74 results about "Angioplasty" patented technology

Described herein are low-profile electrodes for use with an angioplasty shockwave catheter. A low-profile electrode assembly may have an inner electrode, an insulating layer disposed over the inner electrode such that an opening in the insulating layer is aligned with the inner electrode, and an outer electrode sheath disposed over the insulating layer such that an opening in the outer electrode sheath is coaxially aligned with the opening in the insulating layer. This layered configuration allows for the generation of shockwaves that propagate outward from the side of the catheter. In some variations, the electrode assembly has a second inner electrode, and the insulating layer and outer electrode may each have a second opening that are coaxially aligned with the second inner electrode. An angioplasty shockwave catheter may have a plurality of such low-profile electrode assemblies along its length to break up calcified plaques along a length of a vessel.

Pulsatile balloon catheter systems are provided. Aspects of the systems include: a pulse generator; and a balloon catheter assembly operably connected to the pulse generator. In embodiments, the balloon catheter assembly includes: a proximal connector operably connecting the balloon catheter assembly to the pulse generator and configured to transduce a first pulse energy generated by the pulse generator to a second pulse energy; a distal balloon; and a catheter component, where the catheter component includes a fluidic passage operably positioned between the proximal connector and the distal balloon, which passage is configured to propagate the second pulse energy from the proximal connector along the fluid passage to the distal balloon. Also provided are balloon catheter assemblies and kits that include the same. Also provided are systems and methods for assessing vessel compliance in-vivo. Also provided are systems and methods for determining system state of balloon catheter systems. The systems, assemblies and kits find use in a variety of different applications, including balloon angioplasty applications.

Pulsatile balloon catheter systems are provided. Aspects of the systems include: a pulse generator; and a balloon catheter assembly operably connected to the pulse generator. In embodiments, the balloon catheter assembly includes: a proximal connector operably connecting the balloon catheter assembly to the pulse generator and configured to transduce a first pulse energy generated by the pulse generator to a second pulse energy; a distal balloon; and a catheter component, where the catheter component includes a fluidic passage operably positioned between the proximal connector and the distal balloon, which passage is configured to propagate the second pulse energy from the proximal connector along the fluid passage to the distal balloon. Also provided are balloon catheter assemblies and kits that include the same. Also provided are systems and methods for assessing vessel compliance in-vivo. Also provided are systems and methods for determining system state of balloon catheter systems. The systems, assemblies and kits find use in a variety of different applications, including balloon angioplasty applications.

Systems and methods can involve wedge dissectors attached to strips in turn attached to medical balloons, for forming serrations within vascular wall tissue for angioplasty as well reducing vessel recoil, reducing residual stenosis, and increasing volumetric blood flow post angioplasty. The design, methods of use, intended outcomes, and process to build this type of balloon is described herein.

Systems configured for performing atherectomy and pulsatile intravascular lithotripsy are provided. Aspects of the systems include a console; and a handle, wherein the handle is configured to be interchangeably operably connectable to: an atherectomy subsystem, and a pulsatile intravascular lithotripsy subsystem. Also provided are components of the systems that include the same. The systems and assemblies find use in a variety of different applications, including combined atherectomy and pulsatile intravascular lithotripsy procedures as well as balloon angioplasty applications.

Systems and methods can involve wedge dissectors attached to strips in turn attached to medical balloons, for forming serrations within vascular wall tissue for angioplasty as well as drug delivery.

Systems and methods can involve wedge dissectors attached to strips in turn attached to medical balloons, for forming serrations within vascular wall tissue for angioplasty as well as drug delivery.

Systems and methods can involve manufacturing medical balloons with wedge dissectors for forming serrations within vascular wall tissue for angioplasty, wherein the systems and methods include improved methods of forming the wedge dissectors and attaching the wedge dissectors to the medical balloon as well as a central shaft to increase the cross ability of the catheter to cross lesions. The design, methods of use, intended outcomes, and process to build this type of balloon is described herein.

Microcatheter systems for crossing total occlusions are provided. Aspects of the systems include: a microcatheter with proximal and distal regions, the distal region comprising a fixed, sealed end, wherein the microcatheter comprises a lumen that receives liquid and gas, a fluid introduction module for introducing liquid and gas into the microcatheter lumen and an actuator that repeatedly pressurizes a liquid and gas mixture present within the microcatheter lumen such that the distal region of the microcatheter vibrates, moving the microcatheter across a total occlusion. Also provided are methods for modulating a total occlusion, e.g., by crossing a total occlusion or modifying a proximal cap thereof, e.g., by producing a divot or hole in the proximal cap. The systems and methods find use in a variety of different applications, including balloon angioplasty applications or other catheter-based therapies or treatments, such as conditions in which a total occlusion may be present in a vessel, including, for example, cardiovascular disease.

