54 results about "Angioplasty" patented technology

Pulsatile balloon catheter systems are provided. Aspects of the systems include: a pulse generator; and a balloon catheter assembly operably connected to the pulse generator. In embodiments, the balloon catheter assembly includes: a proximal connector operably connecting the balloon catheter assembly to the pulse generator and configured to transduce a first pulse energy generated by the pulse generator to a second pulse energy; a distal balloon; and a catheter component, where the catheter component includes a fluidic passage operably positioned between the proximal connector and the distal balloon, which passage is configured to propagate the second pulse energy from the proximal connector along the fluid passage to the distal balloon. Also provided are balloon catheter assemblies and kits that include the same. Also provided are systems and methods for assessing vessel compliance in-vivo. Also provided are systems and methods for determining system state of balloon catheter systems. The systems, assemblies and kits find use in a variety of different applications, including balloon angioplasty applications.

Systems and methods can involve wedge dissectors attached to strips in turn attached to medical balloons, for forming serrations within vascular wall tissue for angioplasty as well as drug delivery.

Microcatheter systems for crossing total occlusions are provided. Aspects of the systems include: a microcatheter with proximal and distal regions, the distal region comprising a fixed, sealed end, wherein the microcatheter comprises a lumen that receives liquid and gas, a fluid introduction module for introducing liquid and gas into the microcatheter lumen and an actuator that repeatedly pressurizes a liquid and gas mixture present within the microcatheter lumen such that the distal region of the microcatheter vibrates, moving the microcatheter across a total occlusion. Also provided are methods for modulating a total occlusion, e.g., by crossing a total occlusion or modifying a proximal cap thereof, e.g., by producing a divot or hole in the proximal cap. The systems and methods find use in a variety of different applications, including balloon angioplasty applications or other catheter-based therapies or treatments, such as conditions in which a total occlusion may be present in a vessel, including, for example, cardiovascular disease.

Pulsatile balloon catheter systems are provided. Aspects of the systems include: a pulse generator; and a balloon catheter assembly operably connected to the pulse generator. In embodiments, the balloon catheter assembly includes: a proximal connector operably connecting the balloon catheter assembly to the pulse generator and configured to transduce a first pulse energy generated by the pulse generator to a second pulse energy; a distal balloon; and a catheter component, where the catheter component includes a fluidic passage operably positioned between the proximal connector and the distal balloon, which passage is configured to propagate the second pulse energy from the proximal connector along the fluid passage to the distal balloon. Also provided are balloon catheter assemblies and kits that include the same. Also provided are systems and methods for assessing vessel compliance in-vivo. Also provided are systems and methods for determining system state of balloon catheter systems. The systems, assemblies and kits find use in a variety of different applications, including balloon angioplasty applications.

A balloon expandable stent having multiple rings and cells with ultra-thin struts, wherein the sizes of the cells are larger proximally and varies amongst the rings, enabling the stent to expand to a larger diameter at its proximal end compared with the distal end. A conical shape rather than the classic cylindrical design post deployment ensures adequate opposition of the stent to the arterial wall and avoids supramaximal expansion at the distal end. A unique monorail angioplasty balloon catheter delivers the stent through tortuous intracranial arteries with longer working length. A longer segment with traversing microwire enables modification in stiffness depending on stiffness of microwire, and reduction in length of segment with a hypotube alone.

The application relates to substituted hydantoinamides of formula (I) as ADAMTS7 antagonists, to processes for their preparation, their use alone or in combination for the treatment or prophylaxis of diseases, in particular of cardiovascular diseases, including atherosclerosis, coronary artery disease (CAD), peripheral vascular disease (PAD), arterial occlusive disease or restenosis after angioplasty. R1 is hydrogen, alkyl, cycloalkyl, heterocycloalkyl, heteroaryl or phenyl; R2 is hydrogen, cyano, halogen, alkylsulfonyl, alkyl, cycloalkyl or alkoxy; R3, R4, R5, R6, R7 and R8 are independently hydrogen, halogen, alkyl or alkoxy; most groups being optionally substituted; with the proviso that at least one of R2, R3, R4 is H; X1, X2, X3, X4, X5 and X6 are independently N or C; with the proviso that in each ring maximal one X is N.

