304 results about "Double network" patented technology

The invention is suitable for the technical field of materials, and provides a binderless fiberboard and a preparation method thereof.The preparation method comprises the steps that wood fibers are subjected to oxidation treatment, and an intermediate is obtained; placing the intermediate in a metal ion solution for non-covalent bond coordination treatment, extruding the solution, and adding polyphenol into the fiber for chelation to obtain a chelated fiber; and assembling the chelate fibers into a plate blank, and carrying out hot pressing treatment to obtain the product. Metal ions and lignin hydroxyl are bonded and coordinated through an activation method, then the metal ions and polyphenol are chelated to form self-adhesion, meanwhile, the non-adhesive fiberboard formed by tightly interweaving and stacking the fibers can reach the national standard in mechanical strength and water absorption expansion rate, the preparation method is simple and easy to implement, raw materials are easy to obtain, and the production cost is low. The method is suitable for mass production; by means of the formed double-network structure, the binderless fiberboard is more compact, higher in stability and excellent in internal bonding strength, bending strength and other mechanical properties. Zero formaldehyde release of the fiberboard is achieved, and the cost is lower.

The invention discloses hyaluronic acid / alginic acid dual-network hydrogel as well as a preparation method and application thereof. The hyaluronic acid / alginic acid double-network hydrogel comprises a first network and a second network which are not crosslinked with each other, and the first network and the second network are distributed in the hydrogel in an interpenetrating manner; the first network comprises an ionic cross-linked network of alginic acid with cell adhesion sites and calcium ions, and the second network comprises a chemical cross-linked network formed by covalent cross-linking of methacrylic anhydride modified hyaluronic acid. The hyaluronic acid / alginic acid double-network hydrogel disclosed by the invention is short in curing time, supports three-dimensional spreading of cells and formation of capillary lumens, has good mechanical stability, and has good application prospects in the aspects of three-dimensional culture of the cells, tissue engineering construction and the like.

The invention relates to the technical field of metal material surface treatment, in particular to an antifouling and anti-drag coating for titanium alloy pipeline binding force and a preparation method and application of the antifouling and anti-drag coating. The preparation method comprises the following steps: carrying out micro-arc oxidation treatment on a titanium alloy to form a ceramic film on the surface of the titanium alloy; the titanium alloy subjected to micro-arc oxidation treatment is subjected to a hydrothermal reaction, and a nanoscale porous thorn microstructure and hydroxyl are introduced to the surface of a ceramic membrane; coating the pre-polymerization liquid on the titanium alloy subjected to hydrothermal treatment, and performing irradiation reaction under ultraviolet light to obtain first network gel; the first network gel is soaked in a beta-sodium glycerophosphate solution, and the ion-covalent double network p (SBMA-co-AAc) / CS-beta-GP DN hydrogel is formed. The stability and durability of the coating prepared by the preparation method provided by the invention are improved, and the coating has long-term stable anti-fouling performance, is strongly combined with a titanium alloy substrate, and has excellent anti-fouling effect and anti-drag effect when being applied to the titanium alloy substrate.

The invention relates to the technical field of water adsorption materials, in particular to an aluminum-based MOF composite adsorbent and a preparation method and application thereof.The aluminum-based MOF composite adsorbent is obtained by weighing Al-MOF, adding the Al-MOF into a lithium chloride solution, conducting ultrasonic dispersion, stirring, filtering and drying at the temperature of 80-120 DEG C; adding sodium alginate and carrageenan into deionized water, and stirring to obtain double-network hydrogel; and adding the double-network hydrogel into the aluminum-based MOF adsorbent, uniformly mixing, forming by pelleting equipment to prepare adsorbent particles, and drying the adsorbent particles at the temperature of 80-120 DEG C to obtain the aluminum-based MOF composite adsorbent. According to the invention, Al-MOF, sodium alginate and carrageenan are mixed and molded, so that a high-strength hydrogel network can be obtained, and Al < 3 + > in an MOF skeleton and functional groups in sodium alginate and carrageenan in the dual-network hydrogel are coordinated, so that the network structure is tighter and more stable; the free movement of water molecules in the hydrogel can be effectively limited, so that the swelling property and the mechanical stability of the hydrogel are further adjusted.

