1353 results about "Supermolecule" patented technology

A composition includes at least one organic compound of a first type of the general formula I and at least one organic compound of a second type of the general structural formula II, wherein Core in formula I is a conjugated organic unit capable of forming a rigid rod-like macromolecule, Gk is a set of ionogenic side-groups providing solubility of the organic compound of the first type in a solvent and give rigidity to the rod-like macromolecule; and wherein Sys in formula II is an at least partially conjugated substantially planar polycyclic molecular system capable of forming board-like supramolecules via π-π-interaction, and X, Y, Z and Q are substituents. The composition is capable of forming a lyotropic liquid crystal solution, which can form a solid retardation layer of biaxial type substantially transparent to electromagnetic radiation in the visible spectral range. The type and degree of biaxiality of the said optical retardation layer is controlled by a molar ratio of the organic compounds of the first and the second type in the composition. An optical film comprising a solid retardation layer formed of the composition, a method of producing the optical film, and a vertical alignment liquid crystal display using said retardation layer are also provided.

The invention relates to a preparation method of a biodegradable diaphragm for promoting regeneration of periodontal tissue, belonging to the field of biological regeneration medicine. In the invention, polylactic acid, polycaprolactone, polylactic acid-glycollic acid copolymer, collagen, modified chitosan and other biodegradable synthetic polyester polymers or natural biodegradable high molecular materials are used as raw materials to prepare a thin-film material with a nano structure through the electrostatic spinning process, and then, various growth factors are loaded on the thin-film material through the supermolecule loading technology. The diaphragm for reparative regeneration of the periodontal tissue, which is prepared by the method of the invention, has good biocompatibility and can realize the purposes of inhibiting inflammation and inducing regeneration of the periodontal tissue through the controlled release of the loaded growth factors.

The invention discloses a copolymer with temperature resistance and water solubility and the preparation method and application thereof, which is characterized in that: 20 portions of acrylic amide, 0.1 to 10 portions of anion monomer or / and cation monomer, 0.05 to 3 portions of fluorine-containing styrene or / and perfluoroalkyl styrene hydrophobic monomer, 0.5 to 60 portions of surface active agent and 50 to 700 portions of deionized water are put into a three-necked reaction bulb; after the solution pH is regulated to be equal to 2.5 to 9 and N2 is connected for 30 minutes, 0.001 to 0.2 portion of an evocating agent of persulfate is added under temperature of 20 to 70 DEG C, reacting for 6 to 36 hours, and PATF is prepared. Then water is used for diluting so as to prepare PATF concentrated solution, thus obtaining a copolymer that has medium molecular weight and water solubility, is high-temperature resistant, has an ability of molecular association and can be used in high temperature and high salinity reservoir. The copolymer is prepared into aqueous solution with a mass concentration of 0.3 to 3g / L and a surface-active-agent concentration of 0.01 to 4mmol / L, which is put in a blending container with a dasher and is stirred even at room temperature to prepare a polymer oil-displacing agent which is high-temperature resistant, high tackifying and anti-sharing and has excellent aging resistance under high salinity and the temperature of 110 DEG C. The prepared oil-displacing polymer has excellent solution properties owing to the supermolecular structure formed by the association between molecules of fluorine-containing cinnamene or / and alkylbenzene hydrophobic groups, thus having favorable application prospects in high temperature and high salinity reservoir exploitation.

The invention provides supramolecular metal complexes as DNA cleaving agents. In the complexes, charge is transferred from one light absorbing metal (e.g. Ru or Os) to an electron accepting metal (e.g. Rh) via a bridging π-acceptor ligand. A bioactive metal-to-metal charge transfer state capable of cleaving DNA is thus generated. The complexes function when irradiated with low energy visible light with or without molecular oxygen.

A supramolecule has a first supramolecular component including a first effector molecule covalently joined to a first nucleic acid, and a second supramolecular component including a second effector molecule covalently joined to a second nucleic acid, wherein the second nucleic acid has a region of at least partial complementarity to the first nucleic acid, wherein the first nucleic acid is in a base pairing relationship with the second nucleic acid and the first or second effector molecules are proteins, polypeptides, lipids or sugars. The supramolecule may further have a third supramolecule component which includes a third effector molecule covalently joined to a third nucleic acid, wherein the third nucleic acid has a region of at least partial complementary to the first nucleic acid or the second nucleic acid and wherein the third nucleic acid is in a base pairing relationship with the second nucleic acid or the first nucleic acid.