Systems, devices, and methods are provided for drug delivery and vascular remodeling, particularly the use of a high-energy electromagnetic field to impart kinetic energy to the drug molecule or to tough calcific lesions during balloon angioplasty. The receiver is capable of absorbing electromagnetic energy and configured to oscillate upon absorbing electromagnetic energy, wherein oscillation of the receiver creates a physical motion that imparts kinetic energy to one or more drug molecules and enables or enhances penetration and / or diffusion of the drug molecules into a selected tissue. Embodiments are also provided in which a balloon catheter, with or without a drug-coated stent, comprises the receiver.

Various embodiments of the systems, methods and devices are provided comprising angioplasty to break up calcification or other tissue in occlusive areas within a blood vessel. The various embodiments disclosed comprise pressure pulse periods designed to break up calcified occlusive material through a cyclically stretching of the vessel walls without damaging the vessel wall tissue.

Methods, devices, and systems establish and facilitate retrograde or reverse flow blood circulation in the region of the carotid artery bifurcation in order to limit or prevent the release of emboli into the cerebral vasculature such as into the internal carotid artery. The methods are particularly useful for interventional procedures, such as stenting and angioplasty, atherectomy performed through a transcarotid approach or transfemoral into the common carotid artery, either using an open surgical technique or using a percutaneous technique, such as a modified Seldinger technique or a micropuncture technique.

The application discloses a drug-loaded balloon catheter system, which comprises a balloon body having opposite inflation states and a contraction state suitable for interventional delivery, a balloon wall of the balloon body being provided with a porous structure, an outer wall of the balloon body being loaded with a coating containing a first active cross-linking agent and a water-soluble sustained-release layer wrapping the coating; a catheter having opposite distal and proximal ends, wherein the distal end is in communication with the balloon body; a perfusion device for supplying a second active cross-linking agent into the balloon body in a fluid manner through the proximal end of the catheter; and a light source device for applying light to the first and second active cross-linking agents. The drug-loaded balloon catheter system can improve the effect of angioplasty.

Various embodiments of the systems, methods and devices are provided comprising angioplasty to break up calcification or other tissue in occlusive areas within a blood vessel. The various embodiments disclosed comprise pressure pulse periods designed to break up calcified occlusive material through a cyclically stretching of the vessel walls without damaging the vessel wall tissue.

The invention relates to a catheter system for carrying out an angioplasty, comprising an outer shaft which extends in an axial direction and has a distal end, an inner shaft which can be moved therein in the axial direction and has a distal end, and a rolling membrane which is connected to the distal end of the outer shaft and the distal end of the inner shaft in a pressure-tight manner, and which can be moved between a rolled-in position within the outer shaft and a position in which it is rolled out distally from the outer shaft by applying pressure.

Systems and methods can involve wedge dissectors attached to strips in turn attached to medical balloons, for forming serrations within vascular wall tissue for angioplasty as well as drug delivery. Such balloon blowing techniques can reduce the balloon profile, the material costs, and the manufacturing time to build a serrated balloon catheter device. The design and process to build this type of balloon is described herein.

The present disclosure relates to an inflation device (1; 101) for inflating at least one angioplasty product (6) comprising a product interface (38) provided and configured for fluidic connection of the at least one angioplasty product (6), a fluid conveying interface (36) fluidically connectable or connected to the product interface (38) and provided and configured for fluidic connection to a fluid conveying device (10), a drive unit (30) provided and configured for driving the fluid conveying device (10), a pressure sensing unit (40) provided and configured for sensing a pressure in a pressure chamber (32), and a control unit (12) that is signal-connected to and provided and configured for the drive unit (30) and the pressure sensing unit (40).The drive unit (30) is controlled depending on the detected pressure (p) and a target pressure (pD) corresponding to a target diameter (D) of the angioplasty product (6), wherein a storage unit (12) is provided in which an assignment of time-dependent target pressure profiles (42, 44, 46, 48, 50, 52) to foreseeable angioplasty products (6) is stored in a retrievable manner, and the control device (12) is designed and configured to control the drive unit (30) depending on the assigned, time-dependent target pressure profile (42, 44, 46, 48, 50, 52). The present disclosure further relates to an inflation arrangement (200) for angioplasty and a medical system (100) for angioplasty.

