1249 results about "Wound dressing" patented technology

The invention belongs to the technical field of metal organic frameworks, and particularly relates to a high-performance photocatalytic metal organic framework antibacterial material as well as a preparation method and application thereof. The preparation method comprises the following steps of: growing a metal organic framework UiO 66 which takes a cerium element as a metal node on a single-layer graphene oxide UiO66 (at) GO in situ, loading arginine small molecules in the MOF framework to obtain a high-performance photocatalytic MOF antibacterial material UiO66 (at) GO (at) arg, forming a nano hydrogel with a stable three-dimensional structure with chitosan, and performing antibacterial treatment by using the nano hydrogel as a wound dressing. The Ce-based MOF composite QCS / GO-UiO 66-coated arg / PNIPAm hydrogel prepared by the preparation method disclosed by the invention has excellent properties such as elasticity, adhesive power, water absorption and biocompatibility; and under illumination, the photocatalyst has an excellent photocatalytic sterilization effect, and has a good killing effect on escherichia coli and staphylococcus aureus.

The invention relates to the technical field of material physical property detection, and discloses an injectable hydrogel wound dressing water absorbability detection method, which comprises: constructing a main measurement and reference dual channel, and synchronously monitoring a mixed conductivity signal and an interference signal generated only by gel self ion leakage; according to the method, the interference is deducted through real-time differential operation, a pure target signal is obtained, and then the water absorption volume of the hydrogel is calculated through inversion based on the law of conservation of mass, a measured object is transferred to an external solution from a gel body, and the interference of a sample is stripped through an endogenous dynamic correction mechanism, so that the accuracy of the water absorption volume of the hydrogel is improved. The determinacy of a measurement result is derived from a physical law instead of model hypothesis, so that double restrictions caused by irregular sample forms and complexity of a chemical environment are avoided, and reliable quantification of the water absorption performance of the in-situ dynamic forming hydrogel is realized.

The invention belongs to the technical field of medical dressings for repairing skin injury wounds, and provides a nanofiber wound dressing with a photo-thermal chemical synergistic antibacterial effect and a preparation method. A PVA / CS solution composed of polyvinyl alcohol PVA and chitosan CS is used as an electrospinning matrix, branched polyethyleneimine BPEI modified graphene oxide GO nanoparticles GO-BPEI are added to serve as a photo-thermal antibacterial component, lanthanum chloride is added to serve as a chemical antibacterial component, an electrostatic spinning solution is prepared, the electrostatic spinning solution is subjected to electrostatic spinning, and the PVA / CS / GO-BPEI / La nanofiber wound dressing is obtained. The obtained fiber surface has a good three-dimensional structure, shows obvious chemical antibacterial ability, can be subjected to photothermal conversion under near-infrared light illumination, can achieve the purpose of photothermal bacteriostasis, further improves the antibacterial property, and has good mechanical property, air permeability, water absorption and biocompatibility at the same time.

The invention discloses a hydrogel wound dressing for promoting healing of infectious wounds. The hydrogel wound dressing is prepared from the following raw materials: oxidized methacrylic acid hyaluronic acid, waterborne polyurethane, polylysine, cannabidiol, neomycin sulfate and 2-roots alcohol. The invention also provides a preparation method of the hydrogel wound dressing and application of the hydrogel wound dressing in preparation of products for repairing infectious wounds. The wound dressing provided by the invention has a microporous structure, good biocompatibility and biodegradability, and can be used for stopping bleeding, reducing wound infection and promoting cell proliferation and wound healing.

The invention discloses a Janus wound dressing with antibacterial and tissue repair promoting functions and a preparation method of the Janus wound dressing, belongs to the technical field of wound dressings, and aims to realize antibacterial, tissue repair promoting and moist wound healing microenvironment through freeze drying and electrostatic spinning technologies. Polycaprolactone (PCL), bioactive glass (BG) and curcumin Cur are used for preparing a hydrophobic inner layer capable of promoting tissue repair, methacrylated gelatin GelMA is used for preparing a hydrophilic outer layer with moisturizing performance, and the PCL-BG-Cur / GelMA composite wound dressing with antibacterial, moisturizing and repair promoting functions is constructed. Animal experiment results show that the dressing loaded with curcumin Cur and bioactive glass BG has multiple functions of synergistic antibiosis, moisturizing and the like, the result shows that the prepared dressing has the performance of promoting epithelization, collagen deposition, new hair follicle formation and the like, and the dressing has a considerable application prospect in the aspect of rapid wound repair.