Pulsatile balloon catheter systems are provided. Aspects of the systems include: a pulse generator; and a balloon catheter assembly operably connected to the pulse generator. In embodiments, the balloon catheter assembly includes: a proximal connector operably connecting the balloon catheter assembly to the pulse generator and configured to transduce a first pulse energy generated by the pulse generator to a second pulse energy; a distal balloon; and a catheter component, where the catheter component includes a fluidic passage operably positioned between the proximal connector and the distal balloon, which passage is configured to propagate the second pulse energy from the proximal connector along the fluid passage to the distal balloon. Also provided are balloon catheter assemblies and kits that include the same. Also provided are systems and methods for assessing vessel compliance in-vivo. Also provided are systems and methods for determining system state of balloon catheter systems. The systems, assemblies and kits find use in a variety of different applications, including balloon angioplasty applications.

An apparatus for performing angioplasty on a lesion and applying a therapeutic agent thereto. The apparatus includes a catheter having an inflatable balloon, such as a non-compliant balloon, adapted to compress the lesion when inflated. At least one port adapted to deliver the therapeutic agent to adjacent the lesion, such as once the balloon is deflated and advanced past a location where the inflatable balloon compressed the lesion. Alternatively, one or more additional balloons, which may be compliant balloons located distally or proximally of the balloon for compressing the lesion, may be inflated to form a sealed chamber including the compressed lesion and the therapeutic agent once delivered via the at least one port. Related methods are also disclosed.

A balloon expandable stent having multiple rings and cells with ultra-thin struts, wherein the sizes of the cells are larger proximally and varies amongst the rings, enabling the stent to expand to a larger diameter at its proximal end compared with the distal end. A conical shape rather than the classic cylindrical design post deployment ensures adequate opposition of the stent to the arterial wall and avoids supramaximal expansion at the distal end. A unique monorail angioplasty balloon catheter delivers the stent through tortuous intracranial arteries with longer working length. A longer segment with traversing microwire enables modification in stiffness depending on stiffness of microwire, and reduction in length of segment with a hypotube alone.

The application relates to substituted hydantoinamides of formula (I) as ADAMTS7 antagonists, to processes for their preparation, their use alone or in combination for the treatment or prophylaxis of diseases, in particular of cardiovascular diseases, including atherosclerosis, coronary artery disease (CAD), peripheral vascular disease (PAD), arterial occlusive disease or restenosis after angioplasty. R1 is hydrogen, alkyl, cycloalkyl, heterocycloalkyl, heteroaryl or phenyl; R2 is hydrogen, cyano, halogen, alkylsulfonyl, alkyl, cycloalkyl or alkoxy; R3, R4, R5, R6, R7 and R8 are independently hydrogen, halogen, alkyl or alkoxy; most groups being optionally substituted; with the proviso that at least one of R2, R3, R4 is H; X1, X2, X3, X4, X5 and X6 are independently N or C; with the proviso that in each ring maximal one X is N.

Systems, devices, and methods are provided for drug delivery and vascular remodeling, particularly the use of a high-energy electromagnetic field to impart kinetic energy to the drug molecule or to tough calcific lesions during balloon angioplasty. The receiver is capable of absorbing electromagnetic energy and configured to oscillate upon absorbing electromagnetic energy, wherein oscillation of the receiver creates a physical motion that imparts kinetic energy to one or more drug molecules and enables or enhances penetration and / or diffusion of the drug molecules into a selected tissue. Embodiments are also provided in which a balloon catheter, with or without a drug-coated stent, comprises the receiver.

Various embodiments of the systems, methods and devices are provided comprising angioplasty to break up calcification or other tissue in occlusive areas within a blood vessel. The various embodiments disclosed comprise pressure pulse periods designed to break up calcified occlusive material through a cyclically stretching of the vessel walls without damaging the vessel wall tissue.

Systems and methods may include wedge dissectors attached to strips, which in turn are attached to medical balloons, for forming teeth within vascular wall tissue for angioplasty and reducing vascular retraction, reducing residual stenosis, and increasing volumetric blood flow after angioplasty. Designs, methods of use, anticipated outcomes, and processes for constructing airbags of this type are described herein.

Methods, devices, and systems establish and facilitate retrograde or reverse flow blood circulation in the region of the carotid artery bifurcation in order to limit or prevent the release of emboli into the cerebral vasculature such as into the internal carotid artery. The methods are particularly useful for interventional procedures, such as stenting and angioplasty, atherectomy performed through a transcarotid approach or transfemoral into the common carotid artery, either using an open surgical technique or using a percutaneous technique, such as a modified Seldinger technique or a micropuncture technique.

