grafting the 3-aminophenylboronic acid hydrochloride (3APBA) on purified peach gum to obtain boronic acid peach gum (PR-3APBA); and adding an efficient humectant sodium pyrrolidone carboxylate, and freeze-drying to obtain the self-repairing hemostatic moisturizing gel. The adhesive has excellent hemostasis, moisturizing and self-repairing functions, is applied to body surface skin wound repair, and particularly has better wound repair performance and tissue adhesion performance when being used as an adhesion hemostasis material.

The invention discloses a protamine derivative and application thereof, the protamine derivative is obtained by modifying phenylboronic acid on a protamine side chain amino group, and the phenylboronic acid is selected from 4-carboxyphenylboronic acid, 2-aminophenylboronic acid, 3-carboxyl-4-fluorophenylboronic acid or 4-formyl chlorophenylboronic acid; the protamine derivative can be combined with a nucleic acid drug through a boric acid group and is used as a delivery carrier for preparing a nucleic acid drug delivery system. The invention provides a preparation scheme of phenylboronic acid modified protamine, the phenylboronic acid modified protamine is applied to nucleic acid drug delivery, after phenylboronic acid is modified, a boric acid ester bond is formed between a carrier and nucleic acid, and the nucleic acid drug can be responsively released in a high-concentration ATP environment. The functional modified protamine obviously improves the stability of a nucleic acid delivery system, enables the release of a nucleic acid drug to be controllable, and enhances the curative effect of gene therapy.

The invention discloses a trithiophene type fluorescent probe for detecting total polar substances of edible oil as well as a preparation method and application of the trithiophene type fluorescent probe. The preparation method comprises the following steps: directly carrying out a coupling reaction on 4-bis (4-methoxyphenyl) amino] phenyl]-[2, 2 ': 5', 2 ''-trithiophene-5-formaldehyde and 4-bis (4-methoxyphenyl) aminophenylboronic acid to prepare 5''-[4-[bis (4-methoxyphenyl) amino] phenyl]-[2, 2 ': 5', 2 ''-trithiophene-5-formaldehyde, and reacting the compound with 4-methylquinoline to synthesize the probe (E)-4-methoxy-N-(4-methoxyphenyl)-N-[4-(5''-(2-(quinoline-4-yl) vinyl)-[2, 2 ': 5', 2 ''-trithiophene-5-formaldehyde. The compound can selectively detect the polarity of edible oil, yellow fluorescence is quenched after the polarity of the edible oil is increased, and the compound can be used as a fluorescent probe for detecting the polarity of the edible oil.

This invention provides the application of glucose-responsive nanohydrogels in the preparation of drugs for treating skin injuries. The method includes the following steps: mixing hyaluronic acid with a phenylboronic acid compound, adding 3-aminophenylboronic acid, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride and N-hydroxysuccinimide, and performing a grafting reaction to obtain boric acid-modified hyaluronic acid; adding myricetin-3-O-galactoside, phospholipids, and cholesterol to an organic solvent, followed by thin-film hydration and ultrasonic treatment to obtain nanoliposomes; mixing the boric acid-modified hyaluronic acid with a polyvinyl alcohol solution, then adding the nanoliposome solution, and finally mixing to obtain the resulting nanohydrogel. The glucose-responsive nanohydrogel of this invention achieves adaptive drug release in the high glucose environment of diabetic wounds and regulates local metabolic homeostasis of the wound, especially the lysine degradation pathway in amino acid metabolism.

The invention discloses a preparation method of novel injectable antibacterial hydrogel based on MXene nanosheets, and the method comprises the following steps: loading magnesium ions on titanium carbide MXene nanosheets to form MXene coated Mg < 2 + > nanoparticles, grafting 3-aminophenylboronic acid to oxidized hyaluronic acid OHA to obtain modified oxidized hyaluronic acid POA, and adding the modified oxidized hyaluronic acid POA into the MXene coated Mg < 2 + > nanoparticles to obtain the injectable antibacterial hydrogel based on the MXene nanosheets. And doping the MXene coated Mg < 2 + > into the modified oxidized hyaluronic acid system, and mixing the MXene coated Mg < 2 + > with a polyvinyl alcohol (PVA) solution for reaction to prepare the PVA / POA-MXene coated Mg < 2 + > hydrogel. The hydrogel has injectable, conductive, antibacterial, anti-inflammatory and angiogenesis promoting characteristics, and can comprehensively and efficiently treat bacterial wound infection.