The present invention relates to an electrospun fiber, a process for preparing the same, a nonwoven fabric comprising the electrospun fiber, as well as corresponding uses and articles. The inventive electrospun fiber comprises a polymer, a surface-reacted calcium carbonate and a pharmaceutically or nutraceutically active ingredient, wherein at least a part of the pharmaceutically or nutraceutically active ingredient is present within the pores of the surface-reacted calcium carbonate. The inventive fibers may be used e.g. in yarns, transdermal patches, intrabuccal patches, implantable textiles, wound dressings and / or medical tapes.

Embodiments of negative pressure wound therapy systems and methods for operating the systems are disclosed. In some embodiments, a system includes a pump assembly, canister, and a wound dressing configured to be positioned over a wound. The pump assembly, canister, and the wound dressing can be fluidically connected to facilitate delivery of negative pressure to a wound. The system can additionally include a valve configured to control the introduction of positive pressure to the wound.

The invention belongs to the technical field of biomedical materials, and particularly relates to a hydrogel wound dressing and a preparation method and application thereof. The hydrogel wound dressing disclosed by the invention can be matched with a sound-sensitive agent by utilizing the temperature-sensitive shrinkage performance of the temperature-sensitive compound monomer, and shows ultrasonic thermal response shrinkage performance, specifically, the hydrogel wound dressing can be rapidly heated and remarkably shrunk under the ultrasonic action to promote wound shrinkage, so that wound healing is accelerated. The obvious potential is embodied in the aspects of promoting the repair of the wound infected by the drug-resistant bacteria and the repair of the wound infected by the drug-resistant bacteria and diabetes mellitus. When the prepared hydrogel wound dressing is used, the contraction degree of the hydrogel wound dressing can be controlled by adjusting the ultrasonic time in the treatment process, and protection and treatment effects on drug-resistant bacteria wounds are achieved in a programmed mode. Meanwhile, the fixing structure of the hydrogel can anchor added drugs such as a sound-sensitive agent and the like, and the action time of the drugs is prolonged.

The invention belongs to the field of high polymer material chemistry, and particularly relates to double-network hydrogel based on sodium alginate / gelatin, a preparation method and dressing. A chemical method of grafting modification is adopted, grafting modification is carried out by designing abundant active groups on side chains of gelatin and sodium alginate, and based on traditional gelatin or sodium alginate hydrogel, not only is the thermal stability of gelatin improved, but also the biological activity of sodium alginate is improved, and the antibacterial property is achieved; the finally prepared SD / GelMA dual-network hydrogel wound dressing not only has excellent mechanical properties, but also has very high biocompatibility and antibacterial activity, and has huge application prospects and potential in the aspect of skin wound healing.

The invention relates to a liquid metal dual-network hydrogel patch with intelligent adhesion as well as a preparation method and application thereof, and belongs to the field of bioelectric sensing materials. By utilizing the characteristic that a polymer chain in the hydrogel has temperature-dependent phase change, the hydrogel is endowed with the advantages of intelligent adhesion and on-demand removal without pain and stimulation, and meanwhile, the hydrogel has good mechanical strength, is low in cost and convenient to operate, is suitable for large-scale production, popularization and application, and has wide application prospects. Wide application values are realized in the fields of wound dressings, postoperative care and the like.

