35results about How to "Avoid depolarization" patented technology

The present invention is directed to a combination of therapeutic compounds and treatment methods and kits using the combination. In particular, one of the combination affects the NCca-ATP channel of neural tissue, including neurons, glia and blood vessels within the nervous system. Exemplary SUR1 and/or TRPM4 antagonists that inhibit the NCca-ATP channel may be employed in the combination. The combination therapy also employs one or more of a non-selective cation channel blocker and/or an antagonist of VEFG, NOS, MMP, or thrombin. Exemplary indications for the combination therapy includes the prevention, diminution, and/or treatment of injured or diseased neural tissue, including astrocytes, neurons and capillary endothelial cells, that is due to ischemia, tissue trauma, brain swelling and increased tissue pressure, or other forms of brain or spinal cord disease or injury, for example. In other embodiments, there are methods and compositions directed to antagonists of TRPM4, including at least for therapeutic treatment of traumatic brain injury, cerebral ischemia, central nervous system (CNS) damage, peripheral nervous system (PNS) damage, cerebral hypoxia, or edema, for example.

Provided herein are compositions comprising light-activated chimeric proteins expressed on plasma membranes and methods of using the same to selectively depolarize excitatory or inhibitory neurons.

Techniques are provided for use by an implantable medical device for determining optimal or preferred atrioventricular (AV) pacing delay values for use in pacing the heart. Briefly, the atria and ventricles are paced using an initial AV pacing delay set to a value less than an intrinsic AV conduction delay so that intrinsic ventricular depolarizations are avoided. An internal electrical cardiac signal is sensed and atrial evoked responses and subsequent ventricular evoked responses are identified therein. Time delays between the atrial and ventricular evoked responses are measured and then a preferred or optimal AV pacing delay value is determined based on: the initial AV pacing delay; the measured time delays between the atrial and ventricular evoked responses; and on a predetermined preferred time delay to be achieved between atrial and ventricular evoked responses. Similar procedures are employed in connection with atrial sensed events. A calibration procedure is also described.

The invention discloses a jacquard needle piece of a warp knitting machine. The jacquard needle piece of the warp knitting machine comprises a jacquard needle bed and a plurality of piezoelectric ceramic needle selecting pieces. The jacquard needle bed comprises a base plate, a needle embedding block and a limiting block, and one piezoelectric ceramic needle selecting piece is embedded in each needle embedding groove in the needle embedding block and one corresponding limiting groove in the limiting block. Each piezoelectric ceramic needle selecting piece comprises a middle substrate, a yarn guide needle and piezoelectric ceramic pieces arranged on the two sides of the middle substrate, each middle substrate is a carbon fiber substrate made of conductive carbon fiber materials, the middle substrate of each piezoelectric ceramic needle selecting piece is electrically connected with the electrodes in the piezoelectric ceramic pieces arranged on the two sides of the middle substrate, the middle substrates of all the piezoelectric ceramic needle selecting pieces are integrally connected through first guide wires to be electrically connected with the negative electrode of a driving power source of the warp knitting machine, and the outer electrodes of the piezoelectric ceramic pieces on the two sides of each middle substrate are respectively and electrically connected with the positive electrode of the driving power of the warp knitting machine through second guide wires. The jacquard needle piece of the warp knitting machine is low in manufacturing cost, high in production efficiency, long in service life, and capable of avoiding the accidents of depoissonization, leakage current and short circuit of the piezoelectric ceramic pieces.

A method of manufacturing a piezoelectric resonator includes forming first electrodes larger than vibrating electrodes in an area D1 including the vibrating electrodes on obverse and reverse surfaces of a piezoelectric substrate, and measuring the resonant frequency fr₁ of a resonator including the first electrodes. The thickness of a metallic thin film required for frequency adjustment is determined based on the measured resonant frequency. Then, second electrodes formed of the metallic thin film having the determined thickness are formed in an area D2 including at least the vibrating electrodes of the piezoelectric substrate. By removing unnecessary portions of the first and second electrodes, a pattern of the resulting vibrating electrodes is formed. Thus, high-accuracy frequency adjustment can be achieved without the need for complicated positioning.