The invention discloses mucoprotein hydrogel loaded with cerium-dihydromyricetin nano-enzyme as well as a preparation method and application of the mucoprotein hydrogel, and relates to the technical field of biological medicines. The preparation method comprises the following steps: carrying out coordination reaction on dihydromyricetin and Ce < 4 + > to obtain cerium-dihydromyricetin nano-enzyme; the preparation method comprises the following steps: coupling hyaluronic acid with dopamine to obtain hyaluronic acid-dopamine; the preparation method comprises the following steps: coupling mucoprotein with aminophenylboronic acid to obtain mucoprotein-aminophenylboronic acid; the preparation method comprises the following steps: mixing cerium-dihydromyricetin nano-enzyme, hyaluronic acid-dopamine and mucoprotein-aminophenylboronic acid, and reacting, so as to obtain the mucoprotein hydrogel loaded with the cerium-dihydromyricetin nano-enzyme. The mucoprotein hydrogel loaded with the cerium-dihydromyricetin nano enzyme can be used for effectively treating ulcerative colitis and has an important clinical application value.

The present invention relates to the technical field of graphitized films, and discloses a preparation method of a polyimide graphitized film. In the present invention, a diamine monomer, a dianhydride monomer, intermediate 2, and amino-functionalized multi-walled carbon nanotubes are reacted to obtain a polyimide precursor film; then high-temperature heat treatment is carried out to obtain a polyimide graphitized film. The multi-walled carbon nanotube structure in the polyimide graphitized film of the present invention is graft-modified, introducing a large number of benzene rings and amino groups. Adding it to the polyimide graphitized film improves its electrical conductivity and thermal conductivity; the bromine in intermediate 1 reacts with the boric acid group in 4-aminophenylboronic acid, improving the substitution degree of its benzene ring and amino group, and forming a larger plane with the benzene ring in the amino-functionalized multi-walled carbon nanotubes, while more effectively transferring heat; the amino groups in the amino-functionalized multi-walled carbon nanotubes and intermediate 2 constitute a large amount of nitrogen sources, doping graphene and high-temperature treatment, improving the electrical conductivity of the polyimide graphitized film.

The invention relates to the technical field of culture methods, in particular to a serum-free full-suspension culture method for cat parvovirus. A quercetin-cichorium intybus extract is prepared and added into a culture medium, the quercetin-cichorium intybus extract is prepared from the following raw materials in parts by weight: 8-12 parts of a cichorium intybus extract, 2-3 parts of 3-aminophenylboronic acid and 1-2 parts of quercetin, and the quercetin-cichorium intybus extract can improve the cell activity and enhance the cell sensitivity. Modified glucan is also prepared and added into a culture medium after virus inoculation, so that the virus infection efficiency is enhanced, and the virus yield is increased.

The invention belongs to the field of inorganic functional materials, and particularly relates to a basic nickel carbonate modified material and a preparation method thereof.The method comprises the steps that nickel nitrate hexahydrate is dissolved in deionized water, urea and cetyltrimethylammonium bromide are added, the mixture is heated and stirred mildly, and stirring is performed to obtain a basic nickel carbonate modified material; then adding a specially-made polyaminophenylboronic acid nickel complex and a cobalt-nickel phosphate ethanediamine hybrid material, performing ultrasonic dispersion to form a mixed solution, and then performing hydrothermal reaction, centrifugal washing and vacuum drying to obtain a final product. The two special modified compounds are respectively prepared through a coordination reaction regulated by ammonia water and a hybridization reaction under high-temperature and high-pressure conditions. The modified material prepared by the method has a unique microstructure and enhanced physical and chemical properties, shows excellent application prospects in the fields of electrochemical energy storage, electro-catalytic water and environmental remediation, and particularly, the comprehensive performance of the material is remarkably improved due to the high specific surface area, abundant active sites and a stable structure.