The present invention relates to a device (4) for automatically inflating a vascular balloon catheter (6) with a fluid, the device (4) comprising a catheter interface (8), a fluid supply device (12), a pressure sensor device (16), and a control device (18). The catheter interface (8) is particularly designed to be removably connectable to the balloon catheter (6) without tools, thereby allowing fluid to flow from the device (4) to the balloon catheter (6) via the catheter interface (8). The fluid supply device (12) is designed to discharge fluid from the device (4) at the catheter interface (8) by a motor (32). The pressure sensor device (16) is designed to measure the pressure of the fluid discharged from the device (4). The control device (18) is designed to control the amount of fluid discharged from the device (4) by the fluid supply device (12) by driving the motor (32) of the fluid supply device (12) based on the pressure measured by the pressure sensor device (16). According to the present disclosure, the fluid supply device (12) is designed to allow fluid to be drawn into the device (4) at the catheter interface (8) by a motor (32). The present disclosure further relates to a system (2; 102; 202; 302) for performing angioplasty, comprising a balloon catheter (6) and a device (4) according to the present disclosure.

An endovascular lithotripsy system having an angioplasty-like balloon capable of being filled with a fluid, such as including brine, which may be mixed with or otherwise provided with known other fluid components, such as contrast agents. The system may include at least one emitter or electrode pair for generating therapy. For example, energy waves or high-pressure acoustic energy waves within a balloon having a fluid inside may provide treatment. The system also includes a sensor for detecting damage to the balloon, such as a rupture. The system also includes a control module having a processor for receiving information about balloon injury or rupture and the ability of the system to prevent energy supply to the emitter or electrode upon detection of balloon injury or unacceptable degradation or impending predicted failure.

A balloon expandable stent having multiple rings and cells with ultra-thin struts, wherein the sizes of the cells are larger proximally and varies amongst the rings, enabling the stent to expand to a larger diameter at its proximal end compared with the distal end. A conical shape rather than the classic cylindrical design post deployment ensures adequate opposition of the stent to the arterial wall and avoids supramaximal expansion at the distal end. A unique monorail angioplasty balloon catheter delivers the stent through tortuous intracranial arteries with longer working length. A longer segment with traversing microwire enables modification in stiffness depending on stiffness of microwire, and reduction in length of segment with a hypotube alone.

Microcatheter systems for crossing total occlusions are provided. Aspects of the systems include: a microcatheter with proximal and distal regions, the distal region comprising a fixed, sealed end, wherein the microcatheter comprises a lumen that receives liquid and gas, a fluid introduction module for introducing liquid and gas into the microcatheter lumen and an actuator that repeatedly pressurizes a liquid and gas mixture present within the microcatheter lumen such that the distal region of the microcatheter vibrates, moving the microcatheter across a total occlusion. Also provided are methods for modulating a total occlusion, e.g., by crossing a total occlusion or modifying a proximal cap thereof, e.g., by producing a divot or hole in the proximal cap. The systems and methods find use in a variety of different applications, including balloon angioplasty applications or other catheter-based therapies or treatments, such as conditions in which a total occlusion may be present in a vessel, including, for example, cardiovascular disease.

The invention relates to an inflation device (1) for inflating an angioplasty product (6), comprising: a provided angioplasty product (6) having a marking (KA) which contains an identifier and / or at least one nominal size of the provided angioplasty product (6); and a reader unit (2) which is intended and designed to detect the marking (KA) of at least the provided angioplasty product (6), wherein a memory unit (14) is provided in which a mapping between at least one suitable inflation syringe (10) and the provided angioplasty product (6) is stored, and wherein a control unit (12) of the inflation device (1) is or can be connected for data transmission to the reader unit (2), and is intended and designed to determine the identifier and / or the at least one nominal size of the provided angioplasty product (6) from the marking (KA) of the provided angioplasty product (6), and, depending on the determined identifier and / or the determined at least one nominal size of the provided angioplasty product (6), to determine and output the at least one suitable inflation syringe (10) from the mapping.

