30 results about "Cerebral hypoxia" patented technology

The invention relates to a method for extracting a common macrocarpium fruit total glycoside and application of the common macrocarpium fruit total glycoside serving as active ingredients to the preparation of hypoxia tolerant medicines. The method comprises the following steps of: boiling, performing enzymolysis for extracting and purifying. The pharmacodynamic test proves that the common macrocarpium fruit total glycoside extracted by the method can improve the cardio-cerebral hypoxia capacity of mice, enhance physical strength, improve antifatigue capacity of organisms, and promote the establishment of hypoxia tolerant acclimatization.

The present disclosure relates to the use of 2-iminobiotin for treating brain cell injury, in particular in adults. The treatment may be used for the treatment of cerebral hypoxia-ischemia and / or reperfusion injury, including one or more symptoms thereof. Provided are methods of treatment comprising administering a therapeutically effective dose of 2-iminobiotin to an individual in need thereof.

The invention relates to salvinorin compositions and uses thereof. Specifically, the invention relates to administering salvinorin compositions to treat diseases and disorders associated with vasoconstriction, vaso-occlusion, or disruption of blood flow and autoregulation. For example, salvinorin compositions may be administered to subjects with cardiac arrest, subarachnoid hemorrhage, stroke, cerebral vascular spasm, cerebral hypoxia / ischemia, cerebral artery occlusion, or any condition involved in autoregulation impairment.

The present invention is directed to a combination of therapeutic compounds and treatment methods and kits using the combination. In particular, one of the combination affects the NCCa-ATP channel of neural tissue, including neurons, glia and blood vessels within the nervous system. Exemplary SUR1 and / or TRPM4 antagonists that inhibit the NCCa-ATP channel may be employed in the combination. The combination therapy also employs one or more of a non-selective cation channel blocker and / or an antagonist of VEFG, NOS, MMP, or thrombin. Exemplary indications for the combination therapy includes the prevention, diminution, and / or treatment of injured or diseased neural tissue, including astrocytes, neurons and capillary endothelial cells, that is due to ischemia, tissue trauma, brain swelling and increased tissue pressure, or other forms of brain or spinal cord disease or injury, for example. In other embodiments, there are methods and compositions directed to antagonists of TRPM4, including at least for therapeutic treatment of traumatic brain injury, cerebral ischemia, central nervous system (CNS) damage, peripheral nervous system (PNS) damage, cerebral hypoxia, or edema, for example.

A method of reducing the occurrence of brain cell damage or death caused by transient cerebral hypoxia, ischemia, brain inflammation or a traumatic brain injury (TBI) event. The method typically comprises identifying a subject with transient cerebral hypoxia, ischemia, brain inflammation or a TBI, and within 24 hours of onset of the condition, administering to the subject a continuous intravenous infusion dose of methamphetamine in an amount sufficient to reduce the occurrence of brain cell damage or death caused by the condition. Preferably, the dose is increased in response to a delay in administration. The invention also relates to a method for modulating cytokine expression within the brain to treat such conditions.

The invention relates to the technical field of Chinese herbal medicines, and in particular relates to a traditional Chinese medicine preparation of an external oxygenation pill, and preparation and using methods thereof. The traditional Chinese medicine preparation comprises the following effective raw materials in parts by weight: 400-600 parts of pine pollen, 100-200 parts of acacia catechu, 50-100 parts of asarum sieboldii, 150-300 parts of siberian cocklour fruit, 100-200 parts of flos magnoliae liliflorae, 100-200 parts of Chinese honeylocust fruit, 80-150 parts of rhizoma nelumbinis, 100-200 parts of angelica dahurica and 100-300 parts of green Chinese onion. A soybean-shaped pill is prepared from the raw materials and is placed in a nostril; the most remarkable effect is achieved in cooperation with a fumigating therapy; after the pill is taken out, the nostril approaches the lower part of a bowl containing boiled fumigating drugs including 4-7 parts of flos magnoliae liliflorae, 15-25 parts of siberian cocklour fruit, 10-18 parts of angelica dahurica, 15-30 parts of lily and 5-15 parts of green Chinese onion, and is fumigated. The traditional Chinese medicine preparation has the advantages that the components are simple; a formula is reasonable; a remarkable treatment effect is achieved; cerebral hypoxia and headache caused by altitude stress and altitude anoxia, nasal obstruction and headache caused by rhinitis, dyspnea and pneumonia caused by cold and the like are mainly treated.

Salvinorin A for use in treating neurological injuries associated with cardiac arrest, treating stroke, or treating a cerebral artery occlusion, cerebral hypoxia / ischemia or cerebral vasospasm in a subject.

The invention discloses a cell beauty preparation, and the technical problem to be solved is to treat gynecological diseases and qi and blood caused by chloasma, senile plaque, pigmentation, acne, alopecia, psoriasis, vitiligo, hyperthyroidism, hypothyroidism, frailty, cold and dampness Deficiency, low immune function, cerebral anemia, cerebral hypoxia, fatigue and menopausal syndrome. This product is made of the following raw materials in mass ratio: ants 1-6000, pearl powder 1-3500, motherwort 1-2000, angelica 1-1500, bee pollen 1-2500, medlar 1-3000. Compared with the prior art, the present invention provides necessary and sufficient life substances to human tissue cells by nourishing the kidneys and essence, replenishing qi and nourishing blood, clearing the meridians, ensuring the integrity of the cell structure and the normal progress of metabolism, and making the tissue cells full of youth. Vitality, delaying the aging process of cells, and solving wrinkles, pigmentation, memory loss, and lack of energy caused by the inability of cells to carry out normal life activities.