The invention discloses a method for preparing a methylacryloyl chitosan / gelatin-based hydrogel wound dressing through 3D printing and application, and relates to a method for preparing a hydrogel wound dressing and application. The problems that existing MXene is high in photo-thermal conversion temperature, and bacteria rapidly breed again after near-infrared irradiation is closed are solved. The ZGC composite hydrogel wound dressing integrates multiple functions, can simultaneously realize hemostasis, antibiosis, anti-inflammation, vascularization promotion and cell regeneration, and is especially suitable for infectious wounds. The antibacterial performance can be achieved under the activation of near-infrared light through the dual effects of a photothermal therapy and a photodynamic therapy, and meanwhile, the antibacterial effect can be achieved in cooperation with Zn < 2 + >. The ZGC composite hydrogel wound dressing can be accurately customized and printed through a 3D printing technology according to the shape and depth of a wound, the composite dressing can achieve accurate low-temperature photo-thermal treatment, meanwhile, the continuous release of Zn < 2 + > and the physical antibacterial function of MXene are maintained, normal tissue is protected while bacteria are killed, and the healing rate of an infected wound is remarkably increased.

The present invention provides a dressing capable of promoting healing of a chronic wound. Specifically, provided is a multifunctional wound dressing, comprising: first active components: β-nicotinamide mononucleotide (NMN), nicotinamide adenine dinucleotide (NAD+), or a combination thereof; and a dressing matrix. Experiments of the present invention prove that the multifunctional wound dressing of the present invention has an excellent effect of promoting healing of chronic refractory wounds such as diabetic feet.

A medical device for dressing head wounds of a patient. The device has a dome-shaped flexible cap with a circumferential pocket around its base and an adjustable strap having two opposite ends, wherein the two opposite ends can be affixed to the flexible cap using an attachment mechanism. The adjustable strap is further adapted to cover the patient's chin, thereby securing the flexible cap over the patient's head. The adjustable strap can further have a chin pocket at a middle portion of the strap such that it overlays the patient's chin. The circumferential pocket and the chin pocket are configured to accommodate at least one wound dressing pad for covering the head wounds, wherein the head wounds are located at least partially in front, back, and / or below the patient's ears and at least partially on the patient's chin.

According to the method, a one-pot copolymerization method is adopted, MBAA and borax serve as cross-linking agents, zwitterionic polyelectrolyte hydrogel containing SBMA, PVA, THMA and AMPS is prepared, and the zwitterionic polyelectrolyte hydrogel has excellent adhesion performance and biocompatibility and is suitable for the field of biological medicine. According to the method, the physical characteristics of the hydrogel are enhanced due to crosslinking sites and hydrogen bonds of polyvinyl alcohol. The cationic and anionic groups of SBMA improve the adhesion performance, and the reaction monomer THMA provides hydrogen-bond interaction to further promote adhesion, so that the prepared hydrogel adhesive shows excellent adhesion performance and biocompatibility, and is suitable for biological medicine application of wound dressing, drug release systems, tissue engineering and the like.

Disclosed herein are embodiments of a wound treatment apparatus with electronic components integrated within a wound dressing. In some embodiments, a wound dressing apparatus can comprise a wound dressing. The wound dressing can comprise an absorbent material, an electronics unit comprising a negative pressure source, the electronics unit integrated within the wound dressing and at least partially encapsulated by a flexible film. The flexible film can comprise a window or aperture configured to permit fluid communication between the absorbent material and the negative pressure source. In some embodiments, a wound dressing apparatus can comprise a wound contact layer, an absorbent layer over the wound contact layer, the absorbent layer comprising one or more apertures, a cover layer configured to cover and form a seal over the wound contact layer and the absorbent layer, and an electronics assembly comprising a negative pressure source. A portion of the cover layer overlying the one or more apertures in the absorbent layer can be configured to be compressed within the aperture in the absorbent layer when negative pressure is applied to the wound dressing apparatus. The compressed cover layer can indicate a level of negative pressure below the cover layer. In some embodiments, the wound dressing apparatus can comprise an indicator material layer and a cover layer configured to cover and form a seal over the wound contact layer and the indicator material layer. The indicator material layer can be configured to protrude relative to a surrounding surface of an upper surface of the wound dressing apparatus when negative pressure is applied to the wound dressing apparatus and the protruding indicator material layer indicates a level of negative pressure below the cover layer.

