203 results about "Double network" patented technology

The invention belongs to the technical field of biomedical materials, and particularly relates to preparation of a hydrogel ultrasonic coupling patch for long-term stable continuous monitoring. According to the patch, an interpenetrating double-network structure system is formed by an alginate component and a polyacrylic acid component through intermolecular interaction, and the patch has excellent adhesion performance and mechanical performance. Compared with the prior art, by optimizing the components and the preparation process, the obtained hydrogel patch has the following advantages that the excellent acoustic impedance matching characteristic is achieved, and high-fidelity transmission of ultrasonic signals is ensured; the tissue adhesion is strong, and long-term stable attachment can be realized; good mechanical stability and durability are achieved, and the method is suitable for continuous monitoring application. The product effectively solves the technical problems that the traditional liquid coupling agent is easy to lose, the solid coupling patch is insufficient in adhesion and the like, and has important application value in the fields of medical ultrasonic diagnosis and long-term monitoring.

The invention discloses preparation and application of dual-network hydrogel. The dual-network hydrogel comprises the following components: (Z1) a spinal cord acellular matrix network DSM formed by self-assembly of a spinal cord acellular matrix dSECM; and (Z2) a metal-polyphenol network MPN formed by coordination of metal ions and polyphenols; wherein the DSM and the MPN are cross-linked through hydrogen bonds to jointly form a double-network structure. DSM provides a microenvironment suitable for cell survival and growth for the dual-network hydrogel and induces stem cells to differentiate into neurons, and MPN provides the dual-network hydrogel with biological effects of inhibiting inflammation and accumulation of reactive oxygen species (ROS). The dual-network hydrogel has the advantages of the two components, the active component neurotrophic factor and the inhibitor loaded on the dual-network hydrogel can regulate and control immune response after SCI, improve neuroinflammation microenvironment and promote nerve repair, and a new strategy is provided for in-situ tissue repair of SCI.

The invention discloses silicone rubber and a preparation method thereof, and belongs to the technical field of silicone rubber, and the silicone rubber is prepared from the following raw materials: raw vinyl silicone rubber, zinc acrylate, a platinum catalyst, a hydrogen-containing silicone oil cross-linking agent and silicon carbide nanowires. According to the invention, a covalent network based on raw vinyl silicone rubber is constructed in the silicone rubber, and zinc acrylate and silicon carbide nanowires form an ionic network, so that the double-network structure not only can improve the technical problem of high probability of rubber overflow in the preparation process of the silicone rubber, but also can enable the silicone rubber to obtain better mechanical properties.

Cell engineering, soft robotics and wearable electronics often desire soft materials that are easy to deform, self-heal, and relax stress. Hydrogel, a type of hydrophilic networks, which can be made responsive to environmental stimuli, are often used in the aforementioned applications. However, conventional hydrogels often suffer from poor stretchability and repairability. Here, we report hydrogels consisting of boronic ester dynamic covalent bonds in a double network of poly(vinyl alcohol) together with chitosan, demonstrating extreme stretchability (up to 310 times of the original length), instant self-healing (within 5 sec), reusability as well as inherent adhesion. Their instant stress relaxation as a result of low activation energy of the boronic ester bond exchange (less than 20 KJ / mol) contributes to the extreme stretchability and self-healing behaviors. The hydrophilic environment readily incorporates various additives and provide opportunities in conductive soft materials, bio-signaling, and soft artificial joint.

The invention relates to a differentiated'inner core and outer sheath 'triboelectric stimulation bionic nerve graft and a preparation method thereof. The nerve graft is composed of an outer sheath layer and an inner core layer. Wherein an outer sheath layer is a calcium ion cross-linked waterborne polyurethane / sodium alginate double-network structure hollow conduit, and an inner core layer is oriented conductive polymer / silk fibroin nanofibers. The nerve graft provided by the invention is provided with the sheath part with an internal and external differential gradient hole structure and the bionic inner core similar to a natural nerve structure, when the nerve graft is implanted into a body, the inner core and the outer sheath show differential degradation speeds and hydrophilic-hydrophobic properties, and can generate electrical stimulation synchronously responding to physiological activities, so that regeneration after nerve injury is facilitated.