The invention discloses a method for in-situ preparing antibacterial supermolecule aquogel. The method comprises the following operation steps: silver nitrate crystal and polyethyleneglycol-polypropylene glycol-polyethyleneglycol triblock copolymer solution are mixed and stirred to obtain mixed solution; the steps of stirring the mixed solution for 15 minutes and ultrasonically dispersing the mixed solution for 5 minutes are alternatively carried out for 2-4 hours to obtain nano silver sol; and the nano silver sol and Alpha-cyclodextrin solution are mixed, stirred and stands at the room temperature to obtain hydrogel. The hydrogel can be used for preparing injectable drug carriers. The invention has the advantages of simple operation, adjustable gel strength and the gelation time, room temperature forming, no involvement of chemical cross linking reaction and the usage of organic solvent, favorable biocompatibility and antibacterial property of obtained gel, and the like and is prospective to be widely applied in the field of biomedical engineering materials.

The invention relates to a pillar[5]arene / isophthalic acid-1,8-naphthalenedicarboximide complex. The complex uses copillar[5]arene as a subject, isophthalic acid-1,8-naphthalenedicarboximide as an object and C-H...PI and electrostatic force as driving force; and a part of isophthalic acid-1,8-naphthalenedicarboximide with negative charges is included into the cavity of copillar[5]arene through self-assembling in an alkaline environment, so the process of assembling of the subject and the object is finished. After aluminum ions are added into a solution of the pillar[5]arene / isophthalic acid-1,8-naphthalenedicarboximide complex, the fluorescence of the complex solution is enhanced and yellow fluorescent light is given out; and when anionic CN<-> is further added, the fluorescence of the complex solution undergoes a red shift and green fluorescent light is given out. Therefore, the pillar[5]arene / isophthalic acid-1,8-naphthalenedicarboximide complex is applicable as a novel supramolecular fluorescence sensor for continuous detection of Al<3+> and CN<-> in environment.

The invention discloses a preparation method of a double-sensitivity cyclodextrin supermolecule aggregate, belonging to the technical field of functional materials. The preparation method comprises the following steps of preparing a host molecule-photosensitive 4-hydroxycinnamic acid-cyclodextrin (4HCA-CD) by using 4-hydroxycinnamic acid (4HCA) to modify beta-cyclodextrin (beta-CD); using trithioester with adamantine (AD) at tail end as a chain transfer agent, and preparing temperature-sensitive object polymer-double-arm adamantine-poly(N-isopropyl acrylamide)-adamantine (AD-PNIPAM-AD) by using a reversible addition-fragmentation chain transfer free radical polymerization (RAFT) method; constructing a double-sensitivity supermolecule inclusion complex 4HCA-CD / AD-PNIPAM-AD by utilizing comprehensive performance of a beta-CD dewatering cavity and AD; and self-assembling the 4HCA-CD / AD-PNIPAM-AD to form the supermolecule aggregate which is capable of realizing reversible conversion in shape and size by changing light and temperature. The supermolecule aggregate prepared by the preparation method disclosed by the invention has good light / temperature double sensitivities and is capable of carrying out smart response onto external stimulus, so that the supermolecule aggregate has a wide application prospect in the fields of drug loading, controlled release, and the like.

The invention discloses a graphene / hyaluronic acid assembly taking cyclodextrin as a medium. The graphene / hyaluronic acid assembly is a nano supermolecule assembly synthesized based on beta-cyclodextrin-modified graphene and adamantine-modified hyaluronic acid, wherein graphene is modified by beta-cyclodextrin; by virtue of strong host-guest interaction between beta-cyclodextrin and adamantine, graphene and hyaluronic acid are combined together to form the supermolecule assembly. The graphene / hyaluronic acid assembly has the advantages that the supermolecule assembly greatly improves stability and biocompatibility of the cyclodextrin-modified graphene under physiological conditions; by utilizing targeted recognition action of hyaluronic acid on tumor cells, the supermolecule assembly can selectively kill the cancer cells, and has anti-cancer activity higher than that of pure drug camptothecin; the targeted drug transmission system is simple in preparation process, easy to implement and low in material cost, and has potential application prospect in clinic treatment of cancers.