A method of reducing the occurrence of brain cell damage or death caused by transient cerebral hypoxia / ischemia condition or a traumatic brain injury (TBI) event. The method typically comprises identifying a subject with a transient cerebral hypoxic and / or ischemic condition, or a TBI, and within 24 hours of onset of the condition, administering to the subject a continuous intravenous infusion dose of methamphetamine in an amount sufficient to reduce the occurrence of brain cell damage or death caused by the condition. Preferably, in addition to the continuous intravenous infusion dose, a bolus dose of methamphetamine is administered to the subject as soon as possible after onset of the condition or occurrence of the TBI event.

The invention relates to salvinorin compositions and uses thereof. Specifically, the invention relates to administering salvinorin compositions to treat diseases and disorders associated with vasoconstriction, vaso-occlusion, or disruption of blood flow and autoregulation. For example, salvinorin compositions may be administered to subjects with cardiac arrest, subarachnoid hemorrhage, stroke, cerebral vascular spasm, cerebral hypoxia / ischemia, cerebral artery occlusion, or any condition involved in autoregulation impairment.

The invention relates to a method for extracting a common macrocarpium fruit total glycoside and application of the common macrocarpium fruit total glycoside serving as active ingredients to the preparation of hypoxia tolerant medicines. The method comprises the following steps of: boiling, performing enzymolysis for extracting and purifying. The pharmacodynamic test proves that the common macrocarpium fruit total glycoside extracted by the method can improve the cardio-cerebral hypoxia capacity of mice, enhance physical strength, improve antifatigue capacity of organisms, and promote the establishment of hypoxia tolerant acclimatization.

The invention relates to a drinking water bottle with an oxygen increasing device and relates to a drinking water packaging product. The drinking water bottle with an oxygen increasing device is suitable for the occasion where the existing bottled drinking water is used. The freshness of the known bottled water is obviously reduced, and the freshness of the water is mainly related to the oxygen solubility of the water. In order to overcome the defect that the existing drinking water bottle cannot maintain the taste of water quality, the drinking water bottle with an oxygenation device provided by the present invention can not only hold drinking water, but also improve the oxygen solubility of drinking water before drinking, and improve the safety of bottled water. water quality. For brain hypoxia, excessive exercise, and high temperature weather, drinking oxygen-containing water is beneficial to the body. The drinking water bottle is composed of a water bottle main body, a main bottle cap, an attached bottle cap, an oxygen connecting tube, and an oxygen overflow bag. It consists of a connector, the bottom piece of the oxygen overflow bag, and the top piece of the oxygen overflow bag. (see Attachment).

The present invention is directed to a method of reducing the occurrence of neuronal cell damage, including death, caused by transient cerebral hypoxia and / or ischemia. The method comprises the steps of: diagnosing a subject having a transient cerebral hypoxic and / or ischemic condition; and within 16 hours after onset of the condition, administering to the subject a neuroprotective amount of a pharmaceutical agent. The pharmaceutical agent is preferably selected from the group consisting of: a central nervous system stimulant (CNSS), monoamine neurotransmitter, monoamine oxidase inhibitor (MAOI), tricyclic antidepressant (TCA), or a combination thereof. Preferred agents include amphetamines, methamphetamine, methylphenidate, methylenedioxymethamphetamine, or a combination thereof.

The invention discloses a production method of rhodiola and highland barley health wine with the function of preventing cerebral hypoxia, and belongs to the technical field of wine making. The invention utilizes Rhodiola rosea, coriander root and highland barley to co-ferment health-care wine, adopts the method of preliminary enzymolysis and extruding and puffing, not only effectively shortens the process time, but more importantly increases the content of active substances in Rhodiola rosea and coriander root. Utilization rate, combined with the mixed bacteria fermentation process in the subsequent fermentation, further improves the utilization rate of raw materials, and at the same time makes the whole process easy to control and improves the stability of the product. The obtained rhodiola highland barley health wine has the function of preventing brain hypoxia, and at the same time, the dissolution rate of the active ingredients in the rhodiola is high, and the bad flavor of the rhodiola itself is improved.

The invention relates to salvinorin compositions and uses thereof. Specifically, the invention relates to administering salvinorin compositions to treat diseases and disorders associated with vasoconstriction, vaso-occlusion, or disruption of blood flow and autoregulation. For example, salvinorin compositions may be administered to subjects with cardiac arrest, subarachnoid hemorrhage, stroke, cerebral vascular spasm, cerebral hypoxia / ischemia, cerebral artery occlusion, or any condition involved in autoregulation impairment.

The invention discloses a medicine for treating cardiovascular and cerebrovascular diseases. It is a traditional Chinese medicine injection prepared by extracting and purifying Radix Astragali and Panax notoginseng as raw materials, and adding appropriate amount of medicinal auxiliary materials, including injection, large infusion and freeze-dried powder injection. The invention also discloses a preparation method of the medicine. The medicine of the invention has good stability and long effective period, and can be used for intramuscular injection, intravenous injection or intravenous drip. Pharmacodynamic tests show that the medicine of the present invention has protective effects on cerebral ischemia and myocardial injury in SD rats caused by ischemia-reperfusion. It can significantly improve the ability of mice to withstand cerebral hypoxia, improve neurological symptoms and cerebral edema in rats with cerebral ischemia, and reduce pathological changes; it can obviously inhibit the overflow of LDH and CK during myocardial injury in rats caused by ischemia-reperfusion, and reduce serum LDH, CK activity, narrowing the range of myocardial infarction, for the treatment of cardiovascular and cerebrovascular diseases, rapid onset, definite curative effect, no toxic side effects.