The invention relates to high-strength degradable self-healing hydrogel and a preparation method thereof, and belongs to the technical field of high polymer materials. The hydrogel is prepared from the following components in percentage by mass: 15 to 20 percent of carboxymethyl cellulose, 10 to 14 percent of acrylic acid, 15 to 20 percent of N-isopropylacrylamide, 4 to 8 percent of tannic acid, 2 to 4 percent of borax, 0.06 to 0.1 percent of laccase, 0.5 to 1 percent of N, N-methylene bisacrylamide, 0.4 to 0.6 percent of potassium persulfate and the balance of phosphate buffer solution. According to the hydrogel disclosed by the invention, through dual-network structure design, dynamic covalent bond crosslinking and enzyme catalysis green synthesis, collaborative optimization of high strength, high self-healing property, degradability and multi-responsiveness is realized, and the problems of poor mechanical property, low repairing efficiency, environmental unfriendliness and the like of traditional hydrogel are solved; the method has wide application potential in the fields of biomedicine, flexible electronics, intelligent packaging and the like.

The invention discloses a preparation method of an in-situ self-generated diaphragm type dual-network polymer electrolyte and a battery, and belongs to the technical field of lithium batteries. A staged in-situ polymerization strategy is adopted and comprises the following steps: firstly, applying a precursor solution containing an acrylate monomer, a polythiol cross-linking agent, a cyclic ether monomer, an initiator and a lithium salt to the surface of an electrode, partially polymerizing the solution under first initiation conditions such as transient ultraviolet irradiation and the like, and generating a layer of semi-solid gel diaphragm on the surface of the electrode in situ; then, an electrode with the gel diaphragm and a counter electrode are safely assembled into a battery; and finally, under second initiation conditions such as room temperature curing and the like, integrally curing and forming the dual-network polymer electrolyte in the battery. According to the method disclosed by the invention, physical isolation is realized by ingeniously utilizing the intermediate-state gel diaphragm, and the prepared electrolyte has high ionic conductivity, high mechanical strength and excellent interface stability, so that the assembled diaphragm-free solid-state lithium battery shows ultra-long cycle life.

The invention discloses a method for in-situ rapid growth of a dual-network hydrogel coating on the surface of a base material by a one-step method, which comprises the following steps: putting the base material with an adhesion initiation layer on the surface into a hydrogel precursor solution, and carrying out in-situ polymerization for 0.1-10 minutes under light irradiation, wherein the adhesion initiation layer comprises an adhesive compound based on a catechol group and a first photoinitiator, and the hydrogel precursor solution comprises a natural polymer containing tyrosine, an acrylic monomer, a cross-linking agent and a second photoinitiator, and wherein the first photoinitiator and the second photoinitiator are different from each other and are independently selected from a divalent ruthenium compound and a persulfate. Compared with the prior art, the natural / synthetic polymer double-network gel coating with biological activity and mechanical property can grow on the surfaces of different substrates more quickly and efficiently through a one-step method; and the base material, the surface of which is modified by the in-situ grown double-network hydrogel coating, obtained by the method can be applied to in-vivo medical apparatuses and instruments.

The invention provides multifunctional bionic hydrogel as well as preparation and application thereof in traumatic brain injury treatment, and belongs to the field of biomedical materials. The preparation method comprises the following steps: combining polydopamine modified hemoglobin nanoparticles with curcumin-based carbon quantum dots with anti-inflammatory activity, and embedding into bionic hyaluronic acid-collagen double-network hydrogel, so as to prepare the multifunctional bionic hydrogel. The hydrogel can effectively relieve neuron hypoxia, reduce apoptosis, promote the polarity of microglial cells to be converted into anti-inflammatory phenotype, and significantly down-regulate the expression of S100A8, thereby inhibiting pathological neural immune crosstalk. In a traumatic brain injury model, hydrogel implantation improves the pathological microenvironment, enhances endogenous nerve regeneration, and ultimately results in significant neurological function and cognitive recovery. The multifunctional bionic hydrogel prepared by the invention has a good application prospect in preparation of materials for preventing and / or treating traumatic brain injury.