The invention discloses a supramolecule assembly of targeting-delivery anticancer adamplatin. The supramolecule assembly is a binary supramolecule assembly which is synthesized on the basis of cyclodextrin-decorated hyaluronic acid and adamplatin. A preparation method of the supramolecule assembly is characterized in that the cyclodextrin-decorated hyaluronic acid and the adamplatin are respectively synthesized, and through the strong non-covalent interaction of cyclodextrin and adamantine and the amphiphilic action of molecules, a supermolecule nano particle which takes the hydrophilic hyaluronic acid as a shell and the adamplatin as a core is formed. The supramolecule assembly disclosed by the invention has the advantages that the supramolecule assembly of the targeting-delivery anticancer adamplatin has a simple synthetic route, is low in preparation cost and high in productivity, and is suitable for amplification synthesis and practical production application; and through endocytosis in which a malignant cell surface hyaluronic acid receptor serves as a medium, the supramolecule assembly (HAP) is brought in cancer cells in a target manner, so that the protection of normal cells and the targeting selective killing of cancer cells are realized, the anti-cancer activity is obviously improved, and toxic and side effects are obviously reduced.

The invention designs and synthesizes a novel supermolecular sensor P5-B1. Pillar [5] arene P5 is adopted as a subject, a pyridine functionalized naphthalene diformyl derivative B1 is adopted as an object, the subject and the object are complexed in a H2O-DMSO system, the object B1 penetrates into a molecular cavity of the object P5 so as to form the supermolecule P5-B1, the supermolecular sensor can be coordinated with Fe3+ to form a supermolecular sensor complex P5-B1Fe, and fluorescence quenching is carried out at the same time, so that supermolecular sensor can be applied in single selective fluorescent recognition of the Fe3+, and the lowest limit of detection is 5.01*10<-7>. F- is added in the sensor complex P5-B1Fe, and green fluorescence of the sensor complex is recovered, so that the F- can be efficiently selected and recognized, and the lowest limit of detection is 4.07*10<-6>. In addition, competitiveness distinguishing complex can be also used as an 'ON-OFF-ON' type fluorescence switch, and the recognition performance has important application value in the ion recognition field.

The invention discloses a dynamic polymer with a hybrid cross-linking network. The polymer comprises at least one network structure, which contains covalent cross-linking and supermolecule hydrogen bond cross-linking; at least one network comprises covalent cross-linking; and the covalently cross-linking is above the gel point of covalently cross-linked in at least one network. Due to the reversibility of dynamic hydrogen bonds, the dynamic polymers have properties of good toughness, energy dissipation, self-healing property and the like. The dynamic polymer with a hybrid cross-linking networkprovided by the invention is widely applied to the aspects of physical protection in sports and daily life and work, physical protection of military police, explosion protection, protection of airborne troops and air drops, Impact protection of automobiles, impact protection of electronic materials, and the like.

The invention belongs to the field of functional materials, and discloses a mesoporous graphite phase carbon nitride and a preparation method and application thereof. Ammonium salt is utilized as a pore-forming agent and a hydrothermal inducer and melamine is taken as a precursor, so that controllable mesoporous g-C3N4 is prepared. Ammonium salt is hydrolyzed in water, an acidic environment is provided, melamine is partially converted into cyanuric acid under the acidic condition, melamine and cyanuric acid are connected through hydrogen bonds between molecules to form supermolecules, the supermolecules are then roasted, cyanuric acid in the supermolecules is decomposed in the process of roasting to produce a great deal of gas (serving as a bubble template), meanwhile, voids are left over,so that rich pore structures are produced in the process of forming carbon nitride by the pyrocondensation polymerization of melamine, ammonium chloride which remains after hydrothermal treatment also plays the role of the bubble template, and ultimately, the mesoporous graphite phase carbon nitride with high catalytic performance is obtained.