The invention belongs to the technical field of medical and mechanical combinations, and discloses a high-permeability and low-sensitivity ripdicaine wound patch and a preparation method thereof.The high-permeability and low-sensitivity ripdicaine wound patch comprises a wound patch body, and the wound patch body is prepared from, by mass, 0.1%-0.4% of sodium hyaluronate, 1.5%-3.5% of lidocaine, 1.5%-3.5% of prilocaine, 3%-10% of solvent, 0.5%-8% of emulsifier, 2%-10% of humectant, 0.1%-5% of soothing agent, 0.1%-1.5% of stabilizer, 0.1%-1% of thickener and the balance water. According to the present invention, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, and the total amount of the raw materials is 100%. And the anesthetic has the advantages of quick effect taking, low sensitivity, capability of resisting moist heat sterilization and good stability.

The invention discloses a hydrogel wound dressing with a synergistic healing promoting function as well as a preparation method and application thereof. The preparation method comprises the following steps: 1, dissolving oxidized methacrylated hyaluronic acid and dopamine in deionized water to obtain a solution A; the preparation method comprises the following steps: dissolving N-isopropylacrylamide, a photoinitiator 2-hydroxy-2-methyl-1-(4-(2-hydroxyethoxy) phenyl)-1-acetone and a cross-linking agent N, N '-methylene bisacrylamide in deionized water to obtain a solution B; 2, mixing the solution A and the solution B to obtain a pre-gel solution; or dissolving polyphenylboronic acid ester nanoparticles or polyphenylboronic acid ester-kaempferol with deionized water to obtain a solution C, and mixing the solution C with the solution A and the solution B to obtain a pre-gel solution; and 3, injecting the pre-gel liquid into a mold, and illuminating to obtain the hydrogel wound dressing loaded with the nanoparticles. The hydrogel disclosed by the invention can be used for effectively solving various problems in a wound healing process and promoting rapid and high-quality healing of a wound.

The invention relates to the technical field of material physical property testing, and discloses an injectable hydrogel wound dressing tensile strength testing method, which comprises: establishing a correlation model of the mass and the maximum fracture load of a standard sample at different temperatures, and the correlation model of the initial rigidity and the temperature; measuring the mass and the actual maximum fracture load of the to-be-measured sample, and determining the actual initial rigidity of the to-be-measured sample; according to the method, the actual initial stiffness is calculated, the equivalent temperature of the test is converted by utilizing the actual initial stiffness, the standard theoretical maximum fracture load is calculated in combination with the sample mass and the corresponding model, and the performance is judged by comparing the two, so that the measurement of the geometric dimension of an irregular sample is avoided by constructing the correlation between the mass and the mechanical performance; the quality control problem of an in-situ forming material is solved, and the reliability of a judgment result in an industrial environment is further ensured by utilizing mechanical response data of the same test through an integrated temperature self-adaptive calibration mechanism.

Disclosed herein is a thermogalvanic cell material suitable for use in a wound dressing, comprising: a biocompatible hydrophobic polymeric material; and a biocompatible ionically- crosslinked hydrogel material, wherein: the biocompatible polymeric material is provided in the form of a non-woven three-dimensional network formed from nanofibers having a first surface, a second surface and a middle portion therebetween; the biocompatible ionically- crosslinked hydrogel material is located in the middle portion of the three-dimensional network, such that the ionically-crosslinked hydrogel material encapsulates at least part of the nanofibers in the middle portion of the non-woven three-dimensional network; and the ionically-crosslinked hydrogel material is crosslinked by at least two multivalent metal ions that form a redox couple. Also disclosed herein are a device suitable for use as a wound dressing, a wound dressing, and a method of making the thermogalvanic cell material.

The present invention relates to a wound dressing comprising a polymeric support having a coating of a polymer network comprising a poly-(4-styrenesulfonic acid-co-maleic acid) (PSS-MA) component covalently bonded to at least one of an uncharged polymer component and a non-polymeric crosslinker component thereby forming the polymer network, wherein the PSS-MA component comprises sulfonate groups, and a method to prepare it.