The invention belongs to the technical field of nano materials and environment-friendly functional coatings, and discloses a preparation method and application of a lignin-based super-hydrophobic coating. The method comprises the steps that lignin is pretreated with ethylene carbonate to break steric hindrance and improve the grafting rate, then hexadecyl trimethoxy silane is added for grafting to form a hydrophobic chain, and surface energy is reduced; then adding silicon dioxide and N, N-dimethylformamide, carrying out ultrasonic dispersion to synergistically construct a micro-nano coarse structure, spraying the micro-nano coarse structure on a base material by using a spraying method, and putting the base material into a drying oven for curing, so as to obtain the lignin-based super-hydrophobic coating material. According to the method disclosed by the invention, a high-activity epoxy group is grafted on a lignin skeleton through ethylene carbonate pretreatment, so that steric hindrance in a three-dimensional space is broken, and dense anchor points are provided for a subsequent hydrophobic chain; then cocondensing with hexadecyl trimethoxy silane to form an alkyl-siloxane double network, and cooperating with nano silicon dioxide to construct micro-nano double roughness, so that a stable super-hydrophobic core under a fluorine-free condition is realized, and the technical route is simple and efficient.

The preparation method comprises the following steps: by taking an oriented polylactic acid nanofiber membrane as a raw material, carrying out homogenization treatment to obtain polylactic acid piezoelectric short fibers; gelMA is used as a skeleton matrix, polylactic acid short fibers, LAP and DRG cells are compounded, a 0 / 90-degree alternate grid structure scaffold is constructed through pneumatic extrusion type biological printing, and the dual-network piezoelectric biological scaffold is formed through blue light crosslinking curing. The piezoelectric effect of polylactic acid short fibers is activated through ultrasonic stimulation, mechanical energy is converted into local electric signals, loaded DRG cells are directly driven to secrete CGRP in situ, macrophages are dynamically regulated and controlled to be polarized to M2 anti-inflammatory phenotypes, nerve-immune microenvironment disorder of diabetic bone defects is corrected, vascularization and bone regeneration are promoted, and the diabetic bone defect treatment effect is improved. The problems of short delivery half-life period of traditional cell factors, difficulty in nerve function reconstruction and chronic inflammation caused by non-degradable piezoelectric materials are solved, and non-invasive and degradable precise bone repair is realized.

This invention discloses a composite hydrogel based on a polysaccharide-based hybrid dual network, its preparation method, and its applications, belonging to the field of marine polysaccharide technology. Based on the important role of amorphous calcium phosphate, a precursor in biomineral formation, in mineralization, this invention prepares a multifunctional composite hydrogel with wet bonding, antibacterial, and remineralization functions. This composite hydrogel can achieve rapid and convenient repair of enamel demineralization. This invention prepares oxidized sodium alginate via an alcohol-aqueous phase using the sodium periodate method. Sodium alginate reacts with carboxymethyl chitosan and dopamine through a Schiff base reaction to form dynamic imine bonds, thus preparing an in-situ self-crosslinking hydrogel. Simultaneously, amorphous calcium phosphate is introduced for secondary crosslinking, preparing a dense dual-network composite hydrogel. The composite hydrogel prepared by this invention has an interconnected three-dimensional porous structure, stable mechanical properties, and uniformly dispersed amorphous calcium phosphate in the form of nanospheres. The composite hydrogel prepared by this invention provides an integrated strategy with clinical translational potential for orthodontic enamel demineralization, with broad market prospects.

The present application relates to the technical field of hydrogel, in particular to an injectable temperature-responsive enhanced composite double-network magnetic particle gel, a preparation method and application thereof, the hydrogel is composed of a particle gel network formed by gelatin nanoparticles and Fe3O4 nanoparticles through electrostatic interaction and a poly-N-isopropyl acrylamide (PNIPAM) based temperature-sensitive polymer gel network. At room temperature, the hydrogel has excellent shear thinning and self-healing properties, and can be easily injected through a needle and a microcatheter. When the temperature rises to human body temperature (37 DEG C), the temperature-sensitive polymer phase transition crosslinking enhances the mechanical properties of the gel network. The hydrogel is injectable in vitro, temperature-responsive in vivo, meets the requirements of vascular interventional embolization materials, and can be magnetically heated under an alternating magnetic field, and is used for liver cancer embolization combined with magnetic heating treatment. The preparation method is simple, has high biocompatibility, and has great clinical application potential.