The invention provides a chiral supermolecule hydrogel and a preparation method and application thereof. The structural formula of the chiral supermolecule hydrogel is shown in the specification, wherein R1 is H or COOEtOEtOH, and R2 is H or COOEtOEtOH. The invention also relates to the preparation method and application of the chiral supermolecule hydrogel. The chiral supermolecule hydrogel can be used as a cytoskeleton material; the process of regulating and controlling the cell selective adhesion by the chiral supermolecule hydrogel is carried out in physiological environment and is convenient to operate; the chiral supermolecule hydrogel has practical application value; the preparation method does not need complicated synthesis steps and is beneficial for large scale industrial production; the prepared product has high purity and good dispersibility, and is applicable to cell culture and controllable adhesives in commerce.

The invention designs and synthetizes a supermolecule polymer framework material. The supermolecule polymer framework material is formed through self assembly in cyclohexanol by using naphthalimide functionalized pillar [5] arene as a subject and bilateral quaternization pillar [5] arene as an object, wherein the mole ratio of the subject to the object is 1:1. Through competitive coordination mechanism, the supermolecule polymer framework material (SOF-AP5-MJP5) and a metal supermolecule polymer framework material (M-SOF-AP5-MJP5) can respectively realize continuous response and high-sensitivity detection to Fe<3+> and H2PO4<->; the recognition performance has important application values in the field of ion recognition.

The invention relates to a stable perovskite film and a preparation method thereof and an application of the perovskite film in photoelectric devices. According to the perovskite film, an anti-solventcontaining small organic molecules of a conjugated pi system is dropwise added in a one-step spin-coating preparation process, and a mixed layer of the small organic molecules and perovskite is formed after annealing. Through supermolecular cation-pi interaction between the small organic molecules of the conjugated pi system and cations in the perovskite, the defect of the perovskite film can begreatly reduced and the stability is significantly improved. Furthermore, the invention further provides the corresponding photoelectric devices, such as a perovskite cell, a light-emitting diode anda photoelectric detector, prepared by using the preparation method of the perovskite film. Compared with a standard device to which the small organic molecules of the conjugated pi system are not added, the obtained photoelectric devices have the advantages that the performance and the stability are improved.

The present invention provides an amphiphilic linear peptide and / or peptoid as well as a hydrogel that includes the amphiphilic linear peptide / peptoid. The amphiphilic linear peptide / peptoid is capable of forming a hydrogel. These peptides / peptoids include short amphiphilic sequences with a hydrophobic portion of aliphatic amino acids and at least one acidic, neutral, or basic polar amino acid. The amphiphilic linear peptide / peptoid is build up of non repetitive aliphatic amino acids, which may be in the L- or D-form. A plurality of such peptides / peptoids assembles to supramolecular helical fibers and forms peptide hydrogels after assembly. A corresponding hydrogel is formed in aqueous solutions at physiological pH and is thus useful for inter alia cell culture, tissue engineering, and drug release. Such hydrogels which are rigid, biocompatible and entrapping up to 99.9% of water are also well suited for applications utilizing electronic devices.

The invention discloses a force-induced response dynamic polymer. The polymer chain skeleton contains at least one force-sensitive group and at least one boron-free dynamic covalent bond, optionally contains at least one boron-containing dynamic covalent bond, and also optionally contains at least one supramolecular interaction; and under the action of mechanical force, the force-sensitive group in the dynamic polymer is subjected to chemical and / or physical change to realize force-induced response. According to the dynamic polymer, the force-sensitive group with a force-induced response characteristic, the boron-free dynamic covalent bonds with different dynamic properties, the optional boron-containing dynamic covalent bond and the supramolecular interaction are introduced, so that the force-induced response dynamic polymer material with a wide controllable range, a rich structure and various properties can be prepared. The force-induced response dynamic polymer can be widely appliedas a functional coating with a force-induced response function, a self-repairing material, an energy storage device material, an energy absorbing material, a photoelectric device material, a mechanical probe and the like.

The invention relates to a preparation method of beta-cyclodextrin-modified magnetic nano particles. A composite nano microsphere with a nuclear-shell structure is prepared. The composite nano microsphere with certain adsorption property is prepared by synthesizing magnetic ferroferric oxide nano particles by a hydrothermal method, then wrapping the nano particles by a layer of SiO2 by taking sodium silicate obtained by rice shell hydrolysis as a silicon source and modifying the surface by beta-CD. The composite nano microsphere has superparamagnetism with the magnetic particles and has subjective and objective clathration on cyclodextrin supermolecules; the nano microsphere with Fe3O4@SiO2 / beta-CD has great action on the environmental pollution treatment aspect under the excellent superparamagnetism and the supermolecule clathration.

