108 results about "Tissue trauma" patented technology

The present invention relates to the use of a gene transfer product to reduce hyperplastic connective tissue growth after tissue trauma or implantation of a medical device. The present invention also relates to a medical device with improved biological properties for an at least partial contact with blood, bodily fluids and/or tissues when introduced in a mammalian body, which device comprises a core and a nucleic acid, encoding a product capable of leading to production of extracellular superoxide dismutase present in a biologically compatible medium. Said nucleic acid encodes a translation or transcription product, which is capable of inhibiting hyperplastic connective tissue growth and promoting endothelialisation in vivo at least partially on a synthetic surface of said core. The present invention also relates to a method of producing a medical device according to the invention.

The stent with an outer slough coating 125 of the present invention provides a coated stent having a permanent coating 130 disposed on the stent and a slough coating 125 disposed on the permanent coating 130. The permanent coating 130 includes an anti-proliferative agent and the slough coating 125 includes an anti-inflammatory agent. The slough coating 125 erodes shortly after stent implantation to deliver the anti-inflammatory agent, which treats tissue trauma from the angioplasty and the presence of the stent. Once the slough coating 125 has substantially eroded, the permanent coating 130 delivers the anti-proliferative agent long-term to prevent tissue growth on the stent or within the body lumen, and prevent restenosis. The permanent coating 130 can also include an anti-inflammatory agent.

A flexible medical intubation instrument provided for placement into an animal or human patient comprises a catheter with at least a pair of longitudinally extending lumens or channels including a sensor and/or actuator channel and a working channel. In the sensor/actuator channel is provided a fixed or slideably removable sensor cable having a sensor for sensing a characteristic or condition including any of the following: a visual sensor for optical viewing, a chemical sensor, a pH sensor, a pressure sensor, an infection sensor, an audio sensor, or a temperature sensor. The sensors are coupled by the sensor/actuator cable through light transmission, electric current, or radio transmission to a viewing instrument or other output device such as a meter or video screen for displaying the condition that is sensed within the body of the patient while the flexibility of the composite structure comprising the catheter and cable enable the entire instrument to flex laterally as it moves through curved passages or around obstructions during insertion or removal. While making observations through the sensor channel, the working channel simultaneously functions as a drain or an irrigation duct, a feeding tube, or to provide a passage for the insertion of one or a succession of surgical devices such that the catheter serves as a protective artificial tract or liner as surgical devices are inserted and removed through it in succession so as to minimize tissue trauma, infection, and pain experienced by the patient. The instrument can be used in urology, as well as a visually directed nasogastric tube, as a visually directed external gastrostomy tube, or as a visually directed internal gastric tube or percutaneous endoscopic gastrostomy tube and in other applications.

Tissue dressing assemblies are formed from hydrophilic polymer sponge structures. The tissue dressing assemblies can be used, e.g., (i) stanch, seal, or stabilize a site of tissue injury, tissue trauma, or tissue access; or (ii) form an anti-microbial barrier; or (iii) form an antiviral patch; or (iv) intervene in a bleeding disorder; or (v) release a therapeutic agent; or (vi) treat a mucosal surface; or (vii) combinations thereof. The tissue dressing structures are made compliant, e.g., by (i) micro-fracturing of a substantial portion of the sponge structure by mechanical manipulation prior to use, or (ii) a surface relief pattern formed on a substantial portion of the sponge structure prior to use, or (iii) a pattern of fluid inlet channels formed in a substantial portion of the sponge structure prior to use, or (iv) the impregnation of a sheet material within the sponge structure.

A flexible medical intubation instrument provided for placement into an animal or human patient comprises a catheter with at least one longitudinally extending lumen or channel. A fixed or slideably removable sensor cable is at least partially contained within the channel, having a sensor for sensing a characteristic or condition. While enabling observations through the sensor channel, the working channel may simultaneously function as a drain or an irrigation duct, a feeding tube, or to provide a passage for the insertion of one or a succession of surgical devices such that the catheter serves as a protective artificial tract or liner as surgical devices are inserted and removed through it in succession so as to minimize tissue trauma.

This invention relates to a periodontal instrument and curettage method for separating and removing calculus and diseased granulation tissue from the tooth surface and periodontal cavity in deep pockets greater than 10 mm. The invention is comprised of a straight shaft, a distal portion in parallel orientation with and terminating in a spoon-shaped blade with a rounded tip and continuous sharp edge. The approximate 90 degree angle orientation between the distal and proximal shank portions, rounded blade tip, and parallel alignment of the blade face relative to the distal shank portion enhance maneuverability, accessibility, and efficiency and minimize tissue trauma during periodontal curettage.

The present invention is directed to a combination of therapeutic compounds and treatment methods and kits using the combination. In particular, one of the combination affects the NCca-ATP channel of neural tissue, including neurons, glia and blood vessels within the nervous system. Exemplary SUR1 and/or TRPM4 antagonists that inhibit the NCca-ATP channel may be employed in the combination. The combination therapy also employs one or more of a non-selective cation channel blocker and/or an antagonist of VEFG, NOS, MMP, or thrombin. Exemplary indications for the combination therapy includes the prevention, diminution, and/or treatment of injured or diseased neural tissue, including astrocytes, neurons and capillary endothelial cells, that is due to ischemia, tissue trauma, brain swelling and increased tissue pressure, or other forms of brain or spinal cord disease or injury, for example. In other embodiments, there are methods and compositions directed to antagonists of TRPM4, including at least for therapeutic treatment of traumatic brain injury, cerebral ischemia, central nervous system (CNS) damage, peripheral nervous system (PNS) damage, cerebral hypoxia, or edema, for example.

