Double-network hydrogel based on PEG (polyethylene glycol) and polysaccharides as well as preparation method and application of double-network hydrogel

A hydrogel and double-network technology, applied in the field of double-network hydrogel based on PEG and polysaccharides and its preparation, can solve problems such as inability to prepare shapes, achieve rapid recovery and reorganization, excellent biocompatibility, and The effect of reversibility

Active Publication Date: 2017-03-22
深圳宁聚生物新材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The double-network hydrogel still involves multi-step reactions in the preparation process, and various complex shapes cannot be prepared, and free radical polymerization will introduce toxic substances

Method used

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  • Double-network hydrogel based on PEG (polyethylene glycol) and polysaccharides as well as preparation method and application of double-network hydrogel
  • Double-network hydrogel based on PEG (polyethylene glycol) and polysaccharides as well as preparation method and application of double-network hydrogel
  • Double-network hydrogel based on PEG (polyethylene glycol) and polysaccharides as well as preparation method and application of double-network hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] (1) Weigh 200 mg of high-strength agarose and dissolve it in 10 mL of PBS buffer solution, heat to 120 ° C and cool to 50 ° C, take 5 mL and add 400 mg of four-armed polyethylene glycol amino (as shown in formula II, wherein, n is 56, R 1 is an ether bond, R 2 is amino) and 400mg four-arm polyethylene glycol succinimide ester (as shown in formula II, wherein, n is 56, R 1 is an ester bond, R 2 succinimide ester) to obtain mixed solution 1 and mixed solution 2; draw a mixed solution with one of the double-barreled syringes respectively, then inject it into a glass mold, and wait for cooling to room temperature for 3 hours to obtain chemical-physical double network water gel.

[0074] The obtained chemical-physical double network hydrogel was tested, and the compressive strength was 28MPa, and the compressive deformation rate was over 97%.

[0075] After the gel prepared in this example is compressed, it can recover to the original compressive strength after being hea...

Embodiment 2

[0077] Weigh 200 mg of conventional agarose and dissolve in 10 mL of PBS buffer solution, heat to 100 ° C and cool to 50 ° C, respectively take 5 mL and add 400 mg of four-arm polyethylene glycol alkynyl (as shown in formula II, wherein n is 56 , R 1 is an ether bond, R 2 is alkynyl) and 400mg four-arm carboxy azide (as shown in formula II, wherein, n is 56, R 1 is an ether bond, R 2 azide) to obtain mixed solution 1 and mixed solution 2; draw a mixed solution with one of the double-barreled syringes respectively, then inject it into a mold, and wait for cooling to room temperature for 2 hours to obtain a chemical-physical double network hydrogel.

[0078] Different shapes of hydrogels can be obtained by using different molds, such as figure 2 As shown, clover-shaped and snowflake-shaped hydrogels can be prepared.

Embodiment 3

[0080] Weigh 200 mg of low-melting point agarose and dissolve in 10 mL of PBS buffer solution, heat to 80 ° C and cool to 50 ° C, respectively take 5 mL and add 400 mg of four-armed polyethylene glycol thiol (as shown in formula II, wherein n is 56 , R 1 is an ether bond, R 2 is mercapto) and 400mg four-arm polyethylene glycol succinimide ester (as shown in formula II, wherein, n is 56, R 1 is an ester bond, R 2 succinimide ester) to obtain mixed solution 1 and mixed solution 2; use one of the double-barreled syringes to draw a mixed solution, then inject it into the mold, and wait for cooling to room temperature for 4 hours to obtain the chemical-physical double network hydrogel glue.

[0081] The obtained chemical-physical double network hydrogel was tested, and the compressive strength was 38MPa, and the compressive deformation rate was over 98%. After the gel is compressed, it can recover to its original compressive strength by heating to 60°C for 2 hours.

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Abstract

The invention discloses a double-network hydrogel based on PEG (polyethylene glycol) and polysaccharides as well as a preparation method and an application of the double-network hydrogel. The chemical-physical/chemical double-network hydrogel is formed under the hydrogen bond interaction between a first chemical network and a second physical/chemical network; the first chemical network is formed by a chemical reaction of a PEG derivative 1 and a PEG derivative 2; the second physical/chemical network is formed by either crosslinking of polysaccharides or derivatives thereof or by interaction between the polysaccharides or derivatives thereof and a crosslinking agent. The high-strength chemical-physical/chemical double-network hydrogel with good self-recovery capability and good biocompatibility has potential application in the following fields: drug sustained-release materials, tissue engineering scaffolds, medical sponge, medical implants and surface coatings of the medical implants.

Description

technical field [0001] The invention relates to a double-network hydrogel, in particular to a double-network hydrogel based on PEG and polysaccharide, a preparation method and application thereof. Background technique [0002] Hydrogel is a soft material that can absorb a large amount of water and has a three-dimensional network structure. Hydrogels are widely used in fields such as biomedicine, agriculture, industry, and environmental protection because of their high water absorption and good biocompatibility. In terms of biomedicine, hydrogels have been used in drug carriers, cell carriers, dressings, masks, and artificial corneas. However, for load-bearing soft tissues such as cartilage, tendons and ligaments, traditional hydrogels cannot meet the requirements. [0003] In recent years, double network gels with high mechanical properties have received extensive attention and become one of the research hotspots in hydrogels. The so-called double-network hydrogel (Double...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L71/02C08L5/12C08L5/04C08L5/08A61K47/36A61K47/38A61L27/20A61L27/52A61L24/08A61L24/00A61L31/04A61L31/10A61L31/14
CPCA61K47/36A61K47/38A61L24/0031A61L24/08A61L27/20A61L27/52A61L31/042A61L31/10A61L31/145C08J3/075C08L71/02C08L2203/02C08L2205/025C08L2205/03C08L5/12C08L5/04C08L5/08C08L1/02C08L3/02
Inventor 吴德成补亚忠
Owner 深圳宁聚生物新材料科技有限公司
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