The invention belongs to the technical field of biomedical materials, and particularly relates to preparation of a hydrogel ultrasonic coupling patch for long-term stable continuous monitoring. According to the patch, an interpenetrating double-network structure system is formed by an alginate component and a polyacrylic acid component through intermolecular interaction, and the patch has excellent adhesion performance and mechanical performance. Compared with the prior art, by optimizing the components and the preparation process, the obtained hydrogel patch has the following advantages that the excellent acoustic impedance matching characteristic is achieved, and high-fidelity transmission of ultrasonic signals is ensured; the tissue adhesion is strong, and long-term stable attachment can be realized; good mechanical stability and durability are achieved, and the method is suitable for continuous monitoring application. The product effectively solves the technical problems that the traditional liquid coupling agent is easy to lose, the solid coupling patch is insufficient in adhesion and the like, and has important application value in the fields of medical ultrasonic diagnosis and long-term monitoring.

The invention discloses a green construction of a porous separation membrane and an efficient uranium separation / enrichment method thereof.The method comprises the steps that firstly, mixed-dimension attapulgite clay acid etching powder is modified through phytic acid and then added into a saponin plant extracting solution, and then the mixture is mixed with a sodium alginate-chitosan double-network matrix; a film-forming solution with a high-mechanical-stability gas-liquid interface is obtained through a Pickering foam template method, and then the porous separation film is controllably constructed through cooperative strategies such as film casting, calcium cross-linking and carboxylation. Based on the advantages of a rod / sheet mixed dimension structure of minerals, synergistic interaction of plant derivatives and a spatial orientation regulation and control synergistic mechanism of functional groups, a porous separation membrane with a specific porous structure, excellent mechanical properties and uranium separation efficiency is constructed in a green manner, and the uranium separation efficiency is improved by combining optimization of membrane layer stacking and elution strategies. A high-efficiency uranium separation / enrichment method is developed, and a new normal form is provided for solving uranium pollution prevention and control and resource recovery and enrichment by a membrane separation technology.

The invention discloses preparation and application of dual-network hydrogel. The dual-network hydrogel comprises the following components: (Z1) a spinal cord acellular matrix network DSM formed by self-assembly of a spinal cord acellular matrix dSECM; and (Z2) a metal-polyphenol network MPN formed by coordination of metal ions and polyphenols; wherein the DSM and the MPN are cross-linked through hydrogen bonds to jointly form a double-network structure. DSM provides a microenvironment suitable for cell survival and growth for the dual-network hydrogel and induces stem cells to differentiate into neurons, and MPN provides the dual-network hydrogel with biological effects of inhibiting inflammation and accumulation of reactive oxygen species (ROS). The dual-network hydrogel has the advantages of the two components, the active component neurotrophic factor and the inhibitor loaded on the dual-network hydrogel can regulate and control immune response after SCI, improve neuroinflammation microenvironment and promote nerve repair, and a new strategy is provided for in-situ tissue repair of SCI.

The invention discloses an LED (light-emitting diode) pouring sealant which is prepared from the following components: alicyclic epoxy resin, a glycidyl ether toughening agent, a thermal initiation cation curing agent, an anhydride curing agent and the like. A rigid ring structure of the alicyclic epoxy resin and a flexible chain segment of the anhydride curing agent are subjected to ring-opening reaction to form a three-dimensional cross-linked network; the alicyclic epoxy resin and the anhydride curing agent are combined to form an interpenetrating polymer network, the anhydride curing agent is further crosslinked through an esterification reaction in a high-temperature stage to form a high-density interpenetrating network, and the structure not only retains the weather resistance of the alicyclic epoxy resin, but also relieves internal stress through a flexible chain segment of anhydride, so that the volume shrinkage rate after curing is reduced to 0.5% or below; meanwhile, a glycidyl ether toughening agent is inserted into double networks through long-chain ether bonds to form tough nodes, crack propagation is inhibited, and the comprehensive performance of the colloid is remarkably improved by combining an anhydride curing agent vacuum dehydration and staged curing process.