The ultrasonic system includes an ultrasonic device having an ultrasonic transducer and a core wire having a proximal end coupled to the ultrasonic transducer and a distal end portion terminating at a distal tip. An ultrasonic energy source is electrically connected to the ultrasonic transducer. The ultrasonic energy source includes an ultrasonic signal generator circuit, a modulator circuit, and a controller. The ultrasonic signal generator circuit generates an ultrasonic electrical signal. The modulator circuit amplitude-modulates the ultrasonic electrical signal with a macromotion electrical signal to generate a modulated ultrasonic electrical signal. The controller executes program instructions to select between an engagement mode and a transverse mode, where in the engagement mode, a first ultrasonic electrical signal is provided from the ultrasonic energy source to the ultrasonic transducer, and in the transverse mode, a modulated ultrasonic electrical signal is provided from the ultrasonic energy source to the ultrasonic transducer.

The invention relates to a combination for replacing a heart valve or for coronary angioplasty, with an insertion sheath (13) of an introducer (1) or a delivery catheter (1') which is smaller in size than the introducer, for insertion in an artery of the body. The invention consists essentially in that either a metal support for an electrode of a heart pacemaker is integrated in the member assembled around the insertion sheath, which is inserted in an artery of the patient or in a guide wire which becomes a bipolar support for the electrode; or a cathode of an external heart pacemaker is connected to a guide wire of an artificial valve and an anode of the heart pacemaker is connected to a transcutaneous electrode which is in contact with the skin of the patient.

The invention relates to the technical field of medical instruments, discloses a blood vessel supporting device for internal fistula plasty, and solves the problems that blocking formed at the suture position of an existing blood vessel supporting device can block the operation visual field, influence the operation space of inner face suture and enable suture operation to be inconvenient. On the premise that the traction line occupies a very small operation space, the first supporting mechanism and the second supporting mechanism are promoted to mutually form stable supporting, it is ensured that the surgical incision of the first blood vessel and the surgical incision of the second blood vessel are precisely matched, and convenient conditions are created for follow-up surgical incision inner face sewing. And sufficient space is provided for the needle to be inserted into the blood vessel.

The present disclosure relates to an inflation device (1) for inflating an angioplasty product (6), comprising an intended angioplasty product (6) with a marking (KA) which includes an identifier and / or at least a nominal size of the intended angioplasty product (6), and a reading unit (2) which is intended and configured to detect the marking (KA) of at least the intended angioplasty product (6), wherein a storage unit (12) is provided in which an assignment of at least one suitable inflation syringe (10) to the intended angioplasty product (6) is stored, and a control unit (12) of the inflation device (1) is data-connectable or data-linked to the reading unit (2), and is intended and configured for this purpose.to determine the identifier and / or at least one nominal size of the intended angioplasty product (6) from the marking (KA) of the intended angioplasty product (6) and, depending on the determined identifier and / or at least one nominal size of the intended angioplasty product (6), to determine and dispense at least one suitable inflation syringe (10) from the assignment. Furthermore, a method for configuring an inflation device is disclosed.

We provide a pulsating balloon catheter system. [Solution] The system comprises a pulse generator and a balloon catheter assembly operably connected to the pulse generator. In the embodiment, the balloon catheter assembly comprises a proximal connector configured to operably connect the balloon catheter assembly to the pulse generator and convert a first pulse energy generated by the pulse generator into a second pulse energy, a distal balloon, and a catheter component, the catheter component comprising a fluid passage operably positioned between the proximal connector and the distal balloon, the fluid passage configured to propagate the second pulse energy from the proximal connector along the fluid passage to the distal balloon. The system, assembly, and kit find use in a variety of different applications, including balloon angioplasty applications.