The application discloses a drug-loaded balloon catheter system, which comprises a balloon body having opposite inflation states and a contraction state suitable for interventional delivery, a balloon wall of the balloon body being provided with a porous structure, an outer wall of the balloon body being loaded with a coating containing a first active cross-linking agent and a water-soluble sustained-release layer wrapping the coating; a catheter having opposite distal and proximal ends, wherein the distal end is in communication with the balloon body; a perfusion device for supplying a second active cross-linking agent into the balloon body in a fluid manner through the proximal end of the catheter; and a light source device for applying light to the first and second active cross-linking agents. The drug-loaded balloon catheter system can improve the effect of angioplasty.

A system includes a processor in communication with memory. The processor is configured to receive one or more images of an implantable device within a vasculature; extract, from the one or more images, at least one image feature indicating a position of the implantable device relative to a vessel wall of the vasculature; and select, based on the at least one image feature, at least one view for optimally observing a medical procedure to deploy the implantable device to the vessel wall.

Various embodiments of the systems, methods and devices are provided comprising angioplasty to break up calcification or other tissue in occlusive areas within a blood vessel. The various embodiments disclosed comprise pressure pulse periods designed to break up calcified occlusive material through a cyclically stretching of the vessel walls without damaging the vessel wall tissue.

The invention relates to a catheter system for carrying out an angioplasty, comprising an outer shaft which extends in an axial direction and has a distal end, an inner shaft which can be moved therein in the axial direction and has a distal end, and a rolling membrane which is connected to the distal end of the outer shaft and the distal end of the inner shaft in a pressure-tight manner, and which can be moved between a rolled-in position within the outer shaft and a position in which it is rolled out distally from the outer shaft by applying pressure.

Systems and methods can involve wedge dissectors attached to strips in turn attached to medical balloons, for forming serrations within vascular wall tissue for angioplasty as well as drug delivery. Such balloon blowing techniques can reduce the balloon profile, the material costs, and the manufacturing time to build a serrated balloon catheter device. The design and process to build this type of balloon is described herein.

The present disclosure relates to an inflation device (1; 101) for inflating at least one angioplasty product (6) comprising a product interface (38) provided and configured for fluidic connection of the at least one angioplasty product (6), a fluid conveying interface (36) fluidically connectable or connected to the product interface (38) and provided and configured for fluidic connection to a fluid conveying device (10), a drive unit (30) provided and configured for driving the fluid conveying device (10), a pressure sensing unit (40) provided and configured for sensing a pressure in a pressure chamber (32), and a control unit (12) that is signal-connected to and provided and configured for the drive unit (30) and the pressure sensing unit (40).The drive unit (30) is controlled depending on the detected pressure (p) and a target pressure (pD) corresponding to a target diameter (D) of the angioplasty product (6), wherein a storage unit (12) is provided in which an assignment of time-dependent target pressure profiles (42, 44, 46, 48, 50, 52) to foreseeable angioplasty products (6) is stored in a retrievable manner, and the control device (12) is designed and configured to control the drive unit (30) depending on the assigned, time-dependent target pressure profile (42, 44, 46, 48, 50, 52). The present disclosure further relates to an inflation arrangement (200) for angioplasty and a medical system (100) for angioplasty.

The present invention relates to a device (4) for automatically inflating a vascular balloon catheter (6) with a fluid, the device (4) comprising a catheter interface (8), a fluid supply device (12), a pressure sensor device (16), and a control device (18). The catheter interface (8) is particularly designed to be removably connectable to the balloon catheter (6) without tools, thereby allowing fluid to flow from the device (4) to the balloon catheter (6) via the catheter interface (8). The fluid supply device (12) is designed to discharge fluid from the device (4) at the catheter interface (8) by a motor (32). The pressure sensor device (16) is designed to measure the pressure of the fluid discharged from the device (4). The control device (18) is designed to control the amount of fluid discharged from the device (4) by the fluid supply device (12) by driving the motor (32) of the fluid supply device (12) based on the pressure measured by the pressure sensor device (16). According to the present disclosure, the fluid supply device (12) is designed to allow fluid to be drawn into the device (4) at the catheter interface (8) by a motor (32). The present disclosure further relates to a system (2; 102; 202; 302) for performing angioplasty, comprising a balloon catheter (6) and a device (4) according to the present disclosure.

An endovascular lithotripsy system having an angioplasty-like balloon capable of being filled with a fluid, such as including brine, which may be mixed with or otherwise provided with known other fluid components, such as contrast agents. The system may include at least one emitter or electrode pair for generating therapy. For example, energy waves or high-pressure acoustic energy waves within a balloon having a fluid inside may provide treatment. The system also includes a sensor for detecting damage to the balloon, such as a rupture. The system also includes a control module having a processor for receiving information about balloon injury or rupture and the ability of the system to prevent energy supply to the emitter or electrode upon detection of balloon injury or unacceptable degradation or impending predicted failure.