The invention discloses silicone rubber and a preparation method thereof, and belongs to the technical field of silicone rubber, and the silicone rubber is prepared from the following raw materials: raw vinyl silicone rubber, zinc acrylate, a platinum catalyst, a hydrogen-containing silicone oil cross-linking agent and silicon carbide nanowires. According to the invention, a covalent network based on raw vinyl silicone rubber is constructed in the silicone rubber, and zinc acrylate and silicon carbide nanowires form an ionic network, so that the double-network structure not only can improve the technical problem of high probability of rubber overflow in the preparation process of the silicone rubber, but also can enable the silicone rubber to obtain better mechanical properties.

The invention discloses a novel keratin-based dual-network hydrogel dressing as well as a preparation method and application thereof. The preparation method comprises the following steps: cross-linking chitosan, halloysite nanotubes and keratin to form a first network structure; tannic acid is introduced for further dynamic crosslinking with chitosan molecules, and a second network structure is formed; and freezing and drying to obtain the keratin-based double-network hydrogel dressing. According to the method, a freeze-drying technology is adopted, feather keratin (KP), halloysite nanotubes (HNTs) and chitosan (CS) are utilized, and the double-net-shaped hydrogel dressing which has rapid and effective hemostatic performance, antibacterial activity and biocompatibility and can promote healing is prepared. And a novel and efficient method is provided for wound healing.

The present invention discloses a preparation method and application of a supercapacitor electrode material. Iron ions and ethylenediamine are used as crosslinking agents, and a physical and chemical double crosslinking method is adopted to construct a semi-interpenetrating double network hydrogel structure using carboxylated nanocellulose (TOCNFs) and sodium lignin sulfonate (SL). The prepared double network hydrogel is then freeze-dried and carbonized to prepare a nitrogen-doped porous carbon aerogel, and then a hydrothermal reaction is used to synthesize manganese dioxide (MnO2) on the surface of the carbon aerogel. Finally, the prepared material is etched by the reaction of oxalic acid and MnO2. The present invention is simple to operate, low in cost, and the raw materials used are green and environmentally friendly. The electrode material prepared by this method has good structural stability and excellent electrochemical properties, and can be used in high-performance all-solid-state supercapacitors.

Cell engineering, soft robotics and wearable electronics often desire soft materials that are easy to deform, self-heal, and relax stress. Hydrogel, a type of hydrophilic networks, which can be made responsive to environmental stimuli, are often used in the aforementioned applications. However, conventional hydrogels often suffer from poor stretchability and repairability. Here, we report hydrogels consisting of boronic ester dynamic covalent bonds in a double network of poly(vinyl alcohol) together with chitosan, demonstrating extreme stretchability (up to 310 times of the original length), instant self-healing (within 5 sec), reusability as well as inherent adhesion. Their instant stress relaxation as a result of low activation energy of the boronic ester bond exchange (less than 20 KJ / mol) contributes to the extreme stretchability and self-healing behaviors. The hydrophilic environment readily incorporates various additives and provide opportunities in conductive soft materials, bio-signaling, and soft artificial joint.

The invention relates to a differentiated'inner core and outer sheath 'triboelectric stimulation bionic nerve graft and a preparation method thereof. The nerve graft is composed of an outer sheath layer and an inner core layer. Wherein an outer sheath layer is a calcium ion cross-linked waterborne polyurethane / sodium alginate double-network structure hollow conduit, and an inner core layer is oriented conductive polymer / silk fibroin nanofibers. The nerve graft provided by the invention is provided with the sheath part with an internal and external differential gradient hole structure and the bionic inner core similar to a natural nerve structure, when the nerve graft is implanted into a body, the inner core and the outer sheath show differential degradation speeds and hydrophilic-hydrophobic properties, and can generate electrical stimulation synchronously responding to physiological activities, so that regeneration after nerve injury is facilitated.

