6 results about "Cerebral hypoxia" patented technology

The invention relates to the technical field of pharmaceutical preparations, in particular to a traditional Chinese medicine composition for invigorating qi, blood, yin and yang and a preparation method and application thereof. The traditional Chinese medicine composition comprises the following raw materials: tortoise-shell glue, deer-horn glue, donkey-hide gelatin, ginseng, astragalus membranaceus, codonopsis pilosula and fructus lycii, and is prepared by fermenting the raw materials, and the mass ratio of the tortoise-shell glue to the deer-horn glue to the donkey-hide gelatin to the ginseng to the astragalus membranaceus to the codonopsis pilosula to the fructus lycii is 1: (0.5-2): (0.5-2): (1-4): (2-5): (2-6): (2-6). The fermented product obtained by fermenting the medicine raw materials through probiotics can be used for treating qi-blood yin-yang deficiency syndromes such as fatigue, myocardial ischemia, cerebral hypoxia and kidney essence deficiency and / or treating and preventing leukopenia caused by myelosuppression and / or DNA (deoxyribonucleic acid) reduction after radiation and / or hypoimmunity and plateau hypoxia. The effects of preventing sudden cardiac death and the like are obvious.

The invention relates to the technical field of medicine, in particular to a pharmaceutical composition for preventing and / or treating hypoxic injury and application, the pharmaceutical composition is prepared by compounding ginseng stem and leaf total saponins, ginkgo leaf extract and ligustrazine according to the mass ratio of (45-55): (45-55): (0.8-1.5); the hypoxia injury comprises cerebral hypoxia injury and myocardial hypoxia injury. The pharmaceutical composition provided by the invention has the functions of preventing and / or treating myocardial injury, brain tissue and motor hypofunction caused by hypoxia.

The application discloses a kind of functionalization exosome-traditional Chinese medicine small molecule composite preparation T-pEXOs@GB and its preparation method and application.The composite preparation encapsulates ginkgolide B (GB) in the exosome of healthy plasma, and is functionally modified neuron target peptide RVG (DSPE-PEG-RVG) on its surface, so that it has brain targeting and oxygen supply functions.The preparation method provided by the application can efficiently and controllably prepare the composite preparation with uniform particle size and good stability.The T-pEXOs@GB composite preparation of the application can be targeted to deliver to brain ischemia and hypoxia injury area, significantly reduce oxidative stress and inflammatory response, reduce cerebral infarction volume, improve neurological deficit score, and improve the survival rate of animal model, and can be used to prepare drugs for preventing and treating acute high altitude cerebral hypoxia, ischemic stroke, neonatal hypoxic-ischemic encephalopathy and other cerebral ischemia and hypoxia injury, and has good market prospect.

The invention discloses a microcirculation normal-pressure oxygen therapy auxiliary device which comprises an oxygen generator, an oxygen input pipe, a cooling module and an oxygen output pipe which are connected in sequence. A left intersection serving as an oxygen inlet is formed in the left side of the cooling module, and the oxygen input pipe is communicated with a humidification bottle of the oxygen generator and the left intersection; the right side of the cooling module is provided with a right intersection serving as an oxygen outlet, and the right intersection is communicated with an oxygen output pipe and an oxygen mask; a heat exchange unit is arranged in the cooling module, and the heat exchange unit is communicated with the oxygen inlet and the oxygen outlet. The temperature-control high-concentration normal-pressure oxygen generator has the beneficial effects that through systematic connection of the temperature-control high-concentration normal-pressure oxygen generator components, the oxygen temperature is accurately regulated and controlled when the temperature of a thermal therapy core rises, the problems of intracranial brain high temperature and severe brain hypoxia when the temperature of the thermal therapy core rises are solved, and the safety and comfort of the thermal therapy process are guaranteed.

The invention relates to the technical field of biological medicines and functional foods, and particularly discloses a giant salamander peptide composition for resisting cerebral hypoxia injury as well as a preparation method and application of the giant salamander peptide composition. The active ingredients of the giant salamander peptide composition are prepared by compounding giant salamander peptide, marine fish oligopeptide and chitosan according to a specific weight part ratio. The composition is prepared through a simple physical mixing method, all the components have a synergistic effect, and brain hypoxia injury is comprehensively resisted through a multi-channel and multi-target mechanism. Experimental results show that the ternary composition can remarkably improve dyskinesia caused by hypoxia, relieve apoptosis, inhibit inflammatory response, relieve oxidative stress and repair the integrity of a blood-brain barrier, and the effect of the ternary composition is far better than that of independent use of giant salamander peptide. The composition is high in safety and simple and convenient in process, and can be used for developing medicines or functional foods for prevention and adjuvant treatment of cerebral hypoxia injury.