The invention relates to the technical field of composite films, and particularly discloses a high-fastness colored high-brightness composite film packaging material manufacturing process which comprises the steps of S1, base film preparation and pretreatment, S2, surface activation treatment, S3, colored coating preparation, S4, coating, S5, gradient drying and curing and S6, curing. Through corona and twice plasma treatment of different gases, oxygen-containing, amino and fluorine-containing groups are synergistically introduced to the surface of a base membrane, the chemical bonding and hydrogen bonding effects of a coating and the base membrane are enhanced, a composite system of epoxy resin, hydroxy acrylic resin and polyurea resin is adopted, and modified carbon black with the aminated surface is matched, so that the coating has a good anti-corrosion effect on the surface of the base membrane. Under the action of a catalyst and a cross-linking agent, a compact chemical cross-linking and hydrogen bond physical cross-linking dual-network structure is formed; and gradient heating drying and low-temperature curing processes are combined, so that stable volatilization of the solvent and full and complete cross-linking reaction are ensured, and the adhesive force and wear resistance of the base film and the coating layer are effectively improved.

The invention discloses a carbon fiber polyester composite felt and a preparation method thereof, and relates to the technical field of high polymer materials, and the preparation method comprises the following steps: (1) carbon fiber directional activation; (2) in-situ grafting of sheath-core monofilaments; (3) dual-network synchronous lapping; and (4) node in-situ thermal consolidation. According to the preparation method disclosed by the invention, a carbon fiber polyester composite felt preparation system without an additional binder is constructed by sequentially implementing four steps of processes of carbon fiber directional activation, skin-core monofilament in-situ grafting, dual-network synchronous lapping and node in-situ thermal consolidation, and molecular-level synergistic combination of carbon fibers and polyester components is realized. The interface bonding strength and structural integrity of the composite felt can be remarkably improved, and meanwhile, the mechanical bearing stability of the composite felt is improved, so that the problems that in the prior art, carbon fibers and a polyester matrix are poor in interface compatibility, layering and falling are prone to occurring, and the service life is short can be solved. And the problems that the mechanical property of the composite felt is reduced, the preparation process is complicated and the environmental protection property is insufficient due to the need of adding an external binder are solved.

The present application relates to the technical field of oil exploitation, in particular to a profile control water plugging agent, a preparation method and application thereof. The method comprises the following steps: (1) mixing a cellulose compound, acrylamide and water, then adding a crosslinking agent, and then adding an initiator to perform a polymerization reaction; (2) mixing the material obtained in the step (1) with a metal salt solution, and then performing solid-liquid separation and drying; wherein the cellulose compound is selected from one or more than two of carboxymethyl cellulose, carboxyethyl cellulose and polyanionic cellulose. The profile control water plugging agent is a hydrogel material with a unique double network structure, and has good stability and still maintains good strength under high temperature and high salt conditions.

The application provides a poly(dimethyl diphenyl imide) siloxane / phenolic based double network hybrid resin and a preparation method and application thereof, and belongs to the field of advanced material technology. The application firstly provides a copolymer for preparing an ablative thermal protection hybrid resin, and the structure of the copolymer is shown as formula I. Then, the hybrid resin prepared from the copolymer is provided. The copolymer shown as formula I and the phenolic resin in the hybrid resin of the application have good compatibility, and the copolymer is uniformly distributed in the phenolic resin; and the hybrid resin is graphitized and ceramized in the ablative process, and has excellent ablative resistance. The application provides a new idea and method for preparing a new ablative resistant hybrid phenolic resin through copolymerization, and a new ablative resistant hybrid resin which is expected to meet the increasingly severe flight environment in the future is prepared.