A method comprises the steps of inserting a microneedle or micropuncture device into a body cavity to achieve a micropuncture into the cavity while reducing tissue trauma at a puncture site. A stepped or tapered guidewire having a reduced diameter distal portion is telescopically disposed through the inner diameter of the microneedle or Micropuncture device. A proximal portion of the guidewire has a diameter larger than the inner diameter of the microneedle or Micropuncture device and extends to a proximal end of the guidewire. The proximal portion is adapted for guiding a larger diameter instrument into and through the vascular system. The microneedle or micropuncture device is withdrawn from the micropuncture while leaving the distal portion of the guidewire extending through the micropuncture. The microneedle or micropuncture device is removed from the guidewire without removing the microneedle or Micropuncture device over the proximal end of the guidewire. As a result, tissue trauma at the puncture site is substantially reduced.

The present invention provides an absorbent wound dressing assembly that can be used to stanch, seal, or stabilize a site of tissue injury, tissue trauma, or tissue access. The wound dressing assembly is flexible so that it can be adapted and used to fit in narrow and small wound sites. Generally the wound dressing assembly comprises a flexible carrier material that is impregnated with a non-mammalian material for control of severe bleeding. The preferred non-mammalian material is poly [β-(1→4)-2-amino-2-deoxy-D-glucopyranose] more commonly referred to as chitosan.

A medical retrieval basket used for entrapping and extracting objects such as urinary and biliary calculi from the body comprising a handle assembly, a flexible shaft, and a basket. The basket comprises a plurality of outwardly disposed shape memory wires and is bulbous in shape at its distal end. Located at the intersection point of the wires at the distal end of the basket is a hub that restricts the degree of relative movement between the wires. This hub also serves to increase contact points with the object to be retrieved and to stabilize the orientation of the basket wires. The substantially tipless configuration of the distal end of the basket permits the basket to retrieve objects from difficult to reach locations and reduces tissue trauma caused by the basket tip. The basket wires have varying cross sectional shapes and sizes in different sections of the basket to optimize the performance to the needs of each section within the basket. The flexible shaft contains a drive wire that exhibits different flexibilities within the same strand of material by varied cross sectional shapes or diameters. This permits the distal section of the shaft to be more flexible, which reduces the possibility of the device shaft limiting the deflection of a flexible endoscope.

The inventor provides a surgical device that performs surgery with minimal tissue trauma and is adapted to access the surgical site by a trocar having a plurality of cannulas or by a conventional trocar. The invention including: (a) a plurality of elongated rods, each including a proximal end and a distal end; (b) a holder; (c) a functional element; and (d) a fairing; wherein each said proximal end is connectable to said holder; wherein each said distal end is connectable to said functional element; wherein said fairing removably covers said plurality of elongated rods. Method are provided.

Taurine and derivatives thereof may be used to repair the skin barrier, enhance hydration of the skin, prevent apoptosis and oxidative damage in the skin, and heal or prevent photo-induced skin damage. The presence of biogenic taurine or taurine derivatives in tissues and/or body fluids can be used as a biomarker for tissue trauma. Detection and/or quantification of such biogenic taurine or derivatives form the basis for an assay for determining the presence and/or extent of tissue damage.

A specimen retrieving needle is in the form of an elongated body having a closed lead end. At least one cutting blade may be formed on the body. The blade may have a sharpened edge so as to remove a specimen from an internal organ. The needle is ultrathin with an outside diameter of less than 1.0 mm to minimize tissue trauma and to reduce the risk of pain, hemorrhage and organ damage.

Methods for ameliorating tissue trauma from a surgical incision comprise making the surgical incision with a cutting instrument comprising a cutting instrument body defining two opposed sides and a direction of elongation, and having at least one cutting edge extending along the direction of elongation. The cutting edge defines an ultimate edge and two beveled faces adjacent the ultimate edge. The cutting edge of the cutting instrument has at least one characteristic selected from the group consisting of (a) a uniform ultimate edge having a maximum height deviation of 4 m or less along any 680 m segment of thereof; (b) each beveled face having a maximum height deviation of 4 m or less along any 680 m segment of thereof; and (c) each beveled face adjacent the ultimate edge having a root mean square surface roughness (Rq) of not more than about 200 nm. Improved cutting instruments are also provided.

The invention provides an intraoperative mobile C-arm X-ray machine positioning auxiliary device, comprising: a C-shaped arm, which is arranged on a bracket, and the C-shaped arm can rotate and slide along the bracket; an image receiving intensifier, which is arranged on the bracket One end of the C-shaped arm; emitting X-ray tube, which is arranged on the other end of the C-shaped arm, and above the image receiving intensifier; 4 laser generators, which are equidistantly arranged on the emitting On the circumference of the X-ray tube, the connecting lines of the four laser generators are in the shape of a "ten", the power of the laser generators is less than 5mmw, and the wavelength is 650nm. The intraoperative mobile C-arm X-ray machine positioning auxiliary device provided by the present invention has a simple structure and low cost, enables doctors to quickly and accurately determine the shooting range during the operation, has high precision and good stability, significantly reduces the number of fluoroscopy times, and improves operation safety. Sex, shorten operation time, reduce radiation exposure caused by repeated fluoroscopy, reduce tissue trauma and complications, and reduce radiation damage to patients and medical staff.