The invention relates to a reactive self-adhered ethylene-propylene-diene monomer waterproof roll which consists of a surface waterproof layer, a middle self-adhering layer and a bottom isolating layer, wherein the surface waterproof layer is formed by co-mixing ethylene-propylene-diene monomer rubber, zinc oxide, sulfur, stearic acid, highly wear-resistant carbon black, processing oil and an accelerator DM, the middle self-adhering layer is an active self-adhered sizing material which is formed by co-mixing asphalt, a softener, a tackifier, butyl rubber IIR (Isobutylene-Isoprene Rubber), butadiene styrene rubber, an activator and filler, and the bottom isolating layer is a PET (Polyethylene Terephthalate) thin film. As the middle self-adhering layer which contains asphalt and active macromolecular active components and has the active reactive self-adhered sizing material is arranged in the upper layer on the inner surface of the surface waterproof layer which takes ethylene-propylene-diene monomer as a main material, so that edges of the roll and the roll and the base layer of concrete are directly adhered by the middle self-adhering layer without any adhesives in match. The generated waterproof layer has a service life effect which is equal to that of a main body material, so that the roll is an ideal upgrading product of existing single ethylene-propylene-diene monomer waterproof roll.