The present invention discloses a multiple non-covalent bond enhanced pH / glucose-responsive Pickering emulsion, its preparation and application, which relates to the technical field of Pickering emulsions. The preparation method of the Pickering emulsion comprises the following steps: S1: reacting 3-aminophenylboronic acid hydrochloride, sodium alginate and cyclohexyl isocyanide to obtain a phenylboronic acid-based sodium alginate derivative; S2: adding diacylated anthocyanins from purple sweet potato to soy protein isolate after hydration and degradation treatment, and mixing them to obtain soy protein isolate-diacylated anthocyanins from purple sweet potato; S3: ultrasonically mixing the phenylboronic acid-based sodium alginate derivative and soy protein isolate-diacylated anthocyanins from purple sweet potato, and then homogenizing with squalene to obtain the Pickering emulsion. The Pickering emulsion of the present invention, as a supramolecular hierarchical stimulus-responsive Pickering emulsion system for targeted delivery systems, not only provides new ideas for the delivery of biofunctional compounds, enhances the corresponding bioavailability, but also builds a bridge between colloid interface chemistry and drug delivery systems.

The present invention provides a method for preparing a hydrogel hemostatic patch with underwater adhesiveness. The preparation method of the patch includes: mixing hyaluronic acid modified with o-aminophenylboronic acid, acetylated β-cyclodextrin, acrylic acid, α-ketoglutaric acid and water to prepare an HPAA hydrogel precursor solution; adding the hydrogel precursor solution into a mold and irradiating it with ultraviolet light to obtain the product. The weight part ratio of the hyaluronic acid modified with o-aminophenylboronic acid, acetylated β-cyclodextrin, acrylic acid, α-ketoglutaric acid and water is (13-17):(9-11):(140-160):(0.5-1.5):(300-350). The purpose of the present invention is to provide a method for preparing a hydrogel hemostatic patch with underwater adhesiveness for rapid and strong underwater tissue adhesion.

The present invention relates to the technical field of medical materials, and provides a smart hydrogel, a preparation method thereof, and an application thereof. The present invention introduces dopamine on the surface of TEMPO-oxidized nanocellulose, introduces 3-aminophenylboronic acid on the surface of oxidized dextran, and combines chitosan with polyvinyl alcohol to construct a hydrogel structure with a double cross-linked network based on Schiff base bonds and borate bonds. The present invention utilizes the characteristics of Schiff base bonds and borate bonds to enhance the mechanical properties of the hydrogel system; and due to the reversibility of Schiff base bonds and borate bonds, the smart hydrogel prepared by the present invention exhibits good self-repairing properties, further increasing the service life of the hydrogel; in addition, the smart hydrogel prepared by the present invention exhibits excellent antibacterial properties due to the presence of chitosan, which helps prevent bacterial infection at the wound site, thereby promoting wound repair, and has broad application prospects in the field of wound dressings.

The invention relates to a novel method for synthesizing clarithromycin, which specifically comprises the following steps: simultaneously protecting 9-position carbonyl, 11-position hydroxyl and 12-position hydroxyl of erythromycin by using o-aminophenylboronic acid and derivatives thereof, protecting 2 '-position hydroxyl and 4'-position hydroxyl of erythromycin by using trimethylsilyl, methylating, and hydrolyzing to obtain clarithromycin. The method has the effects of short process route, cheap and easily available raw materials, high yield and low cost.