The invention discloses a supramolecular hybrid peptide dendric macromolecule self-assembly and a preparation method and applications thereof. The supramolecular hybrid peptide dendric macromolecule self-assembly comprises an inorganic nanoparticle core and peptide dendritic macromolecules, wherein the peptide dendritic macromolecules are assembled at the periphery of inorganic nanoparticles by coordination interaction. Through the introduction of the coordination interaction, the peptide dendritic macromolecules are assembled on the surfaces of the inorganic nanoparticles. The coordination interaction is a relatively strong weak interaction, and an obtained supramolecular hybrid peptide dendric macromolecule self-assembly is stable in structure and good in dispersibility, and enriches the self-assembly strategy of dendritic macromolecules. By using the supramolecular self-assembly strategy, the spontaneous, rapid, green and efficient function integration of low-algebra dendritic macromolecules is realized, so that the highly branched structure of dendritic macromolecules is effectively amplified, and the function effect of the supramolecular hybrid peptide dendric macromolecule self-assembly reaches and is even higher than the function effect of classic high-algebra dendritic macromolecules.

The invention discloses a multilevel-structure hydrotalcite adsorbent and a preparation method thereof, and belongs to the technical field of synthesis of organic-inorganic supermolecule hybrid materials. The hydrotalcite adsorbent has an integral spherical fold structure which has a primary-particle platelike bending layer and a surfactant anion interlayer. The chemical formula is [M2+1-xM3+x(OH)2]x+(An-)x / n.mH2O, wherein An- is the interlayer anion, M2+ is Mg2+, M3+ is Al3+, and x is the mol ratio of M3+ / (M2++M3+). The preparation method is realized by adopting a urea static crystallization process in a way that: in a anionic surfactant water solution, under the interface induction action of the anionic surfactant vesicle template and the interlayer action between the hydrotalcite veneers, regulating the concentration, crystallization temperature and crystallization time of the anionic surfactant water solution to directly synthesize the multilevel-structure hydrotalcite adsorbent in one step. The multilevel-structure hydrotalcite adsorbent has excellent adsorbability for organic pollutants in the water solution.

The invention discloses a dynamic polymer thermoplastic elastomer. A polymer molecule of the thermoplastic elastomer comprises a multi-segment structure with multiple end segments and a single middlesegment, wherein the end segments are mutually mixed and / or can independently form a crystalline phase and / or a phase incompatible with the middle segment so as to form end segment-based reversible split-phase physical crosslinking; and the middle segment is in a amorphous state, partial chain segments of the middle segment contain at least one side group and / or side hydrogen bond groups on side chains, and the side hydrogen bond groups can form inter-chain supermolecule hydrogen bond dynamic crosslinking. By virtue of the dynamic reversibility of hydrogen bonds, the dynamic polymer thermoplastic elastomer has good tenacity, energy dissipation, self-repairing property and the like and can be widely applied to the fields of self-repairing sealing components, sealants, flexible elastomers and the like.

The invention discloses a synthesis method for increasing the Pd content of a metal organic framework based on Zr(IV) ions. The method comprises the following steps: performing a coordination polymerization reaction between an organic ligand (I) and ZrCl4, and performing post-synthesis modification of the product, wherein the post-synthesis modification comprises the following specific steps: enabling a coordination polymerization reaction product, 2-pyridylaldehyde or salicylaldehyde and a catalyst formic acid in a molar ratio of 1:(1-4):(0.1-0.3) to react in an organic solvent; performing centrifugal washing of the product and dispersing in an organic solvent; adding palladium nitrate in a molar ratio of 1:(0.8-1.2); after the reactions, centrifuging and drying to obtain powder; dispersing the obtained powder into water; adding sodium borohydride in a molar ratio of 1:(0.5-1.5); and after the reactions, centrifuging, washing and drying to obtain the product. In the invention, the synthesized compound is an organic-inorganic composite supermolecular material and has a metal organic framework which is easy to operate and low in cost and has nanoscale particle size; and the compound has very high efficiency when being used as a catalytic material for benzyl alcohol oxidation and benzaldehyde condensation.