The invention relates to a rapid self-gelation modified gelatin-based styptic powder composition as well as a preparation method and application thereof. The styptic powder is composed of phenylboronic acid modified gelatin and a long-chain polymer containing a diol structure, and can be used independently or matched with thrombin or polyethylene glycol active derivative powder to prepare a composition for use. Under physiological conditions, the powder can rapidly absorb blood, settle and self-crosslink to form hydrogel, activate an endogenous hemostasis pathway and perform physical plugging, and rapid hemostasis is realized. When used together with thrombin, the medicine can maintain local high concentration and accelerate blood clot formation, and is suitable for emergency control of massive hemorrhage. When the hydrogel is combined with a polyethylene glycol active derivative, tissue adhesion and a dual-network structure can be realized, the gel strength is improved, and long-acting hemostasis is realized.

The invention relates to high-strength degradable self-healing hydrogel and a preparation method thereof, and belongs to the technical field of high polymer materials. The hydrogel is prepared from the following components in percentage by mass: 15 to 20 percent of carboxymethyl cellulose, 10 to 14 percent of acrylic acid, 15 to 20 percent of N-isopropylacrylamide, 4 to 8 percent of tannic acid, 2 to 4 percent of borax, 0.06 to 0.1 percent of laccase, 0.5 to 1 percent of N, N-methylene bisacrylamide, 0.4 to 0.6 percent of potassium persulfate and the balance of phosphate buffer solution. According to the hydrogel disclosed by the invention, through dual-network structure design, dynamic covalent bond crosslinking and enzyme catalysis green synthesis, collaborative optimization of high strength, high self-healing property, degradability and multi-responsiveness is realized, and the problems of poor mechanical property, low repairing efficiency, environmental unfriendliness and the like of traditional hydrogel are solved; the method has wide application potential in the fields of biomedicine, flexible electronics, intelligent packaging and the like.

The invention discloses a biological gel electrode based on polyvinyl alcohol and gelatin double-network crosslinking as well as a preparation method and application of the biological gel electrode, and belongs to the technical field of conductive hydrogel. According to the method, polyvinyl alcohol, gelatin, liquid metal, poly (3, 4-ethylenedioxythiophene)-polystyrolsulfon acid (PEDOT: PSS) and the like are used as main raw materials. Wherein the liquid metal gallium indium alloy is a conductive filler, sodium tetraborate is used as a cross-linking agent, and the biological double-network structure gel electrode with excellent conductivity, relatively low skin impedance and relatively good self-healing is obtained. As a biological electrode patch, the hydrogel prepared by the invention can be used for long-time and high-fidelity electrophysiological electrical signal acquisition, such as electrocardiosignals, electromyographic signals, electroencephalogram signals and the like. In addition, the biogel electrode provided by the invention is simple in preparation process, low in cost and good in biocompatibility, and has huge potential in the aspects of large-scale production, popularization and application of electrode patches.

An organic-inorganic composite admixture, its preparation method and its application in a calcined clay-limestone low-carbon cement system. The organic-inorganic composite admixture is prepared by free radical copolymerization of unsaturated carboxylic acid, 2-acrylamido-2-methylpropanesulfonic acid, methacryloylpropyltrimethylammonium chloride or acryloylpropyltrimethylammonium chloride, maleic anhydride grafted β-cyclodextrin, an oxidizing agent and a reducing agent, and then by electrostatic assembly reaction with POM polyoxometalate. In the present invention, a spatial cross-linked double network structure is formed through the characteristics of the β-cyclodextrin and polyoxometalate POM structures, resulting in a large steric hindrance and forming a sufficiently thick adsorption layer, which hinders the competitive adsorption of the clay on the admixture; double adsorption sites are formed through the carboxyl and sulfonic acid groups on the main chain and side chains, further enhancing the dispersion ability of the admixture in the LC 3 system, and finally achieving the characteristics of low dosage, high water reduction rate and excellent slump retention performance.