The invention provides a self-injection structure for realizing isotropic medium output linearly polarized single-frequency laser and relates to the self-injection structure of a laser, in particular to a Tm<3+>:YAG (yttrium aluminum garnet) laser which performs end-pumped single-frequency self-injection. 785nm light enters a crystal from an end surface; end pumping is performed; a single longitudinal mode is selected by combining an F-P etalon with a volume grating, wherein the volume grating serves as an output cavity lens; after the light enters a light splitter, the generated laser enters a 1/2 wave plate and a Glan prism to form linearly polarized light; and a small part of light is reflected by a full-reflecting lens through a partial through lens, so that the linearly polarized light is re-injected into the crystal to be continuously oscillated to form a structure of a self-injection linearly polarized single-frequency laser. Due to the design of the whole machine, linearly polarized output in an isotropic crystal is realized by a self-injection method, and the linearly polarized and stable single-frequency laser with high power is obtained. The method is complete and accurate, and is applied to injection frequency locking technology study of a single Tm-doped isotropic medium including Tm<3+>:YAG. The application field includes the fields of optoelectronic countermeasure, laser radar, laser medicine and the like.

Provided is a packaging method for a while-drilling acoustic wave transducer. The while-drilling acoustic wave transducer comprises a rubber layer, an outer shell, a piezoelectric ceramic crystal and an electric connector, wherein the piezoelectric ceramic crystal and the electric connector are packaged in the outer shell. The packaging method comprises the following steps that (1), an electrode of the piezoelectric ceramic crystal and the electric connector are connected with each other through a lead and placed in a mold; (2), packaging materials are prepared, and the packaging materials are identical with the piezoelectric ceramic crystal in thermal expansion coefficient; (3), the mold is filled with the packaging materials which are heated to the melting point, the outer shell is formed after the packaging materials are cooled and solidified, and the packaging materials, the piezoelectric ceramic crystal and the electric connector are made to be packaged into a whole; and (4), the rubber layer is laid on the outer side of the outer shell. By means of the packaging method, it is guaranteed that the piezoelectric ceramic crystal in the transducer cannot be damaged in the packaging process, the rubber layer is laid on the outer side of the outer shell of the while-drilling acoustic wave transducer so as to resist vibration, and installation of the transducer is facilitated.

The invention relates to a method for the determination of the time from onset of atrial fibrillation to presentation in a patient comprising the steps of: providing a sample of a bodily fluid of said patient, determining the level of proANP (SEQ ID NO: 1) or fragments thereof in said sample, correlating the level of proANP or fragments thereof to the time from the onset of atrial fibrillation to presentation of said patient, wherein said fragments have a length of at least 6 amino acid residues.

REST ASSEMBLY FOR RECOVERING THE GEOELECTRIC FIELD, formed from: a laminate, steamed beech wood mattress base (2) with a 100% natural water-based varnish;

and a mattress (3) with a core (4) of latex made from a 100% natural emulsion of the resin of the Hevea brasiliensis tree, which latex is whipped and baked at 120 degrees without chemical additives. The mattress comprises: an anti-moisture ionising sheet (5) made of 100% natural steamed and pressed coconut fibre, with a central layer (6) of rocks of pink salt and white quartz; an antibacterial mesh (7) of bamboo fibre; and a cover (8) of fabric comprising 70% cashmere and 30% organic cotton, with a filling of 4 cm disposed on at least the upper part of the mattress and comprising 100% natural wool, a fabric of organic graphite and silver, and an aluminium plate (9) connected to an earthing device (10).

Embodiments of the present invention disclose a light guide plate assembly. The light guide plate assembly includes a light guide plate and an optical coupling member attached to the light guide plate. The optical coupling member includes a plate-like part and a plurality of prism parts formed on the plate-like part. Each of the plurality of prism parts has a planar top surface, the top surface engaging with a light exiting surface of the light guide plate, and each of the plurality of prism parts has a reflective side surface which is configured to reflect incident light towards a light exiting surface of the optical coupling member through total reflection. The present disclosure further discloses a display apparatus including the said light guide plate assembly.