The invention discloses a TAAD postoperative sleep deprivation risk assessment method based on three-party collaboration, and relates to the field of medical health, and the assessment method comprises the following steps: a digital collaboration platform collects sleep associated data of a patient party, a medical party and a hospital organization management party; constructing a TAAD postoperative sleep deprivation risk assessment model in combination with the sleep associated data; the TAAD postoperative sleep deprivation risk assessment model assesses the real-time sleep associated data collected by the digital collaboration platform and outputs a TAAD postoperative sleep deprivation risk probability value; setting three levels of early warning thresholds respectively corresponding to low, medium and high risk assessment results of sleep deprivation, and generating personalized sleep suggestions, adjusting nursing schemes and environment intervention measures; and the digital cooperation platform pushes personalized sleep suggestions to the patient side, pushes an adjustment nursing scheme to the medical side, and pushes an environment intervention scheme to the hospital organization management side. Through a multi-dimensional cooperation mechanism, the evaluation and intervention efficiency of the postoperative sleep deprivation risk is comprehensively improved.

A catheter system includes a rolling membrane guiding catheter and a docking unit. The docking unit is configured to automatically insert a plurality of devices into the rolling membrane guiding catheter.

This invention discloses a pulse-release balloon dilation pump and method for intracranial arterial stenosis. Addressing the mechanical mechanism of thin intracranial arterial walls and irregular plaques leading to axial stress accumulation and subsequent complications such as dissection and detachment, this invention adds a pulse-release control unit to a conventional pressure pump. Its core physical principle is as follows: When the balloon dilates at an irregular plaque, the intramural strain energy density distribution is uneven. Static friction constraint keeps the system in a high-energy metastable state, and the accumulated elastic potential energy ΔU continuously increases with expansion. The constraint factor λ is defined as F_required / f_max; when λ>1, the balance is unstable, and energy suddenly bursts. This invention uses periodic short-term pressure release to instantaneously decrease the contact pressure, reduce the static friction limit, and briefly raise λ to >1, actively triggering micro-slippage, releasing a small portion of the accumulated energy each time, achieving segmented and gentle energy release. Pulse parameters (amplitude, frequency, etc.) can be flexibly adjusted according to actual clinical conditions. The pulse mode offers flexible and diverse usage options. Operators can initiate it synchronously in the early stages of dilation, when risk signs appear, intervene as needed during pressure application, or combine multiple methods, allowing the operator to independently determine the operational procedure. Based on thin-film mechanics, tribology, and viscoelasticity theories, this invention is simple to operate, does not alter the clinical procedure, and effectively reduces the risk of complications during intracranial artery stenosis balloon angioplasty.

The invention relates to a device (4) for the automatic inflation of a vascular balloon catheter (6) by means of a fluid, comprising a fluid delivery device (12), a pressure sensor device (16) and a control device (18), a catheter interface (8) being designed to be detachably connected to the balloon catheter (6), in particular without tools, the invention relates to a balloon catheter (6) comprising a device (4) having a catheter interface (8), a fluid delivery means (12) configured to be able to discharge fluid from the device (4) at the catheter interface (8) by means of a motor (32), and a pressure sensor means (16) configured to be able to measure the pressure of the fluid discharged by the device (4), such that the fluid can flow from the device (4) into the balloon catheter (6) via the catheter interface (8), the fluid delivery means (12) being configured to discharge the fluid from the device (4) at the catheter interface (8), and the pressure sensor means (16) being configured to measure the pressure of the fluid discharged by the device (4). The control means (18) are designed to control the amount of fluid discharged from the device (4) by means of the fluid conveying means (12), depending on the pressure measured by the pressure sensor means (16), by actuating a motor (32) of the fluid conveying means (12).

A method for reducing a composite endpoint risk of myocardial infarction (MI), stroke, coronary revascularization, unstable angina requiring hospitalization, cardiac arrest, and cardiovascular death in a subject including administering, orally once per day to the subject, a composition comprising about 0.5 total mg of (i) colchicine, (ii) a pharmaceutically acceptable salt of (i), or any combination of (i) and (ii), wherein the patient has at least one history of diabetes, a past myocardial infarction, an unstable angina, a coronary bypass surgery, and a coronary angioplasty; wherein the patient is also administered a daily dose of statin therapy; and wherein the composite endpoint risk in the subject is reduced relative to a dosing regimen where the patient receives standard secondary prevention therapy of a statin.