The invention provides a preparation method of algae-based pure plain leather based on a dual-network gel system. According to the method, natural polysaccharide sodium alginate extracted from seaweed and xanthan gum obtained through microbial fermentation are used as raw materials, and a cross-linking reaction of the raw materials is accurately regulated and controlled to form a double-network structure formed by cross-linked alginate serving as a rigid network and a flexible xanthan gum hydrogen bond network; and the material is reinforced and toughened by utilizing the synergistic complementary characteristics of the two, and the size and deformation stability are kept. Meanwhile, the leather tanning fat liquoring principle is used for reference, and natural grease is introduced, so that the softness and durability of the material are effectively improved. According to the method, natural and renewable polysaccharide resources are adopted, animal components are not contained, and animal ethical problems and use of harmful chemicals are avoided. The method has the advantages of simple process, abundant raw materials, low cost, excellent mechanical properties of pure plain leather products, short production period, large-scale industrial production and wide market prospect, and particularly has the potential of becoming a green and environment-friendly substitute material in the fields of fashion and furniture.

Four-arm polyethylene glycol amine and preparation method and application thereof, relate to the technical field of high polymer materials, and solve the problem of poor comprehensive performance such as strength, fatigue resistance and swelling resistance when the traditional double network hydrogel is applied to the preparation of cartilage repair materials in the prior art. The four-arm polyethylene glycol amine provided by the application has a molecular weight of 10 kDa or 40 kDa. Four-arm polyethylene glycol, phthalimide, diisopropyl azodicarboxylate and triphenylphosphine are subjected to Mitsunobu reaction and hydrazinolysis to obtain four-arm polyethylene glycol amine with a molecular weight of 10 kDa. Four-arm polyethylene glycol, phthalimide, diisopropyl azodicarboxylate and triphenylphosphine are subjected to Mitsunobu reaction and hydrazinolysis to obtain four-arm polyethylene glycol amine with a molecular weight of 40 kDa. The double network hydrogel prepared from the four-arm polyethylene glycol amine has excellent comprehensive performance such as high mechanical strength, fatigue resistance, self-recovery and swelling resistance, and can be applied to the preparation of cartilage-like materials.

The application discloses a preparation method and application of a sodium alginate-cyperus esculeus protein / isolated whey protein double-network gel, and comprises the following steps: step 1, mixing cyperus esculeus protein, isolated whey protein and sodium alginate to prepare a compound; and step 2, adding gluconic acid-delta-lactone and calcium carbonate into the compound to promote gel formation, so as to obtain a sodium alginate-cyperus esculeus protein / isolated whey protein compound gel induced by calcium acetate coordination. Compared with a pure protein gel, the sodium alginate-cyperus esculeus protein / isolated whey protein compound gel has excellent performances in texture characteristics, rheological characteristics and the like, and the water retention of the compound gel is also better than that of the pure protein gel. Moreover, the double network has a good encapsulation rate for curcumin and has a good slow-release effect.

This invention provides a wide-temperature-range, long-life flexible zinc-lithium hybrid ion battery hydrogel electrolyte, its preparation method, and its application. The hydrogel electrolyte comprises a polymeric hydrogel framework and an electrolyte phase adsorbed and filled within the framework. The polymeric hydrogel framework is an interpenetrating double network structure formed by sodium alginate and polyacrylamide. The electrolyte phase comprises a mixed solvent, an electrolyte salt, and functional additives. The mixed solvent consists of water and a co-solvent. The electrolyte salt is zinc trifluoromethanesulfonate and lithium trifluoromethanesulfonate. The functional additives are alkali metal salts or rare earth metal salts. This invention, through the synergistic design of a zinc-lithium dual-salt system, an organic co-solvent, and trace amounts of rare earth functional additives, simultaneously achieves low-temperature antifreeze, dendrite suppression, and side reaction suppression in a zinc-lithium hybrid ion battery, thereby significantly improving the battery's wide-temperature-range cycle life and other electrochemical performance.