A balloon expandable stent having multiple rings and cells with ultra-thin struts, wherein the sizes of the cells are larger proximally and varies amongst the rings, enabling the stent to expand to a larger diameter at its proximal end compared with the distal end. A conical shape rather than the classic cylindrical design post deployment ensures adequate opposition of the stent to the arterial wall and avoids supramaximal expansion at the distal end. A unique monorail angioplasty balloon catheter delivers the stent through tortuous intracranial arteries with longer working length. A longer segment with traversing microwire enables modification in stiffness depending on stiffness of microwire, and reduction in length of segment with a hypotube alone.

Microcatheter systems for crossing total occlusions are provided. Aspects of the systems include: a microcatheter with proximal and distal regions, the distal region comprising a fixed, sealed end, wherein the microcatheter comprises a lumen that receives liquid and gas, a fluid introduction module for introducing liquid and gas into the microcatheter lumen and an actuator that repeatedly pressurizes a liquid and gas mixture present within the microcatheter lumen such that the distal region of the microcatheter vibrates, moving the microcatheter across a total occlusion. Also provided are methods for modulating a total occlusion, e.g., by crossing a total occlusion or modifying a proximal cap thereof, e.g., by producing a divot or hole in the proximal cap. The systems and methods find use in a variety of different applications, including balloon angioplasty applications or other catheter-based therapies or treatments, such as conditions in which a total occlusion may be present in a vessel, including, for example, cardiovascular disease.

A system is provided for imparting pulsatile energy to cardiovascular tissue. Aspects of the system include a console assembly having a potential source, a manifold assembly operably connected to the output of the console assembly and including an oscillator configured to generate pulsed energy from the energy transmitted from the potential source, and a catheter assembly operably connected to the output of the manifold assembly. The catheter assembly of the present invention includes a connector configured to operably connect the catheter assembly to the manifold assembly and convert a first pulsed energy generated by the manifold assembly into a second pulsed energy, a catheter having a fluid passage operably connected to the output of the connector and configured to transmit the second pulsed energy, and a heart tissue conforming element configured to receive the second pulsed energy transmitted through the fluid passage of the catheter and apply pulsatile energy to the cardiovascular tissue. Also provided is a method of imparting pulsatile energy to cardiovascular tissue, for example, deploying the system such that a heart tissue conforming element of the system is adjacent to the cardiovascular tissue and engaging the system in a manner such that the heart tissue conforming element imparts energy to the cardiovascular tissue. Additionally, a stand-alone catheter assembly and a kit comprising the components of the system described herein are provided. The system, assembly, method, and kit are utilized in a variety of different applications including balloon angioplasty applications or other catheter-based therapies or treatments.

The invention relates to an inflation device (1) for inflating an angioplasty product (6), comprising: a provided angioplasty product (6) having a marking (KA) which contains an identifier and / or at least one nominal size of the provided angioplasty product (6); and a reader unit (2) which is intended and designed to detect the marking (KA) of at least the provided angioplasty product (6), wherein a memory unit (14) is provided in which a mapping between at least one suitable inflation syringe (10) and the provided angioplasty product (6) is stored, and wherein a control unit (12) of the inflation device (1) is or can be connected for data transmission to the reader unit (2), and is intended and designed to determine the identifier and / or the at least one nominal size of the provided angioplasty product (6) from the marking (KA) of the provided angioplasty product (6), and, depending on the determined identifier and / or the determined at least one nominal size of the provided angioplasty product (6), to determine and output the at least one suitable inflation syringe (10) from the mapping.

The ultrasonic system includes an ultrasonic device having an ultrasonic transducer and a core wire having a proximal end coupled to the ultrasonic transducer and a distal end portion terminating at a distal tip. An ultrasonic energy source is electrically connected to the ultrasonic transducer. The ultrasonic energy source includes an ultrasonic signal generator circuit, a modulator circuit, and a controller. The ultrasonic signal generator circuit generates an ultrasonic electrical signal. The modulator circuit amplitude-modulates the ultrasonic electrical signal with a macromotion electrical signal to generate a modulated ultrasonic electrical signal. The controller executes program instructions to select between an engagement mode and a transverse mode, where in the engagement mode, a first ultrasonic electrical signal is provided from the ultrasonic energy source to the ultrasonic transducer, and in the transverse mode, a modulated ultrasonic electrical signal is provided from the ultrasonic energy source to the ultrasonic transducer.