The invention discloses a preparation method of an in-situ self-generated diaphragm type dual-network polymer electrolyte and a battery, and belongs to the technical field of lithium batteries. A staged in-situ polymerization strategy is adopted and comprises the following steps: firstly, applying a precursor solution containing an acrylate monomer, a polythiol cross-linking agent, a cyclic ether monomer, an initiator and a lithium salt to the surface of an electrode, partially polymerizing the solution under first initiation conditions such as transient ultraviolet irradiation and the like, and generating a layer of semi-solid gel diaphragm on the surface of the electrode in situ; then, an electrode with the gel diaphragm and a counter electrode are safely assembled into a battery; and finally, under second initiation conditions such as room temperature curing and the like, integrally curing and forming the dual-network polymer electrolyte in the battery. According to the method disclosed by the invention, physical isolation is realized by ingeniously utilizing the intermediate-state gel diaphragm, and the prepared electrolyte has high ionic conductivity, high mechanical strength and excellent interface stability, so that the assembled diaphragm-free solid-state lithium battery shows ultra-long cycle life.

The invention discloses a method for in-situ rapid growth of a dual-network hydrogel coating on the surface of a base material by a one-step method, which comprises the following steps: putting the base material with an adhesion initiation layer on the surface into a hydrogel precursor solution, and carrying out in-situ polymerization for 0.1-10 minutes under light irradiation, wherein the adhesion initiation layer comprises an adhesive compound based on a catechol group and a first photoinitiator, and the hydrogel precursor solution comprises a natural polymer containing tyrosine, an acrylic monomer, a cross-linking agent and a second photoinitiator, and wherein the first photoinitiator and the second photoinitiator are different from each other and are independently selected from a divalent ruthenium compound and a persulfate. Compared with the prior art, the natural / synthetic polymer double-network gel coating with biological activity and mechanical property can grow on the surfaces of different substrates more quickly and efficiently through a one-step method; and the base material, the surface of which is modified by the in-situ grown double-network hydrogel coating, obtained by the method can be applied to in-vivo medical apparatuses and instruments.

The invention provides multifunctional bionic hydrogel as well as preparation and application thereof in traumatic brain injury treatment, and belongs to the field of biomedical materials. The preparation method comprises the following steps: combining polydopamine modified hemoglobin nanoparticles with curcumin-based carbon quantum dots with anti-inflammatory activity, and embedding into bionic hyaluronic acid-collagen double-network hydrogel, so as to prepare the multifunctional bionic hydrogel. The hydrogel can effectively relieve neuron hypoxia, reduce apoptosis, promote the polarity of microglial cells to be converted into anti-inflammatory phenotype, and significantly down-regulate the expression of S100A8, thereby inhibiting pathological neural immune crosstalk. In a traumatic brain injury model, hydrogel implantation improves the pathological microenvironment, enhances endogenous nerve regeneration, and ultimately results in significant neurological function and cognitive recovery. The multifunctional bionic hydrogel prepared by the invention has a good application prospect in preparation of materials for preventing and / or treating traumatic brain injury.

The invention discloses a flexible and stable three-layer porous structure hemostatic dressing and a preparation method thereof, and belongs to the technical field of biological medicine. The preparation method of the hemostatic dressing comprises the following steps: constructing a stable foaming system by using protein and polysaccharide, constructing a dual three-dimensional network by combining multi-source polysaccharide and tannic acid, and designing a large-area dressing structure by overlapping the dual three-dimensional network with cotton gauze; carrying out Ca < 2 + > cross-linking impregnation and freeze drying in a weak acid environment to prepare an integrally formed three-layer dual-network multi-source porous structure dressing; the dressing has three layers of different structures, has an extremely fast hemostatic effect, reduces the amount of bleeding, can effectively maintain the humidity of a wound, avoids invasion and infection of bacteria, and can quickly and effectively sterilize; good shape maintaining and recovering capability is realized; meanwhile, the advantages of the porous structure and the cotton gauze are integrated, the structure is enriched, the structural stability of the large-area dressing is improved, the dressing can be stored for a long time in a normal-temperature environment, and the physical basic performance of the dressing meets the requirements of medical dressings.