The application discloses an ultra-high molecular weight polyethylene non-woven fabric modified based on liquid metal and MXene and a preparation method thereof, and belongs to the technical field of protective functional textile composite materials. After the ultra-high molecular weight polyethylene non-woven fabric is pretreated through hydrophilic modification, a composite coating material composed of magnetic liquid metal formed by iron powder and liquid metal gallium and MXene is sprayed, then the liquid metal is spread between fibers and bridges MXene and iron powder through rolling treatment, a continuous conductive / magnetic double network is formed, a packaging layer is coated at last, and the ultra-high molecular weight polyethylene non-woven fabric modified based on liquid metal and MXene is obtained. The finishing process of spraying combined with rolling is simple, low in cost and easy to be industrialized; the prepared ultra-high molecular weight polyethylene non-woven fabric modified based on liquid metal and MXene has an electromagnetic shielding efficiency greater than 35 dB in the X wave band, meanwhile, excellent characteristics such as flexibility and wear resistance are maintained, and the unification of light weight and high performance is realized.

The invention discloses a method for preparing silk fibroin and hyaluronic acid composite gel, which comprises the following steps of: uniformly mixing hyaluronate with a first solvent to prepare hyaluronic acid gel, mixing the hyaluronic acid gel with a silk fibroin solution, shearing at a high speed, homogenizing and emulsifying, standing, shearing at a high speed, homogenizing and emulsifying, sealing and sterilizing to obtain the silk fibroin and hyaluronic acid composite gel. According to the method disclosed by the invention, reagents such as a cross-linking agent, an initiator and enzyme do not need to be additionally added; the silk fibroin solution and the hyaluronic acid gel can form uniform and mutually-crosslinked double networks in the homogeneous gel forming process, the phase separation risk is low, and the silk fibroin can generate an emulsion reaction through high-speed homogenization, so that the color of the composite gel is whiter; the preparation method disclosed by the invention is simple, rapid in emulsification and gel forming, short in production cycle, low in endotoxin of the product, high in biocompatibility, slow in degradation, small in inflammatory response and high in injection filling safety, and the composite gel can play a role in moisturizing and moisturizing after subcutaneous injection and has the whitening effects of improving skin elasticity and glossiness, fading fine wrinkles and the like.

The invention discloses an amide-imine dual-network polymer film, a preparation method and an application of the amide-imine dual-network polymer film in H2 / CO2 separation in a high-temperature and high-pressure system. The amide-imine dual-network polymer film coexisting in a crystalline state and an amorphous state is characterized in that crystal polymer structures with same or similar molecular structures exist in an amide-imine connected amorphous polymer film matrix; soaking the support body in an aqueous solution of m-phenylenediamine, taking out the support body, and standing until no obvious liquid drop exists on the surface of the support body; and then soaking in an organic solution of 1, 3, 5-benzoyl chloride and 1, 3, 5-benzenetricarboxaldehyde, and carrying out polymerization reaction on the surface of the support body to obtain the double-network polymer membrane. The polymer membrane shows excellent H2 / CO2 separation performance in a high-temperature and high-pressure system; the method is simple to operate and short in preparation period; the catalyst has high gas permeability, high selectivity and good stability at high temperature and high pressure, is easy for large-scale preparation, and has practical industrial application potential.

The invention discloses a flexible ionic thermal battery and a preparation method thereof, the flexible ionic thermal battery comprises an ionic gel electrolyte and asymmetric electrodes, and the asymmetric electrodes are an activated carbon fiber cloth cathode and a polyaniline anode; the activated carbon fiber cloth cathode is obtained by activating carbon fiber cloth with a mixed solution of concentrated nitric acid and concentrated sulfuric acid; the ionic gel electrolyte is obtained by soaking acrylamide and acryloyloxyethyl trimethyl ammonium chloride dual-network gel in an electrolyte solution of FeCl3 / HCl. According to the flexible ionic thermal battery disclosed by the invention, a built-in potential field is constructed under a near-isothermal condition through electrode-electrolyte interface reaction characteristic difference, and decoupling of dependency of the potential field and a temperature field in a traditional quasi-solid-state ionic thermal battery is realized, so that the ionic thermal battery can finish thermal charging through near-isothermal temperature rise in an ultrathin form within 1mm, and the flexible ionic thermal battery has a wide application prospect. And stable discharge output is realized in a constant-temperature stage.