The invention discloses a preparation method of a fast-charging electrolyte for a sodium-ion battery, and relates to the technical field of sodium-ion batteries. The specific preparation method comprises the following steps: mixing the main film-forming agent, the additive, the solvent and the sodium salt, and then performing ultrasonic dissolution to obtain the electrolyte. Fluoroethylene carbonate is used as a main film-forming agent and preferentially participates in the formation of a negative electrode solid electrolyte interface film, so that the interface impedance is reduced and the continuous decomposition of the electrolyte is inhibited; additives including triphenyl phosphate, isodecyl diphenyl phosphate, trineopentyl phosphate and 4-aminophenylboronic acid pinacol ester are introduced, so that a desolvation energy barrier of Na < + > at an interface is reduced, and a more stable and effective interface film is formed; propylene carbonate and methyl ethyl carbonate are used as solvents, so that the sodium ion transmission efficiency is ensured; high-concentration sodium salt is used for promoting formation of a solvation structure for anion aggregation; and finally, the button cell prepared from the prepared electrolyte can effectively support fast charging and has good electrochemical performance.

The invention relates to the field of biomedical materials, and particularly provides a preparation method of bioactive hydrogel for clinically retaining and slowly releasing medicine liniment.The preparation method comprises the following steps that S1, aminophenylboronic acid is dissolved in water to prepare an aminophenylboronic acid aqueous solution, a glucan derivative is added, after heating and stirring reaction, a product is collected, washed and dried, and the hydrogel is obtained; a hydrogel precursor is obtained; s2, polyphenol substances and polysaccharide substances are added into 0.5 wt%-20 wt% of an aqueous solution of the hydrogel precursor, after stirring reaction is conducted, 0.02 wt%-8 wt% of a hydrazide aqueous solution is added into the aqueous solution, ultrasonic treatment is conducted, standing is conducted, and the bioactive hydrogel can be obtained. By optimizing the variety and dosage of the components, the hydrogel can be attached to the skin, retention of the traditional Chinese medicine liniment at the focus of the skin is helped, and the action time of the liniment medicine is prolonged to 12-24 h.

This invention relates to the field of anti-corrosion reagent technology, specifically disclosing a method for manufacturing a solid oxygen-removing, bactericidal, corrosion-inhibiting, and scale-inhibiting agent for seawater oil well pipelines. The agent comprises a three-layer core-shell structure: the core layer is composed of a copolymer hydrogel of 2-acrylamido-2-methylpropanesulfonic acid and N-vinylcaprolactam, loaded with sodium isoascorbate and a copper-L-histidine complex; the middle layer is composed of 3-aminophenylboronic acid-functionalized silica nanoparticles and catechol linked by dynamic borate ester bonds; and the shell layer is composed of a copolymer of 3,4-dihydroxyphenylalanine and 1H,1H,2H,2H-perfluorodecyl acrylate coating a corrosion-inhibiting and bactericidal complex. This invention overcomes the pH conflict between oxygen removers and corrosion inhibitors in traditional reagents through the synergistic effect of the core-shell structure and dynamic bonds, achieving integrated functions of oxygen removal, bactericidal action, corrosion inhibition, and scale inhibition. It effectively inhibits microbial corrosion, reduces the risk of scaling, extends the lifespan of seawater pipelines, and is suitable for complex marine conditions.

The invention relates to the technical field of biomedical materials, in particular to double-responsiveness hydrogel as well as a preparation method and application thereof. The invention provides a dual-responsiveness injectable hydrogel. The dual-responsiveness injectable hydrogel comprises oxidized hyaluronic acid (OHA) and hyaluronic acid-3-aminophenylboronic acid (HA-PBA), the OHA and the HA-PBA are connected through a Schiff base bond; hA and PBA in the HA-PBA are connected through a boric acid ester bond. The hydrogel has ROS (reactive oxygen species) and pH (potential of hydrogen) double responsiveness due to existence of borate bonds and Schiff base bonds, and is suitable for being used as a carrier of a rheumatoid arthritis drug delivery system; hyaluronic acid is a main component of synovial fluid and is beneficial to relieving pain of a patient suffering from rheumatoid arthritis; the hydrogel is simple in used raw materials and simple and convenient in preparation process, and is expected to be applied to local drug delivery of rheumatoid arthritis and other pathological microenvironment diseases with high active oxygen or low pH.