The invention provides a conjugated metal polymer photoelectric material with functionalized polarity side-chain radicals and an application thereof. The material has conjugated main chains and functionalized polarity side-chain radicals, wherein the conjugated main chains contain Hg metal atoms; the functionalized polarity side-chain radicals comprise a high-polarity radical A with water-alcohol solubility. Due to the existence of the metal atoms in the conjugated main chains, the conjugated polymer material has the mutual metal-metal supermolecule function, and has a good current-carrier transferring characteristic; due to the existence of the radical A, the conjugated polymer material can be prepared by using a high-polarity solvent such as alcohol, can remarkably decrease the work function of a stable metal electrode, has good functions of suction filtration, injection and the like on enhanced high work function metal electrode electrons, and is applicable to manufacturing of complex multi-layer organic / polymer photoelectric devices. The conjugated metal polymer with the functionalized polarity side-chain radicals can be used as an electronic suction filtration / transferring layer to be applied to photovoltaic, light-emitting organic / polymer photoelectric devices to improve the properties of the devices.

The invention provides a preparation method and application of a temperature and oxidant dual stimuli responsive nano-aggregate. According to the invention, the redox inclusion principle of beta-cyclodextrin (beta-CD) and ferrocene (Fc) and the temperature sensitive properties of the polymer poly(N-isopropylacrylamide) (PNIPAM) are utilized to connect PNIPAM-beta-CD with the end containing a beta-CD host group to hydrophilic polyethylene glycol (mPEG-Fc) with the end modified by an Fc guest group in a water solution through a host-guest recognized noncovalent bond, thus forming a supramolecular complex mPEG-Fc / PNIPAM-beta-CD. When the temperature is higher than the LCST (lower critical solution temperature) of PNIPAM, the macromolecular adduct can further gather in water to form a micellar structure. Micelle formation and disintegration can be realized by adjusting the solution temperature and adding an oxidant. cytotoxicity assessment experiments find that the supramolecular complex has very good biocompatibility. The supramolecular micelle packing the anticancer drug doxorubicin has very good effect in inhibiting A549 tumor cell growth. The preparation method of the nano-aggregate is simple, environment-friendly and economical, and the nano-aggregate has great application value in the field of biological medicine.

The invention relates to a method for improving the natamycin action efficiency. The method comprises the following steps: taking cyclodextrin and derivatives as the supermolecule host compounds to prepare a natamycin / cyclodextrin supermolecule clathrate; and keeping the bacteriostatic activity of natamycin and improving the water solubility and stability of natamycin. The preparation method for the natamycin / cyclodextrin supermolecule clathrate comprises the following steps: preparing an aqueous solution of the cyclodextrin and the derivatives through ultra pure water to reach certain solubility; adding a certain amount of natamycin into the aqueous solution of the cyclodextrin and the derivatives, and carrying out ultrasonic treatment for 5 minutes to improve the complexation efficiency; and covering a layer of aluminum-foil paper on the container of the suspension, placing the container on a shaking table at a room temperature for reaction, and obtaining the homogenous solution of the natamycin / cyclodextrin supermolecule clathrate after reaching the balance. The method has the advantages of improving the solubility and stability of natamycin in the aqueous solution, improving the natamycin bioavailability, solving the problem of poor water solubility of natamycin, and improving the action efficiency of the biological bacteriocide natamycin.

The invention discloses an ultramolecular gelator MP5 based on naphthalimide functional column 5 arene. The gelator can form organic ultramolecular gel MP5-G with yellow aggregation induced fluorescence in a cyclohexanol solution under the action of pi-pi; the organic ultramolecular gel can be used for detecting Fe<3+> with high selectivity and super sensitivity: when ions such as Fe<3+>, Hg<2+>,Ag<+>, Ca<2+>, Cu<2+>, Co<2+>, Ni<2+>, Cd<2+>, Pb<2+>, Zn<2+>, Cr<3+> and Mg<2+> are added into the MP5-G, fluorescence is quenched only by the Fe<3+>, and stable metal gel MP5-FeG is formed. When L-Cys is added into the fluorescence-quenched metal gel, the L-Cys and the Fe<3+> are complexed to recover the pi-pi action again among the MP5-G, so that aggregation induced fluorescence appears again,and continuous reversible ultrasensitive detection of the Fe<3+> and the L-Cys is realized.