The invention discloses a negative pressure coupled electric field wound dressing, comprising a dressing body, the top of which is covered with a flexible sealing film for sealing and fixing the dressing body on the wound surface, a negative pressure component connected with the dressing body and generating negative pressure is arranged on the flexible sealing film, an electrode ring for applying to the wound surface to generate an electric field is arranged on the dressing body, a pyroelectric element for sensing the temperature change of the wound surface to release the charge is embedded in the dressing body, and the pyroelectric element is connected to the electrode ring. It has the advantages of simple structure and avoiding electric field failure caused by twisting and breaking of the wire.

The present invention concerns extensible absorbent pads for wound dressings. The absorbent pad has a plurality of fenestrations therein, wherein the fenestrations are arranged in a pattern about a central point. The pattern comprises one or more fenestrations having symmetry about a cardinal axis and one or more fenestrations having symmetry about an intercardinal axis, wherein the cardinal and intercardinal axes cross at the central point. The absorbent pads of the present invention can be used in advanced wound care dressing applications where additional stretch and extensibility of the dressing will assist clinicians in applying the dressing to difficult to dress anatomical areas.

The invention discloses a bone joint wound dressing fixator, relates to the technical field of medical instruments, and particularly aims to solve the problems that in the prior art, when an existing joint dressing is used, due to the fact that the joint of a patient does rehabilitation exercise, the dressing rubs against the wound of the patient, the wound of the patient is hurt, and the patient feels uncomfortable. In order to solve the problem that the dressing cannot be tightly attached to the wound all the time on the basis that rehabilitation exercise is not affected, the bone joint wound dressing fixator comprises an elastic fixing band, a knee protection sleeve, a synchronous moving mechanism, an air conveying mechanism, an air ring and a self-adaption mechanism. The dressing and the wound of the patient are always kept in an attached state in the movement process of the patient, friction between the dressing and the wound is greatly relieved, and cooling, ventilating and drying operation is conducted on the wound at the same time.

The invention belongs to the technical field of medical materials, and particularly relates to a degradable wound dressing and a preparation method thereof. Compared with the prior art, the degradable wound dressing prepared by the preparation method disclosed by the invention is a completely biodegradable Janus composite film, and a hydrophobic inner layer and a hydrophilic outer layer are obtained by selecting different materials; the material PGA with excellent biological performance is utilized, the problem that electrostatic spinning cannot be carried out through pure PGA is solved, PGA and gelatin are creatively mixed, the advantages of PGA and gelatin are combined, and the PGA / Gel electrostatic spinning film which is high in toughness, high in tensile strength, good in biocompatibility and high in medicine carrying efficiency is obtained; meanwhile, the functions of resisting bacteria, resisting inflammation, discharging seepage and promoting angiogenesis are achieved, and the wound healing rate is effectively guaranteed.

The invention provides a wound dressing for diminishing inflammation, easing pain and promoting wound healing and a preparation method thereof. The wound dressing capable of diminishing inflammation, easing pain and promoting wound healing is prepared from the following components in parts by mass: 6 to 10 parts of oxidized sodium alginate, 7 to 9 parts of hydrazide gelatin, 1 to 1.5 parts of tannic acid, 8 to 12 parts of polyethylene glycol, 0.05 to 0.1 part of cannabidiol, 0.05 to 0.1 part of neomycin sulfate, 0.2 to 0.3 part of 2-roots alcohol, 0.02 to 0.04 part of vitamin C palmitate and 0.03 to 0.1 part of epsilon-polylysine. The dressing can achieve excellent effects of diminishing inflammation, easing pain and promoting wound healing through synergistic cooperation of all the components.

The invention discloses a COF electrostatic spinning wound dressing with near-infrared response and antioxidant activity and a preparation method of the COF electrostatic spinning wound dressing, and belongs to the field of application materials and technologies. The COFs are synthesized from cobalt hexafluorophthalocyanine (CoPcF16) and ellagic acid (EA). The COFs is prepared into the spinning membrane, and the COFs spinning membrane has very strong oxidation resistance, can effectively remove excessive endogenous ROS, can respond to near infrared to generate exogenous ROS, and can effectively kill bacteria at a wound and improve blood flow and healing of the wound. The COFs spinning membrane prepared by the invention is simple and convenient in preparation method, good in biocompatibility, strong in oxidation resistance and capable of responding to near infrared to produce ROS, and has strong application potential in the field of treatment of a series of infected wounds, especially treatment of diabetic foot ulcers.