The invention discloses a preparation method of a self-crosslinking injectable dual-network OXG-CS-Gel composite hydrogel, which comprises the following steps: dissolving oxidized xanthan gum in ultrapure water to obtain an oxidized xanthan gum solution, dissolving gelatin in ultrapure water to obtain a gelatin solution, dissolving chitosan in an acetic acid solution, stirring at room temperature until complete dissolution to obtain a chitosan solution, and carrying out freeze drying to obtain the self-crosslinking injectable dual-network OXG-CS-Gel composite hydrogel. The preparation method comprises the following steps: adding a chitosan solution into an oxidized xanthan gum solution, uniformly stirring to obtain an OXG-CS solution, then adding a gelatin solution, uniformly stirring to obtain an OXG-CS-Gel solution, and standing to form gel to obtain OXG-CS-Gel composite hydrogel; the composite hydrogel obtained by the invention is formed by a dynamic Schiff base bond and a hydrogen bond, has excellent self-crosslinking capability, self-healing performance, injectable performance and swelling performance, overcomes the defects that the traditional hydrogel is complex in gelling process, needs a cross-linking agent for cross-linking and the like; and a new material is provided for the fields of minimally invasive injection, wound healing, hemostatic materials, targeted drug delivery and the like.

The invention belongs to the technical field of biological medicine, and particularly discloses a sprayable double-network hydrogel microsphere adhesive and a preparation method and application thereof.The preparation method comprises the following steps that liquid paraffin, sorbitan monooleate and polyoxyethylene sorbitan monolaurate serve as oil phases, and an emulsion is formed; fully mixing the emulsion with petroleum ether, centrifugally separating gel microspheres, freeze-drying, and storing in a dark place; preparing a ropivacaine liposome; and adding ultrapure water into the lipid membrane to obtain a primary liposome suspension, adsorbing the liposome by using the hydrogel microspheres, and collecting the obtained dual-network hydrogel microspheres. According to the sprayable double-network hydrogel microsphere adhesive as well as the preparation method and the application thereof, prepared hydrogel microspheres can quickly and consistently cover irregular wounds, and liposome loaded with ropivacaine provides continuous analgesic release, so that the painful wound healing effect is improved. By simultaneously solving the problems of maintaining continuous adhesion and prolonging pain relief in blood-saturated wounds.

The application discloses a semi-interpenetrating double network organic gel OCA optical adhesive applied to a folding display device and a preparation method and a folding display device thereof. The preparation method is as follows: after a crosslinking network component, a non-crosslinking network component and a polar small molecule are uniformly mixed, the mixture is coated on a release film and is placed into an oven for drying. The OCA optical adhesive has the crosslinking network component as a skeleton in the colloid, the cohesive energy is enhanced, and the creep resistance is enhanced; the non-crosslinking network component improves the wettability of the colloid, and the peeling strength of the optical adhesive is improved; and the polar small molecule enhances the energy dissipation of the colloid, is favorable to the stress generated during bending, and further enhances the flexibility of the colloid. The OCA optical adhesive has a light transmittance greater than 99%, a haze value not more than 0.1%, excellent optical performance, moderate initial adhesion and peeling force, and a continuous bending resistance of more than 200,000 times, and can be widely applied to the device bonding of the folding display device.

The application discloses a polyvinyl alcohol film and a preparation method and application thereof. The material of the polyvinyl alcohol film comprises a main material and an auxiliary material. The main material is polyvinyl alcohol, and the auxiliary material is a water-soluble high polymer material. The average polymerization degree of the water-soluble high polymer material is 2-10 times of the average polymerization degree of the polyvinyl alcohol. The polyvinyl alcohol film is modified by forming a high polymer double network. The water-soluble high polymer material with a high polymerization degree, whose average polymerization degree is 2-10 times of the average polymerization degree of the polyvinyl alcohol, is added into the polyvinyl alcohol, so that a high polymer double network structure with the polyvinyl alcohol as the main body is obtained. The tensile property of the polyvinyl alcohol film is greatly improved, and the thinness of a polarizing film with the polyvinyl alcohol film as an optical base film and the optical property of the polarizing film are improved.