The invention discloses a pure zwitter-ion dual-network hydrogel coating and a preparation method and application thereof, firstly, a PU substrate is immersed in an acetone solution of a hydrophobic photoinitiator 2959, at the moment, the photoinitiator 2959 is diffused into the swollen PU substrate, and a 2959-PU diffusion layer is formed; then, SBMA monomers in a first network pSBMA precursor solution (high monomer concentration and low cross-linking agent proportion) spread on the surface permeate into the 2959-PU diffusion layer, and under the condition of ultraviolet irradiation, pre-gel solutions between interfaces and on the surface are polymerized at the same time to form a firm pSBMA single-network hydrogel coating (pSBSN-PU). Wherein the hydrophilic photoinitiator 1173 is used for forming pSB hydrogel, the hydrophobic photoinitiator 2959 is used for mediating polymerization of an SBMA monomer in an interface and forming a winding structure with a PU chain, and firm adhesion of the coating is due to chain entanglement of pSBMA and a PU substrate.

The invention discloses an antibacterial-waterproof hydrogel biosensor based on a conductive spandex fiber net and a preparation method of the antibacterial-waterproof hydrogel biosensor. The preparation method comprises the following steps: (1) preparing graphene composite elastic spandex conductive fibers by adopting a solution dry spinning method, and weaving the graphene composite elastic spandex conductive fibers into a fiber net; (2) designing a cuboid-shaped mold, and fixing a fiber net on hooks on four edges in a mold groove to serve as a first layer of conductive fiber net structure; (3) preparing a sodium alginate / acrylamide mixed solution blended with nano-silver, and pouring the sodium alginate / acrylamide mixed solution into a mold for in-situ polymerization; 4) transferring the mold into a Ca < 2 + > coagulating bath to form a second layer of gel matrix structure with double networks; and 5) after the gel is completely dialyzed, dipping the gel in a stearic acid / organic silicon emulsion / vegetable oil mixed solution for hydrophobic modification so as to form a third waterproof layer structure on the surface of the gel, and finally obtaining the hydrogel biosensor. The biosensor has conductive, stretchable, antibacterial and waterproof functions and the like, and can be applied to biological strain monitoring.

The invention discloses a flexible self-repairing pressure sensor and a preparation method and application thereof.A conductive hydrogel part of the sensor uses a polyvinyl alcohol and gelatin dual-network as a flexible base material, a borate dynamic covalent bond as a self-repairing bridge, and a helical carbon nanotube with silver chemically deposited on the surface as a conductive filler; and packaging with a copper electrode and an insulating tape to obtain the self-repairable flexible piezoresistive pressure sensor. The conductive network of the hydrogel is deformed by applying an external force, so that a resistance change signal of the hydrogel is formed, a physiological signal of a human body is monitored, and the hydrogel becomes one of elements of the flexible wearable electronic equipment.

The invention belongs to the technical field of nano materials and environment-friendly functional coatings, and discloses a preparation method and application of a lignin-based super-hydrophobic coating. The method comprises the steps that lignin is pretreated with ethylene carbonate to break steric hindrance and improve the grafting rate, then hexadecyl trimethoxy silane is added for grafting to form a hydrophobic chain, and surface energy is reduced; then adding silicon dioxide and N, N-dimethylformamide, carrying out ultrasonic dispersion to synergistically construct a micro-nano coarse structure, spraying the micro-nano coarse structure on a base material by using a spraying method, and putting the base material into a drying oven for curing, so as to obtain the lignin-based super-hydrophobic coating material. According to the method disclosed by the invention, a high-activity epoxy group is grafted on a lignin skeleton through ethylene carbonate pretreatment, so that steric hindrance in a three-dimensional space is broken, and dense anchor points are provided for a subsequent hydrophobic chain; then cocondensing with hexadecyl trimethoxy silane to form an alkyl-siloxane double network, and cooperating with nano silicon dioxide to construct micro-nano double roughness, so that a stable super-hydrophobic core under a fluorine-free condition is realized, and the technical route is simple and efficient.