The invention relates to the field of wound dressings and the field of flexible strain sensors, in particular to an intelligent wound dressing with drug controlled release and motion detection functions and a preparation method of the intelligent wound dressing. The wound dressing comprises thermoplastic polyurethane, liquid metal, lauric acid and curcumin, a TPU elastic material serves as a substrate, the liquid metal serves as a photo-thermal agent and a sensor flexible circuit part, the motion monitoring function can be achieved, and good biocompatibility is achieved; lauric acid is used as a thermal phase change material, curcumin is used as a bioactive drug, and photo-thermal response drug controlled release is achieved; the intelligent wound dressing with photo-thermal drug controlled release and motion monitoring functions is prepared by combining electrostatic spinning, electrostatic spraying and template printing technologies, and has a wide application prospect in the field of wound dressings.

The invention discloses an antibacterial hyaluronic acid wound dressing with a core-shell structure and a preparation method of the antibacterial hyaluronic acid wound dressing, and belongs to the field of biomedical materials. The core-shell structure nanofiber is prepared by adopting a coaxial electrospinning technology, and the preparation mode is superior to the solid structure nanofiber prepared by common electrospinning. According to the invention, polyvinyl butyral, a polyethylene oxide solution, zein and a modified hyaluronic acid solution are simultaneously sprayed out by using concentrically arranged nozzles, and are drawn into fibers by using electrostatic force, so that drugs wrapped in the fiber structure can realize controlled release and lasting effects; and a new scheme is provided for preparation of wound dressing.

The invention discloses a preparation method and application of a marine high-molecular polysaccharide hydrogel wound dressing. The hydrogel is formed by cross-linking the marine polysaccharide composition and the cross-linking agent, and the gelation time is short and is about 15 seconds; pores are uniform and moderate; the self-healing property, the adhesion property and the swelling property are high; the antibacterial effect is strong, and the inhibition rates on escherichia coli and staphylococcus aureus are both higher than 90%; skin irritation and skin allergy are avoided, and the biological safety is high; hemostasis can be rapidly carried out within 10s, and the bleeding amount is obviously reduced; the hydrogel dressing can rapidly shrink and scab a wound surface, has the effect of promoting wound healing, and has the effects of stopping bleeding and promoting wound healing which are obviously superior to those of commercially available hydrogel dressings (German Hydrosorb Gel) (Plt; 0.05), and is a safe and effective high-performance wound dressing. In addition, the hydrogel is simple in formula and high in industrialization prospect, is expected to be developed into novel wound dressings and medical instruments, and breaks through the trapping that domestic hydrogel dressings are mostly dependent on import.

The invention discloses a polylipoic acid-based composite sponge wound dressing and a preparation method and application thereof.The preparation method comprises the following steps that polylipoic acid amide with amino is obtained through disulfide bond ring opening polymerization, and the polylipoic acid amide and an aldehyde cross-linking agent are jointly dissolved in ethyl alcohol to form a solution A; carrying out high-speed shearing, dispersing and foaming on the water-soluble polymer, and freeze-drying to form porous sponge B; the porous sponge B is soaked in the solution A to be subjected to a cross-linking reaction, vacuum drying is conducted, and the polylipoic acid-based composite sponge wound dressing is obtained. The preparation method has the characteristics of simple preparation process, safety and no toxicity, the polylipoic acid with excellent oxidation resistance is introduced into the medical sponge material, the preparation method of the polylipoic acid medical porous structure material is obtained, the oxidation resistance and the wet viscosity of the medical sponge material are improved, and the medical sponge material has good application prospects. The application of the polylipoic acid-based porous material in the fields of hemostatic materials and wound dressings is realized.