The preparation method comprises the following steps: by taking an oriented polylactic acid nanofiber membrane as a raw material, carrying out homogenization treatment to obtain polylactic acid piezoelectric short fibers; gelMA is used as a skeleton matrix, polylactic acid short fibers, LAP and DRG cells are compounded, a 0 / 90-degree alternate grid structure scaffold is constructed through pneumatic extrusion type biological printing, and the dual-network piezoelectric biological scaffold is formed through blue light crosslinking curing. The piezoelectric effect of polylactic acid short fibers is activated through ultrasonic stimulation, mechanical energy is converted into local electric signals, loaded DRG cells are directly driven to secrete CGRP in situ, macrophages are dynamically regulated and controlled to be polarized to M2 anti-inflammatory phenotypes, nerve-immune microenvironment disorder of diabetic bone defects is corrected, vascularization and bone regeneration are promoted, and the diabetic bone defect treatment effect is improved. The problems of short delivery half-life period of traditional cell factors, difficulty in nerve function reconstruction and chronic inflammation caused by non-degradable piezoelectric materials are solved, and non-invasive and degradable precise bone repair is realized.

This invention discloses a composite hydrogel based on a polysaccharide-based hybrid dual network, its preparation method, and its applications, belonging to the field of marine polysaccharide technology. Based on the important role of amorphous calcium phosphate, a precursor in biomineral formation, in mineralization, this invention prepares a multifunctional composite hydrogel with wet bonding, antibacterial, and remineralization functions. This composite hydrogel can achieve rapid and convenient repair of enamel demineralization. This invention prepares oxidized sodium alginate via an alcohol-aqueous phase using the sodium periodate method. Sodium alginate reacts with carboxymethyl chitosan and dopamine through a Schiff base reaction to form dynamic imine bonds, thus preparing an in-situ self-crosslinking hydrogel. Simultaneously, amorphous calcium phosphate is introduced for secondary crosslinking, preparing a dense dual-network composite hydrogel. The composite hydrogel prepared by this invention has an interconnected three-dimensional porous structure, stable mechanical properties, and uniformly dispersed amorphous calcium phosphate in the form of nanospheres. The composite hydrogel prepared by this invention provides an integrated strategy with clinical translational potential for orthodontic enamel demineralization, with broad market prospects.

The present application relates to the technical field of hydrogel, in particular to an injectable temperature-responsive enhanced composite double-network magnetic particle gel, a preparation method and application thereof, the hydrogel is composed of a particle gel network formed by gelatin nanoparticles and Fe3O4 nanoparticles through electrostatic interaction and a poly-N-isopropyl acrylamide (PNIPAM) based temperature-sensitive polymer gel network. At room temperature, the hydrogel has excellent shear thinning and self-healing properties, and can be easily injected through a needle and a microcatheter. When the temperature rises to human body temperature (37 DEG C), the temperature-sensitive polymer phase transition crosslinking enhances the mechanical properties of the gel network. The hydrogel is injectable in vitro, temperature-responsive in vivo, meets the requirements of vascular interventional embolization materials, and can be magnetically heated under an alternating magnetic field, and is used for liver cancer embolization combined with magnetic heating treatment. The preparation method is simple, has high biocompatibility, and has great clinical application potential.

The invention relates to the technical field of composite films, and particularly discloses a high-fastness colored high-brightness composite film packaging material manufacturing process which comprises the steps of S1, base film preparation and pretreatment, S2, surface activation treatment, S3, colored coating preparation, S4, coating, S5, gradient drying and curing and S6, curing. Through corona and twice plasma treatment of different gases, oxygen-containing, amino and fluorine-containing groups are synergistically introduced to the surface of a base membrane, the chemical bonding and hydrogen bonding effects of a coating and the base membrane are enhanced, a composite system of epoxy resin, hydroxy acrylic resin and polyurea resin is adopted, and modified carbon black with the aminated surface is matched, so that the coating has a good anti-corrosion effect on the surface of the base membrane. Under the action of a catalyst and a cross-linking agent, a compact chemical cross-linking and hydrogen bond physical cross-linking dual-network structure is formed; and gradient heating drying and low-temperature curing processes are combined, so that stable volatilization of the solvent and full and complete cross-linking reaction are ensured, and the adhesive force and wear resistance of the base film and the